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Author’s second book inspects humanity’s seemingly increase in aggression and the consequences of altering normal social interactions with technology…

DANVILLE, Va. (PRWEB) February 20, 2020

C.A.A. Savastano's new book "Human Time Bomb: The Violence Within Our Nature" confronts the long-term dangers of ignoring the modern descent into violent and irrational behavior that experts have long decried is aided by technology and modern social detachment. As new modern challenges face the nations of the world, a generation of humans has been developing under widely divergent social norms along with some modern ideas that do not comport with successful evolutionary strategies that have served humanity for millennia. As comfortable speech, political hyperbole, and censored environments become more prized, each seemingly reduces the ability of several people to use rational thinking and reasonable socialization.

The book considers the massive spikes in youth suicide and the diminishing capacity for human interaction as the modern world further replaces normal interactions with machine assisted socializing. While the benefits of technological development and social media are significant, the book offers the many consequences of increasing overuse that several cases attest ends in disaster. A pattern of worsening thoughts, mental illness, and violence seems to emerge as humans dive into a realm of interaction for which no substantial amount of long-term studies exist. Operating in this realm of the unknown has caused some to lash out ceaselessly unable to cope with the rapidly changing environment and exist by adapting its worst qualities. Human minds that require thousands of years to evolve are sometimes forced into destructive social patterns nature could not anticipate.

Using the scientific reports, educational studies, and supporting journalism the book offers additional historical context about significant issues such as parenting, the costs and benefits of gender roles, competing styles of economics, increasing hyperbolic politics, the role of technology in altering human behavior, and a host of debated modern cultural debates. It reveals some of our species most heinous tendencies are human problems and cannot be reasonably ascribed to any single culture if the greater scope of history is considered. Some of the most sinister periods of human aggression and the evolution of modern expressions of violence present the mental and emotional cost to all involved. The dangers of present day tribalism expose brutal social interactions and the habit of advocates to vilify those who disagree about nearly anything. Some of the most outspoken advocates of antisocial behavior are masked within political advocacy while their supporters join them in a spiral of worsening behavior online and in reality.

C.A.A. Savastano is an author, speaker, and Editor-in-Chief of the Neapolis Media Group whose historical research focuses on intelligence, government, international politics, and human behavior. He has studied thousands of legal documents, written over seventy research articles; consulted for multiple experts in his field, presented new research of public value, and makes regular appearances in the media. He is the author of "Two Princes And A King: A Concise Review of Three Political Assassinations", multiple academic groups have accepted his historical research findings, and Savastano has presented new evidence at public conferences and universities.

For all media inquiries please contact: Publisher Campania Partners LLC, Mike Swanson - contact [at] campaniapartners.com

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Author's second book inspects humanity's seemingly increase in aggression and the consequences of altering normal social interactions with technology...

COVID-19: Why you should call the coronavirus by its official name – ABC10.com KXTV

SACRAMENTO, Calif. The outbreak of a new coronavirus, first detected in Wuhan City, China, now has an official name.

In comments to the media on Tuesday, Feb. 11, World Health Organization (WHO) General Director Tedros Adhanom Ghebreyesus announced a name for coronavirus: COVID-19.

"Having a name matters to prevent the use of other names that can be inaccurate or stigmatizing," he said during his remarks. "It also gives us a standard format to use for any future coronavirus outbreaks."

COVID-19 stands for coronavirus disease 2019.

Coronaviruses are a large family of viruses that are common in many different species of animals, including camels, cattle, cats and bats, according to the Centers for Disease Control and Prevention (CDC). The center says it's rare for animal coronavirus to infect people and then spread between people such as with MERS-CoV, SARS-CoV, and now with this new virus named SARS-CoV-2, which causes COVID-19.

WHO, the World Organisation for Animal Health and the Food and Agriculture Organization of the United Nations developed the name based on best practices, according to health officials. The disease was previously referred to as 2019-nCoV, shorthand for novel (new) coronavirus found in 2019.

"We had to find a name that did not refer to a geographical location, an animal, an individual or group of people, and which is also pronounceable and related to the disease," the director general said.

Tracey Goldstein, professor in the UC Davis Department of Pathology, Immunology and Microbiology, said it's important to have an official name for the virus to curb misinformation.

"People may call a virus or disease by an incorrect name based on species or locations," Goldstein said. "If people think a virus comes from a particular location they may treat people from that area inappropriately."

As of Wednesday, Feb. 19, there are 15 confirmed cases of COVID-19 in the United States, according to the CDC. Health officials confirmed thefirst case of coronavirus in Napa Countyon Tuesday after a local hospital took in a patient from Travis Air Force Base after they were flown in from Japan.

Globally, there are 75,204 confirmed cases of COVID-19, according to WHO.

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Should an FDA warning affect your use of hand sanitizer? – WTOP

The FDA told the maker of Purell it could not claim that the product prevents viral illnesses, raising new questions about hand sanitizer use.

The Food and Drug Administration told the maker of Purell last month that it could not claim its product prevents the flu and other viral illnesses, raising new questions about hand sanitizer use.

In a letter to GOJO Industries, the FDA said it is currently not aware of any adequate and well-controlled studies demonstrating that killing or decreasing the number of bacteria or viruses on the skin by a certain magnitude produces a corresponding clinical reduction in infection or disease caused by such bacteria or virus.

Though the company may be limited in the claims it can make, hand sanitizers that have at least 60% alcohol content are still believed to be an important line of defense against getting sick, according to Dr. Julie Fischer, an associate research professor of microbiology and immunology at Georgetown University.

The correct use of hand sanitizer involves applying enough of it and rubbing your hands for 15 seconds, because the rubbing together actually helps destroy and remove those organisms as well, Fischer said.

Still, its preferred that you use soap and water and wash your hands correctly if you have time, she said, which means rubbing hands together for at least 20 seconds while washing.

Meanwhile, in an apparent vote of confidence for hand sanitizers, the FBI has ordered $40,000 of hand sanitizer and face masks in case the coronavirus becomes a pandemic in the United States, according to the acquisition document obtained by CNBC.

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Whats behind the tutu?: An anatomy of the costume as seen through Houston Ballets Sleeping Beauty – Houston Chronicle

With apologies to pointe shoes, nothing says classical ballet like a tutu.

For more than a century, little has changed with the basic structure of its two essential styles: the historically older romantic tutu, a long skirt whose loose layers flow with the body; and the short, stiff classical tutu the stuff of music-box figurines that forms a saucerlike, horizontal halo around a ballerinas hips, also distancing her arms from her torso.

Ben Stevensons formal production of The Sleeping Beauty, which returns Thursday to the Wortham Theater, features both types. But when most people think of tutus, what comes to mind is the classical version that began to appear in the 1870s.

Hard to believe now, but those first tutus created a bit of a scandal, exposing dancers thighs in ways that probably did not help the reputations of ballerinas who at the time were often seen as little more than talented call girls anyway.

Designers can tinker endlessly with the top decorations, but its whats underneath that gives a tutu its form. Viewing dozens of Sleeping Beauty tutus close up recently in Houston Ballets wardrobe studio, I couldnt decide if I was examining the downy, upended butts of a flock of exotic birds or rows of wispy daisies. They dangled sideways on hangers to consume less space on the rolling racks, with short, ruffled panties at their centers. (Ballet people still primly call the coverage part bloomers.)

Laura Lynch, Houston Ballets head of wardrobe, gives her staff a single, time-honored pattern for most classical tutus, guided by a handbook published in 1958: Joan Lawson and Peter Revitts Dressing for the Ballet, based on costumes created for the Royal Opera House many years before that.

A lot of what we do is restoration, preservation, rebuilding and refurbishment, unless its a new production, Lynch says.

She doesnt really need the book. She knows the requirements by heart. Tutus are designed in two parts. The fitted bodice is often boned inside to hold its form, with several rows of hook-and-eye closers on the back to accommodate dancers of various sizes. The Sleeping Beauty tutus have basques, elongated waistlines that dip with a V into the skirt/bloomer half.

The skirt portion is inspired by Elizabethan ruff collars, Lynch says.

The frilly, layered business consists of 9 yards of 54-inch netting. If you know sewing, thats almost enough fabric to upholster a small couch. The material is typically tulle, sometimes combined with stiffer tarlatan. The fabric is cut into 12 layers, in descending increments. The scissor-cut edges for the Sleeping Beauty tutus are dagged, or zig-zagged, at various lengths; but they can also be left straight or scalloped.

When: 7:30 p.m. Thursday-Friday, 1:30 and 7:30 p.m. Saturday; additional performances through March 8

Where: Wortham Theater Center, 501 Texas

Details: $25-$200; 713-227-2787, houstonballet.org

The layers descend from the basque, with bloomers sewn in. Each layer is secured with three threads of soft, cotton embroidery floss so that when it bounces, it bounces as a unit. A hoop in there somewhere helps keep the whole thing aloft.

Some classical tutus are more pancakelike, but Sleeping Beauty designer Desmond Heeley, who died in 2016, preferred a softer bell shape. He had tutus made at different lengths for different characters and dyed some of the undersides in gradated colors to create a gorgeous ombr effect.

A Tony Award-winning designer who trained as a milliner and prop maker, Heeley also designed the sets and costumes for Stevensons long-running productions of The Nutcracker and Copplia.

The Sleeping Beauty costumes are 30 years old but still dazzling, heavily embellished with glitter, shiny paint and plastic flowers.

Desmond loved using plastic, Lynch says. Any time I see plastic flowers, I pick them up because they dont make this stuff anymore. That is the hardest and my favorite thing to do: to keep a costume the way the designer designed it.

For this production, Heeley was honoring the 100th anniversary of The Sleeping Beauty, Lynch says. The show boasts 225 over-the-top costumes, including the tutus, with multiples of each design for different casts of dancers. Some of the tutus have been taken apart and put back together more times than Lynch can count.

We spend lots of love and money on them, she says, leading me through a maze of opulent confections on racks, including ballgowns for the royals, dresses for the peasants and the tearaway gown that conceals the evil fairy Carabosses tutu when she arrives at the ball.

Tutus worn by dancers who are lifted by partners require continuous attention. Lynchs staff has remade the Bluebird costume bodices this season, recycling their original dcor onto new fabric, and the stock of Princess Auroras bright-pink tutus is always being refreshed.

This is Auroras 16th-birthday-party Hello, Im lovely tutu, Lynch says, picking up the pieces of one that is currently dismantled. We bought new fabric and mixed it with old, cut the trimmings off and repurposed them. Next time we might add another tutu layer here, with a casing, and come out about 2 inches and add another hoop just to give it a little bit more life, before we have to gut it and re-net it again. We try to keep them living as long as we can.

She has completely rebuilt another Aurora tutu this season.

The name tutu likely evolved from the French slang tu-tu, meaning bottom.

Marie Taglioni was the first to perform in one the long, romantic style (and the first pointe shoes) during her fathers production of La Sylphide in 1832 at Paris Opera Ballet.

By the time Tchaikovskys Swan Lake debuted in the late 1870s, dancers could jump higher and were capable of fancier legwork. Their costumes began to creep up above the knees to better display their virtuosity.

Auroras pink tutu shows off the ballerinas one-legged balances through the famous Rose Adagio. Her friends and the various fairies wear slightly longer ones that are still considered classical; for a dance after Prince Florimund wakes up Aurora, Heeley put the ladies in romantic-style tutus that drift down around their calves.

Carabosse has the shows longest classical tutu, which Lynch calls a high-low.

Principal dancer Melody Mennite loves wearing it. Its really different, black and really lightweight, she says. Its a high-fashion moment. I feel like Im in an evening gown.

Mennite is not so fond of other tutus she has worn. When a gal is dancing a demanding role that already taxes her stamina, she says, a heavy tutu can impact your energy.

She has a love-hate relationship with the romantic but heavy tutu she wears as Clara during the Waltz of the Flowers in Stanton Welchs 2016 production of The Nutcracker. She has even given it a name, Rosy, she says, because it feels like Im toting another person across the stage when Im in it.

And she has not forgotten a La Bayadre tutu so stiff and wide she could knock a partner over with it, before the wardrobe staff reduced its diameter. It would be great if the ballet were a comedy, but its not, she says.

These days, choreographers hungry to update the art form experiment endlessly with tutu designs.

The wide, disclike biker-chic designs for Welchs revved-up Divergence are the extreme. Designed in 1994 by Vanessa Leyonhjelm for the Australian Ballet, they have leather-look bodices, with tutus that call to mind car air filters. In fact, they are made of plastic air-conditioning filter mesh that was spray-painted black at an auto-body shop, cut with a soldering iron and hand-pleated and edged with contrasting ribbon. From a side angle, they resemble ribbon candy.

Mennite chuckles, I imagine Stanton helped us out by putting in a moment when we toss them.

Holly Hynes tutu designs for Jorma Elos One/end/One, a 2001 Houston Ballet commission that the company will perform in March, aim for more of a bridge between the classical and the contemporary. They are topped with that same, stiff mesh but much smaller than the Divergence tutus, with just one arch-pleated hard layer over several layers of blue and black tulle.

Wearing tutus is just part of our everyday life, says principal dancer Yuriko Kajiya, who is scheduled to perform Feb. 27 as Princess Aurora.

Kajiya says she feels more comfortable onstage in a tutu than in a leotard, but with the exposure a tutu brings to her form, she concedes, you definitely feel like you need to pull yourself together.

No tutu has been more memorable for her than one she wore while guest-starring a few years ago for a small East Coast company whose costumes originally belonged to American Ballet Theater. Sewn inside an Aurora tutu was the name Natalia Makarova, evidence that it had been worn by the influential Russian prima who performed with ABT in the 1970s.

She was shorter than me, but I had to wear it, Kajiya says. I felt very special, wearing that costume. Like a little girl.

molly.glentzer@chron.com

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Whats behind the tutu?: An anatomy of the costume as seen through Houston Ballets Sleeping Beauty - Houston Chronicle

TV Ratings: Greys Anatomy and Station 19 Reach Four-Week Viewership High – Variety

February 21, 2020 10:49AM PT

Greys Anatomy and its Station 19 both drew their largest total audiences in four weeks on Thursday night.

Station 19 ticked up from a 0.9 rating among adults 18-49 last week to a 1.0 this time around, drawing 6.3 million total viewers, a 4% bump. One hour later, Greys came in at a 1.1 and 6 million, a 7.5% jump from last week. A Million Little Things rounded off the night even for the Disney-owned network at a 0.6 and 3.7 million viewers.

Young Sheldon scored the largest audience on the night with 9 million total viewers and a 1.0 rating, almost exactly the same numbers as last episode. Both The Unicorn and Mom ticked down from their multi-week high 0.8 rating. The two shows came in at a 0.7 this time around, drawing 6 million and 6.2 million viewers respectively. Carols Second Act and Tommy held steady, scoring a 0.6 and a 0.4.

The majority of the shows in NBCs Thursday night comedy lineup improved week-to-week. Superstore rose to a 0.7 and 2.7 million viewers, Brooklyn Nine-Nine jumped to a 0.6 and 1.9 million, and Indebted ticked up to a 0.4 and 1.6 million. Will & Grace matched Indebted with a 0.4 and just over 2 million pairs of eyeballs. Law & Order: SVU came in even at a 0.7 and 3.4 million viewers.

There wasnt much movement on the Fox front Thursday night, as Outmatched and Deputy posted the same 0.5 rating as last week, with the former drawing 2 million viewers and the latter 3.3 million. Last Man Standing rose fractionally to a 0.7 and 3.6 million viewers.

Finally on the CW, Riverdale spinoff was even week-to-week at a 0.1 rating and around 540,000 total viewers.

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TV Ratings: Greys Anatomy and Station 19 Reach Four-Week Viewership High - Variety

Anatomy of a grant: Ashley Kramer’s yearlong journey to finding her doctoral thesis – The South End

He asked her for a list of dream projects she would love to investigate. What followed was a year of challenges, stresses and the ultimate reward guided intellectual freedom toward scientific discovery.

Ashley Kramer, a student at the Wayne State University School of Medicine, is enrolled in the schools M.D.-Ph.D. program, an eight-year commitment broken down into three parts the first two years of medical school, four years of graduate school, then the final two years of medical school. Like all M.D./Ph.D. students at the medical school, Kramer had to complete research rotations with faculty she thought would make good dissertation advisors.

Because I have always loved stem cell biology and had experience working with zebrafish in the past, I decided to do an eight-week rotation in Dr. Thummels lab between my medical year one and medical year two, and made the decision that this was absolutely the perfect lab for me, she said.

Ryan Thummel, Ph.D., is an associate professor of Ophthalmology, Visual and Anatomical Sciences. His lab focuses on retinal development and regeneration in zebrafish, an attractive model to study neurodegenerative diseases because of its ability to regenerate neuronal tissues. Zebrafish fully regenerate their retinas in just a matter of weeks, an ability mammals lack.

Zebrafish and mammals both have a cell called Mller glia that supports retinal neurons. In zebrafish, however, these cells convert to stem cells and are responsible for retinal regeneration.

At the end of the rotation, Dr. Thummel floated the crazy idea of starting to work on this grant, a 70-plus page monster undertaking, during my M2 year, and I immediately jumped at the opportunity. I was excited at the idea of having a four-year research project completely planned out by the time I started my Ph.D. after M2 so I could hit the ground running after the dreaded STEP 1, Kramer said.

I came to him two days later with a nine-page document of project ideas. We sat down for three hours discussing projects and came up with a top-two list of cohesive projects for me to move forward with as a grant and thesis, she said. From there, it was a nearly yearlong process of writing, meeting, revising and repeating for each of the many sections of the grant.

The effort was worth it. Kramer secured a five-year, $294,102 grant from the National Eye Institute of the National Institutes of Health last year to study the molecular mechanisms of retinal regeneration in zebrafish, an organism that exhibits a remarkable capacity for regeneration.

"Ashley is a dedicated young scientist and worked very hard on this grant application," Dr. Thummel said.

The grant is one of the NIHs Ruth L. Kirschstein National Research Service awards, also known as an F30. The project, Elucidating the role of DNA methyltransferases in epigenetic regulation of retinal regeneration in the zebrafish, started last month. She is the principal investigator.

This was an incredibly challenging experience that allowed me to grow immensely as a scientist. Grant writing, planning effective and novel longitudinal scientific investigations, and time management will all be critical skills for me moving forward in my career as a physician scientist, she said. I cannot thank Dr. Thummel and my past advisors enough for all of their mentoring and support in the last ten years who have gotten me to where I am today, and I am looking forward to the rest of my training here at Wayne State and beyond.

Kramer earned her bachelors degree in Genetics, Cell Biology and Development from the University of Minnesota in 2014. Her love of research and stem cell biology started when she was an undergraduate research assistant there.

Nearly a decade later, she is studying how epigenetic marks are added to, and removed from, genes in zebrafish retinal stem cells during the process of retinal regeneration. The role of epigenetics in the body is akin to traffic signs on the road.

If roads had no traffic lights, stop signs or barricades, it would be complete chaos. The same is true for your cells. If you used every single gene encoded in your DNA 100% of the time, your cells would be chaos. Epigenetics is what is responsible for telling your skin cell to be a skin cell and your liver cell to be a liver cell, while they both have the exact same underlying DNA sequence, Kramer said. There are various different epigenetic marks that decorate the DNA without actually changing the sequence. These marks come in many forms and can act to either start, stop or change the amount that a particular gene is used, similar to how a green light, road block or stop sign direct traffic rules.

The process is critical for normal embryonic development and everyday cell processes.

If we can gain a deeper understanding of how species like the zebrafish are able to regenerate tissues when mammals cannot, despite having the same cell types, we may be able to start working to translate those mechanisms to mammals, she said. It is possible that certain regeneration pathways have been epigenetically silenced through evolution and we may be able to use modern advances in gene therapy techniques to unlock regenerative capacity in mammals.

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Anatomy of a grant: Ashley Kramer's yearlong journey to finding her doctoral thesis - The South End

Is Your Favorite Greys Anatomy Couple Really Over Forever? – Refinery29

Maggie is the one who spends Diagnosis trying to help her sister metabolize her pain over the Link situation. It would be easy for Greys to have Maggie, in this case the voice of reason, fully turn on Link because he made her sister sad. However, Maggie doesnt. During the meatiest part of the conversation when Maggie finally learns about the Owen part of the pregnancy equation Maggie explains why Links reaction to the messy paternity twist is sensible. She reminds Amelia that she and Owen have a complicated relationship, to put things mildly.

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Is Your Favorite Greys Anatomy Couple Really Over Forever? - Refinery29

Neurology Professor from Harvard Medical School Wins Barancik Prize for Innovation in MS Research for Work Resulting in New Tools and Treatments to…

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Newswise Dr. Francisco J. Quintana, PhD, Professor of Neurology at Ann Romney Center for Neurologic Diseases at Brigham and Womens Hospital, Harvard Medical School, is the winner of the National Multiple Sclerosis Societys Barancik Prize for Innovation in MS Research.

While the genetic origins of MS are becoming better understood, its less known how environmental factorssuch as pollutants, diet and intestinal bacteriamight contribute to MS and its progression. It is also not yet known how risk factors influence the immune system to attack the central nervous system. To address these questions, Dr. Quintana uses cutting-edge technologies to study the regulation of immune responses and inflammation in MS, molecular changes that trigger MS and environmental factors that influence disease activity.

Through a series of high-impact publications, Dr. Quintanas work has contributed new tools to further the work of the MS research community. His research has led to potential drugs for treating progressive MS, and has contributed to the development of a designer treatment called nanoparticles to control autoimmune activity. He recently developed anti-inflammatory synthetic engineered probiotics as a novel approach to MS therapy, and his team is currently licensing these probiotics to a new biotech for their clinical testing.

I recently completed what is so far the largest single-cell analysis of central nervous system cells in MS and EAE models Since this work generated one of the largest datasets currently available, it provides a unique resource for the study of the CNS in health and disease, Dr. Quintana said. Thus, we expect these datasets and novel methods to have a deep impact on MS research.

As for future research plans, Dr. Quintana will serve as the lead researcher on an international collaboration to develop a pipeline to identify the origins of progressive MS and new or repurposed drugs to treat it. His long-term goal is to identify mechanisms of disease pathogenesis and develop therapies for progressive MS.

Dr. Quintana will receive the Barancik Prize and deliver the Prize lecture at the ACTRIMS Forum. ACTRIMS Forum brings together more than 1,200 researchers and clinicians annually to share developments in the rapidly changing field of MS. The 2020 Forum will be held Feb. 27-29, 2020, in West Palm Beach, Florida. Themed Networks in MS, this CME-accredited meeting stands apart from many traditional medical meetings by offering a single track of scientific and clinical presentations in an interactive environment.More information about ACTRIMS Forum appears on the events website. Follow the event at #ACTRIMS.

Dr. Quintana earned a diploma in biology from the University of Buenos Aires and a Ph.D. in immunology from the Weizmann Institute of Science in Rehovot, Israel. He completed his postdoctoral training with a focus on neuroimmunology at the Weizmann Institute and at BWH. Among his many awards are Young Investigator Awards in Ireland and Italy, a Pathway to Independence Award from NIAID/NIH, and the National Multiple Sclerosis Societys 2014 Harry Weaver Research Scholar Award and 2017 Milestones in MS Research Award. The recipient of the 2016 Young Mentor Award from Harvard Medical School, he has trained more than 30 graduate students and postdoctoral fellows, and participates in several programs focused on training scientists from underrepresented minorities. He directs the Autoimmunity post-graduate course at Harvard Medical School, and the Seminars in Immunology post-graduate course at the University of Sao Paulo, Brazil.

The Barancik Prize seeks to recognize and encourage exceptional innovation and originality in scientific research relevant to multiple sclerosis, with emphasis on impact and potential of the research to lead to pathways for the treatment and cure for MS, and scientific accomplishments that merit recognition as a future leader in MS research. The international prize is made possible by the generosity of the Charles and Margery Barancik Foundation, and is administered through the National Multiple Sclerosis Society.

Read about the Barancik Prize and previous recipients

About ACTRIMS Founded in 1995, Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) is a community of leaders from the United States and Canada who are dedicated to the treatment and research in MS and other demyelinating diseases. ACTRIMS focuses on knowledge dissemination, education and collaboration among disciplines. ACTRIMS also provides a Forum for experienced and newer clinicians and researchers to exchange information, debate current issues and discuss advances related to basic research and clinical issues.

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Neurology Professor from Harvard Medical School Wins Barancik Prize for Innovation in MS Research for Work Resulting in New Tools and Treatments to...

Scientists turn organs transparent and capture 3D pictures of what’s inside – STAT

Scientists in Germany have turned human organs transparent and captured pictures of the complex cellular architecture inside, the latest advance in an effort to develop a new way to see inside our tissues.

The new work involved a three-pronged approach: stripping the pigment and fats from organs; capturing images of entire organs with a specially designed, larger microscope; and developing an algorithms to analyze those images and spit out maps labeled with specific cellular structures.

But outside experts said the technique described in a paper published this month in Cell will need more polishing before it might be ready for prime time as a new imaging method.

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The paper delivers impressive proof-of-concept demonstrations [but] it still seems like early days for broader use of the tool, said Katrin Amunts, a neuroscientist and director of the Institute for Neuroscience and Medicine at Forschungszentrum Juelich in Germany, who wasnt involved in the research.

Currently, scientists can study organs in living individuals with the help of imaging tools such as MRI and CT scans. They can also study slices of tissue from organs obtained postmortem and, with the help of new technologies, piece pictures of those slices together into 3D images of an organs structures.

But Ali Ertrk, director of the Institute of Tissue Engineering and Regenerative Medicine at Ludwig Maximilians University of Munich and senior author of the new study, is hopeful that his new approach could one day offer a new way to study organs in even closer detail.

With our technology, we can see every single cell in an entire human organ, said Ertrk.

Ertrk and his colleagues started their work by hunting for chemicals that could clean out the pigments and fats in organs, which block light. Ertrks lab and other groups had been able to clear the color from mouse organs. But the chemicals that worked in mice didnt work for human tissue, which grows stiffer as collagen and other molecules accumulate over time.

They eventually pinpointed a detergent dubbed CHAPS, which created tiny holes throughout organs. The scientists could then soak the organs in other solutions that rendered them transparent without damaging the tissue structure.

Its like converting milk into water. It becomes transparent, Ertrk said.

Ertrk and his colleagues partnered with the German-based biotech company Miltenyi Biotec to design a fluorescent microscope big enough to fit an organ-sized tissue sample under the lens. The microscope works on a sample as big as a human kidney, but doesnt work on larger organs, such as the brain, which Ertrk and his colleagues have also been able to turn transparent.

The pictures the microscope captured create another challenge: how to process and analyze the massive amount of data generated by imaging human tissue at the cellular level.

Ertrk and his team collaborated with researchers at Technical University of Munich to develop algorithms that could analyze the structure of the organs, including the blood vessels and individual cells. The algorithm was roughly as accurate at labeling cell types as a human identifying the structures manually.

Its a task that would take 100 years by hand, and now takes hours, he said.

Taken together, the approach to clearing and imaging intact organs is called SHANEL. The technology is still in the early stages. Etrk and his colleagues are working to develop a larger microscope that can image larger organs. They are also continuing to sharpen the artificial intelligence arm of SHANEL, developing new algorithms for each internal structure they want to identify, whether thats a neuron or a glial cell in the brain.

Amunts, the Forschungszentrum Juelich neuroscientist, said scientists need to carefully study how the process of chemically clearing an organ might affect specific types of tissue, particularly in different regions of the brain. The brains regions vary more widely than tissues in other organs, like the kidney. Theres also a need for more research into the accuracy of clearing approaches and how they stack up to standard organ imaging methods, like looking at 3D images of brain slices.

It remains to be demonstrated that the tissue-clearing approach presented in the paper reaches the same precision, reliability, and reproducibility that established [methods] have, she said.

Ertrk is hopeful that SHANEL can be used in the future to generate 3D maps of human organs that offer new insight into their function, structure, and the role they play in disease. That could be a helpful tool in studying complex organs, such as the brain, experts said.

For basic science studies on the brains structure, I think this can become a very valuable complementary method in the toolset of neuroscientists, Amunts said.

In the long run, Ertrk wants to use those maps to 3D print organs that accurately replicate their natural counterparts, down to the cellular level. Doing so, in theory, could mean creating lab-grown organs that function and potentially, could one day be used for transplants, though theres far more research to be done before that becomes a possibility, Ertrk said.

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Scientists turn organs transparent and capture 3D pictures of what's inside - STAT

Out of the Basement: Early Results Promising for Portable MRI – MedPage Today

LOS ANGELES -- An investigational low-power MRI scanner appeared safe and feasible for use at the bedside in a standard neuroscience ICU, researchers reported.

The 64-mT portable machine under development by Hyperfine Research required no shielding, no special power supply, no changes to the equipment used in the patient's room, and no precautions for ferrous metal, Bradley Cahn, BS, of Yale University School of Medicine in New Haven, Connecticut, and colleagues reported here at the International Stroke Conference.

Among 96 stroke patients scanned non-acutely (minimum 9 hours post-onset, mean 87 hours), there were no "significant" adverse events. Overall, 87% of participants completed the full exam: six participants experienced claustrophobia, and five didn't fit head and shoulders comfortably into the 30-cm opening.

Acquisition times were about 7.5 minutes for T2-weighted scans, 9.5 for FLAIR, 9.8 for diffusion-weighted imaging, and just shy of 29 minutes for a full exam.

Portable CT machines are already in clinical use for stroke, notably in mobile stroke units, noted Ralph Sacco, MD, chairman of neurology at the University of Miami and past president of the American Heart Association.

"If we could get MRI as quickly as CT scanning, some of us would prefer MRI over CT," he said in an interview.

MRI is a more sensitive indicator of brain injury and can pick up ischemia much earlier in the process when CT might still give a false negative, he noted.

The bulky machines needed to generate high-powered 3- and even 7-T MRI, risk posed by stray metal, as well as the wait and acquisition times have been hurdles, though, Sacco added.

"We have this incredibly safe technology, MRI, and we've put it in depths of the hospital's basement where you have to travel with the patient to get to it," said Cahn. "We've flipped that and brought the magnet into the patient's room."

There are plenty of other possible useful applications, though, said Cahn. Availability in the emergency room and ambulance "would be huge."

However, 28 minutes -- while fast for MRI -- might be just too long to consider overthrowing CT as the standard for urgent diagnosis in most circumstances, said ISC session moderator Justin Fraser, MD, of the University of Kentucky in Lexington. But it could be particularly useful for posterior circulation strokes, to determine futility of thrombectomy, he suggested.

The device still needs to be tested in the acute setting, though, Cahn noted.

"I think what they intended to prove, they proved that it was both feasible and safe to do in this limited, single-center population," commented Peter Panagos, MD, of Washington University School of Medicine in St. Louis, and American Heart Association/American Stroke Association Stroke Council Chair.

The study included both intubated and non-intubated adults in the neuroscience ICU who needed imaging as standard of care. Those with contraindications to 1.5-T MRI were excluded.

In theory, the device should be compatible with MR-compatible pacemakers and similar devices, but that hasn't been tested yet either, noted Cahn. "We just don't know how the low field strength interacts with devices like that. For example, some devices [that] are safe at 3 T may not be at 7 T and vice versa."

Nor were any scans done with contrast administration. Those studies will come, Cahn said, and the device continues to be iteratively improved.

Disclosures

The trial was supported by Hyperfine Research, which is developing the device, and by the American Heart Association.

Cahn disclosed receiving grants from Hyperfine Research.

Coauthors included some employees of Hyperfine Research.

Panagos and Fraser disclosed no relevant relationships with industry.

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Out of the Basement: Early Results Promising for Portable MRI - MedPage Today