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Medical Research and Innovation at Ohio State – Columbus Monthly

From a cancer vaccine to gene insertion for those with Parkinson's, local researchers are breaking through.

Research is big business at Ohio State University, with medical funding currently exceeding a quarter of a billion dollars, according to Peter Mohler, vice dean for research at OSUs College of Medicine. Ohio State gets grants from the National Institutes of Health and other sources such as other government agencies, nonprofit foundations and industry contracts.

Funding for OSUs College of Medicine, alone, now includes some $268.5 million. What follows are some of the latest breakthroughs.

An Anticancer Vaccine

A new anticancer vaccine, called B-Vaxx, is still in the early stages of being tested but initial studies are promising. The first-ever human trial at Ohio State led by researcher Pravin Kaumaya, a professor in the college of medicines department of obstetrics and gynecology, showed that patients with metastatic or recurrent solid tumors that overexpress the HER-2 protein had a stronger immune response than they did to current treatments.

This means that B-Vaxx may be more effective in killing tumor cells in many types of aggressive breast, gastroesophageal, endometrial, ovarian, colorectal and lung cancers. Although more research and clinical trials are needed, the bottom line on this first report is that scientists have concluded that the vaccine induced patient antibodies that showed potent antitumor activity.

Hope for Parkinsons

Dr. Krystof Bankiewicz, a researcher specializing in neurodegenerative disorders, and Dr. Russell Lonser, chair of OSUs department of neurological surgery, have been working with transformational gene therapy to develop cures for Parkinsons and other neurodegenerative diseases.

A one-step solution for Parkinsons could be the insertion of a non-pathogenic virus thats been modified to do only one thing: deliver the missing gene to a specific region of the brain.

The missing gene, if implemented, stops the progression of Parkinsons. Administering it, however, is a complex procedure. An MRI scanner is used to directly implant it in the brain.

Six clinical trials regarding the gene therapy and its effects on neurodegenerative diseasesincluding Parkinsons, Alzheimers, Huntingtons and moreare underway at Ohio State. In fact, the clinical trials for pediatric patients have been so successful that registration of the therapy has been fast-tracked with the U.S. Food and Drug Administration. There is hope that the drug will be approved this year for use in children.

Brain Stimulation

A small 2018 study at Ohio State implanted electrodes into the frontal cortex of Alzheimers patients and programmed a pacemaker to deliver deep brain stimulation. DBS has already proven to be helpful for patients with Parkinsons, epilepsy and obsessive-compulsive disorder. And, it is currently being studied for addiction, chronic pain, multiple sclerosis, traumatic brain injury and more.

Two of three people showed statistical improvement, says Dr. Douglas Scharre, professor of neurology and clinical psychology at OSUs Center for Cognitive and Memory Disorders and its Center for Neuromodulation. One patient was able to plan an outing and handle money, make plans for an event and cook a simple meal. These may seem like minor improvements, but if the patient cant do it, the caregiver has to.

Atrial Fib: The Watchman

Among the 3,000 clinical trials at various stages at Ohio State in recent years has been apilot studylead by Dr. Ahmet Kilic, former OSU associate professor of cardiac surgery, on the efficacy of the Watchman, a tiny parachute-like device which is implanted into the heart to regulate the heartbeat of those who suffer from atrial fibrillation. (Kilic is now director of heart transplantation and mechanical circulatory support at Johns Hopkins Medicine.)

Along with reducing stroke risk, the Watchman allows for remote monitoring of heart function. Watchman patients also forgo the risk of excessive bleeding caused by long-term use of warfarin, such as Coumadin and other blood thinners. The implantnow in more than 100,000 peoplecan eliminate regular blood tests and food-and-drink restrictions that come with warfarin.

Expecting a Daughter?

Researchers at the Wexner Medical Center have found thatthat immune cell samples of women carrying girls produced more proteins called pro-inflammatory cytokines than those carrying boys, resulting in exacerbation of conditions such as asthma, and contributing to fatigue and achiness.

Too many of these cytokinescan really be unhelpful for our bodies functioning, explains Amanda Mitchell, lead author of the study while she was a postdoctoral researcher in the universitys Institute for Behavioral Medicine Research. Women carrying girls exhibited greater inflammatory responses when faced with some sort of immune challenge compared to women carrying boys.

Exercising and doing relaxing activities, such as meditation, are recommended. Also, eating healthy foods, including leafy greens, will better support healthy immune responses. Mitchell is now an assistant professor at the University of Louisvilles department of counseling and human development.

More Sleep EqualsHappier Marriages

According to the Centers for Disease Control and Prevention, 35 percent of Americans get less than seven hours of sleep per night, resulting in increased risk of stress-related inflammation and ensuing chronic illnesses such as cardiovascular disease, diabetes, arthritis and others.

In arecent studyat Ohio States Institute for Behavioral Medicine, married couples were asked to supply blood samples and information regarding hours they slept the previous two nights. They were then asked to resolve a conflict, with blood samples taken after the discussion. Although people who had slept less initially had no more inflammation than usual, there was a greater inflammatory response after the conflict. Furthermore, if both partners got less than seven hours of sleep the previous two nights, they were more likely to become hostile.

Couples using unhealthy resolution tactics had an even greater inflammatory response. In a marriage, sleep patterns often track together, explains Janice Kiecolt-Glaser, the senior author of the study and director of OSUs Institute for Behavioral Medicine Research. If one person is restless, or has chronic problems, that can impact the others sleep. If these problems persist over time, you can get this nasty reverberation within the couple.

Less Stress, Better Health

Dining on a Greek salad may be great, but if youre stressed, it may be no better for you than fish and chips, according to an Ohio State study published inMolecular Psychiatry. In the study, 58 women were given two different types of meals, one high in saturated fat, which has been linked to cardiovascular disease, and another with more heart-healthy, plant-based oil. The meals were similar in terms of calories and grams of fat. While inflammatory responses were predictably lower if the women were not stressed after the healthier meal, if a woman was stressed, it looked like she was eating the saturated fat meal in terms of her [inflammatory] responses, study author Kiecolt-Glaser told National Public Radio.

Even though the stressors were for everyday issues, such as dealing with a sick parent, the stress seemed to boost inflammation, increasing chances for disease and slowing the healing process. Still, more research needs to be done and there are plenty of ways to combat stress, includingdeep-breathing.

Immune Cells and Sex

An Ohio State study done on rats and reported in theJournal of Neurosciencefound that immune mast cells,usually ignored by neuroscientists, appear to play an important role in determining the gender of an animals sexual behavior.

When researchers, led by Kathryn Lenz, assistant professor of behavioral neuroscience, silenced the mast cells in male fetal rats, they found that the adult males were far less interested in having sex with females. In fact, they acted almost like females, according the study.

Newborn female rats whose mast cells were activated with a stimulating chemical did the opposite, showing more traditionally males behaviors. Lenz theorizes that if human development mirrors what was seen in this study, even relatively minor influencessuch as an allergic reaction, injury or inflammation during pregnancycould possibly steer sexual behavior and development.

On the Move: Its All Good

According to Bernadette Melnyk, chief wellness officer and dean of OSUs College of Nursing, researchers at the American College of Sports Medicine have confirmed that physical activity completed in any duration is associated with health benefits and count towards your recommended 150 minutes of weekly activity.

Traditionally, physical activity recommendations have focused on accumulating moderate-to-vigorous physical activity either in a continuous manner, such as going for a 30-minute run, or in short bouts performed throughout the day, according to theACSM. However, in 2018, thanks to the advent of digital and other activity trackers, the ACSM also recognized that most daily activity is sporadic and is typically performed in bouts that are less than 10 minutes in duration. Any such activity is now associated with favorable health-related outcomes.

Take time each day to get moving, even if only for five minutes, adds Melnyk.

Reprinted fromColumbus Monthly Health 2020.

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Medical Research and Innovation at Ohio State - Columbus Monthly

highlandcountypress.com – The Highland County Press

Dr. Karissa L. NiehoffExecutive DirectorNational Federation of State High School Associationshttps://www.ohsaa.org/

While the behavior of parents and other fans at high school games is still a work in progress, there is some good news on the officiating front.

Last fall, we reported on a growing shortage of officials nationwide even reaching a crisis stage in some areas as games were being canceled. Through a nationwide recruitment effort, progress is being made in attracting more people to the high school officiating avocation.

Thanks to the NFHS #BecomeAnOfficial campaign that was launched in the spring of 2017, more than 4,000 men and women across the country have registered and become certified officials. Many of these individuals are former high school athletes who want to remain involved in sports, earn some extra income and stay in shape, including first responders such as police officers, firefighters and EMTs.

Individuals interested in becoming an official can sign up through the http://www.HighSchoolOfficials.com website, and most state associations respond within 24 hours to continue the registration process.

On the flip side, however, is the fear that any gains in new officials coming in the front door are being offset by other officials heading out the back door because of the continued boorish behavior on the part of parents and other fans.

Rickey Neaves, associate director of the Mississippi High School Activities Association, is struggling to cover all basketball games in his state in his role as officials coordinator.

Fans and coaches alike feel freer to downgrade officials, and holler and scream at them, as opposed to the way it was 10 years ago, Neaves said. You can see where it is getting worse and worse with parents and coaches blaming officials or staying on an official to the point where theyre just not going to take it, so they just get out.

Unfortunately, we continue to hear reports like this from across the country. A recent survey conducted by Officially Human: Behind the Stripes that was completed by about 19,000 respondents in 14 states indicated that the problem persists, with fans who do not know the rules being the main culprit.

If efforts by the NFHS at the national level and others at state and local levels to attract more people to officiating are to be successful, unsportsmanlike behavior on the part of parents and other fans must cease or we will lose some of these new officials within two years.

While we recognize the task of improving the culture at high school events is challenging and is one more item on the busy plates of school administrators, it is essential if we are to retain officials.

Brenda Hilton, founder of Officially Human: Beyond the Stripes, said The time is now for all of us to realize that officials are human and their existence and hard work at sporting events allows all of us to enjoy the games that we love. We must start to humanize officials now before the whistles fall silent.

Recognition and thanks should also be a part of the game plan. We must regularly share our appreciation for the men and women who officiate high school sports.

Dana Pappas, commissioner of officials for the New Mexico Officials Association, shared the following with officials in her state during a special appreciation week:

Never think that what you do as an official doesnt matter because it does. Never let one contest where the fans are exceedingly brutal and the scrutiny is overly intense derail your love for what you do. Never think that you are not making a difference because you most definitely are. You are educators, role models and guardians of the integrity of the sport you officiate. You officiate because you care about kids, you care about your chosen sport and you care about your community.

Instead of viewing these officiating issues as a crisis, lets see them as an opportunity to impact lives through education-based athletics.

Dr. Karissa L. Niehoff is in her second year as executive director of the National Federation of State High School Associations (NFHS) in Indianapolis, Ind.

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highlandcountypress.com - The Highland County Press

How To Turn Down The Boil On Group Conflict – Forbes India

Image: Shutterstock Even as polarized political discussion appears to have frozen the possibility of compromise, new research suggests that divided sides can come together on many issues to make decisions.

Our research finds that inaccurate beliefs really drive behavior and contribute to intergroup conflict, says Jeffrey Lees, a doctoral candidate in Organizational Behavior and Psychology at Harvard Business School.

In actuality, most people have a wildly inflated sense of just how negative the other side feels, according to a new paper that Lees co-wrote with Harvard University Associate Professor of Psychology Mina Cikara. If you forecast that no matter what you propose, the other side will hate it, then you are going to say compromise is a waste of time, Lees says.

The paper, Inaccurate Group Meta-Perceptions Drive Negative Out-Group Attributions in Competitive Contexts, was published in November 2019 in the journal Nature Human Behavior.

We want to compromiseIn a series of experiments, Lees and Cikara found people are much more willing to compromise, but resist trying because they think those on the other sideand even those within their own groupwill resist going along. But they also unearthed good news on how mistrust can be overcome on many issues.

Lees first started considering these dynamics in a business context. I was thinking about how people inside organizations predict how people outside of the organization perceive it, and how they might get that judgment wrong, Lees says. It didnt take me long to realize how that sort of judgment applies in other contexts.

He teamed up with Cikara, whose lab has looked at how peoples perceptions of others changed based on whether they think of them as individuals or groups. How we attribute motives to other people becomes distorted when we stop thinking of them as individuals and instead move to a framework of us versus them, Cikara says.

In a political context, that can quickly lead to conflict.

People not only have stereotypes of what other people are like, they also have stereotypes of what other people believe, Cikara says. They hate us for our freedom, or they think were liberal snowflakes, or theyre doing that to be obstructive, or they want to ruin our American way of life. But when you actually talk to people about their opinions, almost nobody actually talks like that.

Lees' and Cikaras experiments found most people are much less negative than the stereotypes we harbor about the other group. For each experiment, the researchers presented real-world scenarios that advantaged one side or the other, and then asked participants to predict how negatively the other side would react.

For example, one scenario presented to participants who identified as Democrat, explained that Democrats in a state legislature were considering a change to committees that draw voting lines. While currently, committee members were appointed by the governor, a Republican, the new proposal would allow equal representation by both parties.

They then asked participants to predict on a 100-point scale how much Republicans would dislike or oppose the measure or consider it politically unacceptable. Responses averaged in the 80s, with the largest clump at 100.

As negative as possibleThe forecasts were pretty much as negative as possible, Lees says. In reality, however, the real responses were closer to 50showing that participants overrated how badly the other side would feel.

Lees and Cikara found similar results for other scenarios, involving changes to selection of judges, campaign financing, and renaming of a state highway. (The researchers purposefully stayed away from hot button issues such as gun control and abortion, which might spur too much passion.)

The results were consistent for both Democrats and Republicans, or even if they just presented an anonymous Party A and Party B.

They are totally insensitive to the scope or impact of the issue, Cikara says. They just think the other side is going to be upset about anything.

Even more interesting, people made the same forecasts about others in their own group, believing their fellow Democrats or fellow Republicans were angrier about a measure, even when they themselves were only mildly opposed.

Having such polarized views of both political parties naturally leads to less willingness to negotiate and compromise, Lees says.

If you are a legislator, you are thinking no one across the aisle or in my own tribe will support compromise, but thats in fact wrong. Both sides might be okay with compromise, but no ones willing to propose it because of inaccurate forecasts.

Overcoming bias to reach cooperationThe news from their experiments wasnt all bad. When the researchers flipped the script to create scenarios that were cooperative, study participants were much more accurate in their predictions. For example, in the voting districts scenario, the researchers told participants that it was Democrats who were proposing the change to make the commission fairer, even though a Democrat was currently in the governors office and stood to lose advantage through the change.

In that case, Democrats and Republicans alike accurately predicted how both sides would feel.

Suddenly, peoples forecasts become accurate, which is quite an optimistic finding for cooperation, Lees says. If you can actually engender cooperation, people are much more likely to have accurate perceptions that might drive reconciliatory behavior.

In a final experiment, Lees and Cikara showed that people could change their perceptions when confronted with new information. After making their own predictions about the negativity of the other side, participants were shown their true level of oppositionon average, much lower than theyd assumed. Afterwards, people decreased the degree to which they thought the other side was engaging in purposeful obstructionism.

Theres a lot written about how people are totally insensitive to the truth when told that their beliefs are wrong, Lees says. This suggests thats not the case. People are willing to update their beliefs when they are simply told they are inaccurate.

Better business outcomesThis finding, which indicates the potential for creating cooperation, carries implications for business as well.

In the context of teams or negotiations, adopting a competitive mindset can lead to undue pessimism about how others feel, Lees says. These inaccurate beliefs can lead to missed business opportunities. But if those contexts are reframed as cooperative, accurately forecasting how someone across the negotiation table might respond to a particular proposal becomes easier.

Thats good news in a society that often seems to be grappling with intractable partisanship on every issue. While some issues may still present a gulf too wide to bridge, the study shows that there is at least some room for compromise and mutual understanding between the parties, if they can just start talking to each other.

When youre not talking about hot-button issues, you shouldnt be afraid to broach the topic with people who have a different position than you, Cikara says, because it turns out you most likely have an inaccurate perception about what they thinkand they have the same of you. All it takes is one person to break the cycle.

Michael Blanding is a writer based in the Boston area.

[This article was provided with permission from Harvard Business School Working Knowledge.]

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How To Turn Down The Boil On Group Conflict - Forbes India

Difference, Division, Desi Breeds : Intuitive Economics and the Outcome of an Operation – Economic and Political Weekly

Suppose, in a business you invest 1,000 and get 1,500 as return. You have 500 as net profit. Suppose you expand on the business by additionally investing 1,000. Now you get a net profit of 800 instead of 500.Would you consider the decision of this additional investment as a wise decision? We raised this question in a meeting of a mixed group, consisting mainly of social workers working with farmers, fisherfolk, pastoral, and tribal communities. We were discussing the economics of livelihood for people dependent on nature. Some of them said, Yes. We will invest 1,000 more because by doing so, our net profit goes up. Some of them said, No. This is not wise! Because, even if net profit goes up, it is not in proportion to the additional investment. The ratio actually decreases with the additional investment.

Which of the answers is correct? Is it really wise to make the additional investment or not? Both the groups certainly used logic which was right in their context. Both the groups were doing a careful costbenefit analysis. But, one group was using net profit, defined as returns minus the cost. The other was using a ratio, defined as returns divided by the cost. Interestingly, even within the latter group, individuals working with farmers appeared to think in a different way than individuals working with tribal communities. For this article, we will use the words cost and benefit to describe the actualities of a deal, and the words investment and returns to refer to the perceptions and strategies of an investor.

Although the dilemma of using difference or division, or rather when one should use difference and division, could seemingly be solved by employing common sense, we believe it is a fundamental question that requires serious thought. Many people may not even think that it is an important question, since business wisdom lies in reducing costs and increasing returns. Theoretically, if business wisdom is applied in real-life situations, both difference as well as ratio willincrease. But, this does not always work. The above example, although very simple, demonstrates that optimising difference and optimising ratio can lead us to diametrically opposite decisions. The question is not only important in economics, but also in biology. Evolutionary biologists frequently worry about budgets, where energy, time, health, longevity, or reproductive success is the currency. Only the ones with a profitable budget will survive. As a result, an intuitive sense of optimising has evolved in animals. It is unlikely that humans are an exception to the evolved intuitive optimisation mechanisms. But, humans also have conscious thinking and theorisation, so we should seek a logical explanation for our decisions in our conscious beliefs and theories. So, we wanted a logical answer to the question of when to divide and when to subtract.

We then started scanning economics textbooks and asking economist friends about when to take the ratio and when to take the difference in the costbenefit analysis. The economists we consulted ranged from teachers of first-year economics in colleges to senior economists working as consultants in multilateral organisations. Surprisingly, we did not get any definitive answer. The responses included Use ratio; Use difference; We always use ratios, but I dont know why; Use either, what difference does it make? I dont know; and Frankly speaking, I never thought of this question. The theory of probability in mathematics begins with two simple rules that tell us when to add probabilities and when to multiply. We thought there would be such simple rules that instruct when to use difference and ratio. However, we learnt that such rules do not exist, or even if they do, most economists, at least in our sample, do not seem to know them.

Use of Ratio and Difference

So, how does it matter whether we take difference or ratio? As we discussed further in that group, some inquisitive individuals asked. Are we limited to only one business? What if we start a second unit of the same business and invest another 1,000 in it, instead of going from 1,000 to 2,000 in the same unit? With two independent units of the same business, we will earn 3,000 with an investment of 2,000. This is better than earning 2,800 from 2,000. This turned out to be the key question, and it gives a simple answer to the fundamental question as well. If you have multiple investment opportunities, then go by the ratio, and if you have a single opportunity or your possible investment opportunities are almost saturated, then you should go by the difference. The same can be demonstrated by a more rigorous mathematical proof given in Box 1.

A simple generalisation is that whenever a law of diminishing returns applies and there is an overhead cost in the endeavour, the difference optimum is typically much to the right of the ratio optimum (Box 1 and Figure 1). Thus, to maximise net benefit, it is necessary to invest much more in terms of money or efforts. Whereas, in maximising the benefit to cost ratio, it is a better strategy to have a smaller investment per unit, but to increase the number of units. In simple words, when there is one investment opportunity, it is desirable to extract the maximum output from the unit, even at a higher cost. Whereas, if many replicates of the unit are possible, it is desirable to invest less per unit, but increase the number of units. How much to invest in a unit depends on the overhead costs too. With greater overhead costs of a unit, one needs to invest much more in the unit. The higher the overhead investment, the lower the difference between ratio optimum and difference optimum. The investment still remains lower in ratio optimisation than in difference optimisation. So, the choice of model (whether to use difference model or ratio model) and the optimum investment per unit depends upon how many investment opportunities you have and the overhead cost.

In the case of Indian agriculture, a farmer most commonly has only one investment opportunity: their own land. Therefore, it is natural to use a difference model and extract maximum output, even at a higher cost. On the other hand, in the case of livestock in the Indian context, more investment opportunities (number of animals) are available, so the natural tendency should be to invest little per animal, but let the number of animals increase on their own.

Domesticated herbivores in India typically grazed on common pasture lands (Roy 1997). Therefore, keepers have little overhead as well as running costs. In a ratio model, when the denominator is near zero, the ratio is always high and, therefore, there is no need to worry so much about the productivity of an individual animal. In the context of a typical Western dairy farming model, where there are private ranches, a ranch becomes the unit, and since the owner has a single unit, there would be an attempt to increase the net productivity of the unit even at a higher investment. In this model, on the one hand, investment on owning the huge piece of ranch increases the overheads, making high productivity necessary. On the other hand, long-term assured ownership is a good motivation for worrying about sustainability. Therefore, there is no option but to increase the investment per animal, at the same time, keeping the number of animals limited.

In that context, cattle are more like a crop and land is a limiting factor. This sets the ground for a difference model to work in which the investment as well as productivity goes up. Thus, the economics of modern Western dairy farming and traditional cattle keeping is fundamentally different, and therefore, the breeds and characteristics of animals supporting the two economic models are also fundamentally different. In a ratio model that is typical of traditional Indian animal keeping, people will tend to select animals requiring near zero inputs without worrying much about their productivity. In the modern Western private ranching system, there would be a selection for high-productivity animals even if they require greater inputs. The difference in productivity in different varieties of animals originates in the selection operating on these animals. Animals bred for generations in the difference model become more productive, and those under the ratio model become more hardy and resilient, but less productive.

Innate and Intuitive Economics

Evolutionary ecologists have shown that even the so-called dumb or unintelligent animals with tiny brains make very careful costbenefit judgments. For example, a parasitoid wasp typically lays eggs on the caterpillar of a host insect. The number of eggs to be laid on a given caterpillar is a complex investment decision. The optimum egg investment per caterpillar unit depends upon a number of factors, including the expected remaining lifespan of the female, the residual egg-laying capacity, the probability of finding more host caterpillars, whether a caterpillar found already has eggs laid by a competing female, and so on. Mathematical ecologists have shown that wasp females are able to take a complex economic decision (Heimpel et al 1996: 241020).

Considering the astonishing innate mathematical ability of a wasp, it should not be surprising that even illiterate humans do take wise economic decisions even when they have not studied economics formally. Humans appear to make complex costbenefit analysis while making several decisions where the currency need not always be money. Time, labour, energy, sex, reproductive success, survival, or social status work as currencies in human intuitive economic calculations (McNamara and Houston 1986: 35878), but it is beyond doubt that using costbenefit optimisation is an innate tendency of animals (Parker and Smith 1990: 2733; Smith and Winterhalder 1992: 2560) and that legacy continues in humans. Formal education is not a primary requirement for making such complex calculations. While doing formal economics, some of the currencies can be put in numbers as equivalents of money, whereas for other currencies, it is difficult to set up an equivalence with money. Herein lies the difference between intuitive economics and formal economics. Nevertheless, the fundamental principles of costbenefit analysis, including the above stated rule about ratio versus difference, need not be different.

If asked directly, farmers do not know what a difference model is and what a ratio model is, but they appear to use the right model in the right context. In another study published earlier (Bayani et al 2016), we tested the differential predictions of the difference versus ratio models on a set of farmers (Watve et al 2016: 86167). The results showed very clearly that farmers unanimously used the difference model. Thus, the farmers appeared to have an intuitive knowledge of some principles of economics, which our educated economists have not yet clearly figured out.

Hybrid Crops vs Crossbred Cows

The green revolution entered India in the late 1960s. It was brought in by government efforts, with the help of visionary scientists. The government wholeheartedly promoted the use of hybrid seeds, chemical pesticides, and fertilisers, bringing about changes in traditional farming practices. The new agricultural practices needed more investment not only in purchasing hybrid seeds, but also for chemical fertilisers, pesticides, and irrigation. Hybrid or high-yielding varieties of seeds certainly required more care, since they were more susceptible to climatic variation as well as diseases and pests. Within a decade, almost the entire country changed agricultural practices. Individual farmers invested more in order to get more returns, although the benefit to cost ratio might have actually declined. It should also be noted that although there were many incentives and promotional schemes launched by the government, nothing was made mandatory. The farmers largely accepted the green revolution in a short span of time.

More recent is the specific case of Bt cotton. India is the worlds largest cotton producing country (Statista 2019). Bt cotton was introduced in 2002, and it took a few years to be known. Soon, Bt cotton percentage in terms of production area boomed up from 6% in 200405 to 81% in 200910. In less than eight years, 93% cotton farmers started using Bt cotton (ISAAA 2014). The change was so rapid that non-Bt cotton seeds were practically out of the market, and many indigenous varieties were threatened to extinction (Kumarnath 2016). More generally, hybrid or high-yielding varieties have replaced indigenous varieties, and a special drive is needed to conserve indigenous varieties.

In contrast, if we see the case of livestock, Operation Flood, launched in 1972, was a project of Indias National Dairy Development Board (NDDB), which was the worlds biggest dairy development programme. High milch foreign breeds were introduced in the cattle population. Programmes like artificial insemination (AI) were launched, with substantial thrust from government and non-governmental agencies. Concerned agencies worked with targets and tried to reach out to every doorstep to inseminate local cows with high-quality semen (NDDB 2015). Furthermore, there were moves to improve feed, fodder and veterinary services. But, the efforts precede Operation Flood since even before Operation Flood, there were active efforts to eradicate and replace indigenous cattle. For example, in Kerala, castration of local bulls was made mandatory under the Kerala Livestock Improvement Act of 1961. Under this act, any bull of an indigenous breed reaching sexual maturity had to be castrated and a task force set up to implement the castration operations at a mass scale. Nothing comparable to this was ever done for Bt cotton or any high-yielding crop variety. Even doorstep-level facilitation and persuasion was never needed for the green revolution. In spite of all such efforts, the trend in the growth of exotic/crossbred cattle remained poor, in contrast with the trends in high-yielding crop varieties (Figure 2).

Although there has been a steady decline in indigenous cattle percentage and a steady increase in exotic/hybrid cattle, the percentage share of exotic/crossbreed cattle has increased only by 14% in two decades (from 1992 to 2012). In comparison with the 93% spread of Bt cotton in eight years, this increase is meagre. Particularly notable is the vast majority of the so-called non-descript cattle (DAHD 2012). There have been excellent indigenous cattle breeds, such as gir, that are high-yielding, but even they were never abundant across the country. Majority of the population was happy with the low-yielding one, but self-sustaining hardy cattle that needed little care and survived droughts, diseases, and parasites (Mazoomdaar 2013). These animals performance was poor if seen through the difference model, but excellent by the ratio model because theinvestment needed was negligible.

Thus, there is a stark contrast between peoples response to high-yielding crop varieties and high-yielding animal breeds. They seem to have accepted the former in a short time, but have resisted the latter even after the option has existed for a long time. We feel that the difference lies in the economic model of optimisation used. With the difference model predominating agricultural economics, they are ready to invest more money and efforts and go for higher yields. But, with animals, they are happier with small yields coming out of near zero investment because they are using a ratio model. This choice of the model is completely innate and intuitive. Nobody did any calculations consciously. Such calculations must be as natural and built-in as the wasp optimising her egg investment. Now, it is high time that formal economics recognises the innate economic models of people.

Ratio Model in Agriculture

The ratio model can be appropriate for agriculture under a set of conditions. In slash-and-burn agriculture, where new land can be brought under cultivation, that is, new investment opportunities can be created, a ratio model will work better. Also, in a society that is free to expand the agricultural land, a ratio model is appropriate. We see this difference in the history of modern agriculture too. In the 1960s, the green revolution took quick and firm roots in India, but it did not succeed in much of Africa, although its promotion was attempted (Pingali 2012: 12,305). For the 1960s population-to-land ratio in much of Africa, people could rely on the ratio model and were not interested in difference optimisation. As the population grew, and there was a clear demarcation of agricultural lands and land saturation, the difference model started gradually taking over, and the response to the green revolution improved.

Today, we see substantial and sincere efforts to promote zero-budget agriculture, which is ecologically sound (Palekar 2007). We raise no doubts about the ecological and sustainability-related merits of zero-budget agriculture. But, the response from the farmer community to this model so far is extremely limited. Out of the 140 million hectares (ha) of agricultural land in India (Directorate of Economics and Statistics 2014: 305), farmers have committed to organic farming in only 0.51 million ha (PoliticalTruth 2016). The reason is likely to be that the promoters are trying to promote ratio optimisation (Misra 2007), whereas the farmers community has a difference model in their intuitive calculation. It would be necessary for the promotion of organic farming to rework its economics and see how it performs in a difference model. If Misras (2007) claim is correct, both the ratio and difference models could be more favourable in spiritual agriculture. But, unless it is propagated by projecting its economic superiority by the difference model, farmers are unlikely to adopt it on a large scale.

When Two Optima Contradict

The contrasting example comes from the rapidly rising dairy industry. When a dairy company or cooperative is established, it has invested substantial amounts into overhead costs like land, establishment cost, machinery, storage, and supply chains. Although the dairy industry might still be using the ratio model, a rise in overheads shifts the optimum to the right. The dairy unit has certain other limitations. It can take raw material from several cattle or buffalo owners. But, since milk is highly perishable, there is a limit to the area from which it can transport raw milk. Within this area, they need to maximise the incoming flow. Therefore, the industry is interested in a higher investment and higher returns model. This goes in a subtle conflict with the animal owners. The optimum for the industry is far to the right than the optimum for animal keepers (Figure 3, p 31). As a result, the industry would have to take special efforts to motivate people to increase their investment per animal and improve the returns per animal. For this, they need to give incentives, attractive offers, free veterinary services, animal insurance, assured market or some other means to motivate them. Only with such efforts, the high-yielding varieties can be sustainable by peoples intuitive economics.

As a result, in the milk catchment area of large dairy units, high-yielding breeds are expected to be better accepted by people. In the absence of incentives and active promotion by organised dairy agencies, people are unlikely to accept and maintain these varieties on a mass scale and over a long time. This prediction of the hypothesis matches with the statistical trend. The spread of cross-bred varieties closely follow the rise in the dairy industry (Figure 4).

Dairy Industry and Breed Selection

The organised sector of the Indian dairy industry started growing post-independence, and in the early 1960s, the share of the organised sector in total milk procurement was only 3.7%. By the mid-1990s, it reached 12% (Sharma et al 2002). By 2008, the share of organised milk production was 23.39%, and by 2015, it was 26.26%. The pattern of this rise is closely followed by the pattern of the number of cross-bred cattle reflecting acceptance of cross-breed cattle by people. Although the jersey cow was introduced in India long ago in 1856 (Chako 1994), systematic breeding programmes began only in the 1960s. Thereon, it followed the growth curve of the organised dairy sector very faithfully. Even geographically, the statewise success of artificial insemination programme shows a good positive correlation (r = 0.64, p = 0.018) with the number of organised sector units and the total capacity (Figure 5). The correlation remains significant even after correcting for the area of the state. Thus, much of the spread of high-yielding cattle is catering to the economic interest of the organised dairy industry rather than the economic interest of individual cattle keepers.

Our emphasis on the use of ratio versus difference models of intuitive economics does not mean that other factors, such as government policies, market infrastructure, advertising andsocio-politicalcultural acceptance do not play any role in the growth and acceptance of high-yielding varieties. But, it gives the right platform on which the effects of every factors can be rightly mapped. If planning is based on the appropriate economic model, the implementation is more likely to be effective.

Conclusions

For any microeconomic model, it is necessary to have clarity about whether one should use a ratio model or a difference model. People appear to use the two models discriminately and appropriately. Formal economics needs to realise this, which would help the planning of large-scale operations in the right direction and in the most effective way.

This article is neither to support genetically modified (GM) crops, nor to oppose better animal husbandry practices. It demonstrates how the underlying innateintuitive economic model used by ordinary people dominates the outcome. For promoting any new technology or practice on a nationwide scale, it is necessary to understand peoples economics without which huge efforts can turn unproductive. The whole motive of this analysis is to understand how microeconomics at the farmers level affect trends in a bigger picture. It is surprising that such an analysis has not been the centre of thinking in this field. Huge amounts of efforts have gone into developing better breeds, sperm banks, artificial insemination techniques, and the like. A number of excuses are given to explain the relative failure of cattle-breed improvement. The predominant excuses include the relatively high care required for cross-bred cows, the need for continued cross-breeding programme since the quality is not maintained in subsequent generations and the lack of awareness and education in people (Sainath 2012; Ramdas and Ghotge 2006). Interestingly, all of these factors were applicable to hybrid crops as well, but they did not prevent their acceptance and spread (Koshy 2011).

It is necessary to differentiate between reasons and justification/excuses, which can be revealed only through insightful, evolutionary socio-economic investigation. Advancement in the field of technology needs to be accompanied by an equally intensive, scientific, unbiased and insightful research in peoples behaviour for a socially important policy to be successfully implemented over a large population like ours.

References

Bayani A, D Tiwade, A Dongre, A Dongre, R Phatak and M Watve (2016): Assessment of Crop Damage by Protected Wild Mammalian Herbivores on the Western Boundary of Tadoba-Andhari Tiger Reserve (TATR), Central India, PLOS One, 19 April, doi: 10.1371/journal.pone. 0153854.

Chako, C T (1994): Development of Sunandhini Cattle in India, World Animal Review, Food and Agricultural Organization of the United Nations, viewed on 14 July 2019, http://www.fao.org/docrep/t4650t/t4650t0v.htm.

DAHD (2012): 19th Livestock Census 2012: All India Report, Department of Animal Husbandry Dairying and Fisheries, Ministry of Agriculture, Government of India, New Delhi, viewed on 14 July 2019, http://dahd.nic.in/sites/default/filess/ Livestock%20%205_0.pdf.

(2013): Breeding Survey Book: Estimated Livestock Population Breed-wise: Based on Breed Survey 2013, Animal Husbandry Statistics Division, Government of India, New Delhi.

Directorate of Economics and Statistics (2014): Agricultural Statistics at a Glance (various issues), Department of Agriculture and Cooperation, Ministry of Agriculture, Government of India, New Delhi, viewed on 14 July 2019, https://eands.dacnet.nic.in/PDF/Agricultural-Statistics-At-Glance2014.pdf.

Heimpel, G E, J A Rosenheim and M Mangel (1996): Egg Limitation, Host Quality and Dynamic Behaviour by a Parasitoid in the Field, Ecology, Vol 77, No 8, pp 241020.

ISAAA (2014): Global Status of Commercialised Biotech/GM Crops: 2014, Brief 49, International Service for the Acquisition of Agri-biotech Applications, viewed on 14 July 2019, https://isaaa.org/resources/publications/briefs/49/default.asp.

Koshy, J (2011): How India Became a Bt Cotton Country, Livemint, 27 July, viewed on 28 July 2019, https://www.livemint.com/Opinion/ NZIDje22uiFUoskfs9FD5M/How-India-became-a-Bt-Cotton-country.html.

Kumarnath, K (2016): Bt Cotton: How It Flowered and Is Losing Lustre Now, Hindu BusinessLine, 22 March, viewed on 28 July 2019, .

Mazoomdaar, J (2013): The Desi Cow: Almost Extinct, Tehelka, Vol 10, No 5, viewed on 28 July 2019, http://old.tehelka.com/the-desi-cow-almost-extinct/.

McNamara, J M and A I Houston (1986): The Common Currency for Behavioural Decisions, American Naturalist, Vol 127, No 3, pp 35878.

Misra, S S (2007): Punjabs Spiritual Farming, Down to Earth, 30 November, viewed on 28 July 2019, https://www.downtoearth.org.in/coverage/punjabs-spiritual-farming-6918.

NDDB (2015): Operation Flood, National Dairy Development Board, viewed on 29 December 2016, http://www.nddb.org/about/genesis/flood.

Palekar, S (2007): The Techniques of Spiritual Farming, Amaravati, Maharashtra: Vedic Books.

Parker, G AandJ M Smith (1990): Optimality Theory in Evolutionary Biology, Nature, Vol 348,1 November, pp 2733, doi: 10.1038/348027a0.

Pingali, P L (2012): Green Revolution: Impacts, Limits and the Path Ahead, Proceedings of the National Academy of Sciences of the United States of America, Vol 109, No 31, July, pp 1230208.

PoliticalTruth (2016): Organic Farming: India Worlds Third Highest Producer of Organic Products, 13 February, viewed on 28 July 2019, https://politicaltruth.wordpress.com/2016/02/.

Ramdas, S R and N S Ghotge (2006): Indias Livestock Economy: The Forsaken Dry Lands, Seminar, Vol 564, August, viewed on 28 July 2019, http://www.india-seminar.com/2006/ 564/564_s_r_ramdas_&_n_s_ghotge.htm# top.

Roy, Deb R (1997): Communal Grazing Lands and Their Importance in India and Some Other Asian Countries, Session 18, Communal Grazing Lands, International Grassland Congress, Winnipeg, Manitoba.

Sainath, P (2012): Cattle Class: Native vs Exotic, Hindu, 6 January, viewed on 28 July 2019,https://www.thehindu.com/opinion/columns/sainath/Cattle-class-native-vs-exotic/article13355009.ece.

Samuelson, P and W Nordhaus (2001): Microeconomics (17th edition), Boston: McGraw-Hill.

Sharma, V, R V Singh, S Staal and C Delgado (2002): Critical Issues for Poor People in the Indian Dairy Sector on the Threshold of a New Era, June: Phase I of an IFPRIFAO project entitled Livestock Industrialisation, Trade and Social-Health-Environment Impacts in Developing Countries, viewed on 3 January 2017, http://www.fao.org/wairdocs/LEAD/X6115E/x6115e0b.htm.

Smith, E A and B Winterhalder (1992): Natural Selection and Decision Making: Some Fundamental Principles, Evolutionary Ecology and Human Behavior, E A Smith (ed), New York: Aldine de Gruyter, pp 2560.

Statista (2019): Cotton Production by Country Worldwide in 2017/2018, viewed on 5 July 2019, https://www.statista.com/statistics/263055/cotton-production-worldwide-by-top-countries.

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Watve, M, A Bayani and S Ghosh (2016): Crop Damage by Wild Herbivores: Insights Obtained from Optimisation Models, Current Science, Vol 111, No 5, pp 86167.

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Difference, Division, Desi Breeds : Intuitive Economics and the Outcome of an Operation - Economic and Political Weekly

TLR2 could be targeted to treat age-related macular degeneration – Drug Target Review

Scientists have implicated toll-like receptor 2 (TLR2) in age-related macular degeneration and shown that knocking it out can improve symptoms in animal models.

Researchers have shown that toll-like receptor 2 (TLR2) may play a role in age-related macular degeneration (AMD), the most common cause of central-vision blindness in adults. The scientists suggest targeting TLR2 in the eye may be a future therapy for AMD.

The paper, published in Cell Reports, stated that AMD is associated with two biological processes; uncontrolled oxidative stress resulting in the formation of a bleach-like chemical in the retina and the tagging of cell contents with complement protein. These tags signal for the elimination of the cell contents.

The scientists suggest in this paper that these two processes are linked by TLR2. Found on cell surfaces, TLR2 recognises chemical signals from bacterial infections in the environment outside the cell and activates the immune system.

In the case of the eye, TLR2 appears to act as a sensor of oxidative-stress, recognising a chemical pattern that is generated during oxidation, rather than infection and triggering a signal cascade that ends in promoting the laying down of complement, explained first author on the paper, Dr Kelly Mulfaul, from Trinity College Dublin, Ireland.

Dr Sarah Doyle, study leader and assistant professor of immunology at Trinity, said: A function for TLR2 has not previously been reported in retinal neurodegenerative disease pathology but it is likely to play an important role, because when we remove TLR2 from our experimental model systems we reduce the level of complement and this has the effect of protecting cells that are essential for vision from dying.

With the continual increase in life expectancy outpacing the rate at which drugs for age-related conditions are developed new avenues of therapy are badly needed, so the fact that blocking this single protein can have such a protective effect in the eye is a particularly exciting discovery.

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Growing Demand for Personalized Medicine Will Drives the Humanized Mouse and Rat Model Market – Press Release – Digital Journal

The Humanized Mouse Model Market is projected to reach USD 128.9 Million, at a CAGR of 9.9% during the forecast period.

This press release was orginally distributed by SBWire

Northrook, IL -- (SBWIRE) -- 02/24/2020 -- The key factors propelling the growth of the market are the increasing number of research activities involving humanized models, growing demand for personalized medicine, an increasing number of R&D activities in pharmaceutical and biotechnology companies, and continuous support in the form of investments and grants from the government and private sectors. The objective of the report is to define, describe, and forecast the humanized mouse model market size based on type, application, end-user, and region.

According to the new market research report "Humanized Mouse and Rat Model Market by Type (Genetic, Cell-Based (CD34, PBMC, BLT)), Application (Neuroscience, Hematopoiesis, Oncology, Immunology & Infectious Diseases) & End User (Pharmaceutical & Biotechnology Companies, CRO)) - Global Forecast", published by MarketsandMarkets.

The Humanized Rat Model market is expected to reach USD 8.9 Million by 2022 from USD 5.9 Million in 2017, at a CAGR of 8.4% during the forecast period.

Download PDF Brochure: https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=131763955

Market Segmentation in Detailed:

Based on type, the market is segmented into a humanized mouse and humanized rat. The Humanized mouse model market is further segmented into a cell-based and genetic-based humanized mouse model. The genetic humanized mouse models segment accounted for the largest share of the market. The large share of this segment can be attributed to the wide use of genetic humanized mouse models in the analysis of compounds, biological efficacy and safety testing, the study of drug metabolism and disposition, and investigation of immune system development and function.

Based on application, the market is segmented into oncology, immunology and infectious diseases, neuroscience, hematopoiesis, toxicology, and other applications. The oncology segment is expected to witness the highest growth, owing to the rising number of cancer research activities and increasing innovation to develop humanized mouse models tailored to meet the specific needs of cancer research.

Based on end-user, the market is segmented into pharmaceutical & biotechnology companies, contract research organizations (CROs), and academic & research institutions. The CROs segment is estimated to register the highest CAGR during the forecast period due to the growth in the number of pharmaceutical companies outsourcing their preclinical studies to CROs.

Worldwide Geographical Analysis:

The North American region is leading the humanized mouse models market is expected to account for the largest share of the market in 2017. Growth in this regional segment can primarily be attributed to growing biomedical research, preclinical activities by CROs and pharmaceutical R&D, continued and responsible use of animals ensured by animal care organizations, increasing monoclonal antibody production in the US along with growing stem cell research, and government support for the development of protein drugs in Canada

Request Research Sample Pages: https://www.marketsandmarkets.com/requestsampleNew.asp?id=131763955

Major Key Players Operating in Industry:

The Jackson Laboratory (US), Taconic Biosciences, Inc. (US), Horizon Discovery Group plc (UK), genOway, S.A. (France), Charles River Laboratories (US), Harbour Antibodies BV (China), Hera BioLabs (US), Vitalstar Biotechnology Co., Ltd. (China), inGenious Targeting Laboratory (US), AXENIS S.A.S (France), Crown Bioscience, Inc. (US), Transgenic, Inc. (Japan), and Champions Oncology, Inc. (US). The major players in the humanized rat models market include Horizon Discovery Group plc (UK), Hera BioLabs (US), and Yecuris Corporation (US).

For more information on this press release visit: http://www.sbwire.com/press-releases/release-1278836.htm

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Growing Demand for Personalized Medicine Will Drives the Humanized Mouse and Rat Model Market - Press Release - Digital Journal

Allakos Announces Multiple Presentations Related to Eosinophil and Mast Cell-Driven Diseases at the 2020 AAAAI Annual Meeting – GlobeNewswire

REDWOOD CITY, Calif., Feb. 24, 2020 (GLOBE NEWSWIRE) -- Allakos Inc. (the Company) (Nasdaq: ALLK), a biotechnology company developing antolimab (AK002) for the treatment of eosinophil and mast cell related diseases, today announced that the Company will present clinical and preclinical results in a number of diseases where mast cells and/or eosinophils have been shown to play a role in disease pathology. The presentations will take place at the 2020 American Academy of Allergy Asthma & Immunology (AAAAI) Annual Meeting being held in Philadelphia, Pa. from March 13 to 16, 2020.

Oral Presentations:

Featured Poster Presentations:

Poster Presentations:

Following the presentations, the posters will be available on the Allakos website.

About Allakos Allakosis a clinical stage biotechnology company developing antibodies that target immunomodulatory receptors present on immune effector cells involved in allergic, inflammatory, and proliferative diseases. The Companys lead antibody, antolimab (AK002), targets Siglec-8, an inhibitory receptor selectively expressed on human mast cells and eosinophils. Antolimab (AK002) has been shown to inhibit mast cells and deplete eosinophils. Inappropriately activated eosinophils and mast cells have been identified as key drivers in a number of severe diseases affecting the gastrointestinal tract, eyes, skin, lungs and other organs. Antolimab (AK002) has been tested in five clinical studies. In these studies, antolimab (AK002) eliminated blood eosinophils and improved disease symptoms in patients with eosinophilic gastritis and/or eosinophilic gastroenteritis, eosinophilic esophagitis, severe allergic conjunctivitis, chronic urticaria, and indolent systemic mastocytosis. For more information, please visit the Company's websiteat http://www.allakos.com

Source: Allakos Inc.

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Allakos Announces Multiple Presentations Related to Eosinophil and Mast Cell-Driven Diseases at the 2020 AAAAI Annual Meeting - GlobeNewswire

Infectious Immunology Market Overview and Forecast up to 2019 2027 – Jewish Life News

According to a report published by TMR market, the Infectious Immunology economy is expected to witness a CAGR growth of XX% within the forecast period (2019-2029) and reach at a value of ~US$ at the ending of 2029. The macro-economic and micro elements which are predicted to influence the trajectory of this market are studied in the presented market study.

Light on the raw material throws Suppliers, vendors, manufacturers, and market consumers at the markets value chain. Furthermore, the political and economic scenarios of regions and its effect on the Infectious Immunology market are discussed within the accounts.

Critical Insights enclosed from this report:

Request Sample Report @ https://www.transparencymarketresearch.co/sample/sample.php?flag=B&rep_id=2929

Competitive Outlook

Light onto the throws Business prospects of prominent players operating from the Infectious Immunology sector. The item pricing plans, marketing stations that were preferred , product portfolio of most players, and promote presence of each and every company is contained in the report. The dominant players covered in the report include Business, Business two, Business 3, and Company 4.

Regional Assessment

The presented market study sheds light on the Marketplace Scenario in various markets. Furthermore, the governmental and regulatory policies to the prospects of the Infectious Immunology market in each regions effect is analyzed in the report.

market segments, major geographies, and current market trends. Geographies analyzed under this research report include

This report is a complete study of current trends in the market, industry growth drivers, and restraints. It provides market projections for the coming years. It includes analysis of recent developments in technology, Porters five force model analysis and detailed profiles of top industry players. The report also includes a review of micro and macro factors essential for the existing market players and new entrants along with detailed value chain analysis.

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Infectious Immunology Market Overview and Forecast up to 2019 2027 - Jewish Life News

Harvard Scientists to Collaborate with Chinese Researchers to Improve Diagnostics and Develop Novel Coronavirus Therapies | News – Harvard Crimson

A team of Harvard scientists will collaborate with a Chinese research institute in a five-year effort to study the novel coronavirus, which has infected more than 78,000 people worldwide, according to a University press release Monday.

Co-led by Harvard Medical School Dean George Q. Daley and Zhong Nanshan the head of an expert team within Chinas National Health Commission that is investigating the outbreak the partnership will focus on creating more accurate diagnostic tests and designing vaccines, antiviral therapies, and treatments. Members of the group have held two video chats since its formation to begin the partnership, according to University spokesperson Jason A. Newton.

According to the press release, Daley said that the Medical School is uniquely positioned to bring together experts in virology, infectious diseases, structural biology, pathology, vaccine development, epidemiology, and public health for the project.

Harnessing our science to tackle global health challenges is at the very heart of our mission as an institution dedicated to improving human health and well-being worldwide, he said in the release.

The two research partners will share $115 million in funding from China Evergrande Group, a real estate giant and Fortune Global 500 company.

Zhong gained international recognition for his work combatting the 2003 Severe Acute Respiratory Syndrome outbreak. He was also the first scientist to publicly confirm human-to-human transmissibility during 2019s n-Cov epidemic.

We are extremely encouraged by the generous gesture from Evergrande to coordinate and support the collaboration and by the overwhelmingly positive response from our Harvard colleagues, Zhong said in the press release.

We look forward to leveraging each of our respective strengths to address the immediate and longer-term challenges and a fruitful collaboration to advance the global well-being of all people, he added.

Hui Ka Yan, who chairs China Evergrande Group, said in the press release that the company is honored to work to stop the outbreak. The groups CEO, Xia Haijun, visited University President Lawrence S. Bacow in Cambridge last Wednesday, according to a statement from the company.

Evergrande is honored to have the opportunity to contribute to the fight against this global public health threat, Hui Ka Yan said in Harvards press release. We thank all the scientists who responded so swiftly and enthusiastically from the Harvard community and are deeply moved by Harvard and Dr. Zhongs teams dedication and commitment to this humanitarian cause. We have the utmost confidence in this global collaborative team to reach impactful discoveries against the outbreak soon.

Bacow said in the release that the collaborators are confident that their work will contribute valuable discoveries to broader global efforts to combat coronavirus.

We are grateful for Evergrandes leadership and generosity in facilitating this collaboration and for all the scientists and clinicians rising to the call of action in combating this emerging threat to global well-being, he said.

Harvard affiliates participating in the effort include Daley; Medical School Dean for Research Operations and Global Programs David E. Golan; Immunology department chair Arlene H. Sharpe; Medicine professor Bruce D. Walker; Harvard School of Public Health Center for Communicable Disease Dynamics director Marc Lipsitch; and Lindsey R. Baden, the director of clinical research in Brigham and Womens Hospitals Division of Infectious Diseases.

Staff writer Michelle G. Kurilla can be reached at michelle.kurilla@thecrimson.com. Follow her on Twitter @MichelleKurilla.

Staff writer Ruoqi Zhang can be reached at ruoqi.zhang@thecrimson.com. Follow him on Twitter @RuoqiZhang3.

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Harvard Scientists to Collaborate with Chinese Researchers to Improve Diagnostics and Develop Novel Coronavirus Therapies | News - Harvard Crimson

Missouri S&T News and Events A heart and soul for research – Missouri S&T News and Research

Nuran Ercal could easily be called the backbone of biochemistry at Missouri S&T. Named the Richard K. Vitek/Foundation for Chemical Research Endowed Chair in Biochemistry in 2009, Ercal combines academic expertise from analytical and environmental chemistry, biological sciences, and chemical and biological engineering to make significant and collaborative contributions to science.

Ercals been researching treatments for oxidative stress-related diseases since 1995, focusing on the role of glutathione (GSH), an especially powerful and versatile antioxidant that the body is normally able to generate on its own. Decreased GSH levels are associated with a wide variety of medical conditions, like lead toxicity, medicinal drug-induced toxicity (e.g., liver damage from Tylenol overdose), radiation exposure, alcohol abuse and neurogenerative disorders. Her teams research has shown that antioxidant drugs with the ability to preserve or restore GSH levels may be effective in treating these conditions.

For the last 10 years, Ercals primary research interest has been the non-invasive pharmaceutical treatment of cataracts and other degenerative eye disorders caused by oxidative stress.

Ercal is one of the earliest S&T faculty members to receive research funding from the National Institutes of Health (NIH). Her NIH funding is ongoing, and subsequent awards total over $1.5 million. In August, she received nearly $400,000 from the National Eye Institutes (NEI) of the NIH to study nanodiamonds for antioxidant delivery.

Working with others from S&TVadym Mochalin, associate professor and a physical and materials chemist; post-doctoral fellow Annalise Pfaff; doctoral students Justin Beltz and Ibrahim Abdullahi the team is combining their disciplines to test a nanodiamond delivery platform for slow-release antioxidant eyedrops to prevent cataracts.

A major challenge in developing an effective eyedrop-based treatment is getting the drug to stay in the eye long enough to work, says Beltz. With nanodiamonds as the delivery platform, were breaking new ground toward a solution.

Ercals long-term objective is to develop a topical antioxidant drug to halt or significantly delay the progression of cataracts. The study will run three years, starting with testing on human cell models and progressing to animal studies. Ercal is also collaborating on traumatic brain injury research projects funded by the U.S. Army Leonard Wood Institute.

During her nearly 30 years at S&T, Ercal has advised 20 Ph.D. and 11 masters students. She also teaches General Biochemistry and upper-level courses Biochemical Metabolism and Neurochemistry with Clinical Correlations. She says shes particularly enthused about her current researchteams capabilities.

I dont look when Im running, I just run, she says. I dont calculate. Imdoing what I loveresearch and teaching.

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Missouri S&T News and Events A heart and soul for research - Missouri S&T News and Research