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UConn Professor Wins Award For Scholarship and Mentoring – UConn Daily Campus

The Mary S.EskineAward was created in honor of a former professor at Boston University who died from breast cancer in 2007 for her work in neuroscience and position as the Director of Undergraduate Research at Boston University. The award is given to professors nominated by their students for advocating undergraduate research and mentoring.

I have twoPhD students and 13 undergraduatestudents in my lab and,unknown to me, they and former students nominated me for this award, Dr. Markus said.

Dr. Markus research focuses on the development of memories using rats. His team monitorsthe rats brain cells, or neurons, while at restand while performing tasks such as running a maze. This data comes from the hippocampus, a region of the brain that is important for memory and spatial awareness.

Thomas Shao, an eighth-semester physiology and neurobiology major who does research with Dr. Markus, summarizes the research as the following, How do our experiences turn into a memory, what are the [neuronal] processes that go into observational learningand how do the different parts of the brain interact in order for us to perform spatial and motorresponses?

Thumbnail photo courtesy of Markus Lab at the University of Connecticut website.

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UConn Professor Wins Award For Scholarship and Mentoring - UConn Daily Campus

Five Inspiring Creators Working In The Immersive Industry – Forbes

International Womens Day (IWD) is celebrated on March 8 each year to highlight the achievements of women all over the world.

Every day Im introduced to brilliant women who are pushing boundaries in the immersive space and creating the future. To mark International Womens Day, I wanted to highlight a few of these creators that inspire me and my team.

Sally Slade, LA, California

As the lead AR/VR developer at LA-based Magnopus, Slade envisions crossovers between the digital and physical worldsthen she makes them a reality. She started her career in the visual effects industry but got hooked on VR after trying Tilt brush and painting in 3D.

Slade has released four titles to Microsoft HoloLens including Muralize, an app that projects holographic images that users can trace to make large-scale art. Slade was also a developer on the Emmy-nominated experiences Mission: ISS and Coco VR.

Magnopus

Amy Robinson Sterling, Cambridge, Massachusetts

Robinson is the Executive Director of EyeWire and Neo, games to map the brain. EyeWire crowdsources neuroscience. It challenges hundreds of thousands of players around the world to solve 3D puzzles and map out neurons, allowing neuroscientists to chart synaptic connections among neurons and begin to decipher the mysteries of how we see. EyeWire is the first of many games that will invite the world to make discoveries about how the brain works.

Under Robinsons leadership, EyeWires neuroscience visualizations have appeared at TED, the United Nations and in Times Square NYC. She produced the worlds first neuroscience virtual reality experience and curates the NIH 3D Print Exchange Neuroscience collection.

Amy-Robinson-Sterling

Chantal Matar, London, England

London-based architect and designer, Matar has collaborated with International Architectural firms, such as The Prince's Foundation, Anouska Hempel Design, and Bernard Khoury Architects.

Since 2018, Matar has been working at Zaha Hadid Architects as a Senior Designer, overseeing high-end international projects in different stages. Recently, she has grown an interest in generative and new media art and has participated in various video mapping competitions as a means of artistic expression.

@chantal.matar on Instagram

Anna Zhilyaeva, Marseille, France

Zhilyaeva is a virtual reality artist. She uses Tilt Brush to entertain, inspire and break the boundaries of traditional art. Recently, she opened Worldskills 2019 in Kazan with a virtual reality painting performance. She applies her background in traditional art to create 3D work, with a mission to evoke mystery and love. Clients and partners have included HTC Vive, Google, IBM, and Microsoft. Her work can be found on her YouTube channel.

Holger Jacobs/ kultur24.berlin

Sara Thacher, Glendale, California

Thacher is a creative director and experience designer making immersive and playful experiences for Walt Disney Imagineering. Her adventures often meander between the physical and digital.

Before Disney, Thacher worked as an independent designer and producer working with clients such as No Mimes Media, Thomas Dolby, ZER01 and Meet Gatsby. She was also the Lead Producer and Experience Designer for the alternate reality game The Jejune Institute.

Sara thacher / ucla

The theme for this years IWD is #EachforEqual, focusing on creating a world that is gender equal that enables economies and communities to thrive. If youd like to get involved with supporting the IWD Community, head over to the website.

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Five Inspiring Creators Working In The Immersive Industry - Forbes

New Jersey Health Foundation grants advance research – Rowan Today

Ghulam Rasool envisions an improved bionic arm and hand that is more functional and affordable than those already on the market.

Now, Rasools evolving research is getting a boost.

Rasool, an assistant professor of Electrical and Computer Engineering, is one of seven Rowan faculty members who recently received funding from the New Jersey Health Foundation for health-related research. Nearly 23 percent of the foundations latest grants were awarded to Rowan faculty.

The Princeton-based nonprofit supports faculty and student researchers at New Jersey-based organizations with financial resources. The grants help researchers move their projects out of the lab and into the real world, said Beena Sukumaran, vice president for research at Rowan.

Theyre taking their research and applying it to real life, she said.

Rasools project would create a prosthetic limb that combines neuroscience with practicality.

The user would be able to control the wrist joint and finger of the hand by just thinking about what theyre trying to do, Rasool said. The idea is that when someone gets an amputation, the limb may be lost. However, the neurons that connect the brain to the limb may still be there.

What we can do is tap into those neurons and get access to the electrical signals coming from the brain to muscles. We can use these electrical signals and learn about the movement the person was trying to perform or was just thinking about.

This is the second consecutive year Rasool has received a $35,000 grant from the foundation for his research.

In the first year of Rasools project, known as EnaBLe (for enhanced bionic limb), he and his student researchers built prototypes of the bionic arm. This year, they hope to discover how the bionic arm can mimic human movements in the non-amputee population. In 2021, Rasool and the students will begin working with forearm amputees to test the device.

Grant funding is vital, Rasool said.

Working with students, their stipends, equipment and lab space, all of these things require continued financial support, Rasool said.

Without these grants, awards and financial support for research, Rasool added, we wouldnt be able to make progress.

In addition to Rasool, the following faculty received grants from the foundation:

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New Jersey Health Foundation grants advance research - Rowan Today

Researchers Discover Role in the Emotional Brain for Neurotransmitter – Technology Networks

A new neurotransmitter system in the brain has been discovered by an international group of researchers led by Professor Raul R. Gainetdinov, the director of the Institute of Translational Biomedicine and academic supervisor of the Clinic of High Medical Technologies of St Petersburg University. Within this system, the transmission of signals between neurons in the brain occurs via the trace amine-associated receptor 5 (TAAR5). The results of the study will allow the development of new types of drugs for depression, schizophrenia and anxiety disorders. An academic paper describing the discovery has been published in the journal Frontiers in Molecular Neuroscience.

Neurotransmitters are chemicals that transmit signals between neurons or from neurons to other cells. They interact with specific receptors found in the brain of humans and animals, controlling a variety of biological processes, e.g. fear, anger, pleasure, memory, energy, appetite and sleep. Today, scientists know various types of neurotransmitter systems: dopamine, norepinephrine, serotonin, histamine, glutamate, and many others. A large number of clinically used drugs for many brain disorders is based on the action on these systems.

The St Petersburg University researchers, together with colleagues from the Istituto Italiano di Tecnologia (Genova, Italy) and the Pavlov First St Petersburg State Medical University (St. Petersburg, Russia) conducted experiments on mutant mice. They were able to show that there is a novel neurotransmitter system in the brain - in it, signal transmission of innate olfactory information into the "emotional" brain areas occurs via the trace amine-associated receptor 5 TAAR5.

'Trace amines are cousins of well-known neurotransmitters dopamine and serotonin,' explains Raul Gainetdinov. 'It is known that humans have six subtypes of trace amine-associated receptors that sense trace amines. The TAAR1 receptor is the best investigated, and it is considered so promising that in May 2019, the FDA (Food and Drug Administration, the agency of the US Department of Health and Human Services, which approves the launch of new drugs on the market) designated the experimental drug based on action on TAAR1 of Sunovion Pharmaceuticals the status of "breakthrough treatment" for schizophrenia. Since the FDA accepted the second stage of the clinical trial of their medication for schizophrenia as the third stage, the drug should enter the market within a few years. This should be the first antipsychotic drug in the world that is not a dopamine receptor blocker. It is worth noting that researchers of the St. Petersburg State University are also developing new drugs based on the action on TAAR1.'

Researchers drew attention to another trace amine-associated receptor, TAAR5. It was previously believed that all other receptors for trace amines, with the exception of TAAR1, are exclusively olfactory and participate only in the perception of socially-relevant innate odours (for example, the smell of rotten tissue, predators or pheromones). Therefore, it is believed that they are not useful in the search for novel cures for brain diseases. However, the St. Petersburg State University scientists were convinced of the contrary: to prove the important role of TAAR5 in the neuronal functions and psycho-emotional state, they conducted a series of experiments with knockout laboratory mice - the gene encoding the TAAR5 protein was "knocked out" or "turned off" in these animals. Instead, a marker was inserted into the genome, which allowed the researchers to see in which areas of the brain this protein is present.

'It turned out that TAAR5 is found not only in the nose and olfactory bulb, but also in the "emotional" brain areas associated with the olfactory system: the amygdala, hippocampus, thalamus and other structures,' said Professor Gainetdinov. In addition, we observed that the lack of TAAR5 results in the alteration of the concentration of serotonin in the brain, and this is the major indicator of changes in emotional behaviour. Finally, knockout mice without TAAR5 behave as if they are under the treatment with antidepressants or anti-anxiety drugs: they are not afraid of bright light and are not amenable to stress.

Preliminary data also suggest that all other trace amine-associated receptors are not only mediators of the innate olfactory function, but are also variously involved in the regulation of the psycho-emotional state. According to Raul Gainetdinov, this discovery can result in the development of fundamentally new drugs that can deal with schizophrenia, depression, anxiety disorders, various addictions, possibly even Parkinson's disease and Alzheimer's disease. The data obtained may have impact to various fields of neuroscience, psychiatry, psychology, and even aromatherapy.

'Now we have to search for effective antagonists - substances that will block TAAR5 receptors in the brain, thereby exerting an antidepressant and anti-anxiety effect,' said Raul Gainetdinov. 'Our laboratory at the St Petersburg University has essentially everything for these studies: we have developed a test system for searching for drugs that activate or block TAAR5 and other receptors; and we also have a unique collection of knockout animals for all receptors for trace amines. We hope to find the support of industrial partners with whom we will be able to develop innovative drugs that no one has created yet. So far, we have investigated only one receptor, TAAR5, which has been previously considered to be an exclusively olfactory receptor. We are performing now studies of four other trace amine-associated receptors, which can open new unexpected directions in the pharmacology of various brain diseases.'

Reference: Espinoza, S., Sukhanov, I., Efimova, E. V., Kozlova, A., Antonova, K. A., Illiano, P., Leo, D., Merkulyeva, N., Kalinina, D., Musienko, P., Rocchi, A., Mus, L., Sotnikova, T. D., & Gainetdinov, R. R. (2020). Trace Amine-Associated Receptor 5 Provides Olfactory Input Into Limbic Brain Areas and Modulates Emotional Behaviors and Serotonin Transmission. Frontiers in Molecular Neuroscience, 13. https://doi.org/10.3389/fnmol.2020.00018

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Researchers Discover Role in the Emotional Brain for Neurotransmitter - Technology Networks

Study Finds That Community Treatment Orders Do Not Reduce Hospital Readmission Rates or Stays – Global Health News Wire

This research finds that CTOs are associated with an increased risk of readmission as well as increased time spent in psychiatric hospitals

In the first large, observational study with a control group in England and Wales, research funded by the NIHR Maudsley Biomedical Research Centre has found that Community Treatment Orders (CTOs) are associated with an increased risk of readmission as well as increased time spent in psychiatric hospitals, contrary to results from previous uncontrolled studies. Researchers suggest that these findings should be considered in future reforms to the UK Mental Health Act.

CTOs were introduced in England and Wales under the 2007 amendment to the Mental Health Act (1983). They are a legal order for compulsory monitoring and treatment of people discharged from psychiatric hospitals with serious mental disorders within a community care setting. They also allow quicker readmission to hospital, if necessary, following suspected relapse. Their use has exceeded initial expectation and 5,000 are now used in England each year on average.

Researchers compared 830 patients who were discharged on a CTO with 3,659 patients discharged to voluntary community mental healthcare. Results showed that in the two years following discharge from psychiatric hospital, patients on CTOs spent, on average, 17.3 additional days in hospital and had a 60% greater rate of readmission compared to patients receiving voluntary care. The study also found that the average CTO lasted three years, more than four times longer than initial government projections of nine months.

These findings are contrary to previous uncontrolled observational studies carried out in the UK and Wales, some of which reported a reduction in readmission rates in patients on CTOs. However, the addition of a control group of patients discharged without a CTO in this study allowed researchers to compare outcomes more robustly than in previous studies.

These results could be due to the tendency for patients with CTOs to have historic relapses and severe symptoms, or due to the ease of readmission through the CTO pathway.

Lead author Dr. Rashmi Patel, MRC UKRI Health Data Research UK Fellow at the Institute of Psychiatry, Psychology & Neuroscience at Kings College London, said: Community Treatment Orders were designed to prevent relapse and readmission to hospital for people with serious mental illnesses. In fact, our study suggests that they have the opposite effect, with people on CTOs being more likely to be readmitted and spending longer in hospital. In light of these findings, we need to think carefully about what role (if any) CTOs should play in providing care to people with serious mental illnesses.

Co-author Dr. Alexis Cullen, Research Fellow at the Institute of Psychiatry, Psychology & Neuroscience at Kings College London added While we cannot establish a causal effect of CTOs on readmission rates, our findings concur with smaller randomised controlled trials from the UK in showing that readmission rates are not reduced. Importantly, our inclusion of patients treated in forensic psychiatric settings (who have been excluded from previous studies) means that our sample is more reflective of the patients who typically receive these treatments.

Researchers used the Clinical Record Interactive Search (CRIS) system which has access to over 400,000 anonymised electronic health records from the South London and Maudsley NHS Foundation Trust. Records available from patients who were discharged between 2008 and 2014 under the Mental Health Act were analysed.

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Study Finds That Community Treatment Orders Do Not Reduce Hospital Readmission Rates or Stays - Global Health News Wire

Susan Hockfield Elected to Pfizer’s Board of Directors – BioSpace

NEW YORK--(BUSINESS WIRE)--Pfizer, Inc.. (NYSE: PFE) today announced the election of Dr. Susan Hockfield to its Board of Directors, effective immediately. Dr. Hockfield, age 68, was also appointed to the Regulatory and Compliance Committee and the Science and Technology Committee of Pfizers Board.

Dr. Hockfield is Professor of Neuroscience and President Emerita at the Massachusetts Institute of Technology (MIT). She served as MITs sixteenth president from 2004 to 2012 and was the first woman and the first life scientist to lead MIT. She is also a member of the Koch Institute for Integrative Cancer Research at MIT. Prior to joining MIT, she was the William Edward Gilbert Professor of Neurobiology, Dean of the Graduate School of Arts and Sciences from 1998 to 2002 and Provost from 2003 to 2004 at Yale University.

She is also a member of the American Association for the Advancement of Sciences (where she served as President-elect, President and Chair), the American Academy of Arts and Sciences, and the Society for Neuroscience.

Dr. Hockfield served as Science Envoy with the U.S. Department of State and as a member of a Congressional Commission evaluating the Department of Energy laboratories.

She served as a Director of General Electric Company from 2006 until 2018 and Director of Qualcomm from 2012 until 2016.

Dr. Hockfield received a B.S. in Biology from the University of Rochester and a Ph.D. in Anatomy and Neuroscience from Georgetown University School of Medicine.

We are fortunate to welcome Dr. Susan Hockfield to Pfizers Board of Directors, said Albert Bourla, Chairman and Chief Executive Officer, Pfizer. We continue to infuse our Board with scientific expertise in support of our strategic focus on innovation and advancing our pipeline. As a distinguished neuroscientist and highly respected academic leader, Dr. Hockfield will bring tremendous value to the company and our shareholders.

About Pfizer: Breakthroughs That Change Patients Lives

At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products, including innovative medicines and vaccines. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. Consistent with our responsibility as one of the world's premier innovative biopharmaceutical companies, we collaborate with health care providers, governments and local communities to support and expand access to reliable, affordable health care around the world. For more than 150 years, we have worked to make a difference for all who rely on us. We routinely post information that may be important to investors on our website at http://www.Pfizer.com. In addition, to learn more, please visit us on http://www.Pfizer.com and follow us on Twitter at @Pfizer and @Pfizer News, LinkedIn, YouTube and like us on Facebook at Facebook.com/Pfizer.

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Susan Hockfield Elected to Pfizer's Board of Directors - BioSpace

Understanding How the Brain Predicts Could Give Autism Insight – Technology Networks

Our brains make our lives easier by predicting what will happen next based on previous experiences. But what happens when those predictive powers dont work like they should?Autism spectrum disorder and other neurological disorders involve problems with brain prediction. For example, the brain usually remembers situations that can become dangerous such as a hot stove or a car coming toward you while youre crossing the street. For someone with autism, the brain cant always predict those things.

A professor at Purdue University is discovering how complications with prediction lead to changes in sensory perception and learning impairments, both of which are common symptoms of autism.

The brain precomputes everything, said Alexander Chubykin, assistant professor of biological sciences. When you see something familiar, it immediately tries to remember what it is and thats how we know what will happen next. My lab is trying to understand how the brain distinguishes between something that is familiar and novel and how that plays into neurological disorders.

Through his research, Chubykins goal is to work on developing new biomarkers to make diagnosing disorders such as autism easier and make advancements toward discovering potential new drugs for treatment.

Understanding how the brain predicts future events is critical when it comes to defining and understanding neurological disorders, Chubykin said. Its also a key to survival and normal brain function.

If you see something dangerous, your brain usually recognizes that and predicts something bad could happen. Chubykin said. If you have this previous experience and can process this information, you can escape in time. When your brain cant tell you those things, its overwhelming and frightening.

Chubykin says understanding how the brain decides what it should pay attention to in the first place is key to understanding how prediction plays a role in disorders such as autism. In order for the brain to decide what is novel, it needs to first recognize a sensory stimulus. Recognition of the familiar stimulus leads to a generation of an expectation or prediction. However, when a prior expectation is violated, that leads to a surprise. These surprises are called prediction errors, which is when the senses do not correspond to the brains predictions.

When the brain receives surprises, it then wants to minimize that surprise in the future by memorizing it and the corresponding environment, a process otherwise known as learning.

We continually receive new sensory information, and we learn it, Chubykin said. But for someone with a disorder such as autism, its not that easy. In autism, the brain cant always accurately predict what will happen in the near future from senses such as vision, touch, and hearing.

Thats why people affected by autism often experience sensory overload, which is when sensory input overrides prediction. Sensory overload can cause stress and makes it difficult to focus.

For instance, if I have an umbrella sitting in the corner of my office and I see it every day, my brain knows its going to be there and its not a surprise, Chubykin said. I get used to it being there. But for patients with autism, it might take them a while to process it. It may also take them longer to get used to new environments with a lot of new sensory stimuli, and its these details that overwhelm them.

Chubykin also led recently published research that revealed mice can perceive so-called Kanizsa optical illusions and the neural mechanisms that are involved.

Patients with autism and schizophrenia typically have difficulty perceiving this illusion, Chubykin said. This could be significant for diagnostic testing of early detection of autism and schizophrenia in the future. The reason for that is that this illusion tests the ability to do spatial prediction.

He says in schizophrenia, prediction also is impaired, but it is the complete opposite of autism.

For patients with schizophrenia, their brains have a higher emphasis on prediction compared to senses, Chubykin said. When theyre hallucinating or hearing voices, their internal predictions override their senses.

Chubykin wants his research to provide answers for both patients and their families. The earlier these disorders can be diagnosed, the quicker patients can get the help they need.

The more we learn, the more we can help, Chubykin said.ReferencePak et al. (2020) Top-Down Feedback Controls the Cortical Representation of Illusory Contours in Mouse Primary Visual Cortex. The Journal of Neuroscience. DOI: https://doi.org/10.1523/JNEUROSCI.1998-19.2019

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Understanding How the Brain Predicts Could Give Autism Insight - Technology Networks

Hormone Linked to Pain Difference Between Men and Women – Technology Networks

Imagine taking a pill to control your pain and, instead, the medication actually increases the pain you feel. That may be the situation for patients who take opioids, but even more so for women, according to groundbreaking research by investigators at the University of Arizona College of Medicine Tucson in the Department of Pharmacology.The researchers identified a mechanism that explains why women may be more vulnerable than men to develop pain in general, as well as to develop pain from opioids specifically.

The cause is a neurohormone, prolactin, known largely for promoting lactation in expectant mothers in their final months of pregnancy and after childbirth.

Frank Porreca, PhD, associate department head, a professor of Pharmacology, anesthesiology, cancer biology and neuroscience at the college, and senior author on the study, notes it always has been understood that women experience some types of pain that occur without injury (known as functional pain syndromes) more than men. The reasons for this never were clearly understood. A possible explanation the researchers explored was the differences in the cells and nerves that send pain signals to the brain in women and men.

Now, their paper pinpoints these sex differences to the prolactin receptor, which regulates sensitization of nociceptors neurofibers that conduct pain impulses and pain from opioids (opioid-induced hyperalgesia) selectively in female laboratory mice. The second point is important, Dr. Porreca explains, because they found opioids also produce a release of prolactin in women that in turn increases pain instead of lessening it.

The findings suggest new pain-management therapies targeting the prolactin system would greatly benefit women suffering from functional pain syndromes.

Of all these female-prevalent pain disorders, migraines are among the most common, with about 35 million migraine patients in the United States, and three out of four of those are women. In addition, in fibromyalgia patients, as many as nine out of 10 are women; for irritable bowel syndrome, three out of four are women. When you add up all those women with pain if you can normalize that this would provide a huge and important impact on medical care, Dr. Porreca says.

In that context, he adds, being female can be considered a risk factor for increased pain. Now, they know one important reason why. Nobody's ever understood this until now, Dr. Porreca says.

He points out many of these pain spells are intermittent and associated with triggering events. For instance, he and his colleagues found stress releases prolactin and unexpectedly promotes pain selectively in females.

These triggering events can be wide-ranging. They can include things like alcohol, fatigue and sleep disruption. But stress is the most common trigger self-identified by patients. That's where we started our studies how does stress contribute to female-specific pain or female-selective pain?

Primary authors on the paper include: Yanxia Chen, a graduate student in Dr. Porrecas lab; Aubin Moutal, PhD, a research assistant professor in the Department of Pharmacology, working in the lab of Rajesh Khanna, PhD, a UArizona professor of anesthesiology, pharmacology and neuroscience, who also is a co-author on the paper; and Edita Navratilova, PhD, an assistant professor of pharmacology.

Dr. Navratilova says dopamine D-2 receptor agonist drugs that limit prolactin release, such as cabergoline, commonly are used for other diseases, and are not addictive. These drugs, possibly in conjunction with other classes of medications, may help treat those pain conditions in women more effectively without the addictive properties of opioids.

If we could just reduce the proportion of women who have migraines to the same amount as in men, that would be quite revolutionary, Dr. Navratilova says.

In addition, since publication of their findings, Dr. Porreca has been contacted by companies interested in investigating whether an antibody previously associated with breast cancer treatment might be able to be engineered as a therapy to guard against pain in women.ReferenceChen et al. (2020) The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females. Science Translational Medicine. DOI: https://doi.org/10.1126/scitranslmed.aay7550

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Hormone Linked to Pain Difference Between Men and Women - Technology Networks

Neuroscience Antibodies & Assays Market 2020 | Applications, Challenges, Growth, Shares, Trends and Forecast To 2026 – Packaging News 24

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Neuroscience Antibodies & Assays Market was valued at USD 2.42 Billion in 2018 and is projected to reach USD 5.14 Billion by 2026, growing at a CAGR of 9.7% from 2019 to 2026.

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TAGS: Neuroscience Antibodies & Assays Market Size, Neuroscience Antibodies & Assays Market Growth, Neuroscience Antibodies & Assays Market Forecast, Neuroscience Antibodies & Assays Market Analysis, Neuroscience Antibodies & Assays Market Trends, Neuroscience Antibodies & Assays Market

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Neuroscience Antibodies & Assays Market 2020 | Applications, Challenges, Growth, Shares, Trends and Forecast To 2026 - Packaging News 24

The Mind Is the Opposite of a Computer – Walter Bradley Center for Natural and Artificial Intelligence

Matthew Cobb (right) is a British neuroscientist who blogs on occasion on Darwinian evolutionary biologist Jerry Coynes Why Evolution is True blog. Despite this inauspicious hobby, he has written a good essay in The Guardian, Why your brain is not a computer on the shortcomings of the computational model of the brain:

And yet there is a growing conviction among some neuroscientists that our future path [to understanding how the brain works] is not clear. It is hard to see where we should be going, apart from simply collecting more data or counting on the latest exciting experimental approach. As the German neuroscientist Olaf Sporns has put it: Neuroscience still largely lacks organising principles or a theoretical framework for converting brain data into fundamental knowledge and understanding. Despite the vast number of facts being accumulated, our understanding of the brain appears to be approaching an impasse.

So true. Philosopher Roger Scruton (19442020) said it best (I paraphrase): neuroscience is a vast trove of answers with no memory of the questions. Cobb continues:

For more than half a century, [neuroscience has been] framed by thinking that brain processes involve something like those carried out in a computer. But that does not mean this metaphor will continue to be useful in the future. At the very beginning of the digital age, in 1951, the pioneer neuroscientist Karl Lashley argued against the use of any machine-based metaphor.

Descartes was impressed by the hydraulic figures in the royal gardens, and developed a hydraulic theory of the action of the brain, Lashley wrote. We have since had telephone theories, electrical field theories and now theories based on computing machines and automatic rudders. I suggest we are more likely to find out about how the brain works by studying the brain itself, and the phenomena of behaviour, than by indulging in far-fetched physical analogies.

Cobb is rightmodels of the brain tend to track with the latest technology. To some ancient philosophers, the brain worked by making heat, like a fire. To Descartes the brain was hydraulic. To 19th century materialists, writing amid the Industrial Revolution, the brain was a machine. To 21st century materialists, the brain is a computer. Our tools at hand become our metaphors.

But metaphors are not metaphysics. Often, metaphors lead us astray. In some sense, the atom is like a little solar system, with electrons orbiting the nucleus like planets orbiting the sun. But quantum mechanics revealed dynamics utterly unlike the solar system model of the atom pictured by early twentieth century pioneers in the field like Ernest Rutherford and Niels Bohr.

Similarly, the eye is in some ways, like a camera. But if you understood only cameras and did not understand ocular physiology and neurophysiology, you will understand pitifully little about the eye.

So, what is the brain? How does it work? As Scruton noted, we need to make the questions more clear. Several questions are embedded in the issues Cobb raises.

One at a time:

1.Is the brain a kind of computer? First and foremost, the brain is an organ and it does organ thingsit metabolizes, secretes, generates action potentials and neurotransmitters, etc. But is it also a computer?

The answer depends on how you define computation. If computation is the mapping of an input to an output according to a set of rules (which is the usual broad definition of computation), then some aspects of brain function are computation. There are inputs (sensory inputs, electrical and chemical stimuli, etc.) and these inputs are in some situations mapped to outputs (transmission of action potentials, secretion of neurotransmitters, reflexes, etc.) according to rules (neurophysiological principles). Perhaps this application of computation to brain function is trivial, perhaps not, but in this sense some aspects of brain function are computational.

As well see below, however, not all aspects of brain function are computational, so the brain cannot be described entirely as a computer. And I would point out to Cobb (who is a materialist and atheist) that computation intrinsically entails teleology which (by Aquinas Fifth Way) demonstrates the existence of God. Atheists should be careful about computational models in biology, because computation is the product of intelligent design. Computers and software dont just happen by themselves.

2.What is the relation between the brain and the mind? Cobb is a materialist so I presume he discounts dualism. However, abstract thought (as classical philosophers pointed out) is inherently an immaterial ability and thus it cannot arise from the brain or from any material organ. Concrete thought can be material in origin but that view presupposes a metaphysical understanding of matter that is considerably more sophisticated than Cobbs materialism. Hylemorphism is the best metaphysical perspective from which to understand the material and immaterial powers of the mind.

3. Is the mind a kind of computation? No. In fact, the mind is the antithesis of computation. The reason is obvious when you think about it. Mental activity always has meaningevery thought is about something. Computation always lacks meaning in itself. A word processing program doesnt care about the opinion that youre expressing when you use it. A digital camera doesnt care what youre taking a picture of. In fact, the great utility of computation is that it doesnt have its own meaning so you can use it as a substrate to express any meaning you choose. Because the mind always has meaning and computation never has meaning, the mind is not computation. In fact, the mind is the opposite of computation.

Succinctly, the brain is an organ and some of its functions can be described as computation. The mind is obviously related to the brain but the relationship is complex and is best understood from the perspective of hylemorphic metaphysics. Concrete thought arises from brain function but abstract thought is inherently immaterial. Although abstract thought is influenced by brain function, it does not arise from it. The mind itself (as distinct from the brain) is no form of computation, and in fact the mind is the antithesis of computation.

Cobb is in the right track in critiquing the computational model of the brain and the mind. His materialism prevents him from following his genuine insights to their logical conclusion: Human beings have souls with material and immaterial powers, and some of the material powers are caused by the brain.

Cobb is shortly publishing a book, The Idea of the Brain, of which his essay in The Guardian is an edited excerpt. It looks like a worthwhile read. He understands the limitations that plague the philosophical basis of modern neuroscience but he needs to think more clearly about the source of the metaphysical errors that plague neuroscience, which is materialism.

See also: Did consciousness evolve? A Darwinist responds. Jerry Coyne argues that consciousness is a mere byproduct of useful traits that are naturally selected. But wait (Michael Egnor)

Further reading on the brain as a computer (or probably not)

We will never solve the brain. A science historian offers a look at some of the difficulties we face in understanding the brain. In a forthcoming book, science historian Matthew Cobb suggests that we may need to be content with different explanations for different brain parts. And that the image of the brain as a computer is definitely on the way out.

Why the brain is not at all like a computer. Seeing the brain as a computer is an easy misconception rather than an informative image, says neuroscientist Yuri Danilov.

Brains are not billions of little computers. Despite the hype. Also, life forms are not machines and neurons are not neural networks.

The brain is not a meat computer. Dramatic recoveries from brain injury highlight the difference. (Michael Egnor)

The brain exceeds the most powerful computers in efficiency.

and

Some people think and speak with only half a brain. A new study sheds light on how they do it.

Originally posted here:
The Mind Is the Opposite of a Computer - Walter Bradley Center for Natural and Artificial Intelligence