All posts by medical

Prabal Gurung on Hope, Unity, and Innovation Amidst the Coronavirus Crisis – Vogue

The office is closed. All of the teams [at Prabal Gurung] are working from home, but staying in close communications. We are taking the safety of our team very seriously. The coronavirus is impacting us all, and its really got me thinking about how the industry does business, and how I want my brand to grow from this experience.

Around a year ago, I started to take a look at my business and see how I could make changes to operate at the most efficient level. Now, our spring and resort collections are 100% shipped and have been doing really well. As a matter of fact, this is the first time in our brand history where weve had three gowns with 100% sell-through. That said, the industry will continue to be rocked by the coronavirus, and to survive this particular moment we really, really need to look at how we do business. What needs to happen right now is the retailers, the designers, the vendorseveryone needs to work together in finding pragmatic solutions. How do we come together? This situation will not be fixed by a sale.

I have a board at home where Ive outlined immediate issues, a middle section, and long-term problems. I then have a space for potential solutions. In these challenging times I think we must slow down, and think about innovation. How do we become more inventive and, for lack of better words, how do we hustle? I think about what consumers will want to wear once this is over. Are they going to be buying exuberant pieces, or are they going to be more understated and practical? Ive always believed in clothes to bring joy, but what does joy look like in this particular moment? These are the questions that are on my board and on my mind. I think about how we can evolve in this situation, and what the immediate needs of society and culture are, and how we can fill them.

Tackling an issue of this magnitude requires unity. We have to reach across departmental and industry lines to pull in help from a global braintrust of brilliant creatives and business leaders. Ive been doing live chats on Instagram with Kelly Rowland, Tina Craig from The Bag Snob, and Phillip Lim. We discuss the things that are really troubling us, whether it be about our businesses, or things that are more personal, emotional, or spiritual.

I find myself particularly consumed by the human issues surrounding the coronavirus outbreak. During crisis and stressful times, we get to see human behavior in its truest form: greed, compassion, altruism, empathy, fear, strength, and xenophobia. All the positive and negative sides come out, and they are two sides of the same coin. I am so distraught over the hateful acts of racism and xenophobia I have seen towards Asians during this time. From people feeding into racist tropes on Instagram, to the leader of this country, President Trump, dubbing this the Chinese virus I am disheartened to see these instances of fear and ignorance winning over compassion.

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Prabal Gurung on Hope, Unity, and Innovation Amidst the Coronavirus Crisis - Vogue

Contrary to How it Seems, Humans Band Together During and After Disasters – tor.com

In November 2018, the largest and most deadly wildfire in California history destroyed entire towns and displaced thousands of people. In 2017, Hurricane Harvey drowned southeast Texas under punishing, endless rain. And in early 2020, Australia continues to grapple with bushfires that threatened to engulf the continent over its summer. Apocalyptic-scale disasters happen every day (and more often now, as climate change intensifies weather patterns all over the world.) Apocalyptic disaster isnt always the weather, either: its human-made, by war or by industrial accident; by system failure or simple individual error. Or its biological: the flu of 1918, the Ebola outbreaks in 2014, COVID-19 now.

In science fiction, apocalypse and what comes after is an enduring theme. Whether its pandemic (like in Emily St. John Mandels Station Eleven and Stephen Kings The Stand), nuclear (such as Theodore Sturgeons short story Thunder and Roses or the 1984 BBC drama Threads), or environmental (Octavia Butlers Parable of the Sower, Kim Stanley Robinsons New York 2140, and a slew of brilliant short fiction, including Tobias Buckells A World to Die For (Clarkesworld 2018) and Nnedi Okorafors Spider the Artist (Lightspeed 2011), disaster, apocalypse, and destruction fascinate the genre. If science fiction is, as sometimes described, a literature of ideas, then apocalyptic science fiction is the literature of how ideas go wrongan exploration of all of our bad possible futures, and what might happen after.

Most of apocalyptic literature focuses on all the terrible ways that society goes wrong after a society-disrupting disaster, though. This is especially prevalent in television and filmthink of The Walking Dead or 28 Days Later where, while the zombies might be the initial threat, most of the horrible violence is done by surviving humans to one another. This kind of focus on antisocial behaviorin fact, the belief that after a disaster humans will revert to some sort of base state of naturereflects very common myths that exist throughout Western culture. We think that disaster situations cause panic, looting, assaults, the breakdown of social structuresand we make policy decisions based on that belief, assuming that crime rises during a crisis and that anti-crime enforcement is needed along with humanitarian aid.

But absolutely none of this is true.

The myth that panic, looting, and antisocial behavior increases during the apocalypse (or apocalyptic-like scenarios) is in fact a mythand has been solidly disproved by multiple scientific studies. The National Earthquake Hazards Reduction Program, a research group within the United States Federal Emergency Management Administration (FEMA), has produced research that shows over and over again that disaster victims are assisted first by others in the immediate vicinity and surrounding area and only later by official public safety personnel [] The spontaneous provision of assistance is facilitated by the fact that when crises occur, they take place in the context of ongoing community life and daily routinesthat is, they affect not isolated individuals but rather people who are embedded in networks of social relationships. (Facing Hazards and Disasters: Understanding Human Dimensions, National Academy of Sciences, 2006). Humans do not, under the pressure of an emergency, socially collapse. Rather, they seem to display higher levels of social cohesion, despite what media or government agents might expector portray on TV. Humans, after the apocalypse, band together in collectives to help one anotherand they do this spontaneously. Disaster response workers call it spontaneous prosocial helping behavior, and it saves lives.

Spontaneous mobilization to help during and immediately after an apocalyptic shock has a lot of forms. Sometimes its community-sourced rescue missions, like the volunteer boat rescue group who call themselves the Cajun Navy. During Hurricane Harvey, the Cajun Navyplus a lot of volunteer dispatchers, some thousands of miles away from the hurricaneused the walkie-talkie app Zello to crowdsource locations of people trapped by rising water and send rescuers to them. Sometimes it is the volunteering of special skills. In the aftermath of the 2017 Mexico City earthquake, Mexican seismologistswho just happened to be in town for a major conference on the last disastrous Mexico City earthquake!spent the next two weeks volunteering to inspect buildings for structural damage. And sometimes it is community-originated aidthis New Yorker article about 2018s prairie fires in Oklahoma focuses on the huge amount of post-disaster help which flowed in from all around the affected areas, often from people who had very little to spare themselves. In that article, the journalist Ian Frazier writes of the Oklahomans:

Trucks from Iowa and Michigan arrived with donated fenceposts, corner posts, and wire. Volunteer crews slept in the Ashland High School gymnasium and worked ten-hour days on fence lines. Kids from a college in Oregon spent their spring break pitching in. Cajun chefs from Louisiana arrived with food and mobile kitchens and served free meals. Another cook brought his own chuck wagon. Local residents old friends, retired folks with extra time, came in motor homes and lived in them while helping to rebuild. Donors sent so much bottled water it would have been enough to put out the fire all by itself, people said. A young man from Ohio raised four thousand dollars in cash and drove out and gave it to the Ashland Volunteer Fire Department, according to the Clark County Gazette. The young man said that God had told him to; the fireman who accepted the donation said that four thousand was exactly what it was going to cost to repair the transmission of a truck that had failed in the fire, and both he and the young man cried.

These behaviors match the roles and responsibilities that members of a society display before the apocalyptic disaster. Ex-military volunteers reassemble in groups resembling military organizations; women in more patriarchal societies gravitate towards logistics and medical jobs while men end up taking more physical risks; firefighters travel to fight fires far away from their homes. The chef Jos Andrs served more than three million meals over three months after Hurricane Maria devastated Puerto Rico. Humans all over the world display this behavior after disasters. They display it consistently, no matter what kind of disaster is happening or what culture they come from.

What really happens after an apocalypse? Society works better than it ever had, for a brief time.

The writer Rebecca Solnit wrote an entire book about this phenomenon, and she called it A Paradise Built in Hell. She points out that it is really the fear on the part of powerful people that powerless people will react to trauma with irrational violence that is preventing us from seeing how apocalypse really shapes our societies. Solnit calls this elite panic, and contrasts it with the idea of civic temperthe utopian potential of meaningful community.

Apocalyptic science fiction tells us so much about how the future is going to hurtor could. But it can also explore how the future will be full of spontaneous helping; societies that bloom for a night, a few weeks, a month, to repair what has been broken. The human capacity to give aid and succor seems to be universal, and triggered quite specifically by the disruption and horror of disaster. Science fiction might let us see that utopian potential more clearly, and imagine how we might help each other in ways we never knew we were capable of.

This article was originally published in November 2018. You can find the original version here.

Arkady Martine writes speculative fiction when she isnt writing Byzantine history. She is overly fond of borders, rhetoric, and liminal spaces. Her novel A Memory Called Empire is available from Tor Books. Find her on Twitter as @ArkadyMartine.

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Contrary to How it Seems, Humans Band Together During and After Disasters - tor.com

Why Digital Transformation Is A Necessity For All SMBs – Forbes

Digital transformation happens to be one of the most talked-about terms among small and midsize businesses (SMBs) today. According to a Google-KPMG report, digitally engaged SMBs boost profits up to twice as fast compared to their offline counterparts. The induction of digital platforms allows SMBs to uncover new market opportunities, driving overall growth.

Figures Worth Noticing

The economic value of digital transformation is expected to reach $100 trillion by 2025.

Twenty-one percent of organizations believe their digital transformation efforts are complete.

According to Gartner,"Eighty-seven percent of senior business leaders say digitalization is a company priority, and 79% of corporate strategists say it is reinventing their business creating new revenue streams in new ways."

Nearly71% of leadersfirmly believe that the role of the workforce crucial in implementing digital transformation.

Digital Transformation

Those numbers should be convincing enough for SMBs to integrate technologies within their business workforce if they haven't done so already. However, of all the means available to disrupt almost any industry, data is at the forefront.

From analytics to AI, data never fails to amaze the scientists working on uncovering the potential of digital transformation. According toGartner, 90% of the organizational strategies will be based on relevant information by 2022, which means that data will have a value higher than ever.

However, the data received is raw, and to put this data to use, the data is first analyzed, segmented and studied. It helps business leaders to have a better view of market trends, customer expectations and future outcomes. Needless to state that the present face of business is highly competitive, and SMBs must take a step forward and take up measures that own the potential to better their overall operational efficiency.

Why Do SMBs Need Digital Transformation? (Traditional Vs. Digital)

Data has been a part of every industry since the beginning, and so it was just a matter of time before business professionals would eventually contemplate utilizing this data to enhance their organizational efficiency.

But how or why?

The top-scale organizations have already invested in digital technologies to better their everyday business functions and gain a cutting edge in the competitive market.

From robotics to automation, machine learning to predictive analytics, modern-day organizations are driven digitally, and it's time that SMBs get over their traditional form of operations.

The traditional form of business relied on word of mouth to promote brand visibility and managing multiple spreadsheets manually instead of using seamlessly integrated cloud solutions. However, the digital business economy mandates the usage of online marketing methods to enhance a brands value and connected cloud-based solutions to improve operational efficiencies.

And to top it all off, the traditional form of business focused on prioritizing profits, but the digital marketplace is focused on customers above all.

Getting Started

If you own an SMB and are looking to get started with digital transformation, start by discussing what digital transformation is with your team and how it will affect your business. A few questions to consider:

What are the different aspects of your business that lag behind your competitors?

Which elements in the existing business plan need to be replaced or technologically upgraded?

What operations consume a lot of time and can be automated?

Implementation

Once you have analyzed and examined the different areas that need to be improved, move ahead with the adoption of trends that promote digital transformation within your organization:

Digital presence with end user in mind: To be competitive, having a digital presence is a must. A website is not enough, but a thoughtful website that is built with your end users and customers in mind and helps push them deeper into your sales funnel is a must for your business, along with a presence on other digital platforms your customers regularly visit.Along with having a website,you also need to make sure that your website is optimized for mobile devices. As perGoogles 200 ranking factors, mobile-friendliness is one of the significant things to take into consideration, and there are now 3.5 billion smartphone users.

Predictive strategies: Whereas the traditional form of business worked on guesswork, the digital era relies on data to analyze and study human behavior. Based on the previous user interaction, companies drive data and then use this data to analyze how a user would react in a particular situation.

Omnichannel presence and interconnected systems: Digitization has a ubiquitous presence, and there is now a whole generation of users who are not platform-specific. So, in order to reach out to most of them, you need to work on creating an omnichannel presence to promote your products and services. You also need a robust integration strategy for all these channels to get a 360-view of operations.

Future

This is just the start. The gamut of digital transformation is huge, and there is more to this than meets the eye. According to research,85% of decision-makers believe that they need to integrate digital methods within their operations in two years or less.

With such huge investments, the future of digital transformation will see technology at the core of every business operation and customers as king. However, there will be dramatic scarcity in the available skills and resources, and top leaders need to focus on that and work toward curbing its impact.

What you can do is stop anticipating and start working. Are you ready for change?

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Why Digital Transformation Is A Necessity For All SMBs - Forbes

How light, other sensory pollution impacts animal… – ScienceBlog.com

A new paper including research from a Utah State University scientist provides a framework for understanding how light and noise pollution affects wildlife. The framework is the product of an effort among worldwide experts in ecology and physiology and reveals the presence of sensory danger zones, or areas where sensory pollutants influences animal activity. The study is published in the journalNature Ecology and Evolution. The paper is a collaborative work with principal investigator Neil Carter, assistant professor at the School for Environment and Sustainability. From a conservation biology point of view, we dont know how to mitigate the effects of sensory pollution if we dont know what the pathway of harm is, said Carter.

Although these results have consequences for imperiled species of conservation concern, they also suggest ways by which we may use light and sound for managing urban wildlife, mitigating wildlife-vehicle collisions, or preventing agricultural damage. said David Stoner, a research assistant professor in the Quinney College of Natural Resources at USU.

In their study, the authors give an example of New York Citys annual 9/11 memorial tribute. The tribute coincides with birds annual migration from northern regions to wintering grounds in Latin America. Because birds use celestial cues during their migration, the 44 spotlights that form two pillars of light can attract up to 15,000 birds in a single night.

(The birds) will fly in circles inside the beams until morning, often dying from exhaustion and collisions with artificially lit structures, according to Carter and co-lead authors Davide Dominoni, a researcher of biodiversity, animal health and comparative medicine at the University of Glasgow; and Wouter Halfwerk, assistant professor in the Department of Ecological Science at VU Amsterdam University.

Both light pollution and traffic noise can mimic natural stimuli. For example, artificial lights cover the glow of the moon, preventing birds or insects from detecting it, or traffic noise can mask the audio spectral frequency of bird song, the researchers say.

These pollutants can also redirect an animals attention away from its task: a cougar hunting deer can be distracted by headlights or road noise.

If we understand the mechanism at play, perhaps we can devise specific interventions and solutions to adopt to minimize the effect of anthropogenic impacts, Dominoni said. For instance, light has a lot of properties. By changing some of these properties, we might very well minimize the impact light pollution has on wildlife.

Night lighting and anthropogenic sound are not localized to certain habitats and certain countries. Its a global phenomenon, he said. Clarifying these mechanisms can help develop solutions to biodiversity loss and anthropogenic impacts worldwide.

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How light, other sensory pollution impacts animal... - ScienceBlog.com

Student Coronavirus Tracking Website Tops Nearly 1.4 Million Views From 193 Countries – UVA Today

Find the latest information on the Universitys response to the coronavirus here.

TrackCorona, a COVID-19 tracking website developed by two University of Virginia students, James Yun and Soukarya Ghosh, and friends at Virginia Tech and Stanford University, is proving to be a valuable public service for anyone who wants to know more about the development of the pandemic. The website went live in early February with only a smattering of clicks by people who already knew about the site. Now, more than 300,000 people in 193 countries have visited the website about 1.4 million times.Were averaging more than 40,000 users per day for the last week, with a record 50,000 users on March 12, said Ghosh, a third-year computer science and mathematics major who helped lead development of the site. Were on trajectory for 50,000 more on the 16th.

TrackCorona provides up-to-date information about the spread of the virus, including infection and mortality rates, recovery rates and locations by country, with links to the latest news and accurate information. The student team uses data from the World Health Organization, the U.S. Center for Disease Control and other infectious disease information sources. The data is made visual with a near-real-time map that displays the growth of the pandemic.

The students have consulted with several UVA faculty members in the development of their site, seeking to optimize the quality of the data and information.

Dr. Christopher Holstege, director of UVA Student Health, is serving as a contact to the students for medical questions. Wladek Minor, a professor of molecular physiology and biology physics, has offered the students an opportunity to co-write a research paper analyzing the spread of COVID-19. David Leblang, a professor of politics and public policy, has proposed a research role for the students in a study on the cascading effects of the pandemic. And Bryan Lewis, an epidemiologist at UVAs Biocomplexity Institute, has offered advice and a summer internship.

Fellow students also have proposed ideas to Yun and Ghosh and suggested sources for reliable information about the virus and its spread.

Its not every day that you get to work on something with this large of an audience and potentially save lives, Yun, a fourth-year computer science major, said. Being part of this startup-like journey has taught me how to manage exponential user growth, seek funding and deal with the occasional cyberattack.

This summer Yun will begin work as a software engineer at Capital One, where he says he will use the skills hes picked up along the way, in his classes and through development of the website.

TrackCorona is a visually compelling website, well designed, user-friendly, full of relevant information, epidemiologist Bryan Lewis said. The team has done a nice job of creating this, especially considering their busy schedules as students. It is a form of citizen science that is valuable to the community.

TrackCorona is a nominee for the Social Good of the Year award by the Charlottesville Business Innovation Council; as well as for Innovator of the Year; and Student Entrepreneurs of the Year awards. The students are seeking funding to keep the site operating, as costs for cloud computing and other resources are running about $350 per day.

Doing this work has been very fulfilling, Ghosh said. I already had a strong urge to do work that would benefit the welfare of the public, and this experience has further engrained and confirmed that for me. I hope to continue to do similar work in my career after UVA, using the skills I have learned here to make an even bigger impact.

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Student Coronavirus Tracking Website Tops Nearly 1.4 Million Views From 193 Countries - UVA Today

Coronavirus: Why an Outright Ban of Wildlife Trade Could Be Counterproductive – The National Interest

The wildlife trade has long been closely linked to disease outbreaks. It has been implicated in the SARS epidemic of 2002, Ebola in 2013 and now in the COVID-19 coronavirus.

In response to the COVID-19 outbreak, China has tentatively banned the farming of many wildlife species. The move has been celebrated by many in the international community.

But our work in Asia over the past ten years tells a different story. Banning legitimate snake farms might prove counterproductive to disease suppression.

Though snakes were early suspects as the source of the Wuhan coronavirus, reptiles have never been linked to any of the World Health Organisations top ten infectious diseases which pose the greatest threat of epidemics.

Snakes are different

One reason is straightforward. Snakes are cold-blooded (more correctly ectothermic) and have a very different physiology to humans. Viruses co-evolve highly specialised relationships with their hosts and are often species-specific.

Occasionally, a chance mutation might allow a virus to infect another species, but the more different the new and old hosts are to each other, the less likely that is.

Compared with transmission between mammals, or even from birds to mammals, the probability of a virus crossing from a cold-blooded reptile to a warm-blooded human is remote.

In parts of Asia where H5N1-type viral outbreaks such as bird and swine flu are now endemic, hundreds of snake farmers rely on waste protein such as pork and poultry by-products as feed.

Disease outbreaks regularly wreak havoc with conventional livestock industries but never, to our knowledge, with snake farming.

In this context, reptiles represent a natural biological barrier to viral diseases.

They enable farmers to build financial resilience through diversity, dampening the many risks associated with livestock monocultures.

And the benefits dont end there.

Theyre tailor-made for sustainability

Commercial snake farming has developed rapidly in China. The first experimental farms were set up in 2007; by 2019 the industry was producing large-scale high-quality protein.

Some snakes have highly desirable agricultural traits including rapid growth, early maturation and rapid reproduction. They are comparatively simple cognitively, and do not suffer the complex behavioural stresses seen in many caged birds and mammals.

Many are semi-arboreal, spending time in trees, allowing farms to maximise available space.

They do require a high-protein diet but, since their cold-blooded metabolic demands are very low (less than 10% of similar-sized mammals), food can be more directly channelled to growth.

The energy efficiency is achieved mainly by employing solar energy (e.g., basking) to drive metabolic processes, and by powerful digestive systems capable of breaking down even bone.

It means they produce low volumes of biological waste and greenhouse gases, and require minimal fresh water.

Chinese snake farms rely on two principal sources of feed inputs: waste protein from agricultural food chains, and natural prey such as harvested rodents.

This means they both recycle agricultural waste and control economically important rodent pests.

Their cold-blooded physiology allows them to survive for considerable time without food and water far longer than similarly-sized warm blooded animals.

This allows farmers to effectively exploit seasonal abundances during times of plenty, and downscale inputs during times of famine.

Snake farming therefore provides a resilient livelihood in the face of economic volatility and the extremes of Climate Change.

It would be a shame if concern about coronavirus snuffed out an industry that is unlikely to be the problem, but could very well be a solution.

Daniel Natusch, Honorary Research Fellow, Macquarie University; Graham Alexander, Professor of Herpetology, Environmental Physiology and Physiology, Ecology and Evolution, University of the Witwatersrand; Ngo Van Tri, Conservation biologist, Institute of Tropical Biology, and Patrick Aust, Research Associate, Department of Zoology, University of Oxford

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Image: Reuters

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Coronavirus: Why an Outright Ban of Wildlife Trade Could Be Counterproductive - The National Interest

Nitric Oxide Industry Outlook to 2028 – Pathways, Physiology, Disease, Pharmacology, Therapeutic Applications, Drugs, Therapy Markets, Companies – P&T…

DUBLIN, March 13, 2020 /PRNewswire/ -- The "Nitric Oxide - Therapeutics, Markets and Companies" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering.

Share of drugs where NO is involved in the mechanism of action is analyzed in the worldwide pharmaceutical market for 2018 and is projected to 2023 and 2028 as new drugs with NO-based mechanisms are introduced into the market. Various strategies for developing such drugs are discussed.

Several companies have a product or products involving NO and free radicals. The report includes profiles of 35 companies involved in this area of which 9 have a significant interest in NO-based therapeutics. Other players are pharmaceutical and biotechnology companies as well as suppliers of products for NO research. Unfulfilled needs in the development of NO-based therapeutics are identified. Important 18 collaborations in this area are tabulated.

There are numerous publications relevant to NO. Selected 500 references are included in the bibliography. The text is supplemented with 26 tables and 30 figures. It is concluded that the future prospects for NO-based therapies are bright and fit in with biotechnology-based approaches to modern drug discovery and development. It is anticipated that some of these products will help in meeting the unfulfilled needs in human therapeutics.

The report contains information on the following:

The report describes the latest concepts of the role of nitric oxide (NO) in health and disease as a basis for therapeutics and development of new drugs. Major segments of the market for nitric oxide-based drugs are described as well as the companies involved in developing them.

Nitric oxide (NO) can generate free radicals as well as scavenge them. It also functions as a signaling molecule and has an important role in the pathogenesis of several diseases. A major focus is delivery of NO by various technologies. Another approach is modulation of nitric oxide synthase (NOS), which converts L-arginine to NO. NOS can be stimulated as well as inhibited by pharmacological and gene therapy approaches.

Important therapeutic areas for NO-based therapies are inflammatory disorders, cardiovascular diseases, erectile dysfunction, inflammation, pain and neuroprotection. The first therapeutic use of NO was by inhaltion for acute respiratory distress syndrome (ARDS). NO-donors, NO-mimics and NOS modulators are described and compared along with developmental status. NO-related mechanisms of action in existing drugs are identified.

Various pharmacological approaches are described along with their therapeutic relevance. Various approaches are compared using SWOT (Strengths, Weaknesses, Opportunities, Threats) analysis. NO-based therapies are compared with conventional approaches and opportunities for combination with modern biotechnology approaches are described.

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Coronavirus: sequencing the DNA of patients screened for coronavirus might save lives – The Conversation UK

Scientists should start sequencing the genomes of coronavirus patients. We should look for DNA differences between patients who are severely affected and those with mild symptoms. This could allow us to predict who else would be vulnerable and advise them to take precautions. We may be able to use this knowledge against the coronavirus epidemic before a vaccine is widely available.

In particular, it would be valuable to know if key DNA variations are shared by those rare people who are young and appeared to be healthy but developed severe symptoms from the coronavirus. We might then be able to predict which doctors and nurses are most at risk and remove them from the front line.

Of course, we dont yet know if accurate predictions will be possible. We dont even know if someones chances of severe symptoms from the coronavirus are affected by their genes. We could, however, answer these questions relatively cheaply and rapidly by using commonplace DNA sequencing technology.

Read more: Will warmer weather stop the spread of coronavirus?

We would need to sequence the whole genomes of coronavirus victims who need intensive care and compare them with the genomes of people who have only mild symptoms. With only a few thousand genomes from each category, we could quickly find out if there is mileage in this approach.

It may be that just one or two genes are involved. Perhaps broken genes involved in the immune system or lung cell surfaces. If so, we could quickly discover them using a method called genome-wide association study. If just a couple of broken genes make all the difference, a genetic test for coronavirus susceptibility could be simple to make, cheap and accurate.

It may be that there are thousands of genes involved. Perhaps a complex mix of genes involved in lung physiology, upper respiratory tract shape, and many other things we have never even thought of. If this is the case, working out exactly what is going on could take decades. But we need answers within weeks or months.

Here we can draw on an unexpected source of inspiration: we can use a method called genomic prediction, which has been used successfully for decades by plant and animal breeders, but is seldom used in medicine. It enables the prediction of complex traits from whole-genome sequences, even when we do not understand what any of the genes are doing.

With this approach, we do not need to spend several years working out what exactly is going on. We can construct a score from a persons whole-genome sequence that predicts their susceptibility. These scores could be obtained at the cost of (we estimate) only a few hundred pounds per person.

We took a genomic prediction approach last year for ash trees, which are dying from a fungal epidemic. By comparing the genomes of healthy versus dying trees, we discovered over 3,000 points in their genomes that contribute to susceptibility. Some of these were in genes that had known functions in host defences, but for many others, we had no idea what they did. Yet we did not need that knowledge to predict the susceptibility of other ash trees with a useful level of accuracy.

Read more: Ash dieback: one of the worst tree disease epidemics could kill 95% of UKs ash trees

We should do similar studies on humans and coronavirus. Of course, there would be more complex issues of privacy and consent than we had to deal with for ash trees. But tens of thousands of human genomes have already been sequenced around the world, so the issues around consent have been well explored. For some coronavirus patients, their genome will already be in a database.

Should we find that we can make accurate predictions, the moral and psychological challenges would be severe. Where should tests be deployed? Will people respond appropriately if they are predicted to be at risk (or not)? How would it affect health insurance? But difficult challenges are faced in every decision that we have to make in our battle against the virus.

Read more: Homemade hand sanitiser recipes that could help protect against coronavirus

Research on the genetic basis of susceptibility to the coronavirus could be done quickly and without diverting resources from research on treatments and vaccines. It might show that predictions are impossible. It might show that accurate predictions can be made. We dont know. But we need to find out. If it worked, it might protect thousands of lives before a vaccine is widely available.

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Coronavirus: sequencing the DNA of patients screened for coronavirus might save lives - The Conversation UK

High Content Screening Market Trends and Growth Factors Analysis to 2025 – BioSpace

High-content screening (HCS) refers to a technique used in biological research and drug discovery to discover substances such as peptides, small molecules, or RNAi that change the phenotype of a cell as desired. Phenotypic changes may include increase or decrease in the production of cellular components such as protein and/or alterations in the visual appearance of the cell.

High-content screening merges the molecular tools of cell biology with automated robotic handling, high-resolution microscopy, and automated analysis.

Global High Content Screening Market: Key Trends

The high-content screening market is driven by increasing funding and venture capital investments for cellular research, technological developments in HCS solutions, and cost containment in pharma R&D. However, factors such as high cost of HCS equipment and lack of expert and skilled personnel for operation of equipment are posing a challenge to the markets growth. In addition, inadequate research infrastructure and insufficient funding for R&D in emerging nations is limiting this markets growth.

The high-content screening market is segmented in terms of product, application, end user, and region. In terms of product, instruments, software, consumables, services, and accessories are the segments of this market. The segment of instrument held the leading share of the market in the recent past. The cell imaging and analysis segment held the leading share of the instrument segment of the HCS market. The instrument segment holds the leading share due to advances in instrumentation and automation techniques.

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On the basis of application, target identification and validation, toxicity studies, primary and secondary screening, compound profiling, and others are the segments of the HCS market. The segment of primary and secondary screening dominated the market in the recent past. The dominance of this segment is due to its large-scale usage in qualitative assays for lead specificity, evaluation of bioavailability, and exclusion of compounds with unintended modes of action.

In terms of end user, the HCS market is segmented into academic and government institutes, pharmaceutical and biotechnology companies, and contract research organizations. The segment of pharmaceutical and biotechnology companies held the leading share of the global HCS market in the recent past. The dominance of this segment is owing to the extensive usage of HCS in preclinical and clinical studies in the biotechnology and pharmaceutical industries.

Global High Content Screening Market: Market Potential

Beyond its conventional application in biological resaerch, high-content screening is being used in studying fat accumulation in cells. Researchers at the Department of Environmental Science at University of Georgia College of Public Health carried out studies to determine how exposure to phthalates in the form of nail polish or soap is related to the amount of fat stored in our bodies.

High-content screening employs image processing algorithms and computer machine language to measure multiple parameters objectively in no time.

Global High Content Screening Market: Regional Outlook

North America is the leading market for high-content screening trailed by the regions of Europe, Asia Pacific, Latin America, and the Middle East and Africa. High research and development expenditures, government support for research initiatives, and the presence of leading lifescience market players are attributed to the dominance of North America high content screening market.

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Global High Content Screening Market: Competitive Landscape

The key players in the global high content screening market include GE Healthcare, PerkinElmer Inc., Becton, Dickinson and Company, Danaher Corporation, and Thermo Fisher Scientific Inc. Some other players in the market include BioTek Instruments Inc., Tecan Group Ltd., Merck Millipore, Bio-rad Laboratories Inc, and Yokogawa Electric Corporation.

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Originally posted here:
High Content Screening Market Trends and Growth Factors Analysis to 2025 - BioSpace

There’s mixed evidence on whether people with Covid-19 should avoid ibuprofen – Full Fact

#COVID-19 The taking of anti-inflammatories [ibuprofen, cortisone] could be a factor in aggravating the infection. In case of fever, take paracetamol. If you are already taking anti-inflammatory drugs, ask your doctors advice.

Olivier Vran, 14 March 2020 [in French]

French health minister Olivier Vran warned on Twitter that people suffering from Covid-19 should avoid taking anti-inflammatories like ibuprofen or cortisone. The comments made by Mr Vran, who is a qualified doctor and neurologist, have been widely reported in the British press.

Some health professionals have warned that paracetamol is preferable to ibuprofen, as it is less likely to cause side effects in people with underlying health issues, who are also more susceptible to Covid-19. (Cortisone is not commonly used in the UK to relieve symptoms like fever.)

Until March 16, when this article was first published, NHS advice for people self-isolating because of the new coronavirus recommended drinking lots of water and taking everyday painkillers, such as paracetamol and ibuprofen, to help with your symptoms.

However, the NHS has now changed this guidance. Although it says there is currently no strong evidence that ibuprofen can make coronavirus (Covid-19) worse, it recommends using paracetamol to treat the symptoms until we have more information. The exception to this is if a doctor has told you not to use paracetamol.

It adds that, if you are taking ibuprofen or other non-steroidal anti-inflammatories (NSAID) on the advice of a doctor, you should not stop doing so without checking first.

Dr Charlotte Warren-Gash, associate professor of epidemiology at the London School of Hygiene and Tropical Medicine, said that NSAIDs like ibuprofen should be prescribed with caution for people who have underlying health conditions.

For Covid-19, research is needed into the effects of specific NSAIDs among people with different underlying health conditions, which takes into account the severity of infection. In the meantime, for treating symptoms such as fever and sore throat, it seems sensible to stick to paracetamol as first choice.

Dr Rupert Beale, group leader in cell biology of infection at The Francis Crick Institute, said: There is good reason to avoid ibuprofen as it may exacerbate acute kidney injury brought on by any severe illness, including severe Covid-19 disease.

There isnt yet any widely accepted additional reason to avoid it for Covid-19.

Professor Paul Little, professor of primary care research at the University of Southampton, said there was sizeable literature from case control studies in several countries that the complications of respiratory infections - whether respiratory, septic or cardiovascular complications - can be more common when NSAIDs are used.

He added that using paracetamol was less likely to result in complications.

On 16 March, Public Health England confirmed there is not enough information on ibuprofen use and Covid-19 to advise people to stop using ibuprofen, and said there is no published scientific evidence that ibuprofen increases the risk of catching Covid-19 or makes the illness worse.

Full Fact contacted PHE for more information about the decision to change the NHS guidance the next day, but has not yet received a response.

Asked by the governments health and science committee about the concerns over taking ibuprofen on 17 March, government chief scientific adviser Sir Patrick Vallance said the warnings may or may not be right, I dont know. But the sensible thing to do I think would be to say well dont take it at the moment. Take something else, paracetamol or something.

If taking any painkillers, you should always follow the instructions on the label and make sure you do not exceed the stated dose.

Patients prescribed NSAIDs for long-term health problems should take them as directed by a healthcare professional.

Update 17 March 2020

This piece was updated following changes to the NHS guidance for people with Covid-19 symptoms.

Update 17 March 2020

This piece was updated following changes to the NHS guidance for people with Covid-19 symptoms.

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There's mixed evidence on whether people with Covid-19 should avoid ibuprofen - Full Fact