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‘Devs’ Episode 4 will see Lily fear for her life as Kenton drives her to psychiatric appointment – MEAWW

Alex Garlands science fiction miniseries Dev is at a critical juncture. The show follows the story of a young software engineer, Lily Chan (Sonoya Mizuno), investigating the secretive development division of her employer which she believes is behind the murder of her boyfriend Sergei (Karl Glusman). In the first three episodes, the series built the premise.

Amaya, run by Forest (Nick Offerman), an eccentric-looking man who believes in causal determinism, has created a technology that would paradoxically both change the world, and not change it at all.

Sergei, who was put in the titular Devs team, may perhaps have been a Russian spy committing industrial espionage. When caught, the companys head of security Kenton (Zach Grenier) murders him on Forests orders and frames it as suicide.

Lily, who was initially in shock, comes to realize this death couldnt have been suicide. With her ex-boyfriend Jamie (Jin Ha), she examines the footage where Sergei allegedly self-immolates. Jamie, however, notices a critical flaw in the video and they realize it was a doctored video.

As per IMDb, the synopsis for episode four reads: After Lily's behavior at Amaya, Kenton forces her to see a psychiatrist. Meanwhile, the Devs team disagree over the ethics of their invention, and Forest asserts his commitment to the project.

Lilys behavior refers to her pretending she was a paranoid schizophrenic, who had psychotic episodes in the past. She even stood at the ledge of Kentons office, pretending to be suicidal. That was, of course, a ruse to divert Kentons attention while her friend Jen (Linnea Berthelsen) steals a file from his system.

In the promo for Episode 4, we see Forest tell Katie (Alison Pill) that he was scared. When asked about what, he says, Us".

This might very well be about the nature of work being done at the Devs division: developing a method to predict human behavior through quantum computing. The technology in the previous episode, it successfully (through the examination of behavioral patterns) visualizes American playwright Arthur Miller and model Marilyn Monroe (they were married for a while) having sex has extraordinary ramifications. In one way, it can change everything about the world.

To be able to predict human behavior is to play God. Forest, despite his absolute belief in fatalism, has every right to fear the awesome powers of this technology.

At the same time, we see Lily saying, Theyre gonna kill me, likely referring to Forest and Kenton. As the latter takes her (or rather forces her) to visit a psychiatrist, and even proceeds to drive her there, Lily screams, Stop the car. Perhaps, she is afraid that the trip to the shrink is just a ruse to get her isolated, and consequently murder her.

The promo ends with Lily telling Jamie, I stopped seeing them as a tech company. I see them as the Mob. For all that Lily knows right now, her view of Amaya and its leadership is not far off the mark.

Hopefully, Episode 4 will shed more light on the powers of the Amaya technology and also on what Lily plans to do next, now that she knows Sergei did not commit suicide and that the companys narrative was decidedly a false one.

Devs drops on FX on Hulu, every Thursday at 12 am.

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'Devs' Episode 4 will see Lily fear for her life as Kenton drives her to psychiatric appointment - MEAWW

Connecting with NC Cooperative Extension – Asheboro Courier Tribune

What is NC Cooperative Extension?

We are more than cows and corn.

NC Cooperative Extension is Randolphs Countys link to the two land-grant universities in North Carolina (NC State and NC A&T). Land-grant universities have three parts to their mission: education, research and extension. NC Cooperative Extension extends research-based knowledge to all North Carolinians, helping them transform science into everyday solutions that improve their lives and grow our state.

Why Cooperative Extension?

Essential to extensions mission to grow the state is our collaboration with the US Department of Agricultures National Institute of Food and Agriculture (USDA-NIFA), NC State University, NC A&T State University and local (county) governments across the state. This strategic partnership and cooperation are why it is called Cooperative Extension.

Statewide, our funding is 14% federal, 36% state, 25% county and 25% other (grants, contracts donations etc). It is truly a cooperative effort to offer our services to North Carolina residents.

History of success: Then and now

In 1909, information was shared through a Boys Corn Club (the beginnings of 4-H) in Ashokie, NC, that adding nutrients to your cornfield by spreading manure could increase the corn yield. A young boy took that information when the average yield was 18 bushels per acre and increased his yield to 196 bushels per acre in two years. NC Cooperative Extension is still researching ways to increase farm productivity as the worlds population increases and with its demand for food.

Currently, agriculture is North Carolinas largest industry, generating $91.8 billion annually while employing roughly 17 percent of the states workforce. Ours is the third most diverse agriculture economy in the country, with more than 80 commercial crops and a large animal agriculture presence.

Another example from the early 1900s happened through Girls Canning Clubs. Young girls were taught food preservation. These girls sold their canned food in the wintertime to earn money. NC Cooperative Extension is still teaching life skills that build capacity in people. n 2019, 47,041 North Carolina consumers increased their knowledge of safe home food handling, preservation or preparation practices.

The Randolph County Center is fully staffed and offers services in all the NC Cooperative Extension program areas.

Adam Lawing is the Livestock Agent. Did you know that Randolph County has more beef cows and goats than any other county in North Carolina? Adam is a great resource for our Randolph County producers.

Blake Szilvay is the Field Crops/Forestry Agent. Blake helps producers identify pests and diseases in crops. He is a licensed drone pilot and uses that technology to help farmers. Blake has also brought forestry programming back to Randolph County to help woodland owners improve management practices. Over 50% of Randolph County is forested, and in 2016, those forested acres provided $4.6 million through harvests.

Ben Grandon is the Horticulture Agent. In 2019, Ben conducted 226 on-site consultations with homeowners. He helps with gardening questions, landscaping and lawn issues, and many more. Ben also leads the Randolph County Master Gardener Volunteer educational group. After Bens training, a Master Gardener Volunteer can provide research-based information about gardening and environmental stewardship to individuals. This years Master Gardener Training Course begins in April.

Jeannie Leonard is the Family and Consumer Sciences Agent. Jeannie can teach food preservation and cooking skills. Recently, her Cooking Under Pressure (Instant Pot) classes have been popular. Her next class is on March 26. Jeannie also works with Randolph County businesses and organizations when they want to offer their employees wellness programs. Jeannie provides training on healthy recipes and cooking tips on location or here at the office.

Allison Walker is the 4-H Agent. Allison is passionate about Randolph County youth. Currently, she is working with 60+ classrooms on the Embryology Project. Allison provides 1 dozen eggs and incubators to each classroom so the teachers can teach the provided embryology curriculum. The second graders learn firsthand about chick development and get to see the chicks emerge from their shells. 4-H is a great youth development program open to all youth, not just farm kids.

Jody Terry is the 4-H Program Assistant. Jody spends many days in afterschool programming. She helps children through character education, healthy lifestyle choices or STEM education. She is gearing up for Bike Safety Week where she helps teach bike safety to the fourth graders. Jody has worked with thousands of children in Randolph County through the years and still remains committed and passionate about 4-H programming for the children.

Contact us by calling 336-318-6000 or visiting https://randolph.ces.ncsu.edu/

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Connecting with NC Cooperative Extension - Asheboro Courier Tribune

Merck Foundation launches programmes in partnership with Namibia First Lady and ministries of health and education – Namibia Economist

Merck Foundation recently announced the First Lady of Namibia as Ambassador of Merck more than a Mother; Merck Foundation Calls for Applications in Namibia for Merck More than a Mother Media Recognition Awards 2020 for English speaking countries to break infertility stigma; Merck Foundation also Calls for Applications for Merck More Than a Mother Fashion Awards from Namibia and rest of Africa.

Merck Foundation, the philanthropic arm of Merck KGaA Germany launched their programmes and conducted their first Merck Foundation Health Media Training in Windhoek, Namibia in partnership with H.E. Monica Geingos, The First Lady of Namibia and the Ambassador of Merck More Than a Mother together with Ministry of Health and Ministry of Education to break the stigma around infertility and build healthcare capacity in Namibia and rest of Africa.

Talking about the Health Media Training program Dr. Rasha Kelej, CEO of Merck Foundation and President of Merck More Than a Mother explained, The Health Media Training program is a part of Merck More than a Mother community awareness Program and is organized for the first time in Namibia for local media representatives and media students to emphasize their critical role to create a culture shift and to be the voice of the voiceless in order to break the stigma around infertile women.

Geingos emphasized, I am very excited to be appointed as ambassador of Merck more than a Mother and to officially launch Merck Foundation programs in our country. Moreover, I am very happy to host this important training program. Media plays an important role is sensitizing our society. It can help in creating awareness about female & male infertility and in breaking the stigma around infertility.

It is important to initiate this important training program as I strongly believe that media has the capacity and ability to break the silence in our communities in a regular and effective basis. Dr. Rasha Kelej added.

The training was addressed by Fertility specialists who are Merck Foundation Alumni and stalwarts of Media.

It provided a great opportunity for the journalists to listen to childless women experience with infertility stigma and to meet the experts and also to network with each other and work as a unit to eradicate the stigma around infertility and its resulted domestic violence in Namibia and rest of Africa.

Merck Foundation together with Namibias First Lady acknowledged the graduates of Merck Foundation programs in different fields of Oncology, Fertility and Embryology, Diabetes and Hypertension. and welcomed to be Merck Foundation Alumni for Namibia.

Merck Foundation in partnership with Ministry of Health of Namibia has provided training for doctors from Namibia to be the first oncologist and fertility specialists in public sector in the country. Moreover, they provided one year on line diploma in cardiovascular preventive medicines and masters program in diabetes management for two doctors. Merck Foundation has committed to continue providing these specialty training to more doctors from different provinces in Namibia.

Merck Foundation recently announced the winners of Merck More Than a Mother Media Recognition Awards 2019. They also announced for Namibian Media, the Call for Application of Merck More Than a Mother Media Recognition Awards 2020 for English speaking countries. The aim of these awards is to emphasize the role of media in enhancing the public engagement and understanding of infertility stigma and the need to change its social perception in African communities.

The applications are invited by media professionals to showcase along the year their work to raise awareness about infertility prevention and breaking infertility stigma.

Read the rest here:
Merck Foundation launches programmes in partnership with Namibia First Lady and ministries of health and education - Namibia Economist

Observational retrospective study of UK national success, risks and costs for 319,105 IVF/ICSI and 30,669 IUI treatment cycles. – DocWire News

This article was originally published here

Observational retrospective study of UK national success, risks and costs for 319,105 IVF/ICSI and 30,669 IUI treatment cycles.

BMJ Open. 2020 Mar 16;10(3):e034566

Authors: Bahadur G, Homburg R, Bosmans JE, Huirne JAF, Hinstridge P, Jayaprakasan K, Racich P, Alam R, Karapanos I, Illahibuccus A, Al-Habib A, Jauniaux E

AbstractOBJECTIVE: To compare success rates, associated risks and cost-effectiveness between intrauterine insemination (IUI) and in vitro fertilisation (IVF).DESIGN: Retrospective observational study.SETTING: The UK from 2012 to 2016.PARTICIPANTS: Data from Human Fertilisation and Embryology Authoritys freedom of information request for 2012-2016 for IVF/ICSI (intracytoplasmic sperm injection)and IUI as practiced in 319 105 IVF/ICSI and 30 669 IUI cycles. Direct-cost calculations for maternal and neonatal expenditure per live birth (LB) was constructed using the cost of multiple birth model, with inflation-adjusted Bank of England index-linked data. A second direct-cost analysis evaluating the incremental cost-effective ratio (ICER) was modelled using the 2016 national mean (baseline) IVF and IUI success rates.OUTCOME MEASURES: LB, risks from IVF and IUI, and costs to gain 1 LB.RESULTS: This largest comprehensive analysis integrating success, risks and costs at a national level shows IUI is safer and more cost-effective than IVF treatment.IVF LB/cycle success was significantly better than IUI at 26.96% versus 11.49% (p<0.001) but the IUI success is much closer to IVF at 2.35:1, than previously considered. IVF remains a significant source of multiple gestation pregnancy (MGP) compared with IUI (RR (Relative Risk): 1.45 (1.31 to 1.60), p<0.001) as was the rate of twins (RR: 1.58, p<0.001).In 2016, IVF maternal and neonatal cost was 115 082 017 compared with 2 940 196 for IUI and this MGP-related perinatal cost is absorbed by the National Health Services. At baseline tariffs and success rates IUI was 42 558 cheaper than IVF to deliver 1LB with enhanced benefits with small improvements in IUI. Reliable levels of IVF-related MGP, OHSS (ovarian hyperstimulation syndrome), fetal reductions and terminations are revealed.CONCLUSION: IUI success rates are much closer to IVF than previously reported, more cost-effective in delivering 1 LB, and associated with lower risk of complications for maternal and neonatal complications. It is prudent to offer IUI before IVF nationally.

PMID: 32184314 [PubMed in process]

Continued here:
Observational retrospective study of UK national success, risks and costs for 319,105 IVF/ICSI and 30,669 IUI treatment cycles. - DocWire News

My life as one of the Gorleston Thomson triplets after being born on TV | Norfolk and Suffolk Lifestyle News – Eastern Daily Press

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PUBLISHED: 06:30 16 March 2020 | UPDATED: 13:44 16 March 2020

Emily Thomson

Growing up as a triplet. (from left to right) Emily Thomson, Megan Thomson and Georgia Thomson. Picture: Emily Thomson

Emily Thomson

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First let me get something out of the way. When someone asks me 'what is it like to be a triplet?' It's like asking 'what is it like to be me?' - I don't know any different.

Since before I can remember we have been referred to as 'the triplets', whether that was in school, by family members, friends or anyone who couldn't be bothered to say Emily, Megan and Georgia.

We are a single entity where one does not exist without the other - which is great when you're getting picked on in the playground and you have immediate backup but not when we are given a single birthday present and told 'it's to share'.

There are obvious difficulties with having three girls who are exactly the same age, from the terrible twos to moody adolescent teens, but my mum and dad, Sharon and Simon, did a pretty good job and I think they just about managed to keep their sanity.

'Dad they found another one'

My parents were originally told their chances of having another child, after having my brother Troy, were slim so they turned to In Vitro Fertilisation (IVF).

At that time, in 1996, my mum was told the success rate for IVF treatment was around 20pc, slightly lower compared to recent figures which reveal the chances of a live birth for a woman under 35 is 29pc.

But little did they know that their wish for a bigger family was about to be granted - and with a bit more than they bargained for.

To increase their chances of conceiving, doctors put three fertilised eggs back into my mum's womb and luckily for her all three worked.

The odds of conceiving triplets naturally is about 1 in 9,000, but in 1998 triplet births peaked in the UK with 297 because of IVF treatment.

Today the Human Fertilisation and Embryology Act (HFEA) has limited the number of embryos that can be transplanted, to prevent multiple births which have greater risks for the baby and mother.

My mum said: 'At one of the first scans they thought I was having twins. But I went back about a month later and they told me it was triplets. I didn't cry I just remember laughing.

'Simon was offshore at the time but when he got home I couldn't tell him because I was giggling hysterically and Troy just said, 'Dad they have found another one'.'

'I saw you on telly!'

Preparing for the arrival of a new baby can be an exciting and stressful time. Hormones are raging, ankles are swelling, and tempers are getting shorter. On top of that, my parents definitely didn't do things by halves, and from four months pregnant to one month before our arrival, ITV Anglia's cameras followed them around.

Then, on December 16, 1996, at the James Paget Hospital in Gorleston, the whole of Norfolk witnessed our birth.

Looking back at the footage is rather comical with the 90s hairdo's and my then 10-year-old brother wiping our bums and trying to muster some sort of excitement in front of the cameras. My family was literally the talk of the town. And 23 years later, Troy still thinks he was the star of the show.

My mum said: 'As soon as I went out with the triple buggy everybody stopped me and would want to know all about you or say they saw you on the TV. Getting from A to B was always quite a challenge.

'But I'm glad we did it. It's a really special thing that we have all the footage to look back on.'

You've got a friend in 'three'

The best thing about being a triplet growing up is that you were never alone. It was like a permanent sleep over with your best friends.

Bored? - always someone to play with.

Accidentally broken mum's new lipstick? - Blame someone else.

Argument with Georgia? - Megan, you're my new favourite.

We called ourselves the Power Puff Girls (also our favourite cartoon) because although we are not identical and are all completely different - from our hair colour to our friends at school - together we made the best team.

But that's not to say we haven't had our fair share of arguments and hair pulling over the years.

I asked my mum and dad to list some of their favourite memories of all of us in action.

Mum said: 'When you were quite young you worked out how to get over the stair gate by one standing on top of the other or you would push one another over by their bum.

'And at night you would climb into each other's cots because you didn't want to be on your own.

'On a Sunday I would make a roast and the family would sit around the table all afternoon and you would put on a show.

'Megan would be on the drums going mad. Georgia was obsessed with Shakira so she would be dancing and shaking her hips and Emily would be singing. You would have us in stitches.'

Dad added: 'I would come home from offshore and as I walked through the heliport, I saw three little girls darting towards me shouting daddy, daddy, daddy!

'There are so many moments we could list, but you were just best buddies and were forever causing mischief together. Even though you are all very different you have always had each other's backs.'

'Your poor mum!'

As an offshore worker, my dad spent a lot of his time away from home to provide for us all, leaving my mum, Troy and nan to juggle the workload. My mum shares both her struggles and the joy of raising a big family:

'The normal everyday things you take for granted were hard work, getting three babies ready and into car seats or a buggy. If I went shopping, someone would have to come with me because the buggy wouldn't fit through shop doors.

'I couldn't fit three of you into one trolley as well as the shopping so we had to use two trolleys. Everyday things were a lot harder because I couldn't physically manage you on my own.

'When I used to feed you it was like three little birds with their mouths open and I would go along the line and put a spoon in each mouth.

'But the guilt was the hardest thing. I had an only child before and I knew the attention Troy was used to.

'I couldn't cuddle any of you as much because I had so much to do. I was always on the go with bottles, cloth washing and nappy changing.

'But my solace was that you were never alone because you always had each other.

'The best part is I have three amazing daughters I am so proud of achieving everything they are putting their minds and hearts to.

'I like having a full house when the family is together. There is a lot to be said for having a big family, I just happened to get it over with in one big hit.'

A bond that can't be broken

Today I hear 'the triplets' less and less as we live apart and focus on our careers and lives as individuals.

I live in Norwich and work in journalism, Megan lives in Chester and works in law and Georgia is a cross-fit champion in Gorleston focusing on becoming a swimming teacher.

But after being cramped in a womb together you form a bond that not even time or distance can break, and I will always be grateful for that.

It's hard to summarise 23 years of life as a triplet and although it is somewhat of a unique story we are just a normal family - whatever that means.

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My life as one of the Gorleston Thomson triplets after being born on TV | Norfolk and Suffolk Lifestyle News - Eastern Daily Press

Merck conducts health media training in partnership with first lady of Namibia – Devdiscourse

Merck Foundation (Merck-Foundation.com) announces the First Lady of Namibia as Ambassador of Merck more than a Mother; Merck Foundation Calls for Applications in Namibia for "Merck More than a Mother" Media Recognition Awards 2020 for English speaking countries to break infertility stigma; Merck Foundation also Calls for Applications for 'Merck More Than a Mother' Fashion Awards from Namibia and rest of Africa.

Merck Foundation, the philanthropic arm of Merck KGaA Germany launched their programs and conducted their first "Merck Foundation Health Media Training" in Windhoek, Namibia in partnership with H.E. MONICA GEINGOS, The First Lady of Namibia and the Ambassador of Merck More Than a Mother together with Ministry of Health and Ministry of Education to break the stigma around infertility and build healthcare capacity in Namibia and rest of Africa.

Talking about the Health Media Training program Dr. Rasha Kelej, CEO of Merck Foundation and President of Merck More Than a Mother explained, "The Health Media Training program is a part of 'Merck More than a Mother' community awareness Program and is organized for the first time in Namibia for local media representatives and media students to emphasize they're critical role to create a culture shift and to be the voice of the voiceless in order to break the stigma around infertile women".

The First Lady of Namibia, H.E. Monica Geingos emphasized, "I am very excited to be appointed as ambassador of 'Merck more than a Mother' and to officially launch Merck Foundation programs in our country. Moreover, I am very happy to host this important training program. Media plays an important role in sensitizing our society. It can help in creating awareness about female & male infertility and in breaking the stigma around infertility".

The Health Media Training program is a part of 'Merck More than a Mother' community awareness Program and is organized for the first time in Namibia"It is important to initiate this important training program as I strongly believe that media has the capacity and ability to break the silence in our communities in a regular and effective basis." Dr. Rasha Kelej added.

The training was addressed by Fertility specialists who are Merck Foundation Alumni and stalwarts of Media.

It provided a great opportunity for journalists to listen to childless women's experience with infertility stigma and to meet the experts and also to network with each other and work as a unit to eradicate the stigma around infertility and its resulted domestic violence in Namibia and rest of Africa.

Merck Foundation together with Namibia's First Lady acknowledged the graduates of Merck Foundation programs in different fields of Oncology, Fertility and Embryology, Diabetes and Hypertension. and welcomed to be Merck Foundation Alumni for Namibia.

Merck Foundation in partnership with the Ministry of Health of Namibia has provided training for doctors from Namibia to be the first oncologist and fertility specialist in the public sector in the country. Moreover, they provided a year's online diploma in cardiovascular preventive medicines and a master's program in diabetes management for two doctors. Merck Foundation has committed to continue providing these specialty training to more doctors from different provinces in Namibia.

Merck Foundation recently announced the winners of 'Merck More Than a Mother' Media Recognition Awards 2019. They also announced for Namibian Media, the Call for Application of "Merck More Than a Mother" Media Recognition Awards 2020 for English speaking countries. The aim of these awards is to emphasize the role of media in enhancing the public engagement and understanding of infertility stigma and the need to change its social perception in African communities.

The applications are invited by media professionals to showcase along the year throughout their work to raise awareness about infertility prevention and breaking infertility stigma.

(With Inputs from APO)

Download The Devdiscourse News App for Latest News.

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Merck conducts health media training in partnership with first lady of Namibia - Devdiscourse

Child whisperer: Mary Mellos teaching legacy revered – WRAL.com

By STEPHEN MILLS, Times Argus

MONTPELIER, Vt. Mary Mello will say farewell to Union Elementary School after 50 years of teaching at the end of the school year.

Its very, very good work (in kindergarten) at the beginning, when they come in, theyre so full of enthusiasm, they think they know it all and they cant wait to learn more, and thats a wonderful setting for a teacher, Mello said. Your big job is to keep that going. You dont want them to lose that incredible curiosity about the world and the thrill for them when they learn something.

Born in 1946, Mello grew up in Boston and received a bachelors degree in English from Northeastern University in 1969 and a masters in education from Johnson State College in 1980.

Mello first started teaching in the 1969-1970 school year at a private school in Boston before moving to Vermont in 1972, when she started at UES, teaching first and second grades, and then in kindergarten from 1983 onward, where Mello said she found her calling.

Mello said when dealing with children with attention deficits or lack of focus, she would adopt a more individualistic approach to teaching and learning.

With young children, youre going to do less work with large groups and more work with small groups, so individualizing is a very natural part of what youre doing in kindergarten, Mello said. You would have to know your children pretty well to group them.

Even in math, were doing more small-group work, and we have set up for them to work independently when working with small groups, so you can take every child when they come in as far as they can go, she added.

Mello said she focused on teaching children to read to help them develop other academic skills later on.

If they can become excited and engaged about reading, I make sure that I keep that going, Mello said.

Milestones in education for Mello include a 1975 law that said special-education students should not be isolated from mainstream learning.

Ive seen things evolve over time ... with special education, which required that all students receive an education in the least-restrictive environment, Mello said. That meant that all children could be included in a public-school education.

Now, we find ways to support children so they can feel included and at home here, no matter what cognitive, physical difficulties, challenges they had. Vermont was a good pioneer in that, the idea that all children belong here and its our job to make sure we understand any challenges theyre dealing with, she added.

Mello also noted changes, over the years, in racial and ethnic diversity in the school system.

National Life is bringing in a lot of families from overseas, so our children are getting to know people they wouldnt have known until they were adults, Mello said. Weve had a lot of families from India, but Ive also taught children from Russia, Nicaragua, and two years ago, there were seven different languages spoken in my classroom such as Japanese, Russian, Hispanic, Indian (and) American Indian. It really does add a lot to the richness of the education of these children.

Mello said the school systems English language-learner teachers encourage children and families to preserve their lingual and cultural origins, and UES encourages children of different nationalities to participate in presentations about their family backgrounds, bring in flags of their home countries, and bring national dishes to potluck dinners with families to share with others.

You want to make every child know that theyre welcome and that they belong here, but you also dont want them to lose the things they have from having that special background, too, Mello said.

Another milestone for Mello was teaching the grandchild of a child she once taught.

It was only once, but that was a milestone when I had the grandson of one of the children I first taught, Mello said. I taught his grand aunt, and then a couple of years later, I had his grandfather and then I had his mother, and then two years ago, I had him, she said.

It seems like Im participating in something that teachers must have done a lot when you had the old one-roomed schoolhouses, that the school was the center of the community, and Miss whoever, she had your mother, she had your father, Mello added.

Fellow teacher Dena Cody has worked for 11 years with Mello on the kindergarten team at UES.

Mary has inspired me her dedication to the children and families in Montpelier is unwavering, Cody said. I always think of her as the child whisperer. She just has a way of working with children that helps them to grow and learn.

I always meet people and tell them I work at Union and Im a kindergarten teacher, and they always say, Is my teacher still there, Mrs. Mello? Just the other day, I was at the orthodontist and the dental hygienist said, Mary was my teacher, and this woman is so successful and happy and had such great things to say about her.

Cody recalled how Mello would teach an embryology class in kindergarten.

Ive only known her 11 years, and every year, shes hatched in every single class, Cody said. In the spring, shes always hatching chicks.

Cody also noted Mello has always maintained a rigorous professional development regimen through her years as a teacher.

She never stopped learning, she kept up with her studies ... best practices in math, best practices in literacy, best practices in science, Cody said. She always wanted to do what was best for kids, so if (that) meant a course, she took it. Thats an inspiration in itself. She herself is always learning.

Cody said Mello would also care for other students in the school.

She goes above and beyond for every kid in her class, and even in my class she looks after all of them, Cody said. Its not just her class. Shell peek out and see someone who needs help and is always there to help. Im really going to miss her, and its hard for me to even say. I wish she would stay. I dont want her to leave.

Mello taught Montpelier parent Emma Bay-Hansen and her brother, and her daughter.

Mary Mello was my kindergarten teacher 37 years ago in 1983, Bay-Hansen said. I was thrilled to learn that she would become my daughters kindergarten teacher a few years ago.

Mrs. Mello is the type of teacher that children fall in love with. My daughter goes back to visit her all the time. She is an incredible educator. Her patience, calming energy and depth of experience give her this magical quality a surreal, perfect version of what you dream a kindergarten teacher to be. We will all remember Mrs. Mello as one of the greatest teachers Montpelier has ever known, she added.

Mello said shes retiring to allow a younger generation to succeed her.

I think people tend to leave teaching sooner because they know they have to be very active, Mello said. I didnt want to get to the point where someone said, You cant do this anymore. I wanted to leave before then.

Mello plans to continue writing for The Bridge, and will volunteer to teach early literacy in a pre-school class at The Family Center in Montpelier. She also plans to spend more time with her grandchildren.

Online: https://bit.ly/2QlXRj6

___

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Child whisperer: Mary Mellos teaching legacy revered - WRAL.com

Merck Foundation launches first Health Media Training in partnership with the first lady of Namibia to break infertility stigma in the country #45586…

Talking about the Health Media Training program Dr Rasha Kelej, CEO of Merck Foundation and President of Merck More Than a Mother said "The Health Media Training program is a part of 'Merck More than a Mother' community awareness Program and is organized for the first time in Namibia for local media representatives and media students to emphasize their critical role to create a culture shift and to be the voice of the voiceless in order to break the stigma around infertile women."

The first lady of Namibia, HE Monica Geingos said "I am very excited to be appointed as ambassador of 'Merck more than a Mother' and to officially launch Merck Foundation programs in our country. Moreover, I am very happy to host this important training program. Media plays an important role is sensitizing our society. It can help in creating awareness about female and male infertility and in breaking the stigma around infertility."

"It is important to initiate this important training program as I strongly believe that media has the capacity and ability to break the silence in our communities in a regular and effective basis." Dr Rasha Kelej added.

The training was addressed by Fertility specialists who are Merck Foundation Alumni and stalwarts of Media.

It provided a great opportunity for the journalists to listen to childless women experience with infertility stigma and to meet the experts and also to network with each other and work as a unit to eradicate the stigma around infertility and its resulted domestic violence in Namibia and rest of Africa.

Merck Foundation together with Namibia's first lady acknowledged the graduates of Merck Foundation programs in different fields of Oncology, Fertility and Embryology, Diabetes and Hypertension. and welcomed to be Merck Foundation Alumni for Namibia.

Merck Foundation in partnership with Ministry of Health of Namibia has provided training for doctors from Namibia to be the first oncologist and fertility specialists in public sector in the country. Moreover, they provided one year online diploma in cardiovascular preventive medicines and master's program in diabetes management for two doctors. Merck Foundation has committed to continue providing these specialty training to more doctors from different provinces in Namibia.

Merck Foundation recently announced the winners of 'Merck More Than a Mother' Media Recognition Awards 2019. They also announced for Namibian Media, the Call for Application of "Merck More Than a Mother" Media Recognition Awards 2020 for English speaking countries. The aim of these awards is to emphasize the role of media in enhancing the public engagement and understanding of infertility stigma and the need to change its social perception in African communities.

The applications are invited by media professionals to showcase along the year their work to raise awareness about infertility prevention and breaking infertility stigma.

Who can apply?

Journalists from print, online, radio and multimedia platforms from Namibia and rest of English-speaking countries from Africa.

Last date of submission

Entries can be submitted till 15th June 2020.

How to apply? Entries can be submitted via email to

[emailprotected]

Sending multiple applications will increase the chances of winning the award.

"Merck More Than a Mother" is a strong movement that aims to empower infertile women through access to information, education and change of mind-sets. This powerful campaign supports governments in defining policies to enhance access to regulated, safe and effective fertility care. It defines interventions to break the stigma around infertile women and raises awareness about infertility prevention, management and male infertility. In partnership with African First Ladies, Ministries of Health, Information, Education and Gender, academia, policymakers, International fertility societies, media and art, the initiative also provides training for fertility specialists and embryologists to build and advance fertility care capacity in Africa and developing countries.

With "Merck More Than a Mother", we have initiated a cultural shift to de-stigmatize infertility on all levels By improving awareness, training local experts in the fields of fertility care and media, building advocacy in cooperation with African First Ladies and women leaders and by supporting childless women in starting their own small businesses. It's all about giving every woman the respect and the help she deserves to live a fulfilling life, with or without a child.

Merck Foundation is making history in many African countries where they never had fertility specialists or specialized fertility clinics before 'Merck More Than a Mother' intervention, to train the first fertility specialists such as; in Sierra Leone, Liberia, The Gambia, Niger, Chad, Guinea, Ethiopia and Uganda.

Merck Foundation launched new innovative initiatives to sensitize local communities about infertility prevention, male infertility with the aim to break the stigma of infertility and empowering infertile women as part of Merck More than a Mother COMMUNITY AWARENESS CAMPAIGN, such as;

*'Merck More than a Mother' Media Recognition Awards and Health Media Training

*'Merck More than a Mother' Fashion Awards

*'Merck More than a Mother' Film Awards

*Local songs with local artists to address the cultural perception of infertility and how to change it

*Children storybook, localized for each country

This story is provided by BusinessWire India. ANI will not be responsible in any way for the content of this article.

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Merck Foundation launches first Health Media Training in partnership with the first lady of Namibia to break infertility stigma in the country #45586...

In vivo Comparison of the Biodistribution and Toxicity of InP/ZnS Quan | IJN – Dove Medical Press

Li Li,1,2 Yajing Chen,1 Gaixia Xu,2,3 Dongmeng Liu,1 Zhiwen Yang,1 Tingting Chen,1 Xiaomei Wang,1 Wenxiao Jiang,1 Dahui Xue,1 Guimiao Lin1

1Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Laboratory of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences, Shenzhen University, Shenzhen 518055, Peoples Republic of China; 2Key Laboratory of Optoelectronics Devices and Systems of Ministry of Education/Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, Peoples Republic of China; 3Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518055, Peoples Republic of China

Correspondence: Guimiao LinSchool of Basic Medical Sciences, Shenzhen University Health Sciences Center, Shenzhen 518060, Peoples Republic of ChinaTel/ Fax +86-755-86671903Email gmlin@szu.edu.cn

Introduction: Indium phosphide (InP) quantum dots (QDs) have shown a broad application prospect in the fields of biophotonics and nanomedicine. However, the potential toxicity of InP QDs has not been systematically evaluated. In particular, the effects of different surface modifications on the biodistribution and toxicity of InP QDs are still unknown, which hinders their further developments. The present study aims to investigate the biodistribution and in vivo toxicity of InP/ZnS QDs.Methods: Three kinds of InP/ZnS QDs with different surface modifications, hQDs (QDs-OH), aQDs (QDs-NH2), and cQDs (QDs-COOH) were intravenously injected into BALB/c mice at the dosage of 2.5 mg/kg BW or 25 mg/kg BW, respectively. Biodistribution of three QDs was determined through cryosection fluorescence microscopy and ICP-MS analysis. The subsequent effects of InP/ZnS QDs on histopathology, hematology and blood biochemistry were evaluated at 1, 3, 7, 14 and 28 days post-injection.Results: These types of InP/ZnS QDs were rapidly distributed in the major organs of mice, mainly in the liver and spleen, and lasted for 28 days. No abnormal behavior, weight change or organ index were observed during the whole observation period, except that 2 mice died on Day 1 after 25 mg/kg BW hQDs treatment. The results of H&E staining showed that no obvious histopathological abnormalities were observed in the main organs (including heart, liver, spleen, lung, kidney, and brain) of all mice injected with different surface-functionalized QDs. Low concentration exposure of three QDs hardly caused obvious toxicity, while high concentration exposure of the three QDs could cause some changes in hematological parameters or biochemical parameters related to liver function or cardiac function. More attention needs to be paid on cQDs as high-dose exposure of cQDs induced death, acute inflammatory reaction and slight changes in liver function in mice.Conclusion: The surface modification and exposure dose can influence the biological behavior and in vivo toxicity of QDs. The surface chemistry should be fully considered in the design of InP-based QDs for their biomedical applications.

Keywords: InP/ZnS quantum dots, surface chemistry, in vivo, biodistribution, nanotoxicology

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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In vivo Comparison of the Biodistribution and Toxicity of InP/ZnS Quan | IJN - Dove Medical Press

Hero Proteins May Shield Other Proteins from Harm – The Scientist

Researchers at RIKEN and the University of Tokyo report the existence of a new class of proteins in Drosophila and human cell extracts that may serve as shields that protect other proteins from becoming damaged and causing disease. An excess of the proteins, known as Hero proteins, was associated with a 30 percent increase in the lifespan of Drosophila, according to the study, which was published last week (March 12) in PLOS Biology.

The discovery of Hero proteins has far-reaching implications, says Caitlin Davis, a chemist at Yale University who was not involved in the study, and should be considered both at a basic science level in biochemistry assays and for applications as a potential stabilizer in protein-based pharmaceuticals.

Nearly 10 years ago, Shintaro Iwasaki, then a graduate student studying biochemistry at the University of Tokyo, discovered a strangely heat-resistant protein in Drosophila that seemed to help stabilize another protein, Argonaute, in the face of high temperatures that would denature most proteins. Although he didnt publish the work at the time, Iwasaki called the new type of protein a Heat-resistant obscure (Hero) proteinnot because of their ability to rescue Argonaute from destruction, but because in Japan, the term hero means weak or not rigid, and Hero proteins dont have stiff 3-D structures like other proteins do. But recognition of a more widespread role for Hero proteins in protecting other molecules in the cell gives the name new meaning.

It is generally assumed that proteins are folded into three-dimensional structures, which determine their functions, says Kotaro Tsuboyama, a biochemist at the University of Tokyo and the lead author of the new study. But these 3-D structures are disrupted when the proteins are exposed to extreme conditions. When proteins are denatured, they lose the ability to function normally, and sometimes begin to aggregate, forming pathologic clumps that can lead to disease.

Hero proteins can survive these biologically challenging conditions. Heat-resistant proteins have been found in extremophilesorganisms known to live in extreme environmentsbut were thought to be rare in other organisms. In the new study, Tsuboyama and his team boiled lysates from Drosophila and human cell lines, identifying hundreds of Hero proteins that withstood the temperature.

The researchers selected six of these proteins and mixed them with client proteinsother functional proteins that on their own would be denatured by extreme conditionsbefore exposing them to high temperatures, drying, chemicals, and other harsh treatments. The Hero proteins prevented certain clients from losing their shape and function.

Next, the team tested the effects of Hero proteins in cellular models of two neurodegenerative disorders characterized by pathologic protein clumps: Huntingtons disease and amyotrophic lateral sclerosis (ALS). When the Hero proteins were present, there was a significant reduction in protein clumping in both models.

This is an extremely important finding as it may pave new therapeutic and preventive strategies for neurodegenerative diseases, such as Alzheimer and Parkinson diseases, Morteza Mahmoudi, who studies regenerative medicine at Michigan State University and was not involved in the research, writes in an email to The Scientist.

Lastly, the team genetically engineered Drosophila to produce an excess of Hero proteins. These flies lived up to 30 percent longer than their wildtype counterparts.

Not everyone is convinced that the Hero proteins play a major protective role. Although they show these proteins help their proven targets remain folded/shielded etc, I dont think theres a broader application at all, Nihal Korkmaz, who designs proteins at the University of Washington Institute of Protein Design and also did not participate in the study, tells The Scientist in an email. She adds that many proteins she works with can withstand high temperatures and the researchers dont mention at all if [Hero proteins] are found throughout the brain or in CSF [cerebrospinal fluid], where theyd be able to protect against Huntingtons or ALS.

The authors emphasized that there is a lot left to learn about the proteins. Each Hero protein seems able to protect some client proteins, but not all of them. Moreover, amino acid sequences differ considerably between Hero proteins, making it difficult to predict their functions. The researchers write in the study that they hope future studies will help them identify which clients each Hero might work with.

Whatever discoveries future work might hold, Tsuboyama says, the scientific communitys reaction to the teams new study has been consistent: Almost everyone says that Hero proteins are interesting but mysterious.

K. Tsuboyama et al., A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation,PLOS Biol,doi:10.1371/journal.pbio.3000632, 2020.

Emma Yasinski is a Florida-based freelance reporter. Follow her on Twitter@EmmaYas24.

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Hero Proteins May Shield Other Proteins from Harm - The Scientist