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Social distancing works just ask lobsters, ants and vampire bats – The Conversation Africa

Social distancing to combat COVID-19 is profoundly impacting society, leaving many people wondering whether it will actually work. As disease ecologists, we know that nature has an answer.

Animals as diverse as monkeys, lobsters, insects and birds can detect and avoid sick members of their species. Why have so many types of animals evolved such sophisticated behaviors in response to disease? Because social distancing helps them survive.

In evolutionary terms, animals that effectively socially distance during an outbreak improve their chances of staying healthy and going on to produce more offspring, which also will socially distance when confronted with disease.

We study the diverse ways in which animals use behaviors to avoid infection, and why behaviors matter for disease spread. While animals have evolved a variety of behaviors that limit infection, the ubiquity of social distancing in group-living animals tells us that this strategy has been favored again and again in animals faced with high risk of contagious disease.

What can we learn about social distancing from other animals, and how are their actions like and unlike what humans are doing now?

Social insects are some of the most extreme practitioners of social distancing in nature. Many types of ants live in tight quarters with hundreds or even thousands of close relatives. Much like our day care centers, college dormitories and nursing homes, these colonies can create optimal conditions for spreading contagious diseases.

In response to this risk, ants have evolved the ability to socially distance. When a contagious disease sweeps through their society, both sick and healthy ants rapidly change their behavior in ways that slow disease transmission. Sick ants self-isolate, and healthy ants reduce their interaction with other ants when disease is present in the colony.

Healthy ants even close rank around the most vulnerable colony members the queens and nurses by keeping them isolated from the foragers that are most likely to introduce germs from outside. Overall, these measures are highly effective at limiting disease spread and keeping colony members alive.

Many other types of animals also choose exactly who to socially distance from, and conversely, when to put themselves at risk. For example, mandrills a type of monkey continue to care for sick family members even as they actively avoid sick individuals to whom they are not related. In an evolutionary sense, caring for a sick family member may allow an animal to pass on its genes through that family members offspring.

Further, some animals maintain essential social interactions in the face of sickness while foregoing less critical ones. For example, vampire bats continue to provide food for their sick groupmates, but avoid grooming them. This minimizes contagion risk while still preserving forms of social support that are most essential to keeping sick family members alive, such as food sharing.

These nuanced forms of social distancing minimize costs of disease while maintaining the benefits of social living. It should come as no surprise that evolution favors them in many types of animals.

Human behavior in the presence of disease also bears the signature of evolution. This indicates that our hominid ancestors faced many of the same pressures from contagious disease that we are facing today.

Like social ants, we are protecting the most vulnerable members of our society from COVID-19 infection by ensuring that older individuals and those with pre-existing conditions stay away from potentially contagious people. Like monkeys and bats, we also practice nuanced social distancing, reducing non-essential social contacts while still providing essential care for sick family members.

There also are important differences. For example, in addition to caring for sick family members, humans sometimes increase their own risk by caring for unrelated individuals, such as friends and neighbors. And health care workers go further, actively seeking out and helping precisely those who many of us carefully avoid.

Altruism isnt the only behavior that distinguishes human response to disease outbreaks. Other animals must rely on subtle cues to detect illness among group members, but we have cutting-edge technologies that make it possible to detect pathogens rapidly and then isolate and treat sick individuals. And humans can communicate health threats globally in an instant, which allows us to proactively institute behaviors that mitigate disease. Thats a huge evolutionary advantage.

Finally, thanks to virtual platforms, humans can maintain social connections without direct physical contact. This means that unlike other animals, we can practice physical rather than social distancing, which lets us preserve some of the important benefits of group living while minimizing disease risk.

The evidence from nature is clear: Social distancing is an effective tool for reducing disease spread. It is also a tool that can be implemented more rapidly and more universally than almost any other. Unlike vaccination and medication, behavioral changes dont require development or testing.

However, social distancing can also incur significant and sometimes unsustainable costs. Some highly social animals, like banded mongooses, do not avoid group members even when they are visibly sick; the evolutionary costs of social distancing from their relatives may simply be too high. As we are currently experiencing, social distancing also imposes severe costs of many kinds in human societies, and these costs are often borne disproportionately by the most vulnerable people.

Given that social distancing can be costly, why do so many animals do it? In short, because behaviors that protect us from disease ultimately allow us to enjoy social living a lifestyle that offers myriad benefits, but also carries risks. By implementing social distancing when its necessary, humans and other animals can continue to reap the diverse benefits of social living in the long term, while minimizing the costs of potentially deadly diseases when they arise.

Social distancing can be profoundly disruptive to our society, but it can also stop a disease outbreak in its tracks. Just ask ants.

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Social distancing works just ask lobsters, ants and vampire bats - The Conversation Africa

Novel research explores interaction between engineered gene circuits and biological host cells – News-Medical.net

Reviewed by Emily Henderson, B.Sc.Apr 7 2020

Recent discoveries by two research teams in the Ira A. Fulton Schools of Engineering at Arizona State University are advancing the field of synthetic biology.

Assistant Professor Xiaojun Tian and Associate Professor Xiao Wang conducted a year-long collaboration with their laboratory groups in the School of Biological and Health Systems Engineering, one of the six Fulton Schools. Results from their novel research into ways that engineered gene circuits interact with biological host cells have been published this week in the scientific journal Nature Chemical Biology.

Synthetic biology applies engineering methods to design new biological networks or redesign aspects of existing biological systems. It is a rapidly emerging field of study, and many significant advances have been made during the past 20 years.

Early work included creating synthetic gene circuits and placing them within natural host cells.

But the concept of a circuit here is an abstract one. Imagine a sequence of genetic segments in which the first one encodes or produces a particular protein. That protein, in turn, can either activate or inhibit the expression or protein production from another segment in the genetic sequence. If you keep expanding this idea, you can imagine it's like a network."

Xiao Wang, Associate Professor,Ira A. Fulton Schools of Engineering at Arizona State University

It is this chain of influence or inducement that is functioning as a circuit, rather than the physical connections within the genetic sequence. However, previous research has focused on just the behaviors of engineered genetic circuits themselves, with little attention to the background or context represented by host cells.

"It is hard to predict how these interactions affect the functions of the engineered genetic circuits," Tian says, "not to mention how to control them and make the circuits operate as desired within complicated, real-life environments."

Indeed, these synthetic gene circuits generally work only in a laboratory environment, not in more lifelike conditions. And this limitation greatly inhibits the application of engineered gene circuits in clinical settings.

Seeking to advance the field in that practical direction, the new research by Tian and Wang explored the relationship between the synthetic gene circuits and their host cells. Specifically, they examined the impact of "memory" circuits implanted within host cells, and the influence of gene circuit "topologies," or the architecture of interconnections among circuit components, in relation to host cell growth.

In the context of this work, the idea of memory relates to the continuation of influence or inducement within an engineered gene circuit even with the absence of a stimulus.

"Think about a light switch in your house," Wang says. "The light stays on even when you remove your finger from the switch. We refer to that persistent state as memory."

Tian and Wang's new research revealed that memory circuit topologies are significantly influenced by host cell behavior.

"We verified that influences are exchanged between the gene circuit and the host cell," Tian says. "That is, the circuit impacts the host cell, which in return has an impact on the circuit. It's like a loop.

"But we also demonstrated that the impact on a circuit's functionality is dependent on its topology," he says. "So, one circuit topology shows better performance than others within a dynamic host environment."

Their discovery relating circuit topology to a host cell's impact on circuit function is a first in the field of synthetic biology, and it expands meaningful scientific understanding of these complex interactions.

"It paves the way for building robust, engineered gene circuits," Tian says. "These could one day enhance interventions against the metastasis of cancer, for example, by slowing the ability of cancer cells to translate their development."

Progressing from the research that Tian and Wang have published includes examining the impact of adding additional synthetic gene circuits or modules into host cells, which substantially elevates the level of complexity as modules compete for resources within the cellular system.

Wang says that the School of Biological and Health Systems Engineering within the Fulton Schools is particularly well-placed for discoveries in synthetic biology.

"We have a critical mass of dedicated people who are strategically invested in advancing this area of research for the long term," he says. "So, we are seeking to be a leader in this field."

Source:

Journal reference:

Zhang, R., et al. (2020) Topology-dependent interference of synthetic gene circuit function by growth feedback. Nature Chemical Biology. doi.org/10.1038/s41589-020-0509-x.

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Novel research explores interaction between engineered gene circuits and biological host cells - News-Medical.net

The Biology Behind Why Soil Smells so Good After It Rains – The National Interest

Did you ever wonder what causes that earthy smell that rises after a light summer rain? That mysterious scent has been called , and a main component of it is an organic compound called geosmin, which lingers around moist soil.

Geosmin comes from the ancient Greek geo, meaning earth, and osme, meaning smell. We use this scent as an ingredient in perfumes and it is what gives beetroot its earthy flavour. Geosmin can also be perceived as an off flavour in water and wine.

Animals can detect geosmin. Fruit flies, for example, dislike geosmin and they avoid anything that smells of it, possibly to avoid contaminated and potentially toxic food. But why is geosmin made in the soil? As part of a team of scientists from Sweden, the UK and Hungary, we discovered the fascinating biology behind this enigmatic compound.

Smells like (microbial) team spirit

Scientists have known since the 1960s that geosmin is made by microorganisms in the soil, primarily by bacteria with the scientific name Streptomyces. These bacteria are abundant in soil and are among natures best chemists, as they make a wide range of molecules (called specialised metabolites) from which many antibiotics derive. Streptomycetes and their close relatives make thousands of different specialised metabolites a true treasure trove for the potential discovery of new antibiotics.

It turns out that all streptomycetes have the gene for making geosmin, suggesting that it has an important function. But what do these bacteria gain from producing geosmin? This has been a longstanding mystery.

In our recent study, we found that geosmin is part of the chemical language in a mutually beneficial relationship between Streptomyces bacteria and springtails, insect-like organisms that are abundant in the ground.

We discovered this by asking if there could be soil organisms out there that would be attracted to the smell of Streptomyces. We baited traps with colonies of Streptomyces coelicolor and placed them in a field. Our traps captured several types of soil organisms, including spiders and mites. But strikingly, it was springtails that showed a particular preference for the traps baited with geosmin-producing Streptomyces.

Using a particular species of springtail, Folsomia candida, we tested how these creatures sense and react to geosmin. We placed electrodes on their tiny antennae (the average body size of springtail is about 2mm) and detected which smells stimulated them.

Geosmin and the related earthy odorant 2-methylisoborneol were sensed by the antennae, which is essentially the creatures nose. By studying springtails walking in Y-shaped glass tubes, we saw they had a strong preference for the arm that smelled of these earthy compounds.

The benefit for the animals seems to be that the odours lead them to a source of food. While geosmin-emitting microbes are often toxic to other organisms which avoid them, we found that it did no harm to the springtails we tested.

But how does producing these compounds benefit the bacteria? Streptomycetes normally grow as mycelium a network of long, branching cells that entwine with the soil they grow in. When they run out of nutrients or conditions in the soil deteriorate, the bacteria escape and spread to new places by making spores that can be spread by wind or water.

Our new finding is that spore production also includes the release of those earthy odorants that are attractive to springtails and that helps spread the spores by another route.

As the springtails grazed on a Streptomyces colony, we saw spores sticking to their cuticle (the outer surface of the animal). Springtails have a special anti-adhesive and water-repellent surface that bacteria typically dont stick to, but Streptomyces spores can adhere, probably because they have their own water-repellent surface layer. Spores eaten by the springtails can also survive and be excreted in faecal pellets.

So, springtails help spread Streptomyces spores as they travel through the soil, in much the same way pollinating bees are lured to visit flowers and take with them the pollen grains that adhere to their bodies and fertilise the other plants they visit. Birds eat attractive berries or fruits and help the plant to spread its seeds with their droppings.

Next time you encounter that earthy smell, let it be a reminder of the fascinating and extremely valuable bacteria that thrive in the ground beneath your feet. You might be listening in on an ancient type of communication between bacteria and the creatures that live with them in the soil.

Klas Flrdh, Professor of Molecular Cell Biology, Lund University and Paul Becher, Associate professor in Chemical Ecology, Swedish University of Agricultural Sciences

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Image: Reuters.

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The Biology Behind Why Soil Smells so Good After It Rains - The National Interest

UC Berkeley: What Do Soap Bubbles And Butterflies Have In Common? – Patch.com

Press release from the University of California, Berkeley:

April 8, 2020

The butterflies that Edith Smith selectively bred are much bluer and more iridescent than the wild Common Buckeye, which is mostly brown (see below). The breeding, UC Berkeley researchers discovered, changed the structure of the wing scales to produce a blue rather than golden structural color. (Photo courtesy of Edith Smith)

Edith Smith bred a bluer and shinier Common Buckeye at her butterfly farm in Florida, but it took University of California, Berkeley, graduate student Rachel Thayer to explain the physical and genetic changes underlying the butterfly's newly acquired iridescence.

In the process, Thayer discovered how relatively easy it is for butterflies to change their wing colors over just a few generations and found the first gene proven to influence the so-called "structural color" that underlies the iridescent purple, blue, green and golden hues of many butterflies.

Her findings are a starting point for new genetic approaches to investigate how butterflies produce intricate nanostructures with optical properties, which ultimately could help engineers develop new ways to produce photonic nanostructures for solar panels or iridescent colors for paints, clothing and cosmetics.

Structural color is different from pigment color, like that in your skin or on a canvas, which absorbs or reflects different colors of light. Instead, it comes from light's interaction with a solid material in the same way that a transparent bubble develops a colorful sheen. The light penetrates it and bounces back out, interfering with light reflected from the surface in a way that cancels out all but one color.

At the Shady Oak Butterfly Farm in Brooker, Florida, Smith's breeding experiments with the Common Buckeye (Junonia coenia) a mostly brown butterfly with showy, colorful spots, found throughout the United States and often raised by butterfly farmers for butterfly gardens or wedding ceremonies were ideal for Thayer's study of structural color.

A typical Common Buckeye butterfly, Junonia coenia, is brown because of brown pigment and golden structural color in the wing scales. (Photo by Nipam Patel)

"Edith noticed that sometimes these butterflies have just a few blue scales on the very front part of the forewing and started breeding the blue animals together," said Thayer, who is in UC Berkeley's Department of Integrative Biology. "So, effectively, she was doing an artificial selection experiment, guided by her own curiosity and intuition about what would be interesting."

In a paper appearing online today in the journal eLife, Thayer and Nipam Patel, a UC Berkeley professor of molecular and cell biology who is on leave as director of the Marine Biological Laboratory in Woods Hole, Massachusetts, describe the physical changes in wing scales associated with Smith's experiment on the Common Buckeye, and report one genetic regulator of blue iridescence.

"I especially loved the clear evolutionary context: being able to directly compare the 'before' and 'after' and piece together the whole story," Thayer said. "We know that blueness in J. coenia is a recent change, we know explicitly what the force of selection was, we know the time frame of the change. That doesn't happen every day for evolutionary biologists."

According to Thayer, hundreds of butterflies have been studied because of the showy structural color in their wing scales. The showiest is the blue morpho, with 5-inch wings of iridescent blue edged with black. Her study, however, focused on a less showy genus, Junonia, and found that iridescent color is common throughout the 10 species, even the drab ones. One unremarkable light gray butterfly, the pansy J. atlites, proved under a microscope to have iridescent rainbow-colored scales whose colors blend together into gray when viewed with the naked eye.

The 75% greater thickness of the scale lamina from the wing of a bred blue buckeye (red bar, top row, right) compared to the thickness of a scale from the brown wing of a typical buckeye (lower panel) is responsible for the blue color. Red arrows show wing area from which scales were obtained. (UC Berkeley images by Rachel Thayer)

One major lesson from the study, she said, is that "most butterfly patterns probably have a mix of pigment color and structural color, and which one has the strongest impact on wing color depends on how much pigment is there."

Thayer raised both the wild, brownish Common Buckeye and the cross-bred, bluer variety obtained from Smith. Using a state-of-the-art helium ion microscope, she imaged scales from the wings to see which scale structures are responsible for the color and to determine whether the color change was due to a change in structural color, or just a loss of brown pigment that allowed the blue color to stand out.

She found no difference in the amount of brown pigment on the scales, but a significant difference in the thickness of chitin, the strong polymer from which the scale is built and that also generates the structural color. In the wild buckeye, the thickness of the chitin layer was about 100 nanometers, yielding a golden hue that blended with the brown pigment. The bluer buckeye had chitin about 190 nanometers thick about the thickness of a soap bubble that produced a blue iridescence that outshined the brown pigment.

Breeding turned a brown area of the buckeye's wing (left) much bluer (right) as the individual scale lamina thickened, replacing a golden structural color with blue. (UC Berkeley images by Rachel Thayer)

"They are actually creating the color the same way a soap bubble iridescence works; it's the same phenomenon physically," Thayer said.

She also found that, though the scales from the Junonia butterflies have an elaborate microscopic structure, structural color comes from the bottom, or base, of the scale.

"That is not intuitive, because the top part of the scale has all of these curves and grooves and details that really catch your eye, and the most famous structural colors are elaborate structures, often in the top part of the scale," she said. "But the simple, flat layer at the bottom of the scale controls structural coloration in each species we checked."

"The color comes down to a relatively simple change in the scale: the thickness of the lamina," said Patel. "We believe that this will be a genetically tractable system that can allow us to identify the genes and developmental mechanisms that can control structural coloration."

Thayer also investigated the scales of mutant buckeyes created by Cornell University researchers that lacked a key gene, called optix, that controls color. The micrograph images demonstrated that lack of the gene also increased the thickness of the thin film of chitin in the scales, creating a blue color. Optix is a regulatory gene that controls many other butterfly genes, which Thayer will be looking at next.

This video produced by the Marine Biological Laboratory explains how a selective mating experiment by a curious butterfly farmer led scientists to a deeper understanding of how butterfly wing color is created and evolves. (Video by Emily Greenhalgh, MBL)

"One thing that I thought was cool about our findings was seeing that the same mechanism that has recurred over millions of years of butterfly evolution could be reproduced really rapidly in (Smith's) artificial section experiment," she said. "That says that color evolving by changes in lamina thickness is a repeatable, important phenomenon."

Frances Allen, a research scientist in UC Berkeley's Department of Materials Science and Engineering, is also a co-author of the paper. The work was supported by the National Science Foundation (DEB-1601815, DGE-1106400).

This press release was produced by the University of California, Berkeley. The views expressed here are the author's own.

Does 5G wireless service exacerbate the coronavirus? Is hydroxychloroquine, used to treat malaria and lupus, a silver bullet for COVID-19?

By Beth Dalbey, Patch Staff

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UC Berkeley: What Do Soap Bubbles And Butterflies Have In Common? - Patch.com

How do I improve air quality in my home to protect against the coronavirus? – cleveland.com

CLEVELAND, Ohio -- While bad air quality could mean major implications for the coronavirus, you can help boost air quality at home during the pandemic, to protect yourself. Small steps like buying a new air filter or breaking out the vacuum cleaner more frequently can make a difference.

The nationwide study showed that a unit increase of atmospheric particulate matter led to a 15% increase in the COVID-19 death rate. That poses a problem in areas like San Francisco, New York and Cleveland, where at times air quality can match industrial, highly-polluted China.

Cleveland recently ranked as one of the worst cities for pollution caused ozone and fine particulates in recent studies released by the American Lung Association, meaning the implications of this study could be severe.

Air pollution can boost levels of inflammation in the lungs, making patients more vulnerable to other infections.

Cuyahoga County has the highest coronavirus case numbers in the state at 960. Franklin and Hamilton counties are second and third and are home to other major Ohio cities Columbus and Cincinnati.

I think now were starting to appreciate that in areas of lower socio-economic class, in areas where people live in tighter quarters, there is there are higher levels of air pollution but also higher rates of COVID-19 and now we know from this paper, higher rates of deaths from the virus," Loren Wold, a professor in Ohio State Universitys department of Physiology and Cell Biology.

Wold said that researchers are looking to map air pollution levels with levels of virus infection.

We do know that Cleveland, Columbus and Cincinnati there is a a track of pollutants that tend to run along the river systems. Mostly that is due to the way the air moves within the state. We know that the level is only higher in the large cities in Ohio.

Ohios stay-at-home order, which reduces all non-essential businesses to basic operations, shut down some of the businesses that were boosting air pollutant levels. Wold said theres been a slight drop in pollution, but that some people are still driving, which heavily contributes.

Even though officials now recommend that Ohioans wear masks in public, a typical mask isnt as effective as filtering out particulates in the air. The pores in the fabric are too large, Wold said. Specialized masks are available with a prescription for those with respiratory problems.

Inflammation and lung damage are also linked to smoking, which could be another factor in who is more vulnerable to severe outcomes from COVID-19. Indoor air humidity could also be important, because dry air could affect the viruss ability to travel and bodys defenses against the virus.

Social distancing and hygiene are still the primary ways to stop the spread of the coronavirus. Below are some recommendations for improving air quality in your home, based on Wolds recommendations and advice from Harvard and the EPA:

-- if you have a forced-air heating system, be sure to change the filter

-- buy a HEPA filter, which can filter out high particulates through forcing air through a fine mesh

-- keep the house clean, vacuuming and dusting and cleaning surfaces more regularly to remove dust, particulates and other lung irritants, as well as prevent the spread of coronavirus

-- check air quality online each day. If pollution is too high, consider exercising at off hours or staying inside to prevent irritation or trouble breathing

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How do I improve air quality in my home to protect against the coronavirus? - cleveland.com

Trinity and AIB join forces for dedicated Covid-19 Research Hub – Siliconrepublic.com

AIB has pledged 2.4m to help accelerate Trinity College Dublins immunology project tackling the Covid-19 pandemic.

Trinity College Dublin will establish a new research hub at the university in collaboration with AIB, after the bank pledged 2.4m to accelerate the project.

The new research hub will be located within the Trinity Biomedical Sciences Institute and will play a critical role in the delivery of the Trinity Covid-19 Immunology Project. The hub will involve immunologists and infectious disease clinicians from St Jamess Hospital in Dublin.

While the immunology project was already in the pipeline, this injection of funding has accelerated plans.The project will be a collaboration with the Trinity Translational Medicine Institute and the Clinical Research Facility based on the St Jamess Hospital campus.

AIBs CEO, Colin Hunt, said its an ambitious and pioneering project that merits every assistance in developing solutions for the short, medium and long term. Time is of the essence and our support for the research hub begins now, he added.

The research will focus on addressing the design of new drugs and vaccines, the supply and validation of commercial antibody testing kits, the development of rapid antibody testing and the investigation of the immune response in infected and recovered Covid-19 patients.

The project will be led by Prof Kingston Mills and Prof Aideen Long and will involve scientists and immunologists working on basic and applied research, including infectious disease consultants, immunologists, respiratory disease physicians and intensive care specialists working with Covid-19 patients.

Mills said: This will provide key information for the design of vaccines and immunotherapeutic drugs for controlling the often fatal inflammation in Covid-19 patients, and will assist in developing and validating new assays for detecting antibody responses to the virus, thereby identifying those that are immune and therefore safe to return to work.

The research will also benefit from Trinitys global network of collaborations and contacts in universities such as MIT in Boston and Utrecht University in The Netherlands. The hub will continue to accept contributions from other public and private sources.

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UB researchers step up to help break bottlenecks in COVID-19 testing – UB Now: News and views for UB faculty and staff – University at Buffalo…

Its a national issue: not enough tests or testing materials for COVID-19. To most of us, its another thing that feels awful, but out of our control during this unprecedented global pandemic.To members of the research community, its a call to action.Anthony A. Campagnari, SUNY Distinguished Professor in the Department of Microbiology and Immunology, heard that call when a colleague sent an email noting a need for more viral transport media, or VTM. Campagnari and his colleagues throughout the Jacobs School of Medicine and Biomedical Sciences at UB quickly teamed up. The result? They are now providing Kaleida Health with approximately 1,000 tubes of VTM each week.The email came from John Tomaszewski, SUNY Distinguished Professor and Peter A. Nickerson, PhD, Chair of the Department of Pathology and Anatomical Sciences in the Jacobs School and clinical chief of service at Kaleida Health Laboratories, a position that puts him at the heart of the COVID-19 testing process for Kaleida Health.They were fortunate: Kaleida Health had agreed years before to host at its Center for Laboratory Medicine an important piece of laboratory instrumentation called a polymerase chain reaction (PCR) machine. The machine allows for the detection of viral nucleic acids, and the methodology can be designed to specifically identify COVID-19 in clinical samples. The machine was provided by Abbott Laboratories to support the clinical research of Andrew Talal, professor of medicine in the Jacobs School and a leading researcher on hepatitis C virus.There have been issues with laboratory testing capacity everywhere, says Tomaszewski, also president of UBMD Pathology. This partnership between UB and Kaleida Health came about because of the clinical trial research of one of our faculty members and now its become a critical piece of the communitys COVID-19 response.Adds Talal: This was an opportunity for research and clinical care to proceed harmoniously, so that during this pandemic, we could take advantage of the placement of this machine within Kaleida as a research tool. The machine has traditionally been used to measure the level of hepatitis C virus in the blood and liver, investigation that is supported by the Kaleida Health Foundation. This is an illustration of how the foundations support is directly enabling us to improve the health of the community.We have leveraged this machine to do testing for COVID-19 and its the only reason we are doing any testing, Tomaszewski notes. This is because of the UB academic health center partnership and the interaction between the clinical research at UB and the clinical treatment thats going on at Kaleida Health.

But while the machine increased the areas testing capacity, there was not enough viral transport media (VTM) to support the samples that needed testing.In the current COVID-19 pandemic, the nasopharyngeal swab that is used to take a sample from the patient is placed directly into a tube of sterile VTM, says Campagnari, senior associate dean for research in the Jacobs School. So every COVID-19 test that involves a nasal swab utilizes VTM.Viral transport media are critical for any tests involving viral detection, he explains; this media contains proteins that stabilize the virus until the sample can be properly analyzed. VTM includes buffers to control pH, as well as antibiotics and antifungals to prevent or eliminate bacteria or fungi from contaminating the clinical sample.Other Jacobs School colleagues were reaching out, too. Jay Bangs, chair microbiology and immunology, sent an email asking if anyone had the chemical reagents needed to make the VTM.Almost immediately, faculty responded. Elsa Bou Ghanem, an assistant professor in the department, provided enough Hanks Balanced Salt Solution and heat-inactivated Fetal Bovine Serum, two major components in VTM, to make approximately 25 liters enough for 8,000 tubes.Inquiries about additional reagents resulted in more donations from the Department of Biochemistry Stockroom, thanks to Mark OBrian, chair of biochemistry, and staffers Amy Raslawsky and Dawn Rowland, who provided the essential antibiotic.Campagnari then connected with Nicholas Ingrao at Kaleida labs, who provided the antifungal agent they needed to complete the VTM. Nicole Luke-Marshall, research assistant professor, and Lisa Hansen, both of whom are part of Campagnaris lab group and have extensive experience in proper sterile technique, also volunteered to help.It was truly amazing how quickly everyone came together, says Campagnari. Within a few days, we had all the essential reagents, we had assembled a team and we were making VTM.

Campagnari and his team followed what they termed a simple recipe, adding each reagent at the proper concentration, filter sterilizing the solution and then portioning 3 milliliters of VTM into 15 milliliters sterile tubes. It requires working in a biosafety cabinet with an automatic pipettor and disposable pipettes. Again, Campagnari says, they were fortunate because Tom Russo, professor and chief of the Division of Infectious Disease in the Department of Medicine, and Chelsie Armbruster, assistant professor of microbiology and immunology, let them use their biosafety cabinets. As we now had three biosafety cabinets, we were also able to practice social distancing while making the VTM, he adds.

Once the samples are prepared, each tube must be properly labelled.While it is somewhat tedious and time consuming, it is not difficult, Campagnari says.He notes that other regions experiencing VTM shortages should identify research labs in the vicinity that also might be able to help.Campagnaris team at the Jacobs School has now committed to providing Kaleida Health with about 1,000 tubes of VTM per week for as long as necessary.Many individuals from the Jacobs School rapidly responded to this shortage by dedicating their time, their reagents and their facilities, which is an excellent example of teamwork involving a combination of both clinical and basic science expertise, Campagnari says.

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UB researchers step up to help break bottlenecks in COVID-19 testing - UB Now: News and views for UB faculty and staff - University at Buffalo...

One Hundred Years of Crisis – Journal #108 April 2020 – E-Flux

If philosophy ever manifested itself as helpful, redeeming, or prophylactic, it was in a healthy culture. The sick, it made ever sicker.Nietzsche, Philosophy in the Tragic Age of the Greeks

In 1919, after the First World War, the French poet Paul Valry in Crisis of the Spirit wrote: We later civilizations we too know that we are mortal.1 It is only in such a catastrophe, and as an aprs coup, that we know we are nothing but fragile beings. One hundred years later, a bat from Chinaif indeed the coronavirus comes from batshas driven the whole planet into another crisis. Were Valry still alive, he wouldnt be allowed to walk out of his house in France.

The crisis of the spirit in 1919 was preceded by a nihilism, a nothingness, that haunted Europe before 1914. As Valry wrote of the intellectual scene before the war: I see nothing! Nothing and yet an infinitely potential nothing. In Valrys 1920 poem Le Cimetire Marin (Graveyard by the Sea) we read a Nietzschean affirmative call: The wind is rising! We must try to live! This verse was later adopted by Hayao Miyazaki as the title of his animation film about Jiro Horikoshi, the engineer who designed fighter aircraft for the Japanese Empire that were later used in the Second World War. This nihilism recursively returns in the form of a Nietzschean test: a demon invades your loneliest loneliness and asks if you want to live in the eternal recurrence of the samethe same spider, the same moonlight between the trees, and the same demon who asks the same question. Any philosophy that cannot live with and directly confront this nihilism provides no sufficient answer, since such a philosophy only makes the sick culture sicker, or in our time, withdraws into laughable philosophical memes circulating on social media.

The nihilism Valry contested has been constantly nurtured by technological acceleration and globalization since the eighteenth century. As Valry wrote towards the end of his essay:

But can the European spiritor at least its most precious contentbe totally diffused? Must such phenomena as democracy, the exploitation of the globe, and the general spread of technology, all of which presage a deminutio capitis for Europe must these be taken as absolute decisions of fate?2

This threat of diffusionwhich Europe may have attempted to affirmis no longer something that can be confronted by Europe alone, and probably will never be completely overcome again by the European tragist spirit.3 Tragist is first of all related to Greek tragedy; it is also the logic of the spirit endeavoring to resolve contradictions arising from within. In What Begins after the End of the Enlightenment? and other essays, I have tried to sketch out how, since the Enlightenment, and after the decline of monotheism, the latter was replaced by a mono-technologism (or techno-theism), which has culminated today in transhumanism.4 We, the moderns, the cultural heirs to the European Hamlet (who, in Valrys Crisis of the Spirit, looks back at the European intellectual legacy by counting the skulls of Leibniz, Kant, Hegel, and Marx), one hundred years after Valrys writing, have believed and still want to believe that we will become immortal, that we will be able to enhance our immune system against all viruses or simply flee to Mars when the worst cases hit. Amidst the coronavirus pandemic, researching travel to Mars seems irrelevant for stopping the spread of the virus and saving lives. We mortals who still inhabit this planet called earth may not have the chance to wait to become immortal, as the transhumanists have touted in their corporate slogans. A pharmacology of nihilism after Nietzsche is still yet to be written, but the toxin has already pervaded the global body and caused a crisis in its immune system.

For Jacques Derrida (whose widow, Marguerite Derrida, recently died of coronavirus), the September 11, 2001 attack on the World Trade Center marked the manifestation of an autoimmune crisis, dissolving the techno-political power structure that had been stabilized for decades: a Boeing 767 was used as a weapon against the country that invented it, like a mutated cell or virus from within.5 The term autoimmune is only a biological metaphor when used in the political context: globalization is the creation of a world system whose stability depends on techno-scientific and economic hegemony. Consequently, 9/11 came to be seen as a rupture which ended the political configuration willed by the Christian West since the Enlightenment, calling forth an immunological response expressed as a permanent state of exceptionwars upon wars. The coronavirus now collapses this metaphor: the biological and the political become one. Attempts to contain the virus dont only involve disinfectant and medicine, but also military mobilizations and lockdowns of countries, borders, international flights, and trains.

In late January, Der Spiegel published an issue titled Coronavirus, Made in China: Wenn die Globalisierung zur tdlichen Gefahr wird (When globalization becomes deadly danger), illustrated with an image of a Chinese person in excessive protective gear gazing at an iPhone with eyes almost closed, as if praying to a god.6 The coronavirus outbreak is not a terrorist attackso far, there has been no clear evidence of the viruss origin beyond its first appearance in Chinabut is rather an organological event in which a virus attaches to advanced transportation networks, travelling up to 900 km per hour. It is also an event that seems to return us to the discourse of the nation-state and a geopolitics defined by nations. By returning, I mean that, first of all, the coronavirus has restored meaning to borders that were seemingly blurred by global capitalism and the increasing mobility promoted by cultural exchange and international trade. The global outbreak has announced that globalization so far has only cultivated a mono-technological culture that can only lead to an autoimmune response and a great regression. Secondly, the outbreak and the return to nation-states reveal the historical and actual limit of the concept of the nation-state itself. Modern nation-states have attempted to cover up these limits through immanent infowars, constructing infospheres that move beyond borders. However, rather than producing a global immunology, on the contrary, these infospheres use the apparent contingency of the global space to wage biological warfare. A global immunology that we can use to confront this stage of globalization is not yet available, and it may never become available if this mono-technological culture persists.

During the 2016 refugee crisis in Europe, the philosopher Peter Sloterdijk criticized Germanys chancellor Angela Merkel in an interview with the magazine Cicero, saying, We have yet to learn to glorify borders Europeans will sooner or later develop an efficient common border policy. In the long run the territorial imperative prevails. After all, there is no moral obligation to self-destruction.7 Even if Sloterdijk was wrong in saying that Germany and the EU should have closed their borders to refugees, in retrospect one may say that he was right about the question of borders not being well thought out. Roberto Esposito has clearly stated that a binary (polar) logic persists concerning the function of borders: one insists on stricter control as an immunological defense against an outer enemya classical and intuitive understanding of immunology as opposition between the self and the otherwhile the other proposes the abolition of borders to allow freedom of mobility and possibilities of association for individuals and goods. Esposito suggests that neither of the two extremesand it is somewhat obvious todayis ethically and practically undesirable.8

The outbreak of the coronavirus in Chinabeginning in mid-November until an official warning was announced in late January, followed by the lockdown of Wuhan on January 23led immediately to international border controls against Chinese or even Asian-looking people in general, identified as carriers of the virus. Italy was one of the first countries to impose a travel ban on China; already in late January, Romes Santa Cecilia Conservatory suspended oriental students from taking classes, even those who had never in their life been to China. These actswhich we may call immunologicalare conducted out of fear, but more fundamentally out of ignorance.

In Hong Kongright next to Shenzhen in Guangdong province, one of the major outbreak regions outside Hubei provincethere were strong voices urging the government to close the border with China. The government refused, citing the World Health Organization advising countries to avoid imposing travel and trade restrictions on China. As one of two special administrative regions of China, Hong Kong SAR is not supposed to oppose China nor add to its recent burden of underwhelming economic growth. And yet, some Hong Kong restaurants posted notices on their doors announcing that Mandarin-speaking clients were unwelcome. Mandarin is associated with virus-carrying Mainland Chinese people, therefore the dialect is considered a sign of danger. A restaurant that under normal circumstances is open to anyone who can afford it is now only open to certain people.

All forms of racism are fundamentally immunological. Racism is a social antigen, since it clearly distinguishes the self and the other and reacts against any instability introduced by the other. However, not all immunological acts can be considered racism. If we dont confront the ambiguity between the two, we collapse everything into the night where all cows are grey. In the case of a global pandemic, an immunological reaction is especially unavoidable when contamination is facilitated by intercontinental flights and trains. Before the closing of Wuhan, five million inhabitants had escaped, involuntarily transporting the virus out of the city. In fact, whether one is labelled as being from Wuhan is irrelevent, since everyone can be regarded as suspect, considering that the virus can be latent for days on a body without symptoms, all the while contaminating its surroundings. There are immunological moments one cannot easily escape when xenophobia and micro-fascisms become common on streets and in restaurants: when you involuntarily cough, everyone stares at you. More than ever, people demand an immunospherewhat Peter Sloterdijk suggestedas protection and as social organization.

It seems that immunological acts, which cannot simply be reduced to racist acts, justify a return to bordersindividual, social, and national. In biological immunology as well as political immunology, after decades of debate on the selfother paradigm and the organismic paradigm, modern states return to border controls as the simplest and most intuitive form of defense, even when the enemy is not visible.9 In fact, we are only fighting against the incarnation of the enemy. Here, we are all bound by what Carl Schmitt calls the political, defined by the distinction between friend and enemya definition not easily deniable, and probably strengthened during a pandemic. When the enemy is invisible, it has to be incarnated and identified: firstly the Chinese, the Asians, and then the Europeans, the North Americans; or, inside China, the inhabitants of Wuhan. Xenophobia nourishes nationalism, whether as the self considering xenophobia an inevitable immunological act, or the other mobilizing xenophobia to strengthen its own nationalism as immunology.

The League of Nations was founded in 1919 after the First World War, and was later succeeded by the United Nations, as a strategy to avoid war by gathering all nations into a common organization. Perhaps Carl Schmitts criticism of this attempt was accurate in claiming that the League of Nations, which had its one-hundred-year anniversary last year, mistakenly identified humanity as the common ground of world politics, when humanity is not a political concept. Instead, humanity is a concept of depoliticization, since identifying an abstract humanity which doesnt exist can misuse peace, justice, progress, and civilization in order to claim these as ones own and to deny the same to the enemy.10 As we know, the League of Nations was a group of representatives from different countries that was unable to prevent one of the greatest catastrophes of the twentieth century, the Second World War, and was therefore replaced by the United Nations. Isnt the argument applicable to the World Health Organization, a global organization meant to transcend national borders and provide warnings, advice, and governance concerning global health issues? Considering how the WHO had virtually no positive role in preventing the spread of coronavirusif not a negative role: its general director even refused to call it a pandemic until it was evident to everyonewhat makes the WHO necessary at all? Naturally, the work of professionals working in and with the organization deserves enormous respect, yet the case of the coronavirus has exposed a crisis in the political function of the larger organization. Worse still, we can only criticize such a gigantic money-burning global governing body for its failure on social media, like shouting into the wind, but no one has the capacity to change anything, as democratic processes are reserved for nations.

If we follow Schmitt, the WHO is primarily an instrument of depoliticization, since its function to warn of coronavirus could have been done better by any news agency. Indeed, a number of countries acted too slowly by following the WHOs early judgment of the situation. As Schmitt writes, an international representational governing body, forged in the name of humanity, does not eliminate the possibility of wars, just as it does not abolish states. It introduces new possibilities for wars, permits wars to take place, sanctions coalition wars, and by legitimizing and sanctioning certain wars it sweeps away many obstacles to war.11 Isnt the manipulation of global governance bodies by world powers and transnational capital since the Second World War only a continuation of this logic? Hasnt this virus that was controllable at the beginning sunken the world into a global state of war? Instead, these organizations contribute to a global sickness where mono-technological economic competition and military expansion are the only aim, detaching human beings from their localities rooted in the earth and replacing them with fictive identities shaped by modern nation-states and infowars.

The concept of the state of exception or state of emergency was originally meant to allow the sovereign to immunize the commonwealth, but since 9/11 it had tended towards a political norm. The normalization of the state of emergency is not only an expression of the absolute power of the sovereign, but also of the modern nation-state struggling and failing to confront the global situation by expanding and establishing its borders through all available technological and economic means. Border control is an effective immunological act only if one understands geopolitics in terms of sovereigns defined by borders. After the Cold War, increasing competition has resulted in a mono-technological culture that no longer balances economic and technological progress, but rather assimilates them while moving towards an apocalyptic endpoint. Competition based on mono-technology is devastating the earths resources for the sake of competition and profit, and also prevents any player from taking different paths and directionsthe techno-diversity that I have written about extensively. Techno-diversity doesnt merely mean that different countries produce the same type of technology (mono-technology) with different branding and slightly different features. Rather, it refers to a multiplicity of cosmotechnics that differ from each other in terms of values, epistemologies, and forms of existence. The current form of competition that uses economic and technological means to override politics is often attributed to neoliberalism, while its close relative transhumanism considers politics only a humanist epistemology soon to be overcome through technological acceleration. We arrive at an impasse of modernity: one cannot easily withdraw from such competition for fear of being surpassed by others. It is like the metaphor of modern man that Nietzsche described: a group permanently abandons its village to embark on a sea journey in pursuit of the infinite, but arrive at the middle of the ocean only to realize that the infinite is not a destination.12 And there is nothing more terrifying than the infinite when there is no longer any way of turning back.

The coronavirus, like all catastrophes, may force us to ask where we are heading. Though we know we are only heading to the void, still, we have been driven by a tragist impulse to try to live. Amidst intensified competition, the interest of states is no longer with their subjects but rather economic growthany care for a population is due to their contributions to economic growth. This is self-evident in how China initially tried to silence news about the coronavirus, and then, after Xi Jinping warned that measures against the virus damage the economy, the number of new cases dramatically dropped to zero. It is the same ruthless economic logic that made other countries decide to wait and see, because preventive measures such as travel restrictions (which the WHO advised against), airport screenings, and postponing the Olympic Games impact tourism.

The media as well as many philosophers present a somewhat naive argument concerning the Asian authoritarian approach and the allegedly liberal/libertarian/democratic approach of Western countries. The Chinese (or Asian) authoritarian wayoften misunderstood as Confucian, though Confucianism is not at all an authoritarian or coercive philosophyhas been effective in managing the population using already widespread consumer surveillance technologies (facial recognition, mobile data analysis, etc.) to identify the spread of the virus. When the outbreaks started in Europe, there was still debate on whether to use personal data. But if we are really to choose between Asian authoritarian governance and Western liberal/libertarian governance, Asian authoritarian governance appears more acceptable for facing further catastrophes, since the libertarian way of managing such pandemics is essentially eugenicist, allowing self-selection to rapidly eliminate the older population. In any case, all of these cultural essentialist oppositions are misleading, since they ignore the solidarities and spontaneity among communities and peoples diverse moral obligations to the elderly and family; yet this type of ignorance is necessary for vain expressions of ones own superiority.

But where else can our civilization move? The scale of this question mostly overwhelms our imagination, leaving us to hope, as a last resort, that we can resume a normal life, whatever this term means. In the twentieth century, intellectuals looked for other geopolitical options and configurations to surpass the Schmittian concept of the political, as Derrida did in his Politics of Friendship, where he responded to Schmitt by deconstructing the concept of friendship. Deconstruction opens an ontological difference between friendship and community to suggest another politics beyond the friendenemy dichotomy fundamental to twentieth-century political theory, namely hospitality. Unconditional and incalculable hospitality, which we may call friendship, can be conceived in geopolitics as undermining sovereignty, like when the Japanese deconstructionist philosopher Kjin Karatani claimed that the perpetual peace dreamed of by Kant would only be possible when sovereignty could be given as a giftin the sense of a Maussian gift economy, which would follow the global capitalist empire.13 However, such a possibility is conditioned by the abolition of sovereignty, in order words, the abolition of nation-states. For this to happen, according to Karatani, we would probably need a Third World War followed by an international governing body with more power than the United Nations. In fact, Angela Merkels refugee policy and the one country, two systems brilliantly conceived by Deng Xiaoping are moving towards this end without war. The latter has the potential to become an even more sophisticated and interesting model than the federal system. However the former has been a target of fierce attacks and the latter is in the process of being destroyed by narrow-minded nationalists and dogmatic Schmittians. A Third World War will be the quickest option if no country is willing to move forward.

Before that day arrives, and before an even more serious catastrophe brings us closer to extinction (which we can already sense), we may still need to ask what an organismic global immune system could look like beyond simply claiming to coexist with the coronavirus.14 What kind of co-immunity or co-immunism (the neologism that Sloterdijk proposed) is possible if we want globalization to continue, and to continue in a less contradictory way? Sloterdijks strategy of co-immunity is interesting but politically ambivalentprobably also because it is not sufficiently elaborated in his major worksoscillating between a border politics of the far-right Alternative fr Deutschland (AfD) party and Roberto Espositos contaminated immunity. However, the problem is that if we still follow the logic of nation-states, we will never arrive at a co-immunity. Not only because a state is not a cell nor an organism (no matter how attractive and practical this metaphor is for theorists), but also more fundamentally because the concept itself can only produce an immunity based on friend and enemy, regardless of whether it assumes the form of international organizations or councils. Modern states, while composed of all their subjects like the Leviathan, have no interest beyond economic growth and military expansion, at least not before the arrival of a humanitarian crisis. Haunted by an imminent economic crisis, nation-states become the source (rather than the target) of manipulative fake news.

Lets return here to the question of borders and question the nature of this war we are fighting now, which UN Secretary-General Antnio Guterres considers the biggest challenge the UN has faced since the Second World War. The war against the virus is first of all an infowar. The enemy is invisible. It can only be located through information about communities and the mobility of individuals. The efficacy of the war depends on the ability to gather and analyze information and to mobilize available resources to achieve the highest efficiency. For countries exercising strict online censorship, it is possible to contain the virus like containing a sensitive keyword circulating on social media. The use of the term information in political contexts has often been equated with propaganda, though we should avoid simply seeing it as a question of mass media and journalism, or even freedom of speech. Infowar is twenty-first century warfare. It is not a specific type of war, but war in its permanence.

In his lectures collected in Society Must Be Defended, Michel Foucault inverted Carl von Clausewitzs aphorism war is the continuation of politics by other means into politics is the continuation of war by other means.15 While the inversion proposes that war no longer assumes the form Clausewitz had in mind, Foucault hadnt yet developed a discourse on infowar. More than twenty years ago, a book titled Wars without Limit (, officially translated as Unrestricted Warfare or Warfare beyond Bounds) was published in China by two former senior air force colonels. This book was soon translated into French, and is said to have influenced the Tiqqun collective and later the Invisible Committee. The two former colonelswho know Clausewitz well but havent read Foucaultarrived at the claim that traditional warfare would slowly fade away, to be replaced by immanent wars in the world, largely introduced and made possible by information technology. This book could be read as an analysis of the US global war strategy, but also more importantly as a penetrating analysis of how infowar redefines politics and geopolitics.

The war against coronavirus is at the same time a war of misinformation and disinformation, which characterizes post-truth politics. The virus may be a contingent event that triggered the present crisis, but the war itself is no longer contingent. Infowar also opens two other (to some extent pharmacological) possibilities: first, warfare that no longer takes the state as its unit of measure, instead constantly deterritorializing the state with invisible weapons and no clear boundaries; and second, civil war, which takes the form of competing infospheres. The war against coronavirus is a war against the carriers of the virus, and a war conducted using fake news, rumors, censorship, fake statistics, misinformation, etc. In parallel to the US using Silicon Valley technology to expand its infosphere and penetrate most of the earths population, China has also built one of the largest and most sophisticated infospheres in the world, with well-equipped firewalls consisting of both humans and machines, which has allowed it to contain the virus within a population of 1.4 billion. This infosphere is expanding thanks to the infrastructure of Chinas One Belt, One Road initiative, as well as its already established networks in Africa, causing the US to respond, in the name of security and intellectual property, by blocking Huawei from extending its infosphere. Of course, infowar is not waged only by sovereigns. Within China, different factions compete against each other through official media, traditional media such as newspapers, and independent media outlets. For instance, both the traditional media and independent media fact-checked state figures on the outbreak, forcing the government to redress their own mistakes and distribute more medical equipment to hospitals in Wuhan.

The coronavirus renders explicit the immanence of infowar through the nation-states necessity to defend its physical borders while extending technologically and economically beyond them to establish new borders. Infospheres are constructed by humans, and, in spite of having greatly expanded in recent decades, remain undetermined in their becoming. Insofar as the imagination of co-immunityas a possible communism or mutual aid between nationscan only be an abstract solidarity, it is vulnerable to cynicism, similar to the case of humanity. Recent decades have seen some philosophical discourses succeed in nurturing an abstract solidarity, which can turn into sect-based communities whose immunity is determined through agreement and disagreement. Abstract solidarity is appealing because it is abstract: as opposed to being concrete, the abstract is not grounded and has no locality; it can be transported anywhere and dwell anywhere. But abstract solidarity is a product of globalization, a meta-narrative (or even metaphysics) for something that has long since confronted its own end.

True co-immunity is not abstract solidarity, but rather departs from a concrete solidarity whose co-immunity should ground the next wave of globalization (if there is one). Since the start of this pandemic, there have been countless acts of true solidarity, where it matters greatly who will buy groceries for you if you are not able to go to the supermarket, or who will give you a mask when you need to visit the hospital, or who will offer respirators for saving lives, and so forth. There are also solidarities among medical communities that share information towards the development of vaccines. Gilbert Simondon distinguished between abstract and concrete through technical objects: abstract technical objects are mobile and detachable, like those embraced by the eighteenth-century encyclopedists that (to this day) inspire optimism about the possibility of progress; concrete technical objects are those that are grounded (perhaps literally) in both the human and natural worlds, acting as a mediator between the two. A cybernetic machine is more concrete than a mechanical clock, which is more concrete than a simple tool. Can we thus conceive of a concrete solidarity that circumvents the impasse of an immunology based in nation-states and abstract solidarity? Can we consider the infosphere to be an opportunity pointing towards such immunology?

We may need to enlarge the concept of the infosphere in two ways. First of all, the building of infospheres could be understood as an attempt to construct techno-diversity, to dismantle the mono-technological culture from within and escape its bad infinity. This diversification of technologies also implies a diversification of ways of life, forms of coexistence, economies, and so forth, since technology, insofar as it is cosmotechnics, embeds different relations with nonhumans and the larger cosmos.16 This techno-diversification does not imply an ethical framework imposed onto technology, for this always arrives too late and is often made to be violated. Without changing our technologies and our attitudes, we will only preserve biodiversity as an exceptional case without ensuring its sustainability. In other words, without techno-diversity, we cannot maintain biodiversity. The coronavirus is not natures revenge but the result of a mono-technological culture in which technology itself simultaneously loses its own ground and desires to become the ground of everything else. The mono-technologism we live now ignores the necessity of coexistence and continues to see the earth merely as a standing reserve. With the vicious competition it sustains, it will only continue to produce more catastrophes. According to this view, after the exhaustion and devastation of spaceship earth, we may only embark on the same exhaustion and devastation on spaceship Mars.

Secondly, the infosphere can be considered a concrete solidarity extending beyond borders, as an immunology that no longer takes as its point of departure the nation-state, with its international organizations that are effectively puppets of global powers. For such concrete solidarity to emerge, we need a techno-diversity which develops alternative technologies such as new social networks, collaborative tools, and infrastructures of digital institutions that will form the basis for global collaboration. Digital media already has a long social history, though few forms beyond that of Silicon Valley (and WeChat in China) assume a global scale. This is largely due to an inherited philosophical traditionwith its oppositions between nature and technology, and between culture and technologythat fails to see a plurality of technologies as realizable. Technophilia and technophobia become the symptoms of mono-technological culture. We are familiar with the development of hacker culture, free software, and open-source communities over the past few decades, yet the focus has been on developing alternatives to hegemonic technologies instead of building alternative modes of access, collaboration, and more importantly, epistemology.

The coronavirus incident will consequently accelerate processes of digitalization and subsumption by the data economy, since it has been the most effective tool available to counter the spread, as we have already seen in the recent turn in favor of using mobile data for tracing the outbreak in countries that otherwise cherish privacy. We may want to pause and ask whether this accelerating digitalization process can be taken as an opportunity, a kairos that underlines the current global crisis. The calls for a global response have put everyone in the same boat, and the goal of resuming normal life is not an adequate response. The coronavirus outbreak marks the first time in more than twenty years that online teaching has come to be offered by all university departments. There have been many reasons for the resistance to digital teaching, but most are minor and sometimes irrational (institutes dedicated to digital cultures may still find physical presence to be important for human resource management). Online teaching will not completely replace physical presence, but it does radically open up access to knowledge and return us to the question of education at a time when many universities are being defunded. Will the suspension of normal life by coronavirus allow us to change these habits? For example, can we take the coming months (and maybe years), when most universities in the world will use online teaching, as a chance to create serious digital institutions at an unprecedented scale? A global immunology demands such radical reconfigurations.

This essays opening quote is from Nietzsches incomplete Philosophy in the Tragic Age of the Greeks, written around 1873. Instead of alluding to his own exclusion from the discipline of philosophy, Nietzsche identified cultural reform with philosophers in ancient Greece who wanted to reconcile science and myth, rationality and passion. We are no longer in the tragic age, but in a time of catastrophes when neither tragist nor Daoist thinking alone can provide an escape. In view of the sickness of global culture, we have an urgent need for reforms driven by new thinking and new frameworks that will allow us to unbind ourselves from what philosophy has imposed and ignored. The coronavirus will destroy many institutions already threatened by digital technologies. It will also necessitate increasing surveillance and other immunological measures against the virus, as well as against terrorism and threats to national security. It is also a moment in which we will need stronger concrete, digital solidarities. A digital solidarity is not a call to use more Facebook, Twitter, or WeChat, but to get out of the vicious competition of mono-technological culture, to produce a techno-diversity through alternative technologies and their corresponding forms of life and ways of dwelling on the planet and in the cosmos. In our post-metaphysical world we may not need any metaphysical pandemics. We may not need a virus-oriented ontology either. What we really need is a concrete solidarity that allows differences and divergences before the falling of dusk.

I would like to thank Brian Kuan Wood and Pieter Lemmens for their comments and editorial suggestions on the drafts of the essay.

Yuk Hui currently teaches at the School of Creative Media, City University of Hong Kong, his latest book is Recursivity and Contingency (2019).

2020 e-flux and the author

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One Hundred Years of Crisis - Journal #108 April 2020 - E-Flux

Trinity to set up Covid-19 research centre – The Irish Times

Trinity College Dublin is to set up a Covid-19 research hub that will focus on the most urgent scientific breakthroughs needed to address the current pandemic including design of new drugs and a vaccine to combat the virus.

The hub will work with doctors from St Jamess Hospital, Dublin, other hospitals in Ireland, and established research partners around the world.

It will also work on development of rapid antibody testing capacity to identify current and previous Covid-19 infection in healthcare workers, and eventually the wider community.

This will be critical to determining if doctors and nurses can return to frontline services after infection by the virus, and to informing any easing of lockdown restrictions in the general population.

The problem of supply and validation of commercial antibody testing kits will also be on its research agenda, as numerous test kits coming on to global markets are proving to be inaccurate.

Prof Kingston Mills, who is co-leading the project, underlined the importance of investigating the immune response in infected and recovered Covid-19 patients to establish whether previous infection prevents reinfection, including serial sampling of patients at St Jamess Hospital and other collaborating hospitals.

The Covid-19 Research Hub will be located at Trinitys biomedical sciences institute, and led by immunologists there and infectious disease clinicians from St Jamess Hospital.

As foundation partner, AIB has committed 2.4 million to advance the project while the hub will continue to accept contributions from other public and private sources.

Prof Mills said the research would concentrate on the immune responses to the virus in infected and recovered patients. This will provide key information for the design of vaccines and immunotherapeutic drugs for controlling the often fatal inflammation in Covid-19 patients, and will assist in developing and validating new assays for detecting antibody responses to the virus, thereby identifying those who are immune and therefore safe to return to work.

According to AIB chief executive Colin Hunt: In the face of this unprecedented medical, societal and economic crisis, it is imperative that we mobilise all the resources at our disposal in a strategic way. We are investing in a national and international endeavour to save lives. Trinity ranks in the top 1 per cent of research institutions globally in medicine and biological sciences, and its immunologists collaborate with the best internationally.

The initiative will also involve the expertise of leading immunologist Prof Luke ONeill.

TCD provost Patrick Prendergast said the solution to the Covid-19 crisis would probably be found in university laboratories in the months ahead following collaboration between leading researchers across the globe.

Trinity is one of the worlds leading universities when it comes to research into immunology and immunity and has the research expertise to play a major role. Donations such as this are a generous, practical and timely contribution to the fight against this terrible virus, he said.

Prof Aideen Long, director of Trinitys translational medicine institute, is the other co-leader, while consultant immunologist Niall Conlon; consultant physician in infectious diseases Colm Bergin; professor of translational immunology Padraic Fallon; and consultant Clona N Cheallaigh will all play key roles.

The project will also benefit from Trinitys global network of collaborations and contacts in universities such as MIT in Boston and Utrecht University in the Netherlands, and with Public Health England, so knowledge is shared and breakthroughs on Covid-19 are as effective and swift as possible.

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Trinity to set up Covid-19 research centre - The Irish Times