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TWC Discourse: Why Humanity Failed to Prevent COVID-19 Pandemic Despite Knowing About Its Possibility – The Weather Channel

Migrant workers from other states stand in a crowded, congested queue to collect food ration handed by the Worli police personnel in Mumbai, Maharashtra.

Short-sightedness while surveilling for potentially threatening infections, and failure to maintain transparency at the beginning of the COVID-19 outbreak, led to humanitys failure in preventing the viral disease from becoming a pandemic, according to two world-renowned, leading virologists.

The Weather Channel, in a live session, spoke to Dr Bellur S Prabhakar, Professor of Microbiology and Immunology, and Senior Associate Dean for Research, University of Illinois College of Medicine, Chicago; and Dr Polly Roy, Professor of Virology in London School of Hygiene and Tropical Medicine, UK about everything related to past and future of novel coronavirus.

When asked if anyone had seen such a large-scale pandemic coming, Dr Prabhakar explained: In the scientific community, it is extremely well known that virus pandemics are inescapable, and are likely to occur periodically.

Therefore, the world at large is trying its best to conduct active surveillance, which involves constantly looking out for potential infectious agents that can create global calamities like the one we are seeing right now.

Unfortunately, the governments are somewhat short-sighted, and they dont always invest sufficient time, energy, and financial resources to keep this active surveillance effective and uninterrupted. And when you fail to maintain active surveillance, infections can creep up on you, and suddenly get out of control. Thats what happened in the ongoing pandemic.

Dr Prabhakar has a broad experience in virology, immunology, and public health, and has been extensively working on autoimmune diseases for over 30 years.

Along with the lack of surveillance to detect the infection, the lack of transparency at the beginning of the COVID-19 outbreak, and the failure to distribute information on the virus widely and immediately also cost us dearly in the fight against this pandemic, adds Dr. Dr. Polly Roy.

Not getting the information very quickly cost us this time. Had we known from the beginning about the possibility of human-to-human transmission, then we would have taken apt precautions from the beginning, she said.

Recognising her contributions to virology research, Dr Roy has been conferred multiple awards and recognition, including the Indian Science Congress General President's Gold Medal, awarded by the Prime Minister of India and an Officer of the Order of the British Empire award, presented by the Queen. She is even involved with the development of vaccine for COVID-19, which can be a reality within next 12 to 18 months.

Both experts, however, remain optimistic about the future! If we learn from our past experiences, become more transparent about information, improve funding for research on infectious diseases, and make huge investments in public health systems worldwide, humanity will collectively become more equipped to successfully tackle such pandemics in the future, they conclude.

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TWC Discourse: Why Humanity Failed to Prevent COVID-19 Pandemic Despite Knowing About Its Possibility - The Weather Channel

Switzerland to Launch First COVID-19 Vaccine in August – Immunology Expert – UrduPoint News

GENEVA (UrduPoint News / Sputnik - 20th April, 2020) Swiss immunologists will be ready to start vaccinating people against COVID-19 domestically as early as August, Martin Bachmann, the head of the immunology chair at Bern University, said on Monday.

Bachmann is currently leading a group of experts from several Swiss universities for developing a so-called genetically synthesized vaccine based on virus-like particles. Such vaccines - in use for Hepatitis B, for example - work by breaking down the protein which the virus uses to attach to a cell.

"We plan to immunize first people in August and then to conduct a large vaccination in October," Bachmann said at a press conference with the Association of Foreign Correspondents at the UN Office in Geneva.

According to the expert, the novel coronavirus is genetically stable and, unlike influenza, is most likely to not require more than one vaccine in a relatively long period of time.

"Our strategy is to achieve the immunization of at least all of Switzerland's population within the next six months and then begin producing the vaccine for the global market. This is an ambitious goal, but I assure you we have good chances," Bachmann said.

The team of experts expects to distinguish the most effective working samples of the vaccines by the end of April for them to then be tested in the Zurich and Bern university hospitals.

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Switzerland to Launch First COVID-19 Vaccine in August - Immunology Expert - UrduPoint News

John Leyba named dean of the College of Science and Mathematics – News at UNG

Dr. John Leyba has been named the new dean of the College of Science & Mathematics at the University of North Georgia (UNG).

Leyba has served as interim dean for the past year and had been associate dean of the College of Science and Mathematics at UNG since 2018. Before that, Leyba was the head of the Department of Chemistry & Biochemistry. He was hired for the job in August 2014 after working for Newman University in Wichita, Kansas, for 12 years and subcontractors for the U.S. Department of Energy (DOE) for more than 11 years.

"During my time as interim, it was surreal. But I got a good feel for the job and I enjoyed doing it," the father of eight children said. "So when UNG posted the job, it hit home that I had to apply."

After a national search, Leyba was hired and will become official on May 1.

"We felt it was important to conduct a national search to identify the next dean for the College of Science & Math," said Dr. Chaudron Gille, provost and senior vice president of Academic Affairs. "Dr. Leyba brings a wealth of experience in industry as well as years of academic leadership to the position.He was clearly the most qualified candidate and was unanimously endorsed by the committee."

Leyba earned his Bachelor of Science degree in chemistry from Northeast Missouri State University, now called Truman State University, in 1986. Four years later, he received his doctoral degree in nuclear chemistry from the University of California, Berkeley.

As the new dean, Leyba has set his sights on completing current goals and establishing new ones.

Some of the current projects Leyba established were the electronic newsletter called "Momentum" and the College of Science & Mathematics Facebook and Instagram pages. The newsletter is sent to stakeholders and supporters to showcase the college's efforts. The two social media platforms are used to inform students and alumni about the college's activities.

"Scientists are not the best communicators," Leyba said. "We need to blow our own horn about what we are doing and accomplishing here."

Leyba also anticipates the completion of the new North Georgia Astronomical Observatory near UNG's Dahlonega Campus as well as the creation of a small observatory on the Gainesville Campus. He is also anticipating the completion of the new greenhouse in Gainesville. Both the North Georgia Astronomical Observatory and Gainesville greenhouse were part of the College of Science & Mathematics' strategic plan that Leyba helped author and looks forward to implementing.

"The strategic plan got everyone on the same page with a common set of goals," he said. "An important part was the inclusivity of all campuses. It had an important milestone for each campus. No campus is more important than another. As a team we will move forward and achieve those goals."

To do that, Leyba plans to continue a tradition he learned from a boss in the private sector. Early in his career, Leyba worked for the DOE's Savannah River Site in Aiken, South Carolina, and the Rocky Flats Site in Colorado.

"Every Friday, my first boss would walk the halls. He'd come into your office and talk to you about anything," Leyba said. "That's what I would like to do. I want to show up on any campus unannounced and walk the halls."

There he wants to acquaint himself with all of the faculty and staff and learn their personalities, interests and ambitions. He also wants to determine the needs of each campus.

"Each one has its own strengths and challenges. They can tailor their courses to the campus and students' needs," he said. "As a manager, I want to enable people to do their jobs better."

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John Leyba named dean of the College of Science and Mathematics - News at UNG

Turning On the ‘Off Switch’ in Cancer Cells – Michigan Medicine

We used cryo-electron microscopy to obtain three-dimensional images of our tool-molecule, DT-061, bound to PP2A, says study co-senior author Derek Taylor, Ph.D., an associate professor of pharmacology and biochemistry at Case Western Reserve University and member of the Case Comprehensive Cancer Center. This allowed us to see for the first time precisely how different parts of the protein were brought together and stabilized by the compound. We can now use that information to start developing compounds that could achieve the desired profile, specificity and potency to potentially translate to the clinic.

The researchers propose calling this class of molecules SMAPs for small molecule activators of PP2A.

Along with cancer, PP2A is also dysregulated in a number of other diseases including cardiovascular and neurodegenerative diseases. And the researchers are optimistic the findings could also open opportunities to develop new medicines against diseases like heart failure and Alzheimers as well.

The research required a marriage of scientific disciplines and areas of expertise, notes co-senior author Goutham Narla, M.D., Ph.D., chief of the division of genetic medicine in the department of internal medicine at the U-M Medical School.

Its an illustration of how collaboration and team science can solve some of the questions like this that scientists have been asking for many years, Narla says. Solving the structure without the biological knowledge of how best to apply it against cancer, would only be half of the story. And if we were just activating PP2A, killing cancer cells and slowing the growth of cancer without the structural data that would be a really nice half-story as well. But working together, we now have a story about being able to drug this previously undruggable tumor suppressor.

The study was led by first authors Daniel Leonard, an M.D. and Ph.D. student and member of Narlas lab when the research was at Case Western Reserve and the Case Comprehensive Cancer Center, and research scientist Wei Huang, Ph.D., of the Taylor lab.

There has been a lot of activity and excitement in recent years around the development of kinase inhibitors small molecule compounds that go after the protein kinases whose dysfunction is involved in the explosive growth and proliferation of cancer cells. That is, turning off cancers on switch, Leonard explains.

The new research attacks cancer from the opposite side of the equation, turning on cancers off switch by stabilizing protein phosphatases whose malfunction removes a key brake on cancer growth.

In the paper, the researchers speculate how a combination of both approaches simultaneously might offer an even more powerful one-two punch potentially helping to overcome cancers ability to evolve to thwart a singular approach.

The binding pocket we identified provides a launch pad for optimizing the next generation of SMAPs toward use in the clinic in cancer, and potentially other diseases, Huang adds.

Additional authors include Danica D. Wiredja, Yinghua Chen, Daniela M. Schlatzer, Janna Kiselar, Nikhil Vasireddi and Abbey L. Perl of Case Western Reserve University; Sudeh Izadmehr, Nilesh Zaware and Matthew D. Galsky of the Icahn School of Medicine at Mount Sinai; Caitlin M. OConnor of the University of Michigan; Zhizhi Wang and Wenqing Xu of the University of Washington; David L. Brautigan of the University of Virginia; and Stefan Schchner and Egon Ogris of the Medical University of Vienna.

The research was supported by grants from the National Institutes of Health (R01 CA240993, R01 GM133841, R01 CA181654, F30 TRN216393, T32 GM007250), and an American Heart Association Postdoctoral Fellowship (17POST33650070).

DT-061 was developed at the Icahn School of Medicine at Mount Sinai, which has filed for patent protection on the tool compound. Narla, Ogris and Taylor have ownership interest in RAPPTA Therapeutics, which has licensed the cryo-EM coordinates for the clinical and commercial development of novel series of small molecule PP2A activators from the University of Michigan and Case Western Reserve; the authors and institutions stand to benefit financially. The Medical University of Vienna has filed a patent on a monoclonal antibody used in the study.

Paper cited: Selective PP2A Enhancement Through Biased Heterotrimer Stabilization, Cell. DOI: 10.1016/j.cell.2020.03.038

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Turning On the 'Off Switch' in Cancer Cells - Michigan Medicine

News updates from Hindustan Times: Arvind Kejriwal on why lockdown rules won’t be relaxed in Delhi and all the latest news – Hindustan Times

Here are todays top news, analysis and opinion. Know all about the latest news and other news updates from Hindustan Times.

77 containment zones, 1893 Covid-19 cases: Arvind Kejriwal on why lockdown rules wont be relaxed in Delhi

Delhi chief minister Arvind Kejriwal on Sunday gave a number of reasons why there wont be any relaxation in the rules during the lockdown till May 3 in the national capital. The Aam Aadmi Party (AAP) chief said he will hold a review meeting after a week on April 27 to review the situation. Read more

Haridwar, Nainital districts in Uttarakhand classified as red zones after spike in Covid-19 cases

Authorities in Uttarakhand have designated Haridwar and Nainital as red zones or hotspots after a spike in the number of coronavirus disease (Covid-19) cases in these two districts, news agency ANI reported on Sunday. Read more

Manipurs 2nd Covid-19 patient tests negative two weeks after treatment

Manipurs second Covid-19 patient has tested negative for the first time since undergoing treatment, according to official sources. The northeastern state has reported only two cases of coronavirus infection, according to the latest health ministry figures. Read more

Maharashtra dedicates 25 more hospitals to treat Covid-19 patients

No new cases of Covid-19 were recorded on Sunday morning in Maharashtra as the tally of Covid-19 cases has remained 3,648 cases and 211 deaths, state health department officials said. Read more

Schools, shops re-open across Europe as Covid-19 cases plateau, but experts warn caution

People reading in downtown Rome, children going to elementary schools in Demark, Italians returning to bookstores and Austria allowing gardening stores to sell flowers again - life seems to return to normalcy as an initial sign of hope and optimism that the first wave of Europes devastating pandemic is coming to an end. Read more

He may win 6-7 titles: Gautam Gambhir names his pick for best IPL captain

Former India cricketer Gautam Gambhir on Saturday picked Mumbai Indians skipper Rohit Sharma as the best captain of the Indian Premier League. Under his leadership, MI have become the most successful franchise of IPL with four trophies in 12 seasons. Read more

Chris Hemsworth chickens out of insane Extraction action sequence, leaves it to experts. Watch video

Chris Hemsworth may play the god of thunder, Thor, in the Marvel Cinematic Universe but the actor sure knows when to step up and when to back down with flexed biceps and folded hands. Read more

Word of the Week:Is time really up for the apostrophe?

The closing of the Apostrophe Protection Society because of the ignorance and laziness of the general public strikes a body blow against those fighting for correct English. Read more

Covid-19 to be part of syllabus of Biochemistry at Lucknow University

The decision was made in agreement with the teachers of the biochemistry department who are now busy in preparing a syllabus accordingly. The final syllabus, along with the proposal will be put forward in the next executive council meeting of the university. Read more

Woman tries to show perfect handstand but her dog has other plans. Watch

A video of a woman heading for that perfect handstand would have been amazing and even somewhat motivating until a dog decided to walk in the scene and foil the attempt at fakery. Read more

Watch| US now expects up to 65,000 deaths from Covid-19: President Donald Trump

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News updates from Hindustan Times: Arvind Kejriwal on why lockdown rules won't be relaxed in Delhi and all the latest news - Hindustan Times

ELITechGroup MDx LLC and OSANG Healthcare Join Fight Against COVID-19 in the United States Providing FDA Emergency Use Authorization Rapid Detection…

BOTHELL, Wash., April 20, 2020 /PRNewswire/ --ELITechGroup MDx LLC, a leading global provider of diagnostic testing products, and its Korean partner, OSANG Healthcare, announced today that the U.S. Food and Drug Administration (FDA) has issued Emergency Use Authorization (EUA) for its SARS-CoV-2 virus test for use in the United States.

The GeneFinderTM COVID-19 Plus RealAmp Kit provides a fast and easy-to-use diagnostic solution to rapidly identify clusters of infection and has been validated using the ABI 7500 thermocycler and Bio-Rad CFX96 cycler both popular Polymerase Chain Reaction(PCR) instruments found in diagnostics laboratories throughout the country.

Delivering qualitative results within hours, the highly sensitive testing kit requires a single tube rather than multiple reactions and uses Aveolar fluid, throat swab or sputum samples in a PCR instrument to detect the virus.

"The dramatic explosion of the novel coronavirus is affecting lives in every state," said ELITechGroup CEO, Christoph Gauer. "Hospitals and labs need access to reliable COVID-19 test kits, and we are here to support the medical professionals on the front lines working to prevent the spread of COVID-19."

To date, ELITechGroup has delivered more than 700,000 COVID-19 CE-IVD tests worldwide that have proven effective in accurately detecting the infection. ELITechGroup MDx is the exclusive distributor of the test kits to certain markets across the United States.

"We are determined to fight COVID-19 and the alarming infection rates now being seen in the U.S.," said OSANG Healthcare Chairman Dong-Hyun Lee. "We are pleased to partner with ELITechGroup MDx to bring much needed testing kits to U.S. shores."

To learn more or to order the COVID-19 Detection Kit for your lab or hospital, call 800-453-2725 or email at MDxSales@elitechgroup.com.

For more information about ELITechGroup MDx in the Unites States, please visit ELITechGroup.com/North-America/.

About ELITechGroup MDx LLC: ELITechGroup is a privately held group of worldwide manufacturers and distributors of in vitro diagnostic equipment and reagents. By bringing together IVD specialty companies that offer innovative products and solutions, ELITechGroup has become a major contributor in advancing clinical diagnostics to laboratories in the proximity market, those operating closer to the patient.

About OSANG Healthcare:OSANG Healthcare is a manufacturer of IVD (In-Vitro Diagnostics) Medical Devices of multiple fields ranging from Biochemistry, Immunoassay, and Molecular Diagnostics distributing globally to 100+ countries for over 23 years. By utilizing our in house innovation, OSANG Healthcare is dedicated to providing the most accurate, affordable, and real-time results at Point-of-Care (POC).

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ELITechGroup MDx LLC and OSANG Healthcare Join Fight Against COVID-19 in the United States Providing FDA Emergency Use Authorization Rapid Detection...

Virtual Dance Marathon 2020 highlights intersection of HIV/AIDS and COVID-19 – Daily Bruin

Dance Marathon brought participants together in a time when everyone is meant to be apart.

The event, which took place Saturday on Zoom, united over 300 dancers on the virtual platform for four hours. Balancing educational content with bursts of upbeat activities like a drag performance, the annual event preserved its aim to illuminate the stories of those affected by HIV/AIDS and bring awareness to the cause. The Pediatric AIDS Coalition at UCLA, which hosts the event, hoped to highlight the commonalities of HIV/AIDS and COVID-19 by showing how these conditions are exacerbated by each other, said PAC president and fourth-year neuroscience and Spanish student Sophie Ahmad.

We want to talk about how it intersects with COVID-19 just because they are similar in their history, the stigma surrounding people and the fear that broke out when this unknown infection was spreading around, Ahmad said.

The gathering began with opening statements from Ahmad detailing Dance Marathons goal of defeating the stigma against HIV/AIDS. Decked in PACs bright yellow Unite T-shirt, the organizations president introduced the a cappella group Medleys A Cappella to sing the national anthem. Then, with a screen split into a multitude of windows, viewers could see each of the singers faces as they sang a rendition of John Lennons Imagine.

Transitioning from song to dance, PACs leadership urged the audience to join them in the 2020 morale dance, traditionally taught at the beginning of every Dance Marathon. This years morale dance drew inspiration from daily life in quarantine, with moves inspired by mundane tasks like washing your feet or taking cereal off the shelf. Accentuated by quick shoulder shimmies and hip twirls, the morale dance was set to Diana Rosss disco classic Im Coming Out and was repeated three times throughout the event.

After the morale dance portion, PACs leaders introduced the team captains and their colors ranging from a tie-dyed orange shirt to green gym shorts followed by speaker Ben Banks and his experience with pediatric HIV/AIDS. After Banks story concluded, the cause education committee gave an educational presentation touching upon HIV/AIDS myths and the effects its stigma leaves upon those with it. One member of the committee, second-year microbiology, immunology and molecular genetics student Sam Joslyn, discussed the impact of stigma in relation to the ongoing COVID-19 crisis, including the physical assault of an Asian man in London.

The effect of this stigma is in all aspects of life, Joslyn said. Theres been a rise in verbal and physical hate crimes all around the world, and this type of scapegoating has a long history.

After taking questions about the presentation from the audience, the event transitioned into a performance by drag queen Lorelai. Strutting to Billie Eilishs bad guy in a skintight velvet suit and coiffed mustache, Lorelai used the online platform to her advantage by utilizing a split-screen to project two versions of herself at once. Once the drag queen walked off the screen, PAC leaders facilitated the morale dance once again before beginning the events vigil to honor those with HIV/AIDS.

During the vigil, several UCLA-affiliated musicians performed, including Izzy Escobar, Mad, Akshay Anand, Shivan, Dark Dazey and Taxi. Escobar, lit by a hazy pink rose projected onto her, performed a song of hope that described how the light always comes when you stop looking.

Mad followed with a stripped-down ukulele song about the idealism of youth and teenage cliches, while Anand sang maybe Ive been alone too long, drawing attention to the looming uncertainty of the current climate. Later, former Spring Sing contestants Dark Dazey and Taxi lightened the mood with upbeat, rock-infused dance tracks, while Shivan looped his guitar for a Michael Jackson cover.

Interspersed between musical performances, representatives from beneficiaries like Camp Laurel spoke about their experiences with HIV/AIDS. Alumna Kelly Gluckman discussed her experience contracting the virus from her boyfriend, touching upon the utility of poetry and creative writing as an outlet to express her feelings. Others spoke about their experiences at Camp Laurel as counselors finding a sense of community for the first time.

After the live speakers concluded, Appurva Goel, PACs executive director of outreach and fourth-year economics and communication student, asked the participants to join another bout of random dancing before announcing how much had been fundraised. The grand total was $143,288.59 and served as a representation of the communitys dedication to bringing awareness to HIV/AIDS, particularly in the uncertainty of todays climate, Goel said.

A movement is not constructed of figures and facts, but people willing to take a stand against injustice and suffering, Goel said.

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Virtual Dance Marathon 2020 highlights intersection of HIV/AIDS and COVID-19 - Daily Bruin

Nearly two-thirds of students enrolled in four courses – The Dartmouth

by Andrew Sasser | 4/20/20 2:30am

With the transition to remote learning and credit/no credit grading for the spring term, 63 percent of students are taking four courses rather than three this term, according to a survey conducted by The Dartmouth.

In an email to The Dartmouth, College registrar Meredith Braz confirmed that more students than usual are currently enrolled in four courses. She added that students can drop courses until May 11 and withdraw from courses until May 20, so specific numbers are likely to change.

By class year, just 33 percent of survey respondents in the Class of 2020 indicated that they were taking four classes this term, compared to an average of 72 percent across juniors, sophomores and freshmen. A total of almost 570 people responded to the survey between April 14 and 18.

In a survey question asking whether the circumstances including credit/no credit, remote classes and personal or family situation of COVID-19 affected course selection, 41 percent said that they chose to take more classes due to the terms circumstances, while 17 percent said that the changes to term had no impact on their course selection. Additionally, nine percent said that at least one of their classes was canceled due to COVID-19 circumstances.

Grace Lu 23 said that she chose to take four courses to further explore her academic interests. She said that she chose to take an extra course because she thought that she was going to be bored at home, and she also wanted to use the time to figure out what she wants to major in.

I was thinking about majoring in cognitive science, neuroscience or psychology, Lu said. I decided to add on a psychology course this term so I can figure out what Im interested in, maybe even by the end of the term.

Twenty-five percent of survey respondents said that due to the terms format, they enrolled in more difficult courses. Anahita Kodali 23 said that because classes this term are being graded on a credit/no credit scale, she decided to take ECON 1, The Price System: Analysis, Problems and Policies a class that she said would have otherwise killed her grade point average.

Student opinions varied when surveyed about the difficulty of their classes this term: 40 percent of students indicated that their classes this term required the same amount of effort compared to an on-campus term, while 33 percent indicated that they required more effort and 27 percent indicated that their courses required less effort.

Some students have found their workloads to require a larger time commitment. Nicole Evans 22, who is taking four classes, said that despite the transition to remote learning, all of her classes are very time-consuming.

Even for pass/fail, it almost feels like my classes are more work, Evans said, adding that [i]ts been a little hard to find motivation when Im at home.

Additionally, some students had to adjust their course schedule due to class cancellations. Nik Morgan 23 said that she struggled to find classes that interested her after a class that she had originally planned to take, HIST 8.01, Body Parts, Body Wholes: An Introduction to the Comparative History of Medicine, was canceled.

Since add/drop crashed and every class filled up, I am stuck in classes I did not want to take, Morgan said. I was boxed out of being able to fulfill major prerequisites.

In response to student demand, some classes expanded their enrollment caps this term. Computer science professor Devin Balkcom said that his COSC 1, Introduction to Programming and Computation course expanded its enrollment cap from 190 to 300 students in light of the transition to remote learning. Balkcom added that in response to increased enrollment, he also increased the number of student section leaders in his class.

Because the term is so unusual, I wanted to reduce the ratio of section leaders to students, so we now have 60 section leaders, Balkcom said. Its an army to organize, but this way we can maintain the same degree of hands-on help like in a normal term.

Similarly, biological sciences department chair Thomas Jack said that a number of courses in the biology department saw their enrollments go up fairly dramatically.

Jack said that most courses especially introduction and intermediate level courses removed or increased enrollment caps. Some upper-level seminar courses chose to maintain caps because professors felt [size] was important with how they taught their courses.

In contrast, economics department chair Nina Pavcnik said that most economics courses maintained their enrollment caps in spite of increased demand. She said that while additional students wanted to enroll in economics courses after credit/no credit grading was announced, the department was not willing to increase most enrollment caps, as they wanted to maintain the same level of interaction between faculty and students.

From April 14 to April 18, The Dartmouth fielded an online survey of Dartmouth undergraduate students asking about their course-load for the spring term. The survey was sent out to 4655 students through their Dartmouth email addresses. Five hundred and sixty nine responses were recorded, resulting in an 12.2 percent response rate with a margin of error of +/- 3.8 percentage points. Using administrative data from the Colleges Office of Institutional Research, responses were weighted by race/ethnicity, gender and graduation year. Weighting was done through iterative post-stratification (raking).

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Nearly two-thirds of students enrolled in four courses - The Dartmouth

Testicles Might Be Making Men More Vulnerable To Coronavirus: Study – SheThePeople

More men are dying of coronavirus than women. Why? A new study shows that the presence of testicles in men makes them more vulnerable to longer and more severe cases COVID-19. The collaborative study was conducted by the Department of Oncology, Cell Biology, and Epidemiology and Population Health, Montefiore Medical Center & Albert Einstein College of Medicine, Bronx, NY, andDepartment of Microbiology, Topiwala National Medical College & BYL Nair Hospital, Kasturba Hospital for Infectious Diseases, Mumbai, India.

About the study:

Also Read:Corona Warriors: Odisha Woman Farmer Distributes Her Produce

Why Testicles Make Men More Vulnerable To COVID-19?

The novel coronavirus has been specifically found to be more fatal for men than women. This, according to a new study is because of the host factors. The study included 68 subjects in total, with 48 men and 20 women. There were two important observations made by the researchers

Elucidating the above two observations, viral clearance is defined as the removal of viral contamination using specialized membranes (mostly proteins) or chromatography. Also, for a virus to enter its host, it needs an entry point. This entry point is called a virus receptor. In SARS-COV2, ACE2 is the receptor. The virus enters the host through a complex process but begins with the interaction of the viral surface spike protein with ACE2. ACE2 is a plasma membrane-bound monocarboxypeptidase that converts angiotensin II to angiotensin 1-7 (Ang 1-7), which antagonizes the hypertensive effects of Angiotensin I via stimulation of the MAS receptor. The study examined patterns in patients who were symptomatic and tested positive for coronavirus.

In both men and women, these ACE2 proteins, or receptors, are plentiful in the lungs, the gastrointestinal tract and the heart. Hence, these sites are the most vulnerable ones. However, the observations showed thatthe testicles were one of the sites with the highest ACE2 expression in 3 independent RNA expression databases (Human Protein Atlas, FAMTOM5 and GETx). Moreover, very little expression of the receptor was seen in the ovarian tissue, citing a possibility, why lesser women are dying of the COVID-19 than men.

Also Read:Domestic Violence Perpetrators in Pune to be in Institutional

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Testicles Might Be Making Men More Vulnerable To Coronavirus: Study - SheThePeople