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CZI announces grants for researchers studying the role of inflammation in disease – News-Medical.Net

Reviewed by Emily Henderson, B.Sc.Apr 29 2020

Today, the Chan Zuckerberg Initiative (CZI) announced $14 million in funding to support 29 interdisciplinary teams and build a network of researchers that will explore emerging ideas regarding the role of inflammation in disease. While inflammation is a natural defense that helps our bodies maintain a healthy state, chronic inflammation results in harmful diseases such as asthma, arthritis, and heart disease.

In this cohort, we welcome 80 researchers working on the projects, 75 percent of which are led by early-career scientists within six years of starting their independent position. Grantee teams are made up of two to three investigators with distinct areas of expertise, including physicians, experimental biologists, technology developers, and computational scientists. The awarded project teams represent 11 countries. View the full list of grantees.

Knowing more about inflammation at the level of affected cells and tissues will increase our understanding of many diseases and improve our ability to cure, prevent, or manage them. We look forward to collaborating with these interdisciplinary teams of researchers studying inflammation."

Cori Bargmann, CZI Head of Science

CZI will support these small teams to carry out two-year pilot projects focused on tissue-level inflammatory processes in diverse tissues and disease states. Several researchers are studying coronaviruses like SARS and MERS. Pilot awards are intended to help new collaborations form, establish technologies and experimental methods, and frame key questions for further investigation.

"Work on inflammation has been distributed among many fields and lacks dedicated support as a coherent discipline," said CZI Science Program Officer, Jonah Cool. "As these research teams study the cells involved in inflammation -- and the molecular mechanisms that link them -- we hope to support community growth and connect advances in inflammation that will have far-reaching impact."

Inflammation plays a role in organ failure, neurodegenerative diseases like Alzheimer's, and severe infectious diseases like COVID-19. Diseases associated with inflammation disproportionately affect underserved communities and vulnerable populations, highlighting the importance of making progress in this area of biology. Several funded projects will directly explore important differences depending on genetic ancestry and lifestyle.

These grants build on CZI's work in single-cell biology supporting the Human Cell Atlas, a fundamental reference for health and disease. Inflammation grantees are encouraged to think broadly about how collaboration and new technologies can be used to bring clarity to a question that touches so many diseases.

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CZI announces grants for researchers studying the role of inflammation in disease - News-Medical.Net

UVa researchers hope better understanding of spinal cord cells will aid treatment – The Daily Progress

University of Virginia scientists are exploring why nerve cells die after spinal cord injuries research that they hope could improve treatments.

Jonathan Kipnis, and Kodi Ravichandran, professors at the UVa School of Medicine, have received $350,00 from the Chan Zuckerberg Initiative in support of their research, the university announced.

Using a probe developed by Ravichandran, the two researchers are planning to track nerve cells after they die and are swallowed up by immune cells, or phagocytes, that remove them from the body. They want to see what type of cells are involved in the bodys response to a spinal cord injury and how they work.

Knowing what cell type is the phagocyte at the site of damage would allow us to specifically target that cell type or subtype of cells to eat more of the cellular debris after the brain or spinal cord injury, said Ravichandran, chairman of the Department of Microbiology, Immunology and Cancer Biology, in a news release.

The pairs funding is part of a $14 million effort from the institute for 29 interdisciplinary teams to explore the role of inflammation in various diseases.

Kipnis said in a news release Ravichandrans expertise in phagocytes complements his work as director of UVas Brain Immunology and Glia Center.

Merging complementary expertise and focusing on one common goal could lead to a real scientific breakthrough, said Kipnis, chairman of the Department of Neuroscience and director of UVAs Brain Immunology and Glia Center.

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UVa researchers hope better understanding of spinal cord cells will aid treatment - The Daily Progress

Editorial: Like it or not, we helped the virus find us – The Columbus Dispatch

This editorial represents the opinion of the Dispatch editorial board, which includes the publisher, editor, editorial page editor and editorial writers. Editorials, like opinion columns, represent a particular viewpoint and are not to be confused with news stories.

Thinking about how interconnected the natural world is how our every action can have consequences we never dreamed of can be uncomfortable.

Environment and biology researchers around the world are separately confirming a doozy of an example: Our fondness for a nice cut of beef helped unleash the viral pandemic that is ravaging the globe and its likely to cause more.

The chain involves several links, but it isnt mysterious: Production of beef cattle and the grains to feed them uses up way more land and water and produces way more carbon than just about anything else we could eat. That hastens climate change, which is rendering more of the world too hot or wet to support crops.

That forces people in developing nations to move farther into forests and jungles, destroying habitat for various animals and plants.

Once you have a rainforest chopped up into fragments, you get encounters between people and animals that would not otherwise bump into each other. Sometimes the people are in search of the same foods the animals like to eat. Sometimes the animals venture onto the humans fields in pursuit of those tasty crops.

Heres the critical link: Disturbed, changing habitats are especially good for weedy species such as bats and rats, which happen to be really good at hosting viruses. Often theyve infected other wildlife with those viruses. So when those human/animal encounters lead to a bite or a scratch or making a meal of the animal, a virus that has never before been in humans can jump to a human host, kicking off an outbreak against which humans have no immunity, vaccine or even experience.

Hence the emergence of SARS-CoV-2, the virus that has sickened 3.1 million people and killed 218,000 across the globe since December. Scientists still are studying its exact origin, but believe it found its first human at a wet market in Wuhan, China, possibly via a pangolin that was bitten by a bat.

The newest study to address this came from Stanford University last month. Researcher Laura Bloomfield studied people carving out farms at the edge of Ugandas Kibale National Park and found that those searching the fragmented forest edges for building materials were most likely to have contact with wild primates, known carriers of disease.

Scientists believe a primate was the source from which HIV, the virus that causes AIDs, found its first human. The Ebola virus is transmitted by various bat species and might have originated with one. In all cases, humans were venturing farther into wilderness areas.

It doesnt take a science denier to shrink from hearing this. Most Americans are used to eating plenty of meat, driving every day, turning up the A/C when its hot and other perks of our prosperity. We dont feel were immoral for enjoying these things.

But that doesnt change the effect that these behaviors, so familiar and innocuous to us, have on the larger world.

Some environmental activists lament the fact that the COVID-19 pandemic has distracted public attention from the urgent need to counter climate change, but the two arent entirely separate problems.

Human behavior consuming resources and producing waste has an impact that cannot be denied. Changing our behavior, particularly as the richest-living society on earth, is hard. Perhaps the frightening power of the coronavirus pandemic can make more people consider that change is necessary.

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Editorial: Like it or not, we helped the virus find us - The Columbus Dispatch

Get outside, but respect the natural world – Opinion – Cape Cod Times

A couple of years ago, during the longest government shutdown in American history, the caretakers of numerous national parks reported an uptick in vandalism and other careless human behavior, with people trampling over restricted areas, killing wildlife, littering, dumping trash and damaging natural habitats. Now, in the midst of a national emergency that has largely brought the country to a halt, more people are rediscovering the great outdoors, taking the time to enjoy visits to natural resources and to get out into nature. All of this is good, as it fosters a deeper connection with the world around us and reminds us that we are all closely linked to the environment. At the same time, it is crucial that, even as we enjoy and embrace the world of which we are an inextricable part, we do not directly or indirectly damage it.

Such is the problem at the Cape Cod National Seashore. A popular destination for decades, the Seashore routinely attracts between 3 million and 4 million visitors every year, and as in past springs, the warmer weather has brought a corresponding rise in the number of people visiting the park.

This spring, however, is proving to be like no spring in recent memory, and Park Service personnel are living with what appears to be one of the unforeseen consequences of the COVID-19 outbreak; that is, a rise in a variety of illegal activities, including dumping and vandalism on the Seashore grounds, as well as the more pedestrian problems of a spike in the number of dogs being walked off leash as well as the number of ATVs, which are banned from the Seashores many trails.

In an interview with Deputy Chief Ranger Ryan White, Cape Cod Times reporter Denise Coffey discovered that although many of these types of incidents are traditional problems for the Seashore, there has been a rise in the number of incidents in recent weeks. White spoke about instances where household trash was dumped at Wellfleets Great Island and construction debris was left at Easthams Doane Rock area.

The problem is not simply one of people leaving a mess for others to clean up, although that is in and of itself bad enough; this carelessness can also negatively affect the endangered wildlife that calls the Seashore home. White pointed specifically to terns and piping plovers, both of which are beginning to nest.

The issue here is not with the vast majority of visitors who come to the National Seashore and use the resources respectfully, follow the rules, and cart out all of the trash they produce. No, the problem is with the few who have decided that because the parks lands are extensive and that all of the public buildings are closed, this somehow grants them license to treat this precious jewel with neglect and selfishness, using it as both their trash can and their personal park.

Compounding the issue is the fact that many people are home with additional time on their hands. White said he believes this may have led to a surge in the number of home remodeling projects, and a consequential increase in the amount of trash produced. Also adding to the problem is the fact that as the number of coronavirus cases continued to grow, some towns temporarily shut down their building waste disposal areas to protect their employees, leaving homeowners and builders with the dilemma of what to do with their construction debris.

Given that the states order closing nonessential services remains in place, and the fact that the number of COVID-19 cases in the commonwealth continues to grow, there is little certainty as to when the Seashore shutdown might be lifted. Even in times without a global pandemic going on, park officials could not hope to fully monitor the more than 43,600 acres that make up the Seashore.

Now, perhaps more than ever before, it is up to all park visitors to help monitor the grounds, keeping an eye out for those who have decided to not follow the rules, and, where appropriate, perhaps reminding them that the Cape Cod National Seashore belongs to everyone. In times where discretion may be more appropriate than confrontation, informing Seashore personnel about a problem will go a long way toward helping preserve this unique treasure.

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Get outside, but respect the natural world - Opinion - Cape Cod Times

Game theory and COVID-19: Major defense project pivots to explore how to coordinate safe behavior – University of Michigan News

ANN ARBORShedding light on how officials at different levels of government can work together to maximize COVID-safe behavior is a new goal of a multiscale game theory project funded with $6.5 million from the Department of Defense.

Mingyan Liu

Mingyan Liu, leader of the project and the Peter and Evelyn Fuss Chair of Electrical and Computer Engineering, presented her teams work at a recent Call to Arms virtual conference, held by the National Science Foundations Networking Technology Systems group.

When human behavior is competitive, we dont use resources in the way that is most efficient for the communityas seen in behaviors like mask, sanitizer and toilet paper hoarding. But most of our decisions about how to behave arent entirely individualistic. We make them as part of a community. We are swayed both by leadershipand the incentives and disincentives that they can offeras well as altruism.

Most of the literature in game theory examines individual behavior, but Liu and her colleagues are exploring what happens when decisions are made at multiple scales. This is particularly relevant during the current COVID-19 pandemic, when decisions are made by individuals, local governments, state governments and nations. Do we act for the common good, or do we do what we perceive as serving our individual interests?

An example, in the present context, is someone who ignores shelter-at-home orders and essentially benefits from other peoples decision to comply with the order. This is whats called freeriding, Liu said.

Freeriders are protected from the virus through the decrease in transmission brought about by everyone who stays at home. This principle also applies to local and state officials making their own calculations about mitigating the risk of COVID-19. One state with a high COVID-19 case load may decide to shut down, while a neighboring state with a smaller case load may have the advantage of staying open, again benefiting from the free rider effect.

The global pandemic is the most salient threat we face at the moment, said Purush Iyer, program manager at the Army Research Office, an element of the U.S. Army Combat Capabilities Development Commands Army Research Laboratory.

While the U.S. Armys interest in network games includes understanding the impact of the adversarial groups in a host population, electronic warfare, and distributed weapon systems, we fully support exploring the impact of measures to control the spread of disease.

To begin with, the team is exploring how to model compliance or lack of compliance regarding COVID-19 orders and recommendations in their game-theory framework. The protective behaviors include not going out, wearing a mask when going out, and handwashing and sanitizer use when returning from being out.

The factors that may influence compliance often include the prevalence of COVID-19 in the local community, a persons vulnerability or proximity to vulnerable individuals, and general awareness. But they may also be affected by the timing of the order and even the words and phrases chosen to give the justification and restrictions. This aspect of the analysis will allow the team to then investigate communitywide behavior as a result of high-level policies.

Liu plans to connect behaviors identified from such data with COVID-19 case data to discover which restrictions and recommendations are most effective.

Were also interested in understanding what additional mechanisms or policies could be introduced to make the overall system more efficientfor instance, enabling more collaboration among communities rather than competition, Liu said.

She cited the way that states are currently fighting one another for federal supply of medical equipment even as some come together on a plan to begin reopening the economy.

For now, Lius team is best equipped to model strategic decisions associated with social distancing at the individual and community levels, but they have plans to include economic concerns as well. The state that is able to remain open because its neighbors are closed is a free rider in the sense of limiting virus spread, but it may also play an important economic role in manufacturing and distribution, helping to head off shortages.

The project is titled Multi-Scale Network Games of Collusion and Competition.

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Game theory and COVID-19: Major defense project pivots to explore how to coordinate safe behavior - University of Michigan News

Children of the pandemic: How will kids be shaped by the coronavirus crisis? – Science Magazine

By Joel GoldbergApr. 30, 2020 , 11:15 AM

Sciences COVID-19 reporting is supported by the Pulitzer Center.

Health professionals face a massive challenge in responding to the coronavirus. Child psychologists are no exception as they deal with mental crises in children caused by the pandemics upheaval. Some scientists see the outbreak asa natural experimenta time when a real-life event can be used to track and study changes in everything from ecosystems to human behavior. Events such as 9/11, Hurricane Katrina, and the 2008 earthquake in Sichuan, China, have already helped mental health researchers see how young people typically react during a crisis. Now, two studiesone in Toronto andanother in Baltimorewill monitor the emotions and behaviors of children and teens through this pandemic. What they reveal may teach parents and other adults how to help children in later waves of the coronavirusor during the next major crisis.

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Children of the pandemic: How will kids be shaped by the coronavirus crisis? - Science Magazine

Want to Be an Instant Expert on Film Noir? Watch This Drama – The New York Times

Maybe its our gloomy national mood, the programming on Turner Classic Movies or the Columbia Noir series currently streaming on the Criterion Channel. But cinephiles have been chattering again about film noir, a category that is notoriously difficult to define but about which every movie lover has an opinion. Say youve heard the term, but you dont know quite what it means well, you have good company. Heres a quick rundown.

To rehash an old, inevitably circular set of arguments: Noir cant simply be a genre because it transcends genre. There are noir mysteries, noir melodramas, noir costume pictures, even noir-tinged westerns and science fiction. If noir is a style, its hallmarks might include terse dialogue, an interest in seamy aspects of human behavior and black-and-white cinematography. But a cataloging would have to embrace exceptions. (Leave Her to Heaven, the ne plus ultra of femme fatale movies, is in Technicolor.)

Noir might be a mood, but thats a bit amorphous, like Justice Potter Stewarts definition of hard-core pornography: I know it when I see it. Or perhaps noir was a temporary wave rooted in anxieties about World War IIs destabilization of American home life. According to this theory, noir-like work made later than the 1950s requires a separate category, the neo-noir. And if thats the case, the neo period has gone on longer than the original.

When the French critics Raymond Borde and tienne Chaumeton tilted at an early definition in 1955, they distinguished noirs from police procedurals, which, they said, explored crime from the outside, rather than within. In the early 1970s, Paul Schrader, a critic at the time and soon to be a screenwriter and director, took a stab at a survey, arguing that noir was primarily a matter of tone. Almost every critic has his own definition of film noir, he wrote, and a personal list of film titles and dates to back it up.

Im in favor of a big tent: If you can explain why its a noir, its a noir. But dont you dare name any movie with insufficient subtext, psychological complexity or an atmosphere that doesnt chill the soul.

There are many places you might start. The gimmes include Billy Wilders much-imitated Double Indemnity with Fred MacMurray as an insurance salesman who plots with Barbara Stanwyck to kill her husband and Edgar G. Ulmers B-movie Detour, with Tom Neal as a pianist who, while hitchhiking, ends up in a car with a dead man and then beholden to a merciless blackmailer (Ann Savage). The film epitomizes noirs grim sense of fate, and the cheap production values only add to the sordid ambience.

But there may be no better place for getting a handle on what noir is and isnt than Nicholas Rays In a Lonely Place, conveniently screening in Criterions Columbia Noir series. If you enjoy it, less-revived gems (like Pushover, with a post-Indemnity MacMurray embroiled in another lust-struck scheme) are nearby for the watching.

Stream it on the Criterion Channel or rent it on Amazon, FandangoNow, iTunes, Vudu and YouTube.

Even trying to categorize In a Lonely Place is tricky: It has elements of murder mystery, melodrama and Hollywood insider scoop. Yet it is certainly one of the most forthright films to deal with domestic abuse ever to come from a major production company, let alone in the early 1950s. Here is a movie so rough-minded, so willing to be unsympathetic that it opens with its protagonist, a screenwriter named Dixon Steele (Humphrey Bogart), threatening to get into a brawl with a stranger.

Dix takes home a hat-check woman from a movie-industry haunt, on the pretense that she can tell him about a novel that he is supposed to read and potentially adapt. Ray seals our identification with the antiheroic Dix by filming the woman, Mildred (Martha Stewart), staring straight at him and the camera as she regales him with the narrative. The Bogart who had already given moviegoers Sam Spade of The Maltese Falcon, Rick of Casablanca and Philip Marlowe of The Big Sleep still has a charm, but also a sneer and a temper.

Sometime after leaving Dixs, Mildred turns up dead in the early-morning hours. Laurel Gray even the name suggests shades of uncertainty a new neighbor who saw Dix from her balcony that night, gives the police information that helps with his alibi. Then Laurel (played by Gloria Grahame) falls in love with Dix, knowing theres a chance he may be a murderer.

Part of what makes In a Lonely Place a great example of noir is that it only sounds like a whodunit; the sleuthing, which occurs mainly offscreen, is tangential to the movies true subject.

Regardless of whether Dix is the wrong man for the murder, he is a wrong man in every other sense. The police have records of fights. An actress charged that he beat her up then changed her story and said she broke her nose running into a door. Under interrogation about Mildreds death, he engages in bizarre self-sabotage, responding flippantly to questions. His death wish extends to a capacity for road rage.

His success as an artist is far behind him: We hear that he hasnt written a hit since before the war (although Laurels presence in his life jump-starts his productivity). He seems fascinated by violence, even for a dramatist. At a dinner, he uses a detective, who served under him during the war, and his wife as players in a re-enactment of the crime, imagining it in more detail than the investigators, and with such vividness that, for a moment, it almost becomes real.

And as he tightens his psychological grip on Laurel, who runs the emotional gamut of infatuation, defensiveness and terror, In a Lonely Place builds to a devastating finale. There is even an acknowledgment that tidy answers cant bring peace to the relationship: Yesterday, this wouldve meant so much to us, Laurel says. Now it doesnt matter. It doesnt matter at all. (There may be some subtext here: Those eager to learn more about Grahames marriages to Ray and eventually to Rays son apparently a teenager when the two began their affair should listen to the You Must Remember This podcast on the actress.)

Any noir recommendation right now is going to be subject to the vagaries of streaming. To Schrader, Kiss Me Deadly (1955), which came late enough in the noir period to show self-consciousness and is suffused with atomic paranoia, was the masterpiece of the form. But its only on DVD. So is Nightmare Alley (1947), with Tyrone Power as a carnival worker who tries to make it as a mentalist and is brought low by aiming too high. Its being remade by Guillermo del Toro. Who said noir is over?

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Want to Be an Instant Expert on Film Noir? Watch This Drama - The New York Times

Experts Warn COVID-19 May Not Disappear During Warm-Weather Months – Complex

About a month before coronaviruswas declared a pandemic, President Donald Trumppublicly theorized the deadly disease would "miraculously" go away once the weather heats up.

"And by the way, the virus, they're working hard, looks like by April, you know in theory when it gets a little warmer it miraculously goes away," Trump said during New Hampshire rally in February. "I hope that's true. But we're doing great in our country ... I think it's going to all work out fine. Rough stuff, I tell you, rough, rough stuff."

Experts, however, have pushed back on this theory. Though evidence suggests COVID-19 survives much longer in cooler, drier climates, researchers sayit's unlikelyhumidity and warm temperatures will eradicate the disease. Findings published by MITfound that90 percentof coronavirus transmissions recorded through March 22 occurred in regions with temperaturesbetween 37.4 and 62.6 degrees Fahrenheit. While countries in the Southern Hemisphere, where average temperatures surpassed 64.4 degrees, accounted for fewer than 10 percent of global cases. It's important to take the number of confirmedcases with a grain of salt, as a country's reportedlow infection rate could be attributed to its poor public health infrastructure and lack of testing.

Analysts in Hong Kong have also found that an increase in temperature shortened the timeframe Sars-Cov-2 could be detected. A study published by Lancet Microbeon April 2 states that the virus was "highly stable" when left atat 39 degrees Fahrenheit after two weeks, but when left at 158 degrees, the pathogen was inactive after five minutes.

"Our most striking observation to date is the powerful effect that solar light appears to have on killing the virus both on surfaces and in the air,"William Bryan, head of science and technology at the Department of Homeland Security, said in a statement toBuzzFeed News. "Weve seen a similar effect with both temperature and humidity as well, where increasing temperature, humidity, or both is generally less favorable to the virus."

Ecological modelers at the University of Connecticut also released a study, which has yet to be peer-reviewed, that foundultraviolet light was effective in killing the virus; however, experts cautioned that too much exposure to UV-rays can cause skin cells to become cancerous.

So if research has found coronavirus is harmed byheat, humidity, and sunlight, it would seem as though the pandemic would end once we roll into summer, right? Researchers aren't convinced. Though environment appears to play a role in how long the virus can survive, many experts say human behavior is likely much more important when it comes to combatting coronavirus. Why? Because there's still a lot of questions surrounding disease and how it's transmitted.

Per BuzzFeed:

If it takes a lot of virus to get someone infected, [David Relman, a professor of microbiology and immunology at Stanford University] explained, then perhaps the combined impacts of sunlight, humidity, and temperature on the viruss survivability can greatly cut down transmission. But if it only takes a little bit of virus, especially small particles of the virus that can stay aloft in the air for hours, youll still see transmission inside the offices, restaurants, and movie theaters people will be spending time in, regardless of the weather outside.

It's also important to consider the way humans' behavior changes with each season. Though many viruses tend to thrive in winter months, most individuals tend to stay in-doors and at home to avoid the cold weather. Thisisolation could slow the spread of infection, but the indoor circulation of germs and bacteria could also result in a weaken immune system. On the other hand, people tend to spend more time outdoors and in public spaces during the warm-weather months. The increase in social interaction could lead to a spike in transmission; but will the summer climate lower the risks of infections? At this point, we'll have to wait and see.

"Weather and climate can only explain part of the transmission, the other factors are nonenvironmental social distancing, washing hands, covering your cough, staying home when you are sick and these factors are probably the most important in a pandemic," Jesse Bell, a climate health expert at the University of Nebraska, told BuzzFeed. "Understanding climate and weather will only tell you when the environmental conditions are optimal for the spread of the virus."

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Experts Warn COVID-19 May Not Disappear During Warm-Weather Months - Complex

‘Face to Face Time’ Review: Izzy Shill’s SXSW short film is a hilarious case study of insecurity and deceit – MEAWW

Spoilers for Face to Face Time

2020 has witnessed a massive shift in human behavior. Thanks to the coronavirus pandemic, being locked inside homes has become a reality for millions and millions of people across the globe. A state of lockdown, however necessary it is, does not change the fact that we still need contact with other human beings. Subsequently, video chats have become our new best friend. In that respect, Izzy Shills SXSW short film Face to Face Time comes as a rude shock.

The six-minute-something film that stars Shill as Claire and Sean Patrick McGowan as Danny, a man shes been out on two dates with and has a big crush on, is disturbingly funny while being painfully human. It begins with Claire preparing herself. She tidies her dress, makes sure her breasts look good, cleans her bed and then rolls over it a bit to make it just the right amount of messy. She obsesses over every detail in the frame. What frame? The frame of her phone camera as she hits Danny up on FaceTime.

Claires prep, as one could foresee, is met with lackluster enthusiasm from the man of her recent dreams. But it only gets worse. Aside from commenting that Claire looks like a cam girl because of the way she had placed her phone, Danny spends more time texting than actually paying attention to her. And yet, things get worse.

When Claire tries to initiate some extremely awkward FaceTime sex, Danny pays a bit more attention. But he seems entirely too interested in getting his own rocks off rather than having an intimate time with Claire. He makes inane comments like nice bra, whats the color of your underwear, while violently masturbating to what he sees on the screen. Even as Claire tries to make the experience hotter, Danny already looks like hes about to finish. And then things get even worse.

The laptop or iPad or whatever Danny was talking to Claire on, tilts downward and we catch a glimpse of whats happening in the southern hemisphere. Dannys supposed crescendo of passion was an act. He was only pretending to masturbate. Obviously, Claire is hurt. She feels angry and disgusted and sad and decides to leave. In a bid to save himself, Danny tries to flatter, says he likes her, and then starts to explain why he was acting turned on.

As Claires interest piques, the chat hangs and the screen freezes.

Shills film is positively a nightmare for all couples and would-be couples who find themselves separated by the COVID-19 lockdown. It begs them to question if their passionate escapades on video chats are as real as they seem. If Gone Girl managed to make partners mistrust each other, wondering if the other was always planning to ruin their lives, Face to Face Time plants a hilarious seed of mistrust among those who partake in sexting, not just now, but really at any time.

Both Shill and McGowan are fantastic in their performances as they emulate the tropes of the needy and the casually disinterested. The story despite its seemingly trivial subject matter makes a delightful case study of human behavior in the space of technology-based communication. Shills writing and performance also bring out themes of insecurity, low self-esteem, and measuring ones self-worth in external loci.

In just about six minutes, this film entertains, tickles, and makes you self-conscious, forcing you to reevaluate your past experiences. And by any standard, thats a spectacular feat.

'Face to Face Time' is part of Amazon Prime Videos SXSW 2020 Film Festival Collection which is available to be streamed from April 27May 6.

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'Face to Face Time' Review: Izzy Shill's SXSW short film is a hilarious case study of insecurity and deceit - MEAWW

Eye Tracking Market (COVID-19 Impact) Outlooks 2020: Industry Analysis, Demand, Cost Structures, Growth rate and Forecasts to 2024 – Bandera County…

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Chapter 1 About the Industry1.1 Study Assumptions1.2 Scope of the Report

Chapter 2 World Market Competition LandscapeChapter 3 World Market shareChapter 4 Supply Chain AnalysisChapter 5 Company ProfilesChapter 6 Globalisation & TradeChapter 7 Distributors and CustomersChapter 8 Import, Export, Consumption and Consumption Value by Major CountriesChapter 9 World Market Forecast through 2024Chapter 10 Key success factors and Market Overview

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Eye Tracking Market (COVID-19 Impact) Outlooks 2020: Industry Analysis, Demand, Cost Structures, Growth rate and Forecasts to 2024 - Bandera County...