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Sensorion Announces Positive Preliminary Preclinical Data From Its Otoferlin Gene Therapy Program | DNA RNA and Cells | News Channels -…

DetailsCategory: DNA RNA and CellsPublished on Tuesday, 09 June 2020 10:59Hits: 229

MONTPELLIER, France I June 09, 2020 I Sensorion (Paris:ALSEN) (FR0012596468 ALSEN) a pioneering clinical-stage biotechnology company which specializes in the development of novel therapies to restore, treat and prevent within the field of hearing loss disorders, announces promising new preliminary data in non-human primates from its ongoing gene therapy program targeting the Otoferlin encoding gene (OTOF).

The following results relate to the first of two preclinical programs conducted under a broad research partnership with Institut Pasteur (Paris). The partnership aims to develop gene therapies to correct, safely and efficiently, hereditary monogenic forms of deafness. The first program targets specifically deafness caused by a mutation of the gene encoding for Otoferlin, which is highly present in cochlear sensory cells and is critical for hearing.

The green fluorescent protein (GFP) was used as an intracellular reporter molecule to assess gene transfer and expression. The selected adeno-associated virus (AAV), a safe and effective vector for gene therapy, enabled expression of the GFP protein under control of the selected promoter. An intense fluorescence due to GFP was detected by immunostaining in the cochlear tissue of two out of three treated animals, demonstrating adequate tropism for inner ear tissue. Remarkably, the expression of GFP was mainly robust in the inner hair cells, indicating an effective transduction of the relevant target cells at levels compatible with future therapeutic intervention of Otoferlin deficiency by gene therapy. These results are expected to be published.

Graldine Honnet, Chief Medical Officer Sensorion, observes: One of the challenges in gene therapy is the precise and safe delivery of the therapeutic to the targeted tissue. In this non-human primate study, the surgical procedure went smoothly in three animals. No infections were observed, either pre- or post-operation, and a perfect scar was obtained. There were no side effects such as transient vertigo resulting from the procedure.

The data confirms that the OTOF program is very promising and represents an important step forward to successfully achieving our gene therapy development to treat hereditary monogenic forms of hearing loss. Our collaboration with one of the leading academic institutions in the field of hearing as well as with one of the top pediatric ENT hospitals in the world sets a solid foundation to create a robust ecosystem in gene therapy development for hearing loss. The preclinical data further validates the potential of our collaboration to develop treatments that could revolutionize the lives of patients with disabling genetic inner ear diseases, remarked Nawal Ouzren, CEO Sensorion.

Sensorions exclusive agreement is with the Genetics and Physiology of Hearing Unit at Institut Pasteur, led by Professor Petit, whose laboratory has developed world-class expertise over the last 25 years in the molecular physiology and pathophysiology of the hearing system and has generated data supporting the development of potential gene therapies. The agreement grants Sensorion exclusive rights to obtain the full intellectual property licenses to develop and market drug products in gene therapy coming from collaborative projects for the restoration, treatment, and prevention of hearing disorders. The French government awarded up to 9.7 million to the AUDINNOVE consortium, which includes Necker Hospital, Institut Pasteur and Sensorion, to support the development of the OTOF program into human clinical trials.

About Sensorion

Sensorion is a pioneering clinical-stage biotechnology company, which specializes in the development of novel therapies to restore, treat and prevent within the field of hearing loss disorders. Its clinical-stage portfolio includes one Phase 2 product: SENS-401 (Arazasetron) for sudden sensorineural hearing loss (SSNHL). Sensorion has built a unique R&D technology platform to expand its understanding of the pathophysiology and etiology of inner ear related diseases enabling it to select the best targets and modalities for drug candidates. The Company is also working on the identification of biomarkers to improve diagnosis of these underserved illnesses. In the second half of 2019, Sensorion launched two preclinical gene therapy programs aiming at correcting hereditary monogenic forms of deafness including Usher Type 1 and deafness caused by a mutation of the gene encoding for Otoferlin. The Company is uniquely placed, through its platforms and pipeline of potential therapeutics, to make a lasting positive impact on hundreds of thousands of people with inner ear related disorders, a significant global unmet medical need. http://www.sensorion-pharma.com

SOURCE: Sensorion

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Sensorion Announces Positive Preliminary Preclinical Data From Its Otoferlin Gene Therapy Program | DNA RNA and Cells | News Channels -...

After first full week of virtual summer courses, students have mixed reactions – The Daily Pennsylvanian

Many students are using online summer classes to fulfill graduation requirements and explore prospective fields of study. Credit: Emily Xu

After students' summer plans were canceled due to the coronavirus, many are taking online classes to fulfill graduation requirements and explore prospective fields of study.

Students found little differences in remote summer learning in comparison to what they experienced during the latter half of the spring semester, and said some of their classes are better suited to online learning than others.

Rising College sophomore Helen Wu said she was motivated to take online summer courses for credit because as an international student, she does not have proper authorization to work, study, or participate in a virtual internship in the United States. She is taking "Intro to Linguistics," "Intro to Geology," and "Deviance and Social Control."

"All of these classes are fulfilling some type of requirement, Wu said. My rationale was that when I get back on campus and I can take classes in person, I want to take classes I really like."

Rising College sophomore Meghan Fersten is taking "Autonomic Physiology" to help her decide if she wants to declare a major in neuroscience. The summer class was originally designed to take place half online and half in-person, which she said made the transition to remote learning smoother.

I think for [the professor] to adapt it for online wasn't difficult but she ended up making it really engaging it even with the online meetings, Fersten said.

On the other hand, Wu said her online classes had some clear limitations, as she is unable to look at and touch the rocks she is learning about in her "Intro to Geology" class. She added, however, that her "Intro to Linguistics" class is able to have more intimate discussions with a much smaller online class size.

During the school year, students taking "Intro to Linguistics" are graded based on their exam performance and the creation of a journal. In Wus summer course, however, students earn points in discussions and smaller, more frequent, assignments.

Wu and Fernsten agreed that their professors and TAs offered enough office hours and were very flexible outside of class.

Penn announced on April 13 that all summer session classes would be conducted online and courses would begin on May 26. Over 1,200 students registered for one of the three summer sessions which run for either six or 11 weeks and are often smaller in size in comparison to courses during the academic year.

"Overall, the online experience has been pretty good and pretty much the same over spring and summer," rising Wharton sophomore Tianhe Xie, who is enrolled in "Accounting and Financial Reporting," said.

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After first full week of virtual summer courses, students have mixed reactions - The Daily Pennsylvanian

The facts about smoking and the practicality of stopping – Kenya Broadcasting Corporation

The World Health Organisation estimates there to be 1.1 billion smokers on planet earth, 80% of whom live in low and middle income countries. Up to 50% of those exposed to tobacco smoke die as a result of the habit and the harm is all the more vivid when one considers that deaths are at a rate of 8 million people annually.

This is equivalent to wiping out the sum of the populations of Nairobi, Kampala and Mombasa annually. More than an eighth of these deaths are amongst people who choose not to smoke but inhale second-hand smoke from people smoking around them. The list of health conditions associated with the habit is long and includes 14 different cancers, long term and irreversible lung conditions, cardiovascular illnesses, impotence and infertility, and diseases affecting bone health. Not to mention smoking increases the risk of contracting COVID-19.

But what exactly causes such an intense addiction to smoking? The mechanisms behind addiction are complex and involve both the physiology of the central nervous system, and psychology. Most career smokers will attest to multiple failed attempts to quit through their lifetimes.

Just know that it is never too late to stop smoking and the earlier you quit the better. In fact the benefits of quitting kick in within twenty minutes of putting out a cigarette. They range from immediate important physiological benefits to reversal of heart attack and stroke risks to normal levels within five to fifteen years of quitting. Studies have shown that people diagnosed with lung cancer have better outcomes when going into cancer therapy if they quit, and have a higher success rate at sustaining cessation.

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How about you seek professional help such as a support program to help quit? It may be easier than going it alone.Whichever route a person decides to take, the biggest player in the process is the quitter. The will to quit is a key and necessary ingredient. For the smokers who are not ready to quit, the first step is always to understand the health and economic harm caused by the habit, on both oneself and ones family, and the benefits of quitting.

Do not let previous failed attempts of quitting get you down; however numerous and spectacular. Each failed attempt is filled with lessons on what to do differently. Incremental targets are useful. This means quitting for a day, then trying for two days, then three and so forth to the point where there is too much to lose by smoking that one cigarette. Seeking inspiration from successful quitters is a useful tactic, and there are always important lessons on what works, and what does not. It is not uncommon that stress, anxiety and fear burden a quitter, especially when ponders the onerous task ahead.

Yoga and meditation, adopting alternative relaxation techniques and surrounding oneself with friends who cherish and support the quit process will aid you immensely. Adopting a healthy lifestyle with exercise and healthy diet usually helps condition the mind overall positivity.

Set a quit date weeks ahead and inform those around you of the date and ask for their support and understanding. This includes family, colleagues and friends. Of course remove any tobacco products from your surroundings.

The first few days and weeks are the hardest as it always is when breaking any habit. You will experience withdrawal symptoms in the form of coughs, headaches, cravings and weight gain from an increased appetite. Some people experience a volatile mood, difficulty concentrating, poor sleep and even symptoms that mimic the flu. Note that these symptoms rarely last longer than a month.

Good luck.

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The facts about smoking and the practicality of stopping - Kenya Broadcasting Corporation

Southampton is the best uni for Physiotherapy in the UK – The Tab

Uni league tables were released today and were up three places overall

The University of Southampton has been officially ranked the best uni for Physiotherapy in the country, it is also the second-best in the country for Occupational Therapy and Aural & Oral Sciences.

According to the Complete University Guide League Tables 2021 released today, the uni ranked 17th in the country alongside Manchester, and is three places up from last year. Southampton was ranked higher than numerous Russel Group unis such as Kings, Nottingham, York, Newcastle, Cardiff, and Liverpool.

The uni also had 12 other courses that were ranked within the top ten in the country. Southampton is the 4th best uni in the country for Electrical and Electronic Engineering, and ranked 5th for Music. For Nursing, Southampton is the 6th best in the country.

Other courses in the top ten include Iberian languages (Spanish and Portuguese), Mechanical Engineering, Geology, Anatomy and Physiology, Aeronautical and Manufacturing Engineering, Marketing, German, French and Civil Engineering.

Southamptons graduate prospects were rated 82.1/100, more than many unis that had ranked higher in the league table. Our research intensity was rated 0.90 higher than Oxfords 0.87.

Solent has been ranked 100th in the country, its highest ranking since 2017, whilst our Varsity rivals Portsmouth were ranked 61st.

Meet the Soton student who has set up a diverse greetings card business

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Heres the last goodbyes every final year wishes they could have said to Soton

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Southampton is the best uni for Physiotherapy in the UK - The Tab

Nearly 600 and Counting US Health Workers Have Died Of COVID-19 – Lake County Record-Bee

Nearly 600 front-line health care workers appear to have died of COVID-19, according to Lost on the Frontline, a project launched by The Guardian and KHN that aims to count, verify and memorialize every health care worker who dies during the pandemic.

The tally includes doctors, nurses and paramedics, as well as crucial health care support staff such as hospital janitors, administrators and nursing home workers, who have put their own lives at risk during the pandemic to help care for others. Lost on the Frontline has now published the names and obituaries for more than 100 workers.

A majority of those documented were identified as people of color, mostly African American and Asian/Pacific Islander. Profiles of more victims, and an updated count, will be added to our news sites twice weekly going forward.

There is no other comprehensive accounting of U.S. health care workers deaths. The Centers for Disease Control and Prevention has counted 368 COVID deaths among health care workers, but acknowledges its tally is an undercount. The CDC does not identify individuals.

The Guardian and KHN are building an interactive, public-facing database that will also track factors such as race and ethnicity, age, profession, location and whether the workers had adequate access to protective gear. The database to be released this summer will offer insight into the workings and failings of the U.S. health care system during the pandemic.

In addition to tracking deaths, Lost on the Frontline reports on the challenges health care workers are facing during the pandemic. Many were forced to reuse masks countless times amid widespread equipment shortages. Others had only trash bags for protection. Some deaths have been met with employers silence or denials that they were infected at work.

The number released so far reflects the 586 names currently in the Lost on the Frontline internal database, which have been collected from family members, friends and colleagues of the deceased, health workers unions, media reports, unions, among other sources. Reporters at KHN and The Guardian are independently confirming each death by contacting family members, employers, medical examiners and others before publishing names and obituaries on our sites. More than a dozen journalists across two newsrooms as well as student journalists are involved in the project.

Many of the health care workers included here studied physiology and anatomy for years. They steeled themselves against the long hours theyd endure. Emergency medical technicians raced by ambulance to help. Others did the cleanup, maintenance, security or transportation jobs needed to keep operations running smoothly.

They undertook their work with passion and dedication. They were also beloved spouses, parents, friends, military veterans and community activists.

None started 2020 knowing that simply showing up to work would expose them to a virus that would kill them.

This project aims to capture the human stories, compassion and heroism behind the statistics. Among those lost were Dr. Priya Khanna, a nephrologist, who continued to review her patients charts until she was put on a ventilator. Her father, a retired surgeon, succumbed to the disease just days after his daughter.

Susana Pabatao, one of thousands of Philippine health providers in the United States, became a nurse in her late 40s. Susana died just days after her husband, Alfredo, who was also infected with COVID-19.

Dr. James Goodrich, a renowned pediatric neurosurgeon, acclaimed for separating conjoined twins, was also remembered as a renaissance man who collected antique medical books, loved fine wines and played the didgeridoo.

Some of the first to die faced troubling conditions at work. Rose Harrison, 60, a registered nurse, wore no mask while taking care of a COVID-19 patient at an Alabama nursing home, according to her daughter. She felt pressured to work until the day she was hospitalized. The nursing home did not respond to requests for comment.

Thomas Soto, 59, a Brooklyn radiology clerk faced delays in accessing protective gear, including a mask, even as the hospital where he worked was overwhelmed with COVID-19 patients, his son said. The hospital did not respond to requests for comment.

The Lost on the Frontline team is documenting other worrying trends. Health care workers across the U.S. said failures in communication left them unaware they were working alongside people infected with the virus. And occupational safety experts raised alarms about CDC guidance permitting workers treating COVID patients to wear surgical masks which are far less protective than N95 masks.

The Occupational Safety and Health Administration, the federal agency responsible for protecting workers, has launched dozens of fatality investigations into health workers deaths. But recent agency memos raise doubts that many employers will be held responsible for negligence.

As public health guidelines have largely prevented traditional gatherings of mourners, survivors have found new ways to honor the dead: In Manhattan, a medical resident played a violin tribute for a fallen co-worker; a nurses union placed 88 pairs of shoes outside the White House commemorating those who had died among their ranks; fire departments have lined up trucks for funeral processions and held last call ceremonies for EMTs.

The Lost on the Frontline death toll includes only health care workers who were potentially exposed while caring for or supporting COVID-19 patients. It does not, for example, include retired doctors who died from the virus but were not working during the pandemic.

The number of reported deaths is expected to grow. But as reporters work to confirm each case, individual deaths may not meet our criteria for inclusion and, therefore, may be removed from our count.

You can read the first 100 profiles here online at https://khn.org/news/lost-on-the-frontline-health-care-worker-death-toll-covid19-coronavirus/. And if you know of a health care worker who died of COVID-19, please share their story with us.

Christina Jewett: ChristinaJ@kff.org, @by_cjewett

Melissa Bailey: @mmbaily

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Nearly 600 and Counting US Health Workers Have Died Of COVID-19 - Lake County Record-Bee

Massive Growth in Neuroscience Market 2020 Focusing on Growth, Demand & Scope by 2026| GE Healthcare , Siemens Healthineers , Noldus Information…

Neuroscience Market research is an intelligence report with meticulous efforts undertaken to study the right and valuable information. The data which has been looked upon is done considering both, the existing top players and the upcoming competitors. Business strategies of the key players and the new entering market industries are studied in detail. Well explained SWOT analysis, revenue share and contact information are shared in this report analysis.

Neuroscience Market is growing at a High CAGR during the forecast period 2020-2026. The increasing interest of the individuals in this industry is that the major reason for the expansion of this market.

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Key Players Profiled in This Report:

GE Healthcare , Siemens Healthineers , Noldus Information Technology , Mightex Bioscience , Thomas RECORDING GmbH , Blackrock Microsystems , Tucker-Davis Technologies , Plexon , Phoenix Technology Group , NeuroNexus , Alpha Omega

The key questions answered in this report:

Various factors are responsible for the markets growth trajectory, which are studied at length in the report. In addition, the report lists down the restraints that are posing threat to the global Neuroscience market. It also gauges the bargaining power of suppliers and buyers, threat from new entrants and product substitute, and the degree of competition prevailing in the market. The influence of the latest government guidelines is also analyzed in detail in the report. It studies the Neuroscience markets trajectory between forecast periods.

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Massive Growth in Neuroscience Market 2020 Focusing on Growth, Demand & Scope by 2026| GE Healthcare , Siemens Healthineers , Noldus Information...

Neuroscience Market 2024 Expected to reach Highest CAGR including major key players GE Healthcare, Siemens Healthineers, Noldus Information…

Due to the pandemic, we have included a special section on the Impact of COVID 19 on the NeuroscienceMarket which would mention How the Covid-19 is Affecting the Industry, Market Trends and Potential Opportunities in the COVID-19 Landscape, Key Regions and Proposal for Neuroscience Market Players to battle Covid-19 Impact.

The NeuroscienceMarket report is one of the most comprehensive and important data about business strategies, qualitative and quantitative analysis of Global Market. It offers detailed research and analysis of key aspects of the Neuroscience market. The market analysts authoring this report have provided in-depth information on leading growth drivers, restraints, challenges, trends, and opportunities to offer a complete analysis of the Neuroscience market.

Top Leading players covered in the Neuroscience market report: GE Healthcare, Siemens Healthineers, Noldus Information Technology, Mightex Bioscience, Thomas RECORDING GmbH, Blackrock Microsystems, Tucker-Davis Technologies, Plexon, Phoenix Technology Group, NeuroNexus, Alpha Omega and More

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Product Type SegmentationWhole Brain ImagingNeuro-MicroscopyElectrophysiology TechnologiesNeuro-Cellular ManipulationStereotaxic Surgeries

Industry SegmentationHospitalsDiagnostic LaboratoriesResearch InstitutesOther

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Regions Covered in the Global Neuroscience Market: The Middle East and Africa (GCC Countries and Egypt) North America (the United States, Mexico, and Canada) South America (Brazil etc.) Europe (Turkey, Germany, Russia UK, Italy, France, etc.) Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

Years Considered to Estimate the Neuroscience Market Size:History Year: 2015-2019Base Year: 2019Estimated Year: 2020Forecast Year: 2020-2024

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Neuroscience Market 2024 Expected to reach Highest CAGR including major key players GE Healthcare, Siemens Healthineers, Noldus Information...

Neuroscience explains why youre having trouble concentrating during the pandemic – AlterNet

Batrice Pudelko, Universit TLUQ

Fear, anxiety, worry, lack of motivation and difficulty concentrating students cite all sorts of reasons for opposing distance learning. But are these excuses or real concerns? What does science say?

At the beginning of the pandemic, when universities and CEGEPs, Qubecs junior colleges, were putting in place scenarios to continue teaching at a distance, students expressed their opposition by noting that the context was not conducive to learning.

Teachers also felt that the students were simply not willing to continue learning in such conditions. A variety of negative emotions were reported in opinion columns, letters and surveys. A petition was even circulated calling for a suspension of the winter session, which Education Minister Jean-Franois Roberge refused.

Students are not the only ones who have difficulty concentrating on intellectual tasks. In a column published in La Presse, Chantal Guy says that like many of her colleagues, she cant devote herself to in-depth reading.

After a few pages, my mind wanders and just wants to go check out Dr. Arrudas damn curve, Guy wrote, referring to Horacio Arruda, the provinces public health director. In short: Its not the time thats lacking in reading, its the concentration, she said. People dont have the head for that.

Why do students feel they dont have the ability for studies? Recent advances in cognitive science provide insights into the links between negative emotions and cognition in tasks that require sustained intellectual investment.

The heart has its reasons which reason knows not. This sentence from 17th-century philosopher Blaise Pascal sums up well the way in which western science has long separated the emotions of the hot universe from those of the cold universe in human rationality.

Walter Cannons physiological research has provided a first explanation of how emotions, especially negative emotions, take over our minds. He showed that emotion is a physiological warning system in the body, activating several structures below the cerebral cortex.

One of these structures, the amygdala, is now proving to be particularly important. The amygdala is rapidly activated in the face of threatening stimuli and allows us to learn to be wary of them. Faced with what could be a snake hidden among the branches, an animal will awaken its senses, alert its muscles and react quickly, without having the luxury of analyzing whether the slender shape is a snake or a stick.

For example, the emotions aroused by the sight of a snake in the grass or an untrustworthy political figure can capture our attention in spite of ourselves.In humans, the amygdala activates quickly and automatically in response to social stimuli loaded with negative emotions. Neuroscience research shows that people are not only highly sensitive to the emotional charge of their perceptions but they are also unable to ignore it.

One might object that for many people, fortunately, COVID-19 does not pose the same kind of threat as a snake encountered in the undergrowth. Our social systems provide us with protections that are previously unimaginable and we are much better prepared to deal with crisis situations.

And, learning situations established by educational institutions whether in-person classes or online classes always require that students focus their attention and consciously control their thoughts. As teachers know from experience, a great challenge while leading any lesson is keeping the attention of all students by ensuring that they remain focused on the activity at hand.

The cognitive psychologist Daniel Kahneman, a Nobel Prize winner in 2002, was among the first to propose that attention is a limited cognitive resource and that some cognitive processes require more attention than others. This is particularly the case for activities involving the conscious control of cognitive processes (such as reading or writing academic papers), involving what Kahneman calls System 2 thinking. That requires attention and mental energy.

In working memory, attention acts as a supervisor of cognitive resource allocation and a controller of action execution. The brain circuits associated with working memory and executive functions are those of the prefrontal cortex.Limited attention capacity is also at the heart of the theories proposing that conscious and controlled cognitive processes are carried out in working memory, which is compared to a mental space capable of processing a limited amount of new information.

Researchers have long believed that the processing of emotions through the amygdala does not depend on the attention resources of working memory. However, evidence is accumulating in favour of the opposite hypothesis, indicating that the circuits connecting the amygdala and the prefrontal cortex play an important role in discriminating between relevant and irrelevant information for the current activity.

For example, emotional stimuli were found to interfere with the performance of a working memory task especially since they were not very relevant to the task. Furthermore, as the cognitive load associated with the task increased (for example, when the task required more cognitive resources), the interference of emotional stimuli not relevant to the task also increased. Thus, it would appear that the more a task requires cognitive effort and concentration, the more easily we are distracted.

Much of the extensive research on anxiety by psychologist Michael Eysenck and colleagues supports this view. They show that people who are anxious prefer to focus their attention on stimuli associated with the threat, unrelated to the task at hand. These stimuli may be internal (worrisome thoughts) or external (images perceived as threatening).

This is also the case with worry as the repeated experience of seemingly uncontrollable thoughts about possible negative events. Both anxiety and worry eat up the attention and cognitive resources of working memory, resulting in decreased cognitive performance, especially for complex tasks.

Other research indicates that feelings of mental fatigue increase when performing a task while trying not to respond to outside demands. It has been suggested that mental fatigue is a particular emotion that tells us that our mental resources are being depleted.

Overall, this research suggests that we are depleting our attention resources to avoid paying attention to irrelevant, but emotionally charged information! It is now better understood why it is so difficult and exhausting to avoid checking ones email while reading a scientific text, to switch from email to Facebook and from Facebook to COVID-19 news coverage, when we are concerned about the curve or death toll in seniors homes.

Research in cognitive sciences today confirms what we know intuitively: studying requires attention, time and availability of mind. This research shows that cognitive and emotional processes are so intertwined in the brain that, for some researchers, such as Antonio Damasio, no thought is possible without emotion.

Not surprisingly, then, in a context full of messages about the dangers of the pandemic, students find it difficult to focus sustainably on their studies and most seem to lack quality time for reading or writing.

Batrice Pudelko, Professeure en psychologie de lducation, Universit TLUQ

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Neuroscience explains why youre having trouble concentrating during the pandemic - AlterNet

Shawnee state graduate receives bachelor’s and high school degrees through College Credit Plus – Pike County News Watchman

One of the youngest graduates from Shawnee State University received her degree during the Spring 2020 Commencement May 16.

Abby Keith, 17, finished the academic year earning both her high school diploma and her Bachelor of Arts in Psychology.

I am fortunate to have a family who have been nothing but supportive of my academic endeavors, Keith said. My mother drove me to class every day for four years until I was old enough to get my license.

Beginning in Shawnee States College Credit Plus program just after finishing seventh grade, the 12-year-old embraced the opportunity for students to begin college studies early. At SSU, last year more than 650 students were enrolled in classes through the program while still taking their middle school or high school courses.

The tuition is paid through the students school district and state reimbursement in the program. Students are able to get a head start on required courses and, with certain qualifications, even continue to more specialized courses as they work with a College Credit Plus advisor toward their academic goals.

"Abby's achievement is amazing," said Amanda Means, SSU Assistant Director of Recruitment and Transfer.

"The four-year degree she has earned early, the head start on joining the workforce, and the cost savings are what makes the CCP program an amazing opportunity for Ohio students who qualify and work hard.

Keith continued to take classes at Shawnee State University while earning her degree from Western Brown High School in Mt. Orab.

Abby was a very good student, Dr. Kyle Vick, SSU psychology professor, said. She would ask good questions in and after class, and always turned in excellent work. I wish her the best in her future endeavors.

With a focus on science and a keen interest in neurology, Keith was able to pursue all the courses to build a foundation toward a career in neuroscience. She has been accepted into the neuroscience graduate program at Drexel University in Philadelphia, where she plans to work on helping others facing daunting challenges.

Currently, research is focused on neurological issues, such as addiction and traumatic brain injury, Keith said. Neuroscience combines my shared love of biology and psychology, and my hope is to do something great in the world.

Keith is grateful for the support she received both at home and school during her academic journey so far.

Being able to achieve this accomplishment at my age means so much to me, she said.

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Shawnee state graduate receives bachelor's and high school degrees through College Credit Plus - Pike County News Watchman

ST Math Expands Statewide in Partnership with the One8 Foundation and MA DESE – GlobeNewswire

JiJi invites Mass Math students to join the Summer Challenge.

Boston, Mass., June 09, 2020 (GLOBE NEWSWIRE) -- The One8 Foundation, Mass STEM Hub, MIND Research Institute, and Massachusetts Department of Elementary and Secondary Education (MA DESE) have partnered to provide access to ST Math, a leading conceptual math program, in grades K-6 for Massachusetts schools. This 2020 Mass Math Initiative will keep meaningful learning happening over the summer and through the 2020-21 school year.

ST Math is a visual instructional program that leverages the brain's innate spatial-temporal reasoning ability to solve mathematical problems. ST Maths unique, patented approach provides students with equitable access to learning the states math standards through challenging puzzles, non-routine problem solving, and informative feedback.

Nearly 200 schools from 38 different districts including Boston Public Schools, Cambridge Public Schools, Lynn Public Schools, Peabody Public Schools, Pittsfield Public Schools, and Worcester Public Schools applied to be considered for the program.

The 2020 Mass Math Initiative was developed, in large part, to help mitigate both summer learning loss and the COVID slide, a term used to describe the potential impact of school closures on learning and achievement. According to a report published in April 2020 by NWEA, student progress in math is at greatest potential for risk by a COVID slide, and students could return to school in the fall with less than 50% of the learning gains and in some grades, nearly a full year behind what we would observe in normal conditions. Students use of ST Math can help reverse that trajectory.

In just two short years, we have been amazed at the impact we are seeing in Massachusetts with ST Math, said Brett Woudenberg, CEO of MIND Research Institute, the nonprofit neuroscience and education organization behind ST Math. The One8 Foundations support of MIND, with ST Math and beyond, has been vital to creating deeper, more conceptual mathematical learning in a diverse group of students and teachers. We are grateful for their expanded partnership and thankful to be able to provide ST Math statewide.

The One8 Foundation began funding the ST Math Massachusetts Program in 2017 with an initial cohort of 54 Massachusetts schools. Over the past two years, the program grew to encompass 165 schools, totalling approximately 55,000 students. One8 Foundation has provided additional support for the quality implementation of ST Math for schools receiving grants through Mass STEM Hub, their school implementation team. Todays announcement further expands this highly effective conceptual math program to more elementary schools across the state.

Educators are working hard to adapt to the need for effective online learning options, said Joanna Jacobson, President of the One8 Foundation. We have supported the scale of ST Math for elementary schools in the state over the last two years because of the demonstrated student results and because children love to play these math games keeping them engaged in their learning. Helping more schools quickly deploy ST Math is an important initiative.

Students will be encouraged to play ST Math over the summer and complete puzzles alongside JiJi, ST Maths penguin mascot. In an effort to encourage as much participation as possible, the Summer Challenge will include prizes and celebrations throughout the summer beginning the week of June 15th. Prizes will be awarded to classrooms and educators who demonstrate progress, perseverance, and usage. Massachusetts Commissioner of Elementary and Secondary Education Jeffrey Riley will also publicly celebrate specific program milestones throughout the summer.

Were glad to see ST Math become an option for additional Massachusetts schools this summer, especially as we all look for ways to maintain student learning during the COVID-19 pandemic, Commissioner Riley said. I am grateful to One8 Foundation, Mass STEM Hub and MIND Research Institute for making this opportunity available.

About MIND Research InstituteMIND Research Institute is a neuroscience and education social impact organization dedicated to ensuring that all students are mathematically equipped to solve the worlds most challenging problems. MIND is the creator of ST Math, a PreK-8 visual instructional program that leverages the brain's innate spatial-temporal reasoning ability to solve mathematical problems. Its unique, patented approach provides students with equitable access to learning through challenging puzzles, non-routine problem solving, and informative feedback. MIND has also developed programs under MathMINDs to provide students, teachers and families dynamic ways to actively engage with math, and to close the experience gap for all learners. MathMINDs includes Family Nights, the national K-12 Game-a-thon and MathMINDs Games. For more information, visit mindresearch.org.

About One8 FoundationThe One8 Foundation propels and supports outstanding leaders with compelling ideas that deliver scaled, sustainable social impact. Education is a priority area of strategic giving for the One8 Foundation, with a focus on preparing students for a rapidly changing high-tech world through applied learning and STEM education. To learn more, visit one8.org.

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ST Math Expands Statewide in Partnership with the One8 Foundation and MA DESE - GlobeNewswire