All posts by medical

Chan Zuckerberg Initiative awards $1.49 million to Stanford researchers | The – Stanford University News

by Stanford Medicine on June 13, 2020 1:30 pm

The Chan Zuckerberg Initiative (CZI) has awarded $1.49 million to research projects involving Stanford Medicine scientists who will investigate emerging ideas about the role of inflammationin disease. The grants will be awarded over a two-year period.

Ami Bhatt is one of the researchers on the Analyzing how inflammation affects the aging brain project that will be receiving funds from the Chan Zuckerberg Initiative. (Courtesy Stanford Medicine)

CZI is a philanthropic organization established byFacebookfounder Mark Zuckerberg and his wife, Priscilla Chan, in 2015.

Following are short descriptions of the projects, their funding amounts and the names of their investigators (lead investigators are listed first):

Analyzing how inflammation affects the aging brain ($525,000): ANNE BRUNET, professor of genetics; AMI BHATT, assistant professor of genetics and of hematology; CHRIS GARCIA, professor of structural biology and of molecular and cellular physiology.

Imaging gut immune cells and microbes to understand health and disease($300,000): LUCY ERIN OBRIEN, assistant professor of molecular and cellular and biology; KC HUANG, professor of bioengineering and of microbiology and immunology.

Studying vascular disease in black and Hispanic patients ($525,000): JOSEPH WU, professor of cardiovascular medicine and director of the Stanford Cardiovascular Institute; ELSIE GYANG ROSS, assistant professor of vascular surgery and of biomedical informatics research; and PHILIP TSAO, professor of cardiovascular medicine.

Understanding how stress and social disparity affect preterm birth ($140,000): Jingjing Li, assistant professor of neurology (UCSF); GARY SHAW, professor of pediatrics; and DAVID K. STEVENSON, professor of pediatrics.

Read this article and more on the Stanford Medicine website.

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Chan Zuckerberg Initiative awards $1.49 million to Stanford researchers | The - Stanford University News

Letter To The Editor: Love Overcomes Hate – Los Alamos Daily Post

By BEATRICE N. ODEZULU, MBALos Alamos

I am writing as an African American woman with four kids and a husband trying to process the tragic death of Mr. George Floyd. We have mourned and now are trying to heal.

My children are asking me questions which I do not have any answer to. However, a Scripture popped up in my heart, Love overcomes hate. Love your neighbor means treat them the way you would want to be treated.

The community has a huge role to play in creating an environment where love prevails. When you see a person, see them as a human being first. We all bleed, hurt, and want good things in life. The color of my skin does not take away my humanity. It is deep ignorance to think that the quantity of melanin (pigment that determines skin tone) that someone has, makes them less human. When donating blood or signing up to be an organ donor, nobody cares what your skin color is. Yet, skin color has resulted in untold hardship for thousands.

Some may not understand the term white privilege because they have never been on the other side of the fence. It means the hurdles and glass ceilings you dont have to constantly deal with in the ordinary course of living, because you have the right skin color. If you have not been followed around while shopping, you are enjoying that privilege. [Thats the reason I dont like shopping. My husband does all the shopping].

In 2012, I went with my then 7-year-old girl to our beloved CB Fox to shop. A clerk kept following us so that my daughter innocently asked why the woman was following us. I told her she wanted to make sure we were not having any problems. My daughter pointed out that she was not following other shoppers and then I had to tell her the bitter truth: There are things people will do to you and not to others, just because of your skin color.

People that act that way will not consider themselves racists. It is just ingrained in our society and people do it without giving thought to why they are doing it.

The African American male suffers the consequences of racial profiling in a proportion that is heart-breaking. Even with education and civility, it does not erase how they are being viewed and treated. My husband has a Ph.D. in Physiology and Anatomy, yet he cannot get a job to provide for his family. His job as a professor in Northern New Mexico College was terminated 6 years ago because of racial injustice. His students protested because they loved him, and he was a wonderful teacher that made the most difficult course easy to understand.

Peaceful protest of racial injustice is one way to overcome this evil. I was touched when I saw the variety of people protesting: white, black, yellow, red, young, old etc. It shows there is hope for humanity. Love is the way to extend it to our homes. What and how we talk, at our dinner tables, about other people different from us matter. Choose the love way. Explain to your family that even if people are different from you, they are humans and have the same basic needs you have.

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Letter To The Editor: Love Overcomes Hate - Los Alamos Daily Post

A Homeopathic Defence Against COVID-19 Is No Defence at All – The Wire

Arsenicum album 30C (Aa30C) is a homeopathic drug that Indias Ministry of AYUSH prescribed through an advisory on March 6, in the context of the COVID-19 pandemic. In section i. Preventive and prophylactic and sub-section Homoeopathy, the ministry advised the recommended dose thus: Arsenicum album 30, daily once in empty stomach for three days.

To make the drug, a mother tincture of the medicine is first made by dissolving by arsenic trioxide in a mixture of glycerine, alcohol and water or sometimes by heating arsenic with water. One millilitre of this tincture is diluted with 99 ml of water plus ethyl alcohol, and given a few machine-operated, moderate, equal and successive jerks, called succussions. This leads to a 100-fold dilution. The process is repeated 30-times to produce the final product, of 30C potency. A few drops of this, loaded on sugar pills, is administered to an individual. Apparently, each dilution plus succussion step makes the formulation more potent, and the process is called potentisation.

Starting with a mother tincture that has 200 grams of arsenic trioxide in 1 litre of liquid, the 30C potency medicine has one molecule of the active material present in a volume equivalent to that of 1 million Suns. In terms of the active material, an individual is consuming zero molecules.

However, this should not surprise us. Homeopathy was first proposed in Germany by Samuel Hahnemann (1755-1843) as an alternate medicinal strategy, more than 200 years ago. This was a time when the chemistry to show the above effect was not known (now it is in school textbooks). This was also an era where orthodox medicine was crude, often involving blood-letting. Compared to this, homeopathy seemed safe and humane. But today, when science has since made numerous strides, it is problematic that homeopathic principles still evade the rigours of scientific questioning.

From nothingness to water memory

Homeopathy takes recourse in the notion that water, when it comes in contact with the active material, develops molecular memory. In the absence of this active material in the final formulation, it is this memory-laden water that triggers an immune response in the human body. Note that the active material arsenic, in this case is chosen based on the homeopathic law of similars, i.e. a substance that induces the symptoms of a disease.

Unfortunately, there is no evidence of water having any kind of memory. Even the journal Nature was touched by this controversy. It should also strike us that if water remembered what it touched, it would have lots of memories of anything it touched.

Any scientific response to such lack of evidence should be rigorous experimentation to demonstrate effects, or the lack of it. However, the actual response to any critique of homeopathy has often been that science does not know everything yet.

The quest to explain how homeopathy works has also led to hypotheses that suggest the active material somehow survives in even the most dilute homeopathic medicines. Here, the original active material finds its way into the final drug via interaction of the drug and bubbles formed during succussions. However, the methods used in the study are not standard for potentisation. The physics of bubbles catching the active material is unclear, and control experiments like checking for contaminants were not performed.

More importantly, even if traces of active material are present, how do they trigger physiology to act against an external agent (like the novel coronavirus)? We dont know. For a chemical to be accepted as a drug, it takes years of experimentation, involving laboratory experiments, animal trials and human trials over multiple phases. But proponents of homeopathy have claimed that it cannot be subjected to such trials because it provides highly individualised doses. However, the mass distribution of Aa30C is anything but individualised.

Most popular narratives on homeopathy consist of anecdotes and scientific-sounding terms like vital force or biphasic actions. Hahnemann himself explained that homeopathy worked through a dematerialised spiritual force.

We also hear things like a thousand people were given this medicine and then 95% did not get the disease, so it works. This is not what a trial is and these experiments are worthless unless compared with 1,000 people who are given placebos (i.e. blank doses).

The fact that homeopathy thrives is not proof of its efficacy just like the existence of tarot readers and astrologers does not prove that these practices have any scientific basis.

Homeopathy puts on an aura of respectability thanks to scientific journals from major publishers that cater to it.

Many reputed institutions have looked at the available literature and their conclusions are unequivocal. The US National Institutes of Health say, Theres little evidence to support homeopathy as an effective treatment for any specific health condition. The UKs National Health Services (NHS) state, Theres been extensive investigation of the effectiveness of homeopathy. Theres no good-quality evidence that homeopathy is effective as a treatment for any health condition.

A report prepared by a committee appointed by the UK parliament in 2010 called the British governments position on homeopathy confused and recommended that the government stop funding homeopathy on the NHS. The report argued that homeopathy undermines the relationship between NHS doctors and their patients, reduces real patient choice and puts patients health at risk. Since 2017, the NHS has severely restricted access to homeopathy.

After an extensive literature survey, Australias National Health and Medical Research Council concluded in 2015 that there was no reliable evidence from research in humans that homeopathy was effective for treating the range of health conditions considered: no good-quality, well-designed studies with enough participants for a meaningful result reported either that homeopathy caused greater health improvements than placebo, or caused health improvements equal to those of another treatment.

Also read: Will COVID-19 Change AYUSH Research in India for the Better?

A false shield

A much-quoted statement by the WHO sometimes distorted during the Ebola outbreak in 2014 said, In the particular context of the current Ebola outbreak in West Africa, it is ethically acceptable to offer unproven interventions that have shown promising results in the laboratory and in animal models but have not yet been evaluated for safety and efficacy in humans as potential treatment or prevention (emphasis added). However, the words in bold are often omitted in public statements, such as in the AYUSH ministry advisory.

All the hype and publicity surrounding Aa30C have set the stage for people to desperately chase what they think is a wonder drug. Clarifications of the type issued by the AYUSH ministry, stating that their recommendation is only in the general context or that it is only for add-on preventive care, is like water off a ducks back. Panic-buying of Aa30C has already been reported. News of random, untracked distributions by various agencies and buyers flocking to pharmacies to buy the concoction at inflated prices continue to pour in.

The problem is significant because people are likely to believe that by imbibing this medicine, they have just acquired a shield against the COVID-19. A corporator in Mumbai mentioned that some people, when questioned about their being out during a lockdown, said that they had taken Arsenicum album. They believed that they would now be immune to the disease.

Anurag Mehra, Supreet Saini and Mahesh Tirumkudulu teach in IIT Bombay.

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A Homeopathic Defence Against COVID-19 Is No Defence at All - The Wire

Monsoon meals: Heres how to stay healthy with right foods for the season – YourStory

You might love the rains or hate the rainy season. Either way, the monsoon brings with it some dramatic changes to your physiology. If you know how to tweak your diet and lifestyle to cope with these external changes in the season, you can do a lot to support your body.

What matters is understanding the changes and learning to go with them. You need to remember that you always have to eat differently and live differently whenever the seasons change, in order for your body to move harmoniously through them.

The biggest impact to your body during the monsoon is that your digestion will not be the same. This thought needs to be at the root of all change.

This means that you need to change what you eat, so that you eat food that is easier to digest, both in terms of the food itself and in the method of preparation. You don't need to add any superfoods. I believe that superfoods only become superfoods when they are used in the right manner at the right time.

Begin your day with hot beverages and a warm breakfast during the monsoon

Now that you know these two things that you have to keep in mind about the monsoons, I want to actually explain how you can apply this to your diet and lifestyle.

Exercise is very important during the monsoon

Poha is both delicious and healthy for the rainy season

A good digestive tea can boost your immunity during the monsoon

Boil some ginger, a tablespoon each of coriander seeds, cumin seeds, fennel seeds and fenugreek seeds in two cups of water. Reduce the quantity to one cup. Strain and consume with your meal.

This is a simple tea which makes a world of difference to your digestion in the monsoon. Since your digestion is at the root of immunity, improving your digestion is the best way to support your health and prevent an infection this monsoon!

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Monsoon meals: Heres how to stay healthy with right foods for the season - YourStory

FAMILY MATTERS: Playing to the traits we are born with – Eagle-Tribune

Dear Doctor,

Our two young children are as different as daylight and darkness. While they are both still young, they are not alike at all.Our son is 8 and our daughter is 6. He is thoughtful and slow to speak or act. She, on the other hand, is talkative, quick to do what she wants, and knows her mind even when its not appropriate. Do behaviors come as inherited? Both children are ours, but we wonder where their differences come from.

Curious

Dear Curious,

Children come as their own package of likely behaviors.

There was a time in behavioral and educational theory that it was believed the mind was a tabula rasa (blank slate) on which could be writ whatever a parent ordained. That theory is not widely accepted today.

Think about it. As you consider your friends and neighbors, do you not have an amazing range of gifts and variability in behavior? Isnt this what makes our species so rich and different? All human behavior is on a curve. Some have less of a trait and others more. Many are average with one trait or another.

Trait psychology is here to stay. Any parent or grandparent will tell you children come with unique and sometimes welcome or unwelcome behavioral tendencies and styles.

For example, in the same family, one may see one child who is giving and unselfish. Another may make Scrooge look generous. Why? The unique inheritance of different neurologies and consequent traits results in variability. What would the world be without variance? It would be colorless indeed.

Now comes the troublesome part. Some traits are much less desirable than others. Thus, it is important to consider a basic trait and the life experiences of any person. The difference between a great artist and a destructive force is less than we might think.

How to enhance the positive and not reinforce the less desirable is, in my opinion, the consummate skill of an effective parent. That will be the topic of another column.

Dr. Larry Larsen is an Andover psychologist. If you would like to ask a question, or respond to one, email him at lrryllrsn@CS.com.

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FAMILY MATTERS: Playing to the traits we are born with - Eagle-Tribune

Achieving Provably Beneficial AI Is Demonstrably Vexing, Including The Case Of Self-Driving Cars – Forbes

Can AI be provably beneficial?

AI systems are being crafted and fielded at lightning-like speeds.

That seems on the surface to be a good thing.

But do we know that these AI systems are going to act in beneficial ways?

Perhaps among the plethora of AI systems are some that will be or might become untoward, working in non-beneficial ways, carrying out detrimental acts that in some manner cause irreparable harm, injury, and possibly even death to humans.

Yes, there is a distinct possibility that there are toxic AI systems among the ones that are aiming to help mankind.

In fact, we really do not know whether it might be just a scant few that are reprehensible or whether it might be the preponderance that goes that malevolent route.

One crucial twist that accompanies an AI system is that they are often devised to learn while in use, thus, there is a real chance that the original intent will be waylaid and overtaken into foul territory, doing so over time, and ultimately exceed any preset guardrails and veer into evil-doing (for my analysis of such AI possibilities, encompassing medical devices, self-driving cars, and so on, see this link here).

Proponents of AI cannot assume that AI will necessarily always be cast toward goodness.

There is the noble desire to achieve AI For Good, and likewise the ghastly underbelly of AI For Bad.

To clarify, even if AI developers had something virtuous in mind, realize that their creation can either on its own transgress into badness as it adjusts on-the-fly via Machine Learning (ML) and Deep Learning (DL), or it could contain unintentionally seeded errors or omissions that when later encountered during use are inadvertently going to generate bad acts (see more at this link here).

Somebody ought to be doing something about this, you might be thinking and likewise wringing your hands worryingly.

One such proposed solution is an arising focus on provably beneficial AI.

Heres the background.

If an AI system could be mathematically modeled, it might be feasible to perform a mathematical proof that would logically indicate whether the AI will be beneficial or not.

As such, anyone embarking on putting an AI system into the world would be able to run the AI through this provability approach and then be confident that their AI will clearly be in the AI For Good camp, and those that endeavor to use the AI or that become reliant upon the AI will be comforted by the aspect that the AI was proven to be beneficial.

Voila, we turn the classic notion of A is to B, and as B is to C, into the strongly logical conclusion that A is to C, as a kind of tightly interwoven mathematical logic that can be applied to AI.

For those that look to the future and see a potential for AI that might overtake mankind, perhaps becoming a futuristic version of a frightening Frankenstein (see my discussion about Frankenstein and AI at this link here), this idea of clamping down on AI by having it undergo a provability mechanism to ensure it is beneficial offers much relief and excitement.

We all ought to rejoice in the goal of being able to provably showcase that an AI system is beneficial.

Well, other than those that are on the foul side of AI, aiming to use AI for devious deeds and purposely seeking to do AI For Bad. They would be likely to eschew any such proofs and offer instead pretenses perhaps that their AI is aimed at goodness as a means of distracting from its true goals (meanwhile, some might come straight out and proudly proclaim they are making AI for destructive aspirations, the so-called Dr. Evil flair).

There seems to be little doubt that overall, the world would be better off if there was such a thing as provably beneficial AI.

We could use it on AI that is being unleashed into the real-world and then is heartened that we have done our best to keep AI from doing us in, and accordingly use our remaining energies on keeping watch on the non-proven AI that is either potentially afoul or that might be purposely crafted to be adverse.

Regrettably, there is a rub.

The rub is that wanting to have a means for creating or verifying provably beneficial AI is a lot harder than it might sound.

Lets consider one such approach.

Professor Stuart Russell at the University of California Berkeley, an AI luminary and notably at the forefront of provably beneficial AI, proposes in his research that there are three core principles involved (based on his research paper at this link):

1)The machines purpose is to maximize the realization of human values. In particular, it has no purposes of its own and no innate desire to protect itself.

2)The machine is initially uncertain about what those human values are. The machine may learn more about human values as it goes along, of course, but it may never achieve complete certainty.

3)Machines can learn about human values by observing the choices that we humans make.

Those core principles are then formulated into a mathematical framework, and an AI system is either designed and built according to those principles from the ground-up, or an existent AI system might be retrofitted to abide by those principles (the retrofitting would be generally unwise as it is easier and more parsimonious to start things the right way rather than trying to, later on, squeeze a square peg into a round hole, as it were).

For those of you that are AI insiders, you might recognize this approach as being characterized by being a Cooperative Inverse Reinforcement Learning (CIRL) scheme, whereby multiple agents are working in a cooperative manner and the agents, in this case, are a human and an AI, of which the AI attempts to learn from the human by the actions of the human instead of learning from the AIs own direct actions per se.

Setting aside the technical jargon, some would bluntly say that this particular approach to provably beneficial AI is shaped around making humans happy with the results of the AI efforts.

And making humans happy sure seems like a laudable ambition.

For those readers interested in more about Stuarts views, I highly recommend his quite readily readable book entitled Human Compatible: Artificial Intelligence and the Problem of Control.

The Complications Involved

It turns out that there is no free lunch in trying to achieve provably beneficial AI.

Consider some of the core principles and what they bring about.

The first stated principle is that the AI is aimed to maximize the realization of human values and that the AI has no purposes of its own, including no desire to protect itself.

Part of the basis for making this rule is that it would seem to do away with the classic paperclip problem or the King Midas problem of AI.

Allow me to explain.

Hypothetically, suppose an AI system was set up to produce paperclips. If the AI is solely devoted to that function, it might opt to do so in ways that are detrimental to mankind. For example, in an effort to produce as many paperclips as possible, the AI begins to takeover steel production to ensure that there are sufficient materials to make paperclips. Soon, in a draconian way, the AI has marshaled all of the worlds resources to incessantly make those darned paperclips.

Plus, horrifically, humanity might be deemed as getting in the way of the paperclip production, and so the AI then wipes out humanity too (for my detailed analysis of the AI paperclip problem, see this link here).

All in all, this is decidedly not what we would have hoped for as a result of the AI paperclip making system.

This is similar to the fable of King Midas whereby everything he touched turned to gold, which at first seemed like a handy way to become rich, but then upon touching water it turns to gold, and the food turned to gold, and so on, ultimately he does himself in and realizes that his wishes were a curse.

Thus, rather than AI having a goal that it embodies, such as making paperclips, the belief in this version of provably beneficial AI is that it would be preferred that the AI not have any self-beliefs and instead entirely be driven by the humans around it.

Notice too that the principle states that the AI is established such that it has no desire to protect itself.

Why so?

Aha, this relates to another classic AI problem, the off-switch or kill-switch issue.

Assume that any AI that we humans craft will have some form of off-switch or kill-switch, meaning that if we wanted to do so, we could stop the AI, presumably whenever we deemed desirable to so halt. Certainly, this would be a smart thing for us to do, else we might have that crazed paperclip maker and have no means to prevent it from overwhelming the planet in paperclips.

If the AI has any wits about it, which we are kind of assuming it would, the AI would be astute enough to realize that there is an off-switch and that humans could use it. But if the AI is doggedly determined to make those paperclips, the use of an off-switch would prevent it from meeting its overarching goal, and therefore the proper thing to do would be for the AI to disable that kill-switch.

In fact, it might be one of the first and foremost acts that the AI would undertake, seeking to preserve its own lifeblood by disabling the off switch.

To try and get around this potential loophole, the stated principle in this provably beneficial AI framework indicates that the AI is not going to have that kind of self-preservation cooked into its inherent logic.

Presumably, if the AI is going to seek to maximize the realization of human values, it could be that the AI will itself realize that disabling the off-switch is not in keeping with the needs of society and thus will refrain from doing so. Furthermore, maybe the AI eventually realizes that it cannot achieve the realization of human values, or that it has begun to violate that key premise, and the AI might overtly turn itself off, viewing that its own demise is the best way to accede to human values.

This does seem enterprising and perhaps gets us out of the AI doomsday predicaments.

Not everyone sees it that way.

One concern is that if the AI does not have a cornerstone of any semblance of self, it will potentially be readily swayed in directions that are not quite so desirable for humanity.

Essentially, without a truism at its deepest realm of something ironclad about dont harm humans, using perhaps Issac Asimovs famous first rule that a robot may not injure a human being or via inaction allow a human to be harmed, there is no fail-safe of preventing the AI from going kilter.

That being said, the counter-argument is that the core principles of this kind of provably beneficial AI are indicative that the AI will learn about human values, doing so by observation of human acts, and we might assume this includes that the AI will inevitably and inextricably discover on its own Asimovs first rule, doing so by the mere act of observing human behavior.

Will it?

A counter to the counter-argument is that the AI might learn that humans do kill each other, somewhat routinely and with at times seemingly little regard for human life, out of which the AI might then divine that it is okay to harm or kill humans.

Since the AI lacks any ingrained precept that precludes harming humans, the AI will be open to whatever it seems to learn about humans, including the worst and exceedingly vile of acts.

Additionally, there are critics of this variant of provably beneficial AI that are apt to point out that the word beneficial is potentially being used in a misleading and confounding way.

It would seem that the core principles do not mean to achieve beneficial in that sense of arriving at a decidedly good result per se (in any concrete or absolute way), and instead beneficial is intended as relative to whatever humans happen to be exhibiting as seemingly so-called beneficial behavior. This might be construed as relativistic ethics stanch, and in that manner, does not abide by any presumed everlasting or considered unequivocal rules of how humans ought to behave (even if they do not necessarily behave in such ways).

There are of course counter-arguments to the counter-arguments, seemingly ad infinitum. You can likely see that this topic can indubitably get immersed in and possibly mired into voracious philosophical and ethical AI foundations debates.

This also takes things into the qualms about basing the AI on the behaviors of humans.

We all know that oftentimes humans say one thing and yet do another.

As such, one might construe that it is best to base the AI on what people do, rather than what they say since their actions presumably speak louder than their words. The problem with this viewpoint of humanity is that it seems to omit that words do matter and that inspection of behavior alone might be a rather narrow means of ascribing things like intent, which would seem to be an equally important element for consideration.

There is also the open question about which humans are to be observed.

Suppose the humans are part of a cult that is bent on death and destruction, and in which case, their happiness might be shaped around the beliefs that lead to those dastardly results, and the AI would apparently dutifully learn those as the thing to maximize as human values.

And so on.

In short, as pointed out earlier, seeking to devise an approach for provably beneficial AI is a lot more challenging than meets the eye at first glance.

That being said, we should not cast aside the goal of finding a means to arrive at provably beneficial AI.

Keep on trucking, as they say.

Meanwhile, how might the concepts of provably beneficial AI be applied in a real-world context?

Consider the matter of AI-based true self-driving cars.

The Role of AI-Based Self-Driving Cars

True self-driving cars are ones that the AI drives the car entirely on its own and there isnt any human assistance during the driving task.

These driverless vehicles are considered a Level 4 and Level 5, while a car that requires a human driver to co-share the driving effort is usually considered at a Level 2 or Level 3. The cars that co-share the driving task are described as being semi-autonomous, and typically contain a variety of automated add-ons that are referred to as ADAS (Advanced Driver-Assistance Systems).

There is not yet a true self-driving car at Level 5, which we dont yet even know if this will be possible to achieve, and nor how long it will take to get there.

Meanwhile, the Level 4 efforts are gradually trying to get some traction by undergoing very narrow and selective public roadway trials, though there is controversy over whether this testing should be allowed per se (we are all life-or-death guinea pigs in an experiment taking place on our highways and byways, some point out).

Since semi-autonomous cars require a human driver, the adoption of those types of cars wont be markedly different than driving conventional vehicles, so theres not much new per se to cover about them on this topic (though, as youll see in a moment, the points next made are generally applicable).

For semi-autonomous cars, it is important that the public needs to be forewarned about a disturbing aspect thats been arising lately, namely that in spite of those human drivers that keep posting videos of themselves falling asleep at the wheel of a Level 2 or Level 3 car, we all need to avoid being misled into believing that the driver can take away their attention from the driving task while driving a semi-autonomous car.

You are the responsible party for the driving actions of the vehicle, regardless of how much automation might be tossed into a Level 2 or Level 3.

Self-Driving Cars And Home Deliveries

For Level 4 and Level 5 true self-driving vehicles, there wont be a human driver involved in the driving task.

All occupants will be passengers.

The AI is doing the driving.

One hope for true self-driving cars is that they will mitigate the approximate 40,000 deaths and about 1.2 million annual injuries that occur due to human driving in the United States alone each year. The assumption is that since the AI wont be driving and drinking, for example, it will not incur drunk driving-related car crashes (which accounts for nearly a third of all driving fatalities).

Some offer the following absurdity instance for those that are considering the notion of provably beneficial AI as an approach based on observing human behavior.

Suppose AI observes the existing driving practices of humans. Undoubtedly, it will witness that humans crash into other cars, and presumably not know that it is due to being intoxicated (in that one-third or so of such instances).

Presumably, we as humans allow those humans to do that kind of driving and cause those kinds of deaths.

We must, therefore, be satisfied with the result, else why we would allow it to continue.

The AI then learns that it is okay to ram and kill other humans in such car crashes, and has no semblance that it is due to drinking and that it is an undesirable act that humans would prefer to not have taken place.

Would the AI be able to discern that this is not something it should be doing?

I realize that those of you in the provably beneficial AI camp will be chagrined at this kind of characterization, and indeed there are loopholes in the aforementioned logic, but the point generally is that these are quite complex matters and undoubtedly disconcerting in many ways.

Even the notion of having foundational precepts as absolutes is not so readily viable either.

Take as a quick example the assertion by some that an AI driving system ought to have an absolute rule like Asimovs about not harming humans and thus this apparently resolves any possible misunderstanding or mushiness on the topic.

But, as Ive pointed out in my analysis of a recent incident in which a man rammed his car into an active shooter, there are going to be circumstances whereby we might want an AI driving system to undertake harm, and cannot necessarily have one ironclad rule thereof (see the link here).

Again, there is no free lunch, in any direction, that one takes on these matters.

Conclusion

Link:
Achieving Provably Beneficial AI Is Demonstrably Vexing, Including The Case Of Self-Driving Cars - Forbes

After the pandemic, an opportunity to ‘reset’ the Centro, say activists – Yucatn Expat Life

Newly arriving bars were bad neighbors for private residents who lived on the same block. Photo: Courtesy

One of the most important lessons from the pandemic is the importance of public health, and how our own behavior is a factor in preventing or spreading illness.

Thats the message from Todos Somos Merida, whose anti-noise campaign targeted the very nightclubs and bars that disappeared early on during the coronavirus lockdown.

This unprecedented crisis offers us the opportunity to reinvent ourselves, point out members of the citizen collective.

As the economy slowly reopens, Todos Somos asks society to reflect on actions aimed at achieving a sustainable balance between business activity and community health.

Today the main issue is the health emergency. Isolation, quarantine, social distancing, deprivation and economic loss are recurring themes in the media, along with phrases such as reflection time, raise awareness, moment of introspection, opportunity for change, time to rebuild ourselves,' reads an open letter from the anti-noise group.

Despite good intentions creating a dynamic city center residents lost sleep because bar owners have been allowed to dominate city blocks with loud music. Complainers were derided as entitled expat retirees with unrealistic expectations of living in a compact downtown. But Todos Somos is made up of local residents, many raising families in neighborhoods that were quiet before former homes were allowed to be converted into all-night party palaces.

When the coronavirus crisis forced an economic shutdown, bars and cantinas were the first to be shuttered, and the Centro returned to the quiet atmosphere it was known for until about five or six years ago.

Now, after this world event, we would like to ask if this mandatory strike really gives us a guideline for an opportunity for change and reconstruction in the area, Todos Somos wrote.

It is necessary to cement these ideas in practice to see if the shutdown is truly a reset and a new beginning that prioritizes sustainability and public health.

Vaccines, drugs and medical care are not enough.

We have learned that a determining factor is human behavior. How are we going to take care of ourselves? How are we going to regulate ourselves? How do we go from an I to a we? wrote Todos Somos. The pandemic has reminded everyone of their vulnerability.

It is vitally important that merchants and business owners involved in the economic revival of what we would like to call the New Historic Center question their practices and assess the impact of their behavior and activity on the health of people in and around their businesses or companies, the group further wrote.

After this experience, we should not go back to previous ways The best vaccine seems to be education and re-education. Values such as respect, solidarity, ethics, regulation and harmonious coexistence, must be put into action.

As its members have clarified several times, the movement is not against bars or against nightlife. What they are asking is that entertainment places that play music be soundproofed for a peaceful coexistence with neighbors who sleep at night.

A balance must be struck between the development of the economy and the health of the inhabitants, the open letter concludes.

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After the pandemic, an opportunity to 'reset' the Centro, say activists - Yucatn Expat Life

Study: Preschoolers Who Have Bad Relationship With Mom Grow Clingy With Teachers – Study Finds

NEW YORK Its important for a young child to have a caregiver who they trust and feel they can depend on. So it makes sense that a new NYU study finds that preschoolers who have a poor relationship with their mothers tend to develop dependent or clingy relationships with their teachers.

Additionally, researchers also say that as children who are disconnected from their parents grow older, they usually become anxious, withdrawn, and shy in elementary school.Although, it appears that a strong enough connection with a teacher from an early age can greatly help certain children avoid developing overly anxious or shy traits later on in adolescence.

Our research suggests that preschool teachers have the potential to play a pivotal role for children who are more dependent, says Robin Neuhaus, lead researcher and doctoral student in NYU SteinhardtsDepartment of Teacher and Learning, in a university release. By being warm and supportive, and by encouraging children to explore, preschool teachers may be able to reset the trajectories of children who may otherwise struggle with anxiety in elementary school.

Using data collected by the National Institute of Healths Eunice Kennedy Shriver National Institute of Child Health and Human Development, the research team analyzed 769 children from all over the United States.

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The relationship between each examined child and their mother was closely investigated. More specifically, mother and child attachment patterns were assessed. The participating children and their mothers were followed up with periodically throughout the childs life. First, at 36 months old, then at 54 months old, then during the first, third and fifth grades.

A number of relationship elements were assessed between a mother and her child, including closeness, dependency, and conflict. Those same elements were also measured between the children and their teachers.

Results from multilevel models showed that clingy behavior with preschool teachers was associated with higher levels of anxious behaviors when children were in fifth grade. Clingy behavior also partially mediated the link between a difficult type of mother-child attachment and anxiety in fifth grade, Neuhaus concludes.

The study is published in Attachment and Human Behavior.

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Study: Preschoolers Who Have Bad Relationship With Mom Grow Clingy With Teachers - Study Finds

Cash transfers to the poor linked to ecological benefits – The Hub at Johns Hopkins

ByChanapa Tantibanchachai

In a new study, researchers recently discovered that Indonesia's national anti-poverty program reduced deforestation by about 30%.

The study's findings were published today in Science Advances.

"Two of the great global challenges of the 21st century are to reduce poverty and slow deforestation. Unfortunately, the solutions to those challenges are often perceived as conflicting with each otherprogress on one front means retreat on the other," says Paul Ferraro, Bloomberg Distinguished Professor of Human Behavior and Public Policy at the Johns Hopkins University and the study's first author.

Paul Ferraro

Bloomberg Distinguished Professor of Human Behavior and Public Policy

The study is the first of its kind to suggest that cash transfers to communities in poverty can positively affect forest conservation, says the study's co-author, Rhita Simorangkir, a Research Fellow at the National University of Singapore.

"In other words, reducing poverty does not have to create unavoidable environmental costswe can make progress on both fronts," Simorangkir says.

Biodiversity and deforestation are disproportionately located in regions with high levels of poverty; for example, Indonesia is among the top ten biodiversity hotspots with the greatest area impacted by poverty. Indonesia also has the third-largest area of tropical forest and one of the highest deforestation rates, making it a strong study choice with findings that could be applied to other countries.

In the past, researchers only examined connections between poverty and the environment on the macroeconomic or local scales, says Ferraro. However, these studies are limited because they don't allow researchers to clearly establish a link between specific poverty interventions and environmental impacts.

A clear link would be significant, the researchers say, because so much international and philanthropic aid is aimed at programs to alleviate poverty. If evidence shows that such aid can also benefit the environment, global leaders would have new considerations for budget allocations and environmental goals.

For this study, Ferraro and Simorangkir studied Indonesia's national anti-poverty program, Program Keluarga Harapan, which provides poor households with conditional cash transfers. The team reviewed data from 7,468 rural forested villages exposed to the program between 2008 and 2012, totaling 266,533 households that received cash. To estimate the program's causal effect on deforestation, Ferraro and Simorangkir combined data on annual forest cover loss and data on how the program was phased in across villages, along with methods that help isolate the program's effect on forests from all the other factors that also affect forests.

The authors estimated that the anti-poverty program reduced deforestation in participating villages by 30%, with roughly half of those avoided losses in biodiverse primary forests. Their findings also show that reductions were larger when more villagers received cash transfers and when a village participated for more years.

The authors say the anti-poverty program seems to reduce deforestation because cash provides recipients with a sort of insurance alternative to deforestation (i.e. poor farmers now have money to support themselves instead of deforesting more land when bad weather threatens to lower yields). The program also allows recipients to buy products on markets rather than obtain them by clearing forests, they suggest.

"Other studies have shown that Indonesia's program indeed lifted people out of poverty," Ferraro says. "But even if it had not done so, its environmental benefits are valuable. In fact, the economic value of the avoided carbon emissions alone compares favorably to program implementation costs. Similar programs in other countries should be evaluated in the same way, but if what we found in Indonesia generalizes to other biodiverse nations, it would provide some hope that global efforts to eradicate extreme poverty and reverse the loss of biodiverse ecosystems can be complementary."

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Cash transfers to the poor linked to ecological benefits - The Hub at Johns Hopkins

Keep the Faith: The pandemic is not Gods punishment – Worcester Telegram

I was listening to the news on the radio the other day and there was a particular segment on opening churches and religious freedom that caught my attention. An enthusiastic proponent of opening churches was being interviewed and in the course of making his point he said something like: the Egyptians were visited by plagues and they didnt succumb, but toughed it out. I did a double take. (Can you do a double take if its a voice on the radio?) Regardless, I said to myself, hes misread the whole story. In fact, I wonder if he really knows the story at all.

Lets go to the Bible. For the sake of brevity, Im going to zip through big parts of the story in order to focus on what I think are the take-away points for us in this instance.

God uses the betrayal of Joseph by his brothers to bring him to Egypt. He has a plan for him. There, through Gods gift, he interprets for Pharaoh the dreams that had been disturbing him. Then Pharaoh entrusts Joseph with managing and preparing for both the seven years of plenty, and the seven years of famine, foretold in his dream.

In gratitude, Pharaoh invites Jacob, Josephs father, Joseph's brothers and their families, and the Israelites to settle in Egypt. They prosper and grow. Over time, the memory of Joseph fades. The Egyptians decide to exploit and then enslave the children of Israel. And so, God sends another deliverer: Moses.

Moses is sent to rescue his people from this slavery, and demands from Pharaoh that he allow them to leave Egypt. Pharaoh refuses, so God decides that he will persuade him, through Moses. His persuasion technique? The plagues.

God visits the plagues on Egypt, on Pharaoh, not to punish, but to alter their behavior, to get them to repent. Yes, they endured each of the plagues, one more terrible than the other, but after a brief repentance, they reverted to their original hard-heartedness. Even after the last terrible plague of the death of the first-born, they reverted and were determined to bring the Israelites back to Egypt, back to slavery. The Egyptians wanted their old life back again. And so, they pursued them even into the Sea turned dry land, and then God allowed the waters to cover them over.

No, the Egyptians did not overcome the plagues. No, they didnt really tough it out. They refused to accept what God was trying to teach them and suffered the consequences. It wasnt punishment, it was the obvious result of their unwillingness to learn. So, if one is going to take up lessons from the Bible, one might first need to read the Scriptures a little more carefully.

What any trial or crisis elicits is the hidden strengths or weaknesses in a person or community or nation. This particular crisis, this pandemic, is such a test, on steroids. We are seeing expressions of what is best in us in the sacrifice of countless people who are putting themselves, and often their loved-ones, at risk to help others. We are also seeing what is weak and even selfish in us by wanting our life back without yet fully appreciating what it was that got us here in the first place; by blaming others while ignoring what we ourselves need to do, in a word, repent. The pandemic is not Gods punishment, but perhaps he is using it to persuade us to change the way we treat one another and his creation.

The Exodus event has much to teach us. I would urge you to pick up your Bible and read it over from the second half of Genesis through the Book of Exodus and see how the children of Israel responded to their new-found freedom. Also, see the lessons God had for them as well. It turns out that the Egyptians are not the only ones afflicted with a prideful hard-heartedness.

I'd urge you to study the lessons in the Exodus. Like much of Scripture, it's replete with examples of human behavior and God's love that we can learn from. Christians see in this great story a precursor, a foreshadowing, of the salvation God would bring humanity in the coming of Jesus Christ. In most languages Christians call Easter: "Passover," (something we lose in English). The first Passover points to the second. In both Feasts we learn that true freedom, true liberation comes when we listen to God and strive to do his will.

The Rev. Nicholas Apostola is parish priest at St. Nicholas Orthodox Church in Shrewsbury

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Keep the Faith: The pandemic is not Gods punishment - Worcester Telegram