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The Thing Thats More Effective For Personal Growth Than Any Personality Test – Forbes

The recent season premiere of the Showtime seriesBillionsbegins with two hedge fund guys doing ayahuasca with a shaman in the middle of nowhere. We see them run out of the tent to purge, then look at the sky and take in the majesty of Planet Earth and the Universe it spins through. These guys who normally behave like the human offspring of a Hammerhead Shark and a Bloomberg Terminal have grown scraggly beards. Theyre openly weeping and talking about the meaning of things like life.

Five minutes of screen time later, theyre clean shaven and back in New York, doing insider trading and plotting to destroy people simply for being more popular than they are.

For a glimmer, it looked like these two aggressive, egomaniacal characters were on the brink of personal growth. Whatever experience they had in the mountains with the shaman had altered their perspective on things. It looked like they were ready to turn over a new leaf.

And then they didnt.

They went home, right back to who they had been before.

Billionsis fictional. But its writers are known to do their homeworkand do it well by television standards. What happened to those hedge fund guys isnt only a common occurrence when it comes to ayahuasca. Its also a dramatized version of what happens to most human beings in a small way all the time.

Research is clear that humans have the capacity to grow and change, no matter how old we are. Studies on post-traumatic growth show us that most of the time, we have the capacity to grow stronger and wiser as a result of even the worst experiences.

But we often DONT grow and change much after we become adults. Or at least not deliberately.

Why is that?

In a fascinating new self-help book by Dr. Benjamin Hardy, an organizational psychologist, we learn that one reason we dont grow when we have the chance to is because of the LABELS we place on ourselves.

Labeling is problematic because we think the label we give ourselves is predictive of the future, Hardy told me in an interview. "But we usually underpredict how different we'll be in the future.

This is why Dr. Hary says to beware of personality tests. Understanding yourself is great, but fixing a personality label on yourself can prevent you from growing. To use one of the most common examples of personality traits we talk about: if a test labels you an introvert, youre going to be likely to make decisions that reinforce that. You'll be less likely to do activities that grow your ability to perform in front of a group of peoplesay, to practice public speaking. You'll actually be more likely to avoid extroversion experiences because you come to believe introversion as part of your unchangeable core.

Personality Isn't Permanent

But research is clear that peoples personalities do evolve. Even levels of introversion change over the years. Perhaps more importantly, they vary from situation to situation. Many an outgoing public speaker is shy in personal conversations with strangers.

Even though humans can and do change, we often change slowly, or we dont take charge of our growth because we mistakenly believe our traits are fixed.

The Billions hedge fund guy doesnt change as a result of his "transformative" experience not because he cant, but because he sees himself as fixed. He's a shark. Thats just who he is. So, oh well.

Same with us. When we have experiences that change our perspectives, instead of changing things in our lives, our subconscious brains often mistakenly say, tigers dont change their stripes. And so we go back to our old behaviorsno matter how bad they are.

The problem with this is right in the title of Dr. Hardys excellent new book:Personality Isnt Permanent.

Had the fictional billionaires inBillionsdone one thing, however, things might have actually changed in that story.

The difference between people who go on, say, an ayahuasca journey and then change their life and those who dont comes down to whats called integration.

This is the time you take after the experience to reflect on your life and to incorporate any new perspectives into it. Its figuring out practical daily applications to profound life experiences. Plant medicine workers often say that this step is just as important as the experience itself.

For those of us that arent regularly using psychedelic substances, were still having regular experiences that we can be learning from.

The difference between personal growth in either casewhether were talking about the aftermath of ayahuasca or a documentary, or even a conversation with someoneis whether you integrate what youve learned into your life, and are able to apply it.

The kinds of people who consistently have personal growth are the ones who take the time to continually re-assess things in their lives based on the experiences theyre having all the time.

It takes intellectual humility to realize that we could be behaving differently and living better as a result of what weve learned. But thats why intellectual humility is so powerful.

All progress starts by telling the truth, Hardy says, quoting Dan Sullivan, And thats a big aspect ofpsychological flexbility, or being able to look at something from a different anglea willingness to actually handle emotion and to face hard truths.

The reason we don't do proper integration in our lives often boils down to the labels thing. We don't take time for integration because we don't think we can change. But knowing that even traits we view asfundamentalcan and do change gives us a reason to do what Bobby Axelrod didn't.

And it turns out that theres a very easy way to incorporate regular integration into our everyday lives: Write in a journal.

Journaling is the ultimate integration tool, Hardy explains. Theres something magical about giving yourself the time to think about your past in light of what you now know, and to write it down.

Now, wehuman beings are good at deception. And were good at lying to ourselves. But were much more likely to be honest with ourselves when we put our thoughts into words in a journal meant for only ourselves than we are with our friends, or sometimes even with a therapist.

And for journaling to be effective, you dont even have to do it every day. Just whenever you have a potentially meaningful experience.

Journaling is a form of clarifying thoughts and emotions, Hardy told me. Its a place where you can have healthy conversations with yourself where you can be vulnerable and honest about what youre actually going through. Its a place for self-analysis about whats generally going on in your life.

(I can attest personally to the power of journaling for my own personal growth. If you want to read about the time I started keeping a lie journal about my white lies and how that changed my relationships, as an example of a specific outcome from journaling,I wrote about that in my personal newsletter a bit ago here.)

When you force yourself to think about your life, and put into words how your recent experiences might help you to change, the concept of personality starts to become less interesting than the concept of strengths. Taking self-inventory in terms of strengths and weaknesses is a lot more useful and actionable than taking inventory of yourself like a tiger taking inventory of its stripes.

Journaling and self-analysis can help us to reframe fixed labels as current strengths and weaknesses. Instead of stopping at Im an introvert or extrovert we can ask, How good am I at going deep into introspection? How good am I at conversations with strangers? At public performance? At asserting myself? At being alone? This way, we start to see introversion and extroversion as categories of strengths we can work on, not either/or labels that dont change.

The takeaway from Dr. Hardys research on self-development is not to replace the study of human behavior with journaling, or to throw out decades of research on personality with the bathwater of labels and bad tests.

Anyone whos had more than one kid will tell you how useful it is to know how what gets one kid to clean their room is different for the other.

Indeed, understanding personality diversity is incredibly important to communicating effectively with people, to resolving problems, to persuasion, to building coalitions. As Dr. Hardy told me, My book is not really tailored to the question of how to deal with other people based on their personalities.

But, as Hardy rightly points out, even the most scientifically sound personality tests cant really tell us what will motivate someone in a given situation, what triggers a person will have due to past experiences, or how someone will tend to react to bad news. All of those will depend on much more than what we can measure with a test. (I dare you to find a parent who has used a one-time personality test to actually figure out the nuances of their kids.)

So while understanding the dimensions of human personality is useful for understanding human behavior, and can make us better equipped to notice people and show empathy, the best way to understand an individuals personality is not a multiple-choice quiz. Its to get to know their individual story.

And in a way, this brings us back to journaling. Because what better way to understand your own story than to take time to honestly think about it and put it into words?

The more you get to know someone, the more nuance there is, the less theyll be consistent with tight and tidy personality profiles, Hardy told me. I prefer the simplicity of looking at the individual level. And thats why I think empathy is so importantnot judging people based on who they were in the past.

The key, in other words, is to not conflate our observations of how people tend to behave with who they areand to remember that people change all the time.

In fact, if we treat people as if they can change for the better, people will often do so. Ourselves included.

Shane Snow is author ofDream Teamsand creator ofSnow Academy.

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The Thing Thats More Effective For Personal Growth Than Any Personality Test - Forbes

Joplin Health Dept. responds to national article predicting area as COVID-19 hot spot – KoamNewsNow.com

JOPLIN, Mo. It seems like the more you go out, the fewer masks you see, even as cases increase in the area.

It dont really scare us. We dont really take it with a grain of salt. We understand that people are getting sick, but we arent gonna let it control our lives, said Debbie Harris, one Joplin resident.

A lot of people feel that way, but there are others who are concerned about the rising numbers in Joplin and Jasper County, taking extra precautions to protect susceptible ones in the community.

I live with my grandparents and so I, when I came back, I spent like a couple months distancing from them and Ive even gone out of the way to like living in a studio, explained Anthony Azzun.

A New York Times article listed Joplin as a potential hot spot for an outbreak with an 11% growth rate and cases listed as doubling every 6.5 days, but, the Joplin Health Department wants to clarify that these numbers include cases from surrounding counties.

Just knowing the increase in the number of cases that weve seen as Joplin, Jasper, Newton, McDonald, this whole region in here going into Southeast Kansas and Oklahoma, as well, Im not surprised by it. Our workload in the last couple weeks has just exploded, said Ryan Talken with the Joplin Health Dept.

While Joplin is reporting 58 total cases: 22 active and 101 in quarantine, Jasper Countys latest numbers show a total of 259 with 210 in isolation, and over 750 on quarantine.

As we have more cases, contacts spin off of those cases and so those contacts end up getting tested, testing those contacts that were exposed, a lot of those are coming back positive, said Talken.

With the increasing case load, Talken says its more important than ever to take precautions.

Human behavior spreads it and we know what it takes to slow it down to prevent it.

The Jasper County Health Department says that the majority of cases are clustered around the Carthage area. If youre sick, health officials strongly encourage you to stay home.

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Joplin Health Dept. responds to national article predicting area as COVID-19 hot spot - KoamNewsNow.com

Rising temperatures could pose threat to spread of coronavirus – WJTV

Posted: Jun 19, 2020 / 01:10 PM CDT / Updated: Jun 19, 2020 / 01:10 PM CDT

RIDGELAND, Miss. (WJTV) During the early stages of the coronavirus pandemic, it was highly believed the heat could possibly help stop the spread of the virus. However, researchers say that is not enough.

Dr. Timothy Quinn of Quinn Healthcare explained the recent findings.

More researchers have added that humans have so little immunity to the virus. This is a new virus, so most of us have not been exposed. Our immune systems have not created enough antibodies, and then we dont have the vaccine, he said.

Health experts are still encouraging people to wear face masks and social distance.

I cannot overemphasize how important it is that we wear those masks. Human behavior has a very significant impact on the decrease spread of this virus, that includes social distancing, wearing a masks, washing your hands. Just following those guidelines that are suggested by the CDC, said Quinn.

Quinn also urged coaches to keep athletes hydrated as summer practices begin to kick-off across Mississippi.

Drink water before practice, during practice, after practice. Try to cut the hours or the time of practice to shorter intervals and try to practice during the cooler times of the day, such as early in the morning or later in the evening as much as possible to keep these young people safe.

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Rising temperatures could pose threat to spread of coronavirus - WJTV

Syncing Data And Creative: Advertising’s Head And Heart – Forbes

Within advertising, a debate has raged for years about how to balance advertisings head (data, sales goals and competitive share) and its heart (evoking peoples emotions, touching peoples souls, creating inspiration and wonder).

The past decade has swung the pendulum heavily toward the head; as an industry, we have focused on first-party audiences, data lakes, programmatic pipes, return on ad spend and a grim determination to map every impression to a sale. In that march toward advertising determinism, we have worked to bring creativity to heel by connecting creative teams to centralized platforms that map consumer insights, journeys and behaviors to inform the creative process. Yet, the magic formula for A=B/C= a campaign that performs every time hasnt emerged from all this effort. Why not?

Maybe its because there is no magic formula and there never will be. Im reminded of Economics 101 classes where every problem begins with assume a perfect market, even though a perfect market doesnt actually exist. In advertising, weve tried to create a perfect market by:

1. Relying heavily on big longitudinal datasets that cluster people in high-level buckets that, while often accurate, dont capture a lot of nuance.

2. Building one size fits all creative assets where what gets put in a mobile ad, for example, is often a cut-down version of a 30-second television spot, rather than an asset created for a unique channel and user experience.

3. Creating an artificial divide between brand and demand, where a given channel or campaign or creative is designed for one purpose or the other and measured accordingly.

What if, instead, we embraced our imperfection? What if we made room for head and heart in every initiative and measured things accordingly? What if we acknowledged that we are humans selling to humans, and that there is alchemy in what we do that can be optimized and improved upon but not mass-produced?

I am not suggesting a return to the Mad Men era of The ad will work because the creative director said it would work. Im suggesting we all lean into the future where the agile and atomized use of data brings both head and heart to everything we do.

Think about how companies such as Spotify, Netflix and Amazon make use of data to customize content and help us navigate an endless sea of options. These companies generate massive amounts of data, but they apply it in real time to customize peoples experience, and they use a feedback loop to continuously improve outcomes. What if all advertising could be that responsive and intelligent? Wouldnt that improve both customer experience and ROAS?

As the general manager of analytics at an attention analytics company, I believe the future isn't as far off as some might think. But it does require some behavioral and infrastructure shifts in marketing behavior. Among them are:

1. An approach to ad measurement that includes human behavior signals. At my company, we call these signals digital body language, and we use them to understand how an ad is being received by the person to whom it is being served.

2. A data infrastructure that is agile and flexible enough to capture, process and react in real time so that advertisers and their partners can not only see whats happening, but also set up responses that adjust messaging, imagery and offers within a campaign and even within a given users session.

3. Creative assets that are uniquely formatted to capture the signal and optimized to the channel in which they are being served so that winning narratives can be more easily recognized and optimized quickly.

4. A relentless test-and-learn mindset that embraces atomizing each piece of the ad experience to identify the colors, images, headlines and offers that drive results, both individually and working together.

Embracing head and heart requires teams to have a healthy respect for both data and creative and to begin to truly unpack how data, creative and media interact to deliver meaningful consumer experiences. Doing that requires a true spirit of partnership that allows everyone to fail fast, regroup, learn and try again.

While advertising might be a gloriously imperfect science, by letting our heads develop the right data infrastructure to give us valuable and actionable real-time insights and letting our hearts focus on the big ideas that connect and inspire us, we can embrace that imperfection to drive better business results.

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Syncing Data And Creative: Advertising's Head And Heart - Forbes

The cost and hidden silver lining of COVID-19 misinformation – WHYY

This story is from The Pulse, a weekly health and science podcast.

Subscribe on Apple Podcasts, Stitcher or wherever you get your podcasts.

Since the coronavirus shutdowns began, social media has become more important than ever. Its a lifeline to our old lives a way to stay connected with loved ones, to hear the latest news, and sometimes to try to forget whats happening altogether.

But theres a downside to all this. Case in point: Plandemic, a documentary-style conspiracy video that recently went viral.

In case you missed it, Plandemic features discredited scientist Judy Mikovits making unsubstantiated, and often bizarre, claims about the ongoing pandemic including that COVID-19 was manipulated in a lab, that National Institute of Allergy and Infectious Diseases director Anthony Fauci had profited from some kind of cover-up, and that wearing masks is actually making people sicker.

Facebook and YouTube scrambled to take the video down, but over just a few days it managed to rack up millions of views and tens of thousands of shares.

As it turns out, Plandemic is just the tip of the iceberg when it comes to a problem thats spreading even faster than the coronavirus something U.N. Secretary-General Antnio Guterres recently called an infodemic.

This is a time for science and solidarity, Guterres said in a video message. Yet the global mis-infodemic is spreading. Harmful health advice and snake oil solutions are proliferating; falsehoods are filling the airways; wild conspiracy theories are infecting the internet. Hatred is going viral, stigmatizing and vilifying people and groups.

Youve probably heard a few of them for instance, that the coronavirus was created by Bill Gates, or is being spread by 5G radio waves, or can be cured by drinking bleach. In that sense, theres a very good chance that social media helped shape how the pandemic has unfolded, and not in a good way.

But the opposite is also true: The coronavirus has helped researchers learn a lot about how social media work as vectors for misinformation. And its even started to push real change for example, Twitters latest move to start fact-checking false claims about COVID-19 (including ones that come from the president.)

Heres what researchers have discovered so far.

Fake news is nothing new, but the recent tsunami of misinformation surrounding COVID-19 is arguably unprecedented in its scope and persistence. What is it about the coronavirus that seems to have tripped this giant worldwide game of Telephone?

According to Kate Starbird, a professor at the University of Washington and co-founder of the Center for an Informed Public, its not as unusual as you might think.

Rumors are actually a typical part of a crisis event, Starbird said. Its natural human behavior.

Thats because humans crave information in the wake of crises, Starbird said information that could be crucial to their survival, such as which services have been affected, which roads are blocked, and where they can go for help.

And so under those conditions, what we as humans do is we try to resolve that uncertainty and that anxiety, she said.

The way we do it is by talking to one another.

We try to find that information and come up with explanations, Starbird said. And those explanations, we talk about it as collective sense-making.

Those explanations can be right, but they can also be wrong. When theyre wrong, the result is rumoring.

Historically, sense-making has happened on a local level but thanks to social media, our collective hunt for information about COVID-19 has turned into a worldwide conversation.

Its truly global, said Kathleen Carley, a professor of computer science at Carnegie Mellon University who also runs the Center for Informed Democracy and Social Cybersecurity. So that means people around the globe are spreading disinformation and it will get picked up by people in other countries.

Usually, disaster-related rumors start dying away as more questions are answered. But that hasnt always been the case with the coronavirus, thanks to ongoing uncertainty about how it works, where it came from, how to treat it, and what governments are doing about it. As the rumor mill churns, these germs of misinformation have continued to spread, as fast if not faster than a real virus.

The problem is, we cant exactly social distance on social media.

Its hitting at this moment where our information systems are already sort of characterized by persistent, pervasive misinformation, disinformation, and the strategic manipulation of these online spaces, Starbird said.

And even though were all facing the same threat, were not all coming at it from the same perspective. There can be miscommunications from one language to another, and even intentional deception between groups that dont have each others best interests at heart.

From all parts of the world, people can be exploiting other people right now, Starbird said. So its just really this kind of perfect storm.

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The cost and hidden silver lining of COVID-19 misinformation - WHYY

It takes teamwork, to both get the job done and take a break from the job – ThePrint

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People are feeling burned out. Months of uncertainty, homeschooling and strangely hard-to-decline video callshave taken their toll. Perhaps youve lost your ability to focus at work, and you cant even muster the motivation to care. Maybe you just feel really, really tired. Theres a natural impulse to blame this malaise on a very obvious aspect of the new circumstances many of us are facing: technology-enabled isolation amid a global pandemic and a barrage of heartbreaking news.

We struggle tostop rage-scrolling social media, but the news there has been so troubling that it feels wrong to look away. Nonstop video calls areexhausting, whether they are work meetings or virtual happy hours. Teleworking has its upsides, but one drawback is that it can be hard to switch off. The data show that each day, were working longer hours aboutthree hours longerthan we were before offices closed. Being separated from our bosses creates pressure to reply to messages instantaneously, to prove were not goofing off. Even after hours, our phones whisper about emails unread and buzz with messages from hyperactive group chats.

Most of the solutions on offer feelflimsy in comparison: Useenvironmental cues like clothing and locationto signal to your brain when youre working from home and when youre simply at home. Avoid the anxiety of late-night Twitter by leaving your phone outside the bedroom. Manage the unending email deluge with any number ofhacks and tips. When all else fails, take a few mindful breaths.

Somehow, such efforts dont really feel commensurate to the moment if they ever did. And although theres something to be said for steps you can take without consulting anyone, the most effective changes are those you make jointly with others your team, your boss, your family.

That was one lesson learned by the employees studied by Leslie Perlow, a professor at Harvard Business School. In her research, teams of exhausted consultants sought to regain work-life balance by ensuring that every team member could take predictable time off. To hold themselves accountable, they made that unplugged time mandatory. Working toward this goaltogetherwas ultimately what produced happier, less-burned out employees. It also improved communication between team members and resulted in higher-quality output for clients.

Collective action is the only way to re-establish healthy norms for communication technology. If your whole team spends the weekend emailing each other, it doesnt do much good for one person to take adigital sabbath. Emails will continue to fly, and the person who opted out unilaterally will miss important decisions or be tarred as a slacker, or both.

Instead, decide as a group when everyone needs to be online and when responses arent expected. You should also decide on how to communicate during off hours. Checking email during your leisure time is one of those annoying habits that can suck you back into work when you need to be doing something else. So choose, collectively, to reserve email for non-timely messages and to handle emergencies over the phone. That takes the pressure off of everyone to keep checking their inboxes just in case.

New norms can also help during work hours. You and your team could decide to keep one day a week free of meetings and, to the extent possible, messages, so that everyone can focus on heads-down work this is much easier to do without the pressure to respond to every email, slack or IM. Again, thissolution is best adopted jointly: If youre blocking out Fridays as a meeting-free day, but Juan chooses Mondays and Tina chooses Wednesdays, thats obviously not going to work. Instead, agree on one (or even two!) days a week and work together to keep them clear.

Of course, these techniques can also make a difference in your social and familial communications, since were often using thesame tech tools to talk with friends and family. If multi-hour, 10-person Zoom bonanzas are starting to wear you down, is that because of some problem inherent in Zoom, or because certain participants dont recognize when their stream of consciousness has run its course? Either way, its a tech-enabled problem that can be solved through human behavior agreeing to limit the conversation to an hour, appointing someone to moderate it, or bowing out of the mega-call and catching up with people one on one, over the good ol fashioned telephone.

Joint solutions like these emphasize that the burnout were experiencing isnt our problem to solve alone and isnt the inevitable result of our situation or technology. Its just how were wired.

Keeping up with information and not wanting to disappoint people arecommon human traits. A quick look back at history shows just how persistent these urges are, regardless of what technology is being used. When the printing press was invented, for example, anxiety aboutinformation overloadspiked Is there anywhere on earth exempt from these swarms of new books? Erasmus despaired,in 1525. Weve long felt besieged by correspondence: In 19th century London, letters could be deliveredup to 12 times daily; same-day delivery (and near-instant replies) were expected.

Working from home may feel new to many of us, but it too has a long history. In fact, as my colleague Justin Fox has pointed out, work-from-home rates arestill lowerthan they were in the 1960s.

Always-on technology and remote work didnt create burnout, but they can make it tougher to break free from it. When the usual barriers keeping work and other commitments in their place are gone, more human effort is required to contain them. Let that be ateam effort, and its much more likely to succeed.- Bloomberg

Also read: When work moved home during Covid, so did toxic workplace harassment

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It takes teamwork, to both get the job done and take a break from the job - ThePrint

You put yourself at risk, but thats the job: Fall River doctor on front line of coronavirus fight – Fall River Herald News

FALL RIVER For weeks, Dr. Daniel Sousa slept in the she shed. Then he moved into the sunroom. But now the physician who has been on the front lines of treating COVID-19 patients is back in the house and ready to enjoy Fathers Day with his family.

The father of three children, daughter Scarlet, 8; sons Skiler, 12, and Sidney, 14, said his wife, Theresa, a stay-at-home mom, has been doing double duty as teacher since the schools closed, while hes been focused on treating COVID-19 patients.

Though its been a challenge he never imagined when he decided to become a pulmonologist and its far from over the first couple months were filled with uncertainty, recalled Sousa.

As one of the partners with Southcoast Health Pulmonary, Sousa and the other pulmonologists in the practice have been taking turns rotating shifts covering the ICU unit at Charlton Memorial Hospital, Tobey Hospital in Wareham and occasionally at St. Lukes Hospital in New Bedford.

Sousa said they had been watching what was going on in China and then it came on in this country at an exponential rate, well before the medical field was prepared for it. Suddenly their nerves were up as they saw the rates rising and then the closings started to happen mid-March. They started to realize they didnt have good therapy for it, as it was truly a novel coronavirus that was also extremely contagious, he recalled. We all started to think were going to be at risk to our families. Potentially were going to spread it to our loved ones: wives, children. And then a lot of us thought, OK, were in the thick of it, we signed up for this but its probably a matter of if not, when we get it, but please dont let me get it now because Im needed. So we kind of had that mentality, said Sousa.

Then their colleagues nurses and doctors started getting sick and Sousa said they had to intubate a doctor who contracted it. That really hyped up your perception of this, he recalled.

Thats when his thoughts turned to staying in the "she shed in the backyard as a way of keeping his family safe during those uncertain early days of COVID-19. Sousa moved into the shed, which also doubles as a mini pool house, outfitted with a futon, cable television, a refrigerator and an electric fireplace. I would eat dinner away from them and then when it was time to go to bed I would go hit the shed. After about three weeks I got sick of it, it was getting pretty lonely so then I started sleeping in the sunroom on an air mattress and I did that for about a week and then that got old, he recalled.

After a while he started going back into the house when he was five days clear of potentially dangerous situations, like his shifts covering the ICU.

In talking to his kids about the virus, he said statistically speaking, the risk to children is small and most children who get it have symptoms that are so mild they dont even know they have it. I said, youre going to be OK. If you get it, youll be fine its just your dad has to do this. I could get sick, but Ill be alright, he said. And then I said, you know what I do for a living, I take care of sick people.

Eight of the doctors at Southcoast Health Pulmonary rotate through the ICU at Charton Memorial Hospital, meaning they do one week every eight weeks. They also do one of 16 weeks at Tobey Hospital and a smattering at St. Lukes Hospital when they need help. Additionally each partner covers the COVID-19 ward every eight weeks at Charlton. When youre in the hospital, every day is different you dont know what youre going to see, he said.

Sousa joined the practice in 2004. A native of Lisbon, he immigrated to Providence when he 7 seven years old. Even as a kid he said he knew he wanted to be a doctor and having asthma as a child made him empathetic to people with breathing problems leading to his specialty as a pulmonologist. He moved to Fall River in 2004, when he joined Southcoast Health Pulmonary. Being fluent in Portuguese has been extremely handy in caring for patients, especially in this area of the state, he said.

Dealing with COVID-19 has been by far the toughest part of his career. I never want to go through this again. Its not just the medical part, its like one eye is closed and one hand is tied behind your back. The eye closed is that early on we couldnt get the testing done and when we did it took forever to get it back. And the hand behind your back is youre running as you go. You dont have a good attack plan. It takes a lot of supportive care to get people through but weve been through this to a lesser extent before in 2008/2009 when we had H1N1, he said. And during my residency training, AIDS was a terminal illness and we were taking care of AIDS patients and even then, you put yourself at risk, but thats the job. You signed up for it.

As a support system, the doctors at Southcoast Health Pulmonary have been texting each other, bouncing ideas back and forth as the set out to treat patients with COVID-19. First they tried hydroxychloroquinine because they were desperate, though they found it out didnt work. Then they turned to convalescent plasma, which was somewhat effective and now remdesivir is the latest treatment, he said.

Adding time to patient care, they have to do whats called donning and doffing, gowning up and putting on a vented hood for each patient visit. But the toughest part, he said, is the fact that families cant be there. Its hard that youre trying to express everything by a telephone call and you just dont have that face-to-face. Its hard to tell people that your loved one isnt doing well. Only when theyre dying are they allowed to come in the hospital to spend their last moments with them, said Sousa.

The most heartbreaking, he said, is seeing loved ones FaceTiming each other before the patient is put on a ventilator. At that moment theyre looking at each other and they know, that could be the last time I see you alive. Thats hard, probably the hardest part, he added.

But at the same, he said theyve had some great moments when theyve had a patient pull through after weeks of being in the ICU. One of those patients was Somerset resident Robert Ledo, who Sousa met a couple weeks into Ledo's lengthy stay in the ICU with an extreme case of COVID-19. I did a telehealth visit with him afterward and here he is sitting at his table at home and I said, I cant believe how good you look; you look amazing. That gives you the push that this is what you want to do for a living, said Sousa.

Though cases seem to be slowing down a bit locally, Sousa said he thinks COVID-19 going to be around for a while. Being a corona class virus it rears up in the winter so it will behave in that pattern, said Sousa, adding a lot it will depend on human behavior and the risk of spreading it increases as people get complacent and let their guard down. While he understands the cause behind the recent Black Lives Matter demonstrations, for instance, Sousa said he worries about the crowds spreading the coronavirus. Its going to be with us through the winter season and it will rotate around the planet, so until we get a good therapeutic or a good vaccine, weve got to hunker down.

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You put yourself at risk, but thats the job: Fall River doctor on front line of coronavirus fight - Fall River Herald News

Researchers identify environmental components that affect gene expression in cardiovascular disease – The South End

A research team led by Francesca Luca, Ph.D., associate professor of Wayne State Universitys Center for Molecular Medicine and Genetics, has published a study that annotated environmental components that can increase or decrease disease risk through changes in gene expression in 43 genes that could exacerbate or buffer the genetic risk for cardiovascular disease. Their results highlight the importance of evaluating genetic risk in the context of gene-environment interactions to improve precision medicine.

Interpreting Coronary Artery Disease Risk Through GeneEnvironment Interactions in Gene Regulation was published in Genetics, the journal of the Genetics Society of America.

The study, said Dr. Luca, also of the WSU Department of Obstetrics and Gynecology, illustrates that combining genome-wide molecular data with large-scale population-based studies is a powerful approach to investigate how genes and the environment interact to influence risk of cardiovascular disease.

By identifying regions of DNA important for endothelial cell response to different common environmental exposures, the researchers discovered that caffeine can influence the risk of cardiovascular disease. The study demonstrates the potentially beneficial and/or detrimental effects of certain environmental exposures on the cardiovascular disease risk differ depending on individual DNA sequence.

The study focused on cardiovascular disease, Dr. Luca said, because it is the leading cause of death, both in the United States and worldwide. Also, the disease is highly multifactorial, with large contributions from both environmental and genetic risk factors. By treating endothelial cells under a controlled environment, we can discover how these genetic and environmental risk factors influence each other at the molecular level, she said. Our lab has developed expertise in cardiovascular research, with additional projects using endothelial cells to develop new assays to test the regulatory activity of genetic variants. The approach outlined in this paper can be applied to many different diseases; for example, our lab has also focused on how bacteria in the human gut affect gene expression in the colon, and also on the effect of psychosocial stress on asthma.

While the work identified regions of the genome important for how endothelial cells respond to the environment and can influence the risk of cardiovascular disease, the researchers do not yet know exactly which genetic variants are directly responsible. A former graduate student, Cynthia Kalita, developed an assay to test thousands of genetic variants for gene regulatory activity. The researchers can test the variants discovered in their study using that assay to validate and explore the mechanisms by which they exert their effects, Dr. Luca said. They also are developing computational/statistical methods that can yield better personalized risk scores.

We have extended our approach to study cardiomyocytes, which are the muscle cells of the heart. Healthy heart tissue is difficult to obtain, so we have collaborated with researchers at the University of Chicago to derive cardiomyocytes from stem cells, Dr. Luca said. This will allow us to shift our focus from the vasculature to the heart itself, where we can study diseases like cardiomyopathies and arrhythmias.

As the cost of DNA sequencing continues to decrease, Dr. Luca expects that genetic testing will play a greater role in preventive health care. To fully realize the potential of precision medicine, we need to consider both genetic and environmental risk factors of disease, and how they interact. While there are already direct-to-consumer tests that prescribe an individualized diet based on DNA, these products currently offer no demonstrated clinical value. However, with very large numbers of individuals for whom we have both DNA sequencing and information on diet and lifestyle, we may one day be able to offer better recommendations.

Others involved in the study included Anthony Findley, an M.D./Ph.D. student; Allison Richards, Ph.D., a research scientist; Cristiano Petrini, of the Center for Molecular Medicine and Genetics; Adnan Alazizi, lab manager; Elizabeth Doman, of the Center for Molecular Medicine and Genetics; Alexander Shanku, Ph.D., research scientist; Gordon Davis, of the Center for Molecular Medicine and Genetics; Nancy Hauff, Department of Obstetrics and Gynecology; Yoram Sorokin, M.D., professor of Obstetrics and Gynecology; Xiaoquan Wen, of the Department of Biostatistics at the University of Michigan; and Roger Pique-Regi, Ph.D., associate professor of the Center for Molecular Medicine and Genetics, and of the Department of Obstetrics and Gynecology.

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Researchers identify environmental components that affect gene expression in cardiovascular disease - The South End

Listen: The latest on Covid-19, vaccine politics, and diversifying genetics – STAT

Can a vaccine be an October surprise? Are journal publishers running a racket? And why is genetics so white?

We discuss all that and more this week on The Readout LOUD, STATs biotech podcast. First, we run through a busy week in news, discussing the results of a major study on Covid-19 treatment, an escalating fight in the publishing world, and the drug industrys biggest-ever IPO. Then, physician and health care policy expert Ezekiel Emanuel joins us to discuss his nightmare scenario: President Trump, desperate for re-election, forces the approval of an ineffective coronavirus vaccine. Finally, we talk to geneticist Tshaka Cunningham about the deep racial inequities in the field of genomics and what can be done to correct them.

For more on what we cover, heres the news on a potential Covid-19 treatment; heres more on the the fight over academic publishing; heres a look at inequality in genetics; and heres the latest in STATs coronavirus coverage.

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And if you have any feedback for us topics to cover, guests to invite, vocal tics to cease you can emailreadoutloud@statnews.com.

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Listen: The latest on Covid-19, vaccine politics, and diversifying genetics - STAT

A geneticist advocates for diversity and fixing his industry in the process – STAT

Over the past few weeks, 23andMe and other genetic testing companies have made headlines for releasing candid statements acknowledging that their field and their products are too white. Its a problem with which geneticist Tshaka Cunningham is all too familiar.

As executive director of the nonprofit Faith Based Genetic Research Institute, Cunningham has traveled widely to speak at Black churches about the value of genetic research. And as co-founder and chief scientific officer of a genetics startup called TruGenomix, hes working to recruit more diverse cohorts to build a genetic test for gauging risk of developing PTSD.

Cunningham recently called in to STATs podcast, The Readout LOUD, to discuss genetics and racial inequity and what needs to be done to make the field actually reflect the worlds diversity.

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The transcript of the conversation has been lightly edited for clarity.

So, Tshaka, what do you make of the reckoning that weve seen in the past couple weeks from 23andMe and other genetics companies on these issues?

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You know, I think its actually a really good thing. I was glad to see it from the highest levels from these companies acknowledging an issue that many of us in the research community have known about for quite a long time, which is this lack of representation of diverse genomes in all of our studies and products. Im glad its starting to get deeper attention because I think it is a key issue thats going to impact the effectiveness of all of these tools over time.

Im looking forward to seeing some positive things that they will do to address it. So, you know, the first step is admitting you have a problem and then you go through the steps to rehabilitate. Im hoping that some positive things will come out of this.

What kinds of questions about genetics do you hear from the communities you speak with?

All kinds of questions. And first of all, I say, you know, the work that were doing with the Faith Based Genetic Research Institute is very unique in that we are bringing together individuals from the faith communities with scientists who are also people of color, and one of our guiding principles in the work that we do in the community is called the honest broker philosophy. That is, those of us who are imparting the information to the community are also from the community. And what we found is that it really helps us establish a better bond of trust for folks to be able to receive the information.

Some of the questions that we get when we talk about the value and the benefits of genetic research is the first questions are, you know, are they going to use it to hurt me? Thats the first question we get a lot from African American participants. And, you know, what will they do with the information? Theres a fair bit of distrust out there. And some of it is quite warranted from past transgressions of the medical establishment on the African American community. But once you sort of talk through those issues with folks and really kind of allow them to see some of the potential benefits, then you start getting a high level of interest.

So lets say 23andMe, for example, or one of the large companies, were to call you and ask for advice on what to do to make their products less Eurocentric and more inclusive. What would you tell them?

Start by making sure that your team, your executive team specifically, is representative of the community. A lot of companies sort of say, well, we cant find them. Any company needing to find a talented minority geneticist give me a call. Ive got a long list.

The second step would be to really use some of your resources to sponsor more research in this area. I mean, part of the challenge is also a financial and economic challenge. When you think about the economic disparities that have existed in America based on racial lines you know, the average African American has seven times less wealth than the average Caucasian. So they might not have even a hundred bucks to spend on something like genetic testing that could benefit them.

And then theres also the messaging. I think to the extent that these companies could help organizations like ours, the Faith Based Genetic Research Institute, other academic institutions, with messaging about the importance or the potential benefits of this, that would be great.

Now, I know thats a fine line that they have to walk because, you know, you dont want to seem coercive. But at the same time, I think trying to really do authentic outreach to the community would start with having more of your employees be from the community and then having a dedicated effort of that kind of outreach within your operation.

One of the more controversial questions in this conversation is around compensation. So what do you think? Do you think that 23andMe should pay people in the Black community and other underrepresented populations for their data?

I believe anybody that contributes their data should have the opportunity to get paid for it if its used. I do not believe in coercing someone to contribute their data with payment. But if Im an individual who has contributed and then you go and use my my data lets say a pharma company buys access to my data and I dont see any benefit from it, then that feels a bit un-American and I just dont feel like its fair. But thats my personal opinion.

So lets talk a little bit about polygenic risk score tests, which really encapsulate the diversity problems in genetics. So, for readers who are unfamiliar with them, these are tests that gather multiple genetic variants together and use them to predict someones chances of developing a disease. So far, many commercial polygenic risk score tests have come off warnings that theyre not very accurate or are even useless in people who are not of European ancestry. But your startup, TruGenomix, is working on a polygenic risk score test to try to gauge risk for developing PTSD. And youre trying to build the test using more diverse data. Tell us about your approach.

Ive recognized the importance of diversity in your datasets. From my earliest days, when I was at the Department of Veterans Affairs, we had a large genomics project called the Million Veteran Program. And part of my contribution to that project was to make sure that minority veterans participated. And so we actually went to great effort to ensure that. And that project has done very well to the credit of the VA, to recruit minority veterans. So that data set is going to provide some rich understanding, or has that potential to provide rich understanding, in polygenic risk for minority communities.

I took some of what I learned there from having to really take the time to do the outreach to the communities, to make sure that the end products are representative. I think that is just core to our actual DNA as a company. I think part of that has to do with the fact that were one of the very few minority-owned genomics companies in the country right now. This was top of mind for us. We wanted to make sure that whatever products we were putting out, the polygenic risk related to all communities, specifically the African American community, which my founders and I come from. It was just a very important thing for us to do not only for societal and ethical reasons, but also for scientific integrity reasons, because as a scientist, I dont believe in putting out products that arent probably applicable to all communities.

So why havent other makers of polygenic risk score tests taken this more holistic approach?

You know, I cant speak for them. I mean, I dont know. Thats a question that I have. I would hope that they take a deeper look at it. Maybe their market calculations were, OK, the people using genetic tests now tend not to be people of color. And therefore, we dont need to care about them. I dont know. Youll have to ask them that question.

All I could say is that I hope that all of the companies that are making these kinds of tests really take diversity seriously. Ive given lectures around diversity and genetics in the past. The majority of the DNA in the world is not of Caucasian origin. Its actually of Asian origin. And then African and Latino. And then Caucasians are only maybe about 14% of all the DNA out there just based on population. So when you think about it in that respect, if you really want to have a genome that is globally applicable, then youd really need to focus on its diversity.

Tshaka, thank you for coming on the podcast today.

Great. Its great being with you all today.

Theresa Gaffney contributed to this report.

This is a lightly edited transcript from arecent episodeof STATs biotech podcast, The Readout LOUD. Like it?Consider subscribing to hear every episode.

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A geneticist advocates for diversity and fixing his industry in the process - STAT