All posts by medical

Biochemistry

Rising Demand for Clinical Biochemistry Analyzer Market to Significantly Boost Revenues through the COVID-19 Crisis – Cole of Duty

A fresh specialized intelligence report published by KandJ Market Research with the title Global Clinical Biochemistry Analyzer Market Research Report By Type, Application and Regions Forecast to 2026 has the ability to help the decision-makers in the most important market in the world that has played a significantly important role in making a progressive impact on the global economy. The Global Clinical Biochemistry Analyzer Market Report present and showcase a vital vision of the global scenario in terms of market size, market potentials, and competitive environment. The study is derivative from primary and secondary statistical data and consists of qualitative and quantitative analysis of the industry and key players.

The latest report includes the Impact of Coronavirus on the Clinical Biochemistry Analyzer Industry, which includes on Industry Upstream, Industry Downstream, Industry Channels, Industry Competition, and finally on Industry Employment.

The Final Report Will Include the Impact of COVID 19 Analysis in This Clinical Biochemistry Analyzer Industry. For Sample Report & Graphs & Charts @: https://www.kandjmarketresearch.com/sample-request/340727

The global Clinical Biochemistry Analyzer market is showing promising signs that can be explored well in the coming days to achieve a notable valuation by the end of 2026. The process would also witness a growth by % CAGR in between 2021 and 2026. The report is expected to consider the time-frame as the forecast period and it would deal with the market accordingly. Growth-inducing factors have been monitored closely in the report to gauge well the progress of the market. Each factor can play a significant role and has been given proper space on the basis of which the market can devise strategies. It has tracked various associated fields as well to get a proper map of how these end user industries are impacting the market and can take the market forward. The report has credibility as it banks on the expertise of adept researchers who fetch numbers from a pool of information and sieve them as per the requirement. In the process, they have gone through the market by having it analysed on top-down and bottom-up basis.

Key Segments Studied in the Global Clinical Biochemistry Analyzer Market:-

Leading players of Clinical Biochemistry Analyzer including:

Ask for Discount @https://www.kandjmarketresearch.com/discount/340727

Market split by Type, can be divided into:-

Market split by Application, can be divided into:-

Market segment by Region/Country including:-

The Final Report Will Include the Impact of COVID 19 Analysis in This Clinical Biochemistry Analyzer Industry.

Buy 1-user PDF @ https://www.kandjmarketresearch.com/buyreport/cart?report_id=340727

The segmentation plays a prominent role in dealing with the growth of the Clinical Biochemistry Analyzer market where various types and applications are promoting better understanding of the market. This segmentation has a strong foundation in volume-wise and value-wise data which backs the process of understanding the market scenario with numbers. The market has been combed through properly to get all the factors in line. The report has been enriched interviews as a first hand method of getting data. These interviews include chats with top market players, market analysts, distributors, people in the field of research and development and others owing to which the reliability of the report has increased significantly.

Regional market analysis of the report has backed the study of different regions as an attempt to understand growth pockets that can be beneficial for the market. The regional analysis has import, export, and other processes covered. Players who are getting involved in the market for a better growth are looking for these growth pockets to capitalize on the opportunities provided and find new scopes for growth. Certain countries have been tracked in detail to monitor them closely as they can be major markets in the coming years. Benefits like better infrastructure, cost-effective labor, access to raw materials, they offer have become luring factors for many market players and they want to expand their business to these regions to increase their profit margin.

Read More Detailed Information regarding Clinical Biochemistry Analyzer Industry with Covid-19 Updates @ https://www.kandjmarketresearch.com/reports/340727-global-clinical-biochemistry-analyzer-market-research-report-by-type-application-and-regions-forecast-to-2026

About Us:-

Kandjmarketresearch.com is part of the KnowledgeNJournals Research Firm which provides premium progressive market research reports, statistical surveying, analysis & forecast data for industries and governments from hundreds of publishers around the world. We have almost all top publishers reports in our collection to provide you with instant online access to the worlds most complete and fresh database on a Daily Basis. We are at KandJ Market Research are inspired to help our clients grow by providing appropriate business insight with our huge market intelligence source.

If you have any special requirements for the report, please let us know and we will offer you a customized report on separate regional or country-level reports.

Contact us:-

KandJ Market Research

(Part of KnowledgeNJournals Research)

E-mail: [emailprotected]

Website: https://www.kandjmarketresearch.com

(USA): +1 661 636 6162 | (IND): +91 932 580 2062

View post:
Rising Demand for Clinical Biochemistry Analyzer Market to Significantly Boost Revenues through the COVID-19 Crisis - Cole of Duty

Biochemistry

Gene yields insights into the causes of neurodegeneration | Cornell Chronicle – Cornell Chronicle

Across the globe, approximately 50 million people are living with dementia. The two most common forms are Alzheimers disease and frontotemporal lobar degeneration (FTLD), which develop when neurons in specific parts of the brain stop functioning triggering memory loss and other behavioral or personality changes.

Without a cure, the World Health Organization predicts that number could rise by as many as 10 million cases per year. However, predicting the onset of these diseases is tricky because neurodegeneration can start years before people present any outward symptoms.

An electron microscope shows the myelin sheath in a healthy mouse brain. The myelins fatty tissue insulates neurons and protects them from damage.

Cornell researchers including Fenghua Hu, associate professor in the Department of Molecular Biology and Genetics and member of the Weill Institute for Cell and Molecular Biology, are taking a closer look at the factors that cause Alzheimers, FTLD and similar diseases. Hus latest study, A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination, was published June 23 in the journal Brain.

I want to have a better understanding of the molecular and cellular mechanisms of neurodegeneration, Hu said. I hope that our research can facilitate therapeutic development of treatment options for patients suffering from neurodegenerative diseases and other brain disorders.

Her team started by investigating a specific gene, called TMEM106B, which had been previously identified as a risk factor for several neurodegenerative diseases, including Alzheimers and FTLD. Researchers also knew that a particular mutation in that gene caused a neurological defect known as hypomyelinating leukodystrophy, which creates a myelin deficit in the brain, leading to the deterioration of both motor skills and mental acuity.

Myelin is the fatty tissue that wraps around nerve fibers, or axons, in the nervous system. Like insulation, this tissue forms a sheath that surrounds the nerve fibers, protecting them from damage and allowing electrical impulses to be quickly transmitted along the nerve.

Hu wanted to see exactly how that one mutation in TMEM106B could cause so much damage. She also wanted to learn more about how the gene regulates the formation and maintenance of the myelin sheath under normal conditions.

We found that the mutation associated with the disease is a loss-of-function mutation, Hu said.

This distinction is critical since the Hu lab saw that TMEM106B is expressed in the cells that are responsible for forming the protective myelin tissue. Those cells are called oligodendrocytes, and within them, TMEM106B resides in the lysosome a tiny organelle that acts as a cellular recycling center.

Like the stomach, the lysosome must maintain a specific pH to keep its enzymes active. As oligodendrocytes build the myelin sheath, lysosomes remove any extraneous materials. They can also store myelins main membrane protein and deposit it in areas surrounding the nerve fibers.

Hus team discovered that the TMEM106B mutation prevented the gene from regulating both the pH inside the lysosome and the movement of the lysosome itself inhibiting the oligodendrocytes ability to build compact myelin layers.

Using a mouse model, Hu also noticed that an overall TMEM106B deficiency led to abnormal lysosome movement within the oligodendrocytes. This created defects in the myelin sheath, and the team observed behavioral changes, including poor motor coordination.

Additional research will examine the exact mechanism by which TMEM106B regulates lysosome function and will demonstrate how the mutation leads to the known neurological defects.

We want to explore whether the genes regulation of myelination contributes to its association with neurodegenerative diseases, including Alzheimers, FTLD and other age-related dementia, Hu said.

First author on the paper is postdoctoral associate Tuancheng Feng, and co-authors include other members of the Hu lab: Rory Sheng 19, Mohammed Ullah 21, Christina Mendoza 19, Isabel Iscol Katz 21, Daniel Paushter, Ph.D. 18, Peter Sullivan, Ph.D. 17, lab technician Xiaochun Wu, and former students Xiaolai Zhou and Laura Camila Martinez Enriquez.

Collaborators also include Fred Maxfield, professor in the Department of Biochemistry at Weill Cornell Medicine, and his research associate Santiago Domenech.

Hu received funding from the Bluefield project to cure frontotemporal dementia, National Institute on Aging, and National Institute of Neurological Disorders and Stroke.

Jana Wiegand is the editorial content manager for the College of Agriculture and Life Sciences.

Continued here:
Gene yields insights into the causes of neurodegeneration | Cornell Chronicle - Cornell Chronicle

Biochemistry

Letter to the Editor: Wu should speak up about Roxbury Prep – Dorchester Reporter

To the Editor:In February, I had a private meeting with City Councillor Michelle Wu in her office along with my former principal and current staff member at Roxbury Prep High School. We were there to ask that my school, Roxbury Prep, be treated fairly. For 400 days, my school has waited to be placed on the Boston Planning & Development Agency (BPDA) agenda for a vote on a project for a new high school at 361 Belgrade Ave. in Roslindale, a site that is already zoned for a school.

For the past several years, my peers in 11thand 12thgrade have been separated from 9thand 10thgraders. We didnt have a cafeteria or updated science labs. We ate lunch at our desks and walked a mile to theYfor gym. Meanwhile, 361 Belgrade continues to stand as an unused automotive service center instead of a beautiful public high school for beautiful Black and Latinx children.

I am grateful that many elected officials of color have already taken a position of support for our cause. I wanted Councillor Wu to do so as well. She lives in Roslindale, where our proposed school would be. We appealed to her for help. I was surprised by what she told me in that meeting in February.

She told us: You have been mistreated. You have been made to go on a wild goose chase. The reason you have not been placed on the agenda stems from racism. And then she told us that she would remain silent on this injustice.

She doesnt want to see a school at that site, even though it is zoned for a school. This is fine. Everyone is entitled to theiropinion. What is disheartening is that the councillor declined to call out the injustice in her own community, in her own back yard.

I just graduated from high school. Im headed to Brown University on a full scholarship to study biochemistry, despite the fact that our inadequate school building didnt have the type of lab that my new peers at Brown would have had. But my siblings are in middle school at Roxbury Prep. They deserve the new high school that my peers and I deserved and didnt get.

The world is different today than it was in February. Many people are recognizing that silence from good people is a tool of oppressors, allowing people to easily ignore the problem at hand. Councillor Wu wrote in her email to supporters recently: Black Lives Matter. And we must all use every platform and lever of power to confront racism in our lives, laws, and institutions.

She added: To move forward, the question for every elected official should not be whether we can point to some work to address racism, but whether we are taking all possible action within our power to implement anti-racist policies, from legislation to budgets and oversight. Hold us accountable to get it done.

I am hopeful in reading those words. Perhaps Councillor Wu now recognizes what that means to the students and families of Roxbury Prep and that she will finally make a public statement about 361 Belgrade.

YinessaBaezRoxbury Prep Class of 2020

More here:
Letter to the Editor: Wu should speak up about Roxbury Prep - Dorchester Reporter

Biochemistry

New ICE rule leads to concerns about the future of Utahs international students – ABC 4

SALT LAKE CITY, Utah (ABC4 News) As the country continues to grapple with the COVID-19 pandemic, many college and university students are opting to take a full load of online classes next month. But for international students, that could mean disqualification to remain in the United States legally.

We are not sure what the rationale behind this is. But what I think as an immigration attorney is that President Trump is creating an invisible wall to keep our foreign nationals from coming or staying in the United States, said Kim Buhler-Thomas. I believe why were doing this is more of a political move so he can have a stronger backing from his constituents.

Laura Fonseca, a business major at Salt Lake Community College flew to her native country, Colombia to visit family for spring break. But due to the seriousness of the COVID-19 pandemic and travel restrictions, she hasnt been able to return to Utah.

The airports were closed and theyre still closed, she said.

Meanwhile, BYU biochemistry student Peter Liang has remained at home while taking online classes to keep his wife and baby safe.

The fear of getting COVID-19 and bringing it back to my family really weighs heavily on me on a mental level. My wife has some health concerns and if she got the virus, she could have very serious symptoms, he said.

On Monday, Immigration and Customs Enforcement (ICE) announced a new rule that requiresinternational students on an F-1 or M-1 visa to take no more than one class online at a college or university unless the course has an in-person component. Those who fail to comply could be forced to return to their native country.

The announcement left thousands of international students in Utah concerned about their health and safety during the pandemic.

I was shocked by this policy change because Ive always felt like the U.S. has been a country where humanity is one of its principal values. This policy is just so brutal towards international students. It feels like we have to choose between COVID-19 or leaving the U.S. I think its inhumane, said Liang.

Im really worried about the possibility that when school opens in the fall, were going to see a rise in cases which will force classes to move completely online again. If that happens in the middle of the semester, I would have to move back to Korea, said Jee Ha, a mechanical engineering student at the University of Utah.

The policy further complicated Mary Jantalerts situation, who explains that she already completed her Masters degree and was planning to leave the country to pursue her career before the COVID-19 pandemic hit and led to travel restrictions.

I reached out to Homeland Security and they said they were not extending their grace period so they told me to go back to school if I wanted to stay here legally, she said.

Jantalert enrolled for a software development program in the meantime at Salt Lake Community College to maintain her student status. But ICEs new rule, she says, puts her in limbo because her native country of Thailand currently has travel restrictions that would prevent her from re-entering their borders.

I feel so confused. I dont know what the benefit of this is for either side. We international students pay triple the amount of tuition that a resident student pays. So they would lose all that money if a bunch of us left, she said.

ButBuhler-Thomas said there is some hope. Harvard University and the Massachusetts Institute of Technology filed a lawsuit Wednesday against the new rule.

If successful, it would institute a temporary restraining order and prevent the government from enforcing the directive. Therefore, buying time for international students who would have otherwise only have six weeks to take action.

They just have to show irreparable harm to their institution if this order is allowed to continue, she said. We would hope that this injunction would apply across the board for all schools.

Other potential barriers posed to international students may include lack of financial means to return to their native country, difficulty of transferring to another institution, lost opportunity to work in the U.S. after graduation, and emotional trauma.

I dont know how long it will be until I can return to the United States and what if I dont make it back before Fall semester to fulfill that in-person requirement? Im so stressed out and Im so sad because Im close to graduating, said Fonseca.

Buhler-Thomas said there are still many questions that remain about the new rule. Consequently, international students may have to transfer to another institution, request a visa from a third country, or risk deportation while staying in the U.S.

ABC4 News reached out to six of Utahs universities and two colleges to ask about online v. in-person class availability. Most will offer a mixture of both in the fall, but some have not made their decisions yet.

Time is not on our side because we only have a few weeks before we find out what our options are. Thats not a lot of time for someone if they have to pack up their life and move out of the country, said Jantalert.

Officials from all eight schools that ABC4 News contacted ensured they would work with international students to make sure they could lawfully remain in the United States. For more information about a specific institution, please refer to statements provided below.

Read the rest here:
New ICE rule leads to concerns about the future of Utahs international students - ABC 4

Physiology

NIH researchers reframe dog-to-human aging comparisons – National Institutes of Health

News Release

Thursday, July 9, 2020

Comparing epigenetic differences between humans and domestic dogs provides an emerging model of aging.

One of the most common misconceptions is that one human year equals seven dog years in terms of aging. However, this equivalency is misleading and has been consistently dismissed by veterinarians. A recent study, published in the journalCell Systems, lays out a new framework for comparing dog-to-human aging. In one such comparison, the researchers found the first eight weeks of a dogs life is comparable to the first nine months of human infancy, but the ratio changes over time. The research used epigenetics, a process by which modifications occur in the genome, as a biological marker to study the aging process. By comparing when and what epigenetic changes mark certain developmental periods in humans and dogs, researchers hope to gain specific insight into human aging as well.

Researchers performed a comprehensive analysis and quantitatively compared the progression of aging between two mammals, dogs and humans. Scientists at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, and collaborators at the University of California (UC) San Diego, UC Davis and the University of Pittsburgh School of Medicine carried out the research.

All mammals experience the same overarching developmental timeline: birth, infancy, youth, puberty, adulthood and death. But researchers have long sought specific biological events that govern when such life stages take place. One means to study such a progression involves epigenetics gene expression changes caused by factors other than the DNA sequence itself. Recent findings have shown that epigenetic changes are linked to specific stages of aging and that these are shared among species.

Researchers focused on one type of epigenetic change called methylation, a process in which molecules called methyl groups are attached to particular DNA sequences, usually parts of a gene. Attaching to these DNA regions effectively turns the gene into the "off" position. So far, researchers have identified that in humans, methylation patterns change predictably over time. These patterns have allowed the creation of mathematical models that can accurately gauge the age of an individual called "epigenetic clocks."

But these epigenetic clocks have only been successful in predicting human age. They do not seem to be valid across species, such as in mice, dogs, and wolves. To see why the epigenetic clocks in these other species differed from the human version, researchers first studied the epigenetic changes over the lifetime of a domestic dog and compared the resultsobtained with humans.

Dogs are a useful model for such comparisons because much of their environment, diet, chemical exposure, and physiological and developmental patterns are similar to humans.

"Dogs experience the same biological hallmarks of aging as humans, but do so in a compressed period, around 10 to 15 years on average, versus over 70 years in humans. This makes dogs invaluable for studying the genetics of aging across mammals, including humans," said Elaine Ostrander, Ph.D., NIH Distinguished Investigator and co-author of the paper.

Dr. Ostrander and her colleagues in Trey Ideker's laboratory at UC San Diego took blood samples from 104 dogs, mostly Labrador retrievers, ranging from four weeks to 16 years of age. They also obtained previously published methylation patterns from 320 people, whose ages ranged from 1 to 103 years. The researchers then studied and compared the methylation patterns from both species.

Based on the data, researchers identified similar age-related methylation patterns, specifically when pairing young dogs with young humans or older dogs with older humans. They did not observe this relationship when comparing young dogs to older humans and vice versa.

The study also found that groups of specific genes involved in development can explain much of the similarity, which had similar methylation patterns during aging in dogs and humans.

"These results suggest that aging can, in part, be explained by a continuum of changes beginning in development," said Dr. Ideker. "The programs of development are expressed incredibly strongly at defined periods when the pup is in the womb and childhood. But equally strongly are systems that clamp down to stop it. In a sense, we are looking at aging as the residual 'afterburn' of those powerful forces."

The researchers also attempted to correlate the human epigenetic clock with dogs, using this as a proxy for converting dog years to human years.

The new formula is more complicated than the "multiply by seven" method. When dogs and humans experience similar physiological milestones, such as infancy, adolescence and aging, the new formula provided reasonable estimates of equivalent ages. For example, by using the new formula, eight weeks in dogs roughly translates to nine months in humans, which corresponds to the infant stage in both puppies and babies. The expected lifespan of senior Labrador retrievers, 12 years, correctly translates to 70 years in humans, the worldwide average life expectancy.

The group acknowledges that the dog-to-human years formula is largely based on data from Labrador retrievers alone. Hence, future studies with other dog breeds will be required to test the formula's generalizability. Because dog breeds have different life spans, the formula may be different among breeds.

Dr. Ostrander noted, "It will be particularly interesting to study long-lived breeds, a disproportionate number of which are small in size, versus breeds with a shorter lifespan, which includes many larger breeds. This will help us correlate the well-recognized relationship between skeletal size and lifespan in dogs."

The study also demonstrates that studying methylation patterns may be a useful method to quantitatively translate the age-related physiology experienced by one organism (e.g., humans) to the age at which physiology in a second organism is most similar (e.g., dogs). The group hopes that such translation may provide a useful tool for understanding aging and identifying ways to maximize healthy lifespans.

"This study, which highlights the relevance of canine aging studies, further expands the utility of the dog as a genetic system for studies that inform human health and biology," said Dr. Ostrander.

This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research.

NHGRI is one of the 27 institutes and centers at the National Institutes of Health. The NHGRI Extramural Research Program supports grants for research, and training and career development at sites nationwide. Additional information about NHGRI can be found at https://www.genome.gov.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

###

See the rest here:
NIH researchers reframe dog-to-human aging comparisons - National Institutes of Health

Physiology

Lung physiology and immune function could spare children from severe COVID-19 – News-Medical.Net

Reviewed by Emily Henderson, B.Sc.Jul 8 2020

Differences in lung physiology and immune function in children could be why they are more often spared from severe illness associated with COVID-19 than adults, according to pediatric and adult physicians at The University of Texas Health Science Center at Houston (UTHealth) and Baylor College of Medicine, who teamed up to investigate the disparity.

The perspectives paper was recently published in American Journal of Physiology-Lung Cellular and Molecular Physiology.

According to the paper, only about 1.7% of the first 149,082 cases in the U.S. were infants, children, and adolescents younger than 18 years old. Authors noted that children under 18 make up 22% of the U.S. population. Only three pediatric deaths were identified by the Centers for Disease Control and Prevention (CDC) as of April 2020.

"These profoundly decreased rates of symptomatic infection, hospitalization, and death are well beyond statistical significance, require further examination, and may hold the key to identifying therapeutic agents," the authors wrote.

Angiotensin-converting enzyme 2s, called ACE2, are the doors that allow SARS-CoV-2, the novel coronavirus that causes COVID-19, to enter the body's cells. Children naturally have less ACE2 in the lungs than adults.

ACE2 are important for viral entry and there seems to be less of them in children, because they increase with age."

Matthew Harting, MD, MS, assistant professor in the Department of Pediatric Surgery at McGovern Medical School at UTHealth, pediatric surgeon with UT Physicians, and senior author of the paper

Harting is also director of the pediatric ECMO program providing advanced cardiac and respiratory support at Children's Memorial Hermann Hospital.

In addition to fewer ACE2 receptors, the authors note the immune system in children responds to viruses differently than that of adults, leaving less opportunity for severe illness in pediatric patients. There are several different mechanisms behind the differences, including the retention of T-cells in children, which are able to fight off or limit inflammation.

"T-cells have a viral response and also an immune modulator response. In severe cases of adult COVID-19 patients, we've seen that those T-cells are reduced, so the ability to fight the virus is also reduced. In kids, those T-cells seem to be maintained, so they are still able to prevent the virus," said Harry Karmouty-Quintana, PhD, an assistant professor in the Department of Biochemistry and Molecular Biology at McGovern Medical School, and a co-author of the paper.

Lung tissue in children naturally has a higher concentration of regulator T-cells. Patients with higher levels of T-cells also have higher levels of Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor, an anti-inflammatory cytokine.

"IL-10 inhibits the inflammation of other components like IL-6 that are detrimental. Adults tend to experience hyperinflammatory state, where kids do not," Karmouty-Quintana said. "In preclinical studies in mice, IL-10 has also shown to decrease with age."

The paper's findings were made possible through collaboration in a multidisciplinary group made up of pediatric and adult physicians and scientists in pediatric surgery, adult critical care, neonatology, and molecular biology.

"We, as physicians, have been challenged with the question of how to treat COVID-19 and we're learning in real time," said Bindu Akkanti, MD, associate professor of critical care medicine with McGovern Medical School, attending physician in critical care with Memorial Hermann-Texas Medical Center, and a study co-author. "I knew that to figure out the best way to treat adults, we needed to get a team together to get to the bottom of why children were being spared from severe illness related to the virus. So, I reached out to Dr. Karmouty-Quintana and we teamed up with Dr. Harting and two other physicians in the Texas Medical Center to start investigating." Akkanti also sees pulmonary patients at UT Physicians.

"Collaborations like this between adult and pediatric providers are really important and this disease highlights where we can learn a lot when we compare the way it behaves in younger kids with older people," Harting said. "Even now as we're learning about effective treatments, we're seeing younger people handle this disease better than older people. Moving forward, physicians and scientists need multidisciplinary collaboration to continue learning - this is just another step in the right direction to attack this virus."

Krithika Lingappan, MBBS, was the first author of the paper and Jonathan Davies, MD, was a co-author. Both Lingappan and Davies are assistant professors of pediatrics at Baylor College of Medicine and neonatologists with Texas Children's Hospital.

As a result of the collaboration, the team has begun a new study using blood samples from patients in different stages of COVID-19 to continue to understand how to treat the virus and the disparities in disease progression between children and adults.

Source:

Journal reference:

Lingappan, K., et al. (2020) Understanding the age divide in COVID-19: why are children overwhelmingly spared?. American Journal of Physiology - Lung Cellular and Molecular Physiology. doi.org/10.1152/ajplung.00183.2020.

View post:
Lung physiology and immune function could spare children from severe COVID-19 - News-Medical.Net

Physiology

Sensors were allowed to prove themselves by test with increased pre-night temperature in tomato – hortidaily.com

In 'The Road to Digital Green Fingers' project, researchers increased the pre-night temperature in a tomato cultivation by one degree for four weeks. In this way, the crop was 'bullied' to see how far it could go, but especially also to understand the physiology behind the measurements. The better that goes, the easier it will be to cultivate remotely later on.

"The crop is now recovering," said Alex van Klink of the Delphy Improvement Center, responsible for the research for the project, about the treatment that was stopped in week 24. He saw that the crop started to consume assimilates faster. "In itself we can explain from the physiology what the raising of the pre-night temperature does, but the question for us is mainly whether you can also catch it with sensors and then also can understand it."

Alex in the test greenhouse

Understanding measurementsIn the latter, the researchers from Delphy and Wageningen University & Research are interested in and various other parties as well, namely AgroEnergy, 2Grow, De Ruiter Seeds, Hazera Seeds, Signify and Ludvig Svensson. All parties are primarily concerned in understanding plant reactions with the sensor network. In this way, plant responses can be measured before they are visible to the naked eye. Ultimately, this should lead to the application of the knowledge in order to start controlling the cultivation.

More objective measuringUsing a combination of, among other things, sap flow sensors and scales to measure the weight of the plant, the researchers are mapping balance or imbalance in water consumption, assimilates, but also in growth height and fruits.

"By using sensors for more objective measuring in the near future, you can see things that the grower or advisor cannot see with the naked eye. That means that the grower can soon be less in the greenhouse and also that you can limit the movements of advisers from greenhouse to greenhouse. An advantage with the high virus pressure that is present in, for example, tomatoes."

Six treatments testedIn total, six treatments will be tested in the project, which runs until mid-September and for which financial support was obtained from the Topsector Tuinbouw & Uitgangsmaterialen. "With EC, lighting and irrigation, well also be looking for the limit again. And in case we would cross it, that will also be instructive. We have that advantage over production growers."

A follow-up test can then be carried out with the acquired knowledge. In this way, greenhouse horticulture is progressing step by step towards autonomous cultivation, but not without people that will be able to keep in step with the technology and also will be able to fully rely on it. The latter is an important condition for the grower with green fingers in order to relinquish control.

For more information:Delphywww.delphy.nl

Alex van Klinka.vanklink@delphy.nl

More:
Sensors were allowed to prove themselves by test with increased pre-night temperature in tomato - hortidaily.com

Physiology

Trial to see if immune booster can protect cancer patients from Covid-19 – ThePrint

Text Size:A- A+

New Delhi: As the coronavirus pandemic continues to rage through the world, scientists are making new revelations about the virus every day.

Here are some of the latest research developments on the Covid-19 front.

Scientists in Canada have launched clinical trials focussed on strengthening the immune system for cancer patients one of the most vulnerable populations to protect them from Covid-19.

The trial involves IMM-101, an inactivated bacteria that broadly stimulates the innateimmune system, which is the first to kick in when the body encounters a novel pathogen.

The researchers hope that boosting cancer patients immune systems with IMM-101 will protect them from developing severe Covid-19 and other dangerous lung infections.

The researchers said that an effective vaccine providing specific protection against Covid-19 could take another year or more to develop. Meanwhile, they believe the IMM-101 may be able to protect cancer patients from developing a serious Covid infection.

Also read: Asthma does not increase risk or severity of Covid-19, says new study

We are deeply grateful to our readers & viewers for their time, trust and subscriptions.

Quality journalism is expensive and needs readers to pay for it. Your support will define our work and ThePrints future.

SUBSCRIBE NOW

A review of Covid-19 patients has shown that cases of brain complications linked to the coronavirus infection, such as confusion, stroke and inflammation of the brain, are occurring across the globe.

Published in The Lancet Neurology, the study has found that strokes, delirium and other neurological complications have been reported from most countries with large outbreaks of the disease.

The infection caused by the novel coronavirus has been mostly associated with problems such as difficulty in breathing, fever and cough. However, it is now becoming clear that other problems can also occur in patients.

For this study, researchers analysed findings from Covid-19 studies across the globe that reported on neurological complications. The review included studies from China, Italy and the US. It found nearly 1,000 patients with Covid-19-associated brain, spinal cord and nerve diseases.

While these complications are uncommon, the large number of Covid-19 cases globally means the overall number of patients with neurological problems is also likely to be high.

Naturally occurring molecules called resolvins can be harnessed to control the life-threatening immune reaction, called a cytokine storm, in Covid-19 patients, scientists have said.

A cytokine storm is when the bodys immune system overreacts and begins attacking healthy cells too.

The cytokine storm in Covid-19 patients can lead to respiratory failure, organ damage and potential death.

In a study published in the Cancer and Metastasis Reviews, researchers have said that controlling the local and systemic inflammatory response in Covid-19 may be as important as anti-viral therapies.

They suggest that a family of molecules naturally produced by the human body may be harnessed to resolve inflammation in patients with severe Covid-19. This would reduce the acute respiratory distress and other life-threatening complications associated with the viral infection.

Resolvins can actively turn off inflammation. Researchers have previously demonstrated that resolvins and related molecules can play a role in preventing cancer metastasis and progression.

These are current clinical trials on these molecules, to look at their use against other inflammatory diseases. Scientists have suggested that they could be re-deployed for the management of Covid-19.

Scientists have identified the differences in lung physiology and immune function in children that could explain why they are less susceptible to severe Covid-19 illness than adults.

Published in the American Journal of Physiology-Lung Cellular and Molecular Physiology, the study suggests that children naturally have less ACE2 in the lungs than adults. Angiotensin-converting enzyme 2s, called ACE2, allow SARS-CoV-2 to enter the bodys cells.

According to the study, only about 1.7 per cent of the first 1,49,082 cases in the US were under 18 years of age.

The findings from the study require further examination, and may hold the key to identifying therapeutic agents, researchers have said.

Months of self-isolation and social distancing can trigger stressors in the body that increase vulnerability to upper respiratory viruses and perhaps coronavirus, a study has suggested.

To slow the spread of coronavirus, many communities issued stay-at-home measures, increasing interpersonal stressors like loneliness, loss of employment and familial conflict.

According to an article published in the Perspectives on Psychological Science, these stressors may be powerful predictors of how a person will respond if exposed to coronavirus.

In a series of studies, researchers found that participants experiencing interpersonal stressors had a greater chance of developing upper respiratory illnesses when exposed to cold viruses.

Interpersonal stressors might play a similar role in response to the coronavirus, increasing a persons vulnerability to Covid-19.

The study indicates that social support may offer a protective shield against respiratory infection and illness.

Also read: CanSino, Moderna, Novavax: A list of Covid vaccines under clinical trials across the world

Subscribe to our channels on YouTube & Telegram

News media is in a crisis & only you can fix it

You are reading this because you value good, intelligent and objective journalism. We thank you for your time and your trust.

You also know that the news media is facing an unprecedented crisis. It is likely that you are also hearing of the brutal layoffs and pay-cuts hitting the industry. There are many reasons why the medias economics is broken. But a big one is that good people are not yet paying enough for good journalism.

We have a newsroom filled with talented young reporters. We also have the countrys most robust editing and fact-checking team, finest news photographers and video professionals. We are building Indias most ambitious and energetic news platform. And we arent even three yet.

At ThePrint, we invest in quality journalists. We pay them fairly and on time even in this difficult period. As you may have noticed, we do not flinch from spending whatever it takes to make sure our reporters reach where the story is. Our stellar coronavirus coverage is a good example. You can check some of it here.

This comes with a sizable cost. For us to continue bringing quality journalism, we need readers like you to pay for it. Because the advertising market is broken too.

If you think we deserve your support, do join us in this endeavour to strengthen fair, free, courageous, and questioning journalism, please click on the link below. Your support will define our journalism, and ThePrints future. It will take just a few seconds of your time.

Support Our Journalism

Visit link:
Trial to see if immune booster can protect cancer patients from Covid-19 - ThePrint

Physiology

Jeremy Xu Joins Ingredion as Senior Vice President and Chief Innovation Officer – GlobeNewswire

WESTCHESTER, Ill., July 09, 2020 (GLOBE NEWSWIRE) -- Ingredion Incorporated (NYSE: INGR), a leading global provider of ingredient solutions, today announced that Jeremy Xu has been named senior vice president, and chief innovation officer, effective October 1. In this capacity, Xu will be responsible for advancing the Companys focus on specialty growth platforms, identifying new growth opportunities and overseeing the Ingredion Idea Labs innovation centers. Xu will report to Jim Zallie, president and chief executive officer.Xuwill succeed Tony DeLio who will be retiring in February 2021 after 14 years of service.

Xu joins the Company from Royal DSM, where he spent four years leading a global business unit in the nutritional ingredients space. Before that role, he spent 16 years at DuPont serving in a variety of leadership roles across Asia and the U.S.

Jeremy is an accomplished global leader with a strong reputation for successfully driving innovation and growth while cultivating high-performing, agile teams, said Zallie. Jeremy brings a global perspective and deep specialty food ingredient experience, which is critical as we identify new opportunities for our customers. We look forward to having an executive of his caliber join the Ingredion team.

Xu holds a bachelors degree in biology and biomedical engineering from Zhejiang University in China and earned a doctorate in biochemistry and molecular biology as well as a masters degree in business administration from Purdue University. He also holds a masters degree in plant physiology from the Chinese University of Hong Kong. Xu is fluent in English, Mandarin and Cantonese. Xu will relocate to the New Jersey area from Switzerland with his family.

ABOUT THE COMPANY

Ingredion Incorporated (NYSE: INGR) headquartered in the suburbs of Chicago, is a leading global ingredient solutions provider serving customers in more than 120 countries. With 2019 annual net sales of more than $6 billion, the company turns grains, fruits, vegetables and other plant-based materials into value-added ingredient solutions for the food, beverage, animal nutrition, brewing and industrial markets. With Ingredion Idea Labsinnovation centers located around the world and more than 11,000 employees, the Company co-creates with customers and fulfills its purpose of bringing the potential of people, nature and technology together to make life better. Visitingredion.comfor more information and the latest Company news.

CONTACTS:Investors: Tiffany Willis, 708-551-2592Media: Becca Hary, 708-551-2602

See more here:
Jeremy Xu Joins Ingredion as Senior Vice President and Chief Innovation Officer - GlobeNewswire