All posts by medical

Johns Hopkins Universitys Biomedical Careers Initiative, a Robust Ph.D. Talent Pipeline for the Regions Life Science Industry – BioBuzz

For Ph.D. students, deciding to leave the familiar environment of academia to pursue a career in the industry can be daunting. Often, Ph.D. students are so engrossed in their academic work they are simply unsure of what non-academic opportunities are out there and dont know how to explore or test these options.

The Johns Hopkins University (JHU ) Biomedical Careers Initiative, or BCI, is a robust internship program that exists to help JHU biomedical Ph.D. candidates and postdoctoral fellows better understand career options outside of academia while also providing real-world, industry experiences to explore and assess.

BCI provides opportunities for students to go out and test what might be a great fit for them. When youre in the lab working toward your PhD you get to see what academia is like but you might also have an interest in working in science policy, for example. You might get to attend an info session to hear about working at a venture capital firm, but that doesnt allow you to experience working there yourselfWe want to provide an opportunity for students to actually go and experience a job and prototype it to see if its a great fit, stated Dr. Rhiannon Mayhugh, Assistant Director of Experiential Learning at JHU School of Medicines (SOM) Professional Development and Career Office (PDCO).

We want our interns to build new skills in their chosen field, which they can bring back to the lab and make them more competitive in the job market. We also encourage students to do informational interviews during the internship to help them build their professional network, which is another important part of career exploration and making the transition into a new field, she added.

The program launched in 2013 and is housed within the PDCO. Dr. Peter Espenshade, JHU SOMs current Associate Dean for Graduate Biomedical Education and Professor of Cell Biology, and Dr. Arhonda Gogos, current JHU SOM Deputy Director of the Biochemistry, Cellular and Molecular Biology Graduate Program, spearheaded BCIs creation. The program was initially supported by the JHU Office of the Provosts Ph.D. Professional Development Innovation Initiative, which still supports the program in its effort to ensure that Johns Hopkins Ph.D. students, while immersed in their training, can learn about, have exposure to, and begin to explore a range of career options relevant for their field, and for their lives.

Since 2013, BCI has helped more than 80 JHU trainees obtain paid internship positions across a wide range of non-academic, industry fields, including biotechnology and pharma, science policy, and consulting, among others. The program is highly structured and designed to provide tailored support to both interns and BCI intern host companies, which include some of the BioHealth Capital Regions (BHCR) best-known companies.

The PDCO office encourages Ph.D. students to start exploring career options and thinking about internships early on when they are in their first or second year. This allows them to plan ahead for their internships that are typically engaged in the later years of their training. Mayhugh meets with Ph.D. students interested in the internship program to do some discovery about their goals, timing, and needs. She also helps interns with developing their resumes, coordinating with their lab and mentors to ensure continuity between the internship and their Ph.D. work, and preparing for internship interviews. Mayhugh and BCIs goal is to make the internship application process as close to a real job application process as possible.

BCI also puts a strong emphasis on assisting interns with making the transition from an academic environment to an industry culture, which can be challenging for some Ph.D. candidates.

There is a lot of uncertainty. There is some fear of the unknown at first. Being able to test something out can help break down some of these fears and possible myths about working in the industry. An internship can really demystify the industry and help interns make a more informed decision, stated Mayhugh.

For BCI partner organizations seeking to hire interns, BCI and Mayhugh handle a great deal of the intern coordination and administrative work to save partner organizations time. For example, Mayhugh markets internship openings to PhDs for host organizations using listserve communications. Whats more, BCI interns can stay on their JHU stipend and health benefits during their 3-month, full-time internship; BCI only requests reimbursement from host organizations post-internship, which simplifies the entire process.

Former BCI interns speak glowingly about the program and how it helped them crystallize their goals and paved the way for their current careers in the industry.

Former BCI intern Dr. Leo Hagmann, who is now a Senior Scientist at Thrive Earlier Detections Baltimore location, shared this about his internship experience: The BCI really allows students a low-risk way to experience these careers immersively, while handling the administrative overhead around health insurance, compensation, and leave timing. The selection of sponsoring organizations the BCI assembled was of high quality while providing a diversity of sectors to choose from, and my experience turned out to be even better than I had hoped.

The biggest thing that the BCI internship helped me see was that a career in science outreach was possible. I had long assumed I would continue doing outreach as a hobby while working some other job. Thanks to the internship I did with the American Society for Biochemistry and Molecular Biology, I was able to experience what a science outreach career looks like and be competitive when applying for positions while finishing up my Ph.D., shared Dr. Lily Raines, who is currently the Manager of the Office of Science Outreach at the American Chemical Society.

Current Booz Allen Hamilton (BHA) Associate and former BCI BHA intern Felix Yu shared, As a graduate student, my primary concerns when considering a non-academic career in the industry were whether my existing skillset from graduate school was translatable and whether Ill receive support from my thesis PI and/or administrators at the UniversityThe steps to initiate and gather relevant resources from scratch were the most daunting and difficult.

The BCI team offered me insight, comfort, and support to navigate the transition. I had the privilege to work with Pat Phelps and Caroline Pounds (ex-assistant Director) in the past and our working sessions offered me a safe space to rediscover my own abilities and limits outside of my thesis lab. From our conversations, I became more confident and was able to prepare myself more efficiently for the consulting industry. More importantly, they assisted me with working through any internship requirements with my thesis PI and department administrators, which alleviated any stress and potential complications, added Yu.

BCI does a great job connecting Ph.D. candidates to the many opportunities across so many non-academic, innovative fields in the region. Part of what makes our internship program great is that a lot of our opportunities are within commuting distance of Johns Hopkins. There are also so many Hopkins alumni that stay in the area so our interns can really utilize our alumni network, stated Mayhugh.

The BCI program tries to facilitate the internship process to make it as easy as possible for the student and the host organization while remaining flexible for each, she added. We want our interns and host organizations to have great experiences that add value and are mutually beneficial.

BCI recruits interns for summer, fall, and winter/spring cycles and the internship program is still placing Ph.D. students at host companies despite COVID-19, as internships have moved to a virtual format to adhere to pandemic safety protocols and policies for the time being.

If youre a current JHU Ph.D. student or post-doctoral fellow, or a company looking to become a BCI partner/host organization, please contact the BCI program at bci@jhmi.eduPh.D. students can review current internship openings you can click here.

Steve has over 20 years experience in copywriting, developing brand messaging and creating marketing strategies across a wide range of industries, including the biopharmaceutical, senior living, commercial real estate, IT and renewable energy sectors, among others. He is currently the Principal/Owner of StoryCore, a Frederick, Maryland-based content creation and execution consultancy focused on telling the unique stories of Maryland organizations.

View post:
Johns Hopkins Universitys Biomedical Careers Initiative, a Robust Ph.D. Talent Pipeline for the Regions Life Science Industry - BioBuzz

Live-Cell Imaging Market Size By Product Analysis, By Application, By End-Users, By Regional Outlook, By Top Companies and Forecast to 2027 – Bulletin…

New Jersey, United States,- The Live-Cell Imaging Market is predicted by Verified Market Researchs report to find players focusing on new product development to secure a strong position in terms of revenue sharing. Strategic collaboration can be a powerful way to bring new products to the market. The level of competition observed in the market may increase.

This research report categorizes the global market by players/brands, regions, types, and applications. The report also analyzes the global market status, competitive landscape, market share, growth rate, future trends, market drivers, opportunities and challenges, sales channels, five forces of distributors, and porters.

The latest 2020 edition of this report reserves the right to provide further comments on the latest scenarios, recession, and impact of COVID-19 on the entire industry. It also provides qualitative information on when the industry can rethink the goals the industry is taking to address the situation and possible actions.

The report covers extensive analysis of the key market players in the market, along with their business overview, expansion plans, and strategies. The key players studied in the report include:

Live-Cell Imaging Market Segment Analysis-

The research report includes specific segments by Type and Application. Each type provides information about the production during the forecast period of 2015 to 2027. The application segment also provides consumption during the forecast period of 2015 to 2027. Understanding the segments helps in identifying the importance of different factors that aid market growth.

Global Live-Cell Imaging Market, By Product

Instruments Consumables Software

Global Live-Cell Imaging Market, By Application

Drug Discovery Developmental Biology Cell Biology Stem Cell Biology

Global Live-Cell Imaging Market, By End User

Academic & Research Institutes Pharmaceutical & Biotechnology Companies Academic & Research Institutes

The study analyses the following key business aspects:

Analysis of Strategies of Leading Players: Market players can use this analysis to gain a competitive advantage over their competitors in the Live-Cell Imaging market.

Study on Key Market Trends: This section of the report offers a deeper analysis of the latest and future trends of the Live-Cell Imaging market.

Market Forecasts:Buyers of the report will have access to accurate and validated estimates of the total market size in terms of value and volume. The report also provides consumption, production, sales, and other forecasts for the Live-Cell Imaging market.

Regional Growth Analysis:All major regions and countries have been covered in the report. The regional analysis will help market players to tap into unexplored regional markets, prepare specific strategies for target regions, and compare the growth of all regional markets.

Segmental Analysis:The report provides accurate and reliable forecasts of the market share of important segments of the Live-Cell Imaging market. Market participants can use this analysis to make strategic investments in key growth pockets of the Live-Cell Imaging market.

Business Opportunities in Following Regions and Countries:

North America (United States, Canada, and Mexico)

Europe (Germany, UK, France, Italy, Russia, Spain, and Benelux)

Asia Pacific (China, Japan, India, Southeast Asia, and Australia)

Latin America (Brazil, Argentina, and Colombia)

How will the report assist your business to grow?

The document offers statistical data about the value (US $) and size (units) for the Live-Cell Imaging industry between 2020 to 2027.

The report also traces the leading market rivals that will create and influence the Live-Cell Imaging business to a greater extent.

Extensive understanding of the fundamental trends impacting each sector, although greatest threat, latest technologies, and opportunities that could build the global Live-Cell Imaging market both supply and offer.

The report helps the customer to determine the substantial results of major market players or rulers of the Live-Cell Imaging sector.

Reason to Buy this Report:

Save and reduce time carrying out entry-level research by identifying the growth, size, leading players, and segments in the global Live-Cell Imaging Market. Highlights key business priorities in order to assist companies to realign their business strategies. The key findings and recommendations highlight crucial progressive industry trends in Live-Cell Imaging Market, thereby allowing players to develop effective long term strategies.

Thank you for reading our report. The report is available for customization based on chapters or regions. Please get in touch with us to know more about customization options, and our team will ensure you get the report tailored according to your requirements.

About us:

Verified Market Research is a leading Global Research and Consulting firm servicing over 5000+ customers. Verified Market Research provides advanced analytical research solutions while offering information enriched research studies. We offer insight into strategic and growth analyses, Data necessary to achieve corporate goals, and critical revenue decisions.

Our 250 Analysts and SMEs offer a high level of expertise in data collection and governance use industrial techniques to collect and analyze data on more than 15,000 high impact and niche markets. Our analysts are trained to combine modern data collection techniques, superior research methodology, expertise, and years of collective experience to produce informative and accurate research.

Contact us:

Mr. Edwyne Fernandes

US: +1 (650)-781-4080UK: +44 (203)-411-9686APAC: +91 (902)-863-5784US Toll-Free: +1 (800)-7821768

Email: [emailprotected]

Read the original:
Live-Cell Imaging Market Size By Product Analysis, By Application, By End-Users, By Regional Outlook, By Top Companies and Forecast to 2027 - Bulletin...

Hereditary Disease Foundation Launches Fund in Honor of Biomedical Pioneer and Huntington’s Disease Researcher Nancy S. Wexler – BioSpace

NEW YORK, Aug. 18, 2020 /PRNewswire/ -- The Hereditary Disease Foundation today announced that it is establishing a research fund to honor Dr. Nancy S. Wexler, a world recognized leader in genetics who led an international team that in 1993 identified the gene that causes Huntington's disease, a devastating inherited neurodegenerative disorder. The fund is being launched with $350,000 in gifts and pledges. In the last two years, the foundation has provided over $3 million for research worldwide.

Dr. Wexler is President of the Hereditary Disease Foundation, which funds innovative research to find treatments and cures for Huntington's disease and impact other brain disorders. She recently revealed that she has been diagnosed with Huntington's disease, the illness she has spent her life studying.

The Nancy S. Wexler Discovery Fund will encourage research collaborations and the recruitment of young scientists. Each year the fund will award the Nancy S. Wexler Young Investigator Prize to a researcher whose work reflects the highest caliber of excellence, diligence and creative thinking. The fund will also support scientific collaborations, educational workshops and conferences.

"Nancy Wexler is celebrating her 75th birthday this year, and there is no more fitting way to honor her pioneering work, relentless dedication and enduring optimism than by establishing this fund in her name," said Meghan Donaldson, CEO of the Hereditary Disease Foundation. "We thank our contributors and friends for their support of our work, moving us toward the day when families will no longer have to face the terrible challenge of Huntington's disease."

Recipient of Young Investigator Prize "The fund honors Nancy Wexler's unparalleled contributions to Huntington's disease research and her extraordinary ability to recruit young, talented scientists to the field and build research collaborations," said Dr. Anne B. Young, Chair of the Hereditary Disease Foundation Scientific Advisory Board and Vice Chair of the HDF Board of Directors. "We are thrilled to present the first Nancy S. Wexler Young Investigator Prize to Dr. Osama Al-Dalahmah, whose brilliant work is bringing us closer to new therapies and potential cures for Huntington's disease."

Dr. Al-Dalahmah, neuropathology instructor in the department of pathology and cell biology at Columbia University Irving Medical Center, is being recognized for his work to discover ways of increasing the brain's ability to protect itself from damage caused by Huntington's disease. He is studying astrocytes the major support cells in the brain that ensure the proper functioning of neurons and their role in the progression of Huntington's disease.

"I believe that bringing astrocytes into the spotlight will open new therapeutic avenues for people with Huntington's disease. Huntington's disease changes astrocytes in several ways, some of which may be neuroprotective and beneficial for neurons," said Dr. Al-Dalahmah. "Tapping into the neuroprotective potential of astrocytes in Huntington's disease will bring us much needed hope. The Hereditary Disease Foundation especially Dr. Nancy Wexler makes my research possible and is the reason why I joined the ranks of Huntington's disease researchers," he added.

Searching for Treatments and Cures for a Devastating Disease Huntington's disease causes irreversible declines in control of mood, memory, and movement. There is currently no cure. Each child of a parent affected with Huntington's disease has a 50% risk of inheriting the same lethal affliction. The disease usually appears in the prime of life age 30-50 but it can strike as early as 2 or as old as 80. It is invariably fatal over 10 to 20 years. Most individuals in the late stages of the disease lose the ability to walk, talk and feed themselves, but are still aware of themselves and their families. Since Huntington's disease is caused by a single gene, it serves as a model to potentially unlock cures for other brain disorders such as Parkinson's, Alzheimer's and Lou Gehrig's (ALS) diseases.

About the Hereditary Disease Foundation The Hereditary Disease Foundation (HDF) was established in 1968 by Dr. Milton Wexler after his wife Leonore was diagnosed with Huntington's disease, which meant their daughters Alice and Nancy were also at risk. From 1979 to 2002, Dr. Nancy Wexler led an international team of scientists and doctors to Venezuela, which has the world's highest prevalence of the disease, to gather clinical data working with thousands of Huntington's disease patients and their families. In 1983, HDF-supported researchers discovered the neighborhood of the Huntington's disease gene using DNA markers, the first marker for any genetic disease. As a result of this discovery, a genetic test for Huntington's disease was developed. This breakthrough also helped launch the Human Genome Project. After finding the marker, the HDF formed the Gene Hunters, a collaboration of 100 international scientists who, over the next decade, pioneered many technologies for mapping and finding genes. In 1993, they identified the Huntington's disease gene. This discovery laid the foundation for all research on Huntington's disease. Today, techniques such as gene silencing and gene editing are being studied and developed, and several clinical trials in humans are now underway.

View original content to download multimedia:http://www.prnewswire.com/news-releases/hereditary-disease-foundation-launches-fund-in-honor-of-biomedical-pioneer-and-huntingtons-disease-researcher-nancy-s-wexler-301113983.html

SOURCE Hereditary Disease Foundation

Read more from the original source:
Hereditary Disease Foundation Launches Fund in Honor of Biomedical Pioneer and Huntington's Disease Researcher Nancy S. Wexler - BioSpace

Recursion and University of Utah launch regions largest life science incubator – Newswise

Newswise Altitude Lab announced its first resident companies and opened applications for its breakthrough collaborative facility and program. Founded by Recursion and the University of Utahs Center for Technology & Venture Commercialization (TVC), the incubator fills the critical role of finding, supporting, incubating and accelerating early-stage life science and health care companies in Utah. Altitude Lab is the first of its kinda blended incubator/accelerator program focused on developing diverse and inclusive businesses in the health care sector.

Were focused on where innovation and economic growth truly startfounders, explained Chandana Haque, executive director of Altitude Lab. We see an opportunity in Salt Lake City to propel global health care innovation by meeting the needs of a diverse community of entrepreneurs.

Altitude Lab brings together important elements to address critical gaps for founders, both in Utah and in the sector. As residents of the incubator, founders will have access to a cutting-edge 14,500-square-foot facility equipped with nearly a million dollars of the latest molecular and cell biology tools, laboratory space and modern office and networking facilities. Altitude will also offer workshops, mentoring and non-dilutive funding designed to address the opportunity gap experienced by underrepresented founders. Half of resident companies will have an underrepresented founder or executive and one third will receive grants that cover the cost of residency.

Altitude Lab is bringing together resources and a community that many startups lack, but were pivotal to Recursions success, said Chris Gibson, co-founder and CEO of Recursion. Together with the university and other partners, we can help reduce the friction of finding key assets, like lab space and capital, for a new generation of diverse companies and founders. Its an approach that we see transforming the industry in this region.

Utah is a substantial source of innovation, as TVC has launched more than two hundred companies in just the last decade, one of which was Recursion, said Keith Marmer, associate vice president for technology & venture commercialization and corporate partnerships at the U. We understand that one of greatest obstacles to building a company is finding affordable lab and office space, so Altitude Lab is providing the region with an important building block to nurture and accelerate ideas to market.

The incubators first companies include:

Altitude Lab will officially open its collaborative wet lab facility in October to enable therapeutic, diagnostic, medical device, research tools and health tech companies.

Learn more about Altitude Lab and apply for residency ataltitudelab.org.

About Altitude Lab

Altitude Lab is building a new, representative generation of founders to seed the next cycle of biotech innovation in Salt Lake City. Located in University of Utah Research Park, Altitude Lab is an incubator focused on early stage life science and health care companies. The initiative is part of alarger city planandcollaborative visionfrom Recursion and the University of Utah to foster socially-responsible entrepreneurship, job creation, and economic productivity. The Recursion Charitable Foundation, under which Altitude Lab operates, has filed for 501(c)(3) status and currently operates as a nonprofit organization. Learn more ataltitudelab.orgor connect onTwitter.

About Recursion

Recursion is a clinical-stage biotechnology company combining experimental biology and automation with artificial intelligence in a massively parallel system to efficiently discover potential drugs for diverse indications, including genetic disease, inflammation, immunology and infectious disease. Recursion applies causative perturbations to human cells to generate disease models and associated biological image data. Recursions rich, relatable database of more than 5 petabytes of biological images generated in-house on the companys robotics platform enables advanced machine learning approaches to reveal drug candidates, mechanisms of action and potential toxicity, with the eventual goal of decoding biology and advancing new therapeutics to radically improve lives. Recursion is headquartered in Salt Lake City. Learn more atrecursionpharma.com, or connect onTwitter,Facebook, andLinkedIn.

About the Center for Technology & Venture Commercialization

The Center for Technology & Venture Commercializationis dedicated to helping the University of Utahs faculty inventors bring their innovations to market. TVC is responsible for all aspects of invention management, patent prosecution, licensing, startup formation and support, equity management and early-stage funding. The centers mission is to generate economic returns for the university and the state of Utah, expand the universitys reputation for innovation and positively impact society. The University of Utah was recentlyrankedas the 30th-most innovative university in the world by Reuters.

Follow this link:
Recursion and University of Utah launch regions largest life science incubator - Newswise

More Talent Rushes To The Synthetic Biology Gold Mine: Venture Capitalist Mitchell Mutz Leaves Roche To Join Codon Capital – Forbes

Synthetic biology sells picks and shovels for the $4 trillion bioeconomy, and Codon Capital sees ... [+] this opportunity. Mitchell Mutzthe accomplished venture investor, biotech serial entrepreneur, and inventorjoins Codon Capital to build a better world with biology.

Synthetic biology sells picks and shovels for the $4 trillion bioeconomy, and Codon Capital sees this opportunity. Its investments are a who's who of synthetic biology, including up-and-coming unicorns Pivot Bio, Zymergen, Bolt Threads, and more. Now, Codon Capital and its founder, Karl Handelsman, have attracted new talent. Mitchell Mutzthe accomplished venture investor, biotech serial entrepreneur, and inventorhas departed Roche Venture Fund to join Codon Capital at its San Francisco-based office.

If you follow my column, you know that synthetic biology is a fast-growing field at the forefront of manufacturing. It combines computation, automation, and our ability to read/write/edit DNA to make sustainable, high-performance products with biology. This includes better pharmaceuticals and diagnostics for Covid-19, smart drugs for cancer and diabetes, and products we dont associate with biotech like cars, sports apparel, and cell phones.

Mitchell Mutz joined Codon Capital to pursue a simple investment thesis: back great technology teams ... [+] that make the impossible possible.

Mutz has firsthand experience in this industry. He was the first employee at Labcyte, a company developing revolutionary lab equipment for scientific research, which two years ago exited with an impressive sale to Beckman Coulter for $310 million. In addition to being Labcytes first employee, Mutz also founded Amplyx Pharmaceuticals in 2007, a small molecule therapeutics company that has raised over $140 million in venture financing and recently completed a phase two clinical trial. After three and a half years as senior investment director at Roche Ventures, hes joining the Codon Capital team, focusing on therapeutics and synthetic biology.

With a Ph.D. in chemistry from the University of Rochester, experience working in midsize biotech companies, and 36 issued patents, Mutz sees himself as an investor, serial entrepreneur, and inventor. His expertise and long-time connection to Handelsman make him excited about his new role at Codon Capital.

I'm a huge synthetic biology fan. I've been thrilled beyond belief, although we didn't envision at the time how much Labcyte has become involved with being an engine for synthetic biology, says Mutz. I'm very excited to be more active in that space.

Although the economic outlook is a little more uncertain now, Handelsman sees no need to put his foot on the brake.

Karl Handelsman, founder of Codon Capital and synthetic biology investor, at SynBioBeta

Even though it is a time of turmoil, the need for early-stage innovation has never been greater, says Handelsman. This is a time when entrepreneurs and investors are stepping up to do even bolder things. It's a tough time, but its a very good time to start things. We need more innovation, and entrepreneurs have a robust desire to build out really important companies.

What does Codon Capital look for in biotech companies? In a challenging technical and economic landscape, Handelsman says Codon Capitals investment thesis is simple: We back great technical teams to make the impossible possible.

Mutz and Handelsman are not the only ones who see this young industrys potential: synthetic biology investment has topped $18 billion over the last ten years. Whether it's improving humans lives, sustaining the planet, or capitalizing on the coming bio-industrial revolution, more and more investors see synthetic biology as the ultimate enabling technology of the triple bottom line.

Follow me on Twitter at @johncumbers and @synbiobeta. Subscribe to my weekly newsletters in synthetic biology. Thank you to Stephanie Michelsen for additional research and reporting in this article. Im the founder of SynBioBeta, and some of the companies that I write about are sponsors of the SynBioBeta conference and weekly digest. Heres the full list of SynBioBeta sponsors.

Read the original:
More Talent Rushes To The Synthetic Biology Gold Mine: Venture Capitalist Mitchell Mutz Leaves Roche To Join Codon Capital - Forbes

College of Health and Human Performance – University of Florida

August 17, 2020

Previous studies showed nitrate was helping muscles by improving use of calcium in the muscle. This finding that its additionally affecting power is significant, especially in the context of COVID-19, because the diaphragm is the primary inspiratory muscle used for breathing and coughing, the latter being relevant for clearing the lungs.

The research team at the University of Florida found that dietary nitrate supplementation elicited a pronounced increase in contractile function (power) of the diaphragm, a respiratory muscle, of old mice.

They made their measurements during maximal activation, so the effects observed seem to be caused by an improvement in the function of contractile proteins rather than calcium handling.

Few short-term interventions have such a profound impact on muscle contractile function, as was observed in this study.

Dietary nitrate is readily available for humans and could be used, under proper supervision, to improve respiratory muscle dysfunction that contributes to shortness of breath and morbidity in the elderly.

The researchers gave sodium nitrate to old mice in their drinking water daily for 14 days. The control group received regular water. Diaphragm muscle contractile function cannot be assessed directly in live animals or humans. Thus, they tested diaphragm function in muscle tissues under controlled conditions for muscle stimulation and oxygenation.

The main limitations are that mouse and human diaphragm have different percentages of fast and slow muscle cells. Mouse diaphragm consists of 90% fast muscle cells; the human diaphragm consists of 25-50% fast muscle cells depending on several factors that include and age and sex.

Dietary nitrate seems to exert a greater impact on the contractile function of fast muscle cells. Thus, the benefits to the human diaphragm may not as pronounced as was observed in mice. They also only tested male mice, and the benefits for females is unknown.

Leonardo Ferreira, Ph.D., associate professor in the Department of Applied Physiology andKinesiology and senior author on the study said:

Our findings are especially important in light of the current COVID-19 pandemic as they suggest that, if replicated in humans, dietary nitrate is useful to improve respiratory muscle dysfunction that contributes to difficulty in weaning patients from mechanical ventilation.

The article is available at physoc.onlinelibrary.wiley.com.

Read more HHP News >

Original post:
College of Health and Human Performance - University of Florida

Acidic niche within lymph nodes plays integral role in regulating T cell activation – News-Medical.Net

In the fight against cancer, the immune system is the first line of defense. The lymphatic system specifically is essential to protecting the body against foreign invaders. Activation of immune cells in the lymph nodes leads to the production and release of antibodies, and activation of lymphocytes, including T cells, to battle infection.

But little is known about how activation of immune cells in the lymph nodes can occur without enabling effector functions that could also damage the lymphatic system.

In a new article published in Nature Communications, Moffitt Cancer Center researchers describe a novel acidic niche within lymph nodes that plays an integral role in regulating T cell activation.

Acidosis is a potent inhibitor of effector T cell functions. Oxygen levels are reported to be low in lymph nodes and that hypoxic tissue is acidic. We wanted to determine if lymph nodes were also acidic."

Robert Gillies PhD, Chair, Department of Cancer Physiology,H. Lee Moffitt Cancer Center & Research Institute

For this study, Moffitt researchers used fluorescence and magnetic resonance imaging to identify a naturally occurring acidic niche within lymph nodes. Upon further analysis, they discovered that the T cells were the source of that acidity. They say the results pinpoint localized acidosis as a critical component of the adaptive immune response.

The findings demonstrate the potential role for the lymph node microenvironment in shaping T cell biology. T cells activated by antigen-presenting cells, such as dendritic cells, produce an acidic environment that is balanced by the enhanced capacity to generate lactic acid.

"The low extracellular pH of lymph nodes does not impair the T cell's activation, but it does suppress the cytokine production, which is likely what protects lymph nodes from being attacked by the immune system," said Gillies.

The researchers say this robust physiological mechanism can be exploited by cancers, resulting in evasion of immune surveillance by malignant tissue and tumors. They believe this could be managed by manipulating the acidity in combination with immunotherapies such as T-cell checkpoint blockade therapy. However, more research is needed to confirm.

Source:

Journal reference:

Wu, H., et al. (2020) T-cells produce acidic niches in lymph nodes to suppress their own effector functions. Nature Communications. doi.org/10.1038/s41467-020-17756-7.

Originally posted here:
Acidic niche within lymph nodes plays integral role in regulating T cell activation - News-Medical.Net

Headwall Partner Purdue Univ to Help Develop Internet of Things for Precision Agriculture – GlobeNewswire

Headwall Photonics lightweight hyperspectral UAV takes off for a flight above an experimental agricultural field.Photo courtesy geo-konzept GmbH, 2020

Bolton, MA, Aug. 18, 2020 (GLOBE NEWSWIRE) -- Headwall Photonics, a world leader in hyperspectral imaging systems and solutions, announced today that a close technology partner, Purdue University, has been chosen by the National Science Foundation (NSF) as a key member of a new Engineering Research Center (ERC) dedicated to significant improvements in agriculture as a part of ensuring long-term food, energy, and water security.

The NSF ERC for the Internet of Things for Precision Agriculture (IoT4Ag) unites faculty and students from the University of Pennsylvania, Purdue University, the University of California at Merced, and the University of Florida with government and industry partners. Staff will utilize technology such as Headwalls hyperspectral sensors integrated onto unmanned aerial vehicle (UAV) systems to create data-driven models to capture and analyze plant physiology, soil properties, management and environmental variations.

We are excited about our partnership and we look forward to continuing our work with Headwall to maximize the impact and success of IoT4Ags technologies, education, and diversity, equity, and inclusion activities, says Melba Crawford, the Nancy Uridil and Francis Bossu Professor in Civil Engineering, and professor of agronomy and electrical and computer engineering at Purdue.

The ERC will also leverage Purdues commitment to plant science and our focus on digital agriculture. We are excited about the collaboration with our university and industrial partners to advance technology in environmental sensing, robotics, and data science in precision agriculture to help meet the demands for food production in the upcoming decades.

David Bannon, President & CEO of Headwall, is equally enthusiastic: This is one of the more prestigious and impactful partnerships that we have undertaken. A core strength of our company is providing remote-sensing solutions for customers within the agritech community. We also look forward to applying Headwall spectral imaging solutions to important problem areas to drive improved crop yield and enhanced phenotype resiliency."

About the College of Agriculture at Purdue University

Purdue Universitys College of Agriculture is one of the worlds leading colleges of agricultural, food, life, and natural resource sciences. As a land-grant institution, we are committed to preparing our students to make a difference, wherever their careers take them; stretching the frontiers of science to find solutions to some of our most pressing global challenges; and, through Purdue Extension and engagement programs, helping the people of Indiana, the nation and the world improve their lives and livelihoods.

About The NSF ERC IoT4Ag

The NSF Engineering Research Center (ERC) program supports convergent research, education, and technology translation at U.S. universities that will lead to strong societal impacts.Each ERC has interacting foundational components that go beyond the research project, including engineering workforce development at all participant stages, a culture of diversity and inclusion where all participants gain mutual benefit, and value creation within an innovation ecosystem that will outlast the lifetime of the ERC. IoT4Ag seeks to ensure food, energy, and water security with new systems to increase crop production while minimizing energy and water use and environmental impacts of agricultural practices.

About Headwall

Based in Massachusetts, Headwall is a leading designer and manufacturer of complete spectral instrumentation solutions for remote sensing, advanced machine vision, and government/defense markets. With a worldwide base of end-user and OEM customers, Headwall enjoys a market leadership position through the design and manufacture of spectral solutions that are customized for application-specific performance. With a worldwide presence, Headwall maintains offices in 3 European locations and an office in Taiwan. For more information, visitwww.headwallphotonics.com.

Originally posted here:
Headwall Partner Purdue Univ to Help Develop Internet of Things for Precision Agriculture - GlobeNewswire

Fall 2020 classes begin at Wallace State with in-person, hybrid and online options – Cullman Times Online

The usual first-day nerves were there for some returning and new Wallace State Community College students, but for the most part, most were excited to be on campus and starting classes. While most academic classes will be taught online, technical and health science classes that require hands-on learning for skills welcomed students in hybrid classes to campus on Monday.

Emily Knighten of Falkville said she was excited but nervous to be starting her classes in the Medical Assisting program and was glad to be on campus. Im glad to be able to be here, she said. Knighten completed a short-term certificate for Medical Lab Assistant the previous semester and chose to come back to start the Medical Assistant program at the urging of coworkers at the urgent care facility where she works.

Fellow Medical Assistant student Yeniveth Benitez of Hanceville entered the program after seeing the success her sister Yadira had with it. She had a good job and she only went to school a year and a half and I wanted follow in her footsteps because shes like a mom figure to me, Benitez said. A true freshman who recently graduated from Hanceville High School, she said she was excited to be starting college classes.

Second-year Dental Hygiene student, Madisyn Bedingfield of Madison, prepped for the day by disinfecting all the surfaces of her assigned station.

Im really excited, she said. I cant wait to finish and get my license and finally get to be practicing.

Bedingfield said she appreciated everything faculty and staff did at the end of the spring semester when COVID-19 impacted their classes.

I think the faculty did a wonderful job, she said. Honestly, they had us back as soon as we could and were sending us emails and keeping us updated. Even though we had to be online, the teachers were great and really understanding in helping us as much as they could. Then we had to take our tests online. That was a challenge, but we all worked through it together.

Stephen Gholson of Springville was taking his first classes on the Hanceville campus, having previously taken classes at the Oneonta campus. Transferring from Jacksonville State University where he was a business major, Gholson is taking prerequisite courses at Wallace State to transfer to UAB to get a masters in Nursing.

So far its been a fairly easy process to get started, he said. I was able to apply and register in a total of like five days.

Collision Repair student Mario Ralius of Blountsville was returning for his third semester at Wallace State. I really enjoy the Collision Repair program, he said. Its a lot of fun. I have learned a lot and especially a lot about welding on vehicles.

Natural Science Department Chair Beth Williams was pleased with her first class of the day. Most of her Anatomy and Physiology students logged on to take part in their class and were active in asking questions through the online format, she said.

Registration is continuing for the Fall 2020 semester for Regular and Mini Term I, as well as for Flex Start Courses and Mini Term II. Registration for Flex Start I courses will be from Aug. 24-28 and from Aug. 31-Sept. 4 for Flex Start II courses. Students who register for the Flex Start courses complete those online through the end of the regular term on Dec. 16. Mini Term II courses will be held from Oct. 14 to Dec. 16.

The campus remains open for students who need to come to meet instructors, or use student services such as Lion Central, library, tutoring lab, etc. Masks and self-screening are required by all who come to campus. Support is also available virtually via http://www.wallacestate.edu/virtual-student-services.

Learn more and view a video message from Wallace State President Vicki Karolewics at wallacestate.edu/coronavirus.

We are making critical coverage of the coronavirus available for free. Please consider subscribing so we can continue to bring you the latest news and information on this developing story.

See the rest here:
Fall 2020 classes begin at Wallace State with in-person, hybrid and online options - Cullman Times Online

International Project to Delve Into the Mysteries of Brain Connections – UT News | The University of Texas at Austin

AUSTIN, Texas Researchers at The University of Texas at Austin will lead an ambitious new project with 10 other U.S. institutions that has significant implications for understanding human brain health.

With support from the Next Generation Networks for Neuroscience (NeuroNex) program at the National Science Foundation (NSF), the team will examine newly discovered complexities related to synapses the tiny structures that form trillions of connections between nerve cells in the brain and allow us to think, sense, learn, act and remember. The partnership, which includes scientists in Germany, the United Kingdom and Canada, hopes to explore new ways to define what determines the strength of synapses and what alters their strength.

Traditionally, synapses have been treated as on or off switches essentially, 1-bit machines but this assumption is wrong, said Kristen Harris,a professor in the UT Department of Neuroscience and the Center for Learning and Memory, who will lead the project. Our team discovered that the information content stored in the size of a synapse can be much higher, already found to be greater than 4 bits in some brain regions. What this outcome means is that synapses are less like light switches and more like dimmer switches that can dial in the desired strength depending on need or mood.

Because new research has found synapses to be far more varied and nuanced than neuroscientists believed five years ago, the new project will examine many aspects of whats known as synaptic weight (or strength). The international scientific team will explore variation among synapses, from the level of molecules to the level of circuits, to determine what differences among them mean for our basic understanding of the brain.

Using multidisciplinary approaches, cutting-edge imaging technologies and cyber resources, the research team will generate data to predict how specific neural circuits form and function. Because recent research has uncovered the important role of differences in synaptic strength, the new project will explore how factors such as size, connectivity, volume, cellular resources and protein composition help shape these nanometer-sized structures and the effects that these differences have in the brain.

Theres still so much we dont know about how the brain works, and one of the keys to unlocking those mysteries is finding out more about specific neural circuits, said NSF NeuroNex Program Director Floh Thiels. This requires bringing together researchers from fields including chemistry, biology and computer science and engineering, and applying the latest analysis techniques to the data they produce. This has been a goal for neuroscientists for years, and what we will see from this network of researchers is a new chapter of international collaboration and coordination.

To compare and map synaptic weights the team is developing a new form of electron microscopy called tomoSEM (tomographic scanning electron microscopy), which will be able to capture information in high resolution and across large field sizes as necessary for the research. Once completed in the Harris lab, tomoSEM will be implemented and tested across labs in this NeuroNex network, and ultimately it will be standardized for general use. The images and tools will be shared with the scientific community on a public website in collaboration with UTs Texas Advanced Computing Center(TACC).

NSF has awarded more than $50 million over five years to four interdisciplinary teams, including $17.5 million for the U.S. component of the team Harris is leading. Collaborators are Alice Ting at Stanford University; Mark Ellisman at the University of California, San Diego; Erik Jorgenson and Bryan Jones the University of Utah; Clay Reid at the Allen Institute for Brain Science; Davi Bock at the University of Vermont; Narayanan Kasthuri at the University of Chicago; Linnaea Ostroff at the University of Connecticut at Storrs; Terrence Sejnowski and Uri Manor at the Salk Institute for Biological Studies; Joshua Vogelstein at Johns Hopkins University; and James Carson at TACC. In addition, Viren Jain at Google (US) will participate in this project.

Read the original post:
International Project to Delve Into the Mysteries of Brain Connections - UT News | The University of Texas at Austin