Grey's Anatomy had a makeshift finale as the ABC medical drama wasn't able to finish filming before lockdown. This means there were a few storylines left on a cliffhanger and unresolved until season 17. However, one story which series 16 will be remembered for is the departure of Dr Alex Karev (played by Justin Chambers).

WARNING: This article contains spoilers from Grey's Anatomy.

Dr Alex Karev had been in Grey's Anatomy since it first began in 2005.

He was one of the key members of staff at the Grey Sloan Memorial Hospital and one of the only original characters on the show.

Alex had been missing from the hospital for several months but an explanation wasn't given as to what happened to him until the episode Leave the Light On.

He had reunited with ex-wife Dr Izzie Stevens (Katherine Heigl) after finding out she was bringing up their five-year-old twins by herself.

When she had cancer in the show, she and Alex froze embryos in case they could never have children and on realising she was infertile, she decided to use them but didn't tell Alex.

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Alex and Jo Wilson's (Camilla Luddington) relationship seemed on the rocks prior to him leaving.

He then told her their relationship was over but didn't reveal why until he sent a letter offering a full explanation.

Alex wanted to be a father to his children as well as getting back together with Izzie so was willing to leave both his job and his wife behind.

Baffled by what had happened, there are now questions over whether Jo will be able to continue working at the hospital after her husband's betrayal.

While her experience at work is going to be very different with Alex no longer around, there has been no confirmation Jo is going to be leaving anytime soon.

In fact, co-star Chris Carmack who plays Dr Atticus "Link" Lincoln, a close friend of Jo's, thinks she will come out better and stronger than before.

Speaking to People magazine, Carmack said: "Jo is a tough character.

She has come so far and has grown so much. Shes a survivor she can stand on her own."

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Carmack continued: "I think shes going to rise from the smoke of all this.

"I dont think you can just crush this one-off, its tough.

"Shes a strong cookie. She has a lot to give to the world and the medical community and to the patients at Grey Sloan.

"I think, as a viewer, shes going to rise and be okay.

Actress Luddington has also expressed her excitement at what's next for her character.

In March, Luddington posted a picture of herself on Instagram reading a script for Grey's Anatomy.

A fan commented about how they were excited to see what was going to happen to Jo and Luddington replied: Omg me too!

The scripts for Jo this season are ??! JUST. WAIT.

So what will become of Jo and how will she cope with the change in the next season?

Grey's Anatomy is available to watch on ABC.

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Grey's Anatomy: Is Jo Wilson leaving Grey's Anatomy after Alex Karev heartbreak? - Express.co.uk