image:

Large chains of migrating cells forming braided streams break down into a shower of young migrating neurons that continue to integrate into the entorhinal cortex and neighboring regions until 2-3 years of age.

Credit: Lab of Shawn Sorrell/Pitt

The human brain continues to be built after we are born for far longer than previously recognized, suggests research by Shawn Sorrells, assistant professor of neuroscience inthe Kenneth P. Dietrich School of Arts andSciences. Sorrellss research on postnatal brain development, published today inthe journalNature, shines light on fundamental processes that contribute to the development of important brain functions, such as learning, memory and spatial navigation.

The new research suggests that a subset of inhibitory neurons within the entorhinal cortex, or EC -- an area of the brain essential for forming memories -- continue to migrate into this region where they build new neuronal connections from birth through toddlerhood. The study suggests that extensive postnatal neuronal migration across the EC might underlie critical neuroplasticity periods during which the brain is especially receptive to changes and adaptations. The discovery also points to a possible reason why EC neurons are more susceptible to neurodegeneration, since other recent studies have found that this same type of neuron is impacted early in Alzheimers disease.

By analyzing brain samples that were provided, in part, by the epilepsy tissue bank at UPMC Childrens Hospital and the Neuropathology Department at UPMC Presbyterian Hospital, Sorrells' research team was first to show that, unlike what was previously thought, neuronal migration of such scale and duration is extensive within regions that control thoughts and emotions. The discovery offers an explanation for how the human brain makes billions of new neurons over a very short time span through a mechanism that allows neurons to continue arriving after birth.

It is generally thought that the brain is done recruiting neurons by the time an individual is born, said Sorrells. We were incredibly excited to learn that not only does large-scale neuronal migration continue into specific brain regions, but that this process also continues into ages when children are crawling and beginning to walk.

Imaging analysis

Human tissue samples

Protracted Neuronal Recruitment in the Temporal Lobe of Young Children

20-Dec-2023

A.A.B is a co-founder and is on the Scientific Advisory Board of Neurona Therapeutics. C.J.Y is a Scientific Advisory Board member for and holds equity in Related Sciences and ImmunAI, a consultant for and holds equity in Maze Therapeutics, and a consultant for TReX Bio. C.J.Y. has received research support from Chan Zuckerberg Initiative, Chan Zuckerberg Biohub, and Genentech

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