Summary: A groundbreaking study successfully restored cognitive function in patients with lasting impairments from traumatic brain injuries using deep-brain-stimulation devices.

This innovative technique targets the central lateral nucleus in the thalamus to reactivate neural pathways associated with attention and arousal.

The studys participants, who had suffered moderate to severe brain injuries, showed remarkable improvements in mental processing speed, concentration, and daily life activities.

These findings offer new hope for individuals struggling with the long-term effects of traumatic brain injuries.

Key Facts:

Source: Stanford

In 2001, Gina Arata was in her final semester of college, planning to apply to law school, when she suffered a traumatic brain injury in a car accident. The injury so compromised her ability to focus she struggled in a job sorting mail.

I couldnt remember anything, said Arata, who lives in Modesto with her parents. My left foot dropped, so Id trip over things all the time. I was always in car accidents. And I had no filter Id get pissed off really easily.

Her parents learned about research being conducted at Stanford Medicine and reached out; Arata was accepted as a participant. In 2018, physicians surgically implanted a device deep inside her brain, then carefully calibrated the devices electrical activity to stimulate the networks the injury had subdued.

She noticed the difference immediately: When she was asked to list items in the produce aisle of a grocery store, she could rattle off fruits and vegetables. Then a researcher turned the device off, and she couldnt name any.

Since the implant I havent had any speeding tickets, Arata said. I dont trip anymore. I can remember how much money is in my bank account. I wasnt able to read, but after the implant I bought a book,Where the Crawdads Sing, and loved it and remembered it. And I dont have that quick temper.

For Arata and four others, the experimental deep-brain-stimulation device restored, to different degrees, the cognitive abilities they had lost to brain injuries years before. The new technique, developed by Stanford Medicine researchers and collaborators from other institutions, is the first to show promise against the long-lasting impairments from moderate to severe traumatic brain injuries.

The results of the clinical trial will be published Dec. 4 inNature Medicine.

Dimmed lights

More than 5 million Americans live with the lasting effects of moderate to severe traumatic brain injury difficulty focusing, remembering and making decisions. Though many recover enough to live independently, their impairments prevent them from returning to school or work and from resuming their social lives.

In general, theres very little in the way of treatment for these patients, saidJaimie Henderson, MD, professor of neurosurgery and co-senior author of the study.

But the fact that these patients had emerged from comas and recovered a fair amount of cognitive function suggested that the brain systems that support attention and arousal the ability to stay awake, pay attention to a conversation, focus on a task were relatively preserved.

These systems connect the thalamus, a relay station deep inside the brain, to points throughout the cortex, the brains outer layer, which control higher cognitive functions.

In these patients, those pathways are largely intact, but everything has been down-regulated, said Henderson, the John and Jene Blume-Robert and Ruth Halperin Professor. Its as if the lights had been dimmed and there just wasnt enough electricity to turn them back up.

In particular, an area of the thalamus called the central lateral nucleus acts as a hub that regulates many aspects of consciousness.

The central lateral nucleus is optimized to drive things broadly, but its vulnerability is that if you have a multifocal injury, it tends to take a greater hit because a hit can come from almost anywhere in the brain, saidNicholas Schiff, MD, a professor at Weill Cornell Medicine and co-senior author of the study.

The researchers hoped that precise electrical stimulation of the central lateral nucleus and its connections could reactivate these pathways, turning the lights back up.

Precise placement

In the trial, the researchers recruited five participants who had lasting cognitive impairments more than two years after moderate to severe traumatic brain injury. They were aged 22 to 60, with injuries sustained three to 18 years earlier.

The challenge was placing the stimulation device in exactly the right area, which varied from person to person. Each brain is shaped differently to begin with, and the injuries had led to further modifications.

Thats why we developed a number of tools to better define what that area was, Henderson said. The researchers created a virtual model of each brain that allowed them to pinpoint the location and level of stimulation that would activate the central lateral nucleus.

Guided by these models, Henderson surgically implanted the devices in the five participants.

Its important to target the area precisely, he said. If youre even a few millimeters off target, youre outside the effective zone.

A pioneering moment

After a two-week titration phase to optimize the stimulation, the participants spent 90 days with the device turned on for 12 hours a day.

Their progress was measured by a standard test of mental processing speed, called the trail-making test, which involves drawing lines connecting a jumble of letters and numbers.

Its a very sensitive test of exactly the things that were looking at: the ability to focus, concentrate and plan, and to do this in a way that is sensitive to time, Henderson said.

At the end of the 90-day treatment period, the participants had improved their speeds on the test, on average, by 32%, far exceeding the 10% the researchers had aimed for.

The only surprising thing is it worked the way we predicted it would, which is not always a given, Henderson said.

For the participants and their families, the improvements were apparent in their daily lives. They resumed activities that had seemed impossible reading books, watching TV shows, playing video games or finishing a homework assignment. They felt less fatigued and could get through the day without napping.

The therapy was so effective the researchers had trouble completing the last part of their study. They had planned a blinded withdrawal phase, in which half the participants would be randomly selected to have their devices turned off.

Two of the patients declined, unwilling to take that chance. Of the three who participated in the withdrawal phase, one was randomized to have their device turned off. After three weeks without stimulation, that participant performed 34% slower on the trail-making test.

The clinical trial is the first to target this region of the brain in patients with moderate to severe traumatic brain injury, and it offers hope for many who have plateaued in their recovery.

This is a pioneering moment, Schiff said. Our goal now is to try to take the systematic steps to make this a therapy. This is enough of a signal for us to make every effort.

Researchers from Weill Cornell Medicine, Spaulding Rehabilitation Hospital in Boston, Harvard Medical School, the University of Utah, the University of Florida, Vanderbilt University, the University of Washington, the University of Bordeaux and the Cleveland Clinic also contributed to the study.

Funding: The study was supported by funding from the National Institute of Health BRAIN Initiative and a grant from the Translational Science Center at Weill Cornell Medical College. Surgical implants were provided by Medtronic.

Author: Nina Bai Source: Stanford Contact: Nina Bai Stanford Image: The image is credited to Neuroscience News

Original Research: Closed access. Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study byJaimie Henderson et al. Nature Medicine

Abstract

Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study

Converging evidence indicates that impairments in executive function and information-processing speed limit quality of life and social reentry after moderate-to-severe traumatic brain injury (msTBI). These deficits reflect dysfunction of frontostriatal networks for which the central lateral (CL) nucleus of the thalamus is a critical node. The primary objective of this feasibility study was to test the safety and efficacy of deep brain stimulation within the CL and the associated medial dorsal tegmental (CL/DTTm) tract.

Six participants with msTBI, who were between 3 and 18 years post-injury, underwent surgery with electrode placement guided by imaging and subject-specific biophysical modeling to predict activation of the CL/DTTm tract. The primary efficacy measure was improvement in executive control indexed by processing speed on part B of the trail-making test.

All six participants were safely implanted. Five participants completed the study and one was withdrawn for protocol non-compliance. Processing speed on part B of the trail-making test improved 15% to 52% from baseline, exceeding the 10% benchmark for improvement in all five cases.

CL/DTTm deep brain stimulation can be safely applied and may improve executive control in patients with msTBI who are in the chronic phase of recovery.

ClinicalTrials.gov identifier:NCT02881151.

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