Nearly all of the original stars of Greys Anatomy have left the show throughout the two decades it has been on television and several of them were actually killed off.

There have been so many major deaths on the Shonda Rhimes series and lots of them have left fans devastated.

Thankfully, quite a few of the departed characters have made return appearances throughout the years and there are even four returning cast members this season so far.

Click through the slideshow to see the 23 major characters who have been killed off

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Every Major 'Grey's Anatomy' Character Who Has Been Killed Off, Ranked from First to Most Recent - Just Jared