AlthoughGreys Anatomyfans only had their belovedGeorge O Malley (T. R. Knight)for five seasons, hes one character viewers will never forget. If it werent for his shy personality,another major character which lasted much longer wouldnt even be on the show.

Fans will never forget the tragic death of George OMalley. He had left the hospital to join the army but gets hit by a bus while saving someone. The young man is rushed to the hospital, but his fellow residents cant tell its him until its too late. O Malley draws the numbers 007 in Meredith Greys (Ellen Pompeo) hand, and thats when she realizes her John Doe is George.

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While his on-screen death was one of the saddest on the show, the reason why T. R. Knight left is more complicated. In 2007, the actors co-star Isaiah Washington, who played Preston Burke, reportedly referred to Knight with a homophobic slur. Washington was fired soon after, but Knight could never get past the incident, forcing him to come out as gay publicly.

He also cited a breakdown in communication with creator Shonda Rhimes and his characters decreased screen time as the reasons he left.

Justin Chambers, who portrayed Alex Karev for 16 seasons of Greys Anatomy, was not in the shows original pilot. After shooting the initial episode, the writers felt that George O Malley needed a male character to play opposite him. George was so shy and kind that they needed someone to balance him out.

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Thats when the character of Alex Karev was created. Instead of filming the entire pilot over again, the producers used CGI to add him in. Although it wasnt evident to fans who watched the show in 2005, looking back on old episodes, viewers can tell something odd is going on.

A whole new scene was filmed with Meredith and Alex, but otherwise, the magic of CGI brought him to life in the pilot.

For fans of the show, the departure of Alex Karev was confusing. He left to take care of his mother in Iowa and never came back. Then reports of Chambers exit began flying around in January 2020. However, when the show came back from winter break on Jan. 23, 2020, there was no mention of Karevs departure.

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On March 5, 2020, fans finally got closure for Alexs storyline. He found out that he had two children with his ex-wife Izzie Stevens, and left Seattle, Washington, to be with them.

Chambers cited the reason for his departure as wanting to branch out into different avenues and spend more time with his family.

Theres no good time to say goodbye to a show and character thats defined so much of my life for the past 15 years,Chambers shared. For some time now, however, I have hoped to diversify my acting roles and career choices. And, as I turn 50 and am blessed with my remarkable, supportive wife and five wonderful children, now is that time.

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'Grey's Anatomy': This 1 Major Character Wouldn't Be on the Show If It Wasn't for George O' Malley - Showbiz Cheat Sheet