Research Fellow, Biology job with MAYNOOTH UNIVERSITY | 354742 – Times Higher Education

Department : Biology Vacancy ID : 025483 Closing Date : 05-Nov-2023

Maynooth University is committed to a strategy in which the primary University goals of excellent research and scholarship and outstanding education are interlinked and equally valued.

The Family Genomics research group led by Dr Lorna Lopez, in collaboration with behavioural neuroscientist Professor Andrew Coogan at Maynooth University invite applications for the position of Research Fellow on our Ambient-BD research project.

This project is led by the University of Edinburgh with co-investigators at Maynooth University, Ireland and the Technical University of Munich, Germany. It is funded by the Wellcome Trust (2023-2028).The purpose of Ambient-BD is to investigate the role of variability in long-term circadian rhythms in the trajectory of disease in people with bipolar disorder.

The initial development and validation studies will be carried out in Maynooth University and the clinical studies in people with bipolar disorder completed at the University of Edinburgh. There will be considerable collaboration between the two research sites throughout the project.

Bipolar disorder is defined by extreme variability in mood, activity, sleep and circadian timing recurring over weeks and months. The purpose of Ambient-BD is to optimise innovative ambient and passive methods for collection of circadian data and to test their feasibility and performance against gold standards. A lived experience advisory panel will help us to identify and prioritise clinical and functional outcome measures to co-produce low intensity methods for collecting these outcomes. In parallel, we will develop a data collection and data management system to support data collection and optimise data sharing with patients, clinicians and the research community. Our goal is to identify causal mechanisms by which sleep and circadian disruption leads to relapse in bipolar disorder. We will also deliver an innovative programme of knowledge exchange and dissemination in collaboration with Bipolar Scotland

We are seeking an enthusiastic and ambitious research fellow to join our research team to manage studies to develop novel methods for assessment of circadian rhythms. The successful candidate will work with us on cutting-edge research projects that focus on understanding how changes in the variability of circadian rhythms relate to human health and disease.

The research fellow will find ample opportunities to collaborate via our membership of circadian research collaborations in the UK, https://www.circadianmentalhealth.org/. They will be given support to develop their independent research career, including help with fellowship applications, building collaborations and research placements in other research groups.

This position is embedded in a collaboration across genetics, data science, chronobiology and psychiatry and the successful candidate will become a part of a large team of lived-experience advisors, patient advocates, PIs, postdocs, PhD students and research assistants working together to drive the field of chronopsychiatry forwards.

Salary

Research Fellow (2023): 61,318 63,096 p.a. pro-rata. (2 points with increment)

Appointments will be made in accordance with public sector pay provisions

Closing Date: 23:30hrs (local Irish time) on Sunday, 05th November 2023.

Please note all applications must be made via our Online Recruitment Portal at the following link: https://www.maynoothuniversity.ie/human-resources/vacancies

Please apply with your CV and a Cover letter that includes a brief summary of the following:

Applications must be submitted by the closing date and time specified above. Any applications which are still in progress at the closing time on the specified closing date will be cancelled automatically by the system.

Late applications will not be accepted.

Maynooth University is an equal opportunities employer

The position is subject to the Statutes of the University

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Research Fellow, Biology job with MAYNOOTH UNIVERSITY | 354742 - Times Higher Education

Lakebound but Unbroken: Jason Voorhees’ Biological Resilience … – The Rampage

Imagine the icy grip of Crystal Lake's water enveloping you as you wade deeper. The moonlight barely pierces the surface, casting eerie shadows on the lake bed. The air is thick with the scent of damp earth and decaying leaves. Your foot brushes against something unsettling below. You lock eyes with a hollow gaze behind a hockey mask. Your heart pounds. Welcome back to Fear By the Numbers, where we dissect the science behind your darkest fears. Today, we're diving into the enigmatic Jason Voorhees of the Friday the 13th franchise, exploring how this horror icon could theoretically survive underwater for extended periods in the depths of Crystal Lake.

Before becoming the embodiment of nightmares, Voorhees was a child with physical and mental impairments, shunned by society. Been thought to have drowned two decades prior, Voorhees emerges from the lake to exact his machete-wielding revenge upon his tormentors.His near-drowning at Camp Crystal Lake was a pivotal moment, setting the stage for his transformation into an unyielding force of terror.

Crystal Lake is no ordinary body of water. The lake's water is as murky as its history, a dark abyss that seems to swallow light itself like a living entity, silently aiding his transformations

Its unique ecosystem, characterized by low oxygen levels and high sediment concentration, is a breeding ground for extremophiles organisms that thrive in extreme conditions.

But what transpired during those submerged years? Could his physiology have adapted in ways that defy our understanding of human biology and could we all harbor a dormant monster within us? Can science explain the inexplicable?

The idea of rapid healing has always fascinated me. Given the unique conditions of Camp Crystal Lake, could Voorhees cells be mutating, evolving and becoming something not entirely human? Are human cells capable of that? In Biomolecular Action of Ionizing Radiation by Shirley Lehnert, she explains that ionizing radiation, commonly used during X-rays, can cause significant changes at the cellular level with extended exposure, affecting DNA structure and repair mechanisms.

Further, a study by Coralie Trentesaux and colleagues titled Essential role for autophagy protein ATG7 in the maintenance of intestinal stem cell integrity discusses DNA damage repair and survival under stress conditions. These ideas could explain how the distinct conditions of Camp Crystal Lake have influenced Voorhees' microbiota the community of microorganisms living inside him to adapt. This adaptation could enable him to survive with low levels of oxygen, much like certain deep-sea creatures. If he can survive with minimal oxygen, what's stopping him from lurking in your closet, silently waiting? It's a question that makes me double-check my locks at night.

Now, let's get into a probability model I've developed known as the "Voorhees Viability Index" to calculate the likelihood of human survival under extreme conditions. Utilizing Bayesian probability, which uses expectation or personal belief in calculating probabilities, the VVI takes into account the unique environmental factors of Crystal Lake. It also factors in human physiology, drawing from documented cases of extreme survival.

According to the VVI, the probability of a human adapting to such conditions is a staggering 0.0001%. To put this in perspective, using this model, the odds of being struck by lightning are 0.0002%. While these numbers may seem minuscule, they are not zero. In the realm of theoretical biology, that's enough to keep me and hopefully you wondering.

Jason Voorhees is not a static character; he's an evolving entity. From a vengeful son to an almost supernatural force, his character arc could be a reflection of his biological evolution. Each resurrection might not just bring him back but make him stronger, more resilient, and more adapted to extreme conditions.

As we dissect the biological possibilities behind Jason Voorhees, we're reminded that science can be as fascinating as it is unsettling. The line between scientific curiosity and morbid fascination blurs, leaving us with questions that might be better left unanswered. While we may never fully decode the mystery of his survival, one thing is clear: the next time you find yourself near Crystal Lake, you'll think twice before venturing into its depths. And even then, will you ever be truly alone? What if the science we trust to explain the world around us is the very thing that unlocks doors best left sealed, inviting nightmares into our reality that we can never escape?

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Lakebound but Unbroken: Jason Voorhees' Biological Resilience ... - The Rampage