Falcons film review, Week 1: Anatomy of a collapse against the Saints – The Falcoholic

Fellow Falcoholics, welcome to another new show here on The Falcoholic Podcast: the Falcons Film Review! Ill be bringing you an in-depth film breakdown each and every week from the previous game. Unfortunately this first review is going to be a negative one, as I decipher what exactly went wrong in the fourth quarter for the Atlanta Falcons against the New Orleans Saints. While there were plenty of good things shown by the team up until that point, another massive blown lead overshadowed it all.

Listen to the show in an audio-only podcast format, available on all your favorite podcast platforms or by using the player below.

You can also watch the recorded video version of the stream on our YouTube channel. Since there were NFL game clips in this video, you have to watch it directly on YouTube.

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Be sure to check out the new community Discord server here! Come chat with your fellow Falcons fans about the show, the team, the NFL draft, and more.

You can watch the show here on The Falcoholic, but we recommend watching on YouTube for the best experienceincluding full 1080p HD video and access to the live Q&A in the chat. You can also access the show using your smart TV or device using the YouTube app for the real big-screen experience!

We hope you enjoy the show! If you have comments, wed love to hear them. Send them to us on Twitter (@FalcoholicLive), leave them below, or e-mail the show at falcoholiclive@gmail.com.

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Falcons film review, Week 1: Anatomy of a collapse against the Saints - The Falcoholic

Greys Anatomy star looks unrecognisable as he shows off new blonde hair transformation can you tell who… – The US Sun

ONE of Grey's Anatomy biggest star's today looked unrecognisable as he showed off his new blonde hair transformation.

Fans were left shocked when Patrick Dempsey revealed his striking new locks.

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Known by fans as 'Doctor McDreamy', the actor played Derek Shepherd on Grey's Anatomy for 16 years until 2021.

But this weekend he showed off his new look while appearing at Disney's D23 Expo in California.

Instead of his signature salt-and-pepper coif, the hunky star debuted a shock of bleach blond hair.

While Patrick might be best known for his work on ABC's hit medical drama Grey's Anatomy, he's also reprising his role from a beloved Disney film.

Patrick will take to the screen alongside Amy Adams as their popular characters from Disney's Enchanted in the film's sequel, Disenchanted.

The first trailer for the film, set for release in November on Disney+, was revealed during D23 Expo.

Disenchanted will follow Giselle (Amy), the animated princess who fell in love in New York City in the first movie, as she and Robert (Patrick) move to the suburbs.

James Marsden and Idina Menzel are also reprising their roles for the fantasy film.

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"To work with everybody again after 14 years is just really exciting," Patrick toldVarietyin April 2021.

"We need some escapism right now. We need those romantic comedies and those musicals to get people out of the doldrums that we're in."

Before finding fame on Grey's Anatomy, Patrick had early success on the big screen starring in a number of 80s films including Can't Buy Me Love (1987), and Loverboy (1989).

In 2002 he also had the lead role alongside Reese Witherspoon in Sweet Home Alabama, which was a surprise box office hit.

Patrick is married to wife Jillian Fink, and the couple share three children.

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Greys Anatomy star looks unrecognisable as he shows off new blonde hair transformation can you tell who... - The US Sun

Hearts condemn ‘senseless behaviour’ following silence disruption – anatomy of a historic night at Tynecastle – The Scotsman

The players had left the field in the dying embers of a second Elizabethan age. When they re-emerged 15 minutes later, they were stepping out into a new age literally.

The Queen was dead. An announcement confirmed this at 6.30pm. King Charles III was now the reigning monarch. This smooth transition of the crown contrasted with how things played out on a dismal night in Gorgie.

The Tynecastle club were immaculate in their own efforts to comply with protocol for such an unusual occurrence as a reigning monarchs death being confirmed midway through a European fixture. The European element is significant. It meant Uefa were charged with putting into place an emergency procedure. It was a football version of London Bridge Is Down.

Enough black armbands for both teams were located. A decision to switch off the adverts flashing around the perimeter of the pitch was successfully implemented. News of the Queens death was relayed by announcer Graeme Easton at the start of the second half. The information was already spreading round the ground via social media. Generic instrumental music was played at a notably lower volume.

No birthday greetings were read out and neither was there any information about the clubs next game. It was already looking likely that tomorrows clash with St Mirren would be postponed, along with all other Scottish professional football matches this weekend.

In football terms, perhaps in other ways as well, Hearts might prefer to draw a veil over the European tie as quickly as possible - it was a good night to bury bad news like a 4-0 home defeat. And yet it will go down in history.

A recurring question in the years ahead will be, where were you when you heard Queen Elizabeth II had died? Around 15,000 or so will be able to say they were gathered at a stadium three or so miles from the official residence of the monarchy in Scotland. It was the only game of senior football on in Britain when the news was confirmed.

Heart of Midlothian are one of Scotlands most historic clubs. A team fought andnearly all died for King and country after conscripting en masse in 1915. Hearts played a Scottish Cup tie three days after the late Queens father, George IV, passed away on 6 February 1952. A 47,152 crowd observed a two-minute silence before Raith Rovers were beaten 1-0 with a late Willie Bauld goal.

Hearts greatest era in the mid-to-late 1950s might seem like a long time ago. But it still took place within the late Queens reign, which also covered Dave Mackays debut for Hearts in 1953 and Alex Youngs debut two years later. Ten of the clubs 16 major honours were won with her as Queen.

Its hard to analyse Thursday nights match without acknowledging the context. Footballers are professionals but Hearts were undeniably poorer in the second half.

Even the Turkish visitors, whose fate was landing amid a shifting of monarchical plates in Britain, wore black armbands. Turkey abolished their monarchy 100 years ago. Even my grandparents wouldnt have remembered a past full of sultans, London-based Turkish journalist Alp Ulagay later told me.

Nevertheless, Basaksehir were comfortable about taking part in the mourning. Manager Emre Belozoglu was careful to send his best wishes to the people of Great Britain afterwards.

The home players were banned from speaking to the media. Hearts manager Robbie Neilson answered only two questions. It meant avoiding dwelling on the disruption to the minutes silence that Uefa had instructed should take place at the start of the second half.

Again, this was unprecedented. Has there ever been a minutes silence at the start of a second half in British football before? When will there be one again? Likely never. Maybe thats a good thing.

Nobody was quite sure what was happening. Substitutes arrived late, skipper Craig Gordon, unsure when the minute was meant to have started, turned away too early. There was disunity, and worse, in the crowd too.

A shout of F*ck the Queen! from the Wheatfield Stand seconds in caused a rumble of commotion that included boos when a section of the main stand began singing God Save the Queen. Polish referee Krzysztof Jakubik cut things short.

Hearts issued a statement condemning the actions of the minority of supporters who took it upon themselves not to respect last nights minutes silence. It added: The club apologises, on their behalf, to those offended by their senseless behaviour during the time of national mourning, and we hope that lessons will be learned ahead of future tributes at Tynecastle Park.

Such a regrettable episode has prompted introspection and possibly some confusion among fans. Mike Hamilton, from Edinburgh, was drinking in the Golden Rule with his brother, Ken, afterwards. There are factions within the support, he said. These factions dont deeply divide people, they are surface level. People just have different views.

I was in Zurich watching Hearts last month and this sort of thing came up. There were fans with Union Jacks. Are Hearts a Scottish club or a British club? There are people with very different views on it, but they are still able to share a beer with each other.

The atmosphere was not typical of a European night at Tynecastle in the first place. It got notably more subdued. Hamilton puts this solely down to another poor performance from the hosts. The fans were flat because we were losing, he said. If Hearts were winning, it would have been different.

As it was, we got humbled 4-0 by a very good team. We reacted as we would have done two weeks or even two years ago. Perhaps. But little else felt normal.

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Hearts condemn 'senseless behaviour' following silence disruption - anatomy of a historic night at Tynecastle - The Scotsman

Gastrointestinal Physiology and Function – PubMed

The gastrointestinal (GI) system is responsible for the digestion and absorption of ingested food and liquids. Due to the complexity of the GI tract and the substantial volume of material that could be covered under the scope of GI physiology, this chapter briefly reviews the overall function of the GI tract, and discusses the major factors affecting GI physiology and function, including the intestinal microbiota, chronic stress, inflammation, and aging with a focus on the neural regulation of the GI tract and an emphasis on basic brain-gut interactions that serve to modulate the GI tract. GI diseases refer to diseases of the esophagus, stomach, small intestine, colon, and rectum. The major symptoms of common GI disorders include recurrent abdominal pain and bloating, heartburn, indigestion/dyspepsia, nausea and vomiting, diarrhea, and constipation. GI disorders rank among the most prevalent disorders, with the most common including esophageal and swallowing disorders, gastric and peptic ulcer disease, gastroparesis or delayed gastric emptying, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD). Many GI disorders are difficult to diagnose and their symptoms are not effectively managed. Thus, basic research is required to drive the development of novel therapeutics which are urgently needed. One approach is to enhance our understanding of gut physiology and pathophysiology especially as it relates to gut-brain communications since they have clinical relevance to a number of GI complaints and represent a therapeutic target for the treatment of conditions including inflammatory diseases of the GI tract such as IBD and functional gut disorders such as IBS.

Keywords: Absorption; Barrier function; Central nervous system (CNS); Colon; Constipation; Diarrhea; Digestion; Enteric nervous system (ENS); Epithelial barrier; Gut microbiome; Inflammation; Inflammatory bowel disease (IBD); Intestinal permeability; Irritable bowel syndrome (IBS); Mucosa; Secretion; Small intestine; Smooth muscle; Stress; Visceral pain.

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Gastrointestinal Physiology and Function - PubMed

Scientists find the best way to soothe a crying baby – Earth.com

The sound of a crying infant can be very distressing to parents. They seek to soothe the baby and may resort to numerous ploys in order to restore the baby to a state of peace. None of these methods has been scientifically proven, however, relying rather on trial and error or on the advice of experienced caregivers. In a new study by Japanese researchers, four different soothing methods were tested and the efficacy of each was assessed based on changes in the babys heart rate and whether the baby stopped crying.

Many parents suffer from babies nighttime crying, says corresponding author Kumi Kuroda of the RIKEN Center for Brain Science in Japan. Thats such a big issue, especially for inexperienced parents, that it can lead to parental stress and even to infant maltreatment in a small number of cases, she says.

The study details how crying babies are physiologically affected by being held, carried, and laid down. The researchers made use of ECG data on heart rate, and hand-held video cameras, to track the physiological and behavioral state of the baby as it was soothed. Mothers were given four methods for calming the baby: hold the crying infant, hold and walk with the infant, place the infant in a cot or crib, and place the infant in a mobile crib or stroller that can be moved back and forth. At each heartbeat, behavior was assessed as asleep, alert, or crying, and scored accordingly. This way the researchers could track changes in both behavior and physiology with sub-second precision.

In previous research, Kuroda and her colleagues found that mother mice pick up their babies (pups) by mouth and carry them when they are distressed. The mouse pups show a specific response, termed the Transport Response, when picked up by their mothers. This involves a complex series of parallel biological processes that results in reduced crying and lower heart rates, which helps the parents to transport the infants. Kruoda and the team wondered whether human infants would show similar physiological responses to being carried around, and whether this would have a calming impact when the infant was distressed.

The Transport Response is found in many mammals that have altricial young (born underdeveloped and helpless) that are not able to walk around on their own. Such mammals include dogs, cats and monkeys. We are more familiar with this response when picking up young puppies or kittens by the scruff of the neck. They tend to hang motionless and become more docile, but their bodies do not go entirely limp; they maintain a certain compactness of posture, with legs pulled in slightly, perhaps making it easier for their parents to carry them to a new location.

The researchers compared the responses of 21 human infants to soothing using the four different methods. They found that when the mother walked while carrying the baby, the crying infants calmed down and their heart rates slowed within 30 seconds. In fact, when mothers walked in this way for a period of five minutes, the infants became so calm that around 50 percent of them fell asleep. A similar calming effect occurred when the infants were placed in a rocking cot, but not when the mother held the baby while sitting, or placed the baby in a motionless cot.

As Kuroda explains, walking for five minutes promoted sleep, but only for crying infants. Surprisingly, this effect was absent when babies were already calm beforehand. Among the babies studied, all had stopped crying by the end of the five-minute walk and had reduced heart rates. However, sitting and holding a crying baby was not calming; the heart rate tended to increase and crying persisted. Heart rates also increased when walking mothers turned, or when they stopped walking, showing that babies are very sensitive to their mothers movements.

Unfortunately, the study found that when the mothers tried to put down their sleeping babies after calming them, more than one-third of the infants became alert again within 20 seconds. Analysis of the data showed that all the babies produced physiological responses, including changes in heart rate, the moment they became detached from the mothers body. However, if the infants were asleep for a longer period before being laid down, they were less likely to awaken during the process, the team found.

Even as a mother of four, I was very surprised to see the result. I thought whether a baby awoke during a laydown was related to how theyre put on the bed, such as their posture, or the gentleness of the movement, Kuroda says. But our experiment did not support these general assumptions. Although we did not predict it, the key parameter for successful laydown of sleeping infants was the latency from sleep onset. Babies often woke up if they were put down before they got about 8 minutes of sleep.

Based on their findings, the researchers propose a method for soothing and promoting sleep in crying infants. They recommend that parents hold crying infants and walk with them for five minutes, followed by sitting and holding infants for another five to eight minutes before putting them to bed. The protocol, unlike other popular sleep training approaches such as letting infants cry until they fall asleep themselves, aims to provide an immediate solution for infant crying. Whether it can improve infant sleep in the long-term requires further research, Kuroda says.

Although the research involved only mothers and their infants, Kuroda expects the effects are likely to be similar for fathers and any other caregivers. She emphasizes that this study only included a small samples of infants and will need to be repeated with bigger sample sizes in order to verify the results. Additionally, this procedure does not address why some babies cry excessively and cannot sleep, but it does offer an immediate solution that can help parents of newborns.

The researchers recognize the usefulness of heartrate data in this approach to soothing a baby and hope to make it accessible to parents. We are developing a baby-tech wearable device with which parents can see the physiological states of their babies on their smartphones in real-time, says Kuroda. Like science-based fitness training, we can do science-based parenting with these advances, and hopefully help babies to sleep and reduce parental stress caused by excessive infant crying.

The research is published in the journal Current Biology.

By Alison Bosman, Earth.com Staff Writer

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Scientists find the best way to soothe a crying baby - Earth.com

Revealing the Hidden Genome: Unknown DNA Sequences Identified That May Be Critical to Human Health – SciTechDaily

Scientists have developed a new technique to reveal the hidden human genome.

Numerous short RNA sequences that code for microproteins and peptides have been identified, providing new opportunities for the study of diseases and the development of drugs.

Researchers from Duke-NUS Medical School and their collaborators have discovered thousands of previously unknown DNA sequences in the human genome that code for microproteins and peptides that could be critical for human health and disease.

Much of what we understand about the known two per cent of the genome that codes for proteins comes from looking for long strands of protein-coding nucleotide sequences, or long open reading frames, explained computational biologist Dr Sonia Chothani, a research fellow with Duke-NUS Cardiovascular and Metabolic Disorders (CVMD) Programme and first author of the study. Recently, however, scientists have discovered small open reading frames (smORFs) that can also be translated from RNA into small peptides, which have roles in DNA repair, muscle formation and genetic regulation.

Scientists have been seeking to identify smORFs and the tiny peptides they code for since smORF disruption can cause disease. However, the currently available techniques are quite limited.

Much of the current datasets do not provide information that is detailed enough to identify smORFs in RNA, added Dr Chothani. The majority also comes from analyses of immortalised human cells that are propagatedsometimes for decadesto study cell physiology, function and disease. However, these cell lines arent always accurate representations of human physiology.

Chothani and her colleagues from Singapore, Germany, the United Kingdom, and Australia present an approach they created to address these challenges in a recentstudy published in Molecular Cell. They scoured existing ribosome profiling datasets for short strands of RNA with periodic three-base sections that covered more than 60% of the RNAs length. They then performed their own RNA sequencing and Ribosome profiling to establish a combined data set of six kinds of cells and five types of tissue derived from hundreds of patients.

Analyses of these data identified nearly 8,000 smORFs. Interestingly, they were highly specific to the tissues that they were found in, meaning that these smORFs may perform a function specific to their environment. The team also identified 603 microproteins coded by some of these smORFs.

The genome is littered with smORFs, said Assistant Professor Owen Rackham, senior author of the study from the CVMD Programme. Our comprehensive and spatially resolved map of human smORFs highlights overlooked functional components of the genome, pinpoints new players in health and disease and provides a resource for the scientific community as a platform to accelerate discoveries.

Professor Patrick Casey, Senior Vice-Dean of Research at Duke-NUS, said, With the healthcare system evolving to not only treat diseases but also prevent them, identifying potential new targets for disease research and drug development could open avenues to new solutions. This research by Dr Chothani and her team, published as a resource for the scientific community, brings important insights to the field.

Reference: A high-resolution map of human RNA translation by Sonia P. Chothani, Eleonora Adami, Anissa A. Widjaja, Sarah R. Langley, Sivakumar Viswanathan, Chee Jian Pua, Nevin Tham Zhihao, Nathan Harmston, Giuseppe DAgostino, Nicola Whiffin, Wang Mao, John F. Ouyang, Wei Wen Lim, Shiqi Lim, Cheryl Q.E. Lee, Alexandra Grubman, Joseph Chen, J.P. Kovalik, Karl Tryggvason, Jose M. Polo, Lena Ho, Stuart A. Cook, Owen J.L. Rackham and Sebastian Schafer, 15 July 2022, Molecular Cell.DOI: 10.1016/j.molcel.2022.06.023

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Revealing the Hidden Genome: Unknown DNA Sequences Identified That May Be Critical to Human Health - SciTechDaily

EHS Patients: SOFA Score Usefulness on Admission to Predict the 90-day Mortality – Physician’s Weekly

Exertional heat stroke (EHS) is becoming more understood, yet there is a lack of clinical data to support risk-stratifying EHS patients. Finding a suitable scoring system for EHS prognostic evaluation was researchers main goal for a study.

All EHS patients hospitalized in the intensive care unit (ICU) of the General Hospital of Southern Theatre Command of the PLA between October 2008 and May 2019 were included in the retrospective cohort analysis. Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA), Glasgow Coma Scale (GCS) scores, inflammatory indices, and organ function measurements were all gathered at the time of admission. With the use of a multivariate Cox proportional hazard risk regression model, risk variables for 90-day mortality were found.

Finally, 189 patients (all male) were included; 21 years (IQR 19.027.0), their median APACHE II score was 11.0 (IQR 8.016.0), their median SOFA score was 3.0 (IQR 2.06.0), and their median GCS score was 12.0 (IQR 7.014.0). There were 23 non-survivors (12.2%) compared to 166 survivors (87.8%). Rhabdomyolysis (46.1% vs. 63.6%), disseminated intravascular coagulation (25.6% vs. 90.0%), acute liver injury (69.4% vs. 95.7%), and acute kidney injury (36.6% vs. 95.7%) were among the serious organ injuries that were more common in non-survivors than in the survivor group. A multivariate Cox risk regression model with an ideal cutoff score of 7.5 revealed that the SOFA score was an independent risk factor for 90-day death.

A clinically relevant predictor of mortality in EHS may be the SOFA score. The best cutoff level and the usefulness of the SOFA score must be confirmed by prospective research.

Reference: sciencedirect.com/science/article/abs/pii/S0735675722005447

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EHS Patients: SOFA Score Usefulness on Admission to Predict the 90-day Mortality - Physician's Weekly

Rewarding Geophysical Research | The UCSB Current – The UCSB Current

In recognition of their meritorious work and service toward the advancement and promotion of discovery and solution science, three faculty from UC Santa Barbara have been selected for section awards from the American Geophysical Union (AGU).

Debra Perrone, Samantha Stevenson and Anna Trugman are being recognized for their early career achievements by AGU, a nonprofit organization that supports 130,000 experts and enthusiasts worldwide in Earth and space sciences. The union annually recognizes a number of individuals as part of its Honors and Recognition program.

Debra Perrone was chosen for a Hydrologic Sciences Early Career Award, which recognizes outstanding contributions to hydrology through research, education, or societal impacts.

I am grateful for the support of my colleagues who nominated me for this award, as well as the hydrologic sciences community, more broadly, for their support of research that integrates multiple disciplines and has a focus on societal impacts, said Perrone, an assistant professor in the Environmental Studies Program.

Perrone focuses on identifying and solving societys water-scarcity challenges, particularly issues concerning groundwater. She takes a broad approach to the task, combining research methods from engineering, physical science and law to inform water sustainability and policy.

AGU conferred an Ocean Sciences Early Career Award to Samantha Stevenson, an assistant professor in the Bren School of Environmental Science & Management. The award lauds significant contributions to the ocean sciences from honorees within 10 years of receiving their Ph.D.

As a physical oceanographer, Stevenson studies the physical mechanisms that affect movement of water in the ocean. Shes particularly interested in understanding how interactions between the ocean and atmosphere alter the behavior of El Nio and La Nia events.

Stevenson uses numerical ocean and climate models to investigate how those processes respond to climate change. Some of her work focuses on projections of future 21st century climate change. Shes also considering how to use reconstructions of climatic conditions over the past several hundred years to improve both our knowledge of the past and our estimates of what we may expect in the future.

It has been my dream for a long time to contribute to humanity's knowledge of the oceans in order to help us prepare for the ongoing threat of climate change, Stevenson said. I am tremendously excited that my work has been recognized by the AGU Ocean Sciences section.

I plan to continue doing my best to solve important ocean and climate problems, she added, and also hope this award will help me be a good role model for the younger generation of women in physical oceanography.

Anna Trugman received a Global Environmental Change Early Career Award. The honor cites researchers whove made outstanding contributions in research, educational, or societal impacts in the area of global environmental change [] within 10 years of receiving their Ph.D. or highest terminal degree.

I'm extremely excited to be among Debra and Sam as early career female environmental scientists winning these awards, said Trugman, an assistant professor in the Department of Geography.

Trugman is a plant ecologist interested in the terrestrial carbon cycle. Her lab focuses on how climate change impacts forest resilience as well as carbon, water and energy fluxes from the land surface to the broader Earth system.

Some of her current projects include the ecological, carbon-cycle and economic consequences of wildfire in California. She also aims to understand how the physiology of plants under stress shapes ecosystem resilience and biogeographic patterns in water-limited systems.

AGU will formally recognize this years recipients during the AGU22 Fall Meeting, which convenes Dec. 1216 in Chicago, and online. This celebration is a chance for the unions community to recognize the outstanding work of their colleagues and be inspired by their accomplishments and stories.

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Expert in Engineered Cell-Based Cancer Therapies Appointed USC Viterbi BME Chair – USC Viterbi School of Engineering

New Chair of the USC Viterbi Department of Biomedical Engineering.Peter Yingxiao Wang. Image/David Baillot, UC San Diego Jacobs School of Engineering.

Research leader in the field of precision medicine, Professor Peter Yingxiao Wang, will join the USC Viterbi School of Engineering on January 1, 2023, as the new chair of the Department of Biomedical Engineering.

Wang who has pioneered work on controllable engineered cells to directly target tumors will also be jointly appointed at the Keck School of Medicine of USC. He will lead two research laboratories to be housed in the USC Michelson Center for Convergent Bioscience on the UPC campus and the USC Norris Comprehensive Cancer Center on the USC Health Sciences Campus.

Wang comes to USC Viterbi after ten years as a faculty member at the University of California San Diego, where as professor of bioengineering he pursued leading research into cancer immunotherapy and cell imaging. Most recently, Wang and his collaborators developed a breakthrough therapy harnessing focused ultrasound (FUS) to remotely-control specially engineered immune cells, known as FUS-CAR T-cells, to target and destroy solid tumors with high precision in space and time, while avoiding side effects and toxicity on healthy tissue.

Wangs role will further fortify USC Viterbis research capacity in precision medicine, while forging stronger collaborations with Keck School of Medicine.

I am thrilled that Peter has decided to join us as the new chair of Biomedical Engineering at USC, said USC Viterbi Dean Yannis C. Yortsos. He will lead a remarkable department the first biomedical engineering department on the West Coast with a history of landmark accomplishments in this critical field, at the intersection of engineering, medicine and the health sciences. We look forward to his leadership and vision.

Wang said he was excited to join the department, noting that USC was positioned at a unique advantage, thanks to the depth of research and teaching excellence in both its engineering and medical schools.

We already have a very strong Department of Biomedical Engineering with multiple rising stars who were recently promoted, combined with the existing strengths from senior faculty, and of course our fabulous students, Wang said. We are really strong in both engineering and medicine, and one thing I would like to push is for more intimate and systematic collaboration between USC Viterbi and Keck School, as well as the Childrens Hospital Los Angeles.

Its a really exciting trend for our departments future, giving us the opportunity to bring our cutting-edge technology directly to patients, where we can really help people.

Wang said that through increased collaboration, he was eager to break down silos and shorten the pipeline from research and discovery toward patient applications of therapies and technologies. He said he was also interested in ensuring the BME department further expanded its considerable strengths in precision medicine.

We have talented faculty working in this area already, like Associate Professor Stacey Finley who works on analysis of immune cell signaling, Associate Professor Megan McCain who is working on stem cell and tissue engineering, Associate Professor Eun Ji Chung, who is looking at how we can deliver the genetic and therapeutic materials more efficiently to different locations in the body, and Associate Professor Keyue Shen who is working on immune-engineering approaches, Wang said. This is in addition to our superior senior faculty, like Professors David DArgenio, Michael Khoo, Vasilis Marmarelis, Francisco Valero-Cuevas, and Ellis Meng on biomedical modeling, machine learning, neuromuscular control and medical devices, and Professors Qifa Zhou and Jesse Yen, who are leaders in ultrasound technology.

We also have a promising and strong group of junior faculty, like Assistant Professors Cristina Zavaleta on molecular imaging, Jennifer Treweek on quantitative histopathology, and Maral Mousavi on biomedical sensors and diagnosis. Together with other leading professors in the department, like Ted Berger, Gerald Leob, Bartlett Mel and Stan Yamashiro, it will offer more opportunity to collaborate, to sharpen our expertise and to make our ultrasound-controllable CAR-T cell system even more powerful and precise, Wang said.

Wang obtained his bachelors and masters degrees from Peking University, Beijing in 1992 and 1996, in mechanics and in fluid mechanics, respectively. He moved to California where he received his Ph.D. degree in Bioengineering from the UCSD Jacobs School of Engineering in 2002, before continuing his postdoctoral work there under Bioengineering Professor Shu Chien and Professor Roger Y. Tsien in the Department of Pharmacology.

Before joining the UCSD as faculty in 2012, he was an associate professor at the University of Illinois, Urbana-Champaign (UIUC) Department of Bioengineering, and a full-time faculty member in the Beckman Institute for Advanced Science and Technology at the University of Illinois. He was also affiliated at UIUC with the Department of Molecular and Integrative Physiology, Neuroscience Program, the Center for Biophysics and Computational Biology, and Institute of Genomic Biology.

Wang is a recipient of the competitive Wallace H. Coulter Early Career Award and was also awarded the National Science Foundation CAREER Award, and the National Institutes of Health Independent Scientist Award.

He is a fellow of the American Institute of Medical and Biological Engineering (AIMBE), the International Academy of Medical and Biological Engineering (IAMBE), and the Biomedical Engineering Society (BMES).

Wang will take over the chairs role from Interim Department Chairs David Z. DArgenio, Michael Khoo and Vasilis Marmaralis, who will continue to serve in that capacity until January 2023.

Published on September 16th, 2022

Last updated on September 16th, 2022

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Expert in Engineered Cell-Based Cancer Therapies Appointed USC Viterbi BME Chair - USC Viterbi School of Engineering

Modeling the social mind | MIT News | Massachusetts Institute of Technology – MIT News

Typically, it would take two graduate students to do the research that Setayesh Radkani is doing.

Driven by an insatiable curiosity about the human mind, she is working on two PhD thesis projects in two different cognitive neuroscience labs at MIT. For one, she is studying punishment as a social tool to influence others. For the other, she is uncovering the neural processes underlying social learning that is, learning from others. By piecing together these two research programs, Radkani is hoping to gain a better understanding of the mechanisms underpinning social influence in the mind and brain.

Radkani lived in Iran for most of her life, growing up alongside her younger brother in Tehran. The two spent a lot of time together and have long been each others best friends. Her father is a civil engineer, and her mother is a midwife. Her parents always encouraged her to explore new things and follow her own path, even if it wasnt quite what they imagined for her. And her uncle helped cultivate her sense of curiosity, teaching her to always ask why as a way to understand how the world works.

Growing up, Radkani most loved learning about human psychology and using math to model the world around her. But she thought it was impossible to combine her two interests. Prioritizing math, she pursued a bachelors degree in electrical engineering at the Sharif University of Technology in Iran.

Then, late in her undergraduate studies, Radkani took a psychology course and discovered the field of cognitive neuroscience, in which scientists mathematically model the human mind and brain. She also spent a summer working in a computational neuroscience lab at the Swiss Federal Institute of Technology in Lausanne. Seeing a way to combine her interests, she decided to pivot and pursue the subject in graduate school.

An experience leading a project in her engineering ethics course during her final year of undergrad further helped her discover some of the questions that would eventually form the basis of her PhD. The project investigated why some students cheat and how to change this.

Through this project I learned how complicated it is to understand the reasons that people engage in immoral behavior, and even more complicated than that is how to devise policies and react in these situations in order to change peoples attitudes, Radkani says. It was this experience that made me realize that Im interested in studying the human social and moral mind.

She began looking into social cognitive neuroscience research and stumbled upon a relevant TED talk by Rebecca Saxe, the John W. Jarve Professor in Brain and Cognitive Sciences at MIT, who would eventually become one of Radkanis research advisors. Radkani knew immediately that she wanted to work with Saxe. But she needed to first get into the BCS PhD program at MIT, a challenging obstacle given her minimal background in the field.

After two application cycles and a years worth of graduate courses in cognitive neuroscience, Radkani was accepted into the program. But to come to MIT, she had to leave her family behind. Coming from Iran, Radkani has a single-entry visa, making it difficult for her to travel outside the U.S. She hasnt been able to visit her family since starting her PhD and wont be able to until at least after she graduates. Her visa also limits her research contributions, restricting her from attending conferences outside the U.S. That is definitely a huge burden on my education and on my mental health, she says.

Still, Radkani is grateful to be at MIT, indulging her curiosity in the human social mind. And shes thankful for her supportive family, who she calls over FaceTime every day.

Modeling how people think about punishment

In Saxes lab, Radkani is researching how people approach and react to punishment, through behavioral studies and neuroimaging. By synthesizing these findings, shes developing a computational model of the mind that characterizes how people make decisions in situations involving punishment, such as when a parent disciplines a child, when someone punishes their romantic partner, or when the criminal justice system sentences a defendant. With this model, Radkani says she hopes to better understand when and why punishment works in changing behavior and influencing beliefs about right and wrong, and why sometimes it fails.

Punishment isnt a new research topic in cognitive neuroscience, Radkani says, but in previous studies, scientists have often only focused on peoples behavior in punitive situations and havent considered the thought processes that underlie those behaviors. Characterizing these thought processes, though, is key to understanding whether punishment in a situation can be effective in changing peoples attitudes.

People bring their prior beliefs into a punitive situation. Apart from moral beliefs about the appropriateness of different behaviors, you have beliefs about the characteristics of the people involved, and you have theories about their intentions and motivations, Radkani says. All those come together to determine what you do or how you are influenced by punishment, given the circumstances. Punishers decide a suitable punishment based on their interpretation of the situation, in light of their beliefs. Targets of punishment then decide whether theyll change their attitude as a result of the punishment, depending on their own beliefs. Even outside observers make decisions, choosing whether to keep or change their moral beliefs based on what they see.

To capture these decision-making processes, Radkani is developing a computational model of the mind for punitive situations. The model mathematically represents peoples beliefs and how they interact with certain features of the situation to shape their decisions. The model then predicts a punishers decisions, and how punishment will influence the target and observers. Through this model, Radkani will provide a foundational understanding of how people think in various punitive situations.

Researching the neural mechanisms of social learning

In parallel, working in the lab of Professor Mehrdad Jazayeri, Radkani is studying social learning, uncovering its underlying neural processes. Through social learning, people learn from other peoples experiences and decisions, and incorporate this socially acquired knowledge into their own decisions or beliefs.

Humans are extraordinary in their social learning abilities, however our primary form of learning, shared by all other animals, is learning from self-experience. To investigate how learning from others is similar to or different from learning from our own experiences, Radkani has designed a two-player video game that involves both types of learning. During the game, she and her collaborators in Jazayeris lab record neural activity in the brain. By analyzing these neural measurements, they plan to uncover the computations carried out by neural circuits during social learning, and compare those to learning from self-experience.

Radkani first became curious about this comparison as a way to understand why people sometimes draw contrasting conclusions from very similar situations. For example, if I get Covid from going to a restaurant, Ill blame the restaurant and say it was not clean, Radkani says. But if I hear the same thing happen to my friend, Ill say its because they were not careful. Radkani wanted to know the root causes of this mismatch in how other peoples experiences affect our beliefs and judgements differently from our own similar experiences, particularly because it can lead to errors that color the way that we judge other people, she says.

By combining her two research projects, Radkani hopes to better understand how social influence works, particularly in moral situations. From there, she has a slew of research questions that shes eager to investigate, including: How do people choose who to trust? And which types of people tend to be the most influential? As Radkanis research grows, so does her curiosity.

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Modeling the social mind | MIT News | Massachusetts Institute of Technology - MIT News