Abetment To Innovation To Drive The Growth Factors Market KSU | The Sentinel Newspaper – KSU | The Sentinel Newspaper

The forecast period will witness a shift of notion about healthcare from just being sick care to health and wellness. The Growth Factors Market entails the integration of this shift into the design of delivery locations/channels and service offerings by the key market participants. This could include at-home prescription delivery, virtual care, self-service application for behavior modification, and decision support.

According to the latest market report published by PMR on the growth factors market during 2014 2018 and forecast for 2019 2029, the global growth factors market is projected to reach ~ US$ 2.5 Bn by the end of 2029. The growth factors market is expected to grow with a CAGR of ~ 8 % during the forecast period 2019-2029.

Growth factors are gaining high demand for cell culture-based research in the field of oncology, wound management, cardiovascular, and other medical fields. The growth factors market is expected to grow at a significant rate due to the growing demand for stem cell biology research.

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Increasing Life Science Research Funding Favors the Growth of the Market

Growth factors & cytokines play an important role in life science-based research. Various government, private, and commercial organizations are providing funding for life science-based research for the development of new products to reduce illness and economic burden. Investments in R&D are likely to increase in countries such as China, India, and South Korea.

Moreover, the increasing demand for growth factors in tissue regeneration and regenerative medicines is also expected to propel the growth of the global growth factors market. The global growth factors market is expected to witness significant growth over the forecast period due to increasing oncological and stem cell biology research funding, and the development of new products for wound management.

However, the high cost of some growth factors and lack of skilled professionals are among the major factors hindering the growth of the growth factors market.

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Interleukins to Gain Significant Market Value Shares in the Global Growth Factors Market

Based on product type, the global growth factors market has been segmented into Interleukin (ILs), Epidermal Growth Factors (EGFs), Transforming Growth Beta Factor (TGF-beta), Fibroblast Growth Factors (FGFs), Insulin-Like Growth Factors (IGFs), Platelet-Derived Growth Factors (PDGFs), Hepatocyte Growth Factors (HGFs), Vascular Endothelial Growth Factors (VEGFs), Tumor Necrosis Factors (TNFs), and others.

In terms of revenue, the Interleukins (ILs) are expected to hold a prominent share in the growth factors market revenues, through the end of forecast period.

Based on application, the global growth factors market has been segmented into oncology, dermatology, cardiovascular disease & diabetes, hematology, wound healing, cell culture, and others. Cell culture will remain the most prominent application area of growth factors, as indicated by PMRs study. By end user, the global growth factors market continues to witness a strong boost through the growing demand from contract research organizations, pharmaceutical & biotechnology companies, and research centers & academic institutes.

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North America Holds a Prominent Revenue Share in the Global Growth Factors Market

Geographically, the global growth factors market has been segmented into East Asia, South Asia, Oceania, North America, Latin America, Europe, and the Middle East & Africa. North America holds a prominent revenue share in the global growth factors market as of 2018.

The East Asia growth factors market is expected to grow with a significant growth rate over the forecast period. Countries such as the U.S., China, Germany, Japan, the UK, France, and India accounted for a significant revenue share in the global growth factors market in 2018.

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Molecular Biologists Travel Back in Time Over 3 Billion Years – SciTechDaily

A research group working at Uppsala University has succeeded in studying translation factors important components of a cells protein synthesis machinery that are several billion years old. By studying these ancient resurrected factors, the researchers were able to establish that they had much broader specificities than their present-day, more specialized counterparts.

In order to survive and grow, all cells contain an in-house protein synthesis factory. This consists of ribosomes and associated translation factors that work together to ensure that the complex protein production process runs smoothly. While almost all components of the modern translational machinery are well known, until now scientists did not know how the process evolved.

The new study, published in the journal Molecular Biology and Evolution, took the research group led by Professor Suparna Sanyal of the Department of Cell and Molecular Biology on an epic journey back into the past. A previously published study used a special algorithm to predict DNA sequences of ancestors of an important translation factor called elongation factor thermo-unstable, or EF-Tu, going back billions of years. The Uppsala research group used these DNA sequences to resurrect the ancient bacterial EF-Tu proteins and then to study their properties.

The researchers looked at several nodes in the evolutionary history of EF-Tu. The oldest proteins they created were approximately 3.3 billion years old.

Suparna Sanyal is a Professor at the Department of Cell and Molecular Biology, Uppsala University. Credit: David Naylor

It was amazing to see that the ancestral EF-Tu proteins matched the geological temperatures prevailing on Earth in their corresponding time periods. It was much warmer 3 billion years ago and those proteins functioned well at 70C, while 300 million-year-old proteins were only able to withstand 50C, says Suparna Sanyal.

The researchers were able to demonstrate that the ancient elongation factors are compatible with various types of ribosome and therefore can be classified as generalists, whereas their modern descendants have evolved to fulfil specialist functions. While this makes them more efficient, they require specific ribosomes in order to function properly. The results also suggest that ribosomes probably evolved their RNA core before the other associated translation factors.

The fact that we now know how protein synthesis evolved up to this point makes it possible for us to model the future. If the translation machinery components have already evolved to such a level of specialization, what will happen in future, for example, in the case of new mutations? ponders Suparna Sanyal.

The fact that researchers have demonstrated that it is possible to recreate such ancient proteins, and that extremely old translation factors work well with many different types of ribosome, indicates that the process is of potential interest for protein pharmaceuticals research. If it turns out that other ancient components of protein synthesis were also generalists, it might be possible to use these ancient variants to produce therapeutic proteins in future with non-natural or synthetic components.

Reference: Kinetic Analysis Suggests Evolution of Ribosome Specificity in Modern Elongation Factor-Tus from Generalist Ancestors by Arindam De Tarafder, Narayan Prasad Parajuli, Soneya Majumdar, Betl Kaar and Suparna Sanyal, 19 April 2021, Molecular Biology and Evolution.DOI: 10.1093/molbev/msab114

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Molecular Biologists Travel Back in Time Over 3 Billion Years - SciTechDaily

VALUE study: a protocol for a qualitative semi-structured interview study of IVF add-ons use by patients, clinicians and embryologists in the UK and…

This article was originally published here

BMJ Open. 2021 May 21;11(5):e047307. doi: 10.1136/bmjopen-2020-047307.

ABSTRACT

INTRODUCTION: For couples undergoing assisted reproduction, a plethora of adjuncts are available; these are known as add-ons. Most add-ons are not supported by good quality randomised trial evidence of efficacy, with some proven to be ineffective. However, estimates suggest that over 70% of fertility clinics provide at least one add-on, often at extra cost to the patient. This study has three aims. First, to undertake a survey of in vitro fertilisation (IVF) clinics in the UK to ascertain which add-ons are being offered and at what cost. Second, to undertake qualitative semi-structured interviews of patients, clinicians and embryologists, to explore their opinions and beliefs surrounding add-ons. Third, to review the interpretation of the Human Fertilisation and Embryology Authority traffic light system, to better understand the information required by IVF patients, clinicians and embryologists when making decisions about add-ons.

METHODS AND ANALYSIS: All UK IVF clinics will be contacted by email and invited to complete an online survey. The survey will ask them which add-ons they offer, at what cost per cycle and how information is shared with patients. Semi-structured interviews will be conducted in the UK and Australia with three groups of participants: (i) fertility patients; (ii) clinicians and (iii) embryologists. Participants for the interviews will be recruited via social media channels, website adverts, email and snowball sampling. Up to 20 participants will be recruited for each group in each country. Following an online consent process, interviews will be conducted via video-conferencing software, transcribed verbatim and data subjected to inductive thematic analysis.

ETHICS AND DISSEMINATION: Ethical approval has been granted by the Universities of Sheffield, Bath Spa and Melbourne. Findings will be published in a peer-reviewed journal and disseminated to regulatory bodies in the UK and Australia. A lay summary of findings will be shared via Fertility Network, UK.

PMID:34020980 | DOI:10.1136/bmjopen-2020-047307

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VALUE study: a protocol for a qualitative semi-structured interview study of IVF add-ons use by patients, clinicians and embryologists in the UK and...

First Lady hands over 30 000 books – The Herald

The Herald

Tendai RupapaSenior ReporterFirst Lady Auxillia Mnangagwa yesterday handed over 30 000 books to the Ministry of Primary and Secondary Education in a gesture which demonstrates the importance of partnerships.

The books are a result of a strong working relationship between the First Lady and an international organisation, Merck Foundation, a partnership which has yielded a lot of positive results for the country.

Amai Mnangagwa is the ambassador of Merck More than a Mother in Zimbabwe.

The First Lady values childrens education and has always been providing learning materials in schools and paying fees for disadvantaged children countrywide.

The books she donated yesterday are Educating Rujeko, which tackles issues of child marriages, Tudus story which deals with issues of infertility and Make the right Choices which dwells on doing what is right in this era of Covid-19.

Speaking at the handover ceremony yesterday, the First Lady said a special relationship has grown over the past three years between Angel of Hope Foundation and Merck Foundation which share the same values and are seized with the welfare and well-being of the most vulnerable in society, mainly women and children.

Over the past few years we have come up with many ideas on how we can improve the welfare of our people. I am glad to say this partnership has yielded a lot of positive things for the country, she said.

Doctors, the First Lady said, have been trained in specialist areas of infertility and embryology, diabetes mellitus, oncology and respiratory medicine. More than 100 doctors have been trained either online or have gone to India for specialist training.

We have had media training in Zimbabwe. The importance of this is to have our media practitioners being able to write well-researched stories on sensitive health topics. For example, subjects on infertility which are considered taboo in our societies. They have a duty to inform the public with articles that have depth. Awards have also been given to journalists who have done very well, she said.

She emphasised that Merck Foundation has also worked with her foundation in responding to the Covid-19 pandemic.

I wish to particularly thank the CEO of Merck Foundation Senator Dr Rasha Kelej who is one of the most influential women in Africa for starting the Merck more than a Mother movement of which she is the president. This has brought issues of infertility to the forefront.

Merck Foundation is also working with other African First Ladies. It is with this in mind that Angel of Hope Foundation and Merck Foundation have developed some reading material on subjects which need awareness. Knowledge is power. We need our people to be knowledgeable on these critical issues. That way, we also contribute to his Excellencys call for Zimbabwe achieving an upper middle class economy by 2030, said the First Lady.

In is acceptance speech, Primary and Secondary Education Minister Cain Mathema praised the First Lady for her gesture.

The Ministry is aware of the spirit that you have towards the welfare of all Zimbabweans and the vulnerable members of our communities. It is a fact that you are doing a valuable task through the Angel of Hope Foundation.

The donation that we have received today is testimony of the good work that you are doing to all Zimbabweans. Your generous donation dovetails with the ministrys vision of providing equitable, quality, inclusive and relevant education, he said.

Minister Mathema said one of their major challenges since 2015 when they introduced their competency-based curriculum was the shortage of learning and teaching materials.

The titles of the books you have donated do not only demonstrate the need for quality education for the learners, but also point towards moulding our learners along the expected values as enshrined in our educational philosophy of Unhu/Ubuntu, he said.

In her vote of thanks, Secretary for Primary and Secondary Education Mrs Tumisang Thabela said it was a fact that education was anchored on reading and more time people spent reading, the more they consciously and subconsciously gained the skill they needed to deal with the complexities of various tasks.

Indeed, the books that you have donated Amai will not only enable learners to gain knowledge but enable them to acquire the much-needed skills and attitudes that are necessary for life. The ministry is therefore indebted to you for this good gesture.

The books will help the children to make the right choices in their lives. We will also look into uploading the soft copies on our website and make sure they are accessed by all children. Amai you are more than a mother to us, she said.

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First Lady hands over 30 000 books - The Herald

Real history behind Call the Midwife: What is the Abortion Act and when did it pass? – RadioTimes

Over the last few seasons, Call the Midwife has covered the topic of abortion across multiple storylines and always with great thoughtfulness and care.

Weve seen the effects of desperate self-induced abortions (or attempted abortions), with skewers and drugs; weve seen the backstreet abortions, carried out in unsanitary conditions with unclean instruments. And weve also seen the safer (but still illegal) option of abortion secretly carried out by doctors at private clinics.

Alongside that, we have followed the stories of so many desperate women who feel they have no other choice but to terminate their pregnancies whether that be because of poverty, or abuse, or because they are unmarried, or because they are just not ready to be mothers.

The first season of Call the Midwife was set in 1957. With each season of the show, a year has passed, and now in season 10 we have reached 1966. That puts us on the cusp of an important change in the law. Heres what you need to know:

The Abortion Act 1967 was signed into law on 27th October of that year, and came into effect six months later. From that point, abortion was legal in a wide range of cases everywhere in Great Britain, except Northern Ireland. This landmark legislation remains in place today (with some amendments).

Season 10 of Call the Midwife covers the whole of 1966, so weve just reached a point in history where the debate was ramping up and the process was beginning in Parliament. Season 11 will cover the year in which the Act actually passed.

As Nurse Trixie Franklin (Helen George) points out heatedly to Mr Scarisbrick (Richard Dillane) of the Lady Emily Clinic, abortion remained illegal in 1966, even if it was being debated in Parliament.

Historically, self-induced abortion or supplying the means for an abortion had been prohibited under the Offences Against the Person Act 1861. This was punishable by a maximum sentence of life imprisonment.

Another key piece of legislation was theInfant Life Preservation Act 1929. This created the offence of child destruction, but clarified that an abortion could be carried out inexceptional circumstances.

Those exceptional circumstances were clarified in 1938 when a 14-year-old girl was gang-raped, and became suicidal when she fell pregnant. Dr Alex Bourne challenged the law and performed an abortion because the mothers mental health was in danger. Following this precedent, some women were granted a safe abortion if a psychiatrist approved (and the woman could afford a psychiatrist).

Cath became ill after an illegal abortion in season eight (BBC)

There were several strands in the campaign for legal abortion.

For one thing, there was growing pressure for a law which eliminated dangerous back-street abortions, and put the procedure in the hands of doctors (who could carry the procedure out more safely). This was one of the initial aims of the Abortion Law Reform Association (ALRA), which became a powerful voice on the issue.

The doctors themselves also sought new legislation. The medical establishment wanted clear laws establishing whether they could terminate a pregnancy that threatened the life of the woman, or would result in grave injury to her health; as explained above, there were precedents that had been established over the years, but they needed more clarity to avoid getting into legal trouble. Campaigner and doctor DB Paintin wrote to the British Medical Journal in 1966: At present the law seems uncertain and threatening, and consequently is frequently interpreted narrowly.

Also, a report in the British Journal of Criminology from 1966 provides a snapshot of how quickly the issue of abortion rose to the top of the agenda, and how peoples feelings changed. Madeleine Simms wrote: The significant development since 1964 has been that this debate has reached the general public, and in consequence become a life political issue. Not so long ago, newspaper editors, broadcasters and television producers hesitated over abortion because of the scandalous and controversial nature of the subject. Now, more often, if they hesitate at all, it is because the subject has been over-exposed.

In spring 1965, a nationwide survey found that three-quarters of the public believed abortion ought to be legal, at least in some cases.

Vals grandma Elsie Dyer was revealed as an illegal abortionist (BBC)

Momentum was building for a change in the law, but the government would not introduce legislation themselves. Instead, it was left to an MP called David Steel to introduce the Act as a Private Members Bill.

This unusual set-up requires a brief explanation. Most of the time, it is the government which comes up with a bill and introduces it to Parliament. However, individual Members of Parliament can also propose legislation, and that is what Steel decided to do.

Very few Private Members Bills ever succeed, because they are given little time or priority. Previous attempts to change the abortion law this way had failed, including a bill introduced by Renee Short MP in June 1965 and Lord Silkins Abortion Bill of November 1965.

But Steels bill came just at the right moment; and even though Steel was from the Liberal Party, the Labour government gave his Private Members Bill their backing. Home Secretary Roy Jenkins ensured the bill was given enough time to allow a full debate.

In addition, the government appointed Sir John Peel (the president of the Royal College of Obstetricians and Gynaecologists) to chair a medical advisory committee. It reported in favour of passing the bill.

Members of Parliament were given a free vote on the Abortion Bill. After a spirited debate, it passed with only 29 MPs voting against.

Under the Abortion Act, two doctors are required acting in good faith, to certify that the abortion is legal when a pregnancy of less than 24 weeks threatens the physical or mental health of the woman and her children, taking into account her actual or foreseeable environment.

The limit was originally 28 weeks, but was reduced to 24 weeks in most cases under the Human Fertilisation and Embryology Act 1990 after advances in medical technology moved the goalposts for when a pregnancy could be considered viable.

Additional reporting: Anna Barry

Call the Midwife continues on Sundays at 8pm on BBC One. Take a look at the rest of our Drama coverage, or check out our TV guide to find out what else is on.

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Real history behind Call the Midwife: What is the Abortion Act and when did it pass? - RadioTimes

The Lawmakers Behind Fetal Heartbeat Abortion Bans Are Lying To You – HuffPost

Its been two years since conservative lawmakers began widely using fetal heartbeat rhetoric to pass bans on abortion as early as six weeks into pregnancy.

But despite the medical community speaking out against the inaccurate language and dozens of lawsuits stopping those laws from going into effect, those bills havent slowed down. The latest comes from Texas, where Gov. Greg Abbott (R) signed a bill Wednesday effectively banning abortions as soon as a doctor can detect cardiac activity in an embryo, which typically happens at around six weeks into a pregnancy.

But doctors say that not only is that cutoff completely arbitrary, its also based on the false premise that a fetal heartbeat a phrase often included in the bills titles even exists at that stage of pregnancy.

To say that a six-week pregnancy has a fetal anything is incorrect, explained Dr. Colleen McNicholas, an obstetrician-gynecologist who performs abortions, noting that the term fetal heartbeat isnt even applicable until about 10 weeks into a pregnancy. At that point, an embryo has developed sufficiently to be called a fetus.

At six weeks, an embryos cardiac development doesnt at all resemble what would eventually become a functioning human adult heart, she said. At that point, it really is just these two tubes with a couple of layers of cardiac or heart cells that can vibrate or cause some sort of movement that we use colloquially to talk about a fetal heartbeat.

McNicholas is based in St. Louis, Missouri, where an appeals court is currently weighing one of the laws signed in 2019.

Governors in South Carolina, Oklahoma and Idaho have all signed similar bills similar to the one in Texas this year. However, they, too, are tied up by legal challenges.

Elijah Nouvelage via Getty ImagesPeople in Atlanta protest against Georgia's six-week abortion ban in 2019.

Dr. Carley Zeal, another OB-GYN based in St. Louis, expressed similar frustration with the fetal heartbeat terminology these bills are using.

An embryo at six weeks has no other functioning organs, no ability to live on its own, and its actually so small that when we review pathology from an abortion or a miscarriage at six weeks gestation, theres not an identifiable fetus to review, she said. Its just a gestational sac and some cells, so its very small and definitely not able to live outside of the womb.

At that point, an embryo is less than a centimeter long, she said. Thats smaller than a penny or the width of most peoples pinky fingers.

But the way the lawmakers orchestrating these abortion bans speak about pregnancy at that stage leaves a very different impression.

If there is a detection of a heartbeat, that child is a living human being, and you can no longer murder this child in its mothers womb, Kentucky state Sen. Matt Castlen (R) said at a press conference when introducing his states fetal heartbeat bill in 2019.

What were doing is ... recognizing that the child with a beating heart inside of mom thats got a heartbeat, that theyre preparing a nursery for, that is wiggling around inside mom, is actually a person,Georgia state Rep. Ed Setzler (R), the architect behind his states abortion ban, alsosaidthat year.

Science tells us that the heartbeat really is the beginning of life and the end of life, he added.

Science doesnt actually tell us that, said Zeal, who testified against the Missouri bill as part of her involvement with the group Physicians for Reproductive Health. The focus on the heartbeat as a cutoff date is completely arbitrary.

Theres a lot of talk from the other side about a heartbeat being the point at which a life begins, which is really based on their ideologies, she said. What we are trying to focus on as providers is to take it away from their black-and-white ideology and focus back on what is safest and what is the most effective care for our patients.

McNicholas agreed. From a medical standpoint, there is no single organ that we say defines life, she said.

To her, focusing on the heart is taking advantage of one of societys most deep-seated word associations. The heart is merely a muscle that pumps blood through someones circulatory system, but idioms like following your heart and a broken heart have given anti-abortion activists something that tugs at peoples heartstrings figuratively speaking.

I think that its a capitalization on our societys longstanding obsession and infatuation around the symbolism of the heart, she said. We use the heart visually in so many different ways to mean so many different things, and I think this particular approach really capitalizes on our obsession with the heart being a symbol of something.

Beyond lawmakers ignoring facts about embryology, theyre disregarding a huge practical issue: Many patients dont know theyre pregnant in the first six to eight weeks of pregnancy, both doctors said. Its common for patients who have irregular periods, thyroid issues, financial insecurities that limit their medical access and other atypical circumstances to miss or not have any early signs of pregnancy.

SOPA Images via Getty ImagesA demonstrator in Columbia, South Carolina, in February holds up a sign in favor of the state's six-week abortion ban.

But lawmakers supporting those bills are dismissing those common circumstances. Missouri state Rep. Barry Hovis (R) argued in 2019 that under his states bill, which estimated that a fetal heartbeat can be detected at eight weeks instead of six, patients would still have plenty of time to seek out an abortion.

Ive never really studied it, but Ive heard of the morning-after pill, where if someone feels theyve been sexually assaulted, they could go do that, he said at the bills final hearing. It gives them ample time in that eight weeks to make those exclusions.

We shouldnt give lawmakers a pass to play dumb, Zeal said.

Make no mistake, these bans are designed to ban almost all abortion, she emphasized. Legislators writing these bans understand that this would make almost all abortions that we do illegal and make it completely inaccessible to patients, and thats why theyre trying to get them through. Its not at all based on a womans health or a fetus health.

Although abortion remains legal in all 50 states, a serious threat to that looms. The Supreme Court announcedMonday that it would take up a case addressing whether all pre-viability prohibitions on elective abortions are unconstitutional a question that not only addresses six-week bans, but also outright bans governors in Alabama and Arkansas have tried to enact.

This is the first time the court has agreed to review an abortion ban since deciding Roe v. Wade in 1973, which has protected access to the procedure for 48 years.If the court reshaped into a firmly conservative body by former President Donald Trump decides in favor of such bans, the protections established in Roe v. Wade would be essentially tossed out.Twenty-four states hostile to the procedure would likely ban abortion outright, abortion rights activists warn.

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New method shows that tau forms small aggregates as part of the body’s normal physiology – News-Medical.Net

It turns out that not all build-ups of tau protein are bad, and a team of researchers from the Perelman School of Medicine at the University of Pennsylvania developed a method to show that. Using mammalian cell models, the researchers combined extremely high-resolution microscopy with machine learning to show that tau actually forms small aggregates as a part of the body's normal physiology.

Through this, they could distinguish between the aggregates occurring under healthy conditions from the ones associated with neurological diseases, potentially opening the door to screening for treatments that might break apart harmful aggregates. This research was published in the Proceedings of the National Academy of Sciences of the United States of America.

"There aren't many tools that can visualize small, pathological protein aggregates within cells," said the study's senior author, Melike Lakadamyali, PhD, an associate professor of Physiology. "But through machine learning informed by super-resolution microscopy, we believe we've been able to show that tau forms both normal physiological aggregates and distinct pathological aggregates. In doing so, we created a useful method that could be the basis for new research into the appropriate treatments for tau-related pathologies."

Tau is a protein that attaches to the microtubule structure of axons - which act much like highways in nerve cells. Previously, tau aggregates had been thought to only form once tau falls off the microtubules. These have been associated with some neurological diseases, including Alzheimer's and other types of dementia. However, it turns out that small tau aggregates can also form outside disease conditions.

Intrinsically, there is value in being able to tell which tau aggregates are a part of a healthy person's nervous system, and which have formed harmful aggregates. Unfortunately, there has not been a process sensitive enough to make that distinction yet inside cells. So we set out to create one using mammalian cell models."

Melina Theoni Gyparaki, Study Lead Author adn Doctoral Student in Lakadamyali's Lab

First, the researchers used extremely high resolution microscopes capable of looking at single molecules to differentiate physiological and pathological oligomers (molecular formations). Monomers, dimers and trimers, which are oligomers made up of one, two, and three tau molecules, respectively, were most likely to end up associated with healthy physiological conditions because they were associated with microtubules and regular function.

When the team looked at tau structures associated with a mammalian cell model approximating frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) - a disease associated with tau aggregation - the structures were larger and more complex. These appeared to be the pathological tau aggregates that broke off.

With the differences in configuration established, the researchers created a machine learning algorithm to classify the pathological tau aggregates by shape alone. Additionally, they used antibodies that can detect and differentiate when the tau aggregates become "hyper-phosphorylated" - when they pick up a lot of phosphate groups and tend to harmfully break off. Combining these methods showed that tau containing phosphate groups on certain amino-acids was more likely to form linear fibrils, a thin structure, as opposed to other shapes of tau aggregates.

"The method we developed to identify tau aggregates is not yet a diagnostic tool, but we think it would be a useful research tool for anyone interested in studying the mechanisms that lead to pathological protein oligomerization in neurodegenerative disease," Lakadamyali said.

Tau aggregates aren't the only ones that this method could be used to classify, either. There's an opportunity to use it on other potentially pathological protein build-ups, such as alpha-synuclein, which is associated with Parkinson's disease, or huntingtin, related to Huntington's disease. It could also be used to screen for potential treatments for these conditions that don't harm the body's regular protein complexes.

The team is now studying potential mechanisms for clearing tau aggregates and determining what other pathways could be helpful in this regard.

"We are also further using the method we devised to visualize tau aggregates in human postmortem brain tissue slices from Alzheimer's disease to determine the role of tau's post-translational modifications in aggregation," Lakadamyali said.

Source:

Journal reference:

Gyparaki, M. T., et al. (2021) Tau forms oligomeric complexes on microtubules that are distinct from tau aggregates. Proceedings of the National Academy of Sciences. doi.org/10.1073/pnas.2021461118.

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New method shows that tau forms small aggregates as part of the body's normal physiology - News-Medical.Net

Bizarre ‘stomach’ case put Plattsburgh on the map – Plattsburgh Press Republican

PLATTBURGH -- French-Canadian Alexis St. Martin returned several times to the United States, where hundreds of physiological experiments were conducted on him by Dr. William Beaumont,The Father of Gastric Physiology.

CUTTING-EDGE RESEARCH

In 1833, Beaumont's notes and drawings were consolidated in a book, Experiments and Observations of the Gastric Juice and the Physiology of Digestion published by by F. P. Allen, a local newspaper publisher in Plattsburgh.

The book was later published in Great Britain, France, Germany and Scotland.

Dr. Paolo Fedi of Beaumont Gastroenterology Services was able to secure a first-edition copy of the rare tome.

The book was poorly published because this was a newspaper, Fedi said.

It was not a publication that was done in a bound book. Beaumont never used any of the important universities at that time. He never connected with them. So this book, a few copies remained.

Medical interest surged in Beaumont's research and his study of St. Martin.

Everybody wanted him to come to their place, but this guy refused to connect further, Fedi said.

He went into Canada and disappeared from any public venue. He didn't want to have anything anymore.

SUCCESSFUL PRACTICE

St. Martin would not meet in St. Louis with Beaumont, whowas stationed there in 1830 and was appointed Surgeon at Jefferson Barrack and later the Arsenal.

About 1835, he took up his residence in St. Louis and two or three years later he resigned from the Army and took up private practice, according to his obituary.

Beaumont lived in St. Louis 19 years, where he was appointed Professor of Surgery at Saint Louis University's Medical Department.

He died (April 25, 1853) after a slip on the ice while he was going to see a patient, Fedi said.

Beaumont is buried in Bellefontaine Cemetery in St. Louis as his wife, Deborah Greene Beaumont (1799-1870) and their daughter, Sarah Beaumont Keim (1825-1913).

Their son, Israel Greene Beaumont (1829-1901 is buried in the Woodlawn Cemetery in Green Bay, Wisconsin.

Living in Plattsburgh here, he had an office where the store that is now called Ashley Furniture is, Fedi said.

He had an office and practice there. There is a plaque there that was placed by the Medical Society, I think in the '70s.

After his publication, he was able to determine that the stomach is able to digest food because it produces acid. They called it at the time muratic acid. Now, it's what is called hydrochloric acid. Before that we did not know the stomach was producing acid. The science at the time held food sat or putrefied in the stomach.

Beaumont's experiments with St. Martin proved and demonstrated otherwise.

That made an explosion of research everywhere, Fedi said.

His work was really fundamental to the understanding of the digestion of the GI tract.

He was a great observer. He was able to kind of look at the stomach and he realized that the weather, the stress of different things was able to affect the stomach of the GI tract, illnesses.

So when Alexis was drinking too much, they were able to see that his stomach wasn't really healthy, and it was taking much longer to digest than what was normal.

The pioneering medical researcher also noticed similar outcomes for the effects of tobacco on the stomach.

Beaumont put Plattsburgh on the map for medical history because at that time there was not really major hospital or any other things here, Fedi said.

Because of the Army base and him, it became an important site.

PARTED WAYS

St. Martin, born April 8, 1802 in Berthierville, Quebec, died June 24, 1880 in Saint-Thomas de Joilette in Quebec.

The wood chopper fathered 22 children, and his burial site remained secret until 1962.

He was so worried that somebody would come and get even when he was dead, he left a will that stated his body should be left to decompose for four or five days before he was put in the ground and one should know where the body would be, Fedi said.

Alexis Bidagan dit St-Martin is buried at St. Thomas Parish Cemetery in Joliette, Quebec.

A great-niece of his made it public that he was actually buried in the cemetery of a specific church, so they were able to put a tombstone with his name and other things," Fedi said.

"It is just outside of Montreal.

Beaumont name's graces the Beaumont Hall Science Building at SUNY Plattsburgh, the William Beaumont Army Medical Center in El Paso, Texas, and the largest health care system in Michigan.

It's still amazing that many people do not know anything about this history, Fedi said.

I have medical practice called Beaumont. Many people are like 'You're Italian, why do you use this French name?'

I love history. I'm fascinated with the idea that I can use his name for a practice of the GI tract.

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Twitter:@Robin Caudell

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Bizarre 'stomach' case put Plattsburgh on the map - Plattsburgh Press Republican

Luke Heckmann, UT21 Senior – UT News – UT News | The University of Texas at Austin

Going up to the hives was always a thrilling, but also exhaustingly hot, experience, Heckmann says. We would wear those big white beekeeper suits with the meshed veil to protect ourselves, and we would use smoke canisters to get the bees to fly into the hive and make it simpler to open and remove frames.

As an undergraduate, Heckmann was part of the Moran Lab, which was investigating ways to protect honeybee health for thriving ecosystems. Researchers focused on studying a particular species of bacteria living within the bees guts.

While working directly with and gathering data from the bees, Heckmann edited circular rings of bacterial DNA known as plasmids. Ultimately, Heckmann and the group discovered a way to genetically modify that gut bacteria to enable the cells of bees to fight off deadly viruses and mites.

It was his biggest and proudest accomplishment yet, taking multiple years of work and an enormous number of hours from many different people, Heckmann says. So it was just a huge, huge achievement for all of us really after so many years.

Later, Heckmann even received funding from a Undergraduate Research Fellowship to further expand upon that research. And even after COVID-19 hit, he was able to continue that work remotely.

Research has formed his undergraduate experience, but Heckmann says his ultimate goal is to become a doctor. Never boxed in, he actually aspired to be an engineer growing up. He was always interested in the mechanics and moving parts of anything and everything, but in high school, Heckmann took a transformative anatomy and physiology course, opening his eyes to a future in medicine.

It wasnt until that anatomy class I took, where I really started seeing things from a different perspective. You sort of see that the body is almost like the most finely tuned machine, Heckmann says.

Heckmann, born in Oklahoma but basically an Austin native after having moved here when he was 2, says it was a no-brainer applying and committing to UT Austin for its academic rigor and great location. Upon arrival, he quickly combined his interests in engineering and the natural sciences to pursue biomedical engineering.

Heckmann says some of his favorite courses were Organic Chemistry I and II, which focused on studying carbon, the building block of life, and Tumor Biology, which investigated core aspects of cancer pathology, treatment and epidemiology with molecular biosciences professor Jon Huibregtse.

Glancing over at a whiteboard in his room, he says it is filled with notes from that course. I still have a bunch of diagrams because theyre just so satisfying to look at, he says, laughing. That class was incredible and really pertinent because cancer is unfortunately so common.

As a graduating senior, Heckmann cannot recommend doing research as an undergraduate enough. Id honestly encourage everyone to try and seek out a research opportunity. He says: I learned a ton from conducting research and being a part of a lab and a group of people, or a community, if you will. A lot of things I learned in the lab werent even research-related, but just related to life in general.

Looking past graduation, Heckmann is ready to bring his skills to medical school. The great thing about UT is that it does a really good job at equipping us with different skills and different opportunities that are life-lasting. When experiments fail, I had to adapt over and over again in the face of new information, and that adaptability will be vital for me as a future physician.

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The Answer to the Andorians Blue Skin is in Their Blood – Heavy.com

YouTubeAndorians from "Star Trek: Enterprise"

The blue-skinned Andorians are one of the most distinctive species in the Star Trek universe. Though the appearance of the species has changed significantly from show to show, a few characteristics have remained consistent. Andorians have small forehead ridges, a pair of antennae, white hair and bright blue skin.

The Andorians were first introduced in the episode Journey to Babel from Star Trek: The Original Series. Veteran Star Trek writer Dorothy Fontana created the species specifically for the episode.

Her original notes revealed little about the species, though they did reveal why they were blue. However, her explanation is very different than the reason that became part of the Star Trek canon.

Albert L. Ortega / Getty Images

When Star Trek was brand new in the 1960s, the writers got the opportunity to create new species all the time. Each of the different species that fans are familiar with today was created from scratch by the writers. In fact, many of them were created by Fontana herself.

Often, these new species were born from an interesting concept or makeup idea. This was the case with the Andorians.

A makeup and costume memo Fontana wrote for Journey to Babel stated, Andorians are pale blue. Because.

Fontana didnt include much more information about the Andorian physiology, other than their antennae, or provide a further reason for their distinctive appearance. Few details were included about their culture either, with the exception of the fact that they were fierce warriors.

For decades, the Andorians were rarely seen in Star Trek shows. They made a couple of appearances in Star Trek: The Animated Series and Star Trek: The Next Generation but were completely absent from both Star Trek: Deep Space Nine and Star Trek: Voyager.One likely reason for the lack of Andorians was the complicated makeup, which was both costly and time-consuming.

Because the Andorians appeared so rarely, there werent any opportunities to learn about their physiology or culture until Star Trek: Enterprise. Showrunners Rick Berman and Brannon Braga decided that they wanted to bring the Andorians back in the prequel show and make them a major part of the series. They worked with the visual effects department to completely redesign the makeup and antennae. The result was a much more believable and striking species.

Bringing the Andorians back also meant expanding their backstory and making them a more complex species. According to The Fifty-Year Mission: The Next 25 Years, the Enterprise writing staff, with Fred Dekker taking the creative lead, was tasked with creating all the details about the Andorians that were left out of the previous series. They fleshed out the Andorian physiology, psychology, and culture episode by episode.

In one of the Andorian-centric episodes, United, the Andorians blue skin was finally given a canonical explanation. During that episode, Lieutenant Talas was fatally wounded. The blood from her wounds was the same shade of blue as her skin. This suggests that the Andorians skin is somewhat translucent, allowing the pigment of the blood to show through.

This canonical explanation doesnt fit with the physiology of other alien species in the Trekverse. The Vulcans and Romulans have green blood, but their skin doesnt reflect the color of their blood. Klingons usually have red blood, though in Star Trek VI: The Undiscovered Country, they inexplicably have pink blood. Klingon skin color is almost always brown, with the exception of the Albino in DS9 and the albinos in Star Trek: Discovery. So, their skin doesnt reflect their blood color either.

In humans, skin color has nothing to do with the color of the blood. According to the Smithsonian, human pigmentation is the result of melanin. The more melanin, the darker the skin, the less melanin the lighter the skin. Since Vulcans, Romulans, and Klingons all have skin colors that have nothing to do with the color of their blood, it follows that their skin color is the result of an alien equivalent of melanin. If the Andorians really do get the color of their skin from their blood, it follows that their skin doesnt have its own pigmentation.

However, this explanation doesnt even make sense within the canon created by Enterprise. In the episode The Aenar, a subspecies of Andorians called Aenar were discovered by Shran and Archer. They were considered a myth by most Andorians since they were isolated to the harshest environments of the planet.

The Aenar have white skin with just a hint of blue in it. They were described as albino Andorians, which implies that their skin lacked pigmentation entirely. Since the Aenar evolved from the Andorians, this suggests that the Andorians do, in fact, have pigmented skin. So, the color of their blood shouldnt impact the color of their skin.

Whether it makes sense or not, the established in world canon is that Andorians blue blood makes their skin blue. Of course, the real reason is that Fontana just felt like making a blue alien.

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The Answer to the Andorians Blue Skin is in Their Blood - Heavy.com