New provost will be a "student of Yale" – Yale Alumni Magazine

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Since arriving at Yale in 1995, Scott Strobel, now the Henry Ford II Professor of Molecular Biophysics and Biochemistry, has taken on a series of administrative roles: chair of his department; vice president for West Campus planning and program development; deputy provost for teaching and learning; and vice provost for science initiatives. Now, in his highest-profile assignment yet, Strobel has been tapped by President Peter Salovey 86PhD as Yales new provostthe universitys chief academic and budgetary officersucceeding Ben Polak, who is returning to the economics faculty.

Strobel grew up around science, playing in the lab of his father, a plant pathologist at Montana State University. (I was probably doing stuff you shouldnt really let a kid do in a lab, he says.) He obtained his undergraduate degree in biochemistry from Brigham Young University, earned his doctorate at Caltech, and did postdoctoral work at the University of Colorado.

The other major influence in his early years: membership in the Bozeman Hawkers, his high schools speech and debate team. Being on that team transformed who I was and what I realized I could do, Strobel says. Its where I became comfortable in front of a classroom and in public settings.

Strobels dedication to the classroom is evidenced by the several Yale and national awards he has won for teaching and mentoring. He also oversaw the creation of Yales Poorvu Center for Teaching and Learning, accessible to everyone in Sterling Library. Its glass walls, he notes, are a reminder that teaching is a public experience that should be shared in a community of scholars.

When Strobel first moved into administration, he continued teaching his award-winning Rainforest Expedition and Laboratory course, a spring-term and summer undergraduate biology class that took Strobel and his students to the South American rain forest to analyze microorganisms they found in plant tissues. Eventually, he stopped teaching to focus on administrative responsibilities, including transforming a vast former pharmaceutical research complex into Yales West Campus, which now houses seven interdisciplinary institutes as well as the School of Nursing. (In his off hours, he has turned his wood-turning hobby into a business: he makes bowls and pens with wood salvaged from trees on the Yale campus that have been removed because of overgrowth, disease, or construction.)

When his appointment was announced in November, Strobel set a goal of meeting with every dean and speaking to as many faculty members as possible to better understand the totality of the university, pledging to be a student of Yale as well as one of its leaders. And hes not willing to give up teaching entirely: he plans to guest-lecture next spring in Donald Engelmans Biology, the World and Us, an introductory science course for nonscience majors.

Being offered a position at Yale 25 years ago was a dream come true, Strobel says. I hoped it would be an institution where my two passions of teaching and research were fully integrated. I am deeply grateful to President Salovey for the trust he is placing in me to help shape Yales future, and to determine how best to use its resources to help improve the world.

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New provost will be a "student of Yale" - Yale Alumni Magazine

Meet Silicon Valley’s own Willy Wonka and his chocolate-making robot – Palo Alto Online

Only in Silicon Valley does a longtime tech startup founder find a second career in a chocolate-making robot.

Nate Saal studied molecular biophysics and biochemistry at Yale University after graduating from Palo Alto High School in 1990. After returning to Palo Alto, he quickly shifted from science to the internet, founding what he says was the first web-based software updating service in 1996. He went on to start more technology companies and later worked for CNET and Cisco.

But these days, he's immersed in chocolate -- specifically, chocolate made by a countertop device that he created called CocoTerra. The sleek white device, which looks like a large, futuristic coffee maker, uses algorithms, hardware and a smartphone app to transform cocoa nibs, milk powder, cocoa powder and sugar into chocolate in about two hours.

Saal has high hopes for the machine, which has yet to be released. In the age of automation, where robots are making pizza and ramen and delivering our food, he sees CocoTerra as doing something different: using technology to deepen rather than disrupt people's connection to how their food is made.

"We're not trying to slap technology for technology's sake on top of that to abstract it away, to take creativity away," he said. "We're trying to actually create a whole new category of people who can now make chocolate."

While Saal's professional career has focused on technology, he has always filled his weekends with homegrown food experiments, like keeping bees and growing grapes and olives to make wine and olive oil from scratch. He's fascinated by the "deep science" of these activities.

Making chocolate, however, was not in his repertoire. It wasn't until he took his brother-in-law, who works in the coffee business, to a chocolate tasting several years ago, and a conversation about the similarities between the two industries got him thinking. His brother hypothesized that home coffee machines have allowed more people to understand and appreciate coffee in a way that chocolate hasn't experienced. People did make chocolate at home, but it was a lengthy process that required having several expensive appliances, he found.

"There's a bread machine, an ice cream maker and a juicer and a pasta maker and a tea brewer and a coffee maker -- every major food category has a home appliance. What I discovered very quickly was there is no such thing (for chocolate)," Saal said.

He educated himself by going to chocolate-making classes, including a boot camp at Madre Chocolate in Hawaii. Back in Palo Alto, he and a team got to work designing a device that could combine all steps in the chocolate-making process -- grinding, refining, conching, tempering and molding -- in one machine. It typically grinds the single-origin cocoa nibs for about half an hour, using stainless steel balls, then refines the cocoa butter, sugar and milk powder. Conching is the "slow manipulation or agitation of chocolate at elevated temperatures to help drive off some undesired flavors," said Chief Operating Officer Karen Alter. Named for conch shell-shaped equipment, this is part of the process is often on display during chocolate factory tours, she said, with large vats that have paddles slowly moving liquid chocolate.

The next step, tempering, involves cooling the ingredients to a specific temperature that will create a specific structure of seed crystal in the cocoa butter molecules, Saal enthusiastically explained. The crystals solidify, creating shiny, hard chocolate. A patented centrifuge inside the machine cools and spins the chocolate to remove bubbles.

The final result is a ring-shaped, half-pound mold of chocolate, rather than the traditional rectangular bar.

On the back end, technology allows a level of customization that CocoTerra's creators hope will make the device as appealing for experts as for novices. A cloud-based recipe system, accessible online or via an app, guides you from start to finish in a recipe. People can either default to CocoTerra's recipes, such as 62% dark chocolate or milk chocolate with almonds, or customize them, from level of sweetness and creaminess, to added flavors and ingredients, to the tempering temperature. People can easily control for allergies or dietary restrictions.

CocoTerra will sell the base ingredients directly to customers, focusing on fair trade, ethically grown nibs, or people can use their own. Those who are advanced enough to roast and shell their own cacao beans could still do that, put them into the machine and then create their own recipes.

Producing quality chocolate in two hours is "jaw-dropping" to many in the chocolate industry, Saal said.

"I thought they were totally crazy when I first talked to them on the phone," John Scharffenberger told CNBC. Scharffenberger, who co-founded Scharffen Berger in San Francisco in 1997 before small batch, artisan chocolate was a thing, is now a CocoTerra investor and calls it "a natural extension of the craft chocolate movement."

The company won't disclose a price for the machine, which they claim is the world's first tabletop chocolate maker. CocoTerra has raised more than $2 million in investments and is now focused on a larger round to fund the release of the device.

"This is about the evolution of technology to make chocolate. But it's also making it accessible," Saal said. "We're bringing that to people by using smart mechanical engineering and software to make it accessible so that you can actually now focus on things like the flavor and recipe and the look and the design and the craft of it."

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Meet Silicon Valley's own Willy Wonka and his chocolate-making robot - Palo Alto Online

Study focuses on key structure of C. difficle bacteria that could lead to future treatments – Business Standard

You are here Home Video Gallery Study focuses on key structure of C. difficle bacteria that could lead to future treatments Study focuses on key structure of C. difficle bacteria that could lead to future treatments

New Delhi, Jan 06 (ANI): Researchers have identified the structure of the most lethal toxin produced by certain strains of Clostridium difficile bacteria, a potentially deadly infection associated with the use of antibiotics. The finding of the study was published in the journal of Proceedings of the National Academy of Sciences.

Researchers at the University of Maryland School of Medicine and their colleagues used cryo-electron microscopy, X-ray crystallography and other biophysical methods to identify the microscopic structures of the bacteria. The researchers mapped out the delivery and binding components of the toxin, which could pave the way for new drugs to neutralize it.

"We identified two structures that help explain the molecular underpinnings of C. difficile toxicity," said study co-author David Weber, Ph.D., a Professor of Biochemistry and Molecular Biology and Director of the Center for Biomolecular Therapeutics at UMSOM.

"These structures will be important for targeting th

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Study focuses on key structure of C. difficle bacteria that could lead to future treatments - Business Standard

Seven to receive 2020 Alumni Awards – News – Illinois State University News

David DeMarini 72, M.S. 74, Ph.D. 80, accepts the 2019 Distinguished Alumni Award.

Each yearIllinois State Universitys Alumni Association recognizes alumni for their outstanding contributions to their fields, their impact on society, and their passion for Illinois State through the Alumni Awards program. This year seven individuals will be honored at the Annual Awards Dinner:

Distinguished Alumni AwardJay D. Bergman 70CEO and chairman, Petco Petroleum Corp.Major/College: Business administration, College of Business

Alumni Achievement AwardDaniel Wagner 89, M.S. 94Senior vice president of government relations, Inland Real Estate GroupMajor/College: Political science, College of Arts and Science

Senator John W. Maitland Jr. Commitment to Education AwardDamian K. GregoryFounder and executive director, Gridiron Group

E. Burton Mercier Alumni Service AwardBeverly Grimes 60Retired nurseMajor/College: Nursing, Mennonite College of Nursing

Outstanding Young Alumni AwardPaul DeJong 15Shortstop, St. Louis CardinalsMajor/College: Biochemistry, College of Arts and Science

Jenna Goldsmith 08, M.S. 10Instructor of Writing, Oregon State University-CascadesMajor/College: English, College of Arts and Science

Griffin Hammond 07, M.S. 09Documentary Filmmaker, Recount MediaMajor/College: Television/Communication, College of Arts and Science

Nominations are also being sought for the 2021 Alumni Awards. The deadline to submit is May 31, 2020.

A quick summary how to recognize outstanding alumni.

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Seven to receive 2020 Alumni Awards - News - Illinois State University News

To the stars and beyond: A hundred years of Isaac Asimov – Hindustan Times

In a completely unscientific survey I conducted for the express purpose of writing this article, I sent a WhatsApp message to many of my (what I hoped were) sci-fi reading friends asking what they thought Asimovs greatest work (or their favourite Asimov work) was. The answers did not surprise me; there was absolutely no consensus. Everyone who had read Asimov had a different answer. Bicentennial Man and End of Eternity FTW! replied one. Some would say the Robot stories, but Foundation is more in-depth, answered another. Robot Dreams, said a third; his short stories definitelyespecially the AI ones, pinged a fourth; Nightfall. No questions there! said a fifth with complete confidenceand so on.

Of course, there was also one who said whos Asimov? Horrified, I explained that he was an acclaimed writer whose work had been made into several movies. Havent you seen I, Robot? I asked. Is that the one with Rajinikanth? came the tentative reply.

Message received. Asimov isnt everyones cup of tea.

But for those of us who revel in the scientific accuracy of fantastic worlds, in the possibility of reimagining the mundane into never-impossible futures, and found ways of thinking about the Big Questions of life through the stories of Multivac and lands where stars were only seen once in a thousand years, Isaac Asimov is a prophet (peace be upon his name).

A Russian immigrant in the USA in the 1930s, a professor of biochemistry, a war veteran, and a writer of popular science books, Isaac Asimov whose birth centenary it was on 02 January was also, possibly, the most successful science fiction writer of his generation.

His mind-bending stories of inter-stellar travel, other worlds, strange encounters, and sentient machines have never stopped fascinating readers since he first put finger to typewriter. One of the most prolific of writers, he has authored more than 500 books, edited several volumes, and all of this while also being a professor of biochemistry.

Born in a village called Petrovichi in Smolensk, Russia somewhere between October 1919 and January 1920, Isaac Asimov decided to celebrate his birthday on 02 January. He wrote in In Memory Yet Green, It could not have been later than that... There is, however, no way of finding out. My parents were always uncertain and it really doesnt matter. I celebrate January 2, 1920, so let it be.

The Asimovs emigrated to the USA in 1922, and after struggling for three years, managed to save enough money to open a small candy store in New York. It was there that a young Isaac discovered science fiction in the form of magazines lying around in the store and also discovered the incomparable joy of reading and getting lost in the pages of a good book.

Isaac Asimov discovered he was a storyteller in school, and soon even before he had turned 12 was already trying his hand at writing them. He also wrote a detailed daily journal, complete with baseball scores, and had a dedicated following as a teller of tales he had read in magazines and books. But before he ever wrote science fiction, as a teenager, he had first tried his hand at fantasy.

In Its Been a Good Life a compilation of Asimovs diary entries, personal communications, and a condensation of his earlier autobiographies he writes about the first piece of fiction he ever attempted to write on the used typewriter his father had bought him: (it was a story of) a group of men wandering on some quest through a universe in which there were elves, dwarves, and wizards, and in which magic worked.

This was in the year 1935. Asimov was 15, and JRR Tolkiens The Hobbit wasnt published till 1937 (The Lord of Rings trilogy, which pretty much set the template for fantasy fiction for the next several decades, would only be published twenty years later between July 1954 and October 1955). It was as though I had some premonition of JRR Tolkiens Lord of The Rings, writes Asimov. But for better or worse, it didnt stick.

By the mid-1930s, Asimov was an avowed sci-fi fan, writing letters to science fiction magazines and even joining fab clubs. And by 1938, as an undergraduate chemistry major at Columbia University, he had written his first complete science fiction story and went to the New York offices of the Astounding Science Fiction magazine to meet the editor and submit it for publication. The Editor John Campbell, who is credited with having found and nurtured an entire generation of science fiction writers, and went on to become Asimovs trusted friend and editor for many years to come rejected the piece, with a cordial letter that explained to the young Asimov why the story didnt work and how he could get better. It would take nine more rejections before Asimov was finally published in another magazine called Amazing Stories.

For a writer so dedicated to his craft and one who wrote as much as he did, it took Asimov another twenty years to be able to earn enough to live off writing full time. In the meanwhile, he finished his Bachelor of Science degree, spent three years as a civilian chemist in World War II in Philadelphia, returned to New York and earned his doctorate in chemistry, and got a job as professor of biochemistry in Boston.

Till then and after, he wrote some of science fictions best loved stories. Stories of 200 year old robots who wanted to be human (The Bicentennial Man); of elections in an age where computers could predict the mood of the nation with a sample size of one (Franchise); of super computers who had all the knowledge of the world, and couldnt yet answer one important question (The Last Question), and a history of a future in which a great civilisation came to an end (Foundation)

But he was more than just a teller of made up stories. He was really invested in the science he wrote about, and the great pains he took to keep the science realistic in his stories is matched only by the pleasure he took in the research of it all. The simple evidence of how deeply he cared about the science of his stories is in the number of nonfiction books he wrote. He was as proud of being a science writer as he was of being a science fiction writer. Having written on subjects as varied as nuclear physics and human biology; Asimov the polymath is the poster child of multi-disciplinarity and academia as at ease in the hard sciences as in sociology and history; as eager to learn and read when he became a full professor as he was as a teenager; and able to write in a clear and concise manner in fiction and science.

An atheist all his life, Asimov was a member of the humanist movement, and believed that human beings are responsible for the progressive advancement of society, and must step up and alleviate the ills of society themselves, instead of depending on supernatural forces. He even went so far as to sign the Humanist Manifesto in 1970. His two volume Asimovs Guide to the Bible is also written from a strictly humanist point of view.

It is a vision reflected in his stories, in his hopes for possible futures. In 1984 35 years after George Orwells grim book of that name was published Asimov was asked by the Toronto Star to predict what the world might look like 35 years from then (in 2019), and he managed to get quite a bit right. Even though we havent come to a point where we can live under the faint semblance of a world government by co-operation and we havent shifted polluting industries in a wholesale manner to space; he did foresee the human races increasing reliance on computers and predicted that mobile computerised objects would penetrate the home. He also predicted that there would have to be a vast change in the nature of education because wed have to learn to live in an increasingly high tech world.

Asimov, above all, was an optimist someone who was sure that the inherent good in enough members of the human race would outrun the evil forces and keep humans going for millennia to come. Oh the robots we would build! And the galaxies we would colonise! What adventures we would have! It is a world view that recognises the challenges of war and natural disasters and discrimination; but it is filled with hope for a better future, a fantastic future, a kinder future.

Isaac Asimov was possibly the most successful science fiction writer of his time.(Getty Images)

Little Known Facts About Isaac Asimov1. When Isaac Asimov was about two years old, 17 children in his village, including Isaac, contracted double pneumonia a disease in which both lungs become inflamed, making it near impossible to breathe. All but Isaac died. He credits his survival to his mother, who after the doctor had given up on him, held baby Isaac in her arms without ever letting go until he was better.

2. Though he wrote extensively about interstellar travel, Asimov was afraid of flying, and almost never took flights.

3. Asimov was fond of music and thought of Tchaikovsky as music that makes me feel happy and Beethoven as music that makes me feel awed.

4. He wrote more than science and science fiction! Asimovs Guide To The Bible was written in two volumes in 1968 and 1969. And in 1970, he wrote Asimovs Guide To Shakespeare. He organised the plays not as tragedies, comedies, and histories (as is usually done) but by region Greek, Roman, Italian, English. Other than writing his autobiographies, Asimovs Guide To Shakespeare was according to him the most pleasant work Ive ever done.

5. Paul McCartney, in 1974, asked Asimov if he would write a screenplay for a science fictional movie musical about a band whose members were being impersonated by aliens. Asimov wrote it, but it was never made (speculation is that it had been rejected because Asimov neglected to use the scraps of dialogue that McCartney had suggested).

6. Apart from his own (what he called legitimate) PhD, Asimov was awarded 14 honorary doctorates in his lifetime.

7. When Asimov had a triple bypass surgery in 1983, he contracted HIV from a bad blood transfusion. In 1990, Asimov and his wife Janet Jeppson Asimov found out about it but they did not go public with this information on the advice of his doctors. It was not revealed even when he died in 1992 of heart and kidney failure caused by AIDS. The truth came to light in 2002, when Janet revealed it in the epilogue to Its Been A Good Life.

8. In September 1983, Asimov met Indira Gandhi, when she was in New York City to attend the UN General Assembly. She was a gracious and intelligent woman, he wrote about the meeting.

9. A fan of Sherlock Holmes, Asimov was a member of the official fan club The Baker Street Irregulars; and even wrote a song (to be sung to the tune of Danny Boy) in praise of the detective for an annual dinner of the club. The first few lines were: Oh, Sherlock Holmes, the Baker Street Irregulars/ Are Gathered here to honour you today,/ For in their hearts you glitter like a thousand stars,/And like the stars, youll never fade away.

The Laws Of RoboticsOne of Asimovs most memorable contributions to the world are his Three Laws of Robotics. While scientists and others have written their own laws since, Asimovs were the first, most popular, and remain at the heart of all other laws of robotics. They have also formed the bedrock of much of sci-fi involving robots. Many writers have written stories, simply assuming the laws as fact.The Laws as Asimov wrote them:1. A robot may not injure a human being or, through inaction, allow a human being to come to harm.

2. A robot must obey the orders given it by human beings except where such orders would conflict with the first law.

3. A robot must protect its own existence as long as such protection does not conflict with the first or second laws.

Asimov credits his friend and publisher John Campbell with having come up with them.

It was at a meeting between Asimov and Campbell where Campbell was actually rejecting one of Asimovs stories that the idea for the laws emerged. Asimov was pitching a story about a robot that had become capable of reading minds due to a minor mistake on the assembly line.

And as they talked of the complications that robot telepathy might present, Campbell said, Look, Asimov, in working this out, you have to realize that there are three rules that robots have to follow. In the first place, they cant do any harm to human beings; in the second place, they have to obey orders without doing harm; in the third, they have to protect themselves, without doing harm or proving disobedient. Well ...

The Writers Personal FavouritesIn 1968, Asimovs story Nightfall was voted the best science fiction short story ever written, by the Science Fiction Writers of America, and many think that honour still holds.

But what were Asimovs favourites from among his own work?

Helpfully, he has answered the question himself. His own three favourite short stories were, in descending order:

(1) The Last Question

(2) The Bicentennial Man

(3) The Ugly Little Boy

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To the stars and beyond: A hundred years of Isaac Asimov - Hindustan Times

PROBE conference to reflect on incredible role of physiology in life sciences – The News International

PROBE conference to reflect on incredible role of physiology in life sciences

The Department of Physiology at the University of Karachi is holding a three-day PROBE (Physiology Resonates and Ozonizes Biological Existence) 2020 Conference from Tuesday. Sindh Women Development Minister Syeda Shehla Raza will be the chief guest of the inaugural session.

KU Department of Physiology Chairman Prof Dr Taseer Ahmed said researchers and scholars will attend the biennial scientific meet-up. He said PROBE includes keynote sessions, plenary lectures, and oral and poster presentations. Themed Molecules to Mechanisms, the conference will reflect on the contemplative and incredible role of physiology in life sciences.

Dr Ahmed said the conference will be inaugurated at 3pm by KU Vice-Chancellor Prof Dr Khalid Mahmood Iraqi, and it will be attended by Minister Shehla, also an alumnus of the department.

Among other guests will be Pakistan Medical Commission member Prof Dr Rumina Hasan, former KU VC and physiology alumnus Prof Dr Pirzada Qasim, and world renowned scientists, including former Pakistan Council for Science & Technology chairman Prof Dr Anwarul Hasan Gilani and Prof Dr Ahsana Dar Farooq.

Dr Ahmed said students and intellectuals from nationwide institutions, including the Bahauddin Zakria University (Multan), the Islamia University (Bahawalpur), the University of Health Sciences (Lahore) and the University of Sindh (Jamshoro), are participating in PROBE.

Four pre-conference workshops will be conducted on Monday, namely Medical Social Work: An Opportunistic Field, A Hidden Treasure, Structural Bioinformatics: Discover the World Unknown to Many, Handling, Ethics and Ultrasound Applications on Laboratory Animals, and Life in Vivo: Non-Invasive Lab Techniques in Physiology.

The conference is partnered with the Pakistan Physiological Society and the South Asian Association of Physiologists. Dr Ahmed said the event is supported by the Higher Education Commission Pakistan, the Pakistan Science Foundation, the Office of Research Innovation & Commercialisation, and the World Poultry Science Association.

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PROBE conference to reflect on incredible role of physiology in life sciences - The News International

Pune to host fifth edition of global Drosophila conference – The Hindu

The city is set to host the fifth edition of the Asia Pacific Drosophila Research Conference (APDRC5), which is being organised in the country for the first time by the Indian Institute of Science Education and Research (IISER).

This biennial conference, which is to be held between January 6 and 10, aims to promote the interaction of Drosophila researchers in the Asia-Pacific region with their peers in the rest of the world. It will bring together scientists from all over the world who use the fruit fly, Drosophila, as a model organism to address basic and applied questions.

Drosophila is one of the most widely-used and preferred model organisms in biological research across the world for the last 100 years. Several discoveries in biology have been made using this. Its genome is entirely sequenced and there is enormous information available about its biochemistry, physiology and behaviour, said professor (biology) Sutirth Dey of IISER.

The event will feature 430 delegates: 330 Indian and 100 foreign. It will see the participation of two Nobel laureates, professors Eric Wieschaus and Michael Rosbash, known for their seminal contribution to the fields of development biology and chronobiology respectively.

Prof. Wieschaus, an American evolutionary developmental biologist, shared the Nobel in Physiology in 1995 with Edward B. Lewis and Christiane Nsslein-Volhard for his work on genetic control of embryonic development, while Prof. Rosbash shared the Nobel in 2017 in Physiology along with Michael Young and Jeffrey Hall for their discoveries of molecular mechanisms controlling the circadian rhythm.

This event is one of the largest meetings of Drosophila researchers in the whole world and attracts scientists working in diverse disciplines ranging from cell and molecular biology to ecology and evolution, said Prof. Dey.

Explaining the choice by the APDRC board of IISER to organise the meet, he said the institute is one the premier scientific research institutes of the country and is very strong in Drosophila research, given that there are five professors and 30 Ph.D. scholars who were using Drosophila to answer questions in developmental biology.

A total 57 talks and 240 posters on topics ranging from gametogenesis and stem cells, morphogenesis and mechanobiology, hormones and physiology, cellular and behavioural neurobiology, infection and immunity and ecology and evolution are scheduled for the conference.

One of the highlights of this conference is that we are explicitly encouraging undergraduates from various institutes of the world to participate in it. There is a pre-conference symposium called signals from the gut in collaboration with the National Centre for Cell Science, as well as a pre-conference microscopy workshop on super-resolution microscopy. This will feature microscopes from fluorescence imaging to super resolution imaging (50 nm resolution) which are vital for certain kinds of fly work, Prof. Dey said.

The last four editions of this conference took place in Taipei, Seoul, Beijing and Osaka.

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Pune to host fifth edition of global Drosophila conference - The Hindu

Fast Talk, ep. 91: Beyond the datatraining is about more than just the numbers – VeloNews

There is great value in keeping track of your training data, but if you focus only on the numbers, you are missing out on very critical aspects of your training.

Happy New Years, Fast Talk friends!

We are excited to be speeding into 2020 with our new company, Fast Labs, and continuing our partnership with VeloNews. For starters, and due to popular demand, Fast Talk will now be a weekly show. These new bi-monthly bonus episodes will be a bit shorter than the traditional Fast Talk episode, but in them youll find similar, detailed scientific physiology explanations, special interviews with your favorite pros, coaches, and experts, and well also regularly answer your questions.

To that end, thank you to the listeners who called and left us a voicemail over the holidays. Well be recording a special listener questions episode in the next week, so make sure to get your questions in as soon as you can. The number to call is 719-800-2112. If we can hear you loud and clear in the message, we may include the recording in the show.

Now, episode 91. The focus of this episode can be summarized in a single, powerful sentiment: There is great value in keeping track of your numbers, at analyzing the data youve gathered with your power meter, heart rate strap, or other device, but if all you do is focus on the numbers, and make them the end-goal themselves, you are missing out on very critical aspects of your training.

So, the underlying message of episode 91 is simple: Think of the numbers not as the target or the goal, but as a tool. What we will emphasize today are the many critical aspects of training and coaching that dont show up in the data.

Our primary guest is a very successful former professional cyclist turned coach Julie Young, whose road racing career stretched over a decade with teams including Saturn and Timex. She continues to race today at a very high level across multiple disciplines, and is currently part of the talented team behind the Kaiser Permanente Sports Medicine Endurance Lab in California.

Were also joined by co-owner of The cycling Gym, Coach Steve Neal, as well as Trek-Segafredos Ruth Winder, the reigning American national champion on the road.

Now, set your preferred analytics software aside for a minute. Lets focus on you, your brain, and this moment. Lets make you fast!

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Fast Talk, ep. 91: Beyond the datatraining is about more than just the numbers - VeloNews

UC Berkeley Researchers Restore Vision in Mice Through Gene Insertion – Gilmore Health News

Blind Mice Regain Vision After Gene Insertion in Trials

Loss of vision is one of the trickier health issues to deal with and is permanent in most cases. But research done at the University of California Berkeley suggests that people who have lost their eyesight might one day be able to see again.

Using a technique described as rather easy, researchers succeeded in helping mice regain their eyesight by inserting a gene into their eyes. The animals were able to detect motion and patterns as well as avoid obstacles within a month of receiving treatment.

Read Also: New Therapy Restores Vision Loss by Calming down Hyperactive Eye Cells

Around one in every 10 persons above the age of 55 suffers from age-related macular degeneration (AMD), according to estimates. Roughly 170 million people around the world have this disorder.

In addition, retinitis pigmentosa affects about 1.7 million people worldwide. Those who have this most-common form of inherited blindness typically become blind by age 40.

The best option currently available to people who have lost their vision is an electronic implant featuring a video camera. This is not only expensive but also does not deliver the finest results.

Researchers in the current study delivered a gene into the eyes of mice with the aid of an inactivated virus. This novel approach showed great promise of potentially being useful in the future to people with vision loss.

You would inject this virus into a persons eye and, a couple months later, theyd be seeing something, said Ehud Isacoff, a professor of molecular and cell biology at UC Berkeley. With neurodegenerative diseases of the retina, often all people try to do is halt or slow further degeneration. But something that restores an image in a few months it is an amazing thing to think about.

The research was reported in Nature Communications.

It is a thorny affair trying to rectify the genetic flaw that results in the degeneration of the retina. This is mainly because there are hundreds of genetic mutations involved. These mutations ensure that the vast majority of light-converting receptor cells in the retina die off.

Read Also: An Artificial Retina to Restore Sight Could Soon Become a Reality

Isacoff and John Flannery, also a professor of molecular and cell biology at UC Berkeley, had tried a variety of complex approaches over the years to restore vision with limited success. One of the techniques involved the insertion of genetically-engineered neurotransmitter receptors and light-sensitive switches into surviving eye cells.

Finally, the research team settled for a simpler approach of inserting a gene.

The scientists turned to the light-sensitive green cone opsins of photoreceptor cells. They delivered the gene for an opsin into the eye with the aid of an adeno-associated virus (AAV), which infects ganglion cells in the eye.

Usually, ganglion cells are not sensitive to light in blind people. But, in this study, they became light-sensitive after the virus moved the gene into them. The cells became able to send signals to the brain, which translates them into sight.

The researchers succeeded in making 90 percent of ganglion cells in mice sensitive to light in their trials. The animals performed comparatively well, visually, as their healthy counterparts as a result.

To the limits that we can test the mice, you cant tell the optogenetically-treated mices behavior from the normal mice without special equipment, said Flannery.

In mice that regained their eyesight, the vision lasted for their entire lifetime, the research team said.

It remains to be seen, however, whether the results can be replicated in humans. Scientists would require many more virus particles to make this possible because the human eye contains way more ganglion cells.

Isacoff and Flannery did admit that some people might doubt whether opsins can function outside their specialized photoreceptor cells. It is thought that opsins would not work elsewhere without transplanting the enzyme system responsible for recharging them.

Read Also: Age-related Close-up Vision Loss- How do I rid myself of reading glasses?

However, Isacoff theorized that an opsin would inevitably link to the retinal ganglion cells signaling system.

The researchers first tried rhodopsin in rods, being more light-sensitive than opsins in cones. This helped mice that were blind due to retinal degeneration to distinguish light from darkness. But rhodopsin failed in other aspects, including image recognition.

Finally, the team found that the green opsin in cones was 10 times more responsive than rhodopsin. It made the mice more sensitive that they could make out letters on an iPad.

The animals were able to make out and explore three-dimensional (3D) objects, a very common natural behavior. This means they could find their way around more easily.

The UC Berkeley team has fashioned a means of boosting viral delivery for possible use in humans. It aims to insert a light sensor into a high proportion of ganglion cells as done in the mice trials. The number of cells will be comparable to the incredibly high pixel count of a camera.

Isacoff and Flannery are trying to raise funds to assess the feasibility of this gene therapy in humans. They hope to be able to try it within three years in people who have lost their sight.

https://www.nature.com/articles/s41467-019-09124-x

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UC Berkeley Researchers Restore Vision in Mice Through Gene Insertion - Gilmore Health News

Smaller but Still Deadly: New Insights Into the Life of Teenage T. Rex – Gizmodo

A Tyrannosaurus rex skeleton on display at Washington Pavilions Kirby Science Discovery Center in Sioux Falls, San Diego. Image: AP

Tyrannosaurus rex was among the most fearsome carnivores to have ever lived, but this killer still had to endure an adolescent phase. Far from being awkward, however, these teenage titans managed to pack a tremendous punch prior to maturing into full-sized adults, as new research describes.

Unlike their lumbering yet undeniably powerful parents, teenage T. rex were fast and agile, equipped with teeth that were goodfor cutting, not crushing. These juveniles were able to hold their own in a perilous Cretaceous world, before entering into a growth spurt that brought them into adulthood and a new way of life.

Such are the findings of new research published in Scientific Reports, in which paleontologists analyzed a pair of mid-sized T. rex skeletons found during the early 2000s. Known as Jane and Petey, these fossils were unearthed in Carter County, Montana by paleontologists from the Burpee Museum of Natural History in Rockford, Illinois.

Jane and Petey were roughly half the size of an adultT. rex, which could grow to 12 meters (40 feet) in length. Fully mature T. rexwith their 1.5-meter-long (5-foot) headswere basically gigantic chomping machines who used their powerful jaws to crush prey. Needless to say, this impressive bone-snapping ability, at an estimated 8,000 pounds of force, didnt appear until later in life. The new research is important because it shows how juvenile T. rexes survived before they developed this capacity.

Importantly, the new research could also settle a debate caused by the discovery of Jane, Petey, and other apparently mid-sized T. rex skeletons. Some paleontologists argued that these fossils didnt belong to T. rex, but rather a pygmy genus of tyrannosaurid, which they dubbed Nanotyrannus. The evidence presented in the new paper, led by Holly Woodward from the Department of Anatomy and Cell Biology at the Oklahoma State University Center for Health Sciences, likely represents the death knell for the Nanotyrannus theory, which, to be fair, is a fringe theory to begin with.

The reason for this uncertainty and the ongoing debate, however, can be traced to the lack of juvenile dinosaur specimens.

Historically, many museums would collect the biggest, most impressive fossils of a dinosaur species for display and ignore the others, said Woodward in a press release. The problem is that those smaller fossils may be from younger animals. So, for a long while weve had large gaps in our understanding of how dinosaurs grew up, and T. rex is no exception.

Using a technique known as paleohistology, Woodward and her colleagues studied the microscopic structures embedded within the fossilized bones. Analysis of thin slices taken from the femur and tibia conveyed the specimens age, growth rate, and level of maturity.

To me, its always amazing to find that if you have something like a huge fossilized dinosaur bone, its fossilized on the microscopic level as well, said Woodward. And by comparing these fossilized microstructures to similar features found in modern bone, we know they provide clues to metabolism, growth rate, and age.

Results of the analysis showed that Jane and Petey were around 13 to 15 years old when they died, which means they had yet to experience their pre-adult growth spurt; T. rexes reached maturity at around 20 years of age, but they didnt live much beyond 30.

The new research also showed that T. rex exhibited rapid growth rates similar to modern birds and mammals, but their rate of growth was regulated by the availability of food. Variability in their growth, as evidenced by spacings the growth rings of their bones, suggests they grew quickly when food was in abundance and slowly when food was scarce.

This study helps us understand how T. rex went from a tiny baby to enormous adult, Steven Brusatte, a University of Edinburgh paleontologist not involved with the study, told Gizmodo in an email. Not only did they grow super fast, but they could change their growth rates depending on how much food and resources were available. This flexibility helped T. rex so utterly dominate its ecosystem.

And finally, the new research also shows that these pint-sized T. rexes were still a force to be reckoned with. They were sleek, slender, and fleet-footed and had wonderful knife-like teeth, said study co-author Scott Williams from the Museum of the Rockies in a press release. The new research suggests these animals probably dominated their ecosystems at all ages, he said.

Standing a bit taller than a large horse and measuring around 20 feet in length, teenage T. rexes mustve terrorized the Cretaceous landscape. It seems fitting that this iconic dinosaur, even before reaching full maturity, was already plenty deadly.

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