Gene editing breakthroughs that cured genetic diseases in 2019 – The Star Online

IN the summer of 2019, a mother in Nashville, Tennessee in the United States, with a seemingly incurable genetic disorder finally found an end to her suffering by editing her genome.

Victoria Grays recovery from sickle cell disease, which had caused her painful seizures, came in a year of breakthroughs in one of the hottest areas of medical research gene therapy.

I have hoped for a cure since I was about 11, the 34-year-old said.

Since I received the new cells, I have been able to enjoy more time with my family without worrying about pain or an out-of-the-blue emergency.

Over several weeks, Grays blood was drawn so that doctors could get to the cause of her illness stem cells from her bone marrow that were making deformed red blood cells.

The stem cells were sent to a Scottish laboratory, where their DNA was modified using Crispr/Cas9 pronounced Crisper a new tool informally known as a molecular scissors.

The genetically-edited cells were transfused back into Grays veins and bone marrow. A month later, she was producing normal blood cells.

Medics warn that caution is necessary, but theoretically, she has been cured.

This is one patient. This is early results. We need to see how it works out in other patients, said her doctor, Haydar Frangoul, at the Sarah Cannon Research Institute in Nashville.

But these results are really exciting.

In Germany, a 19-year-old woman was treated with a similar method for a different blood disease beta thalassemia.

She had previously needed 16 blood transfusions per year. Nine months later, she is completely free of that burden.

For decades, the DNA of living organisms such as corn and salmon has been modified. But Crispr, invented in 2012, made gene editing more widely accessible.

It is much simpler than preceding technology, cheaper and easy to use in small labs.

The technique has given new impetus to the perennial debate over the wisdom of humanity manipulating life itself.

Its all developing very quickly, said French geneticist Emmanuelle Charpentier, one of Crisprs inventors and the co-founder of Crispr Therapeutics, the biotech company conducting the clinical trials involving Gray and the German patient.

Gene cures

Crispr was the latest breakthrough in a year of great strides in gene therapy, a medical adventure that started three decades ago, when the first TV telethons were raising money for children with muscular dystrophy.

Scientists practising the technique insert a normal gene into cells containing a defective gene.

It does the work the original could not, such as making normal red blood cells in Grays case or making tumour-killing super white blood cells for a cancer patient.

Crispr goes even further: instead of adding a gene, the tool edits the genome itself.

After decades of research and clinical trials on a genetic fix to genetic disorders, 2019 saw a historic milestone: approval to bring to market the first gene therapies for a neuromuscular disease in the US and a blood disease in the European Union.

They join several other gene therapies bringing the total to eight approved in recent years to treat certain cancers and an inherited blindness.

Serge Braun, the scientific director of the French Muscular Dystrophy Association, sees 2019 as a turning point that will lead to a medical revolution.

Twenty-five, 30 years, thats the time it had to take, he said. It took a generation for gene therapy to become a reality. Now, its only going to go faster.

Just outside Washington, at the US National Institutes of Health (NIH), researchers are also celebrating a breakthrough period.

We have hit an inflection point, said US NIHs associate director for science policy Carrie Wolinetz.

These therapies are exorbitantly expensive, however, costing up to US$2 million (RM8.18 million) meaning patients face grueling negotiations with their insurance companies.

They also involve a complex regimen of procedures that are only available in wealthy countries.

Gray spent months in hospital getting blood drawn, undergoing chemotherapy, having edited stem cells reintroduced via transfusion and fighting a general infection.

You cannot do this in a community hospital close to home, said her doctor.

However, the number of approved gene therapies will increase to about 40 by 2022, according to Massachusetts Institute of Technology (MIT) researchers.

They will mostly target cancers and diseases that affect muscles, the eyes and the nervous system.

In this Oct 10, 2018, photo, He speaks during an interview at his laboratory in Shenzhen, China. The scientist was recently sentenced to three years in prison for practicing medicine illegally and fined 3 million yuan (RM1.76 million). AP

Bioterrorism potential

Another problem with Crispr is that its relative simplicity has triggered the imaginations of rogue practitioners who dont necessarily share the medical ethics of Western medicine.

In 2018 in China, scientist He Jiankui triggered an international scandal and his excommunication from the scientific community when he used Crispr to create what he called the first gene-edited humans.

The biophysicist said he had altered the DNA (deoxyribonucleic acid) of human embryos that became twin girls Lulu and Nana.

His goal was to create a mutation that would prevent the girls from contracting HIV (human immunodeficiency virus), even though there was no specific reason to put them through the process.

That technology is not safe, said Kiran Musunuru, a genetics professor at the University of Pennsylvania, explaining that the Crispr scissors often cut next to the targeted gene, causing unexpected mutations.

Its very easy to do if you dont care about the consequences, he added.

Despite the ethical pitfalls, restraint seems mainly to have prevailed so far.

The community is keeping a close eye on Russia, where biologist Denis Rebrikov has said he wants to use Crispr to help deaf parents have children without the disability.

There is also the temptation to genetically edit entire animal species, e.g. malaria-causing mosquitoes in Burkina Faso or mice hosting ticks that carry Lyme disease in the US.

The researchers in charge of those projects are advancing carefully however, fully aware of the unpredictability of chain reactions on the ecosystem.

Charpentier doesnt believe in the more dystopian scenarios predicted for gene therapy, including American biohackers injecting themselves with Crispr technology bought online.

Not everyone is a biologist or scientist, she said.

And the possibility of military hijacking to create soldier-killing viruses or bacteria that would ravage enemies crops?

Charpentier thinks that technology generally tends to be used for the better.

Im a bacteriologist -- weve been talking about bioterrorism for years, she said. Nothing has ever happened. AFP Relaxnews

More here:
Gene editing breakthroughs that cured genetic diseases in 2019 - The Star Online

Finding the right mix of genetics balancing and costs – High Plains Journal

In challenging times, beef producers are looking for an edge and genetics, nutrition and production are all part of the equation.

Finding the balance is the key for producers, according to Frank Goedeken, was one of the speakers at the first Cattle U and Trade Show, a High Plains Journal event July 29 to 30, at the United Wireless Arena in Dodge City, Kansas.

Goedeken has been a consulting nutritionist in the High Plains since 1989, including 15 years at Purina Mills and as an owner of Integrated Beef Consultants LLC. Priorities of his practice have been gain, conversion, cost of gain and out weight.

The challenge for producers continues to be to bring these advances together without compromising cattle health, properly growing and developing the cattle are required to reverse the trend of increased death loss and medicine costs.

As he visits with clients one of his goals is to not only look at the facility where the calves are located but also to help them envision the final product so the consumer has an enjoyable eating experience. He noted it all starts with the calves and all phases, from the cow-calf producer, to the backgrounder to the feeder all need to be on the same page.

If you talk to most feedyards and say, Youre going to bring in 100 calves that are being weaned on the truck? Hes not going to be very happy, Goedeken said. Why is that? Health is going to be an issue. So youre trying to improve the health of the cattle with good nutrition and good management.

At the same time producers need to keep tabs on feed costs and commodity prices, he said.

A cow-calf producer also needs to study the genetics of his herd and how the calves perform beyond the boundaries of the ranch, Goedeken said.

From his observations, Goedeken has noticed the comfort level of cattle is not always tied to feed. Good questions producers need to ask include do the cattle have the right pens and configurations? Should the producer do something different?

Sometimes the right environment for the cattle can make a big difference, too.

Have you ever noticed that cattle do not like to lay on bare dirt? You go out in your pasture, wheat stubble or whatever, he said. Very seldom would you see him or her lay on bare dirt. If you put some hay down or some straw out there theyd all be laying down. So thats kind of what we start with. Providing a comfortable environment is important.

Paying attention to nutrition is essential because of the life stages and physiological needs of the animal changes as they grow and mature and wrong decisions can even cause death to a young animal, he said.

Managing stress for the calf is also important, the consulting nutritionist said. A new environment can be a factor others may seem trite but are important, too, such as the water may taste different or the calfs mother is no longer with her calf. Goedeken said sometimes with all the stress, it can be wrongly assumed that all the calves are under stress. Then we run through, shoot, tag them and vaccinate.

He said, on the surface, it sounds like the right approach but it does not mean the situation was managed best for the cattle.

The more we stress the cattle the less likely they are to respond to challenges to their immune system, he said. They are less likely to respond to vaccines and the less likely they are to be healthy their entire life.

He also noted that timing of vaccines can make a difference and working with veterinarians is essential.

Nutritional stress occurs while trying to get those animals quickly up to speed to meet delivery needs but he says energy has to be balanced with health of the animals. In making a point he says distillers grain is an example in which feeders thought was a magic bullet but he says studies show the key remains balance in feeding nutrients.

A healthy animal means he is less likely to be stressed as a more stressed animal means more medication is needed, Goedeken said. Also, immune functions might become compromised and that can lead to unexpected death.

In looking at nutritional matters, he said striving to get to the right level of energy, protein and other nutrients in the diet does pay. Supplementing the diet with zinc can help producers because zinc is tied to muscle development and immune functions.

Stress negatively affects health and performance. As an industry, we need to pay more attention to that. When I grew up in the business I thought, Man, lets get all that stress over with, lets process them and lets get them into their pens? But it may not have been the right time to process those cattle based on what we talked about.

Healthier cattle perform better, he said, and that dynamic has not changed and much more information is available with studies to back it up.

Continue reading here:
Finding the right mix of genetics balancing and costs - High Plains Journal

‘Counting On’: Amy Duggar Just Started A Debate About Genetics On Her Instagram Page and It’s Hilarious – Showbiz Cheat Sheet

Well, its official, AmyDuggar doesnt want to be associated with the Duggar family any longer. Fanshave long suspected that cousin Amy has been slowly removing herself from theinner workings of the Duggar clan ever since MaryDuggar, the famed grandmother of 20 children, passed away unexpectedly inJune 2019. Now, Amy wants to make sure people know that her son, DaxtonRyan, isnt a Duggar, and its created quite the debate on Instagram.

Amy recently took to Instagram to share a photo of her youngson. The themed photo was all about ringing in the New Year, but followersseemed to want to discuss genetics and the Duggar name. One commentercomplimented Amy, claiming her son was beautiful because he was a Duggar. Apparently,Amy couldnt let that one go and reminded the commenter that while sheappreciated the sentiment her son, Daxton, was a King.

Amy married DillonKing in September 2015. Amy promptly changed her name to her husbands lastname. Their first child, Daxton Ryan, was born on Oct. 9, according to People.Since his birth, Amy has been postingalmost nonstop snapshots of the chubby baby, and while fans are absolutelyloving her pictures, they all seem to insist hes a Duggar. Amy wants everyoneto know he is not. Her most recent reminder kicked off a debate about geneticsand lineage.

The second Amy suggested her son was not a Duggar, thefamilys most prominent supporters came crawling out to comment. While manyinsist that he is a Duggar because Amy is a Duggar, their understanding of geneticsseems a little elementary. Yes, technically, Daxton is 25% Duggar because hismother, Amy, is 50% Duggar. Remember, Amy has a father, too. Daxton also shareshalf of his genetics with his father, Dillion. That means this child is not justa Duggar and not only a King.

While fans might be correct that he has Duggar blood, he carrieshis fathers surname, which appears to be what Amy was really trying to pointout. While several fans took it as a sign of disrespect, when you think about it,Duggar fans are actually the ones being disrespectful. Since Amy and Dillon havechosen to give their child the King name, fans should probably respect him aspart of that family.

Amy might be related to the Duggar clan through her mother,Deanna Duggar, but that doesnt mean she wants to be associated with their values.It has been clear, for years, that Amy was raised markedly different from her19 cousins. She was allowed to date, didnt need a chaperone, and while still aChristian, isnt a part of the ultra-conservative Christian ministry the Duggarfamily belongs to. She also was not homeschooled.

While Amy remains friendly with some of her cousins, shedoesnt seem to be particularly interested in being a part of the largerfamily. Back in November 2019, Amyinsisted she knew nothing about the rumored raids on the Duggar property,stating that she had no idea why people would think her aunt and uncle would tellher anything. Fans took the statement to mean that Amy isnt particularly closeto the supersized family.

Likely, shes not, to be honest. Her values dont jive withthe Duggars, and her husband recently investedin a whiskey lounge, a business that is undoubtedly not Duggar approved.Amy is also a business owner herself, meaning she works outside the home,another decision that is verboten in the Duggars social circle. Likely, Amyhas quietly been distancing herself from the large family for years, but a bombshellreason for the rift probably doesnt exist.

Go here to read the rest:
'Counting On': Amy Duggar Just Started A Debate About Genetics On Her Instagram Page and It's Hilarious - Showbiz Cheat Sheet

The supercells’ that cured an infants genetic illness – Jamaica Observer

'); } else { $(".fotorama-caption").addClass("remove_caption"); } }) .fotorama();

MCLEAN, United States (AFP) When a person's immune system is impaired by a genetic disease a bone marrow transplant can be a powerful therapeutic tool, but with a major downside during the first few months the recipient's defences against viruses are severely weakened. The slightest infection can lead to a hospital trip.

A still-experimental type of treatment known as T-cell therapy aims to assist during this vulnerable period the months during which the body is rebuilding its natural defences. After two decades of clinical trials, the technology has been refined and is being used to treat more and more patients, many of them children.

A boy named Johan is one of them.

Today he is a mischievous, smiling toddler, with a thick shock of light-brown hair, who never tires, playfully tormenting the family's puppy, Henry.

There is no sign of the three-year-long medical and emotional roller coaster ride he and his family, who live in an affluent Washington suburb, have been on.

The first traumatic surprise came with the results of a pregnancy test Johan was not planned.

That was a huge shock. I cried, said his mother, 39-year-old Maren Chamorro.

Risky procedure

She had known since childhood that she carried a gene that can be fatal in a child's first 10 years, chronic granulomatous disease (CGD).

Her brother died of it at the age of seven. The inexorable laws of genetics meant that Maren had a one in four chance of transmitting it to her child.

For their first children, she and her husband Ricardo had chosen invitro fertilisation, allowing the embryos to be genetically tested before implantation.

Their twins Thomas and Joanna were born both disease-free seven and a half years ago.

But in Johan's case, a post-birth genetic test quickly confirmed the worst: He had CGD.

After conferring with experts at Children's National Hospital in Washington, the couple took one of the most important decisions of their lives, Johan would receive a bone marrow transplant a risky procedure but one that would give him a chance of a cure.

Obviously, the fact that Maren had lost a sibling at a young age from the disease played a big role, Ricardo confided.

Bone marrow, the spongy tissue inside bones, serves as the body's factory for the production of blood cells both red and white.

His brother's immune system

Johan's white blood cells were incapable of fighting off bacteria and fungal infections. A simple bacterial infection, of negligible concern in a healthy child, could spread out of control in his young body.

Luckily, Johan's brother Thomas, six years old at the time, was a perfect match. In April 2018, doctors first cleansed Johan's marrow using chemotherapy. They then took a small amount of marrow from Thomas's hip bones using a long, thin needle.

From that sample they extracted supercells, as Thomas calls them stem cells, which they reinjected into Johan's veins. Those cells would eventually settle in his bone marrow and begin producing normal white blood cells.

The second step was preventive cell therapy, under an experimental programme led by immunologist Michael Keller at Children's National Hospital.

The part of the immune system that protects against bacteria can be rebuilt in only a matter of weeks; but for viruses, the natural process takes at least three months.

Hurdles remain

From Thomas's blood, doctors extracted specialised white blood cells T-cells that had already encountered six viruses.

Keller grew them for 10 days in an incubator, creating an army of hundreds of millions of those specialised T-cells. The result: A fluffy white substance contained in a small glass vial.

Those T-cells were then injected into Johan's veins, immediately conferring protection against the six viruses.

He has his brother's immune system, said Keller, an assistant professor at Children's National.

Johan's mother confirmed as much: Today, when Thomas and Johan catch a cold they have the same symptoms, and for nearly the same amount of time.

I think it's pretty cool to have immunity from your big brother, Maren Chamorro said.

This therapeutic approach boosting the body's immune system using cells from a donor or one's own genetically modified cells is known as immunotherapy.

Its main use so far has been against cancer, but Keller hopes it will soon become available against viruses for patients, like Johan, who suffer from depressed immune systems.

The chief obstacles to that happening are the complexity of the process and the costs, which can run to many thousands of dollars. These factors currently restrict the procedure to some 30 medical centres in the United States.

For Johan, a year and a half after his bone marrow transplant, everything points to a complete success.

It's neat to see him processing things, and especially play outside in the mud, his mother said.

You know, what a gift!

Her only concern now is the same as any mother would have that when her son does fall ill, others in the family might catch the same bug.

Now you can read the Jamaica Observer ePaper anytime, anywhere. The Jamaica Observer ePaper is available to you at home or at work, and is the same edition as the printed copy available at http://bit.ly/epaperlive

Read the rest here:
The supercells' that cured an infants genetic illness - Jamaica Observer

Opinion: Why Republicans will stick with Trump in 2020 – Los Angeles Times

Recently, a close friend and fellow Republican told me he was personally shocked at what the evangelicals have been willing to stomach from Donald Trump. Im not shocked at all.

My friends sentiment a variation on the empty if Obama had done this, Republicans wouldve impeached him has become a staple of Democrats and Never Trumpers. Are you ready to turn on him yet? Republicans are asked over and over.

No one ever says yes. The Republicans who make a living hating Trump today hated him before he was elected. The rest of the party remains solidly behind him. The reason for that, as we enter this election year, is less granular than feeling happy or sad about a specific presidential behavior. Rather, it has to do with the general direction of the nation: Trump and whoever the Democrats nominate represent such fundamentally different directions for our country that it is almost unthinkable for a Republican voter to be seriously torn.

Imagine standing at a train station in Louisville, Ky., staring at the schedule board. You want to get to Los Angeles, and you have a choice of two trains one headed to San Diego and one headed to Washington, D.C. Neither gets you exactly where youre heading, but theres really only one choice as the alternative to San Diego is to go precisely the wrong way.

Even if the San Diego train sometimes hits bumpy tracks, and the conductor comes on the PA and says crude and dumb stuff, and there are people on the train you really wish would get off: It is still taking you basically where you want to go.

To the average Republican voter, like the passenger on that train, the destination is what matters.

I tried to explain this to my friend. I told him that, for Christian conservatives, the choices are Trump versus people who prefer full-term abortions and believe that that our country should functionally have no borders. To vote against Trump is to vote for a party that fundamentally believes Republicans are deplorable and racist.

The decision isnt hard.

But the porn stars! The crudeness! The immorality! my friend says.

To a Christian conservative voter, the individual behavior of an imperfect human pales against the importance of protecting human life. If the imperfect president appoints pro-life judges and takes your values into account when making policy, you dont worry so much about one sinners struggles with morality. You just pray for him, while also giving thanks for all he does to advance your cause.

Choosing any of the Democrats running for president isnt simply boarding a train headed in a slightly different direction, or one going the same way with a nicer conductor. It means completely turning around. For goodness sakes, Elizabeth Warren and Joe Biden have both proposed plans that would spend taxpayer dollars on gender assignment surgery!

And thats what has been so illuminating about this Democratic primary race: Because of their extreme tilt to the left, none of these candidates have a prayer of peeling off a statistically significant number of Republican voters. No matter what the Never Trumpers in your Twitter feed tell you, Trump win or lose will have the support of more than 90% of his party.

Some people used to argue that the two parties are basically the same. It wasnt true then, and its especially not true now. Most of Trumps governance has been what youd expect from any Republican president (conservative judges, lower taxes, deregulation, an embrace of pro-life policies), and the wild extremism of his would-be opponents is causing some center-right voters who were lukewarm on Trump three years ago to feel closer to him than ever before.

The exception to that is the cohort of suburban women who clearly abandoned the Republicans in the 2018 midterm and strongly disapprove of Trump now. But will losing them be enough to derail the Trump train?

I consulted the impeachment polling aggregator on Nate Silvers FiveThirtyEight website on Dec. 29, and it said that 48% of Americans prefer impeachment and removal versus 46% who did not. As has been true for three years, the polls say men basically want Trump and women basically dont.

Impeachment has become a political Rorschach test, and Trump might easily win reelection with a two-point deficit in the popular vote. The question isnt how Republicans can still vote for Trump, but how the Democrats became so radicalized as to present no viable alternative to huge swaths of nonurban America.

Scott Jennings is a former advisor to President George W. Bush and Senate Majority Leader Mitch McConnell and a CNN contributor. He is a contributing writer to Opinion. Twitter: @ScottJenningsKY.

See the article here:
Opinion: Why Republicans will stick with Trump in 2020 - Los Angeles Times

Alexandria mayor names acting chief as ousted chief’s backers call for support – The Town Talk

Alexandria Mayor Jeff Hall has named an acting police chief as opposition to his administration placing Jerrod King on leave got louder with his supporters calling for citizens to push back.

Hall, in a release sent out Sunday, named Alexandria Police Department Assistant Chief Farrell Gaspard as the acting chief.

A message on an electronic billboard near the Jackson Street and Versailles Boulevard intersection shows support for Chief Jerrod King, who was placed on leave Friday.(Photo: Melissa Gregory/The Town Talk)

More: City: Alexandria Police Department Chief Jerrod King placed on leave

More: Alexandria police: Thursday explosion outside former bar was an extortion attempt

More: Police, FBI search Alexandria gas station as part of 'active investigation'

Hall stated he thought Gaspard, a 32-year veteran with the department and Mansura native, would ""do an outstanding job in this role.

King, named chief in May 2018 by former Mayor Jacques Roy, was placed on administrative leave on Friday. No reason was given, and a city spokesman said itcouldn't be discussed since it was a personnel matter.

Acting Alexandria Police Chief Farrell Gaspard(Photo: Courtesy/city of Alexandria)

Just days before, on New Year's Eve, had King posted a message on his personal Facebook page to the department's officers. He wrote that the past year had been exciting and challenging.

"Together, we have faced critical issues ranging from manpower concerns, budgetary constraints, and concerns of financial compensation for you, to what sometimes seems to be a continual display of the worst in human behavior," he wrote. "Despite all of the obstacles and issues that have arisen along with facing the evil that all of you confront on a daily basis you have remained true to our departmental values of Service to Others, Honor, Integrity, Excellence, Loyalty, and Dedication."

The message also wished his officers and their families peace, prosperity and happiness for 2020.

"It has been my distinct honor and absolute privilege to serve as your Chief this past year. None of us know what tomorrow may hold but I want to assure you that I am and will always be extremely grateful to each of you, the men and women of this department, and to your families for allowing me to serve as your Chief."

King's supporters on Saturday unveiled a Facebook page, AEX4King, asking residents to show their support. They called upon residents to attend Tuesday's Alexandria City Council meeting to support King.

The page has garnered more than 1,200 likes since its debut on Saturday.

Supporters also paid to post a message of support on at least one electronic billboard on Jackson Street.

Read or Share this story: https://www.thetowntalk.com/story/news/2020/01/05/alexandria-mayor-names-acting-chief-ousted-chiefs-backers-call-support/2819292001/

See the article here:
Alexandria mayor names acting chief as ousted chief's backers call for support - The Town Talk

Should Tesla Take The Initiative To Better Monitor And Manage Driver Behavior With Autopilot? – Forbes

A video call while a car is driven by an autopilot. Is there a need to couple driver monitoring with ... [+] collaborative automation?

By any account, Teslas Autopilot feature has come a long way since being released to consumers through an Over-The-Air (OTA) update just over 4 years ago. At inception, it was at best an incredibly sophisticated bootstrapped system based upon a Mobileye sensing platform and limited processing capabilities. With Teslas newer computing and data platforms, Autopilot is clearly one of the worlds more complex and impressive applications of a learning based Artificial Intelligence (AI) system.

The safety of Autopilot continues to be questioned by experts worldwide. A recent letter from Senator Markey to Elon Musk adds to an already heated conversation. In a post earlier this year on the Tesla automation strategy, I raised the question of whether it is appropriate for consumers to be used as test subjects, the need for a well validated measure of risk associated with the use of Autopilot, and the need for camera-based driver monitoring to manage inattention. In the months since, visuals in the media of drivers falling asleep, engrossed in non-driving activities, and otherwise participating in inattentive driving continue to appear. Seemly random, but realistically predictable, crashes keep happening that might be preventable with camera-based driver monitoring and driver management.

The reason crashes are predictable is that humans have long been known to be poor overseers of highly automated systems. When a supervisor feels that the automation is trustable, the irony is that there will be an increase in the number of system failures that are not mitigated correctly by a human supervisor. It simply becomes increasingly difficult to sustain attention as automation becomes more reliable. There is a painful history in transportation safety showing this. Recently, the National Transportation Safety Board (NTSB) detailed these types of failures in investigations of several Autopilot crashes and the tragic 2018 Uber fatality.

Perhaps paradoxically, it could be argued that with the explosive use of Autopilot, we would expect to see more crashes. However, the work from the late Raja Parasuraman and his students would suggest that imperfect automation (like Autopilot) keeps many users from becoming too complacent. In essence, its possible that the failure of a few individuals to appropriately oversee and collaborate with the automation is mixed with more responsible use by many.

This is not a new phenomenon for automotive engineers. It has long been known that it is difficult to engineer for all. Some drivers choose to speed, pick-up their phones, and be otherwise irresponsible with respect to other drivers with which they share the road. Are close-calls and crashes with Autopilot really more frequent than other cases of attention failures? Or are they just more easily associated with the evolution of a new and perhaps transformative (and perhaps over marketed) technology? Over the coming years there will likely be many efforts to better understand, and arguments around answering, these formidable questions. One clear difference from the introduction of previous generations of automotive systems is that todays social media driven society is helping to highlight problematic events.

The images and video that accompany todays social posts have increasingly brought what was once largely hidden from public view into the limelight. This naturally presses consumers, safety advocates, regulators and even politicians into a position of judging the social ethics of how technologies are implemented.

Given this new reality, Senator Markys letter to Mr. Musk questioning if Tesla is tracking or monitoring online videos to learn about inappropriate use of the Autopilot, is right on track. Something else to consider is that Tesla Model 3s are equipped with a cabin camera. Might Tesla use this sensor, and a fraction of their technological image processing prowess, to better gauge the state of drivers? Even a rudimentary driver monitoring system might be able to detect an outright inattentive driver asleep at the wheel or head down for seconds on end.

Manufacturers such as GM and BMW have introduced camera-based driver monitoring and management systems with the launch of their collaborative driving systems (i.e., SAE L2). One has to suspect other manufacturers will follow this seemingly reasonable route to market, bridging the time till automated systems that do not depend on attentive human back-up are truly available.

Just as outliers may be responsible for the majority of risky behavior associated with Autopilot, might Tesla be passively accepting undue risk compared to the rest of the market? Growing evidence suggests that Autopilot is placing drivers, and perhaps the automotive industry, in a precarious position. The aviation industry has long known that one airlines accident impacts trust in all airlines.

With a call to reinvent driving through the greater use of automation, is it time for the automotive industry to collaborate to increase the likelihood that the introduction and refinement of these technological approaches to making driving safer in the years ahead will have the greatest potential to succeed?

Following efforts in Europe, and using a framework similar to the NHTSA-IIHS collaborative industry agreement on AEB, could manufacturers and the government come together to take another step forward in safety by collaboratively agreeing to install camera-based driver monitoring systems to work alongside collaborative driving features?

Some might argue that a detailed, performance-based standard for systems is needed. However, starting with a fairly broad and open concept may be a more realistic starting point, and a Federal Motor Vehicle Safety Standard (FMVSS) could be more easily justified as experience is gained and the cost / benefit justification of a standard emerges. Working together to develop guardrails around the deployment and testing of automation on public roads might be the most important step to accelerate the adoption of potentially lifesaving automated vehicle technologies.

Originally posted here:
Should Tesla Take The Initiative To Better Monitor And Manage Driver Behavior With Autopilot? - Forbes

Sticking to New Year’s resolutions: Turn goals into habits – Inverse

As the new decade begins, you probably came up with a few resolutions worthy of a decade where humans will push the limits of space exploration and A.I. will become less of an abstract and more of a central part of human life. If you made a New Years resolution, youre also probably aware of the pessimistic statistics that surround them.

Humans have been making New Years resolutions for about 4,000 years, when the Babylonians took an opportunity to repay their debts or return items theyd borrowed during a festival called Akitu. Despite millennia of vowing to be better, humans are not any better at keeping our resolutions than we were 4,000 years ago. Research done in the 80s found that only 43 percent of people stuck to their resolutions after three months.

A version of this article first appeared as the Strategy. Sign up for free to receive it weekly.

That bleak history doesnt speak to the futility of resolutions; they just show how hard it is to change our behavior. Humans tend to prefer default options, whatever they may be This is sometimes called status quo bias.

Behavior change is at the heart of basically any New Years resolution you have, which is one of the reasons keeping them feels so hard. To combat that, you have to learn to take a resolution and turn it into a habit you dont have to think twice about.

One expert in habit formation tells Inverse theres no way to hasten the process, but there are ways to set yourself up for success.

Phillippa Lally is a senior research fellow at University College Londons Department of Behavioral Science and Health. In 2009, she published a paper intended to show just how long it took 96 people to form a new eating, drinking, or exercise habit from running for 15 minutes before dinner to drinking a glass of water after breakfast.

That paper, which has been cited over 1,000 times in the intervening 11 years, found that the average amount of time it took for these goals to become habits was 66 days.

Lally tells Inverse that 66 days isnt the magic bullet for habit formation as it appears to be. She found that some people were able to form habits as quickly as 18 days, whereas for others it took as long as 254 days. Instead, the most important thing her study identified is that habit formation follows an asymptotic curve:

This curve shows the relationship between doing your chosen activity and the automaticity of that activity which is basically when you start to feel an impulse to perform that activity. (Her team used surveys that evaluated automaticity on a scale of 0 to 42.) If you look at the early days of the experiment, you can see that there are big jumps in automaticity. But over time those jumps get smaller and smaller and the curve starts to plateau.

With each subsequent repetition, the increase is a bit less, until you reach a point at which the behavior has reached its peak of automaticity. And with each new repetition, the automaticity you experience when you enter the situation remains stable, Lally says.

Once you hit that peak, the automaticity gains start to plateau. Thats the point at which your resolution has transformed into a habit.

You can consider the time it takes people to reach this plateau to represent the time it takes their habit to form, she says.

That 66 days is just a ballpark measure to give you an idea of how long the road to habit formation actually is. To get to that plateau, her advice is to try to be as consistent as you can.

Inevitably, you will miss an opportunity to perform your habit of choice. If youve decided to run every morning, youll sleep in or take a well-deserved day off. Fortunately, Lally says this wont set you back very much. Missing just one day of an activity reduced a persons automaticity score by .29, a very small decrease that didnt have any major consequences in the long term.

In the paper, the team points out that missing larger chunks of time, like a week, can significantly derail habit formation. So, again, theres no shortcut for consistency.

Finally, take heart in the fact that you make the biggest automaticity gains right out of the gate. That means you can use these early days of January, when youre feeling newly inspired to pursue new goals. Every time you actually follow through on your resolution, youre putting money in your automaticity bank and setting yourself up for success once the new year loses its shine.

Lally says that the best way to apply her work to a New Years resolution is to frame that goal in a specific way. Once you decide what your goal is, you need to find a cue for that goal.

In her study, people were told to bake that cue into their goals. They pledged to do 50 sit-ups after my morning coffee or go for a run before dinner. That time element is a situational cue that should trigger that behavior.

The cue doesnt have to be time-oriented, but it does have to be recognizable enough that it becomes associated with the desired behavior in your mind.

It is crucial that there is a cue for the behavior. Otherwise, the behavior could be performed in various situations and a habit wont form, says Lally.

From there, she recommends that you follow this formula to write down your goals:

In situation X, I will perform behavior Y.

This type of structure, says Lally, is called an implementation intention. Instead of pledging to go to the gym more, frame it like this: After work on Tuesday, I will go to the gym.

Then, repeat the desired behavior as many times as possible when you get into situation X. That way youll start working your way along the asymptotic curve and move towards the plateau of automaticity.

Though Lally describes herself as quite a routine person, shes taught her daughter about implementation intentions by asking her to repeat her goals aloud using the in situation X, I will perform behavior Y format:

If I ask her to remind me of something later, she will make a plan and repeat it aloud three times. For example, When we get home, I will remind mummy to put the washing on.

Talking out loud to yourself or writing down your goals is a method that expert musicians also use to learn new skills. In this case, it can help you pursue the automaticity that turns a resolution into a habit.

A version of this article first appeared as the Strategy newsletter. Sign up for free to receive it weekly.

Read the original here:
Sticking to New Year's resolutions: Turn goals into habits - Inverse

How Economists Tricked Us Into Thinking Capitalism Works – Truthout

These days, it seems like someone is always trying to privatize something. One day its the Trump administration contemplating the privatization of the Department of Veterans Affairs. The next its the Tories looking to sell off the U.K.s National Health Service, or economists promoting market-based solutions to the climate crisis. In this age of neoliberalism, the rallying cry for politicians and economists alike is always for More privatization! More markets! Sell it all off to the private sector!

Of course, much of the time this faith in the market is used as a cover by those looking to simply make a profit or by the politicians representing their interests. But this is not always the case. There are many who actually believe, wholeheartedly, that markets are the most efficient and even the most ethical way to run a society. And because this is the worldview that is taught in the vast majority of economics departments throughout the world, its not surprising that this is the dominant worldview among those in power.

Its an ideology that was carefully crafted during the time of the early Western economists like Adam Smith and David Ricardo. Homo sapiens are actually Homo economicus, the theory goes: selfish, competitive, rational agents who are all constantly seeking to efficiently maximize their own personal well-being.

Get reliable, independent news and commentary delivered to your inbox every day.

No need to despair, however, because economists have figured out that these inherent traits can actually be utilized for good, through a social relation known as the market. By its nature, the market encourages competition and efficiency, and thus, by relying on the self-maximizing behavior of individuals, market capitalism is the only economic system that truly accepts human nature for what it is. And in fact, its the only system uniquely situated to actually channel this nature into a net positive outcome for society.

How does this all work? Well, when they are free to make choices that maximize their own interests, people in a market system negotiate on a price and quantity of a product or service until a sort of equilibrium is established. Its a natural process of compromise that leaves everyone satisfied and also leads to an efficient way of producing and distributing goods and services. Everyone wins. And, the theory goes, it just so happens that the process aligns perfectly with human nature. Its a fascinating theory. The only thing is, its completely wrong.

The foundation of this theory relies on an assumption about human nature that has been discredited over and over by research across multiple scientific disciplines. It turns out that Homo economicus is a fairytale, an outdated misconception, a gross distortion of reality. Yet, it still serves as the theoretical foundation of our entire economic system.

Studies have determined that the Homo economicus personality is an extremely rare one. Instead, most humans are marked by a deep capacity for reciprocity, cooperation and selflessness. For example, research shows that by 14 months of age, children are already beginning to help each other by handing over objects that others are unsuccessfully reaching for. This empathic behavior only increases as children grow older and begin to share things that they value with others and even object to other peoples violation of social norms.

These are all early signs of prosociality behavior that is marked by an intent to help or benefit others. And importantly, this behavior is motivated by a genuine concern for others and not by selfishness.

Evolutionary biologists have also largely debunked the theory of Homo economicus. Researchers like David Sloan Wilson and others have determined that more prosocial groups will robustly outcompete less prosocial groups, meaning that prosociality was an advantageous trait when it came to the natural selection of early humans. And these theories are not new. Over a century ago, the anarchist theorist Peter Kropotkin wrote convincingly on how the survival of our species has depended more on cooperation than on the heroic efforts of isolated individuals. It certainly is difficult imagining an early human taking down a woolly mammoth without engaging in highly coordinated prosocial behavior. How else could the human species evolve to dominate the globe if not by cooperating with one another to overcome the many challenges our species faced?

Another place where we see the myth of Homo economicus debunked is in the research that comes out of post-disaster communities. In her landmark book, A Paradise Built in Hell, Rebecca Solnit presents a thesis arguing that humans have an innate capacity toward collectivism and that these traits tend to reveal themselves most strongly in community response to disasters. Far from resorting to antisocial behavior after a disaster (a myth which the media tend to elevate), Solnits book outlines enumerable instances where communities demonstrate prosocial behaviors like cooperation, solidarity, sacrifice and generosity instead.

In the wake of an earthquake, a bombing, or a major storm, most people are altruistic, urgently engaged in caring for themselves and those around them, strangers and neighbors as well as friends and loved ones, Solnit writes. Decades of meticulous sociological research on behavior in disasters, from the bombings of World War II to floods, tornadoes, earthquakes, and storms across the continent and around the world, have demonstrated this.

Yet, despite the overwhelming evidence contradicting it, weve come to accept Homo economicus as the truth. Perhaps not always consciously, but it haunts our dreams, our imagination. It confines our sense of possibility and imposes boundaries as arbitrary as those that carve up ecosystems and communities into nation-states.

Market capitalism has been imposed onto us, often at the point of a gun, and as a result, weve been forced to internalize the idea that we are a selfish, competitive and greedy species. Well, thats just human nature, well acquiesce when we hear about the profiteering of pharmaceutical companies or the greed of investment bankers. But the thing this, thats not human nature its just what weve been coerced into thinking by an unfeeling economic system that dominates every facet of our life. And in many ways, Homo economicus is a self-fulfilling prophecy.

Its been demonstrated that studying economics actually makes you more selfish. Studies have shown that economics students are much less likely than other students to donate money that was given to them into a common pool; that they are more likely to freeride and are also more likely to defect than to cooperate; that they are more likely to participate in deception for personal gain; and even that they are more likely than their peers to rate greed as generally good, correct and moral.

And its not just students: economics professors give less money to charity than professors in other fields including history, philosophy, education, psychology, sociology, anthropology, literature, physics, chemistry and biology.

When faced with the overwhelming evidence that Homo economicus and thus the whole neoclassical economic project is nonsense, the defenders of the status quo tend to rely on another myth: that there is no alternative. Margaret Thatcher famously uttered those words over 30 years ago, paving the way for an age of neoliberalism that has seen the dismantling of the social safety net, the stagnation of wages and the rise of extreme inequality.

But the thing is, there are alternative ways of organizing society that reflect the human capacity for reciprocity, selflessness and cooperation. The worker cooperative model promotes equity and democracy by giving workers ownership and control over their workplaces. It does so in a way that not only aligns with our inherently human traits, but in a way which has been shown to be more efficient and productive than the traditional workplace models.

There is also the commons model that reflects how communities organized themselves for thousands of years before they were torn off their land in the enclosure acts of 17th-century England. The commons are a way of organizing production and distribution where resources are held in common and are accessible to every member of society to be managed collectively for the benefit of all.

In fact, the political economist Eleanor Ostrom actually won the Nobel Prize in Economics in 2009 for disproving the long-held belief known as the tragedy of the commons, a theory which held that resources held in common by communities would naturally be overused and depleted. Ostroms work demonstrated that this assumption is false, and that it is in fact very possible for resources to be managed collectively without privatization.

There are many ways that community resources can be collectivized instead of privatized, from land trusts that take land off of the market to policy proposals like Medicare for All, which represents a major shift in how we view our collective responsibility when it comes to health care, or the Green New Deal, which recognizes our collective responsibility to prioritize climate justice in the fight against climate change.

The alternatives to market capitalism are out there and the thing is, they actually align much more closely to the natural human tendencies toward reciprocity and sharing. The theories behind modern economics have left us with a burning planet and with skyrocketing inequality its time to put them to rest.

And whether economists and politicians choose to accept it or not, the days of Homo economicus are limited, because a society based off of a lie cannot go on indefinitely.

More:
How Economists Tricked Us Into Thinking Capitalism Works - Truthout

Smokers with COPD Show a Shift in Energy and Nitrogen Metabolism at Re | COPD – Dove Medical Press

Olaf Holz,1,* David S DeLuca,2,* Stefan Roepcke,3 Thomas Illig,2 Klaus M Weinberger,46 Christian Schudt,7 Jens M Hohlfeld1,2

1Fraunhofer ITEM, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover, Germany; 2Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research, Hannover, Germany; 3Department of Biomarker Development, Takeda Pharmaceuticals International GmbH, Zrich, Switzerland; 4Biocrates Life Sciences AG, Innsbruck, Austria; 5Research Group for Clinical Bioinformatics, Private University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria; 6sAnalytiCo Ltd, Belfast, Ireland; 7Department of Biochemistry, ALTANA, Konstanz, Germany

*These authors contributed equally to this work

Correspondence: Olaf HolzDepartment of Clinical Airway Research, Fraunhofer ITEM, Hannover 30625, GermanyTel +49-511-5350-8141Fax +49-511-5350-8250Email olaf.holz@item.fraunhofer.de

Purpose: There is an ongoing demand for easily accessible biomarkers that reflect the physiological and pathophysiological mechanisms of COPD. To test if an exercise challenge could help to identify clinically relevant metabolic biomarkers in COPD.Patients and Methods: We performed two constant-load exercise challenges separated by 4 weeks including smokers with COPD (n=23/19) and sex- and age-matched healthy smokers (n=23/20). Two hours after a standardized meal venous blood samples were obtained before, 5 mins after the start, at the end of submaximal exercise, and following a recovery of 20 mins. Data analysis was performed using mixed- effects model, with the metabolite level as a function of disease, time point and interaction terms and using each individuals resting level as reference.Results: Exercise duration was longer in healthy smokers but lactate levels were comparable between groups at all four time points. Glucose levels were increased in COPD. Glutamine was lower, while glutamate and arginine were higher in COPD. Branched-chain amino acids showed a stronger decline during exercise in healthy smokers. Carnitine and the acyl-carnitines C16 and C18:1 were increased in COPD. These metabolite levels and changes were reproducible in the second challenge.Conclusion: Higher serum glucose, evidence for impaired utilization of amino acids during exercise and a shift of energy metabolism to enhanced consumption of lipids could be early signs for a developing metabolic syndrome in COPD. In COPD patients, deviations of energy and nitrogen metabolism are amplified by an exercise challenge.

Keywords: targeted metabolomics, biomarker, airway inflammation

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Follow this link:
Smokers with COPD Show a Shift in Energy and Nitrogen Metabolism at Re | COPD - Dove Medical Press