BrainStorm Cell Therapeutics to Present at the 2020 Biotech Showcase and 3rd Annual Neuroscience Innovation Forum at JPM Week – Yahoo Finance

NEW YORK, Jan. 07, 2020 (GLOBE NEWSWIRE) -- BrainStorm Cell Therapeutics Inc. (BCLI), a leading developer of adult stem cell therapeutics for neurodegenerative diseases, announced today that Chaim Lebovits, President and Chief Executive Officer, will provide a corporate overview at the 2020 Biotech Showcase, being held on January 13-15, 2020 at the Hilton San Francisco Union Square in San Francisco, California.

Mr. Lebovits will also present at the 3rd Annual Neuroscience Innovation Forum, taking place on January 12, 2020, at the Marines Memorial Club in San Francisco. Additionally, Ralph Kern M.D., MHSc, BrainStorms Chief Operating Officer and Chief Medical Officer, will participate on aRare & Orphan Diseases Panel.

2020 Biotech Showcase

Details

Date:

Monday, January 13, 2020

Time:

11:00 am Pacific Time

Location:

Hilton San Francisco Union Square, Hilton/Yosemite A, Ballroom Level

Presenter:

Chaim Lebovits, CEO

Webcast:

https://bit.ly/37EfFfC

Rare & Orphan Disease Panel:

Details

Date:

Sunday, January 12, 2020

Time:

10:45 am Pacific Time

Location:

Marines Memorial Club, SF

Presenter:

Dr. Ralph Kern, COO & CMO

Meetings

BrainStorms senior management will also be hosting institutional investor and partnering meetings at the 2020 Biotech Showcase conference (https://goo.gl/SGFm62). Please use the Investor contact information provided below to schedule a meeting.

About NurOwn

NurOwn (autologous MSC-NTF cells) represent a promising investigational approach to targeting disease pathways important in neurodegenerative disorders. MSC-NTF cells are produced from autologous, bone marrow-derived mesenchymal stem cells (MSCs) that have been expanded and differentiated ex vivo. MSCs are converted into MSC-NTF cells by growing them under patented conditions that induce the cells to secrete high levels of neurotrophic factors. Autologous MSC-NTF cells can effectively deliver multiple NTFs and immunomodulatory cytokines directly to the site of damage to elicit a desired biological effect and ultimately slow or stabilize disease progression. NurOwn is currently being evaluated in a Phase 3 ALS randomized placebo-controlled trial and in a Phase 2 open-label multicenter trial in Progressive MS.

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About BrainStorm Cell Therapeutics Inc.

BrainStorm Cell Therapeutics Inc. is a leading developer of innovative autologous adult stem cell therapeutics for debilitating neurodegenerative diseases. The Company holds the rights to clinical development and commercialization of the NurOwn technology platform used to produce autologous MSC-NTF cells through an exclusive, worldwide licensing agreement. Autologous MSC-NTF cells have received Orphan Drug status designation from the U.S. Food and Drug Administration (U.S. FDA) and the European Medicines Agency (EMA) in ALS. BrainStorm has fully enrolled a Phase 3 pivotal trial in ALS (NCT03280056), investigating repeat-administration of autologous MSC-NTF cells at six sites in the U.S., supported by a grant from the California Institute for Regenerative Medicine (CIRM CLIN2-0989). The pivotal study is intended to support a filing for U.S. FDA approval of autologous MSC-NTF cells in ALS. For more information, visit BrainStorm's website at http://www.brainstorm-cell.com.

Safe-Harbor Statement

Statements in this announcement other than historical data and information, including statements regarding future clinical trial enrollment and data, constitute "forward-looking statements" and involve risks and uncertainties that could causeBrainStorm Cell Therapeutics Inc.'sactual results to differ materially from those stated or implied by such forward-looking statements. Terms and phrases such as "may", "should", "would", "could", "will", "expect", "likely", "believe", "plan", "estimate", "predict", "potential", and similar terms and phrases are intended to identify these forward-looking statements. The potential risks and uncertainties include, without limitation, BrainStorms need to raise additional capital, BrainStorms ability to continue as a going concern, regulatory approval of BrainStorms NurOwn treatment candidate, the success of BrainStorms product development programs and research, regulatory and personnel issues, development of a global market for our services, the ability to secure and maintain research institutions to conduct our clinical trials, the ability to generate significant revenue, the ability of BrainStorms NurOwn treatment candidate to achieve broad acceptance as a treatment option for ALS or other neurodegenerative diseases, BrainStorms ability to manufacture and commercialize the NurOwn treatment candidate, obtaining patents that provide meaningful protection, competition and market developments, BrainStorms ability to protect our intellectual property from infringement by third parties, heath reform legislation, demand for our services, currency exchange rates and product liability claims and litigation,; and other factors detailed in BrainStorm's annual report on Form 10-K and quarterly reports on Form 10-Q available athttp://www.sec.gov. These factors should be considered carefully, and readers should not place undue reliance on BrainStorm's forward-looking statements. The forward-looking statements contained in this press release are based on the beliefs, expectations and opinions of management as of the date of this press release. We do not assume any obligation to update forward-looking statements to reflect actual results or assumptions if circumstances or management's beliefs, expectations or opinions should change, unless otherwise required by law. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance or achievements.

CONTACTS

Corporate:Uri YablonkaChief Business OfficerBrainStorm Cell Therapeutics Inc.Phone: 646-666-3188uri@brainstorm-cell.com

Media:Sean LeousWestwicke/ICR PRPhone: +1.646.677.1839sean.leous@icrinc.com

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BrainStorm Cell Therapeutics to Present at the 2020 Biotech Showcase and 3rd Annual Neuroscience Innovation Forum at JPM Week - Yahoo Finance

Harnessing biology and technology to develop much-needed treatments for depression – News-Medical.net

New research into the biology of depression, along with new and evolving technologies, provides the basis for developing the next generation of treatments for major depressive disorder (MDD), according to the special January/February issue of Harvard Review of Psychiatry. The journal is published in the Lippincott portfolio by Wolters Kluwer.

By embracing a multifactorial understanding of MDD, by attending carefully to the sex difference in its prevalence and manifestation, and by harnessing new technology, we should be increasingly able to prevent and treat depression."

Guest Editor Diego A. Pizzagalli, PhD, of McLean Hospital, Belmont, Mass.

Contributed by international experts, the five articles in the special issue provide updates on neuroscience and technology that may inform the development of much-needed treatments for depression. Topics include:

Gender Differences in Depression. After age 12, MDD is twice as common in girls compared to boys. Studies have yielded insights into the affective, biological, and cognitive factors contributing to this gender difference - for example, negative emotionality, pubertal hormones, and negative cognitive style. While each factor has a relatively small effect on risk, past and present stressors amplify their impact. Continued research may lead to evidence-based treatments that better take into account the particular needs and circumstances of girls and women.

Neuroscience and Behavioral Interventions. "Neuroscience-based augmentation strategies" are being pursued to address two key aspects of depression: anhedonia (loss of interest in pleasurable activities) and cognitive deficits/biases. An approach called Positive Affect Treatment targets issues related to motivation, reward attainment, and reward learning. In an initial clinical trial, this approach showed benefits including decreases in depression symptoms, suicidal thoughts, and stress.

Role of the Microbiome. Evidence suggests that the gut microbiome - the community of bacteria and other microbes living in the intestinal tract - may contribute to the development and persistence of MDD. The microbiome is altered in patients with depression, and commonly used antidepressant drugs affect the microbiome. For example, studies have suggested that a diet high in anti-inflammatory foods (such as the Mediterranean diet) may shorten episodes of depression.

Opioid-Based Therapies. Compelling evidence suggests that abnormal opioid signaling may play a role in the development of MDD. This may help to explain why many patients don't respond to current antidepressant medications. Opioid mechanisms might also account for rapid antidepressant responses to the anesthetic drug ketamine. Strategies targeting one or more of the four opioid receptor subtypes might open new approaches to treating MDD and other stress-related disorders.

Technology in Depression Treatment. Wearable devices, global positioning systems (GPS), and other technologies may provide valuable tools for understanding the wide variation in symptom and disease expression (phenotype) of MDD. For example, GPS devices or fitness trackers may provide useful information on symptoms of social isolation, physical inactivity, and sleep disruption. These and other approaches such as natural language processing and ecological momentary assessment could provide real-time assessment of depression's impact on the lives of individual patients.

While current evidence-based treatments, including antidepressant medications and psychotherapy, are helpful for many people, an "unacceptably high" proportion of patients with depression derive no benefit from these treatments. "There's an acute need for new understandings of depression and its impact on patients' lives," Dr. Pizzagalli comments. "We hope the insights provided by the special issue papers will help to spur the development of new and better treatment approaches that our patients urgently need."

Source:

Journal reference:

Pizzagalli, D. A. (2020) Special issue: Harnessing Biology and Technology to Develop New Depression Treatments. Harvard Review of Psychiatry. doi.org/10.1097/HRP.0000000000000244.

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Harnessing biology and technology to develop much-needed treatments for depression - News-Medical.net

Watch: Why most parenting advice may be wrong – The Indian Express

By: Parenting Desk | Published: January 12, 2020 12:07:10 pm

From relatives, peers to books, everyone has a load of advice for parents to raise the perfect child. In a Ted Talk, professor of psychology and neuroscience Yuko Munakata spoke about how the parenting advice you receive can also turn out to be faulty.

The problem is that parenting books send conflicting messages. The one consistent message is that if your child is not succeeding, you are doing something wrong. Science supports a totally different message, she said.

Children can be shaped by many forces that are often intertwined like successful parents, successful genes, successful peers and a culture of success that they grow up in, the professor argued.

Everyone cant possibly be right about how parenting works, given how wildly beliefs have varied, said Munakata. The same style of parenting can impact children of the same parent in different ways. Your parenting can be shaping your children, just not in ways that would lead them to become more alike, she said.

Parents have influence but they do not have control, the professor emphasised.

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Watch: Why most parenting advice may be wrong - The Indian Express

Parker University Announces Clint Gilchrist as New CFO January 11, 2020Will Support Initiative to Expand – PR Web

Im honored to be at Parker University during this exciting time in our history. Im grateful to be able to play a part in continuing Dr. Parkers legacy and enhancing the educational experience for our students under the visionary leadership of President Morgan and the Board.

DALLAS (PRWEB) January 11, 2020

Parker University, the health and wellness college that is the 4th-fastest growing school in the state announced the hiring of Clint Gilchrist as its new CFO. Gilchrist, a CPA, was previously controller for Southern Methodist University. He will begin January 7.

Im honored to be at Parker University during this exciting time in our history. Im grateful to be able to play a part in continuing Dr. Parkers legacy and enhancing the educational experience for our students under the visionary leadership of President Morgan and the Board. he said.

The timing of the appointment couldnt be at a more crucial juncture. Parker University enrollment is at an all-time high. This past November, half its campus was destroyed in a freak tornado that blew through the area. This unfortunate event is now being used as a catalyst to raise funds to build a new outpatient chiropractic clinic, modernize research facilities, and enhance the student experience.

Its more important than ever that we have someone like Clint help us navigate these expansion years, said Parker President William E. Morgan. His experience in strategic financial operations for higher universities will serve us well.

The year 2020 marks both the 100th birthday of Dr. Parker and the 125th anniversary of the discovery of chiropractic. The school hopes to celebrate by showcasing a modern, rebuilt facility.With CFO Gilchrist at the helm, it seems highly likely they will be successful.

About Parker University

Parker University was founded in 1982 by Dr. James William Parker, originally as Parker College of Chiropractic; in 2011, it changed the name as its curriculum expanded. Today it is the 4th fastest growing college in Texas, according to the Dallas Business Journal. Parker University has 1,500 students and 27 academic programs including its famed chiropractic program along with masters degrees in neuroscience, clinical neuroscience, and functional nutrition. Currently, Parker Universitys chiropractic cohort is the second largest of any campus in the world.

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Parker University Announces Clint Gilchrist as New CFO January 11, 2020Will Support Initiative to Expand - PR Web

The anatomy of resistance: how the anti-CAA movement took shape in West Bengal – The Hindu

Abdul, 37, works at a roadside barbers shop in Agarpara. He does not know too much about what the NRC is or what it means for him. I know more now from having walked in rallies, though, he says.

When I ask him if he will participate in future protests against the NRC, he says nonchalantly, If need be.

Our area is mini India; we have people from every State here. We dont know any differences, he says.

Afterwards, he asks me if I am a journalist. You can draw a cartoon of a great ghost, he suggests, Label it NRC.

On December 19, Kolkata saw a 60,000-strong rally which managed to bring together people cutting across social, economic, cultural and religious groups.

Deliberations on resistance began in Kolkata in August 2019, a year after about 40 lakh people were left stateless after the publication of the second draft NRC for Assam.

"At first, it was only a vague idea: that we must do something to counter this," said Sukhendu Sarkar, Associate Professor of Economics at Sivanath Shastri College and social activist for over four decades. The 'No NRC' Movement group was formed with an organising committee of seven. On September 5, 2019, the organisation created a public Facebook group and within one month and five days, the member strength rose to one lakh.

The committee adopted several resolutions. "One of them was to not engage political parties or their frontal organisations in their organisational capacity. It was an open call to the people to be a part of the movement, so that anyone could be included" says Mr. Sarkar. "Our movement works on one core principle: that whoever is now residing in India and whose ancestors used to live in pre-1947 undivided India, must be treated as citizens of India."

At first, district-preparatory units were constituted. "We campaigned in 10 districts. In Howrah, North 24 Parganas, Birbhum, Maldah and Nadia, we were able to form district-level units," said Mr. Sarkar. From September to December, the No NRC Movement held 84 street-corner meetings and three rallies, and printed10,000posters and 5,400 booklets. 1,50,000 was collected in donations. "We place our monthly accounts every month before our members," said Mr. Sarkar.

However, on the day of the rally, the organisers were faced with an unforeseen issue. "After the CAA came into being, people came down to the streets spontaneously throughout the State, and in some areas, incidents of violence erupted. Long-distance trains were stopped, thus leaving out people from two of our key districts Maldah and Murshidabad," said Mr. Sarkar. These were the two places from where 30,000 participants were expected. Yet, the proportion that the rally assumed belied expectations.

It brought together students, teachers, artists, social activists; from queer communities and hijab-clad women, to jute mill workers. "The funny thing was that we had not been given formal permission for the rally. However, on the 19th, the police started requesting us to hold the rally adjacent to the Kolkata Municipal Corporation office the same place which had earlier been refused by the administration," said Mr. Sarkar.

Biplab Bhattacharya of Association for Protection of Democratic Rights, who was also a key convener of the December 19 rally, said youth participation at the district-level meetings was unprecedented. "At places like Chanchol or Harishchandrapur, we had 10,000 and 12,000 footfall respectively, which exceeded our expectations by far. With the CAA, the government has firstly managed to insult the sensibilities of the youth, having asked them to prove their citizenship. Secondly, it has hurt the Bengali identity."

Mr. Sarkar agreed: In Bengal, about two crores have been branded ghuspaithiyas - which is 20% of the State population. Of the 19,06,657 left out of the NRC in Assam, 18 lakh were Bengalis coincidentally, that is also 20% of Assams Bengali population.

However, while the protests have proceeded more or less unhindered, the situation is far from ideal, said Mrinmoy Sarkar, a member of Progressive Democratic Students Federation, who has campaigned for various protests in the State.

He has been a part of student protests in various institutions across Bengal, including Jadavpur University, Medical College, Indian Statistical Institute, Biswa Bharati, Presidency. On December 21, a rally of about 5000 students was conducted.

While Chief Minister Mamata Banerjee's declared anti-CAA stance has helped, it is not a situation that brings much hope, says Mr. Sarkar. When the amendment to the Citizenship Act was brought in 2003, there had been complete political silence. That was the root of today's troubles," said Mr. Sarkar.

Debotri Goswami, member of Feminists in Resistance, was recently in news after she and her colleagues were attacked while trying to hold a peaceful information campaign in Kolkata's Baghajatin. A man beat them up with bamboo sticks while chanting 'Jai Shri Ram'. Ms. Goswami believes their attacker had been "brainwashed". "When we tried asking him questions after he was subdued, he kept chanting 'Jai Shri Ram'. When people who had gathered around pounced on him, we tried to stop them. We offered him water but he refused it, saying he was sure we had poisoned it."

Even at the face of violence, Ms. Goswami believes peace is still the answer, ideologically and tactically. "People could see we had been singing and distributing leaflets when we were attacked. Solidarity poured in for us the next day," she said.

The No NRC Movement now aims higher. Their plan of action is to organise resistance through all the 23 districts of West Bengal.

Sukhendu Sarkar calls it a civic resistance expedition. On January 6, 2020, the group called for a meeting to devise a plan of action. Invitation to participate has been thrown open to the masses.

It has now added the cause of the JNU students who were violently attacked by masked miscreants to its agitation.

Ms. Goswami and Feminists in Resistance organised a flash mob, comprising 100 women, on January 4, 2020. The idea was for it to be like what happened in Chile, she said.

Their members have attended rallies organised throughout the State. In Kolkata, they have targeted the colonies of mostly settlers in the southern region, where they have distributed leaflets and conducted information campaigns.

We really believe in the power of music to spread messages, she said. Of course, we wouldnt go for Brahma sangeet. We know the masses wouldnt take to that. Instead, the group plans to use music like that out of renowned Bengali film Hirak Rajar Deshe.

Mrinmoy Sarkar also said that protests are now planned to go beyond first tier education institutes in the State. On January 8, the organisation participated in a State-wide students strike against police violence on students and privatisation of education. Campaigning is expected to reach out to districts like Hooghly and Murshidabad where student response has been massive.

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The anatomy of resistance: how the anti-CAA movement took shape in West Bengal - The Hindu

‘Grey’s Anatomy’: The Tragic Thing That Happened to Meredith That Everyone Forgets About – Showbiz Cheat Sheet

Its been a tough year for Meredith Grey. The mother of three and lead character onGreys Anatomy got fired from her job, spent time in jail, and faced the very real possibility of losing her medical license.

Thats not to mention her community service stint, her daughters health issues, and the end of her first stable relationship in several years.

But its more than the past year, Meredith Grey has definitely had to fight through some challenges to get to where she is today. And while many fans will agree that the death of her husband was arguably the worst thing to happen to the talented doctor, theres one tragic event that many fans seem to forget.

Meredith Grey has come a long way since she first met Derek Shepherd in Joes bar. That young faced intern has grown into an award-winning surgeon whos not afraid to take chances. But it hasnt been easy.

Meredith grew up without a father. Her father left when she was a child and eventually started a family with another woman. Her mother wasnt really there for her either, focusing more on her work than her young child.

Merediths issues were apparent from the very beginning of Greys Anatomy. She struggled with her relationship with Derek and battled very dark personal demons.

At one point Meredith fell into the Puget Sound and decided to give up fighting, dying before her fellow surgeons saved her.

Even though they were able to bring her back to life, she has spent her years learning to live alongside the demons of her past.

Meredith Grey and Derek Shepherd have always been the dream couple. Their relationship is one that you wish you had. Their love was instant and survived so many obstacles. When Derek died at the end of Season 11, fans were heartbroken. Meredith and the show would never be the same.

Meredith took her husbands death hard and she dealt with it the only way she knew how. She disappeared with her children in the middle of the night, and only returned when she gave birth to her third child.

Though Meredith has survived and arguably became a better doctor, her relationships and family have never been the same. It took a long time for her to open up herself to be with anyone else.

It can be hard to keep track of everything that Meredith Grey has had to endure. She has lost both parents, a spouse, siblings, and friends. She has been fired, suspended, and been personally challenged in ways that most people never will.

But theres one event that seems to be forgotten, not because it was unimportant or because it didnt affect the doctor, but merely because it is one of many tragic events.

During Season 12, Meredith was treating an accident victim. The victim had a seizure and suffered from post-seizure hyper-aggression. The typically mild-mannered man became suddenly and viciously aggressive. He attacked Meredith and left her helpless on the floor, as he faded back into unconsciousness.

It was several minutes until Meredith was found. At that point, she could not hear or speak. The attack also affected Meredith psychologically and she suffered from severe anxiety in the weeks that followed.

Its hard to say how much the events of that day and the weeks that followed truly effected Meredith Grey. And perhaps fans have become numb to the trauma the surgeon has endured because there has just been so much.

Throughout every tragedy, Dr. Grey has only come out stronger. While it may be tough to watch Meredith struggle so much, the pain and heartache have made her into the fearless doctor she is today.

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'Grey's Anatomy': The Tragic Thing That Happened to Meredith That Everyone Forgets About - Showbiz Cheat Sheet

Biochemistry Analysers Market: Strategic Analysis to Understand the Competitive Outlook of the Industry, 2030 – Citi Blog News

In 2018, the market size of Biochemistry Analysers Market is million US$ and it will reach million US$ in 2025, growing at a CAGR of from 2018; while in China, the market size is valued at xx million US$ and will increase to xx million US$ in 2025, with a CAGR of xx% during forecast period.

In this report, 2018 has been considered as the base year and 2018 to 2025 as the forecast period to estimate the market size for Biochemistry Analysers .

This report studies the global market size of Biochemistry Analysers , especially focuses on the key regions like United States, European Union, China, and other regions (Japan, Korea, India and Southeast Asia).

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This study presents the Biochemistry Analysers Market production, revenue, market share and growth rate for each key company, and also covers the breakdown data (production, consumption, revenue and market share) by regions, type and applications. Biochemistry Analysers history breakdown data from 2014 to 2018, and forecast to 2025.

For top companies in United States, European Union and China, this report investigates and analyzes the production, value, price, market share and growth rate for the top manufacturers, key data from 2014 to 2018.

In global Biochemistry Analysers market, the following companies are covered:

Thermo Fisher ScientificAbbottHORIBASiemens HealthcareXylem AnalyticsAgappe DiagnosticsRMSMicroLab InstrumentsLabindia Instruments

Segment by RegionsNorth AmericaEuropeChinaJapanSoutheast AsiaIndia

Segment by TypeFully Automated Biochemistry AnalyserSemi Automated Biochemistry Analyser

Segment by ApplicationHospital and Diagnostic LaboratoriesHome CareAcademic and Research Institutes

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The content of the study subjects, includes a total of 15 chapters:

Chapter 1, to describe Biochemistry Analysers product scope, market overview, market opportunities, market driving force and market risks.

Chapter 2, to profile the top manufacturers of Biochemistry Analysers , with price, sales, revenue and global market share of Biochemistry Analysers in 2017 and 2018.

Chapter 3, the Biochemistry Analysers competitive situation, sales, revenue and global market share of top manufacturers are analyzed emphatically by landscape contrast.

Chapter 4, the Biochemistry Analysers breakdown data are shown at the regional level, to show the sales, revenue and growth by regions, from 2014 to 2018.

Chapter 5, 6, 7, 8 and 9, to break the sales data at the country level, with sales, revenue and market share for key countries in the world, from 2014 to 2018.

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Chapter 10 and 11, to segment the sales by type and application, with sales market share and growth rate by type, application, from 2014 to 2018.

Chapter 12, Biochemistry Analysers market forecast, by regions, type and application, with sales and revenue, from 2018 to 2024.

Chapter 13, 14 and 15, to describe Biochemistry Analysers sales channel, distributors, customers, research findings and conclusion, appendix and data source.

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Biochemistry Analysers Market: Strategic Analysis to Understand the Competitive Outlook of the Industry, 2030 - Citi Blog News

Has the Average Human Body Temperature Always Been the Same? – Livescience.com

98.6. Why does that number ring a bell?

For years, the figure has held an important place in hospital rooms and physiology textbooks: 98.6 degrees Fahrenheit (37 degrees Celsius) is widely considered to be the "normal" average human body temperature.

But is this temperature still accurate? New research suggests the average American body temperature has dropped, and researchers think they know why.

Related: Why Does Being in the Heat Make Us Feel Tired?

A German physician named Carl Reinhold August Wunderlich was the first to crunch the 98.6 degrees number in 1851 after collecting millions of temperatures from about 2,500 patients in the city of Leipzig. "He took temperatures of everybody he could find, whether they were healthy sick, and he wrote a large book on temperature variation with illness," said study senior researcher Dr. Julie Parsonnet, a professor of medicine and of health research and policy at Stanford University. Wunderlich's work also highlighted temperature variations between people of different sexes, ages, weights and heights.

"Almost everything he said was correct," Parsonnet told Live Science. "He must have been sitting there with a pen, paper and pencil for an awful long time with all those temperatures."

Since Wunderlich's pioneering efforts, doctors still use body temperature as a key vital sign to help determine a person's health status. We now know that body temperature fluctuates as much as 0.5 F (0.2 C) throughout the day; that young people generally stay warmer than elderly people; and that women tend to maintain a higher temperature than men, depending on where they are in their menstrual cycles, according to a 2019 report in the journal Open Forum Infectious Diseases. Our body temperature also varies with the weather, our level of physical activity and whether we've eaten recently.

But why is it that, in general, the human body tends to hover around 98.6 degrees?

Evidence suggests that the body maintains a relatively stable temperature in order to keep its many organs and chemical reactions running smoothly, and potentially keep fungal infections at bay. But, according to the new study, published Jan. 7 in the journal eLife, the ideal body temperature may no longer be 98.6 F.

Rather, the average body temperature among Americans has dropped about 0.05 F (0.02 C) every decade since the early 1800s, the researchers found. American men born in the 2000s measure an average 1.06 F (0.58 C) cooler than men born in the early 1800s. Women born in the 2000s measure about 0.58 F (0.32 C) cooler than women born in the 1890s. The big question is, why?

As an infectious disease researcher, Parsonnet has spent many years studying a bacterial disease caused by the microorganism Helicobacter. The bug causes open sores called ulcers in the esophagus, stomach and small intestine and raises affected people's risk of developing gastric cancers. Over the years, though, Helicobacter infections have become less common in the U.S.

"I became aware, because I worked on it for 30 years, that that organism is disappearing from populations in the United States," Parsonnet said. The change reflects a larger trend; compared with our 19-century relatives, modern humans catch far fewer infectious diseases. People who lived through the 1800s were plagued with recurrent malaria, chronic wounds, tuberculosis, never-ending dental disease and bouts of dysentery, Parsonnet said.

Related: Why Is Humidity So Uncomfortable?

Today, we don't have all these bugs swimming through our bodies and revving our immune systems into overdrive. Parsonnet wondered how the loss of these microorganisms has altered human physiology through time.

To find out, Parsonnet and her co-authors dug through the data, including data sets from the American Civil War, the 1970s and the early 2000s. With these data sets combined, the researchers accrued more than 677,000 temperature measurements to examine.

The team spotted a steady drop in average human body temperature through the years. To rule out the possibility that improved thermometer technology had skewed the data, the researchers also looked for trends within each individual data set. Sure enough, the cooling trend appeared in each, regardless of the thermometer used by each historical group.

"We as human beings have evolved over time physiologically changed," Parsonnet said. "We've changed from who we were in the 19th century, and who we were in the 1960s, to a different human today that's colder."

The findings echo the results of a 2017 study conducted in England that analyzed about 250,000 temperature measurements from more than 35,000 patients. The average temperature among the British patients measured about 97.88 F (36.6 C), down a significant fraction from the "normal" average temperature of 98.6 F (37 C). Although humankind seems to be growing cooler by the decade, what does this actually mean for our physiology?

It's still a mystery, Parsonnet said. "We don't really understand what this cooling means in humans, what it means to our health, what it means to our longevity," she said.

Perhaps our decreased body temperature likely reflects the historical decline in infectious disease rates a trend that reduced excess inflammation in the human body to a significant degree, the researchers wrote in the study. Inflammation produces proteins called cytokines that ramp up the body's metabolic rate, thus generating heat.

Related: Why Do I Sweat So Much?

Additionally, unlike our ancestors, many people now live in a largely temperature-controlled world. "We don't have to work very hard to maintain our body temperature; it's always 70 F (21.1 C) in our houses," Parsonnet said.

Of course, it may be that people living in regions beyond the U.K. and the U.S. maintain entirely different body temperatures. For example, a 2008 study determined that the average body temperature in Pakistan still hovers around 98.6 F. However, these slight temperature differences between populations likely don't alter how our bodies function, physiologically, Parsonnet said.

"It might affect how microbes function, [but] I don't think we know the answers to those questions at all," she said. On the level of individuals, only extreme temperature changes signal worrisome health issues, such as fever or hypothermia. On a grand scale, though, average body temperatures may continue to fall as medicine advances and life expectancy increases, Parsonnet added.

Body temperature is "a marker of inflammatory state. And if you can take the temperature of a population, you might be able to predict their life expectancy," she noted. Parsonnet added that, someday, both life expectancy and body temperature will likely level off and remain consistent into the future.

Originally published on Live Science.

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Has the Average Human Body Temperature Always Been the Same? - Livescience.com

Who is Ivan Pavlov and What Did He Do for the Field of Psychology? – The Good Men Project

Ivan Pavlov was a Russian physiologist who discovered classical conditioning. He did a large amount of research on dogs and how they reacted to stimuli. He noticed that when he rang a bell, and there was food available, the dog would salivate. This is known as classical conditioning. Classical conditioning is something that many psychology students study, and its revolutionized the field of psychology. In psychology programs all around and outside of the United States, students learn about Ivan Pavlovs famous experiments in class.

Pavlov won the 1904 Nobel prize in physiology. He coined classical conditioning and researched digestion and physiology. At the beginning of his career, he studied religion, and then he moved to Science. In 1870, he started studying natural sciences while attending St. Petersburg University. Pavlov was primarily interested in physiology and natural science. He was instrumental in founding the department of physiology at the Institute of Experimental Medicine. Pavlov went on to oversee that department for 45 years.

When Pavlov was researching dog digestion, he found that a dog would salivate right before they got food. There were many stimuli presented to the dog. Pavlov determined that before he rang a bell after affiliating its sound with the presentation of food over some time, theyd notably salivate when they heard the bell, which meant that they were conditioned to affiliate the sound with food over time. This became a primary example of classical conditioning. He was awarded for this work, and in 1901, he was appointed to the Russian Academy of Sciences, three years before he won the Nobel Prize in Physiology.

Pavlov was not a psychologist, and in fact, he disliked psychology, but his work had a supreme impact on the field. His work influenced behaviorism. One of the earliest published works by Pavlov was the work of the digestive glands, and that was centered around his physiology research with dogs. He didnt intend to influence the world of psychology, but with his work regarding classical conditioning, great strides were made in the field.

In Pavlovs famous experiment when the dogs found the association between hearing the bell sound and the food, he called the bell conditioned stimulus because the signal served as a stimulation for behavior and he called the salivation a conditioned response because the salivated was the dogs response to the sound of the bell. It was determined that not only do dogs respond to stimuli in this way, but humans do, too. Pavlovs discovery of conditioned stimulus conditioned response, and spontaneous recovery taught us a lot about how our brains affiliate things with one another and how we can train our minds using this knowledge about how conditioning works. One common example of how we can implement this in our daily lives is in reward-punishment systems used by both children and adults. For instance, if a parent provides a child with a toy or sticker when they behave well, the child will be conditioned to affiliate good behavior with receiving a reward.

Therapy is a great place to learn about the modern applications of classical conditioning. Individuals frequently go to therapy to work on behavior or thought processes, and while the field has developed substantially since Pavlovs time, he had a significant influence on what we know and use in counseling today. Whether you see an online therapist or someone in your local area, you can gain insight in therapy thatll help you learn more about yourself and others.

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Who is Ivan Pavlov and What Did He Do for the Field of Psychology? - The Good Men Project

Research Associate – School of Physiology, Pharmacology & Neuroscience job with UNIVERSITY OF BRISTOL | 192171 – Times Higher Education (THE)

We are seeking to recruit a highly motivated Research Associate to be a part of a team working on a BHF-funded programme grant which focuses on the role of a specific population of brain cells in control in cardiac function in health and disease. The Programme, led by UCL will use a wide range of methods in animal models and also in human patients. The key hypothesis of the grant is thatVagal activity optimises cardiac function to support the physiological requirements of exercise.

Specific Aims of the project are:

Bristol is responsible for supporting this programme with new molecular tools and will also feed in the gene profiling and cellular-molecular aspects of the study. We will be developing and validating novel viral tools and gene expression analysis protocols, validating new tools and performing additional experiments to feed into joint publications. Hence, experience in generation of viral vectors is essential. Experience with handling animals and preparation of cultures and cultured slices is also very important. Applicants should have a PhD (awarded or imminent) in Physiology, Pharmacology and Neuroscience. We expect to get novel and exciting data which will be suitable for publications in high impact journals. The post would suit PhD graduates who have worked closely on related topics so that the project can commence without delay, although additional training will be provided where needed.

For informal enquiries please contact Professor Sergey Kasparov on +44 (0)117 331 2275, email:Sergey.Kasparov@bristol.ac.ukor Dr Anja Teschemacher on +44 (0)117 331 1461, email:Anja.Teschemacher@bristol.ac.uk.

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Research Associate - School of Physiology, Pharmacology & Neuroscience job with UNIVERSITY OF BRISTOL | 192171 - Times Higher Education (THE)