Vaginal rejuvenation surgeries are far more dangerous than doctors think: Study – MEAWW

After Jessica Pin got a labiaplasty -- commonly referred to as vaginal rejuvenation or female genital cosmetic surgery -- she realized she could no longer feel sexual pleasure.

According to experts, lack of training standards among surgeons, and lack of knowledge of anatomy and female sexual function in general, are the primary reasons behind such botched surgeries. What is worse, says Jessica, a volunteer researcher at the Baylor University Medical Center, Dallas, is that women are often told there are no risks to sexual function from these surgeries.

Jessica along with her father Dr. Paul Pin conducted a research where they found that crucial nerves of the clitoris -- the female sex organ that corresponds to the penis in men and is responsible for sensation and orgasm -- are at a huge risk of injury from such surgeries as doctors do not know the female anatomy well.

Surgeons and laypeople alike tend to conceptualize the clitoral hood as just a flap of skin covering the glans. However, in reality, most of the clitoral hood, operated on by many obstetrician-gynecologists (OB/GYNs) and plastic surgeons, is actually the skin of the clitoris itself. While surgeons often believe the dorsal nerves of the clitoris (two main nerves responsible for its sensation) are out of harm's way, Pins study revealed that they are located a few millimeters below the surface of the clitoral hood.

The primary implication of the study, says Dr. Pin -- chief of the Division of Plastic Surgery at Baylor University Medical Center, Dallas -- is that the dorsal nerves to the clitoris are the same size as the nerves of the penis and potentially just as susceptible to devastating injury during female genital surgery. The findings have been published in the Aesthetic Surgery Journal.

A labiaplasty is a vulvar surgery done to reduce the size of the labia minora the flaps of skin either side of the vaginal opening. Often, clitoral hood reductions are performed along with labiaplasty. In Pins case, a clitoral hood reduction was performed without her consent, and the nerves of the clitoris were cut. Her labia minora were also completely removed. Experts have told her complete, accidental amputations of the labia minora happen all the time.

According to the American Society of Plastic Surgeons, labiaplasty is the most commonly performed vaginal rejuvenation procedure and it can relieve symptoms women experience from twisting and tugging of the labia. However, it is primarily performed for cosmetic reasons, under the guise of a simple, safe procedure with the potential to even improve sexual function.

Additionally, says Jessica, labiaplasties and clitoral hood reductions are also commonly performed by OB/GYNs. Though there are no numbers for how many are done, advertisements for labiaplasty can be found on many board-certified OB/GYN websites. In one survey, 77% of OB/GYNs said they would perform labiaplasty. But how many they do is not tracked, says Jessica. While the focus is usually on the plastic surgeons performing these procedures, anecdotally, most surgeons with bad results have been operated by OB/GYNs, she adds.

For the current study, the researchers dissected the dorsal nerve of the clitoris by studying the vulvas of 10 women who had died. The study found that the dorsal nerves, clitoral glans, and the clitoral body were larger than expected. The dorsal nerves were 2.0-3.2 mm inside the clitoris itself. The researchers were surprised as doctors assume that the dorsal nerves in the clitoris are very small and difficult to dissect.

When we started our study, many standard texts completely ignored or poorly represented the sensory nerves to the clitoris once they enter the clitoris. Many anatomy diagrams, including virtually all OB/GYN textbook diagrams, showed the nerves approaching the clitoris, then the drawings just stopped. Adequate surgical anatomy has furthermore been missing from literature on female genital cosmetic surgery techniques. This does not happen with other surgeries plastic surgeons perform. Some doctors assumed the nerves to be too small to define, which our study proves they are not, Dr. Pin tells MEA WorldWide (MEAWW).

When you compare the detail of the anatomy of the penis versus that of the clitoris, you have to conclude that anatomists just didnt see female genital anatomy as important enough to justify equal representation, he says.

Jessica says while the study was published to help surgeons perform these surgeries safely, what she wants is for people to realize how careless surgeons have been in the past and continue to be by not pushing for this anatomy to be covered more. As is, this never would have happened without a mutilated patient (me) insisting. And there is something seriously wrong with that, she says. The innervation of the clitoris was also published in a major OB/GYN journal and OB/GYN textbooks for the first time this year, in response to her insistence.

Errors during such surgeries go undiagnosed and unreported due to the same ignorance of anatomy that causes them to happen in the first place, says the research team.

In the wake of my surgery, I was told it couldnt have affected my sexual function. This is despite visible scars in my clitoral hood (equivalent to penile shaft skin) and completely amputated labia minora. I was told I just needed to relax, just needed to fall in love, etc., Jessica tells MEAWW.

The removal of labia minora, as seen in Jessicas case, is not an uncommon result and again happens due to a lack of training standards, say experts. The labia minora are also sensitive tissue involved in sexual response. The fact that I was so young made it much harder to understand what had happened to me and why I had lost sensation. Given the age group most likely to seek surgery is 18-24, and that it is very common for women to lack knowledge of their genital anatomy, I believe there may be a huge problem with defining harm when it occurs, says Jessica.

The researchers say the knowledge of clitoral anatomy is important beyond cosmetic surgeries, and there should be training standards like there are for all other major cosmetic surgeries. Female genital anatomy is important and should be incorporated into all general anatomy textbooks and surgical specialty training. Some doctors have communicated that anatomy is already too demanding, however, a reasonable medical student could assimilate this additional material in a matter of minutes. Surgeons should reasonably be expected to learn this anatomy before performing female genital surgery, Dr. Pin tells MEAWW.

According to Jessica, when she consulted with one of the biggest female cosmetic genital surgery experts in the country, he had no explanation for how she could have lost sensation. For me to know I suffered from a dorsal nerve injury, I had to do my own research, teach myself the anatomy, diagnose myself, and then find a doctor qualified to confirm it. How many patients diagnose themselves? she writes in a blog.

Experts say professional organizations also neglect to get involved in this field due to the taboo.

Female genital cosmetic surgery has been controversial. For that reason, regulatory bodies, especially in OB/GYN, have not wanted to be involved in ensuring high standards of care. For example, while the American College of OB/GYNs approves these surgeries for medical reasons, they refuse to cooperate in the establishment of training standards, writes Jessica in the blog.

While such botched surgeries are not uncommon, very few women come forward as they fear being blamed. We do not have any idea how rampant botched surgeries are. Anecdotally, they are very common. Surgeons Ive spoken to have said things like I see this all the time. Most surgeons dont know what they are doing, says Jessica.

According to her, in almost every account she has seen of botched labiaplasties, the women have blamed themselves. When surgeons doing these procedures are, for the most part, doing surgeries they have not been trained to do on anatomy they dont know, it is not the victims fault, Jessica tells MEAWW. Jessica believes that most patients who have been harmed are in the dark like she was for so many years. I believe they dont even have the words to explain what happened to them. They are told they are crazy or that it is their fault. Or was told it was her hormones. And this silences them, she says.

She emphasizes what people need to understand is that all this amounts to systemic negligence. As long as women keep blaming themselves instead of directing blame at those actually responsible, this will not change, says Jessica.

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Vaginal rejuvenation surgeries are far more dangerous than doctors think: Study - MEAWW

Justin Chambers, Greys Anatomy Original Cast Member, To Leave the Show – mxdwn.com

Kayan Tara January 20th, 2020 - 9:00 AM

Deadline broke the news of Justin Chambers unexpected exit from medical drama, Greys Anatomy. Chambers will not get a dramatized exit, with his last appearance for the foreseeable future being the shows 350th episode, which aired Nov. 14, 2019.

Theres no good time to say goodbye to a show and character thats defined so much of my life for the past 15 years, Chambers said.

The popular ABC drama, created by Shonda Rhimes, is midway through season 16. The fate of Chambers character, Dr. Alex Karev, is currently unknown. In the Nov. 14 episode, the character was seen leaving the hospital to care for his ailing mother.

Chambers continued in the same statement to Deadline, For some time now, however, I have hoped to diversify my acting roles and career choices. And, as I turn 50 and am blessed with my remarkable, supportive wife and five wonderful children, now is that time.

Chambers went on to thank ABC, creator Shonda Rimes, the fans of the show, as well as the three other original cast members, Ellen Pompeo, Chandra Wilson and James Pickens.

Actors still on the award-winning show have commented on Chambers exit, with actor Jake Borelli, who plays Dr. Levi Schmitt, stating, Alex Karev, the character, has been a massive part of the show for so long, so its going to be interesting being in the hospital without that force.

Jason George, who now stars on Greys Anatomy spinoff, Station 19, said, Hes not the first person to leave the show and he wont be the lastif he says its time, its time.

The shows star Ellen Pompeo (who plays Dr. Meredith Grey) responded to Vanity Fairs news article about Chambers exit being one of Greys Anatomys biggest losses yet, stating Truer words have never been spoken @VanityFair, with a broken heart emoji.

Truer words have never been spoken @VanityFairhttps://t.co/KgoCS9TeVU

Ellen Pompeo (@EllenPompeo) January 11, 2020

Greys Anatomy, the longest running medical drama on television, will return with its midseason premiere on Jan. 23 at 9 p.m. ET on ABC.

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Justin Chambers, Greys Anatomy Original Cast Member, To Leave the Show - mxdwn.com

Station 19 season 3 premiere: How Grey’s Anatomy crossover… – CarterMatt

TheStation 19season 3 premiere is going to be arriving on ABC tonight, and this is an episode that starts with very high stakes. Theres really no other way to describe an installment that kicks off with first responders andGreys Anatomycharacters all in jeopardy due to an incident that happened at Joes Bar.

In the sneak peek below courtesy of ABC, you do still get a reasonably good idea as to where things pick up, and also what some characters will be doing to try and secure the area. There are a lot of issues going down here and its so much worse than just a car potentially falling on people (though thats pretty bad, as well). There is structural damage that could cause the building to collapse and then, beyond just that, there is also a chance that we could end up seeing gasoline leak down. If that happens and a fire starts well, you know what happens at that point.

For some moreGreys Anatomyvideo coverage,check out more of what we have to say about the future of Alex below! Once you do that, be sure to subscribeto CarterMatt on YouTube and then also view our full series playlist.

This upcoming premiere will carry over right intoGreys Anatomyitself and we can go ahead and predict there being some sort of all-hands-on-deck effort to ensure that nothing crazy happens and that everyone involved in the incident is okay. There are some other storylines that need to be addressed on theStation 19side, whether it be relationship updates or just learning more about how Ben is feeling about Baileys miscarriage, and they will probably be scattered throughout the story, as well.

Remember that the premiere is airing Thursday at 8:00 p.m. Eastern, and youre going to want to stick around for theGreys Anatomypart in order to get the full story.

Related News Be sure to get some more news right now when it comes to Station 19

Be sure to share right now in the comments, and be sure to also stick around for some other news on the series. (Photo: ABC.)

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Station 19 season 3 premiere: How Grey's Anatomy crossover... - CarterMatt

Global Biochemistry Analyzer Market Growth to Thrive with Technology Advancement by 2025 Dagoretti News – Dagoretti News

The latest insightful research study on the Global Biochemistry Analyzer Market 2020 released byMarket Research Explorecomprises valuable comprehension of vital facets in the global Biochemistry Analyzer industry. The report carries our significant elements such as market scope, history, structure, performance, maturity, trends, and growth potential with expansive analysis. It also enlightens precise sales, revenue, demand, production, and growth rate forecasts up to 2025, which have been extracted from a thorough survey of historical and current market performance.

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Get Sample of Global Biochemistry Analyzer Market Report 2020:https://www.marketresearchexplore.com/report/global-biochemistry-analyzer-market-report-2019-competitive-landscape-trends-and-opportunities/306480#enquiry

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More importantly, the report offers a complete financial assessment of companies based on gross margin, Biochemistry Analyzer sales volume, financial ratios, pricing structure, production cost, product values, profitability, and revenue. It also illuminates their product specifications, raw material sourcing strategies, concentration rate of major raw material, key vendors, manufacturing base, production processes, effective technologies, production volume, distribution networks, global presence, organizational structure, and corporate alliance. The proposed analysis will help market players intuit the strengths, weaknesses, and market positions of their rivals.

Get Expansive Exploration of Global Biochemistry Analyzer Market 2020

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The Biochemistry Analyzer types, applications, technologies, regions, and end-users are significant divisions of the market that have been intensely elaborated in the report. Each segment analysis considers its attractiveness, profitability, growth prospects, and futuristic demand. The study offers precise comprehension to market players to determine lucrative market segments for their Biochemistry Analyzer business and using appropriate business resources to maximize their gains.

Current and forthcoming market opportunities and challenges are also elucidated in the global Biochemistry Analyzer market report to assist market players to perform accordingly. Similarly, the report discovers potential market risks, obstacles, and uncertainties that could prove harmful to market growth momentum during the forecast period. Finally, the report delivers irreplaceable research conclusions that help players to build their own business and market strategies and make informed business decisions.

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Global Biochemistry Analyzer Market Growth to Thrive with Technology Advancement by 2025 Dagoretti News - Dagoretti News

Top Diet and Nutrition Issues to be Highlighted during Jan. 29 Media-only Event – Newswise

MEDIA CONTACT

Available for logged-in reporters only

Newswise Nebraska food scientists are at the forefront in some of the hottest food and nutrition issues in the country the microbiome, which some predict to be one of the top nutrition issues in 2020; obesity, which continues to be a major health issue for the nation; food allergens, with the CDC reporting rising prevalence of food alelrgies in children; and food choice behavior.

On Jan. 29, a dozen researchers and scientists will be at the Food Innovation Center (1901 N. 21stSt., Lincoln, Nebraska) at Nebraska Innovation Campus to discuss their groundbreaking work with the media. The event begins at 11 a.m. with a brief overview of each research program. After a provided box lunch, media in attendance will have six 15-minute sessions to interview researchers. At 2 p.m., optional laboratory tours will be available for photos and b-roll. The event will be live-streamed for media who cannot attend in person.

Participating laboratories:

Nebraska Food for Health Center,Andy Benson, director, professor of food science and technology; Amanda Ramer-Tait, associate professor of food science and technology; and Robert Hutkins, Khem Shahani Professor of Food Science and Technology. The center is located in the Food Innovation Center, 1901 N. 21stSt., on the Nebraska Innovation Campus of the University of Nebraska-Lincoln.https://foodforhealth.unl.edu

Nebraska Center for Prevention of Obesity Diseases,Janos Zempleni, director, Cather Professor of Nutrition and Health Sciences; Jiujiu Yu, assistant professor of nutrition and health sciences; Xinghui Sun, assistant professor of biochemistry; Yongjun Wang, research assistant professor of nutrition and health sciences; Edward Harris, associate professor of biochemistry; Alice Ngu, graduate research assistant in nutrition and health sciences. The center is located at 316C Leverton Hall, 1700 N. 35thSt., on the University of Nebraska-Lincoln East Campus.https://cehs.unl.edu/npod

Food Allergy Research and Resource Program,Joseph Baumert, director, associate professor of food science and technology; Melanie Downs, assistant professor of food science and technology; Philip Johnson, assistant professor of food science and technology; and Richard E. Rick Goodman, research professor of food science and technology. The program is located in the Food Innovation Center, 1901 N. 21stSt. on the Nebraska Innovation Campus of the University of Nebraska-Lincoln.https://farrp.unl.edu

Food Choice Economics,Christopher Gustafson, associate professor of agricultural economics, 314A Filley Hall, 1625 Arbor Drive on the University of Nebraska-Lincoln East Campus.

The Food for Health Center, a $40.3 million collaboration among academics, food and drug manufacturers and philanthropists, was established in 2017 to use microbiome research to link agriculture and food production to wellness and disease prevention.

Launched in 2014, the Nebraska Center for the Prevention of Obesity Diseases has received nearly $23 million from the National Institutes of Health to determine the molecular mechanisms that lead to obesity and to identify consumer friendly remedies.

For nearly 25 years, the Food Allergy Research and Resource Program has worked in partnership with the food industry to detect and eliminate allergens in the food supply.

Behavioral economist Christopher Gustafson is identifying the hidden factors that cause people to add an extra dollop of mayo to their sandwich or select an apple, not a brownie for a post-workout snack.

Please contact Leslie Reed at 402-472-2059 orlreed5@unl.eduto reserve your space, including lunch, parking and optional lab tours.

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Top Diet and Nutrition Issues to be Highlighted during Jan. 29 Media-only Event - Newswise

EXPLORER scanner captures real-time videos of blood flow and heart function – News-Medical.net

Positron Emission Tomography, or PET scanning, a technique for tracing metabolic processes in the body, has been widely applied in clinical diagnosis and research spanning physiology, biochemistry, and pharmacology.

Now researchers at the University of California, Davis and Fudan University, Shanghai have shown how to use an advanced reconstruction method with an ultrasensitive total-body PET scanner to capture real-time videos of blood flow and heart function.

The work paves the way for looking at the function of multiple organs, such as the brain and heart, at the same time. The researchers published their findings Jan. 20 in the Proceedings of the National Academy of Sciences.

The project makes use of the EXPLORER PET/CT total body scanner, originally developed by a team led by Professor Simon Cherry, UC Davis Department of Biomedical Engineering and Ramsey Badawi, professor of radiology in the UC Davis School of Medicine.

A commercial version named uEXPLORER is manufactured by United Imaging Healthcare of Shanghai, and an FDA-approved model is now in clinical use at UC Davis.

The breakthrough in this work is to capture the ultrafast whole-body dynamic tracer imaging with EXPLORER at the same time. We can see global changes with improved image quality at a timescale of 100 milliseconds, which was never seen before using any medical imaging modalities."

Jinyi Qi, professor of biomedical engineering, UC Davis

Qi and project scientist Xuezhu Zhang developed methods to reduce noise and reconstruct images from the raw data from EXPLORER scans of volunteers. They were able to see changes on a scale of 100 milliseconds, or one-tenth of a second and use these to create high quality real-time movies of the scans.

In a scan shown in the paper, a volunteer was injected in the lower leg with a short-lived radioactive tracer (PET scans work by following radioactive tracers in the body). The resulting video shows the tracer moving up the body to the heart, flowing through the right ventricle to the lungs, back through the left ventricle and on to the rest of the body.

"It's a combination of the scanner and advanced data reconstruction methods that makes this possible. This has applications in real-time tracking of blood flow over the human circulatory system, motion-frozen heart beating and breathing monitoring for cardiovascular and cerebrovascular disease and analysis of respiratory system function," Zhang said.

The video shows the motion of the heart with exceptional clarity. Changes in the cardiac contraction are well captured with clear delineation of the end-systolic and end-diastolic phases. While other techniques are available to measure heart function, EXPLORER's full-body scans provide opportunities for new studies that look at the dynamic function of multiple organs, such as the brain and heart, at the same time.

The scan shown in the paper was conducted at United Health Imaging and supervised by Zhongshan Hospital, Shanghai. The researchers are continuing to collect images from volunteers at UC Davis.

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EXPLORER scanner captures real-time videos of blood flow and heart function - News-Medical.net

Postdoc Position, Department of Biology job with MASARYK UNIVERSITY | 193197 – Times Higher Education (THE)

POSTDOC POSITION in Characterization of factors involved in metabolism of stalled replication forks and their possible disease relevance

Department Department of BiologyFaculty of Medicine

Deadline 29 Feb 2020

Start date March/April 2020 or upon agreement but no later than by 30th November 2020

Masaryk University, Brno, Czech Republic invites excellent scientists to apply for POSTDOC POSITION in Characterization of factors involved in metabolism of stalled replication forks and their possible disease relevance

Description:

The integrity of DNA continually resists the presence of physical and chemical carcinogens in our environment. In addition to exogenous agents, DNA undergoes spontaneous decay, including replication errors, oxidative and other damages which arise from common metabolic processes. The repair of damaged DNA is vital for the maintenance of genome integrity, and as aresult, all organisms have evolved awide variety of DNA repair pathways that can restore DNA structure and its genetic information.

The main objective of our research is to decipher the intrinsic functions of homologous recombination (HR) which has adual role in the maintenance of genome stability. First, it promotes the faithful repair of DNA double-strand breaks (DSBs) belonging among of the most lethal forms of DNA damage. Moreover, HR is responsible for the creation of genetic variability during meiosis by directing the formation of reciprocal crossovers that result in random combinations of alleles and traits. Changes in the execution and regulation of recombination are linked to human infertility, miscarriage and genetic diseases, particularly cancer thus emphasizing the importance of better understanding the mechanism and regulation of this pathway.

To achieve our goals, we utilize awide range of different methods from biochemistry, molecular biology, genetics, structural biology, and biophysics that are well established in our lab. Since we believe that interdisciplinary approach is needed to fully understand the fundamental biological processes, we also collaborate with numerous specialists.

The successful candidate should:

Specific criteria can be filled, i.e.:

The application should include:

MU offers the opportunity to get:

Anticipated start date:The position is available from March/April 2020 or upon agreement but no later than by 30th November 2020.

The submission deadline is29th February 2020.

Please submit your application by e-mail tovrablikova@med.muni.cz

Areview of applications will commence immediately after the deadline. Short-listed candidates will be invited for interview within one month of the deadline.

Further information about:

prof. MUDr. Martin Repko, Ph.D.dkan

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Postdoc Position, Department of Biology job with MASARYK UNIVERSITY | 193197 - Times Higher Education (THE)

UHS approves affiliation of 29 institutes – The News International

UHS approves affiliation of 29 institutes

LAHORE: The syndicate of University of Health Sciences (UHS) has approved the affiliation of 29 institutes for start of 56 new postgraduate and undergraduate programmes.

The 58th meeting of UHS Syndicate was held here on Monday with Vice Chancellor Prof Javed Akram in the chair. The other members who were present included Prof Talat Naseer Pasha, Prof Khawaja Sadiq Hussain, Prof Humaira Akram, Prof Nadia Naseem, Prof Nasir Shah, Dr Asad Zaheer and representatives of Punjab Specialized Healthcare and Medical Education (SHC&ME) and Finance departments.

The syndicate approved affiliation, extension in affiliation and enhancement of seats in various institutions after considering inspection reports of the affiliation committee. It approved Doctor of Medicine (MD) in the disciplines of psychiatry, radiology, gastroenterology, nephrology, cardiology, medicine, and paediatrics to be offered in different public sector institutions of the province.

Similarly, recommendations of the affiliation committee were approved for start of Master of Surgery (MS) in cardiac surgery, ophthalmology, neurosurgery, urology, and paediatric surgery.

The body also approved BSc programmes in the disciplines of nursing, Doctor of Physical Therapy (DPT), medical laboratory technology, dental technology, dental hygiene, nutrition, cardiac perfusion, medical imaging technology, orthotics and prosthetics, optometry and Orthoptics, and audiology to be started in different public and private sector institutions of Punjab.

Moreover, approval was also granted for start of MPhil Biochemistry, MSc Nursing, Diploma in Anaesthesia, and Diploma in Child Health.

The syndicate also approved the recommendations of MD/MS/MDS Reforms Committee to conduct intermediate examination on completion of 18 months of training rather than 24 months.

The policy of negative marking was also abolished for both intermediate and abridged examination in all disciplines in Central Induction Policy (CIP) scheme of MD/MS/MDS programmes.

It was also decided that the candidates who would pass written component of an examination in MD/MS/MDS, but fail in clinical and oral component, would be allowed a maximum of three attempts to clear clinical and oral component of that examination, failing which they would have to take the entire examination, including written component, afresh.

The syndicate also endorsed the VCs proposal to invite online applications for grant of affiliation in future besides creation of a dedicated directorate of affiliation in the University to deal with matters related to affiliation.

The members also approved award of PhD degree to Dr Rabiea Munir in the subject of pharmacology.

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UHS approves affiliation of 29 institutes - The News International

Science Talk – Tell me more about telomeres: how ‘basic’ science can help us treat cancer – The Institute of Cancer Research

Image: Chromosomes and their telomeres (visualised in red). Credit: Thomas Ried, NCI Center for Cancer Research

You might not have heard of telomeres but theyre incredibly important they are the caps that protect the end of chromosomes. They work like the plastic tips that stop your shoelaces from fraying.

All cancers alter telomeres in order to survive, so by doing basic research to try to understand how telomere replication and processing works, Max and his team hope to identify possible new ways to target and treat cancer.

Having joined the Division of Cancer Biology in October 2019, Dr Max Douglasis now one of the newest Team Leaders at the ICR. I met him at our Chester Beatty Laboratories in Chelsea, where he told me more about his work.

Max studied for his PhD in biochemistry and cell biology at the University of Cambridge. He then joined Dr John Diffleys team in Londons Clare Hall Laboratories which later became part of the Francis Crick Institute where he focused on studying the early stages of DNA replication.

At the Crick, he helped establish in detail how a protein complex called the CMG replicative helicase that helps unwind DNA during replication, is assembled and activated.

Now at the ICR, Max leads his own research team studying DNA replication but in the context of telomeres and cancer.

My main project is to rebuild telomeres in the lab and then unpick how they work how they are replicated and how they are processed. This knowledge is generally useful, but we will focus on studying it in the context of cancer, explained Max.

Lets finish it:help us revolutionise cancer treatment. We aim to discover a new generation of cancer treatments so smart and targeted, that more patients will defeat their cancer and finish what they started.

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When a cell becomes cancerous, it divides more often and every time it divides, its telomeres become shorter and shorter. Once there is no telomere left, the DNA unravels, like a shoelace fraying, and the cell dies. This eventually happens in most healthy cells telomeres shorten over time until cell division is no longer possible, leading to cell death.

While this loss of telomere protection can cause cancer cells and healthy cells to die, it can also lead to a state of genome instability that helps cancer survive and spread.

We also know that cancer cells can escape death by making telomerase, an enzyme that prevents telomeres from getting short. Certain cells in our body, such as stem cells, are able to divide over and over again thanks to telomerase. Cancer cells take advantage of this enzyme and hijack it to maintain telomere length which enables them to continue to divide and spread.

In other words, telomeres seem to play a role in the death of cancer cells but theyre also crucial for their survival. However, the molecular steps that guide telomere replication and processing remain poorly understood.

By using genetics and replicating cellular processes in a test tube, through a technique known as reconstitution biochemistry, Max and his team hope to better understand how telomeres are processed, and how they are inherited from one generation of cells to the next.

If Max and his team can dissect how telomeres work and clarify their link to cancer, maybe well figure out new ways to treat it.

His research might seem quite distant from the clinic, but Max knows he belongs at the ICR, which has an exemplary track record in making discoveries that ultimately benefit people with cancer.

I really value the ICRs commitment to doing basic, laboratory science. Good basic science is necessary to understand cancer, and the ICR values that. Here, I can figure out how to use my findings to benefit people, and that, in turn, will also hugely benefit my work, Max said.

I feel very lucky to work at an institution with a mission, being able to do what I love while getting opportunities to make discoveries that could help people.

As a new Team Leader, Max is currently the only member of his team but a higher scientific officer will be joining this month, as well as a post-doctoral training fellow, who will be joining in March. They will also start recruiting for a PhD student. As he told me, he cant wait for the new team members to join him in January.

Im excited to supervise other people for the first time. I want to build a strong team and a good environment for them to thrive in.

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Science Talk - Tell me more about telomeres: how 'basic' science can help us treat cancer - The Institute of Cancer Research

Understanding Human Behavior – A Physiological Approach …

As fantastically (and fanatically) self-aware organisms, we humans tend to ascribe great importance to our intellectual processes: Were rational and reasoning creatures, we assert, capable of stepping back and assessing our own behavior through an analytical lens.

Like any other biological entity, however, were interacting with and responding to our environment in myriad ways well beyond the realm of our conscious perception. We usually take these subconscious, autonomic aspects of our being for granted, but naturally, theyre fundamental to both our appreciation of the world around us and, critically, our day-to-day survival.

We dont need to compel ourselves to shiver when the mercury drops; our hand recoils at the lick of the flame or the bite of the dog. Thankfully, we dont have to think our way through the mechanics of walking in order to pull it off start trying to, and youre liable to beeline for the pavement.

The conscious and the nonconscious, the voluntary and the involuntary: When it comes to Homo sapiens, these processes arent either-or propositions. Theyre thoroughly intertwined, influencing and echoing one another. In short, human beings (breaking news) are complicated systems, and the study of human behavior a complex task. Parsing out behavioral and emotional nuances requires zoomed-in looks at the tempos and intensities of all kinds of physical and psychological networks and a holistic, big-picture perspective of how those networks interface with one another.

Researchers interested in how humans respond to stimuli, therefore whether its an Internet ad or an interpersonal encounter can enhance their investigations by employing biosensors that document psychophysiological patterns.

Self-assessment/ self-reporting remains a powerful and useful tool for understanding the how and the why of human behavior but has some major limitations.

People arent always entirely honest when describing how something makes them feel not necessarily because theyre trying to be duplicitous or crafty, but because they may feel pressured by the formal self-critical exercise to give what they think is the right answer (or the least embarrassing one).

Furthermore, its often exceedingly difficult to explain in coherent sentences our response to a piece of information, or our mood at a given moment. We may not know exactly why we favor one product over another, or why were feeling generally joyful or generally depressed (there are many techniques for honing a surveys efficacy you can learn more in one of ourblog posts).

Meanwhile, physiological data such as the rate of our heartbeat, the degree of our perspiration, and the direction and rhythm of our eye movements can shed light on behavioral phenomena our conscious minds may deny, distort, or completelyfail to register.

The academic and commercial applications of the psychophysiological studies considering such data are virtually limitless, relevant tofields as diverse as neuroscience, psychotherapy, marketing, and design.

Whats remarkable about such studies are the incredibly fine-scale insights into the human emotion that can be gleaned from the minute subconscious or involuntary phenomena.

Consider galvanic skin response or GSR. This is a measure of electrodermal activity: the relative conductance of our skin from perspiration. Sweating is an utterly autonomic operation that, in addition to its role in thermoregulation, is a reaction to arousal, from general excitement to flat-out terror. By measuring sweat production via skin conductance, GSR can reveal evidence for a stimulated, agitated state of being thats beyond a persons deliberate control including arousal too subtle to manifest on the self-aware spectrum.

Electrocardiography (ECG) registers the electrical signature of a heartbeat, revealing intricacies of their rate and variability that, like GSR, can demonstrate physiological, emotional, or psychological arousal.

Then theres electroencephalography (EEG), which tracks brainwaves via scalp-affixed electrodes that measure the electrical pulses produced by mass neuron firings. An EEG readout indicates the moment-by-moment geography of brain activity which cortex is excited when, basically as well as the brains overall state at a given time.

Eye tracking, meanwhile, quantifies when and where a subjects gaze lingers, the rhythm of reading, and other optical minutiae, while facial expression analysis looks up-close at the configuration of the faces musculature for clues to a persons emotions.

The information outputted by a single kind of biosensor can be intriguing and useful, but only to a point. For instance, GSR and ECG readings can suggest the condition of arousal, but not its valence, or emotional character. In other words, sweaty palms or a ramped-up heartbeat doesnt reveal whether were dealing with a love-at-first-sight (i.e., a positive stimulus) sort of situation or a figure-looming-out-of-the-shadows (i.e., a negative stimulus) deal.

Integrate those electrodermal and cardiac data with EEG, facial expression analysis, eye tracking, and other analyses, and youve got a much more multifaceted picture. Thats what iMotions is all about.

As we noted earlier, psychophysiological investigations have wide-ranging utility whether its a company trying to gauge the appeal of a new product design to a prospective shopper, or its a therapist treating a patient with post-traumatic stress disorder.

As research into human behavior continues to expand in concert with improvements in the technology and methodology for implementing that research it goes without saying that its applications will as well.

Read more:
Understanding Human Behavior - A Physiological Approach ...