To find intelligent alien life, humans may need to start thinking like an extraterrestrial – Space.com

HONOLULU Our hunt for aliens has a potentially fatal flaw we're the ones searching for them.

That's a problem because we're a unique species, and alien-seeking scientists are an even stranger and more specialized bunch. As a result, their all-too human assumptions may get in the way of their alien-listening endeavors. To get around this, the Breakthrough Listen project, a $100-million initiative scouring the cosmos for signals of otherworldly beings as part of the Search for Extraterrestrial Intelligence (SETI), is asking anthropologists to help unmask some of these biases.

"It's kind of a joke at Breakthrough Listen," Claire Webb, an anthropology and history of science student at the Massachusetts Institute of Technology, said here on Jan. 8 at the 235th meeting of the American Astronomical Society (AAS) in Honolulu. "They tell me: 'We're studying aliens, and you're studying us.'"

Related: 9 Strange, Scientific Excuses for We Havent Found Aliens Yet

Since 2017, Webb has worked with Breakthrough Listen to examine how SETI researchers think about aliens, produce knowledge, and perhaps inadvertently place anthropocentric assumptions into their work.

She sometimes describes her efforts as "making the familiar strange."

For instance, your life might seem perfectly ordinary maybe involving being hunched over at a desk and shuttling electrons around between computers until examined through an anthropological lens, which points out that this is not exactly a universal state of affairs. At the conference, Webb presented a poster looking at how Breakthrough Listen scientists use artificial intelligence (AI) to sift through large data sets and try to uncover potential technosignatures, or indicators of technology or tool use by alien organisms.

"Researchers who use AI tend to disavow human handicraft in the machines they build," Webb told Live Science. "They attribute a lot of agency to those machines. I find that somewhat problematic and at the worst untrue."

Any AI is trained by human beings, who present it with the types of signals they think an intelligent alien might produce. In doing so, they predispose their algorithms to certain biases. It can be incredibly difficult to recognize such thinking and overcome its limitations, Webb said.

Most SETI research assumes some level of commensurability, or the idea that beings on different worlds will understand the universe in the same way and be able to communicate about it with one another, Webb said. Much of this research, for example, presumes a type of technological commensurability, in which aliens broadcast messages using the same radio telescopes we have built, and that we will be able to speak to them using a universal language of science and math.

Related: Greetings, Earthlings! 8 Ways Aliens Might Contact Us

But how universal is our language of science, and how inevitable is our technological evolution? Do alien scientists gather in large buildings and present their work to one another via slides and lectures and posters? And what bearing do such human rituals have on the types of scientific knowledge researchers produce?

It was almost like trying to take the perspective of a creature on another planet, who might wonder about humanity and our odd modern-day practices. "If E.T. was looking at us, what would they see?" Webb asked.

The assumptions and anxieties of alien-hunters can creep in in other ways. Because of the vast distances involved in sending a signal through space, many SETI researchers have imagined receiving a message from an older technological society. As astronomer and science popularizer Carl Sagan famously said in his 1980 book and television series "Cosmos," that might mean E.T. has lived through a "technological adolescence" and survived nuclear proliferation or an apocalyptic climate meltdown.

But those statements are based on the specific anxieties of our era, namely nuclear war and climate change, and we can't automatically assume that the history of another species will unfold in the same way, Webb said.

Veteran SETI scientist Jill Tarter has told Webb that, in some ways, we are looking for a better version of ourselves, speculating that a message from the heavens will include blueprints for a device that can provide cheap energy and help alleviate poverty.

The ideal of progress is embedded in such narratives, Webb said, first of scientific and technological progress, but also an implicit assumption of moral advancement. "It's the idea that, as your technology develops, so does your sense of ethics and morality," she said. "And I think that's something that can be contested."

Even our hunt for organisms like ourselves suggests "a yearning for connectivity, reflective to me of a kind of postmodern loneliness and isolation in the universe," she said.

Webb joked that SETI researchers don't always understand the point of her anthropological and philosophical examinations. But, she said, they are open to being challenged in their ideas and knowing that they are not always seeing the whole picture.

"One thing Jill [Tarter] has said many times is, 'We reserve the right to get smarter,'" she said. "We are doing what we think makes sense now, but we might one day be doing something totally different."

Ultimately, the point of this work is to get SETI researchers to start "noticing human behavior in ways that could push SETI to do novel kinds of searches," Webb said. "Inhabiting other mindscapes is potentially a very powerful tool in cultivating new ways to do science."

Perhaps beings on another planet might use gravitational waves, or neutrinos, or even some other unknown aspect of reality we have yet to come across to send messages into the heavens.

Originally published on Live Science.

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To find intelligent alien life, humans may need to start thinking like an extraterrestrial - Space.com

Gail Fisher’s ‘Dog Tracks’: Don’t be fooled by puppy behavior to skip early training – The Union Leader

SOMEONE ASKED me recently how long it takes to train a dog. Theres no simple answer. It depends on many factors such as the dogs age, temperament and personality, breed or mixed breed characteristics, prior training if any, the chosen training method, and so much more.

A puppy younger than 3 or 4 months has a relatively clean slate, so training progresses quickly. A lot can be accomplished in just a few months, but the job continues. As the dog goes through adolescence, the owner needs to keep practicing to get through that teenage period.

An adolescent or adult dog, even one that hasnt had any formal training, has prior learning gleaned from experiences. Consequently, the dog has responses and behaviors that might affect training. For example, if a dog hasnt been trained to come when called, he likely has learned to ignore Come! or doesnt know that it means Right now without stopping to smell the roses. It will take longer to overcome that prior learning. Or if a dog learned to respond to the command sit ... Sit ... SIT ... SIT! ... SIT DARN IT!! it will generally take time to teach him to respond to a calm, quiet, sit.

When starting a young puppys training, learning happens quickly. But then comes adolescence. Just as with human adolescents, teenage dogs test the boundaries, often become self-assertive, are easily distracted and frustrate owners in other ways they might not be prepared for.

Puppy owners often tell us they dont need to start training classes (yet) because their puppy seems to have been born trained. He never leaves their property, always follows them closely when they walk with it off-leash (in a safe place, of course) and always comes when called. I smile, say how fortunate they are and then say, Just wait for adolescence. Actually, Im not quite that passive about it. I explain that teenagers push the envelope, and in a month or two, these born trained behaviors will likely disappear unless they are solidified through training.

The differences between puppy and adolescent behaviors can be observed in the dogs relative, the wolf, which makes the purpose of the developmental stages clear.

Several periods of a dogs psychological development relate to a wild canines very survival. Lets take the homebound behavior that owners report, in which the puppy doesnt wander from the yard, and the following off-leash that many owners enjoy in a young puppy. These two Velcro-like behaviors radically change in adolescence. Where previously the puppy was glued to the property, the adolescent is eager to explore the world outside the property line and might roam.

This time frame corresponds to the wolfs development. When adult wolves go off to hunt, young pups stick close to the den, playing together and waiting for mom and dad to return. Starting around 4 or 5 months of age, the youngsters begin to explore away from the den. This willingness to leave the safe confines of home corresponds with the time a wolf pack moves from its summer quarters, where the new pups are born, to the packs winter home, following a caribou herd for example. Nature has created this inborn safety net for the pups: Stay close to safe harbor, and when the time comes, a switch is flipped, and the adolescent is bold enough (and big enough) to travel.

While this developmental period has great significance in wild canids, it is no less apparent in dogs, and is called the Flight Instinct period. Generally starting between 4 and 6 months of age, the now-adolescent dog takes off on his own for the first time or doesnt come when called. Having your puppy in training before this happens often avoids issues, so this transition to adolescence might pass without any significant undesirable learning.

Regardless of how long it takes to train a dog, just start. The younger the better, but its never too late. Lay a solid training foundation, then use it throughout your dogs life. Youll both love the results.

Gail Fisher, author of The Thinking Dog and a dog behavior consultant, runs All Dogs Gym & Inn in Manchester. To suggest a topic for this column, which appears every other Sunday, email gail@alldogsgym.com or write c/o All Dogs Gym, 505 Sheffield Road, Manchester, NH 03103. Past columns are on her website.

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Gail Fisher's 'Dog Tracks': Don't be fooled by puppy behavior to skip early training - The Union Leader

Clay Christensens Lasting Impact On How We Think About Innovation – Forbes

Clayton M. Christensen, Professor of Business Administration at the Harvard Business School

The Innovators Dilemma was published in 1997 by Harvard Business School professor Clayton M. Christensen. The Economist named it one of the six most important books about business ever written. George Gilder, author, and supply-side economics pioneer, called it a masterpiece...the most profound and useful business book ever written about innovation.

The book was a revolutionary work that helped explain how well-run companies can fail when innovation creates new competition. This may seem like a subject reserved for tech entrepreneurs or business school faculty, but ultimately innovation affects everyones life in some capacity. Clays theory of disruptive innovation has become a must-read for anybody interested in innovation and has shaped the thinking of business leaders around the world.

A firsthand encounter with the innovators dilemma

Cree Research (now Cree) was an early pioneer in the development of blue LEDs. This is the technology that would power the LED lighting revolution and the eventual obsolescence of the Edison light bulb. But in the 1990s, it could be intimidating for small companies like Cree working on these disruptive new products. Cree believed in the incredible potential of the technology, but the big lighting companies werent interested. What did they know that Cree didnt? These companies had been in the lighting business for over 100 years and controlled over 70% of the worlds market for light bulbs. They had orders of magnitude more resources, hundreds of years more experience in both business and technology development, and far more financial resources. Why couldnt they see the potential of this new technology?

The light bulb goes off

When The Innovators Dilemma came out in 1997, what was happening at the big lighting companies started to make sense. These companies were well aware of the new technology; they just couldnt change their thinking to take advantage of it. They had become too good at making light bulbs.

One of the core principles of Clays theory is: the things that make well-managed companies successful are the same things that eventually lead to their downfall.

While technology is often the means to enable disruptive innovation, the opportunity comes from understanding human behavior. These organizations are able to maximize achievement over a long period of time, but their success inherently becomes focused on shorter-term metrics. These metrics make it nearly impossible to take big risks, invest in longer-term ideas, and react to potentially disruptive new technology or business models. These businesses become a victim of their own success as they fall into the trap of you get what you measure.

While this book was a revelation for the team at Cree, it doesnt contain any examples of LEDs or lighting. The book talks about disruption in the steel industry, mechanical excavators, and disk drives, but what it really describes is behaviors; why these companies and the people running them act the way they do. And that is why it is still relevant today. Innovation is ultimately about people. The book doesnt teach you what to think about problems; it teaches you how to think about problems.

Thinking beyond business

In 2010, Clayton Christensen published an article titled How Will You Measure Your Life, which talks about the three questions he asks his business school students to think about on the last day of class. They are:

While these questions might seem unrelated to his previous work on innovation, they are some of the same concepts applied to a different contextour personal lives. Most people wait until too late in their careers to ask themselves these questions. Ultimately, in both business and life, its not just about doing things right, its about doing the right things and their impact on those around you.

Clayton M. Christen passed away on Friday, January 24, 2020. I never met him in person, only through his books, papers, and talks that are available on YouTube, but his work shaped much of my thinking about innovation. As Clay said, I had thought the destination was what was important, but it turned out it was the journey. His journey inspired me and continues to inspire the next generation of innovators and leaders.

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Clay Christensens Lasting Impact On How We Think About Innovation - Forbes

Close-up nature: non-human animals that seem to imitate our behavior, attribute human actions and thoughts to them may be imaginative, but we can undo…

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Videographer Judy Lehmberg from Sunday Morning.

Ive been thinking and reading a lot about non-human animal intelligence lately. One thought that continues to go through my head is the meaning of the word anthropomorphic. The more I think and read, the more I feel that there is a word that shouldnt exist.

Anthropomorphic, from Anthropos (human) and Morphe (form), means attributing human actions and thoughts to non-human animals. Fine. Except who developed from whom? No other animals have developed from us. We, Homo Sapiens, are just 200,000 years old and one of the new children on earth. We didnt develop directly from wolves, elk or elephants, but they were here first. It is therefore logical that our thoughts and feelings developed later than those of another animal.

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And since we share a lot of similar structures and DNA with other organisms that were here first, it is logical to assume that our brain has evolved in a similar way and has some of the same intelligence and emotions. We should be talking about gorillaopomorphic or chimpomorphic or even animalmorphic, not anthropomorphic. They dont imitate us; we emulate them because they did it first.

The more time I spend watching animals, the more people I see in them. We have all heard stories about elephants mourning their dead, including the absence of a family member. Crows and ravens can pull up long cords that are attached to a horizontal bar with a piece of meat at the other end. They pull the line up as far as possible, catch it with one foot and repeat until the bite is within reach. A chimpanzee was discovered in a Swedish zoo, who spent his early morning hours hiding stones behind trunks and haystacks he had created and later using them to attack zoo visitors. I guess he didnt want company! I saw a fox woman bury the remains of one of her babies after a badger killed and ate most of it. Ive seen bisons and moose mourn their babies for hours, sometimes all day, after a wolf or bear has got them. We once saw a bison mother who had given birth to a stillborn calf fending off wolves for hours until she was exhausted. She then suddenly left just to return with some of her friends as reinforcements. There are many, many other examples.

One of the reasons I was thinking about animal intelligence was a story I heard years ago about an orangutan in a zoo that kept coming out of its closed enclosure and letting the rest of the orangutans out with it. I believed this story because I knew that orangutans were smart, but I had no evidence that it was true until the animal keeper in charge told it on NPRs Radiolab.

Jerry Stones was the chief zookeeper at the Omaha Zoo in Nebraska in the 1960s. One day, some of his guards came to him and said all orangutans were loose and up in the trees near the elephants. They all ran to the orangs, lured them back to their enclosure, and then tried to figure out how they got out. Jerry was certain that one of the guards had forgotten to lock the closet door. Over the next few weeks, this happened several times with the same results. The guards swore they would make sure the door was locked carefully. Jerry threatened to fire someone. A few days after the last escape, one of the guards ran to Jerry and said, You have to come to see this. They sneaked over to the orangutan enclosure and watched Fu Manchu, the dominant man, fumble at the door lock. There was something in his hand, but they couldnt find out what it was. When they saw, they found that he had a piece of wire that he pushed into the slot between the door and the door stopper and skillfully guided around the door latch. Then he pulled on both ends of the wire and the latch pulled out of its hole. You were free!

Jerry and the other guards were amazed, but they still had what it takes to stop the orangutans and confiscate the wire. They later noticed that Fu Manchu hid the wire in the area between his lower lip and teeth.

He wasnt just using a tool; He used a tool that he had never been taught before and kept it for later use. I guess his only mistake was that he was too naive to watch out for people spying on him.

We know that an increasing number of animals, from Darwins finches to chimpanzees, are able to use tools. But here an animal hid a tool that he knew would lose if it was discovered, and planned to use it in the future.

Two of the Goodall chimpanzees: On the left, Glitter watches her sister Gaia dig for termites.

Many biologists who study animal behavior reject the idea of a non-human higher intelligence or emotion. I had a very respected college animal behavior professor who was a young, uneducated woman who had the audacity to go to Africa to study chimpanzees, and horror of terror! She also had the nerve to give them human names, like David Greybeard and Frodo, instead of Chimpanzee 1, Chimpanzee 2, Chimpanzee 3 etc. Of course, this young woman was Jane Goodall, who has contributed so much to our knowledge of chimpanzees and is valid today as the worlds leading chimpanzee expert.

I wonder what we would discover if we were smart enough to understand their language. And if we really are the smartest species, why are we destroying the earth through overpopulation, global warming, habitat destruction, etc.? Maybe we should learn from them.

Judy Lehmberg is a former university lecturer in biology who is now shooting nature videos.

See also:

To see the extended Sunday Morning nature videos, click here!

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Close-up nature: non-human animals that seem to imitate our behavior, attribute human actions and thoughts to them may be imaginative, but we can undo...

Solvang speaks up: Letters to the editor for the week of Jan. 24, 2020 – Santa Ynez Valley News

Bruce Porter for supervisor

I am enthusiastically endorsing Bruce Porter for 3rd District Supervisor.

Bruce has a wealth of important experience from his years as colonel in the Army Corps of Engineers. This includes road construction, bridge building, water conservation, oil spill clean-up (think Kuwaiti oil disaster) and all aspects of practical infrastructure that is so important to the future of our county.

His after Army years of active community service, particularly on the Santa Ynez High School board and other community volunteer work has demonstrated his desire to serve and enhanced his experience for supervisor. His present career as a financial investment manager further prepared him to deal with county financial issues.

In these days of partisan bickering and political ambition, it is refreshing to have a candidate such as Bruce who is a registered Independent, not interested in partisan politics. He is free from the symbolic issues that have infected our modern governments. He has no interest in future elective office or counterproductive political ambitions. Bruce is very much in tune with the environmental and social traditions of Santa Barbara County.

My four years as county supervisor gave me the experience to understand how important a competent, multi-dimensional, and experienced person is to address the issues of our County, now and for the future. Additionally, the freedom from interest groups and posturing ideology is critical to independent and sound decisions that our county desperately needs.

For all the above reasons I heartily recommend Bruce Porter to be our next 3rd District Supervisor. And I invite everyone to join me in supporting his campaign.

Please be sure to vote on March 3!

Former 3rd District Supervisor

'Slick marketing'

Bruce Porters reference to farm-to-table petroleum made me laugh. Unfortunately, Porter is deadly serious.

As a candidate for Board of Supervisors in 2016 a position he lost to current Supervisor Joan Hartmann - he received more than $60,000 from a Political Action Committee backed by oil and gas industries. This year, 70% of the funding he has received comes from two well-known pro-oil contributors.

Porter states county rules and regulations make it almost impossible to implement alternative energy solutions. In fact, Santa Barbara County has taken great strides away from our dependence on fossil fuels.

We recently joined the Monterey Bay Community Choice energy program, which gives us more control over energy sources and includes renewables, while working with existing providers such as PG&E and Southern California Edison.

The county approved the Strauss Wind Energy project, which will double renewable energy production and provide for the electricity needs of 30 percent of the countys households.

Porter states that drilling will lower our greenhouse gas emissions (GHGs), but he is flat out wrong. Just one of three drilling projects up for review in our county will result in GHGs of 760 thousand metric tons of CO2, according to the companys own environmental impact review.

Its not rules and regulations that are blocking progress to a just and effective energy transition. Its moneyed special interests who think they can buy our votes. Use your vote on March 3 to tell them otherwise: Vote for Supervisor Hartmann, and against Bruce Porter.

Backing Bruce Porter in 3rd District

I would like to bring attention to the upcoming election and to the candidacy of Bruce Porter.

As we approach the unusually early March 3 primary election, I want to express my support for Bruce Porter in his bid to become the next county supervisor for the 3rd District.

Ive known Bruce for several years through his involvement in a number of local non-profit organizations. In that time, Ive come to know him as a straight-shooting, thoughtful leader with the ability to find common ground among groups with different viewpoints.

We need more of that in our county politics: someone with an open mind who will listen to the other side and reach a decision based on common sense, not political allegiances.

Im confident Bruce has the knowledge, tact, and skills needed to serve both the North County and the South Coast on the Board of Supervisors. His voice is one we desperately need in county government.

SYVAOR President 2020, Rotary Club of Buellton President 2019-2020

Porter places others before self

I support Bruce Porter for Santa Barbara County supervisor.

Ive known Bruce for a number of years. He has an amazing passion for our community and its citizens, and has dedicated countless hours in volunteer time to work hard for the benefit of others.

As chairman of the Santa Barbara County Chapter of the American Red Cross, Bruce demonstrated qualities of leadership and common sense that we also need to have on our county Board of Supervisors. He showed compassion for victims, charity for those in need, strength of character in times of adversity, and asked tough questions at budget time.

Additionally, I deeply respect Bruce for his integrity and leadership in so many other positions, such as the school board, Rotary, Boy Scouts and Youth Coalition. Ive also had the pleasure to attend a local veteran organization with Bruce and see his desire to support local veterans in the community first hand.

Bruce truly places others before himself, and has gained tremendous respect and trust from the community. I have no doubt that Mr. Porter will make an outstanding county supervisor.

Please join me in voting on March 3 for Bruce Porter for county supervisor.

Where is Mr. Porter?

During Bruce Porters previous attempt to become a supervisor, I attended some of his public events. They were tightly controlled appearances where his credentials were recited but he took few questions. His campaign office does not return phone calls. And just last week, Porter was the only candidate who chose not even to appear at a lively forum for voters. Is that a sign of respect and commitment?

In contrast, since being elected as supervisor, Joan Hartmann has been eminently approachable on any matter that concerned me or my neighbors. She has held countless townhall-like gatherings throughout the 3rd District, making herself available to listen and respond to all questions.

The job of county supervisor is an important one. Further, the District 3 Supervisor has often cast the tie-breaking vote on matters that affect the quality of our lives and the balancing of our budget. Joan Hartmann has proven that she takes the role seriously and devotes her time, energy and considerable experience to it. She has a proven record of leadership in advancing public health, the safety of our roads and neighborhoods, disaster response and water-wise policies.

Total compensation for the position is over $100,000 a year. Isnt this enough to ensure that a supervisor is financially able to give full time and attention to it?

Still, after four years, Porter will not pledge to leave his private job as financial advisor to the wealthy to give more than part-time to the tax payers of the county he would have pay his salary.

Focus on the basic source of violence

Thanks for the invitation to share my thoughts in the excellent OUR VIEW Shooting Blanks at Violence editorial published Jan. 3.

I agree wholeheartedly that something must be done. Emotional uproar focuses on the tools, most often firearms, as being the cause. Guns, knives, SUVs, and other inanimate objects do not exhibit the pervasive hostility, rage, anger exhibited during these killings. The core of the problem must be attributed to human behavior of the perpetrators. Investigating the why of the who is a cultural and psychological dilemma.

Drawing from my 75 years of observations, I sense a cultural trend to dehumanize the value of life, to shy away from civility, and a failure to accept personal responsibility for bad actions and decisions. Violence and gore dramatizations in the media, entertainment industry and games constantly are more graphic, and in my opinion are desensitizing individuals. Soldiers exposed to the horrors of battle develop PTSD. Yet the entertainment industry fails to accept any responsibility for potential long-term damage to developing minds and personalities.

I see a cultural trend that fails to address, even ignores, the basic concept of good versus evil. Hollywood personalities have an increasing influence on our value of life. The AR-15 is demonized for its role in taking human lives. Yet actors applauded Michelle Williams during the Golden Globe Awards for bragging how her real-life decision to murder her fetus led to her selection for Best Performance by an Actress. I challenge the editors to provide an OUR VIEW opinion comparing death statistics due to mass killings with firearms versus voluntary abortions for personal convenience. When do children earn their rights to life, freedom and pursuit of happiness?

How do we as a civilized nation solve this crisis of violence? In my humble opinion we start by going back to a simpler time when childrens heroes were police officers and soldiers, Hopalong Cassidy and Gene Autry, and teachers who encouraged recitation of the pledge of allegiance to our flag and a prayer before the start of the school day. Focus on the basic source of violence bad people.

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Solvang speaks up: Letters to the editor for the week of Jan. 24, 2020 - Santa Ynez Valley News

Banks have returned to the pre-2008 world of automatic credit-limit increases for credit cards used by already indebted people – Boing Boing

"Proactive credit line increases" (PCLIs) are when your credit card company increases your credit limit without your asking for it; it was very common prior to the 2008 crisis, but the post-crisis rules largely put a stop to it. Now, banks have figured out regulatory loopholes that allow them to throw PCLIs at their most vulnerable customers, leading to record-high national levels of credit-card debt of $880b as of last September, higher than the pre-crisis high.

Credit cards are the most profitable loans that the finance industry originates, and 2019 was the best-ever year for the banks' profits from credit cards, with interest rates soaring to a 20-year peak. The US banks made $179b in credit card fees and interest in 2019, and 2020 is projected to be even better. Credit-card debt is the fastest-growing form of debt in the USA.

Much of this PCLI activity is subprime -- extending credit to people who are already overburdened by debt and who will likely miss payments, leading to high penalties, which are extremely profitable for banks.

The number of people aged 19-29 in the USA who are more than 90 days late on their card payments just reached a ten-year high.

But after the stock slipped in 2017, [Capital One] executives came under pressure to show they could meet growth targets. They eventually tweaked their models to offer increases to more customers, betting on a quirk in human behavior, according to the person with knowledge of the decision, who asked not to be named discussing the talks. The firmsanalyses showed people tended to keep their card utilization steady, even after line increases. In other words, someone who used 80% of their credit line before the boost, would typically use the same percentage afterward, generating more revenue.

Other researchers had come to similar conclusions. For consumers who carry balances on their cards, nearly 100% of an increase in credit limits eventually becomes an increase in debts, according to a working paper by Scott Fulford and Scott Schuh for the Federal Reserve Bank of Boston. About half of U.S. credit card accounts carry a balance each month, the CFPB said.

Banks Are Handing Out Beefed-Up Credit Lines No One Asked For [Michelle Davis/Bloomberg]

(via Naked Capitalism)

Bernie Sanders commissioned the Government Accountability Office to study the consequences of the high degree of indebtedness borne by Millennials; the GAO's report concludes that Millennials dreams are being "crushed" by debts -- primarily student loans -- which have limited their abilities to seek good employment, good housing, and to save for retirement.

Modern Monetary Theory (MMT) (previously) is an alternative to neoclassical economics that holds that sovereign states that issue their own currency can't default on debts denominated in that currency (if you are the sole source of Canadian dollars and all your debts are in Canadian dollars, you can always pay those debts), and that deficit []

Robert Skidelsky is an eccentric British economist: trained at Oxford, author of a definitive three-volume biography of Keynes, a Lord who sat with the Tories as their economics critic during the Blair regime, who now sits as an independent who is aligned with Labour's left wing. Back in September, Yale University Press published Skidelsky's latest []

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Banks have returned to the pre-2008 world of automatic credit-limit increases for credit cards used by already indebted people - Boing Boing

BoJack Horseman ready for the next Season?or is the show called off? Check here to know more – Union Journalism

Netflix banger Bojack Horseman has a piece of bad news and good news for their fans. The good news is that they will release the second part of the sixth season soon. The second half of the season, consisting of eight episodes, will be premiered on January 31, 2019.

BoJack Horseman is an American animated Comedy series that streams exclusively on Netflix. It is an adult comedy show which stars a humanoid horse lost in its booze. The creator of the show is Raphael Bob- Waksberg The show was first aired in August 2014. Since then, the show gained extreme popularity and attention as the audience found the presentation relatable. The show depicts issues that the adult these days are dealing with regularly. It showcases problems such as racism, depression, anxiety, trauma, mental health problem, which is a catchy subject to talk about when it comes to human behavior. The show projects Surreal Humour, which engages more audience to watch the show.

From 2014 to present, they did very well to keep its audience binding to the show and attract for of them. The show. According to Raphael Bob- Waksberg, the creator of the show,Will Arnet, the voice behind the character BoJack Horseman, Arnet himself sometimes creates punches and lines for the character on the show. According to Raphael,Arnet is a great dramatic actor and knows very well how to play in-between emotions. Without Arnet, the success of the would-be less as to what it is now. Said in an interview.

Five seasons of the show are out already, and the sixth season is in progress. The first half has been, but the second half is yet to come. Sixty-Nine in total episodes has been out already. After a hectic day, the audience finds it very relieving to watch. The show has also proved to be a stress buster for most fans.

According to the team, the sixth season was the final season for the show, and there will be no further seasons. Netflix decided to put the show to an end. Hence respecting the decision, the show has come to an end.

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BoJack Horseman ready for the next Season?or is the show called off? Check here to know more - Union Journalism

How Uber and other digital platforms could trick us using behavioral science unless we act fast – MENAFN.COM

(MENAFN - The Conversation) Uber' buine model i incredibly imple: It' a platform that facilitate exchange between people. And Uber' been incredibly ucceful at it, almot eliminating the tranaction cot of doing buine in everything from huttling people around town to delivering food.

Thi i one of the reaon Uber i now among the mot valuable companie in the world after it hare began trading on the New York Stock Exchange on May 10.

Yet it US$82.4 billion market capitalization may pale in comparion to the wealth of uer data it' accumulating . If you ue Uber or perhap even if you don't it know a treaure trove of data about you, including your location, gender, pending hitory, contact, phone battery level and even whether you're on the way home from a one-night tand . It may oon know whether you're drunk or not.

While that' cary enough, combine all that data with Uber' expertie at analyzing it through the len of behavioral cience and you have a dangerou potential to exploit uer for profit.

Uber' hardly alone. Our reearch how the bigget digital platform Airbnb, Facebook, eBay and other are collecting o much data on how we live, that they already have the capability to manipulate their uer on a grand cale. They can predict behavior and influence our deciion on where to click, hare and pend.

While mot platform aren't uing all thee capabilitie yet, manipulation through behavioral pychology technique can occur quietly and leave little trace. If we don't etablih rule of the road now, it'll be much harder to detect and top later.

A platform can be any pace that facilitate tranaction between buyer and eller. Traditional example include flea market and trading floor.

A digital platform erve the ame purpoe but give the owner the ability to 'mediate' it uer while they're uing it and often when they're not. By that we mean it can oberve and learn an incredible amount of information about uer behavior in order to perfect what behavioral cientit call ' choice architecture ,' inconpicuou deign element intended to influence human behavior through how deciion are preented.

For example, Uber ha experimented with it driver to determine the mot effective trategie for keeping them on the road a long a poible. Thee trategie include playing into cognitive biae uch a lo averion and overetimating low probability event, even if a driver i barely earning enough money to make it worth her while. Driver end up like gambler at a caino, urged to play jut a little longer depite the odd.

Uber didn't immediately repond to a requet for comment.

Airbnb alo experiment with it uer. It ha ued behavioral cience to get hot to lower their rate and accept booking without creening guet which create real rik for hot, particularly when they are haring their own apartment.

While thee example eem relatively benign, they demontrate how digital platform are able to quietly deign ytem to direct uer' action in potentially manipulative way.

And a platform grow, they only become better choice architect. With it IPO' huge influx of invetor money to fund more data and behavioral cience , Uber could move into dangerouly unethical territory eay to imagine given it pat practice .

For example, if the app recognize that you are drunk or in a neighborhood you rarely travel to and one that it data how i high in crime it could charge you a higher rate, knowing you're unlikely to refue.

And it' not all peculation.

In an effort to deceive law enforcement trying to invetigate the company, Uber actually found a way to identify government regulator trying to ue it app and then prevented them from getting ride.

That' one reaon lawmaker and regulator have been dicuing the difficult, interrelated role of behavioral cience and tech for year . And ome companie, Uber in particular, have been invetigated for a hot of bad buine practice, from dicrimination to miuing uer data .

But mot of the manipulation we've identified and worry about i not exprely illegal. And becaue regulator are often unable to keep pace with the ever-evolving ue of technology and choice architecture, that' likely to remain o.

Given the abence of well-defined and enforceable legal guardrail, platform companie' propenity to exploit behavioral cience at uer' expene will remain largely unchecked.

One olution, in our view, i etablihing an ethical code for platform companie to follow. And if they don't adopt it willingly, invetor, employee and uer could demand it.

Since the mid-20th century, written code of ethical conduct have been a taple of U.S. companie. The legal and medical profeion have relied on them for millennia . And reearch ugget they are effective at encouraging ethical behavior at companie.

We reviewed hundred of ethical code, including one targeted at tech and computing companie. Baed on our reearch, we urge digital platform to adopt five ethical guideline:

All choice architecture employed on a platform hould be fully tranparent. Platform hould dicloe when they are uing the tool of behavioral cience to influence uer behavior

Uer hould be able to make choice on the platform freely and eaily, and choice architect hould limit behavioral intervention to reminder or prompt that are the leat harmful to uer autonomy

Platform hould avoid 'nudging' uer in way that exploit unconciou and irrational deciion making baed on impule and emotion. New reearch how that tranparent choice architecture can work jut a well

Platform hould recognize the power they poe and take care not to exploit the market they've created, including by abuing information aymmetrie between themelve and uer or oppoing reaonable regulation

Platform hould avoid uing choice architecture that dicourage uer from acting in their own bet interet. A Nobel Prize-winning behavioral economit Richard Thaler put it , we hould only 'nudge for good.'

Big tech and behavioral cience are now integrated in way that are making companie wildly ucceful, from buzzing toothbruhe that make cleaning your teeth eem rewarding to uing text to nudge poorer mother to ue health care .

While the reult can ignificantly enhance our live, it alo make it eaier than ever for companie to manipulate uer to enhance their bottom line.

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How Uber and other digital platforms could trick us using behavioral science unless we act fast - MENAFN.COM

Tiny organs grown from snake glands produce real venom – Science Magazine

Researchers grew tiny venom glands from nine different snake species, including the cape coral cobra.

By Erin MalsburyJan. 23, 2020 , 11:00 AM

Venomous snakes kill or permanently injure more than a half-million people every year. Yet researchers still know surprisingly little about the biology behind venom, complicating efforts to develop treatments. A new advance could help: Researchers have successfully grown miniature organs from snake stem cells in the lab that function just like snake venom glands; they even produce real venom.

Its a breakthrough, says Jos Mara Gutirrez, a snake venom toxicologist at the University of Costa Rica, San Jos, who was not involved in the study. This work opens the possibilities for studying the cellular biology of venom-secreting cells at a very fine level, which has not been possible in the past. The advance could also help researchers study the venom of rare snakes that are difficult to keep in captivity, he says, paving the way for new treatments for a variety of venoms.

Researchers have been creating miniorgansor organoidsfrom adult human and mouse stem cells for years. These so-called pluripotent cells are able to divide and grow into new types of tissues throughout the body; scientists have coaxed them into tiny livers, guts, and even rudimentary brains. But scientists hadnt tried the technique with reptile cells before.

Nobody knew anything about stem cells in snakes, says Hans Clevers, a molecular biologist at the Hubrecht Institute and one of the worlds leading organoid scientists. We didnt know if it was possible at all. To find out, Clevers and colleagues removed stem cells from the venom glands of nine snake speciesincluding the cape coral cobra and the western diamondback rattlesnakeand placed them in a cocktail of hormones and proteins called growth factors.

To the teams surprise, the snake stem cells responded to the same growth factors that work on human and mouse cells. This suggests certain aspects of these stem cells originated hundreds of millions of years ago in a shared ancestor of mammals and reptiles.

Miniature, lab-grown snakevenom glands

By the end of 1 week submerged in the cocktail, the snake cells had grown into little clumps of tissue, a half-millimeter across and visible to the human eye. When the scientists removed the growth factors, the cells began to morph into the epithelial cells that produce venom in the glands of snakes.The miniorgans expressed similar genes as those in real venom glands, the team reports today inCell.

The snake organoids even produced venom; a chemical and genetic analysis of the secretions revealed that they match the venom made by the real snakes. The labmade venom is dangerous as well: It disrupted the function of mouse muscle cells and rat neurons in a similar way to real venom.

Scientists didnt know whether the many toxins found in snake venom are made by one general type of cell or specialized, toxin-specific cells. By sequencing RNA in individual cells and examining gene expression, Cleverss team determined that both real venom glands and organoids contain different cell types that specialize in producing certain toxins. Organoids grown using stem cells from separate regions of the venom gland also produce toxins in different proportions, indicating that location within the organ matters.

The proportions and types of toxins in venom differ amongand even withinspecies. That can be problematic for antivenom production, says study author Yorick Post, a molecular biologist at the Hubrecht Institute. Most antivenoms are developed using one type of venom, so they only work against one type of snakebite.

Now that Clevers and his colleagues created a way to study the complexity of venom and venom glands without handling live, dangerous snakes, they plan to compile a biobank of frozen organoids from venomous reptiles around the world that could help researchers find broader treatments. This would make it much easier to create antibodies, Clevers says. The biobank could also be a rich resource for identifying new drugs, he adds. (Scientists think snake venom may hold the keyfor treatments against pain, high blood pressure, and cancer, for instance.)

Another new study, published earlier this month inNature, could also help. Researchers have assembled anear-complete genome for the Indian cobrathat could aid drug development. The organoids created by Cleverss team will provide an unprecedented and incredibly important new avenue to complement genomic information for venomous snakes, says the senior author of the cobra study, molecular biologist Somasekar Seshagiri of the SciGenom Research Foundation. Theyve done an amazing job making this work.

*Correction, 23 January, 1:35 p.m.: An earlier version of this story misspelledSomasekar Seshagiri's name.

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Tiny organs grown from snake glands produce real venom - Science Magazine

Ervaxx and Cardiff University Enter Collaboration to Develop Novel T-cell and T-cell Receptor-based Immunotherapeutics Targeting Dark Antigens | DNA…

DetailsCategory: DNA RNA and CellsPublished on Saturday, 25 January 2020 09:59Hits: 391

Collaboration also focuses on exciting research published earlier this week in Nature Immunology identifying MR1 as a target for novel anti-cancer immunotherapies

LONDON, UK I January 24, 2020 I Ervaxx, a biotechnology company pioneering the use of Dark Antigens to developT-cell receptor (TCR)-based immunotherapies and off-the-shelf cancer vaccines, has entered a licensing and research collaboration with a leading T-cell immunology group at Cardiff University (Cardiff, UK).

The new collaboration will support a multi-year research program with Prof. Andrew Sewell's T-cell modulation group at Cardiff University focusing on the discovery and characterization of T-cells and TCRs reactive to cancer-specific antigens and ligands, including Ervaxx' proprietary Dark Antigens. Ervaxx will fund the program.

The collaboration will also advance exciting new research published earlier this week by the Cardiff University team in Nature Immunology1, where they identified a T cell clone that recognized and killed multiple different types of human cancer, while remaining inert to non-cancerous cells. The T cell clone targets MR1, an MHC class 1-related protein, via an unidentified cancer-specific ligand. These exciting findings, validated in a preclinical model, open the prospect of immunotherapies with broad utility across patients with diverse cancers. This approach into previously unexplored cell surface epitopes complements and extends Ervaxx's exploration of novel cancer-specific antigens.

Under the agreement, Ervaxx gains an exclusive license to relevant Cardiff University patents claiming T cells and TCRs reactive to cancer-specific antigens. The Company has the right to advance resulting candidate T-cell/TCR-based immunotherapeutics and cancer vaccines through development and commercialization. Cardiff University is eligible to receive milestone payments on any candidates that advance from the discovery collaboration into clinical development and royalty payments on sales of any products that reach the market.

Prof. Andrew Sewell, Head of the T-cell modulation group, Cardiff University, commented:

"Ervaxx's Dark Antigens, which are derived from the 98% of the genome that does not encode known proteins, constitute a promising and yet untapped source of targets for immunotherapies. This collaboration will use our world-class expertise in T-cell biology to identify T cells and TCRs reactive to those targets and pave the way for a new wave of treatments in cancer, and potentially other areas. This includes our most recent discovery, published in Nature Immunology, of a T-cell clone that targets MR1 to recognize and kill cancer cells, irrespective of cancer or human leukocyte antigen (HLA) type, offering opportunities for pan-cancer, pan-population cancer immunotherapies."

Kevin Pojasek, CEO of Ervaxx, said:

"We are excited to announce this collaboration with Prof. Sewell's world-class research group. We have great hope that through the combination of this expertise with our Dark Antigens and application of our EDAPT platform, we will be able to identify further targets to expand our portfolio of TCR-based therapies and cancer vaccines. We are also thrilled to contribute to the development of the group's exciting new MR1 research, which shows early but enormous potential for the treatment of cancers. This partnership, which follows those with the University of Oxford, University of Cambridge and Johns Hopkins University School of Medicine, reinforces our ambition to collaborate with leading academic institutions and be at the cutting edge of the T-cell immunology field to drive the development of novel off-the-shelf cancer therapies."

Prof. Andrew Sewell is a member of Ervaxx' Scientific Advisory Board.

About Ervaxx

Ervaxx is pioneering the use of Dark Antigens to deliver targeted immunotherapies for treating and preventing cancer. Ervaxx Dark Antigens derive from vast untapped expanses of genetic 'dark matter' beyond the normal coding regions of the genome, which are generally silenced in normal tissue but can become selectively activated in cancer.

Ervaxx' powerful, proprietary EDAPT platform has been developed to discover and validate Dark Antigens providing an in-depth assessment of candidate antigens on primary tumor cells along with their immunogenic potential. The EDAPT platform has identified proprietary antigens that map to multiple solid tumor types and generate robust, antigen-specific T-cell responses. Ervaxx is advancing a pipeline of T cell receptor (TCR)-based therapies, off-the-shelf cancer vaccines and other immunotherapies leveraging these insights into the role of Dark Antigens in cancer.

Ervaxx was co-founded by SV Health Investors and is based on pioneering research at the Francis Crick Institute (London, UK). The company has offices in London, UK and a laboratory in the Bioescalator Building at Oxford University, UK. Ervaxx also has a strategic partnership with a global pharmaceutical company.

For more information visit: http://www.ervaxx.com

Ervaxx, Dark Antigen and EDAPT are trademarks of Ervaxx Limited

About the T-cell Modulation Group, Cardiff University

Cardiff University T-cell modulation group, within the Division of Infection and Immunity, consists of 16 researchers with a diverse skill and knowledge base that covers all areas of T-cell biology including T-cell genetics, molecular biology, protein chemistry, crystallography, and cell biology. The overall goal of the T-cell modulation group is to understand the genetic, biochemical and cellular mechanisms that govern T-cell responses to human disease. Our research outputs are extremely wide ranging and include basic studies which are aimed at understanding how the T-cell immune response is regulated, through to translational studies which are aimed at developing tools, diagnostics and treatments for human diseases such as cancer, HIV, EBV, tuberculosis and many more.

1Crowther, M.D., Dolton, G., Legut, M. et al. Genome-wide CRISPRCas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nat Immunol (2020) doi:10.1038/s41590-019-0578-8

SOURCE: Ervaxx

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Ervaxx and Cardiff University Enter Collaboration to Develop Novel T-cell and T-cell Receptor-based Immunotherapeutics Targeting Dark Antigens | DNA...