My ‘Tiredness’ Turned Out to Be a Genetic Condition That Raises Cancer Risk – msnNOW

Courtesy Jen B.

In 2012, Bev Michel found a large lump in her breast. This discovery started a medical odyssey that led to a cancer diagnosis and ultimately unraveled the mystery of a variety of health issues that had plagued her for more than eight years.

Following up on the lump with a mammogram and biopsy, Michel got the startling news that she had cancer. The West Chester, Pennsylvania resident immediately jumped into a chemotherapy regimen, undergoing six sessions of chemo and two lumpectomiesonly to find later after genetic testing that her type of cancer, lobular breast cancer, doesn't respond to chemotherapy. She then requested and underwent a double mastectomy, hoping to ensure the cancer was gone for good. But the cancer recurred in 2016near the nodes. So she again had surgery, this time to remove lymph nodes that she later learned were benign.

Michel felt there had to be more to her troubles, and she went to her general practitioner for guidance. "I told her how I was always tired, and how much my joints ached," Michel recalls. "She ran a couple of blood tests, and when she received the results she didn't believe them. She said my iron levels were sky-high, so she retested them. They were even higher." Michel's doctor diagnosed her with hemochromatosis, a metabolic disorder that leads to abnormally high iron levels in the body.

The mineral deposits itself into organs like the heart, liver, and pancreas, and in the joints; it can raise the risk of cancer and other diseases. A normal human absorbs about 8 to 10 percent of the iron they get from their diet; people with hemochromatosis absorb four times as much. The condition is inherited, and people with northern European ancestry have an elevated risk, according to the Genetics Home Reference. Experts estimate that 16 million Americans have elevated iron levels. Michel's diagnosis helped shed light on her family's medical history. "My mom died of breast cancer, had macular degeneration, and heart issueswhich are all signs of the disorder. When I had genetic testing, my results showed that both of my parents had the gene mutation, so of course, I would, too." (Here, doctors reveal the rarest conditions they've ever diagnosed.)

About one in 227 of people of Northern European descent have the condition, and about 10% of white people in the U.S. are carriers, according to National Organization for Rare Disorders. That means they have one copy of the gene mutation that causes hemochromatosis. You need to inherit two copies of the gene, one from each parent, to have the condition, although not everyone with both genes develops it. It's most often diagnosed in men after age 40 and in women after 60, in the postmenopausal years. While it's one of the most common genetic diseases in the U.S., it's less common in African Americans, and people who are of Hispanic, Asian, or Native American descent.

Michel was told she would need to donate blood every few weeks for the rest of her life, as giving blood regularly helps reduce iron levels. The prospect of this sent her to the internet to research other possible treatments. "What I found was that high iron is correlated to cancer, and I'm convinced it's what caused cancer for both my mom and me," she says."I found a doctor at the University of Maryland, Abulkalam M. Shamsuddin, MB, BS, PhD, who had studied the use of something called IP6 for treatment of cancer and iron overload." IP6 stands for inositol hexaphosphate: It's basically a carbohydrate substance that behaves like a vitamin, and it binds with extra iron in the body, explains Michael. "Once I began taking it, I haven't had a blood draw in two years, and my cancer has not recurred. My doctors are amazed."

Through her journey, Michel has found a passion for educating others about this relatively common yet underdiagnosed disorder. "I think there needs to be more open-mindedness among the medical community regarding treatments for conditions like this. Instead of treating only symptoms, look for the cause," she says.

If you have suspicious symptoms and you're not finding answers, Michel advises you be direct: "Ask to be tested for hemochromatosis. It's not an expensive test. If you have cancer, look for a possible correlation to your iron levels. If you test positive, then consider genetic testing for your children's sake. If you have it, they might, too."

Don't miss the 50 everyday habits that reduce your risk of breast cancer.

Gallery: 50 everyday habits that can reduce your risk of breast cancer

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My 'Tiredness' Turned Out to Be a Genetic Condition That Raises Cancer Risk - msnNOW

Is the consumer genetics fad over? – MIT Technology Review

The CEO of 23andMe told CNBC her company will lay off 100 people as sales of its direct-to-consumer gene tests slump.

This has been slow and painful for us, CEO Anne Wojcicki told the website, which estimated the cuts would pare about 15% of the company's staff.

Boom times: Sales of DNA tests that tell people their ancestry and health facts started booming a few years ago, propelled by TV and Internet ads hawking the promise that people could gain unique insights from their genes.

During 2018, the total number of people who had ever bought the tests doubled, swelling the databases of 23andMe, Ancestry, and several smaller companies to over 26 million people altogether.

The bust: Now, all signs are that sales of the $99 consumer tests slowed dramatically in 2019.

Our own calculations suggest the largest companies sold only four to six million of them, meaning the databases would have grown by just 20% during the year. That would have been the slowest growth rate for the DNA test industry ever.

Uncertain causes: It's not clear why consumers stopped buying tests in droves. It could be that the market is tapped out, and there aren't many people left curious to learn what percent French or Nigerian they are, or whether they are at risk for going bald.

Others may have concerns about their DNA data staying private, since police have started accessing smaller ancestry databases to carry out genetic manhunts.

Ancestry, which maintains the largest database with more than 16 million people, did not answer questions about whether it had seen a sales slowdown. Last year, Ancestry introduced new health offerings in what some analysts saw as a bid spark a "re-testing" market, or coaxing consumers to pay for an additional test.

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Is the consumer genetics fad over? - MIT Technology Review

Local News Doctors weigh in on pros and cons of genetic testing kits Brooke Hafs 5 – WGBA-TV

APPLETON, Wis. (NBC26) -- Genetic testing kits have grown in popularity.

Doctors say there's a time where it is appropriate to use them and a time when the information might not be sufficient.

At 59-years-old, Robin Vandermoss was diagnosed with cancer.

"It has tracked through my father and his father," said Vandermoss. "I just kind of want to put the puzzle together."

Now more than 6 months later he's undergoing genetic testing at ThedaCare.

"Hopefully we end up with some results that can be useful for my children and their children going on," said Vandermoss.

He's taking a route that doctors say is best under his circumstances.

As direct-to-consumer genetic testing kits grow in demand, doctors are informing people there are times to use them and times to seek an alternate route.

"If anybody has a strong personal or family history of cancer, heart disease or other conditions running in their family, then they really need a more formal evaluation," said Bobby McGivern, a Genetic Counselor with ThedaCare Regional Cancer Center.

Here's how these tests work.

You send a saliva sample in the mail. Your sample is tested in a lab and you receive your results revealing a plethora of new information about yourself.

Some examples of traits you can learn from a direct-to-consumer kit are:

Doctors say if you choose to use a gene testing kit that you've ordered online it's best to read the fine print.

Make sure you understand the capabilities of the test and look closely at the privacy information so you know what the lab is doing with your DNA.

Overall doctors say direct-to-consumer genetic testing kits have inspired a valuable trend.

"Families are talking more about family history," said McGivern. "They're asking some of the older relatives what is in the family, or maybe they're initiating some conversations with primary care doctors that they wouldn't have otherwise."

Use the kits wisely and seek a genetics referral from your primary care doctor if you have risk factors or a family history.

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Reflections on the Culturally Responsive Campus Community (CRCC) Conference – News – Illinois State University News

The Culturally Responsive Campus Community Conference drew big crowds of Redbirds looking to learn more about activism and solidarity.

The fourth annual Culturally Responsive Campus Community (CRCC) Conference was held on November 18 and 19 at Illinois State University. The overall mission of the annual CRCC Conference is to enlighten, educate, and ignite conversation around creating a more equitable and just campus environment for all. This years conference theme was Building Solidarity Across Movements.

With over 700 students, staff, and community members registered to attend, participants chose from 60 presentations, workshops, and discussions during the conference. Topics over the two days included working with international students, cultivating social justice learning through art and creative writing, anti-Blackness, Trans advocacy, diverse learning environments, fighting racial inequity, and challenging the norms of sexual violence.

There is something unspeakably beautiful about spending two days learning and connecting with passionate, intelligent, and caring people whose life work is that of justice. Unsurprisingly, many of the National Center for Urban Education (NCUE) staff, affiliated faculty, students, and community partners had a hand in various aspects of the conference.

CRCC Program Chair and NCUE-affiliated faculty Dr. Shamaine Bertrand and others questioned: What if we begin to build a sustainable movement across campus? Dr. April Mustian, CRCC Chair and Director of Faculty Development and INFUSE Coordinator for NCUE, stated the conference was aimed to be clear and honest about what is still standing in the way of reaching solidarity.

CTEP Director Jennifer OMalley speaks during the Neuroscience presentation at the CRCC conference.

NCUE staff and community partners heard this call and led two workshops during the conference. The first session was titled Cultivating an Understanding of Neuroscience to Empower Urban School Communities. Jennifer OMalley, Director of the Chicago Teacher Education Pipeline (CTEP) at NCUE along with Chicago community partners: Brienne Ahearn of North River Commission, Carlos Millan of The Resurrection Project, Ana Mosqueda of Latinos Progresando, and Gynger Garcia of Breakthrough shared how an understanding of fundamental concepts in brain development can empower educators. They affirmed that when neuroscience concepts are partnered with community knowledge, educators can bring empathy to any learning space to be truly culturally responsive.

The second NCUE workshop, led by CTEP Induction & Mentoring Director Apryl Riley, Melanie Christion of Greater Auburn Gresham Development Corporation, and Jose Guerrero, former CTEP staff and current Chicago Public Schools teacher, centered on restorative practices. Titled Promoting Equity and Teaching Empathy Through Restorative Circle Practices, the presentation showed how restorative practices are transformative ways to communicate with others and are intended to support and keep people accountable. Specifically, this presentation asserted that restorative circle practices are profound tools to integrate into urban education environments, K-12 classrooms and beyond. Restorative practices, characterized by awareness and intentionality, allow teachers and students to communicate more effectively with each other, and ultimately achieve a more equitable classroom.

Junior Genesis Robinson speaks at the main stage of the CRCC Conference, November 19.

The CRCC conference serves to ensure ISU and the surrounding community continues to commit to an inclusive, equitable, and culturally responsive campus. Genesis Robinson, a junior education major and two-time NCUE STEP-UP program alum, echoed this sentiment during her remarks to the conference audience attending the student-led session The Roots of Anti-blackness.

The way some people experience an institution is not the same as how others experience an institution. I think events like this shed light on that fact and how we need to see things from different perspectives, Robinson said.

NCUE is proud to be associated with such great leaders across our communities. Together, we aim to create a more just and equitable world for all.

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Reflections on the Culturally Responsive Campus Community (CRCC) Conference - News - Illinois State University News

How Women and Men Differ in Bed: It’s Complicated. – menshealth.com

Dean MitchellGetty Images

An important starting point for understanding sexual desire is to appreciate that hormones play a key role in motivating our sexual appetites and behaviors. In fact the operation of our sexual systems depends on a cascade of hormones that affect us at two critical points during our life cycleinitially during the course of embryonic development (these are called organizing effects, which establish the architecture of the brain/body) and later on, when we hit puberty (these are the activating effects, which turn on the wired-in systems).

Most people dont know that the masculinization of the brain and body happen during embryonic development at two distinct and separate points, facilitated by two different hormones, which has huge potential in clarifying some issues involving sexual orientation, gender identification, and transgenderism (in which the sex of the brain does not apparently match that of the body). As far as the activating effects of the hormones, we know that the hormone testosterone is responsible for the sex drive in both male and female mammals and people.

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What is not usually discussed (but has been well established) is that testosterone has more impact on the male mammalian brain. While it might be considered politically incorrect to call attention to fundamental differences in how male and female brains are wired, modern neuroscience has provided tons of evidence to support that there are indeed significant differences. Although it is true that the brain of each sex has some feminine and some masculine networks or circuits, if all goes according to plan in the process of embryological development, male brains simply have more places for the testosterone (and another hormone related to testosterone, vasopressin) to workby connecting with structures called receptors activated by the hormones. The receptive fields or places for testosterone to have influence are plentiful in the male brain. This feature explains the general finding that males tend to report having sex on the mind more frequently than females.

On the other hand, if all goes well during embryonic development, the female brain comes equipped with sufficient receptors sensitive to the hormone oxytocinthe hormone that is associated with decreased anxiety, increased trust, and social bonding. Oxytocin affects male brains similarly but there are substantially fewer oxytocin circuits in the male brain. Interestingly enough, the female sex hormone estrogen turns up the activity of the oxytocin circuits in the brain, while testosterone in the male brain fires up the vasopressin circuits, fueling competition and sexual interest.

Another fascinating aspect of female sexuality is that womens interest in the erotic can wax and wane in response to cyclical changes in brain chemistry. At peak fertility, when estrogen and progesterone levels are high, some women report more sexual thoughts and fantasies. Studies have also shown that women engage in more sexual behavior during their fertile periods (with rates of intercourse rising by 24 percent during the six days flanking ovulation). But way more than biology affects female sexuality. One need only read the fascinating research done by Dr. Meredith Chivers, a colleague from Queens University in Ontario, who has demonstrated that, in women, arousal of the genitals (as measured by blood flow in response to audiovisual erotic stimuli) simply doesnt translate into subjective sexual arousal or feeling turned on. In other words, blood flow to female genitals tends to be a nonspecific response to all sorts of erotic stimuli, regardless of the female participants sexual orientation, which doesnt necessarily correlate with feeling turned on. Blood flow to the womens genitals increases when the participants watched males with females, males with males, females with females, and even bonobos (those randy pygmy chimpanzees) getting it on.

This type of arousal is keenly different from how male arousal works: mens genitals only rise to the occasion, so to speak, in response to stimuli matching their own sexual orientation. And for men, increased blood flow to the penis in this type of study usually translates into increased subjective turn on. This explains why Viagra-type drugs dont work for women. With these drugs, you can indeed increase blood flow to the female genitals, but it doesnt do much for the ladies in terms of either subjective (experienced) arousal or desire. Suffice it to say that sexuality for women appears to have more complex underpinnings, which are not as well understood.

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Men and women also experience some aspects of sex differently. At first, in the early days, sexuality research by Masters and Johnson (1966), Kaplan (1979), and Lief (1977) described the sexual response cycle as a linear process that begins with desire/arousal, moves to a plateau or middle stage of intensified arousal or excitement, and then on to a third stage of orgasm and/or ejaculation. We have moved beyond this model not only because women dont fit neatly into it but also because we know so much more about the varying ways that humans in general become aroused and experience desire.

Several sexologists, including Beverly Whipple and K. B. Brash-McGeer and Rosemary Basson, distinguish the female sexual response cycle as being more circular than linear because there are so many more dimensions to what drives female desire and arousal. Basson shifted the nonlinear model farther by emphasizing that women are not necessarily motivated by sex for the release of orgasm but rather personal satisfaction, which may come through the emotional experience of intimacy with a partner. Essentially, for women, as compared with men, sexual desire might not be as driven by physically experienced horninessbut rather more motivated and accessed by and through the warm, intimate, and fuzzy partnership pathway.

Why are these models helpful or significant? Because they underscore that the pleasure of sex comes at different stages and in different forms: in the turn-on level of stimuli; in the predicted expectation that sex is going to happen; in the body-focused build-up of increased blood flow and muscle tension of the excitement and plateau stages; and ultimately in the release of the orgasm. If pleasure is experienced all along the way and is naturally variable, and the brains involvement is paramount, then how we think about solving our sexual problems needs to consider these realities.

Nan Wise, Ph.D., is AASECT certified sex therapist, neuroscientist, certified relationship expert. This piece is an excerpt from her new book, Why Good Sex Matters: Understanding the Neuroscience of Pleasure for a Smarter, Happier, and More Purpose-Filled Life, out Jan. 28, 2020. Follow her @AskDoctorNan.

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How Women and Men Differ in Bed: It's Complicated. - menshealth.com

Alum Embarks on Search For True Happiness, and Finds It All Across the USA – UConn Today

She should have been on top of the world.

Alumna Michelle Wax 12 (BUS), was in her mid-20s and already the owner of two successful companies in the food industry. Business was great, yet something was amiss.

I wasnt in a dark, dark place, but I found myself stressed out easily and with lots of self-doubt, Wax said. Thus began her search for greater happiness and fulfillment.

She isnt alone. A report released in March by the United Nations found that Americans are, overall, an unhappy lot. In fact, our international happiness ranking dropped for the third year in a row to No. 19 in the world. Americans have never been in the Top 10 since the report began in 2012.

Happiness is everyones ultimate goal, but how do we get there? Wax said. We think that well be happy when we reach that accomplishment or buy the house, or start the company, or meet the perfect person. Its always in the future.

But happiness today is easier to reach than you might think. Its a matter of taking control of your happiness and your life, regardless of outside people or circumstances. You dont need to accomplish a grand thing to feel fulfilled. It starts with small steps, if you know what they are.

Wax, a three-time entrepreneur, author, documentary maker and happy-life advocate, has created the American Happiness Project, consisting of workshops and programs designed to make participants feel more energetic and increase their personal sense of fulfillment. She presents at universities and corporations throughout the country. She has two presentations planned for UConn alumni, including one on Jan. 28 in Boston.

To develop her expertise, Wax spent months visiting all 50 states and creating a documentary from the conversations she had and the insights she got from truly happy people. Her subjects ranged from teenagers to people in their late 60s, from a variety of occupations and economic circumstances.

She spoke with people who were happy despite being diagnosed with late-stage cancer or whose homes had been destroyed in natural disasters. She also interviewed people with more routine struggles, such as disliking a job, feeling stuck in life, or experiencing stress and anxiety.

She has combined their wisdom with research on the neuroscience of how our brains are wired and how that ties into happiness. She studied how shifts in ones mindset can lead to greater tranquility.

The latest in neuroscience research ties directly into a persons happiness, she said. We can learn more about how our brains are wired and how we can use that to our advantage. There are easy steps you can start doing that impact your confidence, your belief in yourself, and your happiness, that can lead to a more fulfilling life.

During the course of her work, Wax found some common themes among people who are discontent.

Ive talked to a lot of people and what they seem to struggle with are questions such as Do I matter? and Am I making an impact on the world? she said. For many of these people, they are OK, theyre doing fine, but they dont have a strong sense of fulfillment and consistent happiness day to day.

Waxs program goes beyond work satisfaction to address life in a holistic way.

I have three goals in my workshops, she said. First, I want to connect people. Ive found that people are craving real connection. I want them to talk, get someones contact information, and follow up after the workshop to build a friendship. A lot of times we meet someone once at an event and have a great connection and never talk to them again.

Then we talk about neuroscience and how the mind is wired. If youre feeling stressed and are riddled with self-doubt, you can change that. My goal is to make that science more relatable and approachable and easy to understand, she said. Lastly, I give the audience immediate steps that they can take to improve their lives.

When I learned this knowledge and was able to change my mindset, it made such an impact on my entire life, she said. It had a trickle effect to the people in my life I truly care about, and hundreds of people since then.

Wax grew up in Dover, Mass., and her older brother Justin attended UConn. Michelle visited frequently and fell in love with the university.

She majored in management, with a concentration in entrepreneurship. One of her formative experiences was serving as vice president of event planning for the Student Entrepreneurship Organization. Meeting successful entrepreneurs, and hearing their encouraging messages, gave her the confidence to envision herself as her own boss.

During her junior year she interned at a tech startup, which eventually became LevelUp, a mobile ordering and payment platform that was acquired by Grubhub. She accepted a job there after graduation.

Within a year she was also running her own business, a cookie catering company called Kitchen Millie.

I started on the small side, doing it after work. I was able to build it up to a very successful business with prominent clients, she said. Kitchen Millie was named after my grandma. She was a good baker, but, more importantly, she instilled in me the importance of going after what you want and making it happen. So I did use some of her recipes, but it was more her character and attitude toward life that was the foundation of the business.

Having learned the ropes of entering the food industry, Wax started a second business, called The Local Fare, which helped coach and guide startups and growing food companies to leverage their success and avoid common mistakes. Last year she sold both businesses to devote all her time to American Happiness.

During her travels, from February to May of last year, Wax visited some of the countrys most beautiful locations. Through a LinkedIn posting, she was able to connect with people across the nation who were happy and content, despite having had some misfortunes in life.

I wanted to capture a broad range of people and discover how they had built happiness on a deep level, she said. One thing they all had in common was that they were excited about their lives, contributing to their communities, and living life with purpose.

New Englanders, she noted, tend to be more reserved in friendly conversation than people in other parts of the country. Shes a proponent of people taking a chance to reach out to others.

I got really good at talking to random people. Most people are open and honest and enjoy conversation once theyre approached, she said. I cant count how many amazing conversations I had just by saying, Hi. Hows it going?

Another lesson she learned is that people with a positive attitude are almost universally liked.

Positive people make a real impact. People like those who lift them higher, who are encouraging, who send a text that says, Youre amazing! she said. I found that those small gestures were so powerful.

Wax will share her American Happiness discoveries at a UConn alumni event in Boston on Jan. 28. A second presentation is tentatively planned for the Fall in Hartford. For more information, please visit alumni.business.uconn.edu or contact the Alumni Relations Office at (860) 486-2240.

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Alum Embarks on Search For True Happiness, and Finds It All Across the USA - UConn Today

New insights into globular glial tauopathy could aid in the design of better drugs – News-Medical.net

Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of phospho-tau, in other words tau associated to phosphate groups. Globular Glial Tauopathy, as well as Alzheimer's, are members of this large group. It is characterized by the accumulation of phospho-tau in neurons and by the formation of protein inclusions in glial cells astrocytes or oligodendrocytes. The majority of this kind of tauopathy is spontaneous, but some of them are caused by specific mutations.

This study published at Acta Neuropathologica journal, was led by Dr. Isidre Ferrer, from Bellvitge Biomedical Research Institute (IDIBELL), Medicine and Health Science Faculty from Barcelona University (UB) and Bellvitge Hospital (HUB), with the collaboration of Dr. Jos Antonio del Ro from Institute for Bioengineering of Catalonia (IBEC) and Biology Faculty from UB, both of them are members of Neuroscience Institute (UBNeuro) from UB. They studied several cases of patients with kind of tauopathy, genetic or spontaneous. The study shows that the addition of phosphate groups, is not specific to tau many other proteins are abnormally phosphorylated. This hyperphosphorylation induces protein disfunction and accumulation, which generates cell damage. Navarra Hospital also participates in these observations performing the proteomic and phosphorylation analysis.

Another relevant aspect of the study is that protein accumulation not only affects neurons, glial cells associated to them are also impaired, specifically astrocytes and oligodendrocytes. Glial cell affectation could promote the loss of some neural connections. Moreover, these inclusions can travel neuron to neuron or glial cell to glial cell, which facilitates the damage spreading to other cerebral regions.

These findings provide new information for the design of new drugs that stop disease progression. Firstly, new drugs must act in other proteins apart from tau since tau is not the only protein with increased phosphorylation. On the other hand, a new player has emerged in the scene, glial cells that not only are interfering in the cerebral damage, but they also participate in the spreading of protein inclusions. Finally, new drugs that stop cellular transmission of protein inclusions could be an interesting target for this disease.

Source:

Journal reference:

Ferrer, I., et al. (2020) Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy. Acta Neuropathologica. doi.org/10.1007/s00401-019-02122-9.

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Fr O’Neill’s bold witness on behalf of the unborn child will bear fruit – The Irish News

Niall Meehan (January 17) will recognise physics and metaphysics colliding when the ethics of abortion is discussed. Einstein said: Science without religion is lame, religion without science is blind.As a 1980s atheist teenager I favoured the pro-abortion position with a now discredited scientific theory, called Haeckels embryos, seeming to support early abortion. The study of human embryology as a medical student made me start to question the legitimacy of unrestricted abortion beyond a couple of months. The developing human form from two to three months into pregnancy cannot be denied.

Working in an obstetrics department involved scanning unborn humans; and gave me opportunity to see the developing foetus on ultrasound scan, with an obvious beating heartbeat separate from the mothers. The depth of emotional distress experienced by women suffering early pregnancy miscarriages informed me of a meaningful relationship between mother and child. A devout Catholic junior doctor housemate discussed in depth and detail the moral and scientific arguments against abortion. Donal sowed spiritual seeds which further sprouted when I went to work in the Scottish Gaeltacht as a GP.

Studying the science and ethics of abortion drew me to religious faith, and I decided to cease making NHS referrals for abortion. Many HSE GPs in the south wisely abstain from abortion involvement. NHS GPs in the north should do likewise. Amazing modern colour images on the CBRUK website instantly reveal a range of disturbing truths that pro-abortion politicians are too terrified to ever discuss. The clamour to fix exclusion zones outside abortion centres bears witnesses to the need for censorship. A CBRUK website section, The Facts-Human Development, equips ordinary people to oppose abortion using social media platforms. Knowledge is power, and we should share it.

Fr Eugene ONeill in Coalisland can have every confidence that his bold witness on behalf of the unborn child will bear fruit. St Paul tells us: Always work enthusiastically for the Lord, for you know that nothing you do for the Lord is ever useless. My friend Donal, who introduced me to the pro-life world view in depth, went on to have a very distinguished career in Irish medicine and completed Masters level degree study in medical ethics.Niall Meehan is wrong when he says: The words of men, however eminent, should be secondary to those who are pregnant.Knowledge of medicine and ethics, not a persons gender, determines their ability to give an expert opinion on the morality of abortion.

TJ HARDYBelfast BT5

Termination of children in the womb not justifiable under any circumstances

Responding to my letter Niall Meehan cites the X case and the tragedy of Savita Hallapanavar in a further attempt to justify abortion (December 27).

It is vital to this debate to bear in mind that we are dealing with real human lives, both born and unborn.

The X case concerns an act of abuse, perpetrated against an innocent child that resulted in her becoming pregnant. So you are dealing now with two children a 13-year-old girl and an unborn boy or girl.

There were two child victims in the X case both equally innocent.

In the case of Savita Hallapanavar, the law as it stood then in Ireland provided for an abortion in her particular circumstances to save her life. Inexplicably the hospital failed her.

Pro-abortion forces have shamelessly and cynically manipulated the sad case of Savita for their purposes of the liberal abortion regime in Ireland they were demanding and have now obtained, through the repeal of the 8th amendment.

The unborn child is now entirely at the mercy of so-called choice.Let me assure Niall Meehan not just I personally but very many people in Ireland, north and south that we will never accept the deliberate termination of children in the womb as justifiable under any circumstances.

We will work ceaselessly to oppose abortion and to persuade society that intentional abortion is never a solution, never an action that should be advocated by a humane and just society.

FR PATRICK McCAFFERTYBelfast BT12

Romantic meandering

Patrick Murphy Dissident Sinn Fin, IRA of 1970 lost great Irish opportunity (January 11) focuses on the events of the 1970s. The split a peace loving republican movement and a civil rights movement that would transform the six counties and indeed Ireland.

Where Mr Murphys article falls very short (has he a selective memory?) is the period before the 1970s.May I remind him of partition, Gerrymandering and bigotry that went before the 1970s. May I remind him of Malvern Street and Silent Valley? May I remind him of the civil rights marches that were met by such ferocity.All Mr Murphys article reflects is a finger-pointing piece targeting republicans that said no to a two-state nation led by the likes of MacGiolla. They saw the sectarian state in the raw, not through some rose-tinted glasses. There was not going to be a great Irish opportunity. What we had was a festering mess that Bernadette Devlin would say it was not a question of if but when it needed confronted.Mr Murphys romantic meandering are just that.

MANUS McDAIDDerry City

In the spirit of compromise

I noticed in the details of the historical and wonderful new power sharing Assembly at Stormont the British union flag will be allotted three additional days on which it can be flown from public buildings. In the spirit of compromise and equality can anyone say how many new days will be allotted to the flying of the Tricolour from these same public buildings?

COLM LONGDunmurry, Co Antrim

Call time on this mess

How can one maintain a good working relationship with a partner without mutual respect?

The new agreement in a peace process which has outlived the Troubles here is built on sand. The two main parties remain hell-bent on mocking, insulting, humouring and ridiculing each other. Add the increasing foreign influences on our respective cultures to the mix and we have a society with no moral and political fabric. Call time on this mess.

DESMOND DEVLINArdboe, Co Tyrone

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Fr O'Neill's bold witness on behalf of the unborn child will bear fruit - The Irish News

Richard Flavell Is Named a Distinguished Fellow by the American Association of Immunologists – Yale News

Richard A. Flavell, PhD, Sterling Professor of Immunobiology and aHoward Hughes Medical Institute investigator, has been named a Distinguished Fellowby the American Association of Immunologists (AAI), which calls this designation one of the highest honors that AAI bestows.

Flavell also is a fellow of the Royal Society and a member of the National Academy of Sciences, EMBO, and the National Academy of Medicine.His laboratoryuses transgenic and gene-targeted mice to study innate and adaptive immunity, T cell tolerance, and activation in immunity and autoimmunity, apoptosis, and regulation of T cell differentiation.

I am honored to be recognized in this way by the AAI, the premier immunology society, he says.

According to AAI, the honor recognizes "active, long-term members (25 or more years) who have demonstrated one or more of the following: excellence in research accomplishment in the field of immunology; exceptional leadership to the immunology community in academia, foundations, nonprofits, industry, or government at a national or international level; notable distinction as an educator."

Flavell is one of 20 scientists who have been designated Distinguished Fellowsfor 2020.

Submitted by Robert Forman on January 24, 2020

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Deep Bench: Importance of flu shot for older adults and those with chronic conditions – WSAW

(WZAW) -- Flu season is far from over. In fact, most flu activity typically peaks between December and February, and activity can last as late as May.

While the CDC urges the public to get vaccinated by the end of October, experts agree that for those who havent gotten their flu shot by the holidays, it isnt too late to get a flu shot in the new year.

On Friday, Dr. Payel Gupta, an expert in immunology and respiratory health joined the Deep Bench, along with JoJo O'Neal, an asthma patient.

Dr. Gupta said for those who may have put it off, recent flu activity trends emphasize the need for late season flu vaccination, especially for groups who are at increased risk of flu and flu-related complications, like adults 50 years of age and older and people living with chronic medical conditions.

"It not only protects you, but protects those around you," Dr Gupta said. "We've already seen 6,660 deaths in the U.S. from the flu this year alone, so it's a big deal."

She added that bout 70 percent of adults 50 years of age and older have one or more chronic illnesses such as heart disease, asthma or other lung disease, diabetes and cancer. When combined with the flu, these chronic medical conditions can become worse and cause serious illness, hospitalizations and even death. Directly, flu can worsen symptoms of respiratory disorders such as asthma and chronic obstructive pulmonary disease and can lead to pneumonia. Multiple studies have found an increased risk of heart attack and stroke in the first few days following a flu infection.

Thats why the American Lung Association and Sanofi Pasteur launched the MyShot campaign, empowering people ages 50 and older to take ownership of their health and ask their doctor about flu shot options that might be right for them.

ONeal is a 55-year-old radio personality living with asthma. In 2017, she became sick with the flu, and it took her over 10 days to recover. During that time, she passed the virus on to her sister and niece. Now, she is making an annual flu shot a priority and wishes to educate others older adults to do the same.

"Prior to getting the flu, I had not taken the flu shot, and I don't want other people to go through what I went through," O'Neal said.

For more information, visit getmyshot.org

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Deep Bench: Importance of flu shot for older adults and those with chronic conditions - WSAW