Wisconsin football: Is there hope for a Badgers win over Ohio State? – Bucky’s 5th Quarter

Well, your B1G West champion No. 8 Wisconsin Badgers (10-2 overall, 7-2 B1G) take on the No. 1 Ohio State Buckeyes (12-0 overall, 9-0 B1G) tomorrow in the B1G championship game.

The Badgers are pretty serious underdogs here, as the Buckeyes are about 16.5 point favorites. If Wisconsin pulls off the upset, this could very well be the biggest victory in program history.

Lets take a look at some of the common aspects of big upsets and how the Badgers may or may not be up to the task.

Before we get into the details, lets talk about how people are feeling heading into this one. Before the first Ohio State game and earlier this week, I posted a twitter poll, which of course is known for scientific accuracy.

Anyways, the tool was consistent from six weeks ago to now, so it is interesting to compare the poll results. We asked the same question both times with the same options: How are #Badgers fans feeling about Saturdays football game against OSU? Optimism - Apathy - Dread - Other. And, here are the results.

A quick Chi-Squared test confirms (p-value = .001) that this data suggests fan sentiment has shifted in the last month and a half. However, this shift has been rather small. Folks seem to be slightly more apathetic, less optimistic and are not dreading this game quite as much, but the ordinal ranking of the responses remain the same.

You can run through the twitter replies yourself, but here are a few highlights from our followers written responses to the poll:

Wisconsin is in a really strange spot. It has definitely earned a spot in the top 10, but absolutely nobody outside of Wisconsin is giving the Badgers a chance. The gap between Wisconsin and Ohio State is not as big as the gap between Virginia and Clemson, but both games appear impossible on paper.

Alright, so if Wisconsin is going to pull this thing off, what is it going to need to do? Well, Im done with grad school now, so why not start off with a literature review because I have not been punished enough.

I dont know why I thought the anatomy of an upset was clever, but when I googled it, I found hundreds of articles.

Im unique, just like everyone else.

After wading through a ton of nonsense, I found four resources that did a nice job talking about what has to go right for an underdog to win.

College Football Nerds bring this up all the time on their channel (although they are not alone in these resources). They point out a common mistake coaches make: trying to keep the game close.

Warning: paragraph about chess incoming.

This is the exact same thing in chess. The clearer the game is, the stronger player knows how to play you. Weaker chess players often try to play conservatively to avoid big mistakes, but instead the stronger player makes small improvements over forty moves and ends up with an insurmountable advantage. The one time I beat a Grandmaster, it was because I played an aggressive opening and keep the game dynamic. My position was worse, but I gave the GM opportunities to make mistakes.

We are done talking about chess now.

This is the key here: you have to give the other team opportunities to make mistakes. If you curl up into a ball, you may keep the game artificially close, but you will never have a chance to actually score more points. If you play ultra-aggressive, youll tend to lose by more points, but one out of ten times the stars will align and you will find an edge.

College Football Nerds assessed the October 26 meeting between Wisconsin and Ohio State as an overly-passive strategy, saying that Wisconsin relied on Jonathan Taylor too much and died a death by a thousand cuts. They also noticed that Taylor ran the ball more than Coan threw it against Ohio State. Further, they contrasted that with the Minnesota game when Coan threw the ball more than Taylor ran it.

My colleague Tyler Hunt thinks that Wisconsin will indeed be more aggressive this time around:

In this game, I expect the Badgers to continue with the aggressive to give themselves a shot. Punts and field goals arent going to win this game, so when the opportunity calls, take your shots.

I want to believe this, I really do. However, I perceive that Paul Chryst gets most aggressive against teams like Michigan and Minnesota that are closer in ability to Wisconsin, and he becomes more passive against teams like Illinois, Northwestern and Ohio State. Basically, I perceive Chryst coaching more aggressively against teams within one standard deviation of the Badgers and less aggressive against teams further away from Wisconsin in ability for better or worse.

Further, Chryst might decide that Wisconsins best realistic outcome is a Rose Bowl. In this case, he might try to just shorten the game and keep it close. Hunt noted this as well:

Sure Wisconsin can try to keep it close to back into a Rose Bowl, or they can be aggressive and let the chips fall where they may. I fully expect the Badgers to do the latter, and I cannot wait to see it. Shock the world boys.

Im not as optimistic that Wisconsin will go all-out, but I sure hope Tyler is right. We will know early on what kind of game this is.

I am not the expert in this, or else I would be making hundreds of thousands a year as an offensive coordinator. However, I will try ton take a stab at this.

I think the key mismatch is finding ways to get Taylor the ball out in space, preferably with one-on-one coverage by a linebacker. Its clear that Wisconsin has struggled to get Taylor into these situations out of conventional run plays, so Chryst will need to use Taylor in some new packages.

Lets go off the wall here. How about Wisconsin running spread looks out of the 22 personnel with Taylor lined out wide and maybe Mason Stokke, Nakia Watson or Garret Groshek in the backfield? Or, how about 11 personnel that lines up five wide?

Feel free to comment how these are stupid ideas, but I think its this type of thinking that could produce a successful game if it is filtered through a smarter schematic mind than mine.

In Football Study Halls series on anatomy of an upset, Bill Connelly looked at two big upsets form 2007: Appalachian States victory over Michigan and UL-Monroes victory over Alabama. Additionally, Ian Boyd added a piece to the series on Houstons 2016 upset win over Oklahoma.

The key thing to learn about these posts is each game went quite differently. For some turnovers were key, for some it wasnt. For some total yardage was important, for some it wasnt. And so on, and so on.

However, each of these upsets featured consistent success by the underdog in obvious passing situations.

Thats it. Success on obvious passing situations is important.

Moving on.

Ohio State is going to out-gain Wisconsin. If Wisconsin gains 150 yards in a quarter, you want that 150 yards to be mostly spread between few significant plays instead of being sprinkled over five 30-yard drives that end in punts or field goals.

Further, turnovers can neutralize Ohio States offensive production. A fifty yard drive becomes a thought experiment when it ends in a fumble.

You probably knew this, but turnovers and explosive plays are important.

Again, Ohio State is going to out-gain Wisconsin. When Ohio State makes it into the red zone, Wisconsin has to force several field goals.

Ohio State averages 4.8 red zone scoring attempts each game. Ohio State is the second best team in the country in terms of red zone touchdown percentage at 86%. That means, on average Ohio State scores 30.91 red zone points per game.

This is an easy stat to turn aroundit only takes a handful of successful defensive plays to change Ohio States effective red zone touchdown percentage.

First, Wisconsin needs to not allow any scores without Ohio State coming through the red zone. Next, it needs to cut Ohio States red zone touchdown percentage from 86% to about 25%. While the percentage drop is significant, that is only three more red zone stops over the course of a game. That is difficult yet achievable.

Assume Ohio State makes it into the red zone five times against Wisconsin. If Ohio State follows its season average for red zone production, that would turn into 31 Buckeye points. However, if Wisconsin can make four red zone stops instead of only one, that drops Ohio State down to 19 red zone points.

Three extra red zone stops would decrease Ohio States scoring by 12 points, which is almost 75% of the spread.

Each of these findings are about increasing variance: upwards for Wisconsin (taking more chances, success on passing downs and turnovers) and downwards for Ohio State (field goals instead of turnovers and strange mismatches).

Its a million-to-one shot, but its a chance Wisconsin gets to take.

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Wisconsin football: Is there hope for a Badgers win over Ohio State? - Bucky's 5th Quarter

Anatomy of the perfect Manchester United skipper | Sport – The Times

PREMIER LEAGUE | TONY CASCARINO

ROY KEANE The drive HeadKeane got the fans off their seats with his tackles, could lift his side with a stare and, at his best, there was an immense simplicity to his play it was ABC football, yet of the absolutely highest standard.

CRISTIANO RONALDOThe Adonis TorsoNot a natural pick as captain because of his individuality, but think about the way he led Portugal from the touchline during the European final in 2016. That was phenomenal. And then there is the obvious stuff: the white teeth, the Im-an-Adonis-follow-me inspiration, the crucial goals. He has turned so many games in his career. Thats as crucial as a roaring team-talk.

BRYAN ROBSONThe all-rounder ThighsHe may not have lasted long in the VAR era because

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Commentary: Dangerous interregnum: The anatomy of Ethiopias mismanaged transition – addisstandard.com

Ezekiel Gebissa, for Addis Standard

Addis Abeba, December 05/2019 In his Selections from Prison Notebooks, Antonio Gramsci famously wrote in 1930: The crisis consists precisely in the fact that the old is dying and the new cannot be born; in this interregnum a great variety of morbid symptoms appear.1He was writing about the late 1920s, an era epitomized since by economic recession, the rise of fascism and an imminent world war. In his concept of interregnum, the old order had lost authority, and its successor had yet to re-engender a properly functioning society. During such an interregnum, society could experience myriad problems, even chaos, and, in some cases, political violence.

In December 2017, the Ethiopian Peoples Revolutionary Democratic Front (EPRDF), impelled by a persistent popular uprising in the Oromia region, embarked on a program it described as deep renewal. This ushered in a process exemplifying Gramscis interregnum. The EPRDF-designed political system, anchored by institutionalization of a dominant party in exchange for rapid economic growth, is dying. A new system remains unborn or even unimagined. Previously banned political forces remain inactive or unable to offer alternative models. Morbid symptoms have begun to appear.

What diagnosis do these symptoms suggest? Interregnums are dangerous particularly if accompanied by unwillingness to imagine new power structures. In Ethiopias case, leaders of the reformed EPRDF have proven unable to manage the difficult process of democratization. Political authority has fragmented; a general feeling of national drift has raised the specter of state collapse. That would be the greatest geopolitical catastrophe in the Horn of Africa.

There was indeed an unmistakable reformist shift, and relaxation of political tension; the specter of state collapse faded.

MorbidSymptoms

EPRDFs embrace of deep renewal promised a new political dispensation. In Ethiopia, power-holders would henceforth be accountable to citizens through regular free elections, protecting rather than violating human rights; state institutions would provide good governance rather than function as an arm of the dominant political party. There was indeed an unmistakable reformist shift, and relaxation of political tension; the specter of state collapse faded.

In March 2018, the ruling EPRDF designated a new prime minister, Abiy Ahmed; he was sworn in in April. He implemented reforms with speed and gusto, gaining a receptive audience among Ethiopians. He visited nearly all regions, and diaspora communities abroad, preaching love, forgiveness and national reconciliation. He won over Western leaders with fashionable reform measures (e.g. appointing women) and occasionally expressing endorsement of liberal economic tenets. There was a deep reservoir of public support for the expressed commitment to reform and effort to ensure a transition to democracy.

Twenty months later, those glimpses of liberalization and democratic transition have proven a mirage. Symptoms of dysfunction are multiplying. The ruling party of the last three decades has lost its cohesion. Centrifugal forces and jockeying for power have soured relations within the EPDRF coalition, as each member resorts to a separate identity. As a party, the EPRDF is suffering an identity crisis, unsure of the political ideology that once gave it the coherence to govern effectively.

Because the party is essentially moribund, governance has collapsed. The prime minister holds on to power by deploying the military and the politicized state machinery. The regional states are in disarray, each with distinct challenges. Tigray is isolated, Oromia largely ungoverned and experiencing violence, the Southern Nations, Nationalities and Peoples Region (SNNPR) is unsure of its future, and the Amhara Region is the scene (and source) of political violence.

Contrary to the official portrayal of robust growth, the economy is in trouble. Increasing unemployment, runaway inflation, a foreign currency crunch, mounting debt, and credit difficulties characterize the current economic landscape

Contrary to the official portrayal of robust growth, the economy is in trouble. Increasing unemployment, runaway inflation, a foreign currency crunch, mounting debt, and credit difficulties characterize the current economic landscape. The newly unveiled Homegrown Economic Reform, sporting the language of the discredited Washington Consensus, has not addressed existing economic challenges. Will it ever work? Its only purpose seems to be to repudiate the developmental-state model of the prime ministers predecessors.

The worst features of EPRDF rule, which precipitated mass uprisings in recent years, have now returned with a vengeance. Mass arrests, lengthy detention without charge and other infringement of citizens rights, including illegal searches, restrictions on assembly, expression and movement, are commonplace. Security forces use threats, online filtering and other forms of harassment to intimidate opponents. Political party leaders and their supporters are subjected to illegal detention, with allegations of physical beating, and torture. In its 2019 annual report, Freedom House ranked Ethiopia as not free, with an abysmal record on political and civil liberties. Ethiopia today looks less like an example of successful political transition than of how democratization fails.

Inherent Dangers

Transitionrequires skillful management. Liberalization, the opening up of anauthoritarian order, if not managed competently, can quickly foment insecurity,sacrificing the very legitimacy a new regime needs most. In Ethiopias case,fateful mistakes were made at the outset.Inherent dangers were ignored.

Rejection of a Roadmap

There were several reasons for thefailure of democratic transition. One was lack of a clear agenda for the post-authoritarianperiod. The history of successful democratization attests that broad agreement among elites on transitionalguidelines and on procedures for popular participation is essential. Without a program that bridges the receding and emergingpolitical orders, there is little chance of successful transition fromauthoritarian rule to democratic governance.

At thebeginning of the Ethiopian transition, the prime minister was implored toconvene the major political parties to design a roadmap for the complicatedprocess of change. His initial response?I will be thebridge that ensures a successful transition. When the calls increased,he dismissed them: theterm roadmap has no meaning in political economy. In the absence of guidelines, every political actor acted to maximizetheir political fortune. Supporters clashed, with fatalities and destruction ofproperty. Cases in point are the incidents of September 2017, following thereturn to the capital of the Patriotic Genbot 7 and the Oromo Liberation Front(OLF).

Despite these warning signs, the prime minister showed no inclination to offer a program of transition, though he always talked about peace, forgiveness and love as a way forward. These notions have now coalesced into meddemer (addition), offered as the ideology of reform and transition. Such as it was, it came too late. The transition had drifted rudderless, producing more conflicts. Neither personal bridge nor infantile philosophy could substitute for a roadmap for transition.

Return of the Old Guard

Another danger the EPDRF leadership ignoredhas been the old guards determination to return to power. Democratizationis naturally redistributive of political and economic power; it threatens elitepower and dominance. In 2014-18,when a revolutionary protest movement of the disenfranchised threatened EPDRFsmonopoly of power, the political elite joined the movement for change ratherthan continue to confront it. However, they remained focused on regaining theirgrip on power.

The new leadership assumed responsibilityfor leading the transition but did little to guard it against counter-revolution.With decision-making concentrated in the prime ministers office, the old elitein the capital easily returned to dominance, filling key positions with politicalloyalists and party apparatchiksadmittedly opposed to democratization. Thebusiness elite bought a place at the table, and donated millions to the primeministers favorite projects in exchange for kickbacks in government contracts.The business and political elites have indeed successfully mounted an internalcoup detat, hijacking the revolution and dislodging genuine agents of change.2

Strategic mistakes

Popular protests toppling authoritariansystems do not always succeed in establishing democratic systems. To succeed,the first order of business is assembling forces of change in support of transition.In Ethiopias case, either political miscalculation or failure to heed itsimportance was a strategic mistake, resulting in lack of support from theforces that brought about the transition.

In a speech at Bahir Dar University in April 2018, the prime minister retorted: Amhara nationalism is growing at an alarming speed. Please study it. Oromo nationalism has taken [Ethiopias] largest population and diminished it. Instead of thinking at a national or continental level, it has reduced the Oromo to village level politics. This failed to endear him to Amhara nationalists, whose objective was to ride the wave of rising Amhara nationalism to regain their long lost power. On the other hand, the supercilious description of Oromo nationalism enraged Oromo nationalists. In effect, the prime minister alienated the Amhara nationalists he sought to restrain and antagonized the Oromo nationalists who had catapulted him into office. The forces of counter-revolution were ushered in to take the reins of power, thus jeopardizing the transition at the outset.

A second strategic mistake was the failure to recognize that the goal of transition was a state fulfilling longstanding demands for liberty, equality, justice and human dignity. For half a century, political struggle had focused against a centralized political system that excluded, marginalized and oppressed the majority of Ethiopians. But instead of envisioning a reconstructed state, EPRDFs reformist leaders thought in terms of restoring Ethiopias glorious past as a state. In political terms, the prime ministers vision of return was tantamount to repudiation of the sacrifices of the last five decades. Worse, glorification of the horrid Ethiopian state became an impediment to moving forward to a democratic state.

A third strategic mistake was the failure to recognize that the mandate is to serve as either a caretaker or a transitional government. Crucial to the caretaker function was rebuilding the state apparatus damaged during the protests. Whatever the reasons, the government proved unable to reconstitute the lower rungs of administration and failed even to gain control over the territory it was meant to govern. Public security, the most important responsibility of any government, broke down. Violence proliferated. For the first time in more than two decades, the regime itself looked vulnerable to implosion.

There are indications that the next national election, ostensibly the end of the transition process, was beset with problems even before the campaign could begin in earnest

As a transitional government, the regime hadto prepare for democratic elections. There are indications that the next national election,ostensibly the end of the transition process, was beset with problems even beforethe campaign could begin in earnest. The new electoral law was issued onlyeight months before the elections scheduled for May 2020. Complaints from theopposition include difficulties with party registration, opposition to elementsof the new electoral law itself, and questions about the impartiality of theelectoral commission. Electoral officers are not being recruited and trained.Polling logistics are not being organized. There are, in fact, no visiblepreparations for elections. A constitutional crisis is in the making.

Atthe federal level, the prime ministers centralizing decision making hasundermined institutional autonomy of government agencies and subvertedestablished processes. Federalentities are tasked with acting in the public interest, and while the executivehas an administrative supervising function, it has accumulated unchecked ad hocpowers. This has eroded the functional autonomy of government institutions anddegraded transparency and accountability. The failure to rebuild lower-level state institutions, and the primeministers personal decision-making style have paralyzed the delivery of publicservices, rendering the government utterly dysfunctional.

CurrentChallenges

The model of democratic transition adopted inEthiopia was in any case flawed from the very beginning. The process of designingand implementing a transitional roadmap did not include all political actors. Iteschewed broad social and political consensus for a new political system beforeholding elections. Empowerment of old-regime elites in the transition process, exclusionof nationalist parties, neglect of the protest movements demands, andantagonistic political forces have now doomed the democratic transition.

For many months the Abiy administration has looked for a coherent agenda for rallying the country. Instead, it has resorted to public relations stunts, including an urban sanitation campaign, a beautification project in Addis Abeba, tree planting to set a world record, palace renovation, and employing psychologists to conduct a national catharsis to cleanse citizens minds of ethnocentrism. Culminating this dreary grab bag were the prime ministers book launch festivities. Together or alone, these do not constitute a sustainable national project.

Flouting recognized processes and norms and circumventing established state institutions, which the prime minister has made his standard mode of operation, rewarded incompetence and destabilized the government

An ad hoc approach to governing leads tomistakes and wastes time on damage control. Flouting recognized processes andnorms and circumventing established state institutions, which the prime ministerhas made his standard mode of operation, rewarded incompetence and destabilizedthe government. Left to proceed withouta program, the transition has now unraveled, further diminishing the countrys alreadyfragile governing institutions. The states demonstrable vulnerability has emboldenedanti-reform forces, spelling disaster for the prospect of a successfultransition.

EPRDFs constituent members and associated parties are dissolving themselves into a single multinational party organized around the meddemer ideology. The Oromo Democratic Party (ODP) and the Amhara Democratic Party (ADP) have rushed the merger through their party echelons even though there is no consensus for merger. Suffice it to mention the very public rejection of both the party merger and so-called new ideology by Lemma Megerssa, ODPs deputy chairman. The Tigray Peoples Liberation Front (TPLF) has rejected the merger for now, suggesting more pressing national issues to address. The merger frenzy has proceeded without the TPLF. This is tantamount to excluding the Tigray region, with grave consequences for the cohesion of the Ethiopian National Defense Forces. Clearly, the apparent merger is fraught with legal and constitutional problems, and is being rushed with no clear political purpose other than the party leaders singular interest in dismantling the EPRDF before the elections.

The country is thus in a dangerous interregnum. At a time when established political groups are in flux, new alliances and counter-alliances will make the political landscape more unstable. Given that the Ethiopian state is fast losing its monopoly on violence, with armed units roaming several states, what we have now is an emerging phantom state (a state without administration), teetering on the verge of collapse. If the state fails, others will step in to provide security for themselves. There is a clear danger that political maneuverings might descend into predatory states (administration without a state) in the regions. AS

_______________________________________//_________________________________

EDs Note: Ezekiel Gebissa is a Professor of History and African Studies at Kettering University in Flint, Michigan. He can be reached at egebissa@kettering.edu

Notes

1AntonioGramsci, Selections from the Prison Notebooks of Antonio Gramsci,ed. and trans. Quintin Hoare and Geoffrey Nowell-Smith (London: Lawrence &Wishart, 1971), 275-276.

2 For a detailed account of the players, methods, conflicts and hijacking of power and the process which sidelined nationalist party leaders and eventual triumph of the counter revolution, see, Mudhin Siraj, YeTetelfe Tigil [The Hijacked Revolution], Addis Abeba: Dinsho Printing Press, Hamle [July], 2019 Eth. C. The book is a true account according to insiders I was able to interview. It has not been refuted. In fact, it rattled Abiy Ahmed and his supporters to the extent that the book was subsequently bought back from the market at very high prices.

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‘Grey’s Anatomy’ Fans Still Can’t Handle This ‘Supergirl’ Shout-Out – Showbiz Cheat Sheet

Look! Up in the sky! Its a bird! Its a plane! Its a doctor from Seattle!

That reference makes no sense in a vacuum, but it makes perfect sense if you watch both Supergirl and Greys Anatomy and are hip to the fact that the second most important character on the show is played by Chyler Leigh, who was on Greys in a former life.

And this isnt even the first time the show has referenced one of its actors past work.

Sharp-eared Supergirl viewers on Reddit caught the reference on a recent episode when Leighs character was talking to another woman, who asks, So you were a doctor before you joined the FBI? Leighs character responds, I had a job, actually, up in Seattle for awhile.

That couldnt have been a coincidence, and viewers got a kick out of the in-joke, with one person making their own in-jokes: What made you leave Seattle? Was in shooting and then a plane crash Seattle! Well the plane crashed on the way away from Seattle Were you really a doctor Surgeon Specialty? It was going to be brains.

Then another person pointed out I just realized after seeing this post, her name is Alexandra Lexie Grey on Greys Anatomy and Alex Danvers on Supergirl. That one must be a coincidence. Probably? Either way, one other viewer finally saw the light, saying OMG NOW I REALISE WHERE I KNOW HER FROM!

Leigh had been on Greys Anatomy from 2007 to 2012 playing Lexie Grey, the half-sister of the main character Meredith Grey. The newer Grey earned the dubious distinction of being named the most pointless character on the show because, as one fan put it, All she did in the end was break up with Mark and then sleep with the next available guy until she died.

Lexie died a particularly traumatic death when she perished in a plane crash at the end of season 8. In real life, Leigh said she was leaving the show to spend more time with her family, and her departure wasnt one of the stormier ones that Greys Anatomy is rather infamous for. However, it wasnt long after she left Greys that she got the gig on Supergirl in 2015.

In the superhero show, Alex Danvers is the title characters adoptive sister in that her family took Kara Zor-El in after she crash-landed on Earth and helped her become Kara Danvers. When Kara decided to become a superhero, she joined forces with her sister, who is the director of a government agency that defends Earth from alien forces the kind Supergirl keeps tangling with.

Supergirl is played by Melissa Benoist, whom viewers met on Glee in 2012, when she was one of the new batch of kids that arrived at McKinley High School after the seniors graduated. Benoists character, Marley Rose, was a poor shy girl with a strong voice seen as a new Rachel, the Glee club star (Lea Michele), who had moved to New York City.

After Supergirl started in 2015, Benoist gave an interview to EW, (one where she references an eye injury that she later revealed was the result of domestic violence) where she was asked about doing a musical episode. She replied, Its kind of a running joke though because Im not the only one on the show that does. Jeremy Jordan is an amazing singer. Mehcad Brooks is a rapper. Chyler Leigh is a singer. I think David Harewood sings as well. Weve all joked that it would be funny. I dont know if the producers have seriously thought about it.

Eventually, they did. Grant Gustin, who plays the Flash on Supergirls sister show, had also appeared on Glee. This led to a crossover Flash episode that gave Benoist and Gustin excuses to sing. Benoist sang the standard Moon River while she and Gustin at the hands of a villain called The Music Meister, who was played by Darren Criss, another Glee veteran.

Leigh hasnt sung on Supergirl, but she did sing Anna Nalicks Breathe (2 AM) on the musical episode of Greys.

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'Grey's Anatomy' Fans Still Can't Handle This 'Supergirl' Shout-Out - Showbiz Cheat Sheet

Popescu works to empower faculty, foster inclusivity as chair of national group – UB Now: News and views for UB faculty and staff – University at…

Gabriela K. Popescu, professor of biochemistry in the Jacobs School of Medicine and Biomedical Sciences at UB, has been elected chair of the Council of Faculty and Academic Societies (CFAS) of the Association of American Medical Colleges (AAMC).

Popescu, a UB faculty member since 2006 and a UB alumna, began her two-year term as CFAS chair on Nov. 13 and will serve until Nov. 9, 2021, when she will become immediate past chair. As CFAS chair, she will serve as a member of the AAMCs board of directors until November 2021.

The AAMC represents the nations medical schools and teaching hospitals, and is dedicated to transforming health care through innovative medical education, cutting-edge patient care and groundbreaking medical research.

I am honored to step into this new role, Popescu says.

This year, she plans to engage and lead the CFAS Administrative Board in an overall evaluation of current activities, to identify areas of success and to find ways to more effectively serve as a voice for the faculty members the group represents.

CFAS formed in 2013 at the request of faculty who had formerly been active in the AAMCs Council of Academic Societies, with the goal of more directly engaging and representing faculty views and issues, and voicing them to the AAMC to help shape the development and implementation of its programs and policies.

As the largest of the AAMC councils, CFAS represents more than 173,000 full-time faculty with 350 faculty members, two representatives from each AAMC member school and society.

Popescu initially served on the administrative board, representing the Jacobs School. In 2017, she was named chair-elect and her primary responsibility was to chair the committee that organizes the annual CFAS spring meeting.

Last spring, she and CFAS colleagues organized what she calls a tremendously effective plenary session on sexual harassment in academic medicine and one of a few pioneering sessions held at national meetings on the subject. The session included opportunities for participants to learn and practice new skills designed to disrupt unconscious bias and to foster a more inclusive climate for women.

As CFAS chair for the next two years, she says, it will be important to continue to chisel the identity of this relatively new council, to engage and empower faculty representatives to speak loudly and effectively to the most critical issues facing academic medicine, and to foster a culture of inclusivity and appreciation.

Popescu believes that her experiences as a bench scientist, as a woman in academic medicine and as an immigrant serve her well in this leadership position.

Specifically, I feel that at this particular juncture, when the gender composition of our student body for the first time in history matches that of our nations population, it is important to commit ourselves to advancing and achieving equity along the entire career span of scientists and physicians, and across the spectrum of disciplines and specialties, she says.

Popescu points out that as a bench scientist, she is a representative of what is arguably the smallest of the three traditional tracks in academic medicine, the others being educators and clinicians.

Scientists here in the Jacobs School, like many others in academic medicine, have felt the specter of reduced National Institutes of Health funding and budgetary cuts for research amid talk of the high cost that basic research imposes on medical schools, she says.

My CFAS colleagues have mobilized under this threat and have been instrumental in demonstrating the value that science brings to the mission of medical schools, she continues. With this evidence from the trenches, the AAMC partnered with many others to make a successful case for the profitable investment that scientific discoveries represent for medicine. Today, bipartisan legislatures support predictable and sustainable funding for the NIH, and many scientists at the Jacobs School and across the country receive federal funds to push the boundaries of knowledge.

Popescu currently directs research funded by three NIH awards totaling more than $3.5 million. She has invested much of her career studying afamily of brain receptors called NMDA (N-methyl-D-aspartate) receptors that are critical to learning and memory. Her research on these receptors may lead to more effective strategies to treat a range of neurological and neurodegenerative conditions, from stroke, chronic pain and addiction to disorders such as schizophrenia and epilepsy.

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Trying to read the ‘mind of a group’ shapes our decisions online – Futurity: Research News

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Using a mathematical framework with roots in artificial intelligence and robotics, researchers have uncovered the process for how people make decisions in groups.

The researchers also found they could predict a persons choice more often than more traditional descriptive methods.

In large groups of essentially anonymous members, people make choices based on a model of the mind of the group and an evolving simulation of how a choice will affect that theorized mind, the study finds.

Our results are particularly interesting in light of the increasing role of social media in dictating how humans behave as members of particular groups, says senior author Rajesh Rao, a professor in the University of Washingtons Paul G. Allen School of Computer Science & Engineering and co-director of the Center for Neurotechnology.

We can almost get a glimpse into a human mind and analyze its underlying computational mechanism for making collective decisions.

In online forums and social media groups, the combined actions of anonymous group members can influence your next action, and conversely, your own action can change the future behavior of the entire group, Rao says.

The researchers wanted to find out what mechanisms are at play in settings like these.

In the paper, they explain that human behavior relies on predictions of future states of the environmenta best guess at what might happenand the degree of uncertainty about that environment increases drastically in social settings. To predict what might happen when another human is involved, a person makes a model of the others mind, called a theory of mind, and then uses that model to simulate how ones own actions will affect that other mind.

While this act functions well for one-on-one interactions, the ability to model individual minds in a large group is much harder. The new research suggests that humans create an average model of a mind representative of the group even when the identities of the others are not known.

To investigate the complexities that arise in group decision-making, the researchers focused on the volunteers dilemma task, wherein a few individuals endure some costs to benefit the whole group. Examples of the task include guarding duty, blood donation, and stepping forward to stop an act of violence in a public place, they explain in the paper.

To mimic this situation and study both behavioral and brain responses, the researchers put subjects in an MRI, one by one, and had them play a game. In the game, called a public goods game, the subjects contribution to a communal pot of money influences others and determines what everyone in the group gets back. A subject can decide to contribute a dollar or decide to free-ridethat is, not contribute to get the reward in the hopes that others will contribute to the pot.

If the total contributions exceed a predetermined amount, everyone gets two dollars back. The subjects played dozens of rounds with others they never met. Unbeknownst to the subject, a computer mimicking previous human players actually simulated the others.

We can almost get a glimpse into a human mind and analyze its underlying computational mechanism for making collective decisions, says lead author Koosha Khalvati, a doctoral student in the Allen School. When interacting with a large number of people, we found that humans try to predict future group interactions based on a model of an average group members intention. Importantly, they also know that their own actions can influence the group. For example, they are aware that even though they are anonymous to others, their selfish behavior would decrease collaboration in the group in future interactions and possibly bring undesired outcomes.

In their study, the researchers were able to assign mathematical variables to these actions and create their own computer models for predicting what decisions the person might make during play. They found that their model predicts human behavior significantly better than reinforcement learning modelsthat is, when a player learns to contribute based on how the previous round did or didnt pay out regardless of other playersand more traditional descriptive approaches.

Given that the model provides a quantitative explanation for human behavior, Rao wonders if it may be useful when building machines that interact with humans.

In scenarios where a machine or software is interacting with large groups of people, our results may hold some lessons for AI, he says. A machine that simulates the mind of a group and simulates how its actions affect the group may lead to a more human-friendly AI whose behavior is better aligned with the values of humans.

The results appear in Science Advances.

Additional coauthors are from UC Davis; New York University; and the Institut des Sciences Cognitives Marc Jeannerod. The National Institute of Mental Health, the National Science Foundation, and the Templeton World Charity Foundation funded the work.

Source: Jake Ellison for University of Washington

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Trying to read the 'mind of a group' shapes our decisions online - Futurity: Research News

Treating autism, severe behavior and addiction – Rowan Today

In Rowan Universitys Center for Behavior Analysis, professors who are Board Certified Behavior Analysts (BCBA-D) and their students take on difficult problems of human concern across diverse populations, needs, and settings.

Each week, they spend hours striving to teach a nonverbal child as young as two to communicate. In specially equipped rooms, therapists don protective equipment to work with children whose severe behavior extends to harming themselves or others. They find ways to help users finally quit smoking for good.

In the center, the lines between education, research and service often blur, in all the best ways. Rowan students provide services to community members as part of the training and research that will inform the future of behavior analysis.

Understanding behavior analysis

"Most people dont really know what behavior analysis is, said Dr. Mary Lou Kerwin, professor of psychology and executive director of the Center for Behavior Analysis, located in Robinson Hall. Behavior analysis is the use of scientific principles to explain and change behavior.

Unfortunately, the use of behavioral principles is so ubiquitous that people often assume they understand how to use these strategies effectively. But behavior analysis is actually complex.

If you understand how an individual behaves, you can predict future behavior, Kerwin explained. That provides potential for social change in society in general, and we can improve quality of life at the individual levels.

Humans are complicated, said Dr. Bethany Raiff, associate professor and director of the Health and Behavioral Integrated Treatments (HABIT) Research Unit, and one of the most complicated things is trying to figure out why people do what they do.

Building a better quality of life for children with autism

Much of the work done in the Center for Behavior Analysis involves treating children with autism spectrum disorder (ASD).

The centerprovidesaffordable treatment and education to the parents of children with autism, said Jacqueline Logan, BCBA and research coordinator at the center. Besides benefitting from the variety of different assessments and individualized treatments offered through the center, the children and their families are participating in research that will help advance the field as a whole.

What we know from over 25 years of research is that the earlier the intervention is provided, the better the outcome for the child, Kerwin explained. That intervention is often intensive, taking so many hours each week that it's not always feasible to use more than one type of intervention. Thats why its crucial that the intervention used is the most effective option possible.

A lot of interventions have no empirical support but sound good to parents who are desperate to help their child, Kerwin said. Interventions based on behavior analysis, however, do have empirical support. One remaining question with these interventions is which behavior analytic interventions work best for whom and when.

Children with autism spectrum disorder all have different needs and different deficits. Although the myth that autism manifests in the same way in every child was debunked years ago, treatment has continued to be one-size-fits-all, Kerwin explained.

If we're engaging in hours and hours of something that's not effective, were missing the opportunity to do something that is effective, potentially limiting a child's ability to improve over time, Kerwin said.

Autism intervention approaches go head-to-head in grant-funded SMART study

Evaluating the efficacy of different interventions is the focus of the SMART (Sequencing for Maximizing Acquisition and Response to Treatment) study Dr. Michelle Soreth, associate professor of psychology, is leading with co-investigator Kerwin. The goal is to maximize that ability to improve communication skills over time for children participating in the study as well as ultimately for other children with ASD.

Soreth and Kerwin initially tested applied behavior analysis (ABA) interventions against a non-ABA form of intervention called Relationship Development Intervention (RDI). This research was conducted under the first of two grants awarded by the New Jersey Governors Council for Medical Research and Treatment of Autism and the New Jersey Department of Health. The outcomes of their interventions showed that parent-implemented ABA was a particularly powerful tool in the treatment of autism.

What this first study did not do was establish which types of treatments within the field of ABA were the most effective. Thats the goal of Soreth and Kerwins current research, funded by a second grant from the Department of Health, which pits the original model of ABA-based early intervention for autism, Discrete Trial Instruction (DTI), against a newer ABA-based intervention model known as the Verbal Behavior Approach (VBA).

Although researchers are just finishing data analysis, preliminary findings indicate that children in the VBA group learned new skills at twice the rate of children in the DTI intervention group.

Given that one of the best indicators of overall prognosis for children diagnosed with autism is whether the child is speaking in phrases before age five, its almost as though we are working against the clock, explained Soreth, who focuses primarily on the significance of intervention with children as young as two years of age.

If we are able to identify interventions that double the rate of progress during such a critical learning period, imagine the possibilities for improving the overall prognosis and quality of life for individuals diagnosed with autism, Soreth added.

Addressing severe behavior SAFE-ly

Dr. Christina Simmons, assistant professor of psychology, specializes in treating populations others might shy away from because of their severity. In her Social Acceptability and Functional Evaluation of Behavior (SAFE Behavior) Lab and Severe Behavior Clinic, she works with school-aged children from three to 18 who exhibit severe behavior, such as aggression, property destruction, and self-injurious behavior. Many of these children present with autism and other developmental disabilities.

Simmons embraced this work early on in her academic career. As an undergraduate working with a nonverbal 13-year old with autism, Simmons gained insight into why the child would destroy property and, at times, resort to self-injurious behaviors.

She was trying to communicate with her destructive behaviors, Simmons said. Thats when I discovered ABA as an evidence-based approach for treating severe behavior.

The goals she and the students working under her supervision have are pretty clear-cut: reducing challenging behaviors and developing appropriate functional skills. How to accomplish those objectives is trickier.

"How do we promote meaningful change, not just in clinical environments but also in the childs natural environment? asked Simmons.

Theres no one answer that works for all children and all scenarios. But, for now, Simmons and her students are working to improve the assessment and treatment process to promote socially meaningful outcomes. All of my research is applied, said Simmons. In addition to my research lab, I work closely with graduate students in practicum and undergraduate students gaining fieldwork hours.

The students are eager to learn, especially in a unique environment like the Severe Behavior Clinic, and families get high-quality and enthusiastic helpa genuine win-win.

Behavioral economics and healthy choices

With her HABIT lab, Raiff demonstrates that behavior analysis has applications for adults as well as children. She specializes in a field known as behavioral economics.

I try to understand how people make choices and how to shift decisions towards healthier choices, she explained. Better health choices often result in delayed rewards, whereas unhealthy choices often result in immediate rewards.

When those unhealthy behaviors win out, its because the immediate benefit is more powerful than the potential benefit of better health later. Whether youre picking junk food over a healthy salad for reasons like taste or time, or binge watching a show over going to the gym, youre making a choice.

In the field of behavioral economics, its often easy to figure out what drives people to choose the unhealthy behavior. The more difficult task is discovering effective ways to alter that behavior.

Incentives that are arranged and delivered immediately much like those immediate rewards of making unhealthy choices can shift choices toward healthy behavior, Raiff said.

The use of financial incentives, sometimes called contingency management, has proven effective in helping people quit smoking and give up drugs. Of course, theres a problem with this traditional type of reward: it costs money.

Raiff is researching other, more sustainable methods of applying these immediate reward systems. Competition tends to be a big motivator. She recently received a grant from the National Institutes of Health to research the efficacy of another form of incentive: video game rewards.

We want to see if the virtual rewards earned in a mobile game help induce abstinence from smoking, she said. Were paving the way to make a more affordable option. The video game has great potential and is really different from anything else out there for smoking cessation.

Raiffs work is ongoing, but she and her team are making great strides.

Were not there yet in terms of execution but, through testing, were learning a lot about what kinds of games are effective and how to keep users engaged, she said. We definitely have found an interest among users.

Raiff also is collaborating with physicians at Cooper University Hospital on two Camden Health Research Initiative grants awarded by Rowan University. Shes beginning to test contingency management interventions to increase treatment adherence among individuals diagnosed with opioid use disorder and to initiate smoking abstinence among individuals diagnosed with schizophrenia spectrum disorder.

Where research meets service

Research and service to the community are two of the three principles on which the Center for Behavior Analysis was founded. Theres a critical need, said Simmons of the service component. Especially in our area, there are not sufficient intensive services for children with severe behavior concerns.

Service to the community can take many forms. Although families can come in to receive treatment through outpatient clinics in Robinson Hall, the University also coordinates with the county care management organizations in the statewide Childrens System of Care (CSOC). Answering the states Request for Qualified Providers (RFQ) for more than two years, faculty, undergraduate and graduate students and alumni involved in the Center for Behavior Analysis offer intensive in-home behavioral services (IIH) and Individual Support Services (ISS) for children with intellectual disabilities in their own homes.

These services give both our undergraduate and graduate students a unique opportunity to work directly with children with developmental disabilities who have complex behavioral needs under the supervision of our faculty and alumni, said Simmons, who, along with her students, is highly involved in these in-home services. Through these experiences, they gain valuable clinical skills and confidence to work with this specialized population after graduation from our programs.

An extraordinary opportunity for students of behavior analysis

What of that third principle of the center? Education doesnt take a backseat to research and service. Instead, its a unique curriculum, along with these research and service opportunities, that makes Rowans undergraduate and graduate programs in Behavior Analysis stand out.

Rowan is a hotbed of behavior analytic activity, said Kerwin. In our discipline, everyone knows where Rowan is. Undergraduate coursework available through the Department of Psychology prepares students to become Board Certified assistant Behavior Analysts (BCaBA), and the schools graduate programs can lead to the Board Certified Behavior Analyst (BCBA) credential.

The Center for Behavior Analysisprovided mehands-on training and knowledge, not only throughresearch practices but throughapplied techniques used in the field of Applied Behavior Analysis, said Logan, who completed her Master of Arts in Behavior Analysis degree in 2018. I was ableto work closelywith myprofessors toreceive feedback and training that gave me the skills to become a Board CertifiedBehavior Analyst.

Studies in applied behavior analysis can equip students with the skills to work with these same patient populations after graduation. This coursework can also prepare them to translate the skills of behavior analysis to work with a broad range of individuals in a variety of settings.

The principles can be applied in so many ways, from medical uses such as teaching child patients to stay still in an MRI machine and swallow pills to applications in organizational behavior management, said Kerwin. We anticipate that the scope of research in the Center for Behavior Analysis will continue to expand as the true potential of behavior analysis as a broad health profession begins to be fully recognized.

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Treating autism, severe behavior and addiction - Rowan Today

After Year Of Record Grizzly Bear Deaths, Managers Talk Human-Bear Conflict Reduction – MTPR

After Year Of Record Grizzly Bear Deaths, Managers Talk Human-Bear Conflict Reduction

The last two years have been the deadliest on record for grizzlies in and around Glacier National Park. There have been at least 48 grizzly mortalities this year in the area, called the Northern Continental Divide Ecosystem (NCDE). As grizzly mortalities mount, bear managers in northwest Montana are trying to tackle the sources of rising deaths.

At a year-end meeting of bear managers on Tuesday, state bear biologist Cecily Costello said those numbers are nothing to worry about yet.

"Right now, Im not willing to say that two years of increased mortality is a trend. But I also am not gonna say that its not a trend. So Im just gonna have to say we wait and see what happens."

Costello says the population is still healthy and growing at over 1,000 bears. She says those 48 mortalities still fall below a state threshold for the ecosystem passed last year.

"At the same time that you can hear the number and be sad, you can also kind of celebrate in the fact that that many bears could die and we still have a viable population."

The grizzlies range is growing along with their population. Now, more private land is occupied by grizzly bears than public land. That leads to conflicts with property and livestock. So Costello says that high death rate, "may have a lot to do with the bear population, but it may have a lot do with us, as well."

Costello says human development and recreation have been on the rise. Citing a Headwaters Economics study from last year, she says between 1990 and 2016, nearly 300,000 acres of open space was converted to housing, and 30,000 new homes were built in the 9 counties that surround the Glacier region. She also says the number of cars entering the Park has nearly doubled since 2000.

Although Costello says heightened mortalities arent yet a risk to the grizzly population, bear managers are working to reduce the number of deaths. An interagency working group of federal, state, and tribal officials presented recommendations to address grizzly mortality at the meeting.

Hilary Cooley, grizzly bear recovery coordinator for the U.S. Fish and Wildlife Service, says she expects conflicts to continue to expand as human population and recreation continue to rise.

"These are tough issues, and its not gonna be enough to spend a few phone calls here working on these topics, and expect to have any change. We want to drop mortalities and drop conflicts," Cooley says.

Cooley identified hunters, roads, trains, chickens and trash as the primary drivers of conflict, based on trends over the last two decades. She presented recommendations to address each issue.

Trains killed eight grizzlies in Montana this year.

"This was a spike," Cooley says.

Train deaths have actually gone down since 1999, compared to the decade before it.

Cooley also says that cattle and sheep depredations, and conflicts over beehives have gone down over the same time period. However, other conflicts especially over chickens have skyrocketed.

Solutions ranged from education, outreach and collaboration, to intensive road projects that could help grizzlies safely pass through traffic, to formal regulations that could change human behavior. Across the board, funding was a key barrier to implementation. Cooley expects many of these recommendations to be implemented by 2021.

Grizzlies in the lower 48 were listed as threatened under the Endangered Species Act in 1975. In the Glacier area, state and federal biologists say the bears have recovered. At the meeting, State Sen. Bruce Gillespie says those bears have been federally protected long enough.

"Lets promote a model that gets the grizzly bear delisted, hopefully by next year, and on to a management plan."

In public comment, citizens addressed human safety issues, took issue with U.S. Forest Service projects that compromised bear habitat, and said grizzlies have a long way to go to reach meaningful recovery.

Josh Osher is the Montana Director for the conservation group, the Western Watersheds Project.

"Within a tiny little period of history they were shrunk to almost nothing," Osher said. "So I dont see 44 years as all that long to think about in term of the time it takes to recover a species."

The Interagency Grizzly Bear Executive Committee will hold its year-end meeting, which will address mortality and other issues across all grizzly ecosystems, on December 16 at the Residence Inn in Missoula.

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After Year Of Record Grizzly Bear Deaths, Managers Talk Human-Bear Conflict Reduction - MTPR

Why People Skills Are Essential In PR And How To Improve Them – Forbes

Public relations professionals are in the business of not only getting exposure for their clients, but of making clients and journalists happy.

You can be the best public relations (PR) expert in the world, but if you lack people skills, youll never be truly successful. In PR, you have to understand human behavior and emotions, both in terms of your clients and the people you pitch to.

PR pros need to be jacks-of-all-trades. You have to be a master at writing, researching, communicating and organizing. But career success goes beyond the skills you learned in college. In fact, the key to good PR is something you learned in kindergarten: people skills.

Why Do PR Pros Need People Skills?

Degrees, certifications and a track record of successful campaigns will get you far in PR, but nothing works as well as people skills. People skills, like listening and compassion, are soft skills that are hard to measure, to be sure, but that doesnt mean they arent important.

In fact, in Ed Zitrons book This Is How You Pitch, he argues that PR success doesnt come from high-profile features. It comes from fostering long-term relationships with reporters. When youre good at making friends, you build a professional network of genuine, helpful relationships. Once its time to pitch your story, you have a swath of people to send that pitch to.

Think about it: If you got a pitch from a total stranger and a another from a good buddy who you grabbed a coffee with last week, which pitch would you choose? Chances are, youre going to go with the person you know.

If you arent getting responses to your pitches, theres a good chance its because you dont have an in with that journalist. But when you develop your people skills and grow professional relationships, you can score more media placements for your clients. On top of that, youll also be better at managing client relationships, ensuring repeat business and a loyal customer base. Its a win-win!

Three Methods To Improve Your People Skills

As humans, we learn people skills when were children. But just because were all grown up doesnt mean weve stopped learning. Follow these three tricks to improve your people skills and become a better PR professional.

1. Improve your emotional intelligence.

Believe it or not, humans make most decisions based on emotion, not logic. By improving your emotional intelligence, youll be able to connect to journalists, your clients and even the public on a more effective level.

Emotional intelligence is the awareness of emotions and how those emotions affect behavior. For example, with a healthy sense of emotional intelligence, you can sense when an editor is stressed out. You might wait to pitch them until you have their undivided attention.

In any situation, try to identify the other partys emotions. Ask why theyre feeling that way, how it affects their behavior and how your behavior will influence their emotions. At the end of the day, this comes down to having compassion for other people and using that sense of compassion to pitch smarter.

2. Listen!

You arent listening to me! has to be one of the most common sentences in the English language. Instead of being quick to speak, be quick to listen. Its not enough to hear what someone is telling you. Listening is an essential people skill thats about committing what someone says to memory, processing it and drawing conclusions. Its the single best way to show someone you care.

For example, if you dont follow a journalists instructions for a pitch, theyre going to be frustrated with you. Its going to look like you didnt listen. You may come off as tone deaf, and it will potentially ruin your chances of ever getting a media feature.

The next time youre chatting with someone, stop thinking about what youre going to say next. Theyre telling you what they need; all you have to do is listen.

3. Maintain relationships.

Relationships are like your bank account. You have to put money into that account regularly, and only occasionally make withdrawals. If you want to ask a journalist for a favor, you have to put more into the relationship than youre taking out of it. That means maintaining relationships and hanging out with a contact when you dont need anything.

This is easier said than done, especially if you know a lot of people in the media. To do regular outreach without losing your mind, set a calendar appointment twice a week to grab coffee with one of your contacts. Youll have a chance to catch up with people without asking for something in return. Chances are, once you send in a pitch, theyll be more than happy to help out because youve invested in the relationship.

The Bottom Line

If youre pitching stories to humans, you need to understand them. Thats why people skills are so important to the art of PR. By nurturing relationships within your network, youll have a trusted list of journalists you can pitch to score more stories. Your clients will benefit from your improved people skills, too.

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Why People Skills Are Essential In PR And How To Improve Them - Forbes

A Genetic Network Sheds Light on the Evolution of the Modern Human Face – Technology Networks

The study, published inScience Advances, results from the collaboration between a UB team led by Cedric Boeckx, ICREA professor from the Section of General Linguistics at the Department of Catalan Philology and General Linguistics, and member of the Institute of Complex Systems of the UB (UBICS), and researchers from the team led by Giuseppe Testa, lecturer at the University of Milan and the European Institute of Oncology.

An evolutionary process similar to animal domestication

The idea of human self-domestication dates back to the 19th century. It is the claim that anatomical and cognitive-behavioral hallmarks of modern humans, such as docility or a gracile physiognomy, could result from an evolutionary process bearing significant similarities to the domestication of animals.

The key role of neural crest cells

Earlier research by the team of Cedric Boeckx had found genetic similarities between humans and domesticated animals in genes. The aim of the present study was to take a step further and deliver empirical evidence focusing on neural crest cells. This is a population of migratory and pluripotent cells - able to form all the cell types in a body - that form during the development of vertebrates with great importance in development. "A mild deficit of neural crest cells has already been hypothesized to be the factor underlying animal domestication. Could it be that humans got a more prosocial cognition and a retracted face relative to other extinct humans in the course of our evolution as a result of changes affecting neural crest cells?" asks Alejandro Andirk, PhD students at the Department of Catalan Philology and General Linguistics of the UB, who took part in the study.

To test this relationship, researchers focused on Williams Syndrome disorder, a specific human neurodevelopmental disorder characterized by both craniofacial and cognitive-behavioral traits relevant to domestication. The syndrome is a neurocristopathy: a deficit of a specific cell type during embryogenesis. In this case, neural crest cells.

In this study, researchers from the team led by Giuseppe Testa used in vitro models of Williams syndrome with stem cells derived from the skin. Results showed that the BAZ1B gene -which lies in the region of the genome causing Williams Syndrome- controls neural crest cell behavior: lower levels of BAZ1B resulted in reduced neural-crest migration, and higher levels produced greater neural-crest migration.

Comparing modern human and Neanderthal genomesResearchers examined this gene in archaic and modern human genomes. "We wanted to understand if neural crest cell genetic networks were affected in human evolution compared to the Neanderthal genomes", Cedric Boeckx said.

Results showed that that BAZ1B affects a significant number of genes accumulating mutations in high frequency in all living human populations that are not found in archaic genomes currently available. "We take this to mean that BAZ1B genetic network is an important reason our face is so different when compared with our extinct relatives, the Neanderthals," Boeckx said. "In the big picture, it provides for the first time experimental validation of the neural crest-based self-domestication hypothesis," continues.An empirical way to test evolutionary claims

These results open the road to studies tackling the role of neural crest cells in prosociality and other cognitive domains but is also one of the first examples of a potential subfield to test evolutionary claims. "This research constitutes one of the first studies that uses cutting-edge empirical technologies in a clinical setting to understand how humans have evolved since the split with Neanderthals, and establishes Williams Syndrome in particular as a unique atypical neurodevelopmental window onto the evolution of our species," Boeckx concludes.

Reference: Zanella et al. 2019.Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication. Science Advances.DOI: 10.1126/sciadv.aaw7908.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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A Genetic Network Sheds Light on the Evolution of the Modern Human Face - Technology Networks