DNA Genetics Announces Agreement With Green Peak To Make The Most Of Michigan Adult-Use Cannabis Market – Yahoo Finance

OG DNA Genetics recently disclosed a licensing agreement in conjunction with Green Peak Innovations, a medical cannabis producer and distributor in the Michigan market.

This arrangement will concede Green Peak Innovations consent to the DNA brand and access to their genetics portfolio for use at the companys cannabis cultivation and processing plant in Harvest Park, Michigan. Additionally to growing DNA genetics, Green Peak has entered the retail sector, with several locations around the state.

The recent permit of adult-use cannabis police in Michigan will enable Green Peak to supply recreational and medical users high-quality strains.

Want to hear exclusive updates on the adult-use licensing process? Check out the next meetup with MRA Executive Director, Andrew Brisbo on Dec. 18 at the Benzinga Headquarters! Get your tickets here before they sell out!

"By partnering with Green Peak Innovations, we position ourselves to expand into the rapidly developing Michigan cannabis market alongside a proven and trusted cannabis producer and distributor," said Charles Phillips, CEO of DNA Genetics.

Jeff Radway, CEO of Green Peak Innovations said, "We appreciate what DNA has accomplished for the cannabis industry and are excited to partner with them. We believe that by incorporating DNAs library of best-in-class cultivars and award-winning genetics into our facility, we can further enhance our ability to deliver the highest-quality products to Michigan and eventually the entire United States."

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DNA Genetics Announces Agreement With Green Peak To Make The Most Of Michigan Adult-Use Cannabis Market - Yahoo Finance

DNA Genetics Announces Strategic Partnership With Green Peak Innovations Signaling Their Entry Into the Michigan Medical and Adult Use Cannabis…

LOS ANGELES, Dec. 10, 2019 (GLOBE NEWSWIRE) -- OG DNA Genetics (DNA or the Company), a globally recognized leading cannabis brand, today announced a licensing agreement (the Agreement) with Green Peak Innovations (Green Peak or GPI), the leading producer and distributor of medical and adult-use cannabis in the Michigan market.

This Agreement will grant Green Peak Innovations license to the DNA brand and access to their proprietary library of award-winning genetics for use at the companys state-of-the-art, 73,000-square-foot cannabis cultivation and processing facility in Harvest Park, Michigan. In addition to cultivating DNA genetics, Green Peak has expanded its vertically integrated business to include premium retail stores, with locations currently open around the state. The recent passage of adult-use cannabis laws in Michigan will allow Green Peak to offer recreational and medical consumers the highest quality strains in the market.

By partnering with Green Peak Innovations, we position ourselves to expand into the rapidly developing Michigan cannabis market alongside a proven and trusted cannabis producer and distributor, said Charles Phillips, CEO of DNA Genetics. Green Peak Innovations commitment to best practices, the highest-quality products and emphasis on integrity perfectly align with what we look for in potential licensing partners.

For more than 15 years, genetics developed by DNA have won more than 200 awards in all categories at the most prestigious cannabis events around the world, making DNA the global standard in breeding and growing truly best-in-class strains. These awards include the High Times Top 10 Strain of the Year, which was inducted into The High Times seedbank hall of fame in 2009, the High Times 100 list of the most influential people in the industry and theHigh Times Trailer BlazersAward, for contributions made towards uniting the fields ofentrepreneurship, politics and medicine.

We appreciate what DNA has accomplished for the cannabis industry and are excited to partner with them. We believe that by incorporating DNAs library of best-in-class cultivars and award-winning genetics into our facility, we can further enhance our ability to deliver the highest-quality products to Michigan and eventually the entire United States, said Jeff Radway, CEO of Green Peak Innovations.

Consumers in Michigan can expect to see DNA genetics available in Green Peaks Skymint-branded retail stores and via provisioning centers around the state under the companys North Cannabis wholesale brand as soon as Summer 2020.

About OG DNA Genetics Inc.

DNA was rooted in Los Angeles and founded in Amsterdam in 2004 by Don Morris and Aaron Yarkoni. Over the last decade, the Company has built and curated a seasoned genetic library and developed proven standard operating procedures for genetic selection, breeding, and cultivation. In a world that is increasingly opening up to commercial cannabis activity, DNA is positioned to become the first, truly geographically-diversified company with multiple partnerships with top-licensed producers and brands that have built their companies and global presence utilizing the Powered by DNA model. For more information, please visit http://www.dnagenetics.com.

For further information, please contact Rezwan Khan, Vice President, Global Corporate Development at rezwan@dnagenetics.com

About Green Peak Innovations

Green Peak Innovations is Michigans leading vertically integrated cannabis company and the states largest medical and recreational license holder. With two state-of-the-art indoor grow facilities, the company cultivates, processes, markets and distributes a full range of branded cannabis products, including Skymint, North Cannabis, Jolly, Evoxe Laboratories, Agata and St. Jade. GPI products can be found at the companys Skymint provisioning centers and via the North brand, retailers around Michigan through a robust wholesale network.

As purveyors of premium-crafted cannabis, weve developed a portfolio of the finest cannabis brands available for daily wellness, healing or just getting high on life. GPI inspires individuals to UNLOCK their mental, physical and spiritual potential through cannabis.

For more information, visit http://www.greenpeakinnovations.com.

Media Contact: Jordan Walker, jwalker@identitypr.com.

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DNA Genetics Announces Strategic Partnership With Green Peak Innovations Signaling Their Entry Into the Michigan Medical and Adult Use Cannabis...

Effects of sleep deprivation and tips to follow to sleep well – Republic World – Republic World

A 2019 study by the University of Colorado Boulder, published in the Journalof Experimental Physiology, proposed a new potential mechanism through which one can trace howsleepinfluences an individualshearthealthand overall physiology.The study states that people who do not get 7 hours ofsleepat night often suffer from lower blood levels of microRNAs that play a key role in maintaining vascularhealth.Through time, while such studies have led to the discovery that people who do not get enoughsleepare at a greater risk of experiencing a stroke orheartattack. There is an increased risk of cardiovascular disease and death in persons whosleepless than 6 hours every day than those whosleepmore.Dr Santosh Kumar Dora, Senior Cardiologist, Asian Heart Institute, Mumbai lists effects of sleep deprivation and tips to sleep well.

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The effect of acutesleepdeprivation results in cognitive impairment, which includes deficits in behavioural alertness and vigilant attention, lack of logical reasoning, errors in simple tasks, accidents, poor work performance, poor mood, irritability, low energy, decreased libido and poor judgement.On the other hand, chronicsleepdeprivation (CSD) results in accidents, workplace errors, inappropriate drowsiness and unplanned naps with consequences both at home and at the workplace.

One must thus cultivate healthysleepinghabits for a healthyheart, never underestimating the importance of a good nightssleep. The prescribed duration ofsleepis nothing less than 7 to 9 hrs. The depth ofsleepis as important as its duration as this happens to be the time when the body undergoes repair, restoration and rest.

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The following are a few tips to help yousleepwell:

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Disclaimer: The content provided above is for information purposes. This is no way intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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Effects of sleep deprivation and tips to follow to sleep well - Republic World - Republic World

The Outer Line: The impact of endurance training on the cardiac health of women – VeloNews

Female cyclists are at a lower risk of suffering Sudden Cardiac Death than male athletes, but women should still learn about ways to screen for heart problems before engaging in endurance sports.

Dr. Mehreen Quhreshi is a cardiologist with advanced training in stress testing and cardiac imaging from Columbia University Medical Center in New York. She practices in Harrisburg, Pennsylvania and serves as the director of the Preventative Cardiology Program and the Nuclear Stress Lab at UPMC Pinnacle Heart and Vascular Institute. Dr. Bill Apollo, an amateur bike racer, runner, and duathlete is a Harrisburg, Pennsylvania-based cardiologist, who directs the UPMC Pinnacle Sports and Exercise Cardiology Clinic.

At the Paris Olympics in 1900, endurance sports were exclusively dominated by men; a mere 22 women participated, competing in the five gentrified events of croquet, equestrian, golf, tennis, and sailing. It took until the latter half of the twentieth century for the world to witness women competing in major Olympic endurance sports such as cycling (Los Angeles, 1984) and triathlon (Sydney, 2000).

Wider womens participation in the Olympics roughly coincided with the establishment of Title IX of the United States Educational Amendments of 1972, which mandated equal access for women in any program that received Federal funding including sports in public schools and universities. These two major developments fueled an explosion of female participation in a variety of events at all skill levels. The percentage of women finishers in marathons in the U.S. rose from only 10% in 1980 to a robust 45% by 2015. Women set a new record for Olympic participation at the 2016 Rio Olympics, with nearly equal numbers (5,176 athletes, or 45% of total), and with representation in all events included in the games.

Paradoxically, women have generally been under-represented in medical research studies looking at cardiac health, adaptation to endurance training and its potential consequences. Despite this surge of female athletic participation, we still havent achieved gender equality when it comes to understanding and caring for the female athletes heart. And recent small-scale studies suggest that there are in fact important cardiac differences between the sexes.

Some of the key questions are: to what extent do underlying genetic and hormonal factors impact normal changes in a womans heart related to exercise? How do these influences alter her risk for developing chronic heart problems or sudden cardiac death during competition? Are women better equipped to handle endurance training by design? Some recent research suggests that pregnancy subjects the female body to cardiac stresses similar to those that male athletes experience in even the most competitive events, including events like the Tour de France.

Below we examine the current understanding of cardiac development and risks in women endurance athletes, how and why women may differ from men in this regard, and recommended precautions that should be taken in training and competition by elite female endurance athletes.

Sudden cardiac death (SCD) during athletic competition is fortunately a rare occurrence, and it tends to affect men more commonly than women. In fact, a womans risk of SCD during endurance sports is estimated to be some 10 times lower than for her male colleagues. Professional cycling, during the past 3 seasons, has seen a total of 6 elite men tragically die directly from heart problems during races (5 in road racing, 1 on the track), with the most recent being Robbert de Greef in March 2019. During the same time period, there were zero incidents involving women, and indeed there are no known reports of SCD during elite womens cycling events for the past 20 years. Professional female cyclists are far more likely to die from training accidents (usually involving automobile collisions) than from heart problems.

Interestingly, these observations regarding SCD in cycling seem not to be true for other endurance sports. Marathon running has a huge participant base much larger than the womens pro peloton with nearly a half million participants in 2019 alone. This huge statistical sampling clarifies the measure of SCD risk: 1 incident per 150,000 participants overall, but more commonly occurring in men (1/ 100,000), and much less likely to occur in women (1/243,000).

Despite this fairly low risk of SCD in women, the sheer volume of running participants makes it easier to find reports of SCD. For example, Taylor Ceepo, age 22, died in May 2019 less than 1 mile from the finish line at the Rite-Aid Cleveland Marathon. The medical examiners report indicated that Ceepo experienced sudden cardiac death in association with physical exertion, pseudoephedrine use (a fairly benign over-the-counter decongestant) and cardiomyopathy. Her tragedy should remind us that even in very young and apparently healthy women, undiagnosed heart disease is still a common killer (3rd behind unintentional injuries and cancer in her age group), and her autopsy findings highlight the importance of screening women for underlying heart problems.

The most common causes of SCD are generally driven by age rather than sex. Athletes under age 35 both men and women alike are susceptible to genetically inherited structural heart problems including hypertrophic cardiomyopathy (HCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC), as well as potentially lethal heart rhythm problems called channelopathies. Above age 35, coronary artery disease predominates, with women being preferentially protected by their higher estrogen levels, until they reach menopause. Initially, the ten-fold higher incidence of SCD in men was thought to be simply due to the much larger numbers of men participating in endurance sports. But now that participation rates are becoming nearly equal, womens risk of SCD is still not as high as that experienced in the male population.

Several theories exist that might explain why women appear to be more protected from SCD during intense competition. One explanation may lie in the sympathetic nervous system, which is responsible for the bodys fight or flight response. Male physiology is observed to be wound more tightly, meaning that their arteries and blood vessels tend to constrict more during intense activity than women. The increased blood pressure adds resistance to blood the heart is pumping out. When this increased pressure load is coupled with an outpouring of adrenaline during competition, the strains placed on the heart may trigger lethal rhythm problems in susceptible individuals generally those with underlying inherited cardiac problems or acquired fibrosis (scarring) from long-term training. For unclear reasons, even in the context of equal training volumes, men more commonly develop potentially lethal fibrosis substrate, placing them at higher risk of SCD than women.

Another possible explanation relates to obvious hormonal differences between men and women. In some animal models, testosterone has been shown to affect the way the heart conducts impulses making men, at least in theory more susceptible than women to developing electrical instability resulting in malignant heart arrhythmias. Clinically, testosterone promotes thickening of the heart muscle, which may explain why men are more susceptible than women in developing complications from diseases like HCM and ARVC. Estrogens, on the other hand, are protective in this regard, and delay that same process of heart muscle thickening. Despite equal patterns of genetic transmission of HCM and ARVC between both sexes, hormonal differences may explain why these maladies tend to remain latent for a longer period of time in women, presumably translating to a survival advantage and lower risk of SCD.

Sports medicine screening programs are designed to identify potential cardiac risks in individuals who exhibit no outward symptoms of heart problems. Such programs aim to increase participation but to do so with a reasonable level of caution, to ensure the safety of the athlete. Despite the lower risk of SCD in women, screening is still important.

Pre-participation screening typically involves a comprehensive medical history review, focused physical examination, and in some cases an electrocardiogram (EKG). EKG tests are proven to be more sensitive than history and physical examination alone in detecting pathology, especially regarding heart rhythm issues. EKG interpretation should always be completed by a skilled reader able to distinguish the fine line between normal adaptation to exercise and pathology. Guidelines like the International Recommendations for EKG Interpretation in Athletes will increase reading accuracy and reduce the number of false findings, which often lead to expensive and unnecessary longitudinal testing. Men exhibit changes in their EKG patterns more often than women, and these variations in many instances are considered normal purely as the result of physiologic adaptation to training. On the other hand, women are less likely to stray from normal parameters, so most EKG changes are concerning and more likely represent a real problem.

Consistent endurance training induces physiologic remodeling, or normal adaptations to the heart resulting in improved efficiency of an athletes engine. Cyclists are unique because they typically perform the most prolonged exercise pattern more hours per day and more days per year than nearly any other athletes. Cyclists often sustain markedly elevated heart rates for extended periods of time during two distinct types of high cardiac output workouts. First, high intensity aerobic workouts at near peak efficiency, coupled with sustained elevations in heart rate, create a dynamic stress, or a volume load on the heart. And second, long tempo efforts punctuated by intense anaerobic dashes create static stress, exposing the heart to a pressure load because of sustained increases in blood pressure.

Cyclists therefore typically exhibit prominent changes in heart structure due to a combination of dynamic stress (volume overload) and static stress (pressure overload) resulting in generally increased cardiac mass, with mildly enlarged hearts and mildly increased heart wall thickness at least in men. Statistically, women are generally smaller than men with lower lean body mass. Due to their higher estrogen levels, women tend to adapt to exercise in a qualitatively similar manner, but quantitatively different than men showing only minimal heart enlargement and virtually no heart wall thickening. In fact, only about 7% of healthy women show any significant increase in their heart size due to habitual exercise, whereas 47% of men show cardiac enlargement.

Symptoms of heart problems in women are often different to those reported by men. For example, women are less likely to experience classic chest pain due to a heart problem, but may report more subtle symptoms like indigestion, heartburn, fatigue, or poor exercise performance. Misinterpretation of these sometimes confusing symptoms often leads to a delay in diagnosis and poorer long-term outcomes for women. An unexplained decline in athletic performance is obviously concerning to any elite athlete whether male or female because this may be the only clue to a serious underlying heart problem.

However, in young women, such nonspecific symptoms are often incorrectly blamed on things like menstrual problems, eating disorders, iron deficiency anemia, pregnancy, or thyroid disease. In many cases it is the womans primary care provider who must be savvy enough to exclude these other diagnoses, realizing there is a potential heart problem and then making an appropriate referral to a cardiologist.

Estrogen generally protects women from developing CAD at young ages, but the risk rises as they reach menopause. And paradoxically, some young women may actually be at increased risk for CAD because of a syndrome called Relative Energy Deficiency in Sports (RED-S). Sports which favor lean body mass are often associated with heavy training loads and dieting to achieve optimal body weight. In some women this results in the Female Athlete Triad of menstrual dysfunction, unexplained decline in performance (with or without an eating disorder), and decreased bone density, leading to increased probability of fractures.

Prolonged endurance training in young women can lead to menstrual irregularities resulting in the same kind of reduced estrogen levels typically seen in older postmenopausal women. These athletes should be evaluated for the more traditional cardiac risk factors such as high blood pressure, cholesterol problems, and diabetes, with appropriate intervention to modify their risk. Treatment of the Female Athlete Triad is challenging and may require a multidisciplinary approach to improve an athletes overall energy balance. Strategies include decreasing training volume, modifying dietary habits, medically replacing estrogen levels, promoting bone health with dietary supplements, and seeking appropriate professional help to correct eating disorders if present. Due to the focused and highly competitive nature of many endurance athletes, this is often a tall order to fill since they may resist decreasing their training volume.

Regular exercise is the cornerstone of prevention and treatment of many cardiac and non-cardiac diseases. But some researchers suggest that the benefits of exercise are like a drug the benefits of moderate training reach a plateau and exceeding that plateau, or overdosing, may be detrimental to the athletes health. Several studies have reported unexpected abnormalities in endurance athletes primarily in men suggesting either transient or permanent heart damage which puts them at risk for chronic heart issues. Findings have included a five-fold increased risk of atrial fibrillation (AFIB), increased coronary artery calcium deposits (which indicate clinically silent CAD), and scarring of the heart muscle. However, there are several general guidelines that all athletes should be aware of:

The biological adaptation to handle the stress of pregnancy may be a key reason for the apparently better female adaptation to endurance training. Recent research has highlighted that during pregnancy, the body functions at a basal metabolic rate of 2.2 times the normal burning up to 4000 calories a day. Extended over a period of 40 weeks, pregnancy can essentially be considered the ultimate endurance event a true test on the limits of human performance. Under typical circumstances, a body functioning above 2.5 times the normal metabolic rate over a prolonged period will begin to break down. But most women emerge from pregnancy and go on to live healthy lives, having tolerated a level of metabolic strain considered by some to be similar to that experienced by athletes participating in some of the most competitive endurance events.

There are also massive changes in the amount of fluid in a womans body during pregnancy, creating cardiac stresses similar to endurance training. In order to support the developing fetus, she must increase her blood volume by a massive 50%, and her cardiac output by 40-50% constituting the ultimate dynamic stress on the heart. The female body appears to require less adaptation by the heart muscle and chambers to accommodate these changes.

More overlap in research examining the similarities between the effects of endurance training in women and the cardiac demands placed on them during pregnancy may help to explain these gender-based differences in adaptation to exercise and related cardiac risk. Additional research specifically devoted to women is critical to a better understanding of how gender influences normal cardiac adaptation to exercise, as well as to more accurately identify pathologic conditions which sometimes seem to overlap with normal physiology.

Despite the substantially lower risk of SCD in women, cardiac risk screening of female endurance athletes and at-risk pregnant women is still important, and should be carried out by clinicians familiar with the differences in adaptive physiology between men and women. Women often experience challenging and atypical cardiac symptoms, requiring a high index of suspicion on the part of their doctors often at the primary care level to identify these underlying problems. As the current generation of elite female athletes matures into tomorrows Masters champions, we will undoubtedly learn a great deal more about the long-term cardiac implications of endurance training in women.

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The Outer Line: The impact of endurance training on the cardiac health of women - VeloNews

Meet the women who are turning to sperm donation to become solo mums – The Sun

AFTER a challenging 17-hour labour, Laura Holloway held her newborn daughter in her arms.

With her mum Kath, 60, by her side, she gazed at Violet and knew shed done the right thing by having a baby on her own.

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Id never been more sure of anything, says Laura, 32, from Derby. I had no room for a man in my life at that time.

"People say: Youre so brave. But I would have been braver if Id left having a baby to fate. I was getting the one thing I really wanted, rather than risking waiting longer.

Laura is not alone. A recent report from the Human Fertilisation and Embryology Authority (HFEA) revealed that more women than ever are seeking sperm donation to become a solo mum.

It reported a four per cent increase in single women undergoing IVF cycles between 2016 and 2017, and a six per cent rise in single women undergoing intrauterine insemination (IUI), in which sperm is inserted into the womb.

In October this year, actress and singer Natalie Imbruglia announced she had given birth to son Max Valentine after using a sperm donor.

Meanwhile, last April, former X Factor judge Cheryl told a newspaper she didnt think you needed to be in a relationship to have children. There are definitely other routes I would consider, she said.

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Theres been a big shift in womens roles: we have been encouraged to have jobs and take up opportunities that our mothers and grandmothers never had, says Caroline Spencer, fertility coach at the Lister Fertility Clinic.

But at the same time its also expected that we would have a relationship and for many women thats not happened. Some turn to egg freezing, while others opt to go it alone.

Of course, there are no guarantees. According to the HFEA, birth rates for IVF decline as women age, from 25 per cent for those under 35, to 16 per cent if aged 35-37 and 14 per cent for those aged 38-39, to eight per cent for those aged 40-42.

For IUI, the percentages are even lower 19 per cent for under 35s, 14 per cent for those aged 35-39 and 5 per cent for those aged 40-42.

Its expected that we would have a relationship and for many women thats not happened. Some turn to egg freezing, while others opt to go it alone.

The odds arent great, but women like Laura are ready to take the chance. Having a baby was always important to me, she explains.

Then in my late 20s I was told I might have endometriosis, so I needed to get on with it. However, the men I dated werent right. There wouldnt be any connection but Id push it, thinking I needed to give it another try.

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"I realised I was so desperate to have children, I was looking for a guy who could father a child, rather than looking for love. So I decided to do it myself.

The first person Laura spoke to was her mum, who went with her to appointments at Care Fertility in Nottingham.

Then, in January 2018, Laura paid the clinic 3,280 using money she had inherited following the death of her father Phil in 2005 which covered tests, consultations, sperm and the drugs needed.

It felt like the perfect thing to spend it on. Mum encouraged me to do it, says Laura. I thought shed say I needed to get married, but she was excited.

Because of her age, Laura was offered the less intrusive IUI. I met with a donor nurse at the clinic and she went through a series of questions relating to what I wanted in a sperm donor, such as hair colour, eye colour and height, she explains.

I thought it was ridiculous, because I wouldnt chose whether to date a man based on the colour of his eyes! The only criteria I had was that he was Caucasian, like me.

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Twelve days after insertion, a home test revealed Laura was pregnant and she was overjoyed.

Despite a difficult pregnancy during which she wrestled with nausea that meant she had to have time off work, she was certain she had done the right thing, and her daughter Violet was born on March 27, 2019.

I remember clinging on to Mum during the birth, Laura says. She had my sick all over her, but she understood. Shed done it herself, whereas a man wouldnt have known what I was going through.

From the minute I held Violet, Ive never looked back for a second. When I am ready to date again, Ill go into it so much more relaxed, because Ive got what I wanted I have my baby. So this time around, hopefully Ill meet someone for the right reasons.

Caroline explains its important that women thinking about solo parenthood carefully consider how much help theyll need, both during the pregnancy and after the baby is born.

From the minute I held Violet, Ive never looked back for a second. When I am ready to date again, Ill go into it so much more relaxed.

We encourage women to think about the support networks theyll need, to think very carefully about who would be the person you could phone to get more Calpol in the night or who will be there for you when you feel totally overwhelmed, she says.

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Camilla Pratt, 35, from Leeds, knows only too well how difficult it can be. A lecturer in primary education, Camilla eventually decided to embark on fertility treatment in January 2018.

I always knew I was going to be a solo mum. Relationships hadnt worked out for me, and I was never interested enough in anyone, she says.

So I went to a Donor Conception Network conference, researched on Google and went on to have IVF costing around 2,800 in January 2018. I conceived on my second try.

With extreme sickness and tiredness, Camilla struggled both physically and emotionally during her pregnancy.

Women need to think about how much help they'll need, both during the pregnancy and after the baby is born.

I couldnt do all the things I used to do, like play lacrosse, plus work was tough, she says. Friends helped as much as they could, but it was a horrible and extremely gruelling time. It was the same during the birth.

"Two friends were my birthing partners, but I felt so sick and dehydrated, and then Oscar got stuck in the birth canal. After 36 hours, I had an episiotomy and emergency forceps delivery. I was in hospital for five days.

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In the weeks after the birth in January 2019, Camillas family and friends rallied round when she didnt even have the strength to get out of bed. Her parents came to stay, followed by a friend, while another friend organised a night nanny.

That April she needed two further operations to help repair the damage shed suffered during labour, and after her surgery, her parents took her and Oscar to stay with them for three weeks.

I felt like Id never even make it to the supermarket again, like Id never have a whole night of sleep or leave the house, she remembers.

I was thinking: What have I done? I had a lovely life! I knew it would be challenging, but I didnt realise how much time I would need to recover physically, as well as deal with a baby in my arms.

After three and a half months I began to feel like I could be a mum, and to enjoy it without being in pain or so tired.

"Now, 11 months in, Im back at work full-time and making sure I get out in the evenings two or three times a week to do sport my friends babysit or I take my son with me to a mother and baby class, and Im feeling so much more positive.

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Camillas not currently dating, but she hasnt ruled it out in the future. She has also frozen some embryos should she decide to go it alone a second time.

It would be nice for Oscar to have a sibling, especially as hes donor-conceived it would give them a unique bond, she says.

As well as the practical difficulties, some solo mums also struggle emotionally particularly with letting go of the dream of having a baby with a man they love.

The vast majority of the women that Ive coached are nervous, says Mel Johnson, founder of The Stork And I, a support and coaching service for women considering solo motherhood.

There are three main things that cause anxiety: grieving the loss of having a baby in a relationship, whether theyll physically, practically and emotionally be able to cope, and managing loneliness. Its all about letting go of the fairy tale that you grew up with.

Susie*, a digital communications manager from Surrey, was particularly affected by this sense of grief.

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It did take me a while to accept that using a sperm donor was going to be both mine and my childs story, forever, says Susie, 45, whose daughter Katie* is now eight.

There were days when Id walk round the park crying, wondering what Id done. Theres a relentlessness to parenting on your own and the solo mums path is hard to travel.

Susie says she thinks theres no longer a huge stigma in admitting youve had solo IVF but admitting to regrets is a different matter.

I think there are plenty of solo mums who have regrets, myself included, but for many, admitting it is possibly more of a taboo than saying theyve had solo IVF, she says. Its not that I wish I hadnt done it at all, its more that I wish I hadnt had to.

I still feel sad Ill never know what its like to share the experience of having a child with someone.

"When I see my daughters friends with their dads, or think about my relationship with my own dad, I regret that she will never know that.

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Financially, its been a struggle, too. Being the sole breadwinner is probably the toughest thing about parenting on your own, knowing that its all on you financially, Susie says.

Juggling work with school pick-up hours was hard. In fact, Ive gone self-employed, rented out my house and moved in with my mum to make things work not just when it comes to money, but also with things like attending school events.

"Ive been lucky to rely on my mum, which I know not everyone can. I didnt want to go through the process of being a solo mum only to miss out on school plays.

Being the sole breadwinner is probably the toughest thing about parenting on your own, knowing that its all on you financially.

As for how she became pregnant, Susie has been open with her daughter and anyone else who has asked from the start.

At first, I felt awkward telling people, but now I dont care. With Katie, I would talk to her even when she was too young to really understand, explaining that I had her by myself with a special seed from the doctor.

"Katie took it in her stride, and Ive even heard her say to people at school that she simply doesnt have a daddy.

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According to Caroline, there are plenty of resources such as websites and books to help solo mums navigate telling their children, and most find their own way instinctively.

Another thing they have to consider, however, is the fact that their child may one day want to access their donors details.

We have whats called ID-release donation in this country, which means that at 18 a donor-conceived person can apply to the HFEA and ask: Am I donor conceived? If they are, they can ask for the donors name, date of birth and last known address, she explains.

The donor-conceived person can also learn of any siblings conceived using the same sperm. Susie says: If Katie wanted to find out who the donor was, I would fully support her when the time came.

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Now Susie is hopeful the hardest part is over. Despite sometimes regretting that she was forced to make the choices she did, she wouldnt change her daughter for the world.

It does get easier as your child grows and you can communicate with them, she says. You become a little team.

"Those moments when its just me and her, snuggled in bed or on the sofa, make it all worth it. Sometimes I just look at Katie and think with awe: I made you!

*Names have been changed

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Meet the women who are turning to sperm donation to become solo mums - The Sun

Postdoctoral Fellow in the Research Division for Molecular and Cell Biology job with THE UNIVERSITY OF HONG KONG | 188833 – Times Higher Education…

Work type: Full-timeDepartment: Research Division for Molecular and Cell Biology (25003)Categories: Academic-related Staff

Applications are invited for appointment as Post-doctoral Fellow in the Research Division for Molecular and Cell Biology (Ref.: 499200), to commence on March 1, 2020 for one year, with the possibility of renewal.

Applicants should possess a Ph.D. degree in genetics or developmental neurobiology, a strong background in using model organisms to study the genetic basis of neuronal differentiation and circuit formation, and a good publication record in relevant field. They should have excellent communication skills in written and spoken English, great trouble-shooting skills, effective collaboration skills and be able to conduct research independently. Those with research experience in the nematode C. elegans and skills in computational biology would have an advantage.

The appointee will carry out investigations in the field of developmental neurobiology using C. elegans as a model system and applying various genetics, genomics, and imaging techniques to study the mechanisms of neuronal differentiation and circuit assembly. He/She will participate in potential projects to study the mechanisms that regulate neurogenesis, cell fate decisions, and neuronal morphogenesis; and investigate the mechanisms that instruct the formation of electrical synapses in neural circuits. Background information about the research concerned can be found at http://www.zhenglabhku.org. Enquiries about the post should be sent to Dr. Zheng at cgzheng@hku.hk.

A highly competitive salary commensurate with qualifications and experience will be offered, in addition to annual leave and medical benefits. At current rates, salaries tax does not exceed 15% of gross income.

The University only accepts online application for the above post. Applicants should apply online and upload an up-to-date C.V., a brief statement of research interests, and the contact information of 2 referees. Review of applications will commence as soon as possible and continue until February 1, 2020, or until the post is filled, whichever is earlier.

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Postdoctoral Fellow in the Research Division for Molecular and Cell Biology job with THE UNIVERSITY OF HONG KONG | 188833 - Times Higher Education...

Charles River Announces Strategic Partnership with Bit Bio, Increasing Portfolio of Translational Drug Discovery Technologies – BioSpace

Dec. 10, 2019 13:00 UTC

WILMINGTON, Mass.--(BUSINESS WIRE)-- Charles River Laboratories International, Inc. (NYSE: CRL) today announced that it has entered into an exclusive Discovery and Safety Services partnership with Bit Bio, a company that offers consistent and efficient reprogramming of human cells for use in research, drug discovery, and cell therapies.

By applying an engineering approach to synthetic and stem cell biology, Bit Bio has developed proprietary technologies for the efficient, consistent, and scalable reprogramming of induced pluripotent stem cells.

Cellular Reprogramming

Cellular reprogramming is the process by which human stem cells, given a precise set of genetic instructions, differentiate into a desired cell type. Current cellular reprogramming approaches are inefficient, with low cell yields, creating a gap for applications requiring high quality, consistent, and pure human cells.

To overcome this hurdle, Bit Bio has developed a gene engineering approach, opti-ox (optimised inducible over-expression). This platform, validated on both muscle and brain cells, enables precise, controllable stem cell reprogramming. According to Bit Bio, the process is more efficient and scalable than available technologies in transforming stem cells into desired cell types.

By combining the purity, scale, and speed of the opti-ox platform with deep learning algorithms, Bit Bio has the potential to accelerate the discovery and application of every single human cell type.

Partnering for Translational Drug Development

By partnering with Bit Bio, Charles River plans to offer clients access to an expanding suite of authentic human cells through their use in target discovery, validation and screening services. In drug discovery and safety, the use of high quality, authentic human cells at scale will enable the development of therapies with a higher chance of success in patients. Additionally, through the partnership, Charles River will contribute to the development and validation of novel cell lines.

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About Charles River

Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. To learn more about our unique portfolio and breadth of services, visit http://www.criver.com.

View source version on businesswire.com: https://www.businesswire.com/news/home/20191210005520/en/

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Charles River Announces Strategic Partnership with Bit Bio, Increasing Portfolio of Translational Drug Discovery Technologies - BioSpace

Key Protein Linked to Aging Is Discovered – Technology Networks

Aging is a dramatic public health issue in the face of the current demographic changes: the proportion of 60 and over in the worlds population will almost double by 2050. In this context, a new discovery has just broadened scientific knowledge. Researchers from the Developmental and Stem Cell Biology Department at the Institut Pasteur shed light on the mechanisms of senescence, by identifying a key protein associated with aging.

Currently, most of older people die of noncommunicable diseases such as heart disease, cancer and diabetes, rather than infectious or parasitic diseases, even in developing countries. Thus, ageing is a major public health issue and the Institut Pasteur is committed to being a major player in research in this area.

A better understanding of the fundamental mechanisms that lead to ageing will pave the way towards ultimately healthier aging, which is a major socioeconomic issue for the coming decades.

Identification of a key protein linked to ageingSenescence, which is a process that limits proliferation of damaged cells in response to various types of stress, has been associated to aging. Accumulation of senescent cells in tissues may contribute to organ degeneration and age-related diseases. As a result, clearance of these cells has been associated with slower aging and longer healthspan in animal models.

Scientists from Institut Pasteur and CNRS demonstrated that progressive depletion of a protein drives proliferating cells into irreversible aging. Moreover, such a depletion is a very early trigger, and therefore a determinant of cellular aging, or senescence.

This factor, called CSB is involved in Cockayne syndrome, a disease affecting about one in every 200,000 people in European countries. The absence of CSB protein or its dysfunction causes early aging, photosensitivity, progressive neurological disorders and intellectual deficit in patients with Cockayne syndrome. We had previously shown that the absence or impairment of CSB is also responsible for dysfunction of mitochondria, the power plant of cells says Dr. Miria Ricchetti, head of the team Stability of Nuclear and Mitochondrial DNA within the Stem Cells and Development Unit at the Institut Pasteur. This new study reveals the very same alterations in replicative senescence, a process strictly linked to physiological aging says Ricchetti.

The importance of the present discovery is that it shows that a factor that was considered to be stable in normal cells is instead progressively depleted when they proliferate. When this happens, the cell is irreparably committed to the dead end of senescence.

The exhaustion of CSB is driven by epigenetic modifications (reversible and regulated modifications of gene expression, without altering the DNA) that block its expression at the DNA level. Moreover, a molecule previously identified by these researchers as being able to reverse the defects of Cockayne syndrome patient cells, is also able to attenuate the commitment of normal cells to senescence.

"These studies demonstrate an important link between the [pathological] accelerated aging process and normal aging, and also expose the CSB protein as a key factor against cellular aging" concludes Ricchetti.

Reference

Crochemore et al. (2019) CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence. Nature Communications. DOI: https://doi.org/10.1038/s41467-019-13314-y

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Fate Therapeutics Presents its First Off-the-shelf, iPSC-derived CAR T-Cell Cancer Immunotherapy Program at ASH Annual Meeting – Yahoo Finance

FT819 Exhibits Enhanced Tumor Clearance In Vivo Compared to Primary CAR T Cells in Preclinical Leukemia Model

Master Engineered iPSC Line for FT819 Fully Characterized for Complete Elimination of TCR Expression and Integration of Novel 1XX CAR into TRAC Locus with No Evidence of Off-target Effects

Company Plans to Submit an IND Application for FT819 during 1H20

SAN DIEGO, Dec. 10, 2019 (GLOBE NEWSWIRE) -- Fate Therapeutics, Inc. (FATE), a clinical-stage biopharmaceutical company dedicated to the development of programmed cellular immunotherapies for cancer and immune disorders, announced new in vivo preclinical data for FT819, its first off-the-shelf, iPSC-derived chimeric antigen receptor (CAR) T-cell product candidate, at the 61st American Society of Hematology (ASH) Meeting and Exposition in Orlando, Florida.

FT819 is derived from a clonal master engineered induced pluripotent stem cell (iPSC) line with complete elimination of T-cell receptor (TCR) expression and a novel 1XX CAR targeting CD19 inserted into the T-cell receptor alpha constant (TRAC) locus. The cell product candidate is being developed under a collaboration with Memorial Sloan Kettering Cancer Center (MSK) led by Michel Sadelain, M.D., Ph.D. The Company has now selected a single engineered iPSC clone, and generated and fully-characterized the master engineered iPSC bank for GMP production of FT819.

CAR T-cell therapy continues to deliver remarkable outcomes for patients with hematologic malignancies, and next-generation approaches are needed to enable broad and timely patient access and reduce the cost and complexity of therapy, said Scott Wolchko, President and Chief Executive Officer of Fate Therapeutics. With early evidence of clinical activity for our off-the-shelf, iPSC-derived NK cell programs, we are excited to lead in bringing next-generation CAR T-cell therapies to patients and plan to submit an IND for FT819 in the first half of 2020.

The Companys iPSC product platform unites stem cell biology and precision genetic engineering to create renewable master engineered iPSC lines that can be repeatedly used to mass produce cancer-fighting immune cells, replacing the high production costs, weeks of manufacturing time, and complex engineering processes required for current-generation CAR T-cell immunotherapies with an off-the-shelf product that has the potential to reach many more patients.

At ASH, scientists from the Company and MSK presented new in vivo preclinical data demonstrating that FT819 exhibits durable tumor control and extended survival. In a stringent xenograft model of disseminated lymphoblastic leukemia, FT819 demonstrated enhanced tumor clearance and control of leukemia as compared to primary CAR19 T cells. At Day 35 following administration, a bone marrow assessment showed that FT819 persisted and continued to demonstrate tumor clearance, whereas primary CAR T cells, while persisting, were not able to control tumor growth. Over the past twelve months, the collaboration team has worked to optimize its processes for making T cells from iPSCs, and has now shown the production of pure T-lymphocytes consisting of both CD8+ and CD4+ T cells having a global gene expression profile that is highly-similar to primary T cells based on a principal component analysis.

As proof-of-principle for the unique advantages arising from selecting a single engineered iPSC clone for the production of CAR T-cell therapy, the scientists assessed 747 clones after engineering a pool of cells using CRISPR. It was found that only about 2% of clones met the Companys standards for overall quality including containing both bi-allelic disruption of the TCR, proper insertion of the CAR into the TRAC locus without random transgene integrations, and no evidence of off-target genomic modifications or translocations. The Company selected the top-performing clone for generation of the master engineered iPSC bank for GMP production of FT819.

Fate Therapeutics has exclusively licensed from MSK foundational intellectual property covering the production and composition of iPSC-derived T cells. In August, the Company announced that the U.S. Patent and Trademark Office issued U.S. Patent No. 10,370,452 covering compositions and uses of effector T cells expressing a CAR, where such T cells are derived from a pluripotent stem cell, including an iPSC. The foundational patent, which expires in 2034, is owned by MSK and is licensed exclusively to Fate Therapeutics for all human therapeutic uses.

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About Fate Therapeutics iPSC Product PlatformThe Companys proprietary induced pluripotent stem cell (iPSC) product platform enables mass production of off-the-shelf, engineered, homogeneous cell products that can be administered with multiple doses to deliver more effective pharmacologic activity, including in combination with cycles of other cancer treatments. Human iPSCs possess the unique dual properties of unlimited self-renewal and differentiation potential into all cell types of the body. The Companys first-of-kind approach involves engineering human iPSCs in a one-time genetic modification event and selecting a single engineered iPSC for maintenance as a clonal master iPSC line. Analogous to master cell lines used to manufacture biopharmaceutical drug products such as monoclonal antibodies, clonal master iPSC lines are a renewable source for manufacturing cell therapy products which are well-defined and uniform in composition, can be mass produced at significant scale in a cost-effective manner, and can be delivered off-the-shelf for patient treatment. As a result, the Companys platform is uniquely capable of overcoming numerous limitations associated with the production of cell therapies using patient- or donor-sourced cells, which is logistically complex and expensive and is subject to batch-to-batch and cell-to-cell variability that can affect clinical safety and efficacy. Fate Therapeutics iPSC product platform is supported by an intellectual property portfolio of over 250 issued patents and 150 pending patent applications.

About Fate Therapeutics, Inc.Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of first-in-class cellular immunotherapies for cancer and immune disorders. The Company has established a leadership position in the clinical development and manufacture of universal, off-the-shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The Companys immuno-oncology product candidates include natural killer (NK) cell and T-cell cancer immunotherapies, which are designed to synergize with well-established cancer therapies, including immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens with chimeric antigen receptors (CARs). The Companys immuno-regulatory product candidates include ProTmune, a pharmacologically modulated, donor cell graft that is currently being evaluated in a Phase 2 clinical trial for the prevention of graft-versus-host disease, and a myeloid-derived suppressor cell immunotherapy for promoting immune tolerance in patients with immune disorders. Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit http://www.fatetherapeutics.com.

Forward-Looking StatementsThis release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 including statements regarding the safety and therapeutic potential of the Companys cell product candidates, including FT819, its ongoing and planned clinical studies, and the expected clinical development plans for FT819. These and any other forward-looking statements in this release are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, the risk that the Company may cease or delay planned development and clinical trials of any of its product candidates for a variety of reasons (including any delay in enrolling patients in current and planned clinical trials, requirements that may be imposed by regulatory authorities on the conduct of clinical trials or to support regulatory approval, difficulties in manufacturing or supplying the Companys product candidates for clinical testing, or the occurrence of any adverse events or other negative results that may be observed during development), the risk that results observed in preclinical studies of its product candidates, including FT819, may not be replicated in future clinical trials or studies, and the risk that its product candidates may not produce therapeutic benefits or may cause other unanticipated adverse effects. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the Companys actual results to differ from those contained in the forward-looking statements, see the risks and uncertainties detailed in the Companys periodic filings with the Securities and Exchange Commission, including but not limited to the Companys most recently filed periodic report, and from time to time in the Companys press releases and other investor communications.Fate Therapeutics is providing the information in this release as of this date and does not undertake any obligation to update any forward-looking statements contained in this release as a result of new information, future events or otherwise.

Contact:Christina TartagliaStern Investor Relations, Inc.212.362.1200christina@sternir.com

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Fate Therapeutics Presents its First Off-the-shelf, iPSC-derived CAR T-Cell Cancer Immunotherapy Program at ASH Annual Meeting - Yahoo Finance

‘Adulting’ is hard. UC Berkeley has a class for that – Los Angeles Times

Conner Wright is carrying a demanding course load in his final year as an English major at UC Berkeley: antebellum American literature, introduction to music therapy and a research seminar on William Shakespeare.

The 20-year-old senior is immersed in the works of Henry David Thoreau, Ralph Waldo Emerson, Herman Melville and Harriet Jacobs.

But Wright, who is anticipating his graduation in May, has the self-awareness to know he needed a little something extra to prepare for his launch into a post-college world, that a superior ability to interpret classic literary works may not be enough.

So he signed up for a class on adulting, where he is learning to create and stick to a personal budget, build a resume and apply for jobs and navigate romantic relationships in a time when online interactions are eclipsing face-to-face encounters.

I need to learn how to get this adult thing down and manage life, Wright said.

The class, which has 30 students enrolled in each section, is led by two Berkeley undergrads who plan discussion topics and schedule guest speakers to fill 90 minutes each week. The adults in training are among thousands of people across the country who have signed up for courses that focus on things such as cooking or budgeting or time management.

Jenny Zhou, left, and Belle Lau teach an adulting class at UC Berkeley.

(Josh Edelson / For The Times)

Adulting classes for college students and postgrads have swelled in popularity in recent years, in part because many high schools have largely abandoned life skills courses such as home economics, which were created to help students navigate the path to adulthood.

That trend, combined with armies of hovering parents who emphasize academic achievement to the exclusion of almost everything else, has resulted in university classrooms filled with students who scored a 5 on their AP Physics test, but struggle to plan for a weeks worth of groceries and meals.

In Portland, Maine, the Adulting School offers in-person classes on soft skills, such as interviewing, conflict resolution and making friends, along with topics such as personal finance and basic home maintenance.

Principal Rachel Flehinger said her students, who are typically in their 20s and 30s, have experienced their share of disdain over their so-called entitlement and laziness.

Weve had clients who are millennials having major anxiety that they didnt have these skills and didnt feel successful as an adult, she said. Theres a lot of self-loathing that happens.

Similar classes or in-person workshops have popped up at libraries and universities across the country, in private groups on social media and even on blogs tailored to college students. Some high schools have scheduled seminars on life skills as a way to prepare their students for life after graduation.

Sometimes students come up with their own solutions.

Neither Belle Lau of Washington nor Jenny Zhou of Arizona felt fully prepared for life away from home when they arrived at Berkeley two years ago. When Lau moved out of the dorms and into her own apartment during her sophomore year, her lack of self-reliance at the time became apparent. She was working, attending classes and, for the first time, had to plan her own meals, put money aside and cover her expenses. She quickly realized that she was spending too much money eating out all the time.

More than 200 students at UC Berkeley applied for two adulting courses offered this semester. More than half of them had to be turned away because of limited class size.

(Josh Edelson / For The Times)

Lau and Zhou noticed that many of their peers were having similar struggles.

Were thrown out into this world and have little idea about what the heck were supposed to do, said Lau, 21. I think in general we all feel a little bit lost and dont know where to start.

To remedy that, Lau and Zhou, 20, decided to create their own class.

When it was first offered last spring, every one of the 30 spots was filled. Seventy students had to be turned away.

Lau and Zhou added a second session this semester. More than 200 students filled out applications explaining why they wanted to take the 12-week course. The women accepted fewer than half who applied.

Column One

A showcase for compelling storytelling from the Los Angeles Times.

Adulting is one of dozens of student-run courses in the universitys DeCal (Democratic Education at Cal) program, in which students create and facilitate their own classes on topics that include those practical and fun and often arent addressed in traditional curriculum. The project is rooted in the ideals of Berkeleys free speech movement, launched in the 1960s when students pressed for and won greater academic rights.

Theres a class on criminal psychology, which aims to analyze the minds of criminals, particularly of those who commit heinous crimes, in an effort to understand factors that influenced their behaviors and led them to commit violent offenses. Students enrolled in Intro to Baking learn to make bread, cakes, pastries and other confections without setting you or your roommates on fire, according to the course catalog.

Another course takes participants on a journey to Hogwarts School of Witchcraft and Wizardry through discussions of Harry Potter novels.

The courses in DeCal count for one or two credits and are offered as pass/no pass; as a result, students say they are unlikely to add to their stress levels.

College is a time of so many transitions the losing of certain reference points and its relatively sudden, said Nancy Liu, an assistant clinical professor of psychology at UC Berkeley and the faculty sponsor for the adulting class this semester. Youre on your own for the first time, youre navigating a large system with limited support, youre taken out of past comforts and starting anew, you have new tasks that youve never had to deal with before.

Add to that the stress of a high-pressure academic environment, it makes sense that many would feel overwhelmed, she said.

College also sets the tone for much of what comes afterward: fostering those daily habits and routines; balancing work, school and life; remembering to file your taxes and keeping a budget; learning how to navigate interpersonal challenges with less scaffolding or support from experienced others. It seems crucial to address it head-on in a way that was valuable to students, Liu said.

Students learn basic life skills that experts say have been abandoned by traditional academia.

(Josh Edelson / For The Times)

When Lau and Zhou decided to create a class, they initially envisioned a course in cooking, a passion they share. That idea morphed into life hacks and, later, adulting.

When the two began brainstorming a syllabus, daily tasks such as laundry, sewing and car maintenance didnt make the cut. Instead, they focused on topics that are more abstract: time management, budgeting, fitness and nutrition, and relationships.

Each 90-minute session features a presentation from Zhou and Lau, juniors majoring in molecular and cell biology and integrative biology, respectively, and an outside expert who visits the class in person or via video chat. Last year, a recruiter from Lyft prepped students about job searches and a former accountant discussed filing taxes.

Those accepted into the classes, mostly seniors, have lamented that many of the things they were learning werent taught by their parents.

Laus mother, Allie Wu, says that parents dont trust their kids enough to do things on their own, adding that when theyre at home their parents pretty much take care of everything for them.

Wu says she has always been very independent, a trait that was a necessity when she arrived in the United States from Taiwan as a 22-year-old to pursue her MBA. Wu hoped her daughter would leave home with the same sense of self-sufficiency. But when Lau confessed to her mother that she struggled a bit her first year at Berkeley, Wu said she began to worry.

Those concerns dissipated when Lau told her about the adulting class she wanted to start with a friend.

Wu, who visited the class last year to talk about taxes, said the course is wonderful and unique.

I know shes in a good place now. Im very proud of her, Wu said. She knows what she wants and what she needs to accomplish her goals.

UC Berkeley students Belle Lau, left, and Jenny Zhou teach an adulting class for their peers.

(Josh Edelson / For The Times)

During the first week of adulting at Berkeley this semester, students were asked to come up with goals that were SMART specific, measurable, attainable, relevant and time-based.

To kick it off, Zhou asked whether anyone had ever set a goal they didnt accomplish.

A few hands shot up. Several people shifted uncomfortably in their chairs. A handful looked around the room.

In less than a minute, everyones hand was in the air.

After a brief lecture, Lau and Zhou split the class into groups of six, each assigned to discuss their goals for the semester. Precision was rewarded; vagueness had to be remedied.

Students shuffled their desks into haphazard circles in the classroom and made quick introductions. They bantered about the dread of 8 a.m. classes and late-night studying marathons that would compound that trepidation as the semester dragged on.

Then things got uncomfortable.

Some of the students spoke in hushed tones as they shared the goals they had written on sheets of paper in front of them and, along with those, their insecurities that they might not be doing this whole grown-up thing quite right.

Wright spoke up first. His goal was to build more healthful habits with diet and exercise before graduation. The group nodded in agreement.

Several students said better time management would make a huge difference in their lives. One woman, a junior, said planning and establishing a routine might keep her from staying up all night cramming for exams.

Another piped up, saying shed like to get more done during the day by limiting how much time she spends on her phone a common distraction.

Kate Curtis, a 21-year-old senior who showed up 10 minutes late to the class with a look of embarrassment and a quick apology, said shes long struggled with punctuality. Shes been late so many times to her job at a fast-food restaurant that her manager recently pulled her into a meeting to discuss it. She was humiliated and ashamed.

I want to learn to be dependable. I want other people to be able to count on me, she said.

Curtis, who transferred to Berkeley from a community college in Orange County, said she lived at home for the first two years of college and feels she was coddled longer than her peers.

Im eight hours away from home now, so Im actually on my own. I have to find my own doctor if Im sick. Ive just signed up for my first loan, and Im not really understanding what Im getting into, she said.

Lau acknowledged that she and Zhou dont have all the answers, but shes quick to note that parents shouldnt be faulted for their childrens lack of real-world knowledge.

Maybe it is our parents who arent teaching us these things we thought we should already know, but we dont want to blame our parents for us being naive or ignorant, she said. Its our responsibility as college students to know that if were struggling in some aspect, there are resources out there for us.

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'Adulting' is hard. UC Berkeley has a class for that - Los Angeles Times