Who is Alun Wyn Jones wife Anwen, when did the Wales Rugby ace marry her and how many kids does SPOTY n – The Scottish Sun

ALUN WYN JONES is looking to become the first rugby player to win the BBC Sports Personality of the Year award since Jonny Wilkinson in 2003.

The Welsh skipper is among the six nominees in the running for the accolade in Aberdeen on Sunday, with Raheem Sterling, Lewis Hamilton and Dina Asher-Smith also hoping to lift the coveted trophy.

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Jones helped Wales reach the semi-finals of the World Cup in Japan, while also becoming the country's most capped player - currently sitting on 134 - and winning the Six Nations Grand Slam.

And now looks to top off a magical year with the SPOTY award, where wife Anwen will be cheering him on.

Anwen Jones, nee Rees, is definitely going for most intelligent WAG, with rugby captain's wife a doctor of physiology.

After gaining her PhD in 2012, she became a lecturer of Physiology and Health at the Cardiff Metropolitan University.

Yet, she is not finished there, also helping the sport's side - having previously been a track athlete.

She was a Welsh 400m hurdles champion at Under-23 level while also competing at university and senior level - before packing her sporting career in to focus on studies.

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SCOTTISH RUGBY LEGEND Who is Doddie Weir, who did he play for and how many Scotland caps did he win?

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The couple married on June 29, 2014.

They live in the Cardiff area - despite Jones playing for Swansea-based Ospreys.

Alun Wyn and Anwen Jones share two daughters together, with Mali born in June 2015.

Efa came along three years later in April 2018.

The Welsh rugby skipper regularly shares moments with his kids on the pitch, while also posting photos of his time with the girls on Instagram in between fixtures.

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Who is Alun Wyn Jones wife Anwen, when did the Wales Rugby ace marry her and how many kids does SPOTY n - The Scottish Sun

Peter Snell Dead: 5 Fast Facts You Need to Know – Heavy.com

Peter Snell of New Zealand

Peter Snell, considered New Zealands greatest runner of all time, has died. He was 80 years old.

New Zealand Sports Hall of Fame confirmed the news, and reported that Snell passed away in his sleep while at his home in Dallas, Texas, where he lived with his Miki Snell.

As one of the famous Olympians in his home country, Snell was born in the Taranaki on December 17, 1938, and a graduate of Mount Albert Grammar School in Auckland. Training under Arthur Lydiard, Snell went on to win three gold medals: first in the 800 meters at the 1960 Summer Olympic games in Rome, and then in both the 800 meters and 1500 meters at the Tokyo Summer Olympics in 1964.

In 1962, Snell was made a Member of the Order of the British Empire. In 1965, Snell retired from competitive running, the same year he was made an Officer of the British Empire, and an autobiography of his life, No Bugles, No Drums, was published. In 1999, Snell was named Sportsman of the Century by the ALAC Sports Awards in Auckland. He is the only male since 1920 to have won the 800 meter and the 1500 meter at the same Olympics.

Heres what you need to know about Peter Snell.

After retiring form the sport, Snell moved stateside where he earned a degrees in sports physiology at University of California at Davis, and then his Ph.D. in exercise physiology at Washington State University.

He moved to Texas after being offered a job at the University of Texas Southwestern Medical Center. Snell was honored as an inaugural member of the American College of Sports Medicine in 1999, and recognized as an international scholar.

Remaining active into old age, Snell competed in Texas in table tennis. He finished in the Top 4 in the 75 & older category, and competed in the 2017 World Masters Game back in his home country, New Zealand.

In 2012, after collapsing during a game of racquetball, and being diagnosed with non-ischaemic cardiomyopathy and fitted with an internal defibrillator to protect him against further life-threatening episodes, Snell described table tennis as one of the few sports my weak heart will allow me to play.

Prior to table tennis, the perennial competitor became a big fan of orienteering, which is a group of sports that requires navigational skills. Participants use a map and compass to navigate from point to point in diverse and unfamiliar terrain, and Snell won his category for men 65 and older at the 2003 US Orienteering Championship. For a time, he served as the President of the North Texas Orienteering Association.

GettyPeter and Miki Snell

Not surprisingly, Snell met his wife through running. Miki, a champion masters athlete, had met Snells coach, Arthur Lydiard, numerous times throughout the running camps her womens track club sponsored in Dallas, and the legendary coach decided to invite Peter to Mikis clubs 13 km run and dinner at a Mexican restaurant, where two felt instant chemistry.

I was immediately attracted to her, and surreptitiously found out she was single and not in a steady relationship, Peter reminisced in an interview with Now to Love in 2017. A couple of weeks later, I took her to a Christmas dinner dance party and the rest is history. We had a lot of interests in common and whenever possible, I ran with her during workouts.

On the secret to their lasting marriage Snell said, We are fortunate to be on the same page in matters dealing with money, politics and religion. However, our common interest in sport and physical activity has been an important part of our lives.

Snell told Runners World of his parents George and Margaret Snell, I grew up in a sporting family. His mother played tennis, and his father golf.

The star athlete also had two siblings, brother Jack Snell, and sister Marie Berry Snell. With Wife Miki, he had two daughters Amanda and Jacqui Snell, along with two grand daughters, Sam and Jodi Snell.

Snell first developed heart problems in 2010, and a month ago, while on the way to a dentist appointment, he passed out while driving and crashed into numerous parked cars. He was not injured from the accident, and it was decided that an electrolyte imbalance caused him to pass out.

He had too low potassium and it just really played with him badly and caused anarrhythmia, Miki told Stuff, but that all signs were pointing to a full recovery.

Hes feeling better. Hes had another blood test and all his numbers are looking good Hes on a good path to feel a lot better and do better. Hes still a little panicked, because it was kind of a hard episode that he went through.

READ NEXT: Michelle Obama Defends Greta Thunberg Against Trumps Bullying

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Peter Snell Dead: 5 Fast Facts You Need to Know - Heavy.com

International Strawberry Symposium 2020, topics and speakers officially announced – International Supermarket News

International Strawberry Symposium 2020, topics andspeakers officially announced

(Rome, 11 December2019) The panel of speakersand the topics of the 9th edition of the International Strawberry Symposium,scheduled to take place in Rimini from 2 to 6 May 2020 and organized byUniversit Politecnica delle Marche and the Italian Council for agricultural researchand analysis of the agricultural economy (CREA), in association with theInternational Society for Horticulture Science (ISHS), have recently been finalized.

Over the course of thefive-days event, a total of 15 speakerswill discuss four topics: genetics, agronomy, certification/defence/physiology,and human health.

From a genetic perspective, Aaron Liston Professor of Botany and Plant Pathology at Oregon State University willretrace and revisit the origin of the octoploid strawberry. Steven J.Knapp Professor and Director of the strawberry cultivation program atthe University of California will speak about Traditional and Genome-InformedBreeding Strategies for Delivering the Next Generation of StrawberryCultivars. Qing-Hua Gao Senior Professor at the ShanghaiAcademy of Agricultural Sciences will focus on Interactions of strawberrywith fungus pathology and new germplasms enhanced with disease resistance. BatriceDenoyes Senior Researcher at the National Institute for AgriculturalResearch in Bordeaux will address the topic of Breeding for fruit anddaughter plants yield.

At the agronomic level, YiannisAmpatzidis Professor at the University of Floridas Department ofAgricultural and Biological Engineering, will introduce the topic ofAutomation, artificial intelligence, and robotics in strawberry production. AnitaSnsteby Research Professor at the Norwegian Institute of BioeconomyResearch will discuss Flowering and dormancy relations of strawberry andeffects of management and a changing climate for production. Peter Melis Researcher at Proefcentrum Hoogstraten in Belgium will consider how modern substratecultivation offers possibilities for a minimum of residues on strawberry. Zhang Yuntao Director of the Strawberry Program atBeijing Academy of Forestry and Pomology Sciences and China National GermplasmRepository of Strawberry in Beijing, and Chairman of Strawberry Section of ChineseSociety for Horticulture Science will report on the great impact ofthe 7th ISS on Strawberry Research and Industry in China.

The topics of plant certification, pest and diseasecontrol and post-harvest physiology will be discussed in an additional session of the Symposium. In particular, IoannisTzanetakis Professor of Plant Virology at the University of Arkansas will introduce the Strawberry plant certification in the 21st century: from grafting to bioinformatics and beyond. Juan Carlos DazRicci Senior Professor at the Argentine National Research Council(CONICET) and at the Universidad Nacional de Tucumn will discuss theIntroduction and suppression of the defence response mediated by fungalpathogenes in strawberry plants, while Sonia Osorio Algar Professor at the University of Malaga in charge of the fruit biotechnologylaboratory will focus on Network regulatory analysis of strawberry fruitspost-harvest physiology revealed by metabolomics profiling.

Finally, the effects of strawberries on humanhealth will also be part of a specific discussion by variousexperts. Stefano Predieri Head of the CNRs BioeconomyInstitute, Bologna Research Unit will speak about What can we learn fromconsumers perception of strawberry quality?. Francisco A.Toms-Barbern Professor at the Consejo Superior de InvestigacionesCientficas in Murcia will present the Role of ellagitannins in strawberryhuman health effects. Britt Burton-Freeman Chair of the Departmentof Food Science and Nutrition at the Illinois Institute of Technology willfocus on Strawberries and their polyphenolic metabolites in glucoregulationand vascular health. Daniele Del Rio Associate Professor ofHuman Nutrition at the University of Parma and Head of the University ofParmas Faculty of Advanced Food and Nutrition Studies will finally discussstrawberry polyphenols: metabolism in humans and putative biologicalactivities.

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International Strawberry Symposium 2020, topics and speakers officially announced - International Supermarket News

Through one soldiers eyes, World War IIs Battle of the Bulge – The Boston Globe

Suddenly we heard cannon fire, he wrote. Moments later shells were landing in the street outside our quarters. More shells and the windows were blown into our room. Grabbing our medical pouches, we headed down the stairway at the end of the hall.

Amid the confusion, my father was ordered in one direction and his two roommates were sent elsewhere. One of them Staff Sergeant John Winter, his best friend in the Army was killed, as was their company commander. They were among tens of thousands of Allied casualties during the last big Nazi offensive of World War II, which became known as the Battle of the Bulge.

Before that attack on Dec. 16, 1944, our own unit had been dormant for weeks, my father wrote. A degree of complacency existed amongst us.

In the days afterward, we were literally in panic. Convoys moved in all directions. Equipment and personal belongings were left behind. We moved from one town to the next, further and further backward ... back and forth. Sometimes returning again to the same town and a new location every few hours.

My father was a sergeant in the Army Medical Corps, and as he and others in his unit raced from town to town, somewhere we had a dead German soldier on our hands. Perhaps he died after we picked him up. I dont remember. We buried him in a shallow ditch in case we were captured and still had him in the ambulance.

For a day or two, he was assigned to a hospital in Huy, Belgium: My job, give injections of penicillin. So many casualties, by the time I finished one round, it was time to start again.

Those memories, rekindled decades later, found their way into the book he wrote a memoir that could easily have never existed.

Born in 1921, Donald S. Marquard was a prolific recorder of lifes events, large and small. He began writing diaries at age 9 and kept them on and off until several days before dying of a brain tumor, at 76.

He also was a lifelong dedicated letter writer, and while in the Army in basic training and Europe he sent hundreds home to family and friends.

In the mid-1970s, after his father had died and his mother was in a nursing home, he was cleaning out his boyhood home in a Connecticut town along Long Island Sound. In one box, he was surprised to find some 400 of his wartime letters that his mother had saved.

Taking them to our familys home in Vermont, he let a decade pass before opening the envelopes one day to find that some letters were beginning to fade.

To preserve the text, he copied them all out in longhand. In his memoirs prologue, he said he probably wouldnt have summoned the courage to start had he realized the task before me.

During those hand-cramping months, he found that re-reading what he wrote long ago revived long-forgotten memories he had never mentioned in letters that were subject to Army censors.

In his late 60s, having retired and joined a writers group, he began to fill in the gaps including his memoir passages about the early days of the Battle of the Bulge.

By contrast, he had been far more circumspect on Dec. 20, 1944, in his first letter home after the battle had begun.

Dear Ma, he wrote under his handwritten dateline Somewhere in Belgium, a purposefully vague location he listed in every letter, always in quotes.

Everything is going alright, he told his mother, and Im well but have been rather busy the last few days so that explains why I havent written.

Busy not getting killed, to be precise.

Offering reassurances was a common theme in the letters home after his unit left England the night of June 12, 1944, and headed across the English Channel during the invasion of Normandy.

In his first letter to his mother after landing on the Sugar Red section of Utah Beach early on June 13, he noted that he was now writing from Somewhere in France.

Am doing alright and feeling fine, he wrote. At last I feel that Im really helping out in my small way.

That last phrase, in my small way, provided the title for his memoir.

History books often celebrate the exploits of generals and heroes, but wars are largely won or lost by those whose days and nights are rarely recorded. My father wrote about the ordinary experiences of ordinary troops.

In the military, you wait in line a lot. He wrote about boredom, too.

Believe today is Sunday if Im not mistaken, he wrote home in late June 1944. Its rather easy to get mixed up on the dates and days now for one day is just like another.

Like soldiers throughout history, he traipsed through countries he had never expected to visit, complaining about rain and welcoming sunny days. The weather was a safe topic for letters reviewed by censors, but he summoned more pointed images in his memoir.

With much debris everywhere, it was sometimes difficult to drive through with a vehicle, he wrote of his time in France. Dead farm animals, bloated to enormous size by the heat and sun, lay in the fields and farm yards. Yet among all this, people survived and were attempting to put their lives back in order.

As he and other soldiers pushed on through Normandy, a German reconnaissance plane would fly over our area. Bed Check Charlie as we came to call him. Ack, Ack guns would cut loose as the dull thud of the shells bursting echoed high above us. One morning when I awoke, I found a piece of shell lying in my bedroll.

My father probably owes his survival in part to serving in the medical corps. Though not a doctor, he had trained to be a funeral director before the war, studying anatomy and physiology at a junior college. That was enough to earn a medical corps assignment.

He treated all manner of ailments. Some paratroopers who landed in Normandy before the ground troops were emotionally unable to adjust to the demands placed upon them, he wrote, adding that in later years they probably would have been diagnosed with PTSD.

My father also treated Nazi soldiers captured during the invasion. Using rudimentary German language skills, he struggled to communicate.

I still recall a German whom I endeavored to help, he wrote in his memoir. He kept pointing to his ear. I thought he had an injury and shaved a portion of his head. His only problem was that he couldnt understand me!

This year, the 75th anniversary of the action he saw in 1944, Ive been paging through his memoir and letters, reading about his wartime experiences on present times corresponding days.

He had inscribed for me a Xeroxed copy of his memoir as a Christmas present in 1993, less than four years before he died. I was in my 30s then and distracted in the way of children-turned-adults who are busy building careers.

Ill always regret not reading his memoir immediately and asking questions, even ones he might not have answered.

What had it been like for him to know that, at 23, he lived and his best friend died because they went separate ways leaving a stairwell? Did he feel some sense of duty the rest of his life to live up to the quirk of fate that gave him another half-century?

But in one sense, reading what my father wrote about World War II in letters as it unfolded and in memoir looking back when he was older is a way of having the conversation we never had when he was alive.

He speaks to me and others through his writing, excerpts of which I post occasionally on Facebook and Instagram with his wartime photos introducing his first-person accounts to an audience he surely sought by writing a memoir.

On the day the Battle of the Bulge began, my father was a sergeant, and Staff Sergeant Winter was his immediate superior. Since training stateside, they had spent nearly all their days together, including killing time with a 12-hour card game during a train ride through England, rowing on the River Thames while awaiting the Normandy invasion, and rooming together on Winters last night alive.

Yet whenever my father mentioned his friend, in person or on paper, he always called him Sergeant Winter, not John. Military respect never faded.

In the mid-1980s, I was a copy editor at Newsday, on Long Island, N.Y., where the headquarters was across the street from an enormous national cemetery. After the war, my father had visited that very cemetery to join his friends family for the burial, after Sergeant Winters remains were brought home from Europe.

The first time my parents visited me on Long Island, my father asked to visit the cemetery, where after some searching we found his friends grave.

His memoir was not yet written, and he had talked little about the war, so I had no sense of the enormity of the moment. My father was someone who laughed easily and cried never, but on that morning his voice broke as he and I stood by a grave he had last seen decades ago.

My friend Sergeant Winter, he said softly. I miss him.

Bryan Marquard can be reached at bryan.marquard@globe.com.

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Through one soldiers eyes, World War IIs Battle of the Bulge - The Boston Globe

Harvard Scientist Thinks It’s ‘Ludicrous’ to Compare His Genetics-Based Dating App to Eugenics – Daily Beast

A famed Harvard geneticist is defending his work on a genetics-based dating appand distancing himself from Jeffrey Epstein, the science-obsessed pedophile who fantasized about spreading his DNA by inseminating 20 women at a time at his ranch.

The fact that there are people with completely idiotic ideas about genetics doesnt mean Im one of them, George Church told The Daily Beast in a phone interview.

Just because they hung out with me briefly doesnt mean I bought into their malarkey in any sense, just like geneticists today dont buy into the eugenics of the 1920s.

Church has had to account for his links to Epstein numerous times since the disgraced money manager was indicted for sex-trafficking and then killed himself in jail last August. Most recently, he was grilled about their relationship during a 60 Minutes profile that included Churchs plans for the dating app, which critics have denounced as a modern form of eugenics.

Epstein helped fund Churchs lab at Harvard before being unmasked as a predatorbut Church has admitted maintaining contact with Epstein even after the financier served time and registered as a sex offender.

Now Church has confirmed to The Daily Beast that he was one of several notable scientistsincluding Harvard biology professor Martin Nowak, Harvard astronomy professor Dimitar Sasselov, MIT physics professor Seth Lloyd, and the pioneering biologist Steven Bennerwho attended a 2007 gathering on Epsteins private island Little St. James.

Photos verified by Church show them together on the beach and around a blackboard in discussion with Epstein. The property was nicknamed pedophile island by locals because of the alleged sexual abuse of girls, but Church said he saw nothing untoward at the gathering, which predated Epsteins 2008 guilty plea.

Scientific meetings take place all over the place, and usually youre so wrapped up in the meeting that you dont take advantage of the place youre in. This was one of those cases. We did our science nerd thing and left, he said, noting that the scientists slept on a different island.

Church said the attendees were there to discuss the origins of life and that Nowak later published a paper based on the discussions. We just came there for the meeting and then came back. We looked around the beach a bit. There wasnt much there, frankly. He was building something, some structure, he said.

Church said that Epstein had no influence on his work, which has been focused on allowing humans to live longer with fewer diseases.

To that end, he made an off-handed reference during the 60 Minutes interview to a dating app that would match couples with the goal of eliminating severe hereditary diseases. His brainchild was not well-received. A Fordham associate ethics professor told The Daily Beast the concept sounds like eugenics, likening it to the Nazi ideal of cultivating a master race.

Church said hes been describing the same idea for years now without any furor.

If you know what youre doing is the right thing to help families have healthy children, I dont think you need to worry whether somebody somewhere has been associated with you in a way thats less than ideal.

Church said it was preposterous to compare his work to eugenics.

Its ludicrous to think thats what Im doing, but it makes good clickbait, doesnt it? he said.

The app would prevent people from matching with partners with similar genetic mutations that would induce a congenital disease like Tay-Sachs on the couples children. The geneticist said the technology will likely work alongside established dating sites and apps as a premium service rather than as a standalone, and it wouldnt have access to a users full genome, only whether the person carries specific alleles related to congenital disease.

Eugenics is coercive. Rather than restricting peoples options for their health and their families, were expanding them, he said. Were not going to be forcibly sterilizing people, if thats the business model they think were up to. Thats as far from what we intend to do as can be.

The MIT Technology Review identified the technologys parent company as DigiD8, incorporated in September by Churchs cofounder Barghavi Govindarajan. Its slogan: Science is your wingman. Church said hes funding the app alongside private investors and declined to disclose the amount the fledgling company has raised, calling it adequate. Harvard is not among the investors, he said.

He sees the matchmaking app as a continuation of his work on genetics and part of his duty as a scientist.

I felt like Im providing all these great tools, but theyre very expensive. Gene therapy is a couple million bucks. I feel like its my responsibility to point out alternatives, he said. Its very early stage, though.

One of the questions lingering over the proposed technology is who will decide what genes the software will screen for. Would it further stigma against the chronically ill and disabled? Against trans people, as Vice suggested? Against certain races?

Church said he and his team would leave that question to clinical geneticists, but he described the criteria as genes that result in illnesses that cause very premature deaths, often with pain and a lot of medical costs. He said that the screening would likely rule out only five percent of someones dating pool.

There is no line, just as theres no line with what speed limits should be on the road, but you have to draw one, and medical doctors are very good at drawing practical lines, he said.

Church said hes open to critics, despite what he saw as their overreaction.

If any doubters, after they see whats actually there, make a compelling counterargument, I may change directions, he told The Daily Beast. Im very open to suggestions, and Im very interested to hear what everybody has to say once they see whats really there.

He said he wasnt expecting 60 Minutes to air his comments about the dating app. He published a FAQ Wednesday on his website explaining some details of what the technology would look like.

There are medical tests that perform the same function Churchs dating app would. Couples considering IVF can take genetic compatibility tests for specific conditions, and women undergoing the treatment can screen their embryos and weigh the option of abortion if they test positive. Churchs app would start far earlier in the romantic process, which he views as a positive.

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Harvard Scientist Thinks It's 'Ludicrous' to Compare His Genetics-Based Dating App to Eugenics - Daily Beast

Harvard Geneticist Making Genetics-Based Dating App Thinks It’s Ridiculous That We’re Comparing It to Eugenics – Jezebel

Photo: Craig Barritt (Getty Images for The New Yorker)

Harvard geneticist George Church thinks its ludicrous to compare his dating app that uses genes to pair adults together to eugenics. Its ludicrous to think thats what Im doing, but it makes good clickbait, doesnt it? Church told The Daily Beast.

Churchs dating app would stop people from matching with potential partners with similar genetic mutations that could result in conditions like Tay-Sachs, according to The Daily Beast. It would be a premium service on already existing dating apps. Eugenics is coercive. Rather than restricting peoples options for their health and their families, were expanding them. Were not going to be forcibly sterilizing people, if thats the business model they think were up to, Church said. Thats as far from what we intend to do as can be.

Hes painting the idea as a way to help people create families. If you know what youre doing is the right thing to help families have healthy children, I dont think you need to worry whether somebody somewhere has been associated with you in a way thats less than ideal, Church told The Daily Beast.

Curious about person associated with it whos less than ideal? Church used the interview to distance his connection to the late Jeffrey Epstein, who at one point proposed inseminating hundreds of women on his New Mexico farm. Just because they hung out with me briefly doesnt mean I bought into their malarkey in any sense, just like geneticists today dont buy into the eugenics of the 1920s, Church told The Daily Beast.

Epstein was one of the funders of Churchs lab at Harvard, and Church maintained contact with the convicted sex offender after Epstein registered as sex offender. In fact, Church went to Epsteins private island, Little St. James, in 2007. But dont worry, the scientists in attendanceslept on a separate island. Scientific meetings take place all over the place, and usually youre so wrapped up in the meeting that you dont take advantage of the place youre in. This was one of those cases. We did our science nerd thing and left, Church said.

Church said doctors will be the people drawing the line about what is acceptable to weed out of offspring, likely genes that produce illnesses that cause very premature deaths, often with pain and a lot of medical costs, he said. There is no line, just as theres no line with what speed limits should be on the road, but you have to draw one, and medical doctors are very good at drawing practical lines.

The only good part of this interview is his assertion that hes open to suggestions! If any doubters, after they see whats actually there, make a compelling counterargument, I may change directions, Church told The Daily Beast. Im very open to suggestions, and Im very interested to hear what everybody has to say once they see whats really there.

My compelling counterargument: Being casual about eugenics has never ended well.

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Harvard Geneticist Making Genetics-Based Dating App Thinks It's Ridiculous That We're Comparing It to Eugenics - Jezebel

This genetic variant is underdiagnosed, under-recognized, and deadly | Penn Today – Penn: Office of University Communications

A genetic variant in the gene transthyretin (TTR)which is found in about 3 percent of individuals of African ancestryis a more significant cause of heart failure than previously believed, according to a multi-institution study led by researchers atPenn Medicine. The study also revealed that a disease caused by this genetic variant, called hereditary transthyretin amyloid cardiomyopathy (hATTR-CM), is significantly under-recognized and underdiagnosed.

The findings, which were published inJAMA, are particularly important given the U.S. Food and Drug Administrations approvalof the first therapy (tafamidis) for ATTR-CM in May 2019. Prior to the new therapy, treatment was largely limited to supportive care for heart failure symptoms and, in rare cases, heart transplant.

Our findings suggest that hATTR-CM is a more common cause of heart failure than its perceived to be, and that physicians are not sufficiently considering the diagnosis in certain patients who present with heart failure, says the studys corresponding authorDaniel J. Rader, chair of the Department of Genetics at Penn Medicine. With the recent advances in treatment, its critical to identify patients at risk for the disease and, when appropriate, perform the necessary testing to produce an earlier diagnosis and make the effective therapy available.

Read more at Penn Medicine News.

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This genetic variant is underdiagnosed, under-recognized, and deadly | Penn Today - Penn: Office of University Communications

Harvard scientist develops DNA-based dating app to reduce genetic disease that critics call eugenics – The Boston Globe

His idea: to include serious genetic disease as part of the criteria on a dating app by asking users to submit their DNA for whole genome sequencing.

Sound weird?

Plenty thought so after Church, in an interview with CBSs 60 Minutes on Sunday, revealed that he is developing the genetic matchmaking tool that could be embedded in any existing dating app. The point of the DNA tool, he says, is to prevent two carriers of the same gene for a rare genetic disease from even meeting in the first place, by making sure they cant view each others dating profiles. That way, on the off chance two people meet on the app, fall in love, and have children, theyll know the baby wouldnt be at risk of having a hereditary disease.

Church calls it digiD8. And so far, it has freaked out a lot of people.

The word eugenics screamed across headlines this week. Vice called it a horrifying thing that shouldnt exist. Gizmodo said it was a dating app that only a eugenicist could love. And some advocates worried Church was trying to wipe out genetic diversity and people with disabilities altogether. Ever considered that having a disease doesnt mean a life thats tragic or full of suffering? Alice Wong, the founder of the Disability Visibility Project, wrote on Twitter.

So in an interview with The Washington Post this week, Church tried to clarify what hes planning to do and how a dating app encoded with your DNA would work. He stressed his strong opposition to eugenics while insisting his lab values genetic diversity, saying the app would only address a subset of the most severe genetic diseases, such as Tay-Sachs or cystic fibrosis.

There are a lot of diseases which are not so serious which may be beneficial to society inproviding, for example, brain diversity. We wouldnt want to lose that, Church said. But if [a baby] has some very serious genetic disease that causes a lot of pain and suffering, costs millions of dollars to treat and they still die young, thats what were trying to deal with.

Church is heading the dating app project with digiD8s cofounder and CEO, Barghavi Govindarajan, as a self-funded startup with some investors he declined to name, as the MIT Technology Review first reported after the CBS interview. Under Churchs bio on the startups website, theres just a quotation: That is not an outlandish idea.

Hes been known to make that case for a lot of his provocative ideas the timelines of which are not always clear. Church who apologized this year for accepting about $500,000 from multimillionaire sex offender Jeffrey Epstein between 2005 and 2007 has been saying throughout the past decade that a woolly mammoth could be brought back from extinction, or he could reverse the aging process in humans. Both of those projects are still underway at the lab, the latter of which is being tried on dogs, he and Harvard students told CBS.

By contrast, he said all the technology is already available for the dating-app tool. Now its just a matter of finding a matchmaking service that actually wants to do this.

Pushing back on the eugenics comparisons, Church said the foundation of his idea is in genetic counseling, which offers couples preconception or prenatal genetic testing to check whether their baby could be at risk of inheriting a disease.

Embedding that into an app would work like this, he said: First, you would submit a sample of your spit to a lab for whole genome sequencing. Church gave inconsistent numbers of genetic diseases that the test would screen for, at first saying 120 to 3,000 but then settling closer to 120. The results of the test would be encrypted and confidential, and not even you, the user, would get to know your results or the results of others, Church said. The rest would work just like normal online dating you just wouldnt see a small fraction of dating profiles.

About 5percent of children are born with a severe genetic disease, and so that means youre compatible with about 95percent of people, Church said. Were just adding this [tool] to all the other dating criteria.

Several bioethicists The Washington Post spoke with said they would hesitate to compare Churchs project to eugenics, which included state-sponsored forced sterilization, mass killings, or imposed breeding throughout the late 19th century to the 1970s. Eugenics is a strong word, said Barbara Koenig, director of the University of California at San Franciscos Bioethics Program.

Rather, both Koenig and Mildred Cho, a professor at Stanford Universitys Center for Biomedical Ethics, said digiD8 reminded them of the digital version of Dor Yeshorim, an Orthodox Jewish organization based in New York that beat Church to the idea by a few decades. Church has cited the group as an inspiration.

The nonprofit was founded in 1983 as a response to higher rates of Tay-Sachs a fatal genetic disorder that destroys the nervous system that was devastating certain communities, such as Ashkenazic and Sephardic Jews. Before marrying, couples can go to Dor Yeshorim for genetic testing. To avoid stigmatizing people, the organization does not tell couples anything about their genes, just whether they are compatible. This is especially important in societies where theres less reliance on termination [of a pregnancy], Koenig said.

In its earlier days, the group faced virtually all the same questions and uncertainties from critics that digiD8 is encountering now. Even a decade after Dor Yeshorim was founded, The New York Times asked in a 1993 headline: Nightmare or the Dream of a New Era in Genetics?

Cho said she could understand why people reacted so negatively to Churchs idea, fearing a slippery slope or unintended consequences to the genetic technology. For now its a dating app, but how else might others harness genetic technology in a way that could further invade lives? To Churchs critics, digid8 is already over that line.

I dont think those fears are completely unfounded, Cho said. I think what people are reacting to is this sense of kind of genetic determinism, and this idea that somebodys DNA can somehow make them incompatible, as if all their other personality traits and behavior really isnt as important as their DNA.

But for Koenig and Cho, the other big question, aside from whether this will work, is whether people would even care to use it. Do people even want this in their dating app? Thats a question Church said hes trying to figure out as well.

An app seems silly to me, Koenig said. People dont fall in love and marry and have children based on purely hyper-rational decisions.

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Harvard scientist develops DNA-based dating app to reduce genetic disease that critics call eugenics - The Boston Globe

Tipperary’s Dovea Genetics and Herdwatch join forces to launch new initiative – TipperaryLive.ie

Software company Herdwatch and AI company Dovea Genetics, two leading Irish companies in the Agri-sector, both headquartered in Tipperary with international operations, have entered a strategic partnership which will see the Herdwatch farm management software solution adopted by potentially thousands of Dovea Genetics customers.

Dovea Genetics was founded in 1952 and has been a leader in bovine artificial insemination (AI) since, while Herdwatch is part of FRS Network (Farm Relief Services), a farmer-owned co-operative established in 1980.

Herdwatch is used on over 11,000 farms in Ireland and the UK, making it the leading farm management software platform in those markets, while Dovea exports to 26 countries.

The two companies hope to bring even more efficiency gains to farmers who need every bit of help they can get in the current climate.

We are very pleased to team up with Herdwatch, as we share a common ethos and are both passionate about supporting our customers in making the best decisions for their farm business, said Dovea general manager Dr Ger Ryan.

He said that the Herdwatch solution had a full breeding life cycle module, integrated with ICBF, where farmers can track and manage serves, scans and get automatic reminders on due dates through-out their season which are all very important for our farmers.

Herdwatch has made a name for itself over the past six years by helping farmers save hours on paperwork every week, and make better decisions via an easy-to-use app on mobile, tablet or laptop.

The Roscrea-based software company is set to deliver even more innovation as it launches a completely new version of their software this week.

This new app, called Herdwatch NG (Next Generation) is leaner, meaner and faster than ever, according to the company.

FRS are very excited to be associated with the Herdwatch success story in Tipperary and right across the country, said Peter Byrne, FRS Network CEO and Herdwatch director.

This Next Generation app had taken significant investment and as a farmer-owned co-op FRS was delighted it will make such a difference for farmers, he said.

The new app is being launched at the Winter Fair in Belfast by rugby legend Rory Best, who uses Herdwatch on his suckler farm in County Down.

The Next Generation Herdwatch app will be a great benefit to me as I transition from professional rugby back to looking after our herd at home along with a few other projects. Like in Rugby, you have to make things which are complicated appear simple, and Herdwatch, which was already easy to use, will be faster and easier than ever before, said Rory.

The Herdwatch Next Generation app is available to download for free on the Apple App Store and Android Play Store. A free plan is available for all farmers, with yearly PRO memberships starting at 79, plus VAT.

For more information about Herdwatch, visit http://www.herdwatch.com or call 0505-34400.

For more information about Dovea Genetics, visit http://www.doveagenetics.ie or call 0504-21755.

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Tipperary's Dovea Genetics and Herdwatch join forces to launch new initiative - TipperaryLive.ie

Sanofi Says Its $2.5 Billion Biotech Takeover Is Just the Beginning – The Motley Fool

As the year comes to a close, Sanofi (NASDAQ:SNY) has a holiday gift for investors in the form of a new strategy. The French drugmaker announced a $2.5 billion biotech takeover in the growing immuno-oncology field earlier this week, then a day later said it is dropping research in the diabetes and cardiovascular fields. This is big news because Sanofi's top-selling drug is diabetes drug Lantus. The problem is that with pricing pressure from competitors, Lantus' sales have been sliding -- and fast.

IMAGE SOURCE: GETTY IMAGES.

Lantus brought in more than $1.2 billion in the third quarter of 2017, and by the same period last year, the figure dropped to less than $1 billion. Sanofi reported a 17.5% decline in Lantus sales to $837 million in the third quarter of this year. To make matters worse, the rest of the diabetes and cardiovascular business has followed, weighing down earnings, while areas including oncology and immunology grew.

That's why the stock market applauded new Chief Executive Officer Paul Hudson's plan to refocus the business. Sanofi shares gained 6.2% on Tuesday after Hudson's comments.

Hudson, in his quest to focus on products and areas that are growing, targets $11 billion in sales for eczema treatment Dupixent. Sales of the drug soared 142% in the third quarter to reach $635 million. The company also will prioritize the development of six innovative investigational products in the areas of hemophilia, lysosomal storage disorders, respiratory syncytial virus, breast cancer, and multiple sclerosis.

Halting research in diabetes and cardiovascular, along with other efforts, is meant to help Sanofi reach $2.2 billion in savings by 2022. In other financial news, the company plans on expanding its business operating income margin to 30% by that year and to 32% by 2025. Business operating income is a non-GAAP measure of financial performance in which Sanofi eliminates elements such as acquisition-related effects and adds items like share of profits or losses from certain investments. The company also aims to increase annual free cash flow 50% by 2022.

Sanofi is reorganizing its operations into three business units: specialty care, vaccines, and general medicine. Consumer healthcare, which includes products like over-the-counter painkillers, will be a stand-alone business with its own R&D and manufacturing processes. Reutersreported that Sanofi might sell the unit or look for a joint venture. Consumer healthcare generated $5.2 billion in sales for Sanofi in 2018, a 3% increase from the previous year. That was about half of the figure generated by the specialty care unit, which grew 29% year over year.

Sanofi said cash from its businesses will be spent on further investment internally, acquisitions, and -- good news here, investors -- increasing the annual dividend. The last payment, in May, was $3.42, increasing for the 25th straight year.

Considering all of the good news, Sanofi isn't looking expensive. According to Zacks research, it trades at 14.16 times earnings, slightly cheaper than the large-cap pharmaceutical industry average of 14.85. The stock has gained 17% so far this year to about $49, but Wall Street predicts at least a bit more upside, with the average analyst price target at $52. Investors should also bear in mind that analysts might adjust their estimates and outlooks in the wake of Hudson's presentation.

With total net sales down 1.1% in the third quarter and the former big businesses of diabetes and cardiovascular slowing, Sanofi didn't present the best investment case a few weeks ago. This week's news, however, changed the landscape. The company is acquiring immuno-oncology company Synthorx (NASDAQ:THOR) to boost a part of its own business that is growing. It is halting the spending on struggling units and reallocating resources to stronger ones. And it continues to think of investors with the goal of boosting dividends.

For those looking to add to pharmaceutical holdings, Sanofi looks like a promising candidate going into 2020 and beyond.

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Sanofi Says Its $2.5 Billion Biotech Takeover Is Just the Beginning - The Motley Fool