Anatomics proves viability of 3D printed surgical guides – 3D Printing Industry

Australian med-tech company Anatomics has conducted a study on the benefits of 3D printed patient-specific medical models for pre-surgical planning.

Using its 3D printed SpineBox kit to support spinal fusion surgery, Anatomics has measured the performance of the models on 129 patients, over a period of 27 months. These patients were all undergoing minimally invasive transforaminal lumbar interbody fusion (MIS TLIF) at a single centre, performed by the same surgeon. From the results, Anatomics has concluded that MIS TLIF represents a viable application for 3D printed patient-specific models, improving the efficiency and quality of the operation.

3D printed sternum implants

Based in Melbourne, Anatomics specializes in manufacturing and marketing surgical products to surgeons locally and internationally.

Working with Lab 22, the 3D printing service bureau arm of CSIRO (the Australian federal government agency for scientific research), Anatomics has 3D printed a number of medical implants over the years. In 2015 the company helped to design and 3D print a titanium sternum and rib implant for a 54-year-old patient in Spain, diagnosed with a chest wall sarcoma.Following this, again with Lab 22, it 3D printed a composite sternum and rib cage implant for a patient in the U.S. The implant was provided to a surgical team, led by Jeffrey L. Port of the New York-Presbyterian and Weill Cornell hospitals, who successfully performed the implant procedure on 20-year-old Penelope Heller.

Anatomics 3D printed sternum implant has also been implemented on a patient in the UK at Heartlands Hospital in Birmingham. The operation was the subject of a BBC TV series that aired in 2017 named Trust Me, Im a doctor, which went on to inspire further 3D printed titanium implant procedures.

How useful are 3D printed patient-specific models?

To carry out its study of surgical guides, Anatomics used patient imaging and surgical planning software to manufacture 3D printed patient-specific MIS TLIF kits for each of the 129 patients. These kits consisted of a 1:1 scale BioModel of the patients spine, stereotactic K-wire guide, osteotomy guide, and muscle retractors.

Each of the 3D printed spine models was used pre-operatively for surgical planning, patient consent, and education. Specifically, the BioModels can support procedures such as nerve decompression, fusion cage implantation, and help to provide accurate completion of the spinal construct.

To measure the efficiency of the 3D printed models on the patients, Anatomics considered the operating time, sterile tray usage, fluoroscopy screening time, operative waste and median hospital stay when using the BioModels. The accuracy of the planning provided by the 3D printed models was analyzed according to the number of screws and rods used if the interbody case measurements matched intraoperative data, and deviations in the implant size and screw placements.

After reviewing data gathered from postoperative CT scans, Anatomics concluded that its SpineBox kit presents a new benchmark for efficiency and quality in spinal fusion procedures. Notably, it found that the 3D printed models achieved a pedicle screw placement accuracy of 97.8 percent. However, there were some complications, including one intraoperative dural tear, and six reoperations. Not only are they helpful in treatment, but also in education for patients, as it allows the surgeon to explain in detail the nature of the surgery according to the specific individual.

Measuring the performance of patient-specific solutions for minimally invasive transforaminal lumbar interbody fusion surgery is published in the Journal of Clinical Neuroscience, ScienceDirect. It is co-authored by Ganesha K.Thayaparan, Mark G.Owbridge, Matthew Linden, Robert G.Thompson, Philip M.Lewis, and Paul S.DUrso.

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Featured image shows3D printed medical model. Photo via Journal of Clinical Neuroscience.

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Anatomics proves viability of 3D printed surgical guides - 3D Printing Industry

Berlin-based investor bets big on Humm, a wearable that can boost your memory and focus – Silicon Canals

Emerging technologies are contributing towards new developments in various branches of science, be it drug discovery or faster disease detection. The field of neuroscience is also reaping the benefits of modern technology as a graduate of the Berkeley SkyDeck accelerator program, Humm, has created a new device that claims to improve your working memory.

Take a look at winners of EIT Digital Challenge 2019.

Back in April, a study published in the scientific journal Nature Neuroscience found some fascinating results. Under the study, a mild electric stimulation was applied to 70 year old participants and their performance in certain memory tasks was noted to be on par with 20-year-olds. It was conducted by researchers from Boston University.

Drawing from over 30 years of research in the field of neuroscience research, Humm created a device that applies a mild electrical stimulation to help stimulate the brain and improve memory. The startup has now raised 2.3 million in seed round that was led by the Berlin-based investor Blueyard Capital.

With the latest round of funding, Humms total disclosed funding amount is 2.7 million. As mentioned above, it secured 2.3 million in its latest round of funding, which was led by the Berlin-based investor Blueyard Capital. CRCM Venture Capital and the Berkeley SkyDeck Fund participated with additional funding.

Humm will utilise latest funding to launch its first product, a wearable patch and a companion software app. The patch is called humm and it is clinically proven to help improve working memory by applying gentle stimulation to the brains attention and learning center. The device uses transcranial alternating current stimulation (tACS) to boost the power of theta waves produced in our brain that is touted to restore information flow and improve the ability to recall. The product is slated to hit the market in 2020.

Humm stimulates activity in the prefrontal cortex of your brain, which is linked to enable essential cognitive functions such as learning, decision making and problem solving. The company says that one will need to use the device for merely 15 minutes and they will get a mental boost for up to 90 minutes. Humm users can expect better recollection of learned material, better focus and multitasking, without the ill-effects arising from chemical stimulants like coffee.

Main image credits: Delivery Hero

Stay tuned toSilicon Canalsfor more European technology news

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Berlin-based investor bets big on Humm, a wearable that can boost your memory and focus - Silicon Canals

Neuroscience Market 2020: Global Industry Overview By Size, Share, Trends, Growth Factors, Historical Analysis, Opportunities and Industry Segments…

Zion Market Research analysts forecasts the latest report onGrowing Rate of CNS-Related Diseases has Significantly Boosted the Global Neuroscience Market, according to their latest report. The following report contains an interpretation of the marketing plan forNeuroscience Market. Global Neuroscience Market Report concentrates on the strong analysis of the present state of Neuroscience Market which will help the readers to develop innovative strategies that will act as a catalyst for the overall growth of their industry. (Sample Copy Here) This research report segments the Neuroscience Market according to Type, Application and regions. It highlights the information about the industries and market, technologies, and abilities over the trends and the developments of the industries.

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Neuroscience Market 2020: Global Industry Overview By Size, Share, Trends, Growth Factors, Historical Analysis, Opportunities and Industry Segments...

Humm raises $2.6M seed round for its wearable patch shown to stimulate your brain and improve working memory – TechStartups.com

Imagine a world where learning is effortless, where communication and control of technology are as simple as a thought and where every person has the power to expand their intelligence. In the last ten years, cutting edge neuroscience has opened new horizons for the improvement of the human brain.

At the forefront of this advancement is Humm, a neuroscience startup working to bring the incredible results of neuroscience research out of the lab and into non-invasive wearables that improve the quality of life for everyday people. Humm isthe maker of the first affordable, wearable patch for providing electrical stimulation to your brain,

Today, Humm announced it has closed a $2.6 million seed round, bringing total funding to $3.1 million.The Humm device has been clinically studied and shown to improve memory and learning. It is a disposable wearable patch, like a big bandaid and was tested in UCSF neuroscience clinical trials which showed that people can experience close to 20% faster learning speed after one 15-minute session. Humms product is used by the Air Force to help its pilots in training.

The round was led by Blueyard Capital with additional funding from CRCM Venture Capital and follow-on funding from the Berkeley SkyDeck Fund. Joining the companys board are Jason Whitmire, General Partner of Blueyard and Ariel Poler. Poler is a prominent Silicon Valley entrepreneur, investor and long-standing executive of the successful consumer health company Strava and UCSFs Health Hub.

Founded in 2017 byAhmud Auleear, Christopher Norman, Iain McIntyre, and Timothy Fiori, theBerkeley, California-based Humm is a recent graduate of the Berkeley SkyDeck accelerator. The startup is working with leading neuroscientists to bring its first patch to market; making neurostimulation technology 100-times cheaper and allowing users to experience the benefits in three minutes.

The new funding will be used to launch Humms first product, a wearable patch and software app that makes learning faster and easier by strengthening the neural circuits which regulate memory in the brain. The Humm patch is the first technology that has been shown to measurably improve working memory within just minutes of use, and for hours after. A persons working memory determines how many numbers, names and other facts they can hold in mind at any time, and improving it allows a user to do things like learn skills and information faster, focus better and multitask more effectively.

Ciarn OLeary, General Partner at Blueyard Capital stated, As software and biology continue to be on a collision course, new technology paradigms will emerge that will unleash creativity and empower scientists, clinicians and engineers to read, edit and write biology including key human functions. Humms technology improves the performance of the human mind and has the potential to expand healthspan for millions of people. So we are excited to be working with a team that is reinventing the form factor and experience of brain stimulation.

This is a very important time for Humm, said Iain McIntyre, Humm CEO and Co-founder. Using the patch is as easy as sticking on a BAND-AIDnothing bulky or awkward. In a 15-minute session, our clinical trial shows a 20 percent improvement in working memory capacity [against placebo] within the first three minutes of wearing a patch, that then lasts for more than an hour afterwards. In our testing with hundreds of early access users this year weve seen people doing exciting things with that boost, like accelerating the speed they can learn a language or remembering more of what they read.

Working with top neuroscientists in the field of neurostimulation at UC Berkeley and UCSF, Humm is continuing to refine the easy-to-use and inexpensive (less than $10) patch. The product is worn on the forehead, just above the prefrontal cortexa critical area of the brain for decision making and learning. It uses non-invasive electrical stimulation, which has been studied for the past 30 years and Humms particular method of choice, known as tACS, takes advantage of some of the latest exciting research in the area.

The companys early access store is now closed after receiving thousands of pre-orders from customers and a substantial order from the U.S. Airforce, but those wanting to be among the first to try may join a waitlist at http://www.thinkhumm.com. Humm plans to make the patch available to consumers in Q3 2020. The product will be demonstrated at the upcoming CES conference in Las Vegas January 2020. (Demo at the SkyDeck exhibit at the RAVV booth in Eureka Park #51263).

Our vision is to use this novel technology to replace medication and supplementation for the brain with a healthier, better alternative that nurtures and improves our mental capabilities,Added Mcintyre.

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Another year of climate change, genetics and Irish scientific ambition – The Irish Times

Here we are at the end of yet another year, a year that definitely went by faster than the year before or for that matter the year before that. And as ever at this time of year tis the season for casting ahead and divining what the future holds, delivering lists of top 10s and predictions of what will be hot and what will not.

In some fields, the resultant list will look very much like something delivered by the toss of a coin, but in the science and research areas it is pretty certain what will land in the top two or three subjects.

Number one has got to be climate and the impact of global warming. There is no other area that can match it for the variety and depth of research activity being applied to a whole range of climate-related subjects. And the hard news stories keep tumbling out of this endeavour, helping to show that global changes are taking place due to the alterations in climate that we as humans have set in motion.

One peer-reviewed study about the increasingly rapid loss of ice mass over Greenland was published less than a fortnight before Christmas. It showed that the biggest block of land ice in the northern hemisphere was melting away much faster than expected, seven times faster the study suggests.

Published in the journal Nature, it said the island lost 33 billion tonnes of ice on average during the last decade of the 20th century but the average annual ice loss for the most recent 10 years now stands at 254 billion tonnes of ice a year.

This is just one story and one research area, but climate-related studies arise in many fields from alteration of ocean currents to changed rainfall patterns and from species loss to poor air quality. It is also a subject area that affects us all given the potential of coastal flooding, crop losses and human migration to name but a few possible future impacts.

The impacts for humanity are also there in research into new ways to alter our genetic blueprints. The key to unlocking the potential to overcome gene-based diseases relates CRISPR CAS9, our current best technology for getting into the genome and then adding, deleting or altering individual genes.

It has the potential to reverse disease states by correcting unwanted mutations. It is being used in labs around the world as scientists seek to fully understand the method and apply it to alter genes. It is a powerful research tool, for example to create a mouse model that imitates a human disease state and then developing and testing drugs that might be used in humans. It also allows the researcher to look for any unwanted downstream effects arising from genetic alterations.

There are so many scientists using the CRISPR tools that news reports and discoveries will certainly follow. Yet most research scientists are concerned about the lack of controls or limits on what kind of genetic experiments that might be conducted on the human genome. Too little is known about unexpected problems if a number of genes are altered to eliminate a genetic disorder.

There is also the issue of genetic alteration of the germline, the genetic material that moves across to the next generation. There is currently an international block on germline alterations but that has not stopped at least one researcher who went ahead and created the worlds first two genetically modified humans. Breakthroughs will be delivered all through 2020 it is probably safe to say.

What might come third in this short list is up for grabs, and what might produce the next big scientific discovery could come from any direction. For that reason this report becomes a wish list relevant to Irish research and scientific endeavour related to our engagement with important international research bodies.

One of the most important decisions in this regard brings us closer to membership of Cern, Europes premier nuclear research body. A Dil committee studied the research and commercial potential arising from membership and called on the Government to join Cern as quickly as possible.

Cerns huge atom smasher confirmed the existence of the Higgs Boson, an international effort that involved many countries. Ireland could become more involved in this kind of research if it were a member. The Government has already taken the leap and announced our membership of the European Southern Observatory.

Our astronomers and physicists can now get access to some of the worlds largest telescopes based in Chile. The ESO is also a mill for discoveries and this membership gives us the potential to become international players in this field. And in more familiar territory, the Government has renewed its commitment to invest 100 million in the European Space Agency between now and 2024, a decision that ensures Ireland can bid for commercial contracts and researchers can participate in ESA activities. Our investment pays for itself given Irish companies can share in contracts.

All of the research areas mentioned here show how important it is to internationalise Irelands involvement in science. By doing this, we give more opportunities to promising young Irish scientists and help build a strong international reputation for research. Certainly that is not too much to ask for this Christmas.

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Another year of climate change, genetics and Irish scientific ambition - The Irish Times

Genetics plays a role in the effects of long-term methamphetamine use – News-Medical.net

New research led by La Trobe University in Australia has uncovered genetic clues which could explain why some people have more severe side effects from long-term methamphetamine use than others.

The research, published in Molecular Psychiatry found that variations in the gene known as BDNF strongly determine the effects of methamphetamine in the brain. This could potentially explain why some users develop methamphetamine-induced psychosis, which is similar to schizophrenia.

La Trobe neuroscientist Professor Maarten van den Buuse said the research, conducted using animal models, may lead to ways of identifying individuals at particular risk of developing psychosis and could mean a fundamental change in the way the effects of drug-induced psychosis on the brain are treated.

Drug-induced psychosis is generally treated with anti-psychotic medications, but these are not generally effective and are often associated with side effects. If further research is able to provide more details on the role genetics plays in the effects of long-term methamphetamine use, we could begin looking at therapies that would make a real difference for people affected by it."

Professor Maarten van den Buuse, La Trobe neuroscientist

The research looked specifically into the impact of methamphetamine use in adolescence and early adulthood, which is often when long-term users begin taking the drug, Professor van den Buuse said.

The findings are the result of collaboration between academics at La Trobe's School of Psychology and Public Health, and the La Trobe Institute of Molecular Science.

Source:

Journal reference:

Greening, D.W., et al. (2019) Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome. Molecular Psychiatry. doi.org/10.1038/s41380-019-0617-8.

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Genetics plays a role in the effects of long-term methamphetamine use - News-Medical.net

How Famous Psychologists Have Impacted Our Mental Health Over Time – The Good Men Project

Psychology is a vast field that studies human behavior. There have been many psychologists over the years that have made an impact on the field of mental health. One of the most famous psychologists that we hear about is Sigmund Freud. Freud believed that not all mental illnesses have causes that are due to the body; that mental health issues and problems can stem from our hurdles as children and the trauma weve experienced in life. Freud was one of the founders of psychoanalysis, and he believed in analyzing familial relationships in order to understand ourselves better. However, Freud is not the only famous psychologist that has made an impact on the mental health practices that we see in the world today.

Carl Rogers, who formed person-centered or humanistic therapy, had a huge influence on psychology. He believed that the client could lead a therapy session because he wanted clients to be able to solve their own problems. Rather than being seen as an authority figure, clients could see a therapist as a guide. Humanistic or person-centered therapy focused on the client rather than the therapist being an all-knowing being.

Erik Erikson was a psychologist that talked about human development, and he took Freuds work and expanded upon it. He focused a lot on childhood and adolescence and how those years impacted people later in life.

Jean Piaget focused on intellectual development in children and was integral in cognitive psychology. His focus was specifically on the bridge between childhood development as it went into adolescence. He also focused on epistemology and had a huge influence on cognitive psychology.

Ivan Pavlov, a Russian physiologist, did experiments that helped us understand human behavior. You may have heard of the term Pavlovian, and this is the person in history who inspired that term. One of Pavlovs famous experiments included a bell and a dog. After the dog heard a bell and got fed along with the noise consistently, the dog began to associate the bell with being fed. From this experiment, we learned about how our brains make associations and how we can use those associations to influence our behavior.

Carl Jung was a Swiss psychiatrist. He was one of the founders of analytical psychology. Jung focused a lot on dreams and the significance of our dreams. He believed in archetypal or archetypical images, so he believed that there were things in our minds that related to mythology or different fairy tales that would influence us. He also believed in the collective unconscious, meaning that there are things that we all experience over different cultures that contribute to our personalities. Jung talked about individuality and the self vs. our parents and family. Jung was very spiritual. He believed in finding the faith that made sense for you.

Elliot Aronsons work focused on motivational systems and finding out what the motivation behind different human behaviors was. Elliot was an American psychologist who is known for his experiments surrounding cognitive dissonance.

To understand human behavior, we need to do research, and one of the things that famous psychologists have done is to assess different human behaviors that help us understand why we do the things that we do. The reason that we have productive therapy methods today is that these famous psychologists laid the groundwork for treatment. If youre interested in learning more about yourself, consider seeing a therapist online or in your local area.

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How Famous Psychologists Have Impacted Our Mental Health Over Time - The Good Men Project

What Will AI Look Like In 10 Years? – SemiEngineering

Not all AI systems will behave the same, and that could be a big problem.

Theres no such thing as reverse in AI systems. Once they are let loose, they do what they were programmed to do optimize results within a given set of parameters.

But today there is no consistency for those parameters. There are no standards by which to measure how AI deviates over time. And there is an expectation, at least today, that AI systems will adapt to whatever patterns they discover in order to optimize power, performance and whatever other metrics are deemed important.

This is where the potential problems begin, because most of these algorithms are so new that no one really knows how they will age over time, or how they will be affected by the aging hardware on which they run. There are no rules or standard ways to define behavior, and there has been very little research (if any) on how systems that are not safety-critical will behave throughout their lifetime. In fact, its not even clear if research could be effectively conducted these days because the software and hardware are in an almost constant state of evolution. Its like trying to measure the impact of screen time on users with the introduction of the first smartphone.

There seems to be little concern about this across the tech industry. This is exciting new technology, and the amount of compute power that will be available to solve problems in the future probably will dwarf everything that has been achieved so far, at least in percentage terms. There are estimates across the industry ranging from thousands to a million times the performance of todays systems, particularly when the hardware is optimized for the software, and vice versa. Thats a lot of compute power, and thats only a part of the overall picture. Machines will talk to machines, and they will train other machines, and at this point no one is certain what to fix or how to fix it if something goes wrong.

This is always a challenge with new technology, but in the past there was always a human in the loop. In fact, one of the reasons we hear more about AI as a tool, rather than as an autonomous technology, is because some people in key roles are worried about the liability implications of unleashing technology on the world before they know how it will actually behave. Having a human in the loop greatly reduces that liability, particularly if you read through all of the end user license agreements. Machines talking to machines dont have the power of attorney (or at least not yet).

There is a lot to be said for AIs potential, both positive and negative. It is a technology that will be with us for a very long time. It will create jobs and take jobs, and it will restructure economies and human behavior in unexpected ways. On the design side, we will need to learn to utilize the best parts and minimize the worst parts. But it would greatly help if we understood better how to predict its behavior and what caused it to behave in ways that it was not trained to do. When that happens, we also need to know what other systems it communicated with and what the potential impact was on those systems.

Finally, for anyone designing these systems, wed greatly appreciate the addition of an easy-to-find kill switch in case something goes really wrong. Failing gracefully is a nice idea, but not everything goes as planned.

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What Will AI Look Like In 10 Years? - SemiEngineering

The New Yorkers Favorite Nonfiction Books of 2019 – The New Yorker

The Age of Surveillance Capitalism: The Fight for a Human Future at the New Frontier of Power, by Shoshana Zuboff

Shoshana Zuboffs disturbing, galvanizing The Age of Surveillance Capitalism deserves every comparison that its received to Rachel Carsons Silent Springanother masterwork that laid out, with unforgettable clarity, the degradation of ordinary life held captive to profit-seeking interests. Zuboff coined the term surveillance capitalism, half a decade ago, to describe the unique logic of accumulationrecently pioneered by Google and Facebook and now practiced by every app that secretly scrapes your phone for loose datain which surveillance is a foundational mechanism in the transformation of investment into profit. Surveillance capitalism, Zuboff argues, has insinuated itself through colonialist logic; tech companies wave flags of social improvement while plundering the land of human identity and experience to extract as much valuefor themselvesas they possibly can. We get some rewards from this process, of course, and we are constantly being reminded of them: the Internet connects us, the Internet gives us access to information, the Internet makes life convenient. And so, as the Internet becomes essential to social and economic participation, we are forced to accept the specific, monstrous asymmetry that it allows for, in which all accessible human behavior is converted into data and harvested in a process that was designed to be invisible to us, its value accruing only among a small group of technology capitalists. Under surveillance capitalism, we are alienated not just through the way we are forced to express our labor but through the way we are asked to express our lives. These new architectures, Zuboff writes, feed on our fellow feeling to exploit and ultimately to suffocate the individually sensed inwardness that is the wellspring of personal autonomy and moral judgement. But The Age of Surveillance Capitalism reminds us that the Internets central profit model isnt inevitable, any more than it was inevitable that we allowed our country to be permanently blanketed by pesticides. Surveillance capitalism can be curbed through sustained outrage and regulation, and itll have to be, or else. Jia Tolentino

The Uninhabitable Earth: Life After Warming, by David Wallace-Wells

You may remember David Wallace-Wellss article The Uninhabitable Earth, which was published in New York magazine in 2017a piece so widely shared and hotly debated that it required its own Wikipedia article. The story rendered the abstract threat of climate change in concrete, even cinematic, terms, informing the reader without surrendering an ounce of high-level drama. The Uninhabitable Earth: Life After Warming is Wallace-Wellss book-length expansion of the piece, and its just as potent, if infinitely more depressing. At its worst, it could be described as apocalypse porn. At its best, its perhaps the richest inventory of climate-change research yet published. Wallace-Wells makes clear, through a stream of startling factoids, that individual consumption choices can never make the difference that policy changes can. (Our smug organic-produce shopping, in others words, is virtually meaningless.) And yet the tidbit that struck me most was a fairly mundane one. Wallace-Wells writes that higher pollution levels have been strongly linked to premature births and low birth weightsand that the simple introduction of E-ZPass in American cities reduced both problems, in the vicinity of toll plazas, by 10.8 percent and 11.8 percent, respectively, just by cutting down on the exhaust expelled when cars slowed to pay the toll. Though a grim testament to the danger of carbon emissions, the fact that something as simple as E-ZPass could help is also encouraging. There may not be a silver bullet for climate change, but, as Wallace-Wells argues, theres still far too much potential for change for hope to be lost. Carrie Battan

Inside Out: A Memoir, by Demi Moore

The celebrity memoir is very often a noisy thing: from shocking tales of hardscrabble childhoods to juicy, behind-the-scenes dirt on the rich and famous, its not a genre that is known for its subtlety. And, on the face of it, Demi Moores recent autobiography (which she wrote in collaboration with my colleague Ariel Levy, a New Yorker staff writer) could serve as a prime example of the categorys melodramatic contours. Growing up in an emotionally and economically unstable home, the daughter of two charming but shifty narcissists, who were more often than not on the runfrom debt, from the law, from the very notion of parental responsibilityMoore, by sheer force of will, fought her way to become, for a time, Hollywoods highest-paid actress. She also raised three daughters and entered into and then left two high-profile marriageswith the action star Bruce Willis and, later, with the famously younger TV heartthrob Ashton Kutcherall while battling addiction, health and body-image issues, and a persistent sense of self-doubt that left her, as she writes, afraid to be in myself, convinced I didnt deserve the good and frantically trying to fix the bad. I love a good lurid celebrity autobiography as much asand maybe even more thanthe next guy, but as I read Moores I was surprised that what I liked about it wasnt, in fact, its gossipy revelations but the window it provided into the sensitive, reflective interiority of a woman who, for all her worldly success, has always been searching for the self-acceptance that eludes so many of us, whether were famous or not. By the end of the memoir, in a final section titled Surrender, Moore writes, of this quest, The truth is, the only way out is in. It is a tribute to the psychological acuity of this book that I felt the earned honesty of these words deeply. Naomi Fry

How I Became One of the Invisible, by David Rattray

The fearless poet, translator, and scholar David Rattray died shortly after the original publication of How I Became One of the Invisible, in 1992. He was fifty-seven, but he seemed to have lived many lifetimes, taking in as much of the world as he could. Trained at Harvard and the Sorbonne, he had an astonishing gift for language, mastering most of the Western ones and also Sanskrit, Latin, and Greek. He became famous at a relatively young age when, as a poetry-obsessed undergrad at Dartmouth, in the fifties, he went to visit Ezra Pound, who was then at St. Elizabeths Hospital, in Washington, D.C. He published an account of the visit, in The Nation, in which he managed to humanize Pound without letting him off the hook for his hatefulness. (One of Pounds former confidants, H.D., said that reading Rattrays article was the first time in more than a decade that she had laughed with affection about the confined poet.) This, in essence, was Rattrays great skill: to extend his zealous, compassionate intellect toward anyone, even those who may not have deserved it. This sensibility drove his work as a translator, bringing the works of Artaud or Hlderin to American readers as an act of empathy. How I Became One of the Invisible, which was reissued this year, by Semiotext(e), is the best kind of autobiographical writing, true to the eccentric digressions and mystical interludes of a life propelled by curiosity. Rattrays own spirit shines through his incredible stories about all the fringe-dwellers he befriended along the waythieves, radicals, artists. Van, his marvelous account of his friendship with the poet Alden Van Buskirk, opens with their first encounter: Rattray shaking Van Buskirk awake from a drunken slumber so that they could talk about poetry. Hua Hsu

How to Do Nothing: Resisting the Attention Economy, by Jenny Odell

Nearly everyone I know whos read Jenny Odells How to Do Nothing had told me that it inspired something akin to a personal crisis. The book, Odells first, is equal parts philosophical self-help and environmentalist tract, and it offers a fresh mode for thinking about life under technocapitalismand also some suggestions for what might be done. Odell is particularly interested in questioning the assumptions and incentives of the digital economy. The perversions that spring from productivity culture (to say nothing of attention as a currency and a resource) are corrosive not only on the individual level, she argues, but on a larger, social scale. She draws comparisons between the Internet and the natural world, making a case for the long-term maintenance of self, community, and place, both online and off. (I see little difference between habitat restoration in the traditional sense and restoring habitats for human thoughts, she writes.) Self-care, in this model, is not commodified self-indulgence; its a form of preservation enacted by reclaiming and reallocating ones attention. Odell is an artist, and her medium, often, is contexthistoricization, depth, analysis. This seems fitting. In a year in which the boundaries of cruelty and indifference stretched and expanded, there was also, among a certain set, a quieting or refocussing. In my own circles, some people disappeared periodically from Twitter and Facebook. A few grew more knowledgeable about plants and birds, or listened, with great conscientiousness, to non-algorithmic public radio. Most importantly, they began to ground themselves locally and socially and to reconsider where they placed value. The personal crises, it seems, had been productive. Anna Wiener

Go Ahead in the Rain: Notes to A Tribe Called Quest, by Hanif Abdurraqib

Go Ahead in the Rain is ostensibly a book about A Tribe Called Questa hip-hop group that formed in Queens, in the mid-eighties, and recorded six extraordinary albums before Phife Dawg, one of its founding members, died, in 2016but its ultimately more concerned with the furtive and inscrutable ways that music can rearrange a persons insides. Hanif Abdurraqib is a dexterous and elegant critic, but he understands that the spiritual exchange between artist and fan is sometimes too mysterious to be parsed objectively. So he takes a different approach: between passages detailing Tribes musical evolution and its significance to black Americans coming of age in the nineteen-nineties, Go Ahead in the Rain contains a series of letters from Abdurraqib to members of the band, in which he unpacks his devotion. I, too, have an interest in that which can be felt more than heard, he writes to Q-Tip, one of the bands M.C.s. Abdurraqib is a poet, and he writes with a precise, gorgeous rhythm that makes a reader want to linger on each line. (My copy of the book is dog-eared and highlighted into oblivion.) But what kills me the most is Abdurraqibs empathyfor the people who make the music that sustains us, and also for us, for being sustained. Amanda Petrusich

A Woman Like Her: The Short Life of Qandeel Baloch, by Sanam Maher

Sanam Mahers latest book, which is already out in South Asia and the U.K., and which is being released in the U.S. by Melville House in February, is a remarkable account of the life and death of Qandeel Baloch, a Pakistani entertainer who became famous through her bold social-media presence. She was then murdered by her brother, in 2016, for bringing dishonor to the family. Powerfully written and narratively creative, A Woman Like Her is less a conventional biography than it is an examination of modern-day Pakistan. By tracing Balochs brief lifeshe was only twenty-six at the time of her deathMaher, a Karachi-based journalist, provides illuminating glimpses into Pakistans entertainment, modelling, and news industries, and deftly charts the combination of attraction and repulsion with which Balochs fascinating online persona was greeted by Pakistani society. Isaac Chotiner

Municipal Dreams: The Rise and Fall of Council Housing, by John Boughton

I moved to London a little more than a year ago, and one of the books that has best helped me understand my new home is Municipal Dreams, a history of council housing in Britain, by the historian John Boughton. (Though published in 2018, the book was reissued in paperback form this year.) Boughton, who is also the creator of a long-running blog of the same name, provides a deeply informed account of the ways in which local and national governments in the U.K. have or have not sought to provide affordable housing for their citizens. His narrative begins by outlining the political and social idealism that underlay the very first council estate in Britain, the Boundary Estate, a well-planned village of Arts and Craftsstyle tenements built upon cleared slums in Shoreditch, in Londons East End, in 1900. It ends with the tragedy of Grenfell Tower, a high-rise in West London in which seventy-two people lost their lives, in 2017, when the buildings cladding went up in flames. On the way, Boughton narrates the glory years of council-housing construction, in the nineteen-sixties and seventies, when as much as a third of Britains population rented their homes from their local authorities, and when some of the countrys most thoughtful architects experimented with new styles of living. He also charts the right-to-buy schemes instituted in the nineteen-eightieswhereby residents could go from renters to owners, with mixed results for the urban fabricand takes note of the diminishing commitment in recent decades to building affordable homes. Boughton makes a strong case that public housinglike Britains public health serviceis a valuable good that merits greater investment, both financial and imaginative. He writes, The form and nature of public housing has been unfairly blamed for problems entrenched in our unequal society and exacerbated by the politics which reflect itan observation as true in the United States as it is in the United Kingdom. Rebecca Mead

Still Here: The Madcap, Nervy, Singular Life of Elaine Stritch, by Alexandra Jacobs

In 1964, the actress Elaine Stritchs blazing path through the New York theatre scene hit a rough patch: she was drinking too much champagne; she was lonely; she wasnt booking Broadway jobs like she used to. So she decided to take a year off. According to Stritchs biographer, Alexandra Jacobs, her first plan was to unravel her reputation as a lush by finally, at thirty-nine years old, taking up hobbies that were healthybicycling, learning to play piano. But the call of New York night life was too loud. When a scene-y restaurant named Elaines opened on the Upper East Side, Stritch began to haunt it; several show-biz folk began to joke that it was named for her. (The actual namesake was the proprietress, Elaine Kaufman.) One night, a bartender called in sick, and a customer ordered a brandy stinger. Stritch, announcing that this was her specialty, leapt behind the bar, where she stayed on for several months, razzing celebrity guests (Shelley Winters, Toots Shor, Jackie Gleason) and regaling patrons with the kind of warts-and-all backstage tales that she would later turn into the bravura monologue Elaine Stritch: At Liberty. Sparkling details such as these clink around Jacobss biography, Still Here, like ice in a rocks glass. Stritch, who died in 2014, was a true character, full of piss and vinegar, as Gleason said. It would be possible to write a serviceable book about her life by simply quoting her many one-liners, or by describing her habit of wearing only tights on stage. But Jacobs, an editor of the Styles section of the New York Times, doesnt rely on Stritchs charm to fuel the narrative. Instead, she uses hundreds of interviews and years of research to portray the actress in all her complexity. Stritch was a star but a pill, a life force with a self-destructive streak, a mesmerizing presence who also tended to push away those closest to her. The one time I met her, she yelled at me. I considered it an honor. Rachel Syme

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The New Yorkers Favorite Nonfiction Books of 2019 - The New Yorker

Good Economic Theory Focuses on Explanation, Not Prediction Frank Shostak (12/19/2019) – WallStreetWindow.com

In order to establish the state of the economy, economists employ various theories. Yet what are the criteria for how they decide whether the theory employed is helpful in ascertaining the facts of reality?

According to the popular way of thinking, our knowledge of the world of economics is elusive it is not possible to ascertain how the world of economics really works. Hence, it is held the criterion for the selection of a theory should be its predictive power.

So long as the theory works, it is regarded as a valid framework as far as the assessment of an economy is concerned. Once the theory breaks down, the search for a new theory begins.

For instance, an economist forms the view that consumer outlays on goods and services are determined by disposable income. Once this view is validated by means of statistical methods, it is employed as a tool in the assessments of the future direction of consumer spending. If the theory fails to produce accurate forecasts, it is either replaced, or modified by adding some other explanatory variables.

Again on this way of thinking the tentative nature of theories implies that our knowledge of the world of economics is elusive. Since it is not possible to establish how things really work, then it does not really matter what the underlying assumptions of a theory are. In fact anything goes, as long as the theory can yield good predictions. According to Milton Friedman,

The relevant question to ask about the assumptions of a theory is not whether they are descriptively realistic, for they never are, but whether they are sufficiently good approximation for the purpose in hand. And this question can be answered only by seeing whether the theory works, which means whether it yields sufficiently accurate predictions.1

The popular view that sets predictive capability as the criterion for accepting a theory is questionable.

We can say confidently that, all other things being equal, an increase in the demand for bread will raise its price. This conclusion is true, and not tentative. Will the price of bread go up tomorrow, or sometime in the future? This cannot be established by the theory of supply and demand. Should we then dismiss this theory as useless because it cannot predict the future price of bread? According to Mises,

Economics can predict the effects to be expected from resorting to definite measures of economic policies. It can answer the question whether a definite policy is able to attain the ends aimed at and, if the answer is in the negative, what its real effects will be. But, of course, this prediction can be only qualitative.2

Economic theory should be able to explain economic activity. However, statistical methods are of no help in this regard. All that various statistical methods can do is just compare the movements of various historical pieces of information. These methods cannot identify the driving forces of economic activity. Contrary to popular thinking, economics is not about gross domestic product (GDP), the consumer price index (CPI) or other economic indicators as such, but about human beings that interact with each other. It is about activities that seek to promote peoples lives and well-being.

One can observe that people are engaged in a variety of activities. For instance, one can observe that people are performing manual work, they drive cars, and they walk on the street and dine in restaurants. The distinguishing characteristic of these activities is that they are all purposeful.

Thus, manual work may be a means for some people to earn money, which in turn enables them to achieve various goals such as buying food or clothing. Dining in a restaurant could be a means to establishing business relationships. Driving a car could be a means for reaching a particular destination. People operate within a framework of means and ends they are using various means to secure ends.

Purposeful action implies that people assess or evaluate various means at their disposal against their ends. At any point in time, people have an abundance of ends that they would like to achieve. What limits the attainment of various ends is the scarcity of means. Hence, once more means become available, a greater number of ends, or goals, can be accommodated i.e., peoples living standards will increase.

Another limitation on reaching various goals is the availability of suitable means. Thus to quell my thirst in the desert, I require water. Diamonds in my possession will be of no help in this regard.

The fact that people consciously pursue purposeful actions provides us with definite knowledge, which is always valid as far as human beings are concerned. This knowledge sets the base for a coherent framework that permits a meaningful assessment of the state of an economy.

For instance, during an economic slump, a general fall in the demand for goods and services is observed. Are we then to conclude that the fall in the demand is the cause of an economic recession?

We know that people persistently strive to improve their life and well-being hence their demand for goods and services is likely to be rising and not declining. Consequently, the decline in general demand is a result of peoples inability to support their demand. Problems on the production side are the likely causes of an observed general fall in demand. Once we have established that the likely causes of the economic slump are associated with supply factors, we can proceed to assess the possible reasons behind this.

The knowledge that people are acting purposefully also permits us to evaluate the popular theory that the motor of an economy is consumer spending i.e., demand creates supply. We know, however, that without means, no goals can be met. However, means do not emerge out of the blue they must be produced first. Hence, contrary to the popular thinking, the driving force is supply and not demand.

Or, for example, to counter an emerging economic slump various experts urge the central bank to increase the pace of monetary pumping. By means of an increase in the money supply growth rate it is held individuals wellbeing is going to be protected. Money however, is not suitable to promote real wealth generation as it can only fulfill the role of the medium of the exchange. On the contrary, an increase in the supply of money is going to undermine the wealth generation process and will set in motion the menace of the boom-bust cycle.

The fact that man pursues purposeful actions implies that causes in the world of economics emanate from human beings and not from outside factors. Thus, contrary to popular thinking, individual outlays on goods are not caused by real income as such. In his own unique context, every individual decides how much of a given income will be used for consumption and how much for investments. While it is true that people will respond to changes in their incomes, the response is not automatic. Every individual assesses the increase in income against the particular set of goals he wants to achieve. He might decide that it is more beneficial for him to raise his investment in financial assets rather than to raise consumption.

One example that Mises liked to use in his class to demonstrate the difference between two fundamental ways of approaching human behavior was in looking at Grand Central Station behavior during rush hour. The objective or truly scientific behaviorist, he pointed out, would observe the empirical events: e.g., people rushing back and forth, aimlessly at certain predictable times of day. And that is all he would know. But the true student of human action would start from the fact that all human behavior is purposive, and he would see the purpose is to get from home to the train to work in the morning, the opposite at night, etc. It is obvious which one would discover and know more about human behavior, and therefore which one would be the genuine scientist3

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Good Economic Theory Focuses on Explanation, Not Prediction Frank Shostak (12/19/2019) - WallStreetWindow.com