The Ag Startup Engine Adds Peterson Genetics to Its Efforts – Agriculture.com

As the ninth member to join the Ag Startup Engine (ASE), Peterson Genetics brings education, mentoring, and financing resources to Iowa entrepreneurs and start-ups focused on agriculture technologies.Here at Peterson Genetics, were excited about seeing the seed of a new idea grow into a successful business, says Mike Peterson, president of Peterson Genetics, Inc. Weve been providing soybean genetics to seed companies across the country for over 30 years, and hope that some of this knowledge can be put to use for the fledgling companies involved in the Ag Startup Engine.

The ASE, which is located at the Iowa State University Research Park in Ames, Iowa, was formed to address two fundamental gaps that prevent ag start-ups and entrepreneurs from being more successful in Iowa: early seed stage investment and organized mentorship from successful Iowa and Midwestern entrepreneurs.Launched two years ago, other ASE membersinclude Veridian Credit Union, Hertz Farm Management, Iowa Farm Bureaus Renew Rural Iowa, Next Level Ventures, Summit Agricultural Group, Ag Leader Technologies, Ag Ventures Alliance, and Peoples Company.Peterson Genetics reflects the heritage of seed industry entrepreneurs that have had such profound impact on the shape of modern agriculture, comments Kevin Kimle, director of the Agricultural Entrepreneurship Initiative at Iowa State University. We are very excited to have Peterson join the founding group of the Ag Startup Engine.The ASE works to provide agricultural entrepreneurs with a structured environment to help them move from a start-up concept to a seed-ready business. Working in partnership with ISUs Startup Factory Accelerator, the program is implementing an infrastructure for mentoring, rapid prototyping, product development, financing, and customer acquisition. ISUs Agricultural Entrepreneurship Initiative assisted in the creation and development of the ASE, which then advanced into a private sector entity governed by its members.Peterson not only brings his business expertise, but also his strong desire to foster entrepreneurship in agriculture, says Joel Harris, codirector of the ASE. If you want to succeed in starting an ag tech-focused venture, there is no better place to get started than the Iowa State University Research Park in Ames.

You can learn by visiting the Ag Startup Engine at agstartupengine.com.

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GSK to end neuroscience R&D in China – Chemical & Engineering News

It wasnt long ago that GlaxoSmithKlines Shanghai lab led the firms research efforts in neurological diseases including Parkinsons, multiple sclerosis, and Alzheimers. Now, after years of setbacks in China, the company is ending neuroscience R&D in Shanghai.

Following a portfolio review and prioritization, we have decided to close our neuroscience R&D center in Shanghai and move key programs to our global R&D hub in Upper Providence [Pa.] in the U.S., where they will benefit from colocation with other pipeline R&D programs, GSK says.

GSK announced plans to invest in Shanghai in 2007, saying it would build Chinas largest R&D center operated by a multinational drug firm. To focus on neurological disorders, the center was to be staffed by hundreds of scientists under the guidance of Jingwu Zang, a leading multiple sclerosis researcher.

In 2013, however, GSK fired Zang after a paper he coauthored and published in Nature Medicine was found to contain mislabeled data. At the time, Zang vehemently denied research fraud and claimed that he and coauthors had made an inadvertent error. After the firing, GSK was soon embroiled in a much greater controversy.

After a long saga that included the discovery of video cameras in the bedroom of the companys China head, GSK apologized in September 2014 and paid a fine of $500 million to the Chinese government for bribing doctors to prescribe the companys drugs. The following year GSK laid off 110 of its China staffers for alleged ethical violations.

Last year, Min Li, who replaced Zang as head of neuroscience in Shanghai, publicly stated that GSK remained committed to its China neuroscience research. By setting up our R&D structure in this way, we are committed not only to patients in China but also to talent in China, the newspaper China Daily quoted him as saying.

Despite the retreat from neuroscience, drug R&D will go on in China, GSK insists. The China R&D development organization will continue to be based in Shanghai and is set to expand over the next two years to accelerate the development of new medicines, the firm says. We remain committed to China and will focus our R&D efforts in China on the needs of China, at both our Shanghai site and our Institute for Infectious Diseases & Public Health in Beijing.

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Sexual neuroscience PhD: The engineer who wrote the ‘Google memo’ is right – The College Fix

James Damore got fired from Google because the highly educated engineer(with a PhD in systems biology from Harvard) said biology appears to play some role in the career pursuits of men and women, including at Google.

He has the right enemies, and the right allies.

Human sexuality science writer Debra Soh, who has a PhD in sexual neuroscience from York University, writes in The Globe and Mail that Damores internal memo was fair and factually accurate.

She points to studies that show higher levels of prenatal testosterone (typical in boys) are associated with a preference for mechanically interesting things and occupations in adulthood, including in girls with a certain genetic condition:

When they are born, these girls prefer male-typical, wheeled toys, such as trucks, even if their parents offer morepositive feedbackwhen they play with female-typical toys, such as dolls. Similarly, men who are interested in female-typical activities were likely exposed to lower levels of testosterone.

As well, newresearchfrom the field of genetics shows that testosterone alters the programming of neural stem cells, leading to sex differences in the brain even before its finished developing in utero.

One of the most cited studies that found male and female brains cant be differentiated by sex has been refuted byfour yes,fouracademicstudiessince, Soh writes.

She echoes Damores point that group traits dont dictate preferences for any given individual, but its ignorant to claim group traits simply dont exist:

In fact, research has shown that cultures with greater gender equity have larger sex differences when it comes to job preferences, because in these societies, people are free to choose their occupations based on what they enjoy.

Contrary to what detractors would have you believe, women are, on average, higher in neuroticism and agreeableness, and lower instress tolerance.

She scolds the witch hunt leaders who went after Damore for denying biological reality and being content to spend a weekend doxxing a man so that he would lose his job.

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Neuroscience Studies About Happiness | POPSUGAR Smart Living – POPSUGAR

There's a ton of "helpful" advice floating around the internet, but when the tips come from a neuroscientist, it might be time to actually listen up. Ladders, a job platform site, put together some insights from neuroscientist Alex Korb's book The Upward Spiral on how you can be happier based on brain research.

If you're feeling a negative emotion like sadness or anger, label that emotion. It may seem simple, but your brain responds when you put your feelings into words. One fMRI study cited in the book noted that when a participant was shown images of people expressing emotions on their faces, their amygdala activated to the emotions they were seeing. When they were told to name the emotion, "the ventrolateral prefrontal cortex activated and reduced the emotional amygdala reactivity." This essentially means that when participants consciously recognized the emotions they were seeing, it reduced the impact of those emotions in their brains.

Reddit user letstablethisfornow noted the effect labeling their emotions has had on their own happiness, calling it a "a game changer" for them.

"It's so simple and yet has such a profound effect that I'm amazed this isn't taught in schools. The effect is subtle since you are not actually removing the emotion, you just take one step away from it intellectually. You find that from experiencing long drawn-out swings in emotion you tend to have short peaks and valleys with a nice equilibrium most of the time.

You also realize that for the most part our day-to-day emotions are not really connected to anything specific. It could be caused by anything. That outburst at your wife, coworker, or boss could be the end result of waking up with a headache, indigestion, or forgetting you keys on your way to work. We tend to construct stories in our minds as to what our emotions mean after the fact when in reality we have no clue. When you label, you become more aware of your emotions, don't get carried away with them, and will be less likely to fall into this trap."

In The Upwared Spiral, Korb says that the benefits of gratitude "start with the dopamine system, because feeling grateful activates the brain stem region that produces dopamine. Additionally, gratitude toward others increases activity in social dopamine circuits, which makes social interactions more enjoyable." Gratitude can also boost the neurotransmitter serotonin, which is what many antidepressants do. And as The Ladder points out, even if you don't have an answer to the question "what am I grateful for?", that's OK. "It's not finding gratitude that matters most; it's remembering to look in the first place," the book says. "Remembering to be grateful is a form of emotional intelligence." The studies showed that as emotional intelligence increases, the neurons in these areas become more efficient. So even if you have trouble finding something to be grateful for, merely asking yourself the question means you're on the right path to happiness.

"Address the possibility of a blind spot in your mind where you aren't able to instantly know what you take for granted. Spend time simply observing the things you don't have to overcome, all the conveniences and luxuries," says Reddit user Privatdozent. "This 'positive feedback loop' has to loop around many times to have a solid effect. The common criticism of this idea is that 'No one else's struggles diminish your own.' Well, yeah, they don't. But what if you take seriously much more of the struggles than the things deserving of your gratitude? Basically, try to give equal weight to the good things that happen as to the bad."

There's nothing more anxiety-inducing than feeling like you've got unfinished business. Simply making a decision about something can reduce anxiety rather than allowing yourself to spend more time hesitating over all of the scenarios and outcomes that the decision will result in. "Making decisions includes creating intentions and setting goals all three are part of the same neural circuitry and engage the prefrontal cortex in a positive way, reducing worry and anxiety," says Korb. Making decisions also allows people to feel more in control feeling "out of control" can also cause feelings of worry. And when you do make a decision and the outcome of that decision happens to be a positive one, then even better!

"There's a book that's really helped me, called Getting Things Done," says Reddit user Kabitu. "It explains how indecision is a major source of mental stress. When you don't want to make a decision now, and leave the decision to be made later, that builds up a big cloud of annoying mental work you don't want to do, and it can sustain a subconscious reluctance to work."

Social interactions have been proven to increase a person's feelings of acceptance and therefore happiness, but The Upward Spiral takes it a bit further. "One of the primary ways to release oxytocin is through touching," the book says. Oxytocin is a hormone that acts as a neurotransmitter to the brain. Psycholology Today says that it's known as the "love hormone" because it "regulates social interaction and sexual reproduction, playing a role in behaviors from maternal-infant bonding and milk release to empathy, generosity, and orgasm." So when people touch, hug, or kiss others, oxytocin levels actually increase. "Oxytocin is the hormone that underlies trust. It is also an antidote to depressive feelings," says the site. According to Korb, holding hands with someone during a painful experience can comfort you and your brain and help reduce the reaction to pain. So, more hugs!

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Engraved prehistoric human bones show ritualistic cannibalism – Reuters

LONDON (Reuters) - Engravings on a human bone from a prehistoric archaeological site in a cave in southern England shows that human cannibals ate their prey and then performed ritualistic burials with the remains, scientists said on Wednesday.

The forearm bone appears to have been disarticulated, filleted, chewed, and then engraved with a zig-zag design before being broken to extract bone marrow, said scientists from Britain's Natural History Museum who conducted the analysis.

The finding, published in the journal PLOS ONE, adds to previous studies of bones from the site, called Gough's Cave, thought to be from Britain's Palaeolithic period - the early Stone Age.

Those studies confirmed human cannibalistic behavior and showed some remains had been kept and modified, making human skulls into bowls, or "skull cups".

The zig-zag cuts are undoubtedly engraving marks, the scientists said, and had no utilitarian purpose but were purely artistic or symbolic.

Silvia Bello, a Natural History Museum who worked on the study with colleagues from University College London, said the engraved motif was similar to engravings found in other European archaeological sites.

"However, what is exceptional in this case is the choice of raw material - human bone - and the cannibalistic context in which it was produced," she said.

"The engraving was a purposeful component of the cannibalistic practice, rich in symbolic connotations."

Discovered in the 1880's, Gough's Cave in Somerset, southern England, was excavated over several decades ending in 1992.

Archaeological investigations there revealed intensively processed human bones intermingled with butchered remains of large mammals and a range of flint, bone, antler and ivory artefacts.

Reporting by Kate Kelland; Editing by Raissa Kasolowsky

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What Thucydides Teaches Us About War, Politics, and the Human Condition – War on the Rocks

Thucydides is on a roll these days.

The ancient Greek historian of the Peloponnesian War, who lived almost 2,500 years ago, makes the title of Graham Allisons prominent new volume, Destined for War: Can America and China Escape Thucydidess Trap?

The great historian merits this because his analysis of the causes of the ancient war between the Athenians and the Spartans provides the essential dilemma of Allisons book: Can states avoid catastrophic war when a rising power begins to challenge a dominant states control? Thucydides pessimistic answer seems to be No: War was inevitable, we are told, when emergent power Athens contested Spartas supremacy 2,500 years ago. Allison offers only a slightly more optimistic take (War is more likely than not) in analyzing Chinas growing challenge to Americas dominating position globally.

The Trump White House is reportedly obsessed with Thucydides, thanks in good measure to Allison. But senior administration officials like National Security Advisor H. R. McMaster have long taken seriously the ideas of the ancient writer, even if some think he misunderstands what Thucydides is really saying.

And now even Wonder Woman has Thucydides name on her lips: In the recent blockbuster superhero movie, the title character and a villain refer to the historian in a dramatic scene (incorrectly, as it turns out, since a quotation is erroneously attributed to him.)

All this attention, both serious and silly, raises the question: What can we truly learn from Thucydides, a writer who lived over two millennia ago, about power relations today? Quite a bit, in my view, but not necessarily in the way people like to.

This moment is not, of course, the first time modern policy experts have turned to Thucydides for his insights. The cognoscenti have long known of the utility of his history. To take a prominent example, during the Cold War much used to be made of the bipolar world of Thucydides. America was often cast in the role of Athens because both were democracies, while militarized, oligarchic Sparta was played by the Soviet Union. But this analogizing got things backwards in strategic terms: Sparta (much like the United States) led an alliance of relatively free, vulnerable allied states who looked to it for protection against a repressive imperial power. Meanwhile, Athens (much like the Soviet Union) controlled its allies by force or intimidation, causing a great deal of anxiety in the opposing coalition.

But regardless, this attractive bipolar comparison stoked fears that the unavoidable war Thucydides described in his time would mean World War III for all of us.

Happily, it didnt turn out that way.

This brings me to my first point about appropriately using Thucydides history: Be careful about the analogies you see. Thucydides compelling vision of the Peloponnesian War, with its meticulously delineated causes, combatants, and alliances, make it easy to find parallels later in history, right up to the present day. Thucydides clarity about power relations and human behavior in times of conflict gives his readers all the tools they need to see larger patterns at work that they may identify with events in their own times. Thucydides himself foresaw the utility of his work. He says that he wrote it not to entertain for the moment but to be of lasting value, because people could use it to clearly understand past events and also understand future events given that, people being people, similar sorts of things will happen again.

But as we have seen, one can get the analogies wrong. That similar sorts of things may come up again in human affairs (as Thucydides put it) does not mean that everything turns out the same in the end. Thus, the dangerous, decades-long American-Soviet standoff did not result in catastrophic war the way the Athens-Sparta confrontation did. Such a failed analogy doesnt mean Thucydides was wrong, only those who tried to prognosticate based on his text. Thus, we ought not be too eager to seize upon another comparable strategic situation modern Chinas challenge to the United States (equivalent to Athens challenge to Sparta?) and try to use Thucydides to predict the outcome.

Now, to be fair to Allison, Destined for War does not go quite this far. He is more cautious. For one thing, like a good political scientist, he expands his dataset beyond Thucydides to include 16 other, supposedly comparable, cases of rising versus established powers from various periods in history. In 12 of these, he says, war resulted and in four it did not. Moreover, his goal is not really to make a prediction. Rather, he wants to use what he identifies as the Thucydides trap the tendency for wars to break out in circumstances like Chinas growing challenge to U.S. dominance to put Americans on guard to the danger and encourage policymakers to take appropriate action, including embarking on a long-term strategic reassessment.

And yet the risk of misunderstanding Thucydides remains when he is used this way, however carefully. First, we should understand that Thucydides himself never talks of a trap. Thats a modern construal, not just by Allison but by Arlene Saxonhouse, when she asserts that, reading Thucydides history, we see a Power Trap described, whereby states like Athens become trapped by their unending pursuit of power. But Thucydides never describes the complex strategic history of his time as any kind of paradigm or trap. He never warns that this set of circumstances may occur again and that we all must be on guard for it in the future. To use his history as if he did risks turning it into a kind of parlor game of potentially predictive analogies. I see 19th century England in ancient Athens! No, Athens is 21st century America! No, Sparta is! We better watch out look what happened in the Peloponnesian War!

So how should we use Thucydides, then? Does his history have anything valuable to offer modern thinkers or policymakers? It certainly does, and this brings me to my second point. Years of working with Thucydides in the classroom and as a scholar tell me that what his book teaches most of all is what we might call historical mindfulness. By this I mean a generalized understanding about the workings of history: what kinds of forces tend to inspire people, drive politics, create crises and bring (or prevent) resolution, with what consequences for human communities? Thucydides was not a prophet nor a political scientist, but a keen observer and explicator of the human condition in collective conflict. And we can gain much wisdom by studying his work with this in mind.

For example, when we read Thucydides account of the devastating civil war in Corcyra, with his astute observations of the way political struggles of this kind twist ambitions and norms and the very meaning of words, there is much to learn. The horror and tragedy of the events in Corcyra friends become enemies, kin kill kin, a once-prosperous polity virtually self-destructs make his account riveting and give weight to his thoughts on how such things can come about. Several of his observations stand out: that the existence of a larger war (between Athens and Sparta) paved the way for Corcyra and, later, other polarized cities to fall into internal violence; that political behavior previously honored as prudent and honest becomes, in these circumstances, scorned as disloyal or cowardly; that atrocity led to counter-atrocity, while mutual distrust made de-escalation almost impossible. Seeing the truth in Thucydides observations about events in Corcyra (which, in general ways, recall incidents from other civil wars in other times and places) can teach us a great deal about civil strife and of politics gone wrong. It helps make us historically mindful.

This manner of reading Thucydides offers, I would assert, a deeper wisdom than analogy-hunting. (The Corcyrean oligarchs are like the hardliners in Iran! No, they are the loyalists in Syria! And the Corcyrean populists must be the Syrian Kurds! Now we can predict what will happen!)

Consider another example. One of the most renowned parts of his history is the Melian dialogue, where Thucydides reports on a conversation that took place between envoys from an invading Athenian force and officials from the small island city-state of Melos, which the Athenians were about to assault. In the dialogue, Thucydides presents his readers with a stark view of the Athenian imperial mindset of the time, while also putting us in the shoes of a vulnerable community that found itself in the path of a much more powerful one bent on swallowing it. The Melians ask the envoys to be left alone, appealing to reason and justice. They claim a desire to remain neutral in the Spartan-Athenian struggle, contend that the Athenians would outrage gods and men if they attacked them, and warn that the Spartans would intervene on the Melians behalf. The Athenians, in contrast, argue from a basis of naked power: We will forego fancy words of self-justification and simply tell you that we are strong, you are weak, and you can only save yourself by surrendering your freedom to us or we will crush you. Our empire was built by taking what we can and thats how we will maintain it. Oh, and the gods seem to like us just fine. (And dont delude yourselves about Sparta coming to help you; it is obvious that they wont.)

The contrast between the harsh words of the Athenians and the alternately brave, hopeful, and desperate arguments of the Melians makes this exchange one of the most memorable in Thucydides history. The fact that the Melians, who refused to surrender and resisted the Athenian siege for as long as they could, suffered obliteration in the end at the hands of the Athenians (all surviving men were executed, all the women and children were sold into slavery) adds to the drama and message of the episode. Thucydides follows his Melian account with a lengthy description of Athens grand Sicilian expedition. This was another arrogant attempt at imperial expansion, but one that instead ended in disaster for Athens.

Scholars have argued about how exactly we should interpret the Melian dialogue, but two conclusions seem fairly clear. First and foremost, Thucydides wants us to see the brutal thinking and overbearing pride of the Athenians in the way they conceived of and sought to expand their empire. Fair-seeming words used on other occasions to justify ethically their imperial expansion are stripped away, revealing the cold calculus beneath. Thucydides moralizing purpose shines through, both in the painfully unjust treatment of the honorable Melians and in the comeuppance that he shows the overconfident Athenians suffering in the immediately following narrative of the catastrophic Sicilian expedition. Naked, cruel aggression can rebound against its practitioners.

But there is more to it than this. Thucydides is also teaching us about realistic expectations in dangerous times. The Melians, for all the justice of their cause, made a terrible error in deciding to resist the Athenians. The Spartans did not lift a finger to help them, much as the Athenians predicted. The Melian forces were completely outmatched, much as the Athenians said they would be. And the Melians paid for their delusions with their very existence.

I could produce many more fertile episodes for examination from Thucydides ample history. There is, for example, his famous multifaceted treatment of the short- and long-term causes of the Spartan-Athenian war (on which see S. N. Jaffes recent and wise commentary in War on the Rocks.) But the expositions I have provided, brief as they are, show, I hope, how contemplating Thucydides rich text can yield many insights about fundamental matters of politics, war, and the human condition. We can see in Thucydides work (and, of course, in written accounts of other times and places, if not always as incisively) the dynamics of history at work. Understanding the predicament of the Melians, or the civic self-immolation of the Corcyreans, or the corrosive imperial ideology of the Athenians, together with the long-term causes and consequences of their conflicts, helps one to perceive, at a general level, how human communities can prosper or falter or fail. Guided by Thucydides, we see dynamics at work that can facilitate the analysis of strategic confrontations in any era.

Fostering such historical mindfulness does not, unfortunately, grant one the straightforward ability to predict the course of future events. Neither does Thucydides history itself. He did not write an oracular text. Trying to peg the Chinese or Americans as latter-day Athenians, or distilling Thucydides work into axioms of history (when x power challenges y, z will result) while, admittedly, intellectually stimulating misses a more profound education available in his text, an education that can provide students of public affairs with a nuanced, historically grounded grasp of how the world works.

Eric W. Robinson is Professor and Director of Graduate Studies in the Department of History at Indiana University. His most recent book is Democracy Beyond Athens: Popular Government in the Greek Classical Age (Cambridge, 2011). He has written about Thucydides and causes of the Peloponnesian War in The Oxford Handbook of Thucydides (Oxford, 2017).

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The Anatomy Of An Oil Market Evolution, Its Sustainability, And Consequences – Seeking Alpha

World oil markets have experienced a fundamental transition in recent years, making the practice of oil price manipulation to be elusive. In the past, oil prices were basically supported by the market being undersupplied, together with the specter of peak oil. Oil market paradigms were based on declining production in countries composing the Organization for Economic Co-operation and Development (OECD), contrasting with rising global demand mostly among non- OECD countries. In the face of such production declines, OPEC and Eurasia (Russia and the former United Soviet Social Republics, U.S.S.R) pegged their production to quotas more so associated with global supply than global demand. The resulting anticipation was for a state of secular market undersupply to simply continue, pushing oil prices higher.

However, oil prices collapsed. Market expectations were defeated with the U.S. dramatically increasing production. The production increase in the U.S. shocked markets by demonstrating the capacity to supply 78% of the total global oil demand increase from 2008 to 2015. Something never before experienced from a country or entity in the oil markets. OPEC and Eurasia market quotas, associated with global supply, cemented an oversupplied dynamic.

This oversupply was once thought to be self limiting with U.S. producers simply having to shut in production at various declining price levels. 2016 proved this not to be the case. Now, OPEC and Russia seek to regain influence in an oil market that's dramatically altered. Altered in such a way that the past method of controlling prices by controlling supply has simply given way to new technologies. These technologies evolved an oil market where the ability to accumulate market share at historically low prices is paramount. Driving this is that oil production trends have been much more dramatic than trends in oil demand, with both trends favoring oversupplied conditions. Technology is creating the ability to produce more oil at progressively cheaper costs. Likewise, technology reduces oil demand by creating fuel inefficiencies and alternative modes of energy.

Another transitional market dynamic is looming between a state of oversupplied conditions and sovereign budget deficits. Where OPEC countries once enjoyed significant sovereign budget surpluses and associated social services, now worrying budget deficits have persisted since 2014. To bridge the gap, unprecedented bond debt has been issued among the most able, namely Saudi Arabia, with there $17.5 billion global bond issuance in October of last year. The primary method of addressing deficits has been the use of foreign currency reserves, such as in Iraq to fill an approximate $20 billion per year short fall over the last 3 years. All of this in a region already inflicted with substantial ideological tensions, insurgencies and territorial conflicts.

OPEC once balanced production between supporting prices while avoiding global economic recession. Now, we see OPEC pressured in an unprecedented way with private company profitability setting oil price discovery. A collapse in OPEC production is the risk as always, but now it is compounded by the new economics of oil price due to technology, and not just the customary features of ideology and territory.

According to data from the United States' Energy Information Administration (EIA), from 2007 through 2013, global markets were undersupplied with oil 4 years out of the total 7 years. The undersupply was often significant with an undersupply of 1.4 million barrels per day(mb/d) in 2007 and 1.24 mb/d in 2011. In 2012 an oversupply of only 140 thousand barrels per day (kb/d) occurred. In 2009 and 2010, the market was essentially balanced with demand having been eroded by the Great Recession.

In the singular instance of oversupply, the volume of oversupply was minimal. This dynamic supported inflation adjusted oil prices in the range of $90 to $105 per barrel. A shift to oversupply came in 2014 with an oversupply of 820 kb/d, gaining to 1.71 mb/d in 2015 and 250 kb/d in 2016. So far in 2017, the first quarter saw a state of balance and second quarter saw an undersupply of 270 kb/d, primarily attributable to a large decline in Canadian production due to an unscheduled disruption in operations. Of course it was in the second half of 2014 that oil prices began their collapse as the basic premise of maintaining an undersupplied market showed failure.

Basic to explaining this shift in supply is shale and tight oil production in the U.S. For decades, oil production in the U.S. had been in decline until technology opened a new chapter. Chevron's 10-K for 2016 explains the oil industry's new approach to production by using the Permian basin as an example. According to Chevron, the "Permian has multiple stacked formations that enable production from several layers of rock in different geological zones." This allows "for multiple horizontal wells to be developed from a single well pad location using shared facilities and infrastructure..."

Such a compounding of wells on a single well pad, near shared facilities and infrastructure, largely explains the countervailing premise of historical oil market dynamics.

The EIA tracks oil production data in a variety of ways. One such way is by tracking production of "petroleum and other liquids," which is similar to barrels of oil equivalents. I will reference this EIA data as barrels of oil equivalents per day (boe/d). In 2009, as the new production technologies were being launched, U.S. production jumped by 630 kboe/d to 9.14 mboe/d, an increase of 7.4% over 2008's level of 8.51 mboe/d. U.S. production increased at similar rates until 2012 when the increase was 980 kboe/d to reach 11.11 mboe/d, an increase of 9.7% over 2011 levels. 2013 saw the U.S. rate of production brake the one million mark by increasing by 1.23 mboe/d, 2014 was a banner year with a production increase of 1.73 mboe/d, and 2015 saw a per day increase of another 1.05 mboe/d.

With multiple years of increasing production by over a million barrels per day, and nearly 2 million barrels per day in 2014, U.S. total production found itself at 15.12 mboe/d in 2015. This reflects a 77.6% increase in U.S. oil production from a 2008 level of 8.51 mboe/d. Over 7 years, the U.S. increased its production by a remarkable 6.61 mboe/d.

From 2008 to 2015, total global oil production went from 85.37 mboe/d to 95.78 mboe/d, an increase of 10.41 mboe/d. Of this increase in supply, the U.S. accounted for 6.61 mboe/d, or 63.5% of the increase in total global supply. Over the same period, the largest oil producer, OPEC, saw their production go from 35.72 mboe/d in 2008 to 38.31 mboe/d in 2015, an increase of only 2.59 mboe/d. Most of OPEC's increased production was in 2015 with an increase of 1.96 mboe/d. Still, OPEC's share of total increased global supply was only 24.8%. If one considers that global oil production grew by 10.41 mboe/d between 2008 and 2015, and increased production from both the U.S. and OPEC totaled 9.2 mboe/d, the combined increase in supply from the U.S. and OPEC accounted for 88% of the total increase in global supplies.

Eurasia once was the second largest oil producer behind OPEC, but this changed in 2014 with the progressing evolution of U.S. production. In 2008, Eurasia produced 12.52 mboe/d contrasting with the U.S. producing 8.51 mboe/d. By 2015, Eurasia's production advanced to 14.10 mboe/d while U.S. production saw 15.12 mboe/d. This resulted in Eurasia production growing by a small 1.58 mboe/d from 2008 to 2015, which is only 15% of the total growth in global production of 10.41 mboe/d.

If one combines U.S., OPEC and Eurasia production increases, the three grew production from 2008 to 2015 by 10.78 mboe/d while total global production increased at a smaller rate of 10.41 mboe/d. This numerical discrepancy shows that production from the above three assisted in offsetting production declines in other areas such as the North Sea having a decline of 1.24 mboe/d and Mexico declining by 570 kboe/d. Add in Canadian production increasing by 1.46 mboe/d, together with minor advances and declines in other areas and one can see that the increase in U.S. production of 6.61 mboe/d fundamentally altered the global oil market.

From 2009 through 2011, U.S. oil production steadily crept higher, gaining by about 500 kboe/d. That rate of production doubled in 2012, hitting nearly one million barrels per day of new oil that previously wasn't anticipated. OPEC generally keeps its share of total global production at about 40%, Eurasia similarly keeps its share in the 15% range. The U.S. on the other hand, expanded its share of total global production from 9.9% in 2008 to 15.8% in 2015. In so doing, the U.S. accounted for 63.5% of the increase in total global supply, and is the essential reason for the increase in global supply.

Looking at the demand side of the equation, production in the U.S. appears to have averted a looming energy crises. In so doing, a progressing undersupply imbalance was corrected, at the expense of high oil prices. In 2008, total global consumption stood at 85.78 mboe/d and reached 94.07 mboe/d by 2015, resulting in an increase of 8.29 mboe/d. Of course total global oil supply increased by 10.41 mboe/d over this period, showing an oversupply of 2.12 mboe/d. This oversupply assisted in compensating for more periods of substantial undersupply than rare periods of meager oversupply.

With the U.S. increasing its production by 6.61 mboe/d from 2008 to 2015, and total global demand increasing by 8.29 mboe/d, the increase in U.S. production addressed 78% of the increase in global demand and, together with OPEC and Eurasia production, an oversupply resulted. Over the 7 years prior to 2008, an opposite dynamic prevailed where supply grew by 7.6 mboe/d and demand grew by 10.3 mboe/d, with an undersupply of 2.7 mboe/d. Undersupply was the essential premise of oil markets, and when the U.S. shale revolution became apparent as a continuing development, prices collapsed.

Originally it was assumed that the oversupplied condition would be self correcting. That is, the falling price of oil due to changes in market dynamics would inevitably weed out U.S. shale production. However, as observed by Chevron's John Watson in his Q4 2016 earnings call, "I have been surprised at how resilient production has been in many locations around the world[,] some of that is we just keep getting better."

One such location of production resiliency is certainly the U.S. In January 2016, the EIA projected that U.S. petroleum production would fall into a run rate of 14.5 mboe/d and stay there, if not go lower, through 2017. This contrasts with a run rate in the 15.20 mboe/d range seen in 2015, a decline of 700 kboe/d. By June 2016, the EIA projected U.S. production to fall as low as 14.22 mboe/d, a decline of 980 kboe/d versus 2015 levels. Interestingly, EIA projected continuation of oversupply through 2017 despite projections of significantly declining U.S. production. The essential reason was forecasts of OPEC increasing production thereby offsetting U.S. declines. It wasn't until December of 2016 that OPEC resolved to cut production by 1.8 million barrels of crude per day. The reason: By December of 2016, both OPEC and the EIA had recognized the resiliency of U.S. production.

Though U.S. production did decline, it didn't do so to the extent thought. U.S. production consistently defeated projections to the upside throughout 2016 by around 200 kboe/d. Ultimately U.S. production decreased by only 290 kboe/d compared with 2015, despite oil prices rarely exceeding $50 per barrel, going as low as $27 and ranging between $50 and $40. In 2016, the market remained oversupplied by 350 kboe/d, assisted by OPEC increasing its production by 610 kboe/d.

OPEC's agreement in late 2016 to cut production by 1.8 mb/d boosted oil price optimism. But the agreement was more so a last ditch response to OPEC's disappointed expectations of U.S. shale production collapsing. Through the first half of 2016 both OPEC and the EIA projected declining U.S. production, with OPEC's expectations being much more aggressive. In the second half of 2016, it became apparent that U.S. shale production could function in an environment of sustained low pricing. Consequently the EIA began to revise up projections for U.S. production.

Currently, U.S. production has returned to the upward trajectory previously witnessed. In January 2017, the EIA projected U.S. first-quarter production to be 14.76 mboe/d, the actual production was 15.01 mboe/d. Same with the second quarter where the projection was 15.04 mboe/d with an actual rate of 15.36 mboe/d. By the fourth quarter of this year, the EIA projects U.S. production to reach 16.24 mboe/d, exceeding the high mark reached in 2015 of 15.20 mboe/d. OPEC is also projected by the EIA to exceeds previous records of production by reaching 39.91 mboe/d by the end of 2017.

The EIA forecasts a balanced oil market this year, going into moderately oversupplied next year. However, such a forecast for 2017 looks to be based essentially on flat Canadian production. Since the rescission, Canada has consistently increased production. In the fourth quarter of 2016, their production reached 4.95 mboe/d and was at 4.92 mboe/d in the first quarter of 2017. In the second quarter of 2017, production fell to 4.52 mboe/d due to disruptions arising from a fire at Suncrude Canada Ltd.'s bitumen processing plant. For the third and fourth quarters of 2017, the EIA is projecting Canadian production to be at 4.78 mboe/d. Given Canada's history of increasing production and given a production rate of 4.9 mboe/d prior to the second quarter disruption, it appears more likely that Canadian production will reach the 5.0 mboe/d level. Such an event would result in a slightly oversupplied market for 2017.

OPEC's production cuts are showing signs of declining enthusiasm. June's compliance rate decline to 78% versus high 90% rates in previous months. There is a market dynamic at play which OPEC has yet to address, at prices more so implying the need for difficult social transition than simply the margin efficiencies obtained by private oil companies.

Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.

I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

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The Anatomy Of An Oil Market Evolution, Its Sustainability, And Consequences - Seeking Alpha

13 Grey’s Anatomy characters we definitely don’t miss – Hidden Remote

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Photo Credit: Greys Anatomy/ABC Image Acquired from ABC Studios Press

All TV shows have those characters that fans hate with a passion, including Greys Anatomy. Or there are characters that just dont seem to be interesting or vibrant enough to gain a lot of love. These characters leave with either little fanfare or with fans cheering for their demise. Its a shame that actors are no longer working on the show, but the characters certainly do not end up missed.

On the odd occasion, an unlikable character does get an emotional and well-created exit. We can be left wondering if there could have been something more, but a rewatch of an episode reminds us of why we hated that character with a passion.

With the news that a certain character is not returning to the show, I cant help but think about how much I wont miss her. A lot of fans feel the same, and its brought up the question of other characters we dont really miss from the show.

There are a lot of reasons why we dont miss a character inGreys. Sometimes its because they were just hateful characters but others are due to poor writing or lack of dimensions. In some cases, their storylines came to a natural end and theres no reason to have them back.

Heres a look at 13 Greys Anatomy characters that we definitely do not miss from the show.

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13 Grey's Anatomy characters we definitely don't miss - Hidden Remote

Grey’s Anatomy: Will Jackson and Maggie really get together? – EW.com (blog)

A new romance might be in the air when Greys Anatomy returns.

After the season 13 finale hinted at a potential romance for Jackson (Jesse Williams) and Maggie (Kelly McCreary), fans of the ABC medical drama have spent the hiatus wondering if Japril is out and Jaggie Mackson? is in. April (Sarah Drew) pointed out the potential in the finale, telling Maggie she believes her ex-husband and the cardio doc who grew close when Jackson treated Maggies dying mother have feelings for one another.

What April said to her literally had not crossed her mind, so I think its a question shes grappling with whether theres any truth to that, and if there is, what to do with it, and if theres not, how to manage if theres truth for Jackson in that, McCreary tells EW. Shes on fertile ground trying basically to find out whether April was onto something shes unaware of.

When Greys Anatomy returns this fall, the series will pick up right where the finale left off following the hospital explosion, which means Aprils words will still be ringing in Maggies ears. So, will Maggie take a shot with Jackson? The truth is that still remains to be seen, McCreary says. Whats ironic is that all of the reasons the fans might not want Jackson and Maggie to get together are the exact things that make really great drama. Thats true of life, too, the stuff that makes things a little bit messier is the stuff we think we dont want, but ultimately makes us stronger, so if thats where it goes, then theres probably good story to mine and good lessons to teach there about humanity and god knows what else.

And if it doesnt go there, McCreary continues, theres still so much potential in that relationship because Jackson and Maggie havent spent a lot of meaningful time together, April and Maggie havent spent a lot of meaningful time together those are new relationships that are absolutely as worthy of exploration as Amelia and Maggie and Meredith and Maggie, so why not?

Greys Anatomy returns with a two-hour premiere on Thursday, Sept. 28 at 8 p.m. ET on ABC.

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Grey's Anatomy: Will Jackson and Maggie really get together? - EW.com (blog)

New Microscope Technique Reveals Internal Structure of Live Embryos – R & D Magazine

University of Illinois researchers have developed a way to produce 3-D images of live embryos in cattle that could help determine embryo viability before in vitro fertilization in humans.

Infertility can be devastating for those who want children. Many seek treatment, and the cost of a single IVF cycle can be $20,000, making it desirable to succeed in as few attempts as possible. Advanced knowledge regarding the health of embryos could help physicians select those that are most likely to lead to successful pregnancies.

The new method, published in the journalNature Communications, brought together electrical and computer engineering professorGabriel Popescuand animal sciences professorMatthew Wheelerin a collaborative project through the Beckman Institute for Advanced Science and Technology at the U. of I.

Called gradient light interference microscopy, the method solves a challenge that other methods have struggled with -- imaging thick, multicellular samples.

In many forms of traditional biomedical microscopy, light is shined through very thin slices of tissue to produce an image. Other methods use chemical or physical markers that allow the operator to find the specific object they are looking for within a thick sample, but those markers can be toxic to living tissue, Popescu said.

"When looking at thick samples with other methods, your image becomes washed out due to the light bouncing off of all surfaces in the sample," said graduate student Mikhail Kandel, the co-lead author of the study. "It is like looking into a cloud."

GLIM can probe deep into thick samples by controlling the path length over which light travels through the specimen. The technique allows the researchers to produce images from multiple depths that are then composited into a single 3-D image.

To demonstrate the new method, Popescu's group joined forces with Wheeler and his team to examine cow embryos.

"One of the holy grails of embryology is finding a way to determine which embryos are most viable," Wheeler said. "Having a noninvasive way to correlate to embryo viability is key; before GLIM, we were taking more of an educated guess."

Those educated guesses are made by examining factors like the color of fluids inside the embryonic cells and the timing of development, among others, but there is no universal marker for determining embryo health, Wheeler said.

"This method lets us see the whole picture, like a three-dimensional model of the entire embryo at one time," said Tan Nguyen, the other co-lead author of the study.

Choosing the healthiest embryo is not the end of the story, though. "The ultimate test will be to prove that we have picked a healthy embryo and that it has gone on to develop a live calf," said Marcello Rubessa, a postdoctoral researcher and co-author of the study.

"Illinois has been performing in vitro studies with cows since the 1950s," Wheeler said. "Having the resources made available through Gabriel's research and the other resources at Beckman Institute have worked out to be a perfect-storm scenario."

The team hopes to apply GLIM technology to human fertility research and treatment, as well as a range of different types of tissue research. Popescu plans to continue collaborating with other biomedical researchers and already has had success looking at thick samples of brain tissue in marine life for neuroscience studies.

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New Microscope Technique Reveals Internal Structure of Live Embryos - R & D Magazine