Biochemist Studies How Viruses Replicate, Cause Infection – CSUF News

Biochemist Marcos E. Ortega, a native of El Paso, Texas, studied how viruses replicate at the University of Colorado Denver and Health Sciences Center, where he earned a doctorate in biochemistry. Following postdoctoral fellowships at USC and Harvey Mudd College, he landed a teaching position in 2013 at Macalester College in St. Paul, Minnesota.

This fall semester, he joins Cal State Fullerton as an assistant professor of chemistry and biochemistry. Ortega also holds a bachelor's degree in chemistry from Grinnell College in Iowa.

"I chose to pursue a career in academia as I truly love the combination of teaching and research," said Ortega, who also speaks Spanish. "I wanted to pursue a path that allowed me to impact the community and students in a very personal way through teaching, mentoring, outreach and service work."

I was inspired to pursue biochemistry and education by two things: the passing of my grandfather from diabetes when I was a teen and the teaching career of my mother. When I chose to pursue chemistry in college, it was biochemistry and the molecular origins of disease that piqued my interest the most. I sought answers in biochemistry about diabetes, which helped me to deal with the loss of my grandfather. It was truly a case where knowledge was power, and I utilize these lessons to this day in my classes. I was also inspired by the patience and significant impact that my mom had on students as a first-grade teacher. I want to have that same type of impact on others and a career in academics married my desire to impact students with the molecular understanding and prevention of disease and infection.

My research interests lie in trying to understand viral infection and viral replication using biochemical techniques and studies. I seek to understand how biophysical and biochemical principles guide the spontaneous assembly of a mature virus in a host cell. At the core, I want to investigate how viruses replicate and assemble and thus cause infection by studying the relation between protein structure and function.

I hope students learn that biochemistry is important to all people and impacts our lives on a daily basis. I want students to find a personal connection to biochemistry that hopefully motivates them to learn more. I also want students to find their place in the world and realize the importance of education. I know all students will not pursue biochemistry or biophysics, but through my teaching, I want students to know that anything is possible with a strong work ethic and an education.

I would like people to know that the answers to many of the difficult questions in todays world may be right in front of us. Whether its treatments for cancer, feeding the hungry, environmental issues or sustainable energy, the foundations of cellular function and the chemistry that drives it may begin to illuminate some answers that will help us prosper and advance as a society.

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Biochemist Studies How Viruses Replicate, Cause Infection - CSUF News

Lopez named Vanderbilt’s liaison to Oak Ridge National Laboratory – Vanderbilt University News

by Erin Facer | Wednesday, Aug. 30, 2017, 11:54 AM

Carlos Lopez (Vanderbilt University)

Carlos F. Lopez, assistant professor of biochemistry and biomedical informatics, has been appointed as Vanderbilt Universitys liaison to Oak Ridge National Laboratory, the U.S. Department of Energys largest science and energy laboratory conducting research in energy and security. Lopez will continue the many collaborations that Greg Walker, associate professor of mechanical engineering, initiated during his term in this role.

Carlos expertise at the interface of physical, biological and computer sciences is precisely what is needed to help Vanderbilt University develop closer scientific collaborations with Oak Ridge National Lab, Vice Provost for Research Padma Raghavan said. I am grateful to him for stepping into this role, and I look forward to working with him to further develop this important partnership.

Carlos is an energetic and interactive investigator who already has productive collaborations with Oak Ridge scientists. He is very well suited for this new role, added Larry Marnett, dean of basic sciences at the School of Medicine.

As the Vanderbilt liaison to ORNL, Lopez will work closely with Vanderbilt faculty, the Office of the Provost, university deans and Vanderbilt University Medical Center leadership to advance key research themes that align with both Vanderbilt and ORNL priorities.

I would like to be instrumental in bringing together researchers from both institutions to develop robust collaborations to accelerate discovery, Lopez said.

Lopez received his Ph.D. in physical chemistry from the University of Pennsylvania. He pursued a postdoctoral fellowship at the University of Texas at Austin, where he studied theoretical biophysics, and followed this with a postdoctoral position at Harvard Medical School. He moved to Vanderbilt University School of Medicine in late 2012 as an assistant professor of cancer biology. His work develops and applies novel computational modeling tools and leverages strong experimental collaborations to describe intracellular biochemical signaling networks to further our understanding of cellular decision-making processes.

Media Inquiries: Erin Facer, erin.facer@vanderbilt.edu

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Lopez named Vanderbilt's liaison to Oak Ridge National Laboratory - Vanderbilt University News

Tomatoes’ ‘Crystal Ball’ Reveals Evolutionary Secrets – Laboratory Equipment

Michigan State Universitys Robert Last studies tomatoes. Specifically, he researches their hair, or trichomes.

For this study, he focused on a single type of molecule in trichomes acylsugars. The secrets Last and a team of MSU scientists found from studying these specialized metabolites open an evolutionary window for the emerging field of plant defense metabolism, insights that could lead to engineering advances for better pest resistance and human medicine.

There are an estimated 300,000 species of plants in the world, producing roughly more than a million metabolites. Plants use these molecules to grow, communicate with each other or to defend themselves against pests and disease. Humans benefit from many of these products for food, medicines and industrial uses. Thousands of core metabolites are found in every plant, but hundreds of thousands are more specialized and found only in specific groups of plants.

Acylsugars are an example of a group of specialized metabolites found only in the Solanaceae family, which includes tomato and petunia plants. These specialized metabolites have a wide variety of structures and are made by different enzymes working together to carry out a series of biochemical reactions.

We sought to understand how this novel pathway originated and diversified across 100 million years of plant evolution, said Last, MSU Barnett Rosenberg Professor of Biochemistry and Molecular Biology and Plant Biology and the studys senior author. This is our crystal ball, our view into evolution.

The crystal ball revealed that many of the enzymes that make acylsugars are promiscuous, meaning that they could use a variety of molecules as starting points for their chemical reactions. This could be the key as to how the plants make a variety of acylsugars.

The scientists also discovered that many of the enzymes that make acylsugars are encoded by genes that were originally copies of other genes and that have subsequently evolved new roles.

Deciphering these codes are important because tomatoes acylsugars are natural pesticides. Engineering plants to produce acylsugars could reduce pesticide use in crop production. Additionally, some of these mechanisms could help make chemicals that have pharmaceutical value, including ones that treat cancer and heart conditions.

Plants are master chemists, and were only just beginning to understand the metabolic pathways that they use to produce these amazing compounds, said Last, whos also an MSU AgBioResearch scientist. By understanding how the pathways evolved to produce these enzymes could lead to innovative ways to make valuable compounds on a large scale.

The MSU team of scientists contributing to this research included Gaurav Moghe, Bryan Leong, Steven Hurney and Daniel Jones. The paper is published in the current issue of the journal eLife.

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Tomatoes' 'Crystal Ball' Reveals Evolutionary Secrets - Laboratory Equipment

Anatomy & Cell Biology | IU School of Medicine

As one of the founding basic science departments at IU School of Medicine, the Department of Anatomy and Cell Biology has a long-standing and diverse history of anatomical science education and research dating back a hundred years. Today, modern anatomy as a scientific discipline encompasses cell and molecular biology, neuroscience, developmental biology, evolution, vertebrate paleontology, and anthropology, and this area of medicine leads the way in imaging technology and imaging-based research.

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Anatomy & Cell Biology | IU School of Medicine

Grey’s Anatomy: We Need to Talk About Jaggie – TV Guide

Now PlayingGrey's Anatomy 7 Worst Couples/Hookups, Ranked

Ever since Season 1 of Grey's Anatomy, fans have joked about the "incestuous" relationships among the show's doctors. Despite being close enough to their colleagues to consider them family, the doctors and residents at Grey Sloan (nee Seattle Grace) often found themselves falling into bed together. Like, really often.

But as the show prepares to enter its 14th season, the term "incest" may no longer be such a misnomer -- and some fans aren't having it.

We're talking, of course, about the budding romance between step-siblings Maggie Pierce (Kelly McCreary) and Jackson Avery (Jesse Williams), a pairing that seemed to emerge out of nowhere when none other than Jackson's ex-wife April (Sarah Drew) told Maggie it was clear Jackson had feelings for her in the Season 13 finale.

(via giphy)

Well, OK, maybe the spark didn't come out of nowhere. Maggie did turn to Jackson for support after her mother died in Season 13 -- even though he had kept Mrs. Pierce's condition a secret from Maggie while he was treating her. After that, they certainly seemed to grow closer at the hospital. But April's observation still came a little out of left field.

Grey's Anatomy Mega Buzz: Are Maggie and Jackson Actually a Thing?

After her failed romance with DeLuca (Giacomo Gianniotti) and unrequited crush on Riggs (Martin Henderson), it sounds like Maggie is just eenie-meenie-miney-mo'ing her way around the men at her workplace, without much success. Would it kill her (or any of the other doctors, for that matter) to maybe try an online dating service for once?

And a Maggie-Jackson romance provides yet another very convenient roadblock to keep Jackson and April -- a popular couple shipped by many fans who share a child, have their own hashtag (#Japril) and had an entire episode devoted to themselves last season -- apart for at least the better part of another year.

Also, and I believe I mentioned this earlier: the two are step-siblings. Maggie's father Richard (James Pickens Jr.) is married to Jackson's mother Catherine (Debbie Allen). What is this, Game of Thrones?

Whether Maggie and Jackson will actually take the plunge remains to be seen, but fans seem to be pretty divided about the potential pairing.

This week, Williams himself noted that fans seem to be "evenly divided" over the issue, but seemed to maybe indicate that he's not on board with it, retweeting a fan-made anti-Jaggie meme with the simple observation, "Very good."

Look, don't get me wrong: ever since Maggie's character was introduced at the end of Season 10, she's been one of the more interesting and likable characters on the show -- but has suffered nothing but heartache. The closest we've seen her come to having a relationship was her short-lived dalliances with DeLuca and her mostly offscreen stint with the radiologist Ethan. It would be great to see Maggie in a long-term, fulfilling relationship, the likes of which we've seen almost all of the other Grey's characters involved in. Not only is it about time for Maggie to have something good happen to her, giving her a significant other would also provide a wealth of potential drama for a character who longs for a partner -- despite having made her studies and career a priority for her whole life (and who we know has deemed herself incapable of sleeping next to other people).

But a Maggie-Jackson pairing seems like merely a plot device, an arbitrary pairing-off that makes Maggie little more than a pawn in the larger #Japril storyline. There's no denying that there is chemistry between Williams and McCreary; but up until this point it's seemed to be more of the brother/sister variety because, well, that's what they are. Plus, with so many fans already voicing their disdain for the romance before it's even officially happened, it will be a difficult task for the writers and actors to develop the two characters into a couple worth rooting for. And the alternative -- turning viewers against one or both of the mostly beloved characters -- is almost worse. It would be a better idea to put the idea of Jaggie to bed rather than in one.

Also, ew.

Grey's Anatomy kicks off Season 14 with a two-hour premiere Thursday, Sept. 28 at 8/7c on ABC.

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Grey's Anatomy: We Need to Talk About Jaggie - TV Guide

Grey’s Anatomy has "no plans" to bring back Callie in season 14 – DigitalSpy.com

Getty ImagesRon Batzdorff/ABC

Dr Teddy Altman might be returning to Grey's Anatomy in season 14, but don't expect to see Dr Callie Torres back.

Sara Ramirez left her role as Callie in season 12's finale to take "some welcome time off", but with her ex-love Arizona (Jessica Capshaw) losing her love interest Eliza, the door is open for a possible return for Callie.

But that's not happening anytime soon.

ABC

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Related: Grey's Anatomy season 14 everything you need to know

"There are no plans at the moment. We love her and we miss her, [but] there's been no discussion of it," executive producer Debbie Allen told TVLine of a possible return for Ramirez.

Since leaving the show, Ramirez has called out ABC for airing a joke mocking bisexual people on sitcom The Real O'Neals.

Ramirez, who identifies as bisexual, urged her followers on Twitter to sign a petition that accused the network of biphobia by sharing a link and writing that "WORDS MATTER".

ABCAdam Taylor

Earlier this year, Capshaw had spoken about the possible return of Arizona's ex-love to Grey Sloan Memorial. "I feel like nothing is impossible. There's a great chance she would come back for something," she explained.

Her co-star Giacomo Gianniotti has also been teasing that the new season is "funnier, sexier, lighter" after admitting that the show has been "dreary for a long time".

Grey's Anatomy returns to ABC in the US on September 28. Sky Living airs the show in the UK, with a return date to be announced.

Want up-to-the-minute entertainment news and features? Just hit 'Like' on our Digital Spy Facebook page and 'Follow' on our @digitalspy Twitter account and you're all set.

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Grey's Anatomy has "no plans" to bring back Callie in season 14 - DigitalSpy.com

‘Grey’s Anatomy’ EP Kills Hope of Sara Ramirez Returning in Season 14 … For Now – Moviefone

When Sara Ramirez said goodbye to "Grey's Anatomy" in Season 12, it sounded more like "see you later"; yet, so far, that "later" still hasn't come.

Debbie Allen, one of the ABC drama's executive producers, has made it clear that a Ramirez return as her character, Dr. Callie Torres, is not currently in the works. The EP told TVLine that "there are no plans at the moment" to bring back the fan favorite orthopedic surgeon.

"We love her and we miss her, [but] there's been no discussion of it," Allen said.

We also miss Callie, so we're focusing on the possible silver lining here: Allen said "at the moment," which leaves the door open for the future. Ramirez herself did the same when she left the show, saying that she was taking "some time off." The actress even indicated that she and producers would "definitely continue our conversations, making it seem very possible that Callie could someday do another stint at Grey Sloan Memorial Hospital.

If Callie does return at any point, many fans will be angling for her to rekindle her relationship with Dr. Arizona Robbins (Jessica Capshaw). Her former co-worker and love is going to be back on the market in Season 14 after the departure of Dr. Eliza Minnick (Marika Dominczyk). With that being the case, "Calzona" shippers have reason to hang onto at least some hope.

No, we won't see Ramirez when "Grey's Anatomy" Season 14 premieres on Sept. 25 at 8 p.m. ET/PT, but we will wait and see what the future holds.

[via: TVLine]

Some doctors at a hospital in Seattle -- including several who began their careers at the facility as interns -- try to balance life and work. Read More

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'Grey's Anatomy' EP Kills Hope of Sara Ramirez Returning in Season 14 ... For Now - Moviefone

‘Grey’s Anatomy’: Is Sara Ramirez Returning As Callie In Season 14? – Hollywood Life

OMG! Is another Greys Anatomy alum returning to the ABC series for its upcoming Season 14? First Kim Raver and now Sara Ramirez?! Find out here, as EP Debbie Allen just spilled the tea!

While we would love to report the opposite, currently, there are no plans at the moment forSara Ramirezto return as Callie in Greys Anatomys upcoming 14th season, executive producer Debbie Allen told our sister site, TVLine. Then, Debbie added, We love her and we miss her, so maybe theres hope for the future? But like we said, dont hold your breath for a Season 14 return. Theres been no discussion of it at this time, Debbie concluded.

We have to admit, now would have been the perfect time for Sara to return to Greys Anatomy. Especially if she and Arizona (Jessica Capshaw) were ever going to consider getting back together.Marika Dominczyk, who played Arizonasmost recent love interest, Eliza Minnick will not be back for Season 14, TVLine also reports. This means, Arizona will be single and ready to mingle when Season 14 premieres on Sept. 28. Its unclear if Callies still dating Penny, but who ever really cared about that relationship anyway?

As youll recall, Eliza was fired in the Season 13 finale. In her final scene, she told Arizona about her termination. We never saw them break up, butthe couples split is going to be addressed in the two-hour premiere, Debbie confirmed. Its very interesting how we address it.

As for Sara Ramirez, Callie made her final appearance in the Season 12 finale of Greys Anatomy, when she relocated to New York to live with her girlfriend, Penny. At the time, the actress said,Im deeply grateful to have spent the last 10 years with my family atGreys Anatomyand ABC, but for now, Im taking some welcome time off. [Series creator] Shonda [Rhimes has] been so incredible to work for, and we will definitely continue our conversations.

HollywoodLifers, how do YOU feel? Should Sara Ramirez return as Callie? Tell us below!

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'Grey's Anatomy': Is Sara Ramirez Returning As Callie In Season 14? - Hollywood Life

The Anatomy of an Upset: How South can beat Ole Miss – WKRG

MOBILE, Ala. As far as this Saturday, we know Ole Miss is a very good opponent, said South Alabama coach Joey Jones. Were ready to go to a SEC school, and a SEC stadium to play a ballgame. Its exciting for our players.

The anatomy of an upset. It all starts with a mindset. A belief anything is possible.

Theyre not intimidated by the venue. Weve been to Tennessee, weve been to South Carolina and Mississippi State, said Jones. I think they have a little chip on their shoulder. They want to show people what they can do.

To pull off an upset, you have to be prepared. The Jags have been in fall camp for nearly a month.

They know toughness is going to win. They know toughness is going to win on the road. Toughness is going to win those close ballgames, said Jones.

And they have more depth than ever.

A crucial component if you want to beat a SEC foe.

If you look at it over the years, most of those games we sort of wore down at the end of the game. They would kind of get us late in the fourth quarter because were just tired. So having those fresh legs in their will certainly make a difference, said Jones.

Depth, preparation and a belief in yourself and your unit, the necessary ingredients to pull off an upset.

Now its time to put it all to the test.

Were going to bring this program to the next level. Thats our goal this year, said Jones.

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The Anatomy of an Upset: How South can beat Ole Miss - WKRG

Album Premiere: The Anatomy of Frank Find Warmth in the Cold on ‘South America’ – Atwood Magazine (blog)

Recommended If You Like: Iron & Wine, Will Graefe, Mappe Of

What an amazing feeling it is, for a whisper to feel like a roar: For a light guitar to feel like the heaviest thing in the world. Such is the experience of The Anatomy of Franks new album,South America, a breathtaking and intimate exploration of life, love, travel and being. Deceptively simple and utterly human, this record is not to be missed.

Atwood Magazine is proud to be premiering South America, The Anatomy of Franks powerful third album (independently out 8/31/2017). With the goal of recording an album on every continent (and being the first band to do so), The Anatomy of Frank are not only a talented folk/rock indie act, but also a band with a true mission. Consisting of Kyle Woolard (guitar, vocals), Jimmy Bullis (keyboards) and Max Bollinger (drums), the Charlottesville, Virginia-based trio ascribe to no genre in particular; instead, they often look to themes like personal growth, coping with loss and change, etc, to define their identity. Recorded, as its name suggests, on the South American continent, South Americais the second record and continent to be checked off The Anatomy of Franks list the first being 2015sNorth America.

South America The Anatomy of Frank

Yet you do not need to be familiar with The Anatomy of Franks previous work in order to enjoy their latest output: Sporting an array of marvelous harmonies and incredibly haunting imagery,South Americashoots high and nails the landing. From the slow rise of album openerEcuador (A New Year) to its shuddering close, Viteri and everything in-between, The Anatomy of Frank continually immerse their audience in warm acoustic and electric journeys that capture the heart.

I never felt worse than when I finally let go of these songs, shares guitar and vocalist Kyle Woolard. It was like postpartum depression theyd lived within me for so long, and suddenly they were no longer when I record this one day songs. I struggled for several months before I was able to get back on track. They chronicle a lot of my internal struggles and life experiences throughout the past decade.

Anatomy of Frank 2017

Recorded with Stephen Cope in a private farmhouse in the Ecuadorian mountains in 5 short weeks, South Americacombines hope and strife, passion with vision. Songs like the personal ballad La Llorena leave a lasting impression upon first listen, and though The Anatomy of Franks subject matter is deep and difficult to digest, South America is immediately accessible and easy to fall in love with. In a sense, The Anatomy of Frank have taken some of the hardest, worst aspects of our world, and created something beautiful with them: Theyve found warmth in the cold.

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Album Premiere: The Anatomy of Frank Find Warmth in the Cold on 'South America' - Atwood Magazine (blog)