Monthly Archives: July 2017

Cell Biology

Is sense of smell linked to being fatter or thinner? – CBS News

Would you be willing to give up the smell of fresh-baked chocolate chip cookies or a pizza right out of the oven if it meant slimming down?

A new study showed that mice that lost their sense of smell didn't gain weight even when they ate the same high-fat diet as mice that could smell and did gain weight.

The mice that retained their sense of smell packed on twice their normal weightwhile the smell-deficient mice didn't gain at all, scientists from the University of California, Berkeley, reported in the journal Cell Metabolism.

A group of mice whose olfactory neurons had been genetically altered to take away their sense of smell were also compared with another group of mice whose sense of smell had been enhanced. The "super-smellers" gained even more weight.

Two mice on the same high-fat diet are shown in the photo. The mouse on the top grew plump but the mouse on the bottom, whose sense of smell was blocked by UC Berkeley researchers, stayed a normal weight.

Andrew Dillin and Celine Riera, UC Berkeley

"This paper is one of the first studies that really shows if we manipulate olfactory inputs, we can actually alter how the brain perceives energy balance, and how the brain regulates energy balance," said study author Cline Riera.

The findings raise questions about whether or not the same would hold true for humans, Riera, a former UC Berkeley postdoctoral fellow now an assistant professor at Cedars-Sinai Medical Center in Los Angeles, told CBS News.

"The cool thing about olfactory nerves is that they are totally unique. They're not in brain, they're in the nose. Maybe in future, we can non-invasively block them in humans. Maybe if you can remove olfaction in the patients for several months, it may help them lose weight," she said.

In an article in Berkeley News, senior study author Andrew Dillin said, "Sensory systems play a role in metabolism. Weight gain isn't purely a measure of the calories taken in; it's also related to how those calories are perceived."

The researchers hope future work in this area could someday benefit patients who are morbidly obese or overweight people with health problems like diabetes.

Dillin, a professor of molecular and cell biology and Howard Hughes Medical Institute investigator, said that if the discovery proves true in humans as well as mice, it could offer new treatment options for obese patients thinking about stomach stapling or bariatric surgery. "For that small group of people, you could wipe out their smell for maybe six months and then let the olfactory neurons grow back, after they've got their metabolic program rewired," he suggested.

Those with food addictions, such as binge-eating disorders, might be helped, too.

Riera said, "We hope to eventually find a way to do that in humans as well, and help them control their addictive behaviors and switch their metabolism to fat burning instead of fat storage."

2017 CBS Interactive Inc. All Rights Reserved.

Read this article:
Is sense of smell linked to being fatter or thinner? - CBS News

Cell Biology

‘Liquid scaffolding’: Watery droplets form structures inside cells – Princeton University

A research team led by Princeton engineers has revealed in remarkable new detail how liquid droplets can develop structure amidst the soup of material found inside a living cell. These droplets, known as membraneless organelles, play critical roles in cellular function and diseases.

The team, a mix of biologists and materials scientists, has shown that surprisingly low concentrations of proteins can readily condense into a droplet that has internal structure, yet is very dilute, consisting mostly of empty, watery space. This liquid scaffolding lets molecules only of certain sizes easily diffuse in and out of the structure, enabling them to perform their vital tasks.

The new insights into the molecular organization inside membraneless organelles will help clarify their contributions to health and when that organization breaks down to certain diseases.

In this study, we have measured important aspects of the protein-to-protein interactions that drive the form and function of a membraneless organelle, said Ming-Tzo Wei, a postdoctoral research associate in the Department of Chemical and Biological Engineering and lead author of the study published June 26 in the journal Nature Chemistry.

Were really starting to understand the molecular-level organization within this membraneless class of cellular structures, saidClifford Brangwynne, an assistant professor ofchemical and biological engineering, senior author of the paper and principal investigator of the Soft Living Matter Group.

At left: Membraneless organelles, called P granules, are shown in green around a cell's nucleus in a flatworm embryo. Middle: A zoom-in of the liquid-like organelles. At right: An artist's impression of a tighter zoom into the P granule, revealing its structure that it is permeable to molecules only of certain sizes, shown in red.

Image courtesy of the researchers

The team collaborated with Rohit Pappu, a biomedical engineer at Washington University in St. Louis, and also includedRodney Priestley, associate professor of chemical and biological engineering, andCraig Arnold, director of thePrinceton Institute for the Science and Technology of Materials.

The researchers focused on a protein type, LAF-1, that joins with other proteins and RNA to form a globular, membraneless organelle called a P granule. In a popularly studied roundworm,Caenorhabditis elegans, the P granules keep the worms sex cells in a prepared state for reproduction.

A set of experiments sought to determine the concentration of LAF-1 inside of a P granule versus the levels of the protein otherwise floating freely within the cell. Knowing the difference would tell the researchers what concentration of the protein is needed to form the structure. A novel technique, called ultrafast-scanning fluorescence correlation spectroscopy, proved critical to the task.

Developed in collaboration with paper co-author Arnold, who also is a professor of mechanical and aerospace engineering, the technique uses a special lens to reduce uncertainty about the size of a volume being scanned by a microscope. As a result, the concentration of proteins fitted with fluorescent tags can be accurately determined in a given space, for instance within a P granule.

Wei took a series of such measurements, along with co-first author Shana Elbaum-Garfinkle, also a postdoctoral research associate in the Department of Chemical and Biological Engineering. In addition, the researchers tracked the motions of molecules in the P granule and observed how interactions with RNA reduced the protein concentration, in effect lowering the granules fluid consistency, or viscosity.

For further insight, the researchers turned to the science of polymers, which are substances composed of many similar, smaller units, like those found in consumer plastic products. LAF-1 is a disordered protein, and can be thought of as a flexible polymer chain. The polymeric nature of LAF-1 allows it to form a scaffold-like network within the droplet. However, unlike with plastics, the teams results indicated that the mesh size, or average size of the gaps between units, is relatively large, three to eight nanometers (billionths of a meter). Molecules larger than this span cannot move throughout the droplet. This result places limits on the kinds of material that the membraneless organelle can interact with inside of a cell, shedding light on its function.

The findings were further validated by a series of computer simulations run by computational biophysicist and co-first author Alex Holehouse, a graduate student working closely with his adviser Pappu of Washington University in St. Louis.

We were able to basically swim inside the organelles to determine how much room is actually available," Pappu said in a news story published by Washington University. "While we expected to see a crowded swimming pool, we found one with plenty of room, and water. Were starting to realize that these droplets are not all going to be the same.

Pappu added that the implications for the work are broad. It is essential to be able to understand how one can regulate the functions of these droplets, Pappu said. If we succeed, the impact could be transformative: its not just cancer, its neurodegeneration, about developmental disorders, and even the fundamentals of cell biology.

The advance required the melding of multiple perspectives and expertise, Brangwynne said.

This study represents a unique collaboration between soft matter and polymer physics, mechanical engineering, computational physics and biology, said Brangwynne. Working together in this way has given us all a real sense of triumph in having helped move science forward.

Additional authors on the paper include Carlos Chih-Hsiung Chen, a research specialist in the Department of Chemical and Biological Engineering, and Marina Feric, formerly of Princeton and now a postdoctoral fellow at the National Institutes of Health. The work was supported by the Princeton Center for Complex Materials, the National Science Foundation, the National Institutes of Health and the Eric and Wendy Schmidt Transformative Technology Fund.

More:
'Liquid scaffolding': Watery droplets form structures inside cells - Princeton University

Genetics

Molecular Genetics – Genetics Conferences

Sessions/Tracks

Track 1:Molecular Biology

Molecular biologyis the study of molecular underpinnings of the processes ofreplication,transcription,translation, and cell function. Molecular biology concerns themolecularbasis ofbiologicalactivity between thebiomoleculesin various systems of acell,gene sequencingand this includes the interactions between theDNA,RNAand proteinsand theirbiosynthesis. Inmolecular biologythe researchers use specific techniques native to molecular biology, increasingly combine these techniques and ideas from thegeneticsandbiochemistry.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

2nd World Congress onHuman Genetics&Genetic Disorders, November 02-03, 2017 Toronto, Canada; 9th International Conference onGenomicsandPharmacogenomics, June 15-16, 2017 London, Uk; 6th International Conference and Exhibition onCellandGene Therapy, Mar 27-28, 2017 Madrid, Spain; Gordon Research Conference,Viruses&Cells, 14 - 19 May 2017, Lucca, Italy;Human Genome Meeting(HGM 2017), February 5-7 2017, Barcelona, Spain; Embl Conference:Mammalian GeneticsAndGenomics:From Molecular Mechanisms To Translational Applications, Heidelberg, Germany, October 24, 2017;GeneticandPhysiological Impacts of Transposable Elements, October 10, 2017, Heidelberg, Germany.

American Society for Cell Biology;The Society for Molecular Biology & Evolution;American Society for Biochemistry and Molecular Biology;The Nigerian Society of Biochemistry and Molecular Biology;Molecular Biology Association Search Form - CGAP.

Track 2:Gene Therapy and Genetic Engineering

Thegenetic engineeringis also called asgenetic modification. It is the direct manipulation of an organism'sofgenomeby usingbiotechnology. It is a set of technologies used to change the genetic makeup of the cell and including the transfer of genes across species boundaries to produce improved novelorganisms. Genesmay be removed, or "knocked out", using anuclease.Gene is targetinga different technique that useshomologousrecombinationto change anendogenous gene, and this can be used to delete a gene, removeexons, add a gene, or to introducegenetic mutations. There is an dna replacement therapy, Genetic engineering does not normally include traditional animal and plant breeding, gene sequencing, in vitro fertilization, induction of polyploidy,mutagenesisand cell fusion techniques that do not use recombinant nucleic acids or a genetically modified organism in the process,diseases treated with gene therapywas initially meant to introduce genes straight into human cells, focusing on diseases caused by single-gene defects, such as cystic fibrosis, hemophilia, muscular dystrophy and sickle cell anemia

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

8thWorld Congress onMolecular Pathology, June 26-27, 2017 San Diego, USA; 11thInternational Conference onSurgical Pathology& Practice, March 27-28, 2017, MADRID, SPAIN; 13th EuropeanPathologyCongress, Aug 02-03, 2017, MILAN, ITALY; 28th Annual Meeting, Austrian Society ForHuman GeneticsAnd The Swiss Society OfMedical GeneticsCombined Meeting 2017 march 29, 2017 - March 31, 2017, bochum , Germany.

Association for Clinical Genetic Science;Genetics Society of America | GSA;Association of Genetic Technologists;Molecular Genetics - Human Genetics Society of Australasia;Genetic Engineering - Ecological Farming Association.

Track 3:Cell & Gene Therapy

Cell therapy is also calledcellular therapyorCyto therapy, in which cellular material is injected into patient this generally means intact, living cells. The first category iscell therapyin mainstream medicine. This is the subject of intense research and the basis of potential therapeutic benefit. Such research can be controversial when it involves human embryonic material. The second category is in alternative medicine, and perpetuates the practice of injecting animal materials in an attempt to cure disease.Gene therapyis the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy is a way to fix agenetic problemat its source. The polymers are either translated into proteins, interfere with targetgene expression, or possibly correct genetic mutations. The most common form uses DNA that encodes a functional,therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a "vector", which carries the molecule inside cells. Vectors used in gene therapy, the vector incorporates genes intochromosomes. The expressed nucleases then knock out and replace genes in the chromosome. The Center forCell and Gene Therapyconducts research into numerous diseases, including but not limited to PediatricCancer, HIV gliomaandCardiovascular disease.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

2nd World Congress onHuman Genetics&Genetic Disorders, November 02-03, 2017 Toronto, 27 Canada ; 7th International Conference onPlant Genomics, July 03-05, 2017, Bangkok, Thailand ; American Society ofGeneandCell Therapy(ASGCT) 20th Annual Meeting, 10 - 13 May 2017, Washington, DC;Genomic Medicine for Clinicians(course), January 25-27, 2017, Hinxton , Cambridge, UK; Embo Conference:ChromatinandEpigenetics, Heidelberg, Germany, May 3, 2017; 14th International Symposium on Variants in theGenomeSantiago de Compostela, Galicia, Spain, June 5 - 8, 2017;

Genetics and Molecular Medicine - American Medical Association;Genetics Society of America / Gsa;British Society for Genetic Medicine;British Society for Gene and Cell Therapy; Australasian Gene Therapy Society.

Track 4:Cell Cancer Immunotherapy

Immunologydeals with the biological and biochemical basis for the body's defense against germs such as bacteria, virus and mycosis (fungal infections) as well as foreign agents such asbiological toxinsand environmental pollutants, and failures and malfunctions of these defense mechanisms. Cancer immunotherapy is the use of the immune system to treat cancer. Immunotherapies can be categorized as active, passive or hybrid (active and passive). Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. The immune system normally uses them to fight pathogens. A type of biological therapy that uses substances to stimulate or suppress the immune system to help the body fight cancer, infection, and other diseases. Some types of immunotherapy only target certain cells of the immune system. Others affect the immune system in a general way. Types of immunotherapy include cytokines, vaccines, bacillus Calmette-Guerin (BCG), and some monoclonal antibodies.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

9thAnnual Meeting onImmunologyandImmunologist, July 03-05, 2017 Kuala Lumpur, Malaysia; 8th MolecularImmunology&ImmunogeneticsCongress, March 20-21, 2017 Rome, Italy; 8th EuropeanImmunologyConference, June 29-July 01, 2017 Madrid, Spain; July 03-05, 2017; B Cells and T Follicular Helper Cells Controlling Long-Lived Immunity (D2), April 2017, 2327, Whistler, British Columbia, Canada; Mononuclear Phagocytes in Health,Immune Defense and Disease, 304 May, Austin, Texas, USA;Modeling Viral Infections and ImmunityMAY 2017, 14, Estes Park, Colorado, USA; IntegratingMetabolism and Immunity(E4)292 June, Dublin, Ireland.

The American Association of Immunologists;Clinical Immunology Society ; Indian Immunology Society;IUIS - International Union of Immunological Societies;American Society for Histocompatibility and Immunogenetics.

Track 5:Clinical Genetics

Clinical geneticsis the practice of clinical medicine with particular attention tothe hereditary disorders. Referrals are made togenetics clinicsfor the variety of reasons, includingbirth defects,developmental delay,autism,epilepsy, and many others. In the United States, physicians who practice clinical genetics are accredited by theAmerican Board of Medical Genetics and Genomics(ABMGG).In order to become a board-certified practitioner of a Clinical Genetics, a physician must complete minimum of 24 months of his training in a program accredited by the ABMGG. Individual seeking acceptance intoclinical geneticstraining programs and should hold an M.D. or D.O. degree (or their equivalent)and he/she have completed a minimum of 24 months of their training in ACGME-accredited residency program internal medicine, pediatrics and gynecology or other medical specialty.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

Belgian Society OfHuman GeneticsMeeting 2017 february 17, 2017, Belgium; American College Of Medical Genetics 2017 AnnualClinical GeneticsMeeting march 21-25 2017, phoenix , United States; German Society Of Human Genetics 28th Annual Meeting, Austrian Society ForHuman GeneticsAnd The Swiss Society OfMedical GeneticsCombined Meeting 2017 march 29, 2017 - March 31, 2017, bochum , Germany; Spanish Society OfHuman GeneticsCongress 2017april 25, 2017 - April 28, 2017 madrid , Spain;

Clinical Genetics Associates;Clinical Genetics Society(CGS);The genetic associate;International Conference on Clinical and Medical Genetics;Association for Clinical Genetic Science;The American Society of Human Genetics.

Track 6:Pharmacogenetics

Pharmacogeneticsis the study of inherited genetic differences in drug metabolic pathways which can affect individual responses towards the drugs, both in their terms of therapeutic effect as well as adverse effects. In oncology, Pharmacogenetics historically is the study ofgerm line mutations(e.g., single-nucleotide polymorphisms affecting genes coding forliver enzymesresponsible for drug deposition and pharmacokinetics), whereaspharmacogenomicsrefers tosomatic mutationsin tumoral DNA leading to alteration in drug response.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

Spanish Society OfHuman GeneticsCongress 2017april 25, 2017 - April 28, 2017, madrid , Spain; 8th World Congress onPharmacology, August 07-09, 2017 Paris, France; World Congress onBio therapeutics, May 22-23, 2017, Mexico City, Mexico; 8th World Congress OnPharmacologyAndToxicology, July 24-26, 2017, Melbourne, Australia; German Society Of Human Genetics 28th Annual Meeting, Austrian Society ForHuman GeneticsAnd The Swiss Society OfMedical GeneticsCombined Meeting 2017march 29, 2017 - March 31, 2017 bochum , Germany.

Pharmacogenomics - American Medical Association;Associate Principal Scientist Clinical Pharmacogenetics;European Society of Pharmacogenomics and Personalised Therapy;Genome-wide association studies in pharmacogenomics.

Track 7:Molecular Genetic Pathology

Molecular genetic pathologyis an emerging discipline withinthe pathologywhich is focused in the study and diagnosis of disease through examination of molecules within the organs, tissues or body fluids. A key consideration is more accurate diagnosis is possible when the diagnosis is based on both morphologic changes in tissuestraditional anatomic pathologyand onmolecular testing. Molecular Genetic Pathology is commonly used in diagnosis of cancer and infectious diseases. Integration of "molecular pathology" and "epidemiology" led tointerdisciplinaryfield, termed "molecular pathological epidemiology" (MPE),which representsintegrative molecular biologicand population health science.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

8th World Congress OnMolecular Pathology, June 26-27, 2017 San Diego, USA; 11th International Conference OnSurgical Pathology& Practice, March 27-28, 2017, Madrid, Spain; 13th EuropeanPathologyCongress, Aug 02-03, 2017, Milan, Italy; Embl Conference:Mammalian GeneticsAndGenomics, Heidelberg, Germany, October 24, 2017; Embo|Embl Symposium: TheMobile Genome: Genetic And Physiological Impacts Of Transposable Elements, Heidelberg, Germany, October 10, 2017.

Clinical Pathology Associates Molecular Pathology; Association mapping Wikipedia;Association for Molecular Pathology(AMP);Molecular Pathology - Association of Clinical Pathologists;SELECTBIO - Molecular Pathology Association of India.

Track 8:Gene Mapping

Genomemappingis to place a collection of molecular markers onto their respective positions ongenome.Molecular markerscome in all forms. Genes can be viewed as one special type of genetic markers in construction ofgenome maps, and the map is mapped the same way as any other markers. The quality ofgenetic mapsis largely dependent upon the two factors, the number of genetic markers on the map and the size of themapping population. The two factors are interlinked, and as larger mapping population could increase the "resolution" of the maps and prevent the map being "saturated". Researchers begin a genetic map by collecting samples of blood or tissue from family members that carry a prominent disease or trait and family members that don't. Scientists then isolate DNA from the samples and closely examine it, looking for unique patterns in the DNA of the family members who do carry the disease that the DNA of those who don't carry the disease don't have. These unique molecular patterns in the DNA are referred to as polymorphisms, or markers.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

3rd WorldBio Summit&Expo, Abu Dhabi, UAE, June 19-21, 2017; 9th International Conference onGenomicsandPharmacogenomicsJune 15-16, 2017 London, Uk; Keystone Symposium: Mononuclear Phagocytes in Health,Immune DefenseandDisease, 304 May 2017, Austin, Texas, USA;Molecular Neurodegeneration(course) Hinxton, Cambridge, UK, January 9-14, 2017;

Association for Clinical Genetic Science;Genome-wide association study Wikipedia;Gene mapping by linkage and association analysis NCBI;Gene mapping by linkage and association analysis | Springer Link.

Track 9:ComputationalGenomics

Computational genomics refers to the use of computational and statistical analysis to decipherbiologyfromgenome sequencesand related data, including DNA and RNA sequence as well as other "post-genomic" data. This computational genomics is also known asComputational Genetics. These, in combination with computational and statistical approaches to understanding the function of the genes and statistical association analysis, this field is also often referred to as Computational and Statistical Genetics/genomics. As such, computational genomics may be regarded as a subset of bioinformatics and computational biology, but with a focus on using whole genomes rather than individual genes to understand the principles of how the DNA of a species controls its biology at the molecular level and beyond. With the current abundance of massive biological datasets, computational studies have become one of the most important means to biological discovery.The field is defined and includes foundations in thecomputer sciences,applied mathematics, animation, biochemistry, chemistry, biophysics,molecular genetics,neuroscienceandvisualization. Computational biology is different from biological computation, which is a subfield of computer engineering using bioengineering and biology to build computers, but is similar tobioinformatics.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

Modeling Viral Infections and Immunity,10. MAY 2017, 14, Estes Park, Colorado, USA;Integrating Metabolism and Immunity(E4)292 June, Dublin, Ireland; EMBL Conference:Mammalian GeneticsandGenomics, Heidelberg, Germany, October 24, 2017; EMBO|EMBL Symposium: The Mobile Genome:GeneticandPhysiological Impacts of Transposable Elements, Heidelberg, Germany, October 10, 2017;

American Association of Bio analysts - Molecular/Genetic Testing;ISCB - International Society for Computational Biology;International Society for Computational Biology Wikipedia;Bioinformatics societies OMICtools;Towards an Australian Bioinformatics Society.

Track 10:Molecular Biotechnology

Molecular Biotechnologyis the use of living systems and organisms to develop or to make products, or "any technological application that uses the biological systems, living organisms or derivatives, to make or modify products or processes for specific use. Molecular biotechnology results from the convergence of many areas of research, such as molecular biology, microbiology, biochemistry, immunology, genetics and cell biology. It is an exciting field fueled by the ability to transfer genetic information between organisms with the goal of understanding important biological processes or creating a useful product. The completion of the human genome project has opened a myriad of opportunities to create new medicines and treatments, as well as approaches to improve existing medicines. Molecular biotechnology is a rapidly changing and dynamic field. As the pace of advances accelerates, its influence will increase. The importance and impact of molecular biotechnology is being felt across the nation. Depending on the tools and applications, it often overlaps with the related fields of bioengineering,biomedical engineering, bio manufacturing andmolecular engineering.Biotechnologyalso writes on the pure biological sciences animalcell culture, biochemistry,cell biology, embryology, genetics, microbiology, andmolecular biology.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

8th EuropeanImmunologyConference, June 29-July 01, 2017 Madrid, Spain; World Congress onBio therapeutics, May 22-23, 2017, Mexico City, Mexico;Human Genome Meeting(HGM 2017), February 5-7 2017, Barcelona, Spain;Integrating MetabolismandImmunity (E4), 292 June, Dublin, Ireland.

Biotech Associations - Stanford University;Indian Society of Genetics, Biotechnology Research & Development;Genetics and Molecular Medicine - American Medical Association;Genetics Society of America | GSA, British Society for Genetic Medicine;Heritability in the Era of Molecular Genetics - Association for Psychological science.

Track 11:Genetic Transformation

Genetic Transformationis the genetic alteration of cell resulting from the direct uptake and incorporation ofexogenous genetic materialfrom its surroundings through thecell membrane. Transformation is one of three processes for horizontal gene transfer, in which exogenous genetic material passes from bacterium to another, the other two being conjugation transfer of genetic material between two bacterial cells in direct contact andTransductioninjection offoreign DNAby a bacteriophage virus into thehost bacterium. And about 80 species of bacteria were known to be capable of transformation, in 2014, about evenly divided betweenGram-positiveandGram-negative Transformation" may also be used to describe the insertion of new genetic material into non-bacterial cells, including animal and plant cells.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

13th EuropeanPathologyCongress, Milan, Italy; Embl Conference:Mammalian GeneticsAndGenomics, Heidelberg, Germany, October 24, 2017; Embo|Embl Symposium: TheMobile Genome: Genetic And Physiological Impacts Of Transposable Elements, Heidelberg, Germany, October 10, 2017; 2nd World Congress onHuman Genetics&Genetic Disorders, November 02-03, 2017 Toronto, Canada; 9th International Conference onGenomicsandPharmacogenomics, June 15-16, 2017 London, Uk;

American Society of Gene & Cell Therapy: ASGCT;Gene Therapy Societies and Patient Organizations - Gene Therapy Net;European Society of Gene and Cell Therapy (ESGCT);British Society for Gene and Cell Therapy;Gene Therapy - American Medical Association.

Track 12:Genetic Screening

Genetic screenis an experimental technique used to identify and select the individuals who possess a phenotype of interest inmutagenized population. A genetic screen is a type ofphenotypic screen. Genetic screen can provide important information on gene function as well as the molecular events that underlie a biological process or pathway. While thegenome projectshave identified an extensive inventory of genes in many different organisms, genetic screens can provide valuable insight as to how thosegenes function.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

13th EuropeanPathologyCongress, Aug 02-03, 2017, Milan, Italy; 2nd World Congress onHuman Genetics&Genetic Disorders, November 02-03, 2017 Toronto, 27 Canada; 7th International Conference onPlant Genomics, July 03-05, 2017, Bangkok, Thailand; Embl Conference:Mammalian GeneticsAndGenomics, Heidelberg, Germany, October 24, 2017; Embo|Embl Symposium: TheMobile Genome: Genetic And Physiological Impacts Of Transposable Elements, Heidelberg, Germany, October 10, 2017, 10 - 13 May 2017, American Society ofGeneandCell Therapy(ASGCT) 20th Annual Meeting, Washington, DC;

Association for Clinical Genetic Science; Association for Molecular Pathology (AMP);Mapping heritability and molecular genetic associations with cortical;Genetics and Molecular Medicine - American Medical Association.

Track 13:Regulation of Gene Expression

Regulation of Gene expressionincludes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA), and is informally termed gene regulation. Sophisticated programs of gene expression are widely observed in biology, Virtually any step of gene expression can be modulated, fromtranscriptional initiation,RNA processing, and post-translational modificationof a protein. Often, one gene regulator controls another in a gene regulatory network. Any step of gene expression may be modulated, from theDNA-RNA transcriptionstep to post-translational modification of a protein.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

7th International Conference onPlant Genomics, July 03-05, 2017, Bangkok, Thailand; EMBO|EMBL Symposium: The Mobile Genome:GeneticandPhysiological Impacts of Transposable Elements, Heidelberg, Germany, October 10, 2017; 10. MAY 2017, 14, Estes Park, Colorado, USA,Modeling Viral Infections and Immunity; 292 June, Dublin, Ireland,Integrating Metabolism and Immunity(E4); MAY 2017, 14, Estes Park, Colorado, USA,Modeling Viral InfectionsandImmunity; 8th EuropeanImmunologyConference, June 29-July 01, 2017 Madrid, Spain; 9th International Conference onGenomicsandPharmacogenomics, June 15-16, 2017 London, Uk;

Gene Therapy Societies and Patient Organizations - Gene Therapy Net;European Society of Gene and Cell Therapy (ESGCT);British Society for Gene and Cell Therapy;Gene Therapy - American Medical Association

Track 14: Cancer Gene Therapy

Cancer is an abnormal growth of cells the proximate cause of which is an imbalance in cell proliferation and death breaking-through the normal physiological checks and balances system and the ultimate cause of which are one or more of a variety of gene alterations. These alterations can be structural, e.g., mutations, insertions, deletions, amplifications, fusions and translocations, or functional (heritable changes without changes in nucleotide sequence). No single genomic change is found in all cancers and multiple changes (heterogeneity) are commonly found in each cancer generally independent of histology. In healthy adults, the immune system may recognize and kill the cancer cells or allow non-detrimental host-cancer equilibrium; unfortunately, cancer cells can sometimes escape the immune system resulting in expansion and spread of these cancer cells leading to serious life threatening disease. Approaches to cancer gene therapy include three main strategies: the insertion of a normal gene into cancer cells to replace a mutated (or otherwise altered) gene, genetic modification to silence a mutated gene, and genetic approaches to directly kill the cancer cells. Pathway C represents immunotherapy using altered immune cells. Another unique immunotherapy strategy facilitated by gene therapy is to directly alter the patient's immune system in order to sensitize it to the cancer cells. One approach uses mononuclear circulating blood cells or bone marrow gathered from the patient.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

8th EuropeanImmunologyConference, June 29-July 01, 2017 Madrid, Spain; World Congress onBio therapeutics, May 22-23, 2017, Mexico City, Mexico;Human Genome Meeting(HGM 2017), February 5-7 2017, Barcelona, Spain;Integrating MetabolismandImmunity (E4), 292 June, Dublin, Ireland.

Biotech Associations - Stanford University;Indian Society of Genetics, Biotechnology Research & Development;Genetics and Molecular Medicine - American Medical Association;Genetics Society of America | GSA, British Society for Genetic Medicine;Heritability in the Era of Molecular Genetics - Association for Psychological science.

Track 15:Genetic Transplantation

Transplantation genetics is the field of biology and medicine relating to the genes that govern the acceptance or rejection of a transplant. The most important genes deciding the fate of a transplanted cell, tissue, or organ belong to what is termed the MHC (the major histocompatibility complex). Genetic Transplantation is the moving of an organ from one body to another or from a donor site to another location on the person's own body, to replace the recipient's damaged or absent organ. Organs and/or tissues that aretransplantedwithin the same person's body are calledauto grafts. Transplants that are recently performed between two subjects of the same species are calledallografts. Allografts can either be from a living or cadaveric source Organs that can be transplanted are the heart, kidneys, liver, lungs, pancreas, intestine, and thymus. The kidneys are the most commonlytransplanted organs, followed by the liver and then the heart. The main function of the MHC antigens is peptide presentation to the immune system to help distinguish self from non-self. These antigens are called HLA (human leukocyte antigens). They consists of three regions: class I (HLA-A,B,Cw), class II (HLA-DR,DQ,DP) and class III (no HLA genes)

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

8th World Congress onPharmacology, August 07-09, 2017 Paris, France; International Conference onClinicalandMolecular Genetics, Las Vegas, USA, April 24-26, 2017; Aug 02-03, 2017, 13th EuropeanPathologyCongress, Milan, Italy; Embl Conference:Mammalian GeneticsAndGenomics, Heidelberg, Germany, October 24, 2017; 7th International Conference onPlant Genomics, July 03-05, 2017, Bangkok, Thailand.

American society of Transplantation;American Society of Transplant Surgeons: ASTS; Patient associations. Donation and transplantation;American Society of Gene & Cell Therapy ASGCT;Gene Therapy Societies and Patient Organizations - Gene Therapy Net.

Track 16:Cytogenetics

Cytogeneticsis a branch ofgeneticsthat is concerned withstudy of the structure and function of the cell, especially thechromosomes. It includes routine analysis of G-banded chromosomes, othercytogenetic banding techniques, as well as molecular Cytogenetics such as fluorescent in suitable hybridization FISH and comparativegenomic hybridization.

RelatedMolecular Biology Conferences| Genetics Conferences|Gene Therapy Conferences|Biotechnology Conferences| Immune Cell Therapy Conferences

9thAnnual Meeting onImmunologyandImmunologist, July 03-05, 2017 Kuala Lumpur, Malaysia; 8th MolecularImmunology&ImmunogeneticsCongress, March 20-21, 2017 Rome, Italy; 8th EuropeanImmunologyConference, June 29-July 01, 2017 Madrid, Spain; July 03-05, 2017; B Cells and T Follicular Helper Cells Controlling Long-Lived Immunity (D2), April 2017, 2327, Whistler, British Columbia, Canada.

European Cytogeneticists Association;Association of Genetic Technologists;Association for Clinical Genetic Science;Cytogenetics - Human Genetics Society of Australasia;European Cytogeneticists Association

Molecular Biology 2016

Molecular Biology 2016 Report

2ndWorld Bio Summit & Molecular Biology Expowas organized during October 10-12, 2016 at Dubai, UAE. The conference was marked with the attendance ofEditorial Board Members of supporting journals, Scientists, young and brilliant researchers, business delegates and talented student communities representing more than 25 countries, who made this conference fruitful and productive.

This conference was based on the theme Recent advances in Bio Science which included the following scientific tracks:

Molecular Biology

Microbiology

Analytical Molecular Biology

Bioinformatics

Biochemistry and Molecular Biology

Molecular Biology and Biotechnology

Cancer Molecular Biology

Computational Biology

Molecular Biology of the Cell

Molecular biology of the cardiovascular system

Molecular Biology in Cellular Pathology

Molecular Biology of Diabetes

Molecular Biology and Genetic Engineering

Enzymology and Molecular Biology

Molecular Biology of the Gene

View post:
Molecular Genetics - Genetics Conferences

Genetics

Getting tumors tested for genetics is the latest theory to help drugs target cancer – The Denver Post

Family photo provided by Katie Rosenbaum via AP

WASHINGTON Colon cancer. Uterine cancer. Pancreatic cancer. Whatever the tumor, the more gene mutations lurking inside, the better chance your immune system has to fight back.

Thats the premise behind the recent approval of a landmark drug, the first cancer therapy ever cleared based on a tumors genetics instead of the body part it struck first. Now thousands of patients with worsening cancer despite standard treatment can try this immunotherapy as long as genetic testing of the tumor shows theyre a candidate.

Its like having a lottery ticket, said Johns Hopkins oncologist Dr. Dung Le, who helped prove the new use for the immunotherapy Keytruda. Weve got to figure out how to find these patients, because its such a great opportunity for them.

Today, doctors diagnose tumors by where they originate breast cancer in the breast, colon cancer in the colon and use therapies specifically tested for that organ. In contrast, the Food and Drug Administration labeled Keytruda the first tissue-agnostic treatment, for adults and children.

The reason: Seemingly unrelated cancers occasionally carry a common genetic flaw called a mismatch repair defect. Despite small studies, FDA found the evidence convincing that for a subset of patients, that flaw can make solid tumors susceptible to immunotherapy doctors otherwise wouldnt have tried.

We thought these would be the hardest tumors to treat. But its like an Achilles heel, said Hopkins cancer geneticist Bert Vogelstein.

And last month FDA Commissioner Scott Gottlieb told a Senate subcommittee his agency will simplify drug development for diseases that all have a similar genetic fingerprint even if they have a slightly different clinical expression.

Its too early to know if whats being dubbed precision immunotherapy will have lasting benefits, but heres a look at the science.

WHOS A CANDIDATE?

Hopkins estimates about 4 percent of cancers are mismatch repair-deficient, potentially adding up to 60,000 patients a year. Widely available tests that cost $300 to $600 can tell whos eligible. The FDA said the flaw is more common in colon, endometrial and gastrointestinal cancers but occasionally occurs in a list of others.

Say, have I been tested for this?' is Les advice for patients.

MUTATIONS AND MORE MUTATIONS

Most tumors bear 50 or so mutations in various genes, Vogelstein said. Melanomas and lung cancers, spurred by sunlight and tobacco smoke, may have twice as many. But tumors with a mismatch repair defect can harbor 1,500 mutations.

Why? When DNA copies itself, sometimes the strands pair up wrong to leave a typo a mismatch. Normally the body spell checks and repairs those typos. Without that proofreading, mutations build up, not necessarily the kind that trigger cancer but bystanders in a growing tumor.

THE PLOT THICKENS

Your immune system could be a potent cancer fighter except that too often, tumors shield themselves. Mercks Keytruda and other so-called checkpoint inhibitors can block one of those shields, allowing immune cells to recognize a tumor as a foreign invader and attack. Until now, those immunotherapies were approved only for a few select cancers Keytruda hit the market for melanoma in 2014 and they work incredibly well for some patients but fail in many others. Learning whos a good candidate is critical for drugs that can cost $150,000 a year and sometimes cause serious side effects.

In 2012, Hopkins doctors testing various immunotherapies found the approach failed in all but one of 20 colon cancer patients. When perplexed oncologists told Vogelstein, a light bulb went off.

Sure enough, the one patient who fared well had a mismatch repair defect and a mind-boggling number of tumor mutations. The more mutations, the greater the chance that at least one produces a foreign-looking protein that is a beacon for immune cells, Vogelstein explained.

It was time to see if other kinds of cancer might respond, too.

WHATS THE DATA?

The strongest study, published in the journal Science, tested 86 such patients with a dozen different cancers, including some who had entered hospice. Half had their tumors at least shrink significantly, and 18 saw their cancer become undetectable.

Its not clear why the other half didnt respond. Researchers found a hint, in three patients, that new mutations might form that could resist treatment.

But after two years of Keytruda infusions, 11 of the complete responders have stopped the drug and remain cancer-free for a median of eight months and counting.

Catherine Katie Rosenbaum, 67, is one of those successes. The retired teacher had her uterus removed when endometrial cancer first struck, but five years later tumors returned, scattered through her pelvis and colon. She tried treatment after treatment until in 2014, her doctor urged the Hopkins study.

Rosenbaum took a train from Richmond, Virginia, to Baltimore for infusions every two weeks and then, after some fatigue and diarrhea side effects, once a month. Then the side effects eased and her tumors started disappearing. A year into the study she was well enough to swim a mile for a Swim Across America cancer fundraiser.

Nothing else had worked, so I guess we could say it was a last hope, said Rosenbaum, who now wants other patients to know about the option.

___

This Associated Press series was produced in partnership with the Howard Hughes Medical Institutes Department of Science Education. The AP is solely responsible for all content.

Read more from the original source:
Getting tumors tested for genetics is the latest theory to help drugs target cancer - The Denver Post

Genetics

Genetics of Canine Personality Traits – The Bark (blog)

The influence of genes on personality and behavior is of great interest to people who love dogs as well as to scientists studying the genetics of animal behavior. Since dogs personalities play a major role in their ability to function as our companions as well as to carry out a variety of tasks as working dogs, its important to understand the contribution of genetics on behavior. It is well established that genetics plays a large role, as evidenced by behavioral differences between breeds. Even substantial differences in behavior within breeds can be accounted for by genetic variation.

One of the challenges to studying behavioral genetics is that large sample sizes are required because there are so many factors that influence behavior (e.g. early environment, training methods, various lifestyle factors). To achieve adequately large sample sizes in research is both expensive and time consuming, sometimes prohibitively so. A recent study called Genetic Characterization of Dog Personality Traits took a creative approach to meet this challenge.

The scientists were interested in genetic contributions to personality, defined as individual consistency in behavioral responsiveness to stimuli and situations. Researchers took advantage of the substantial knowledge people have about their own dogs personalities to explore genetic contributions to personality traits. Their work shows that it is possible to detect genetic variation in dog personality traits by using questionnaires to collect large quantities of useful data.

In this recent study, researchers used the C-BARQ (Canine Behavioral Assessment Research and Questionnaire) as well as a separate questionnaire about demographics to study 1975 UK Kennel Club-registered Labrador Retrievers. The C-BARQ allowed each dog to be scored for the following personality traitsAgitated When Ignored, Attention-Seeking, Barking Tendency, Excitability, Fetching, Fear of Humans and Objects, Fear of Noises, Non-Owner Directed Aggression, Owner-Directed Aggression, Separation Anxiety, Trainability and Unusual Behavior.

The additional questionnaire collected data about the dogs age, coat color, sex, neuter status, housing, health status, exercise, daily exercise and the role of the dog. (The various roles were gun dog, show dog and pet dog.) To gather genetic information, the study took advantage of the dogs pedigrees, which involved 29 generations and 28,943 dogs. Further genetic data on the dogs were obtained as part of a different study using standard genomic methods and genetic markers, with 885 dogs from that study also participating in the C-BARQ portion of the research. In the analysis, the researchers estimated heritability of personality traits based on both the pedigree and on the genomic data.

The researchers found that fetching has a higher heritability rating than any other personality trait. Interestingly, some previous studies have lumped trainability with fetching ability, which results in lower heritability scores for both of them. This study also revealed a considerable genetic component to the fear of noises. Aggression directed towards owners showed no genetic component at all, while aggression towards strangers had a moderate genetic component.

Many behavioral traits are polygenic (influenced by a large number of genes, with each one often having a small effect) and also have significant environmental influences, which means that it is difficult to determine genomic associations. Estimates of heritability are likely to increase with technological advances in genetic work.

The importance of this study is that it shows that genetic variance can be detected and studied with the use of questionnaires filled out by owners. It also reveals that grouping responses into behavioral factors may make it harder to detect the genetic influence on various traits.

Read more here:
Genetics of Canine Personality Traits - The Bark (blog)

Genetics

Interleukin Shutting Down Genetic Testing Program, Lays Off Staff – GenomeWeb

NEW YORK (GenomeWeb) Interleukin Genetics on Monday announced that it would suspend its genetic testing program for severe gum disease and elevated systemic inflammation over the next 60 days after it was unable to defer a debt payment.

The Waltham, Massachusetts-based firm said it would also lay off five employees, or 63 percent of its current workforce. The decisions come as the company pursues strategic alternatives, Interleukin CEO Mark Carbeau said in a statement.

Registering provides access to this and other free content.

Already have an account? .

Read more here:
Interleukin Shutting Down Genetic Testing Program, Lays Off Staff - GenomeWeb

Genetics

Genetics causing arthritis possibly helped humans survive Ice – Kasmir Monitor

Editor in Chief : Zafar Meraj Email: zafarmeraj@gmail.com Editor & Publisher : Shamim Meraj Email: shamim.meraj@gmail.com Advertising & Circulation : Irfan Malik (+91-9419036322) Email: irfanmalikm@gmail.com Printed at : Abid Enterprises (Zainakote), Srinagar Published from : 1 Residency Road, Press Enclave, Srinagar - 190001 Editorial : Ph No: +91-2452217, 2452578 FAX: +91-194-2477676 Feedback & Suggestions : kashmirmonitor@gmail.com

View post:
Genetics causing arthritis possibly helped humans survive Ice - Kasmir Monitor

Physiology

Medical Physiology – 9781455743773 | US Elsevier Health Bookshop

I Introduction

Chapter 1 Foundations of Physiology

II Physiology of Cells and Molecules

Chapter 2 Functional Organization of the Cell

Chapter 3 Signal Transduction

Chapter 4 Regulation of Gene Expression

Chapter 5 Transport of Solutes and Water

Chapter 6 Electrophysiology of the Cell Membrane

Chapter 7 Electrical Excitability and Action Potentials

Chapter 8 Synaptic Transmission and the Neuromuscular Junction

Chapter 9 Cellular Physiology of Skeletal, Cardiac, and Smooth Muscle

III The Nervous System

Chapter 10 Organization of the Nervous System

Chapter 11 The Neuronal Microenvironment

Chapter 12 Physiology of Neurons

Chapter 13 Synaptic Transmission in the Nervous System

Chapter 14 The Autonomic Nervous System

Chapter 15 Sensory Transduction

Chapter 16 Circuits of the Central Nervous System

IV The Cardiovascular System

Chapter 17 Organization of the Cardiovascular System

Chapter 18 Blood

Chapter 19 Arteries and Veins

Chapter 20 The Microcirculation

Chapter 21 Cardiac Electrophysiology and the Electrocardiogram

Chapter 22 The Heart As a Pump

Chapter 23 Regulation of Arterial Pressure and Cardiac Output

Chapter 24 Special Circulations

Chapter 25 Integrated Control of the Cardiovascular System

V The Respiratory System

Chapter 26 Organization of the Respiratory System

Chapter 27 Mechanics of Ventilation

Chapter 28 Acid-Base Physiology

Chapter 29 Transport of Oxygen and Carbon Dioxide In the Blood

Chapter 30 Gas Exchange in the Lung

Chapter 31 Ventilation and Perfusion of the Lungs

Chapter 32 Control of Ventilation

VI The Urinary System

Chapter 33 Organization of the Urinary System

Chapter 34 Glomerular Filtration and Renal Blood Flow

Chapter 35 Transport of Sodium and Chloride

Chapter 36 Transport of Urea, Glucose, Phosphate, Calcium, Magnesium, and Organic Solutes

Chapter 37 Transport of Potassium

Chapter 38 Urine Concentration and Dilution

Chapter 39 Transport of Acids and Bases

Chapter 40 Integration of Salt and Water Balance

VII The Gastrointestinal System

Chapter 41 Organization of the Gastrointestinal System

Chapter 42 Gastric Function

Chapter 43 Pancreatic and Salivary Glands

Chapter 44 Intestinal Fluid and Electrolyte Movement

Chapter 45 Nutrient Digestion and Absorption

Chapter 46 Hepatobiliary Function

VIII The Endocrine System

Chapter 47 Organization of Endocrine Control

Chapter 48 Endocrine Regulation of Growth and Body Mass

Chapter 49 The Thyroid Gland

Chapter 50 The Adrenal Gland

Chapter 51 The Endocrine Pancreas

Chapter 52 The Parathyroid Glands and Vitamin D

IX The Reproductive System

Chapter 53 Sexual Differentiation

Chapter 54 The Male Reproductive System

Chapter 55 The Female Reproductive System

Chapter 56 Fertilization, Pregnancy, and Lactation

Chapter 57 Fetal and Neonatal Physiology

X Physiology of Cells and Molecules

Chapter 58 Metabolism

Chapter 59 Regulation of Body Temperature

Chapter 60 Exercise Physiology and Sports Science

Chapter 61 Environmental Physiology

Chapter 62 The Physiology of Aging

Go here to see the original:
Medical Physiology - 9781455743773 | US Elsevier Health Bookshop

Physiology

Department of Physiology

The Department of Physiology has a long-standing tradition of excellence. Our faculty, trainees, and staff seek to understand how the human body works from the head down to the toes and everything in between. Together, we exploit the range of available model systems to understand physiological processes at a mechanistic and integrated level in health with the explicit goal of understanding human disease and identifying potential therapeutics.

Visit link:
Department of Physiology

Physiology

Kinesiology professor earns distinguished lectureship award from the American Physiological Society – Manhattan Mercury (subscription)

David C. Poole, professor of exercise physiology and co-director of the Cardiorespiratory Exercise Laboratory in the kinesiology, and anatomy and physiology departments, will receive the Edward F. Adolph Distinguished Lectureship Award from the Environmental and Exercise Physiology, or EEP, section of the American Physiological Society.

The award and lecture will be presented at the Experimental Biology meeting in San Diego in April 2018. The award recognizes an eminent research scholar who has made meritorious contributions to the areas of environmental, exercise, thermal or applied physiology and who also is an outstanding public speaker.

Pooles research examines the limitations in the oxygen transport pathway especially at the muscle microcirculatory level. This work has been funded by the National Institutes of Health for more than 20 years. Discoveries made by Poole and his colleagues and students have helped inspire and drive major clinical trials advancing novel therapeutic treatments to reduce morbidity and mortality in heart failure patients in the U.S. and worldwide. This work also is germane to understanding the limitations to athletic performance and the exercise intolerance that develops with aging. He has authored three books and numerous chapters in major academic textbooks and regularly presents his work before national and international scientific audiences.

Poole began his higher education in England, where he earned his bachelors degree with honors in applied physiology and sports science from Liverpool Polytechnic. His masters degree and doctorate are from University of California, Los Angeles in kinesiology specializing in physiology. He was awarded the higher Doctor of Science in physiology from John Moores University in Liverpool, which recognized his outstanding contributions to the field. He was the first recipient of that award, which was conferred by the British first lady, Cherie Booth Blair.

Pooles career is filled with recognition and awards in grants, for research and, most importantly, for his teaching and research with students. He is extensively published with more than 200 peer-reviewed papers in journals such as Circulation Research, Journal of Clinical Investigation, Respiration Physiology and Neurobiology, European Journal of Applied Physiology, American Journal of Physiology and the Journal of Applied Physiology. This work has been cited more than 14,000 times in the scientific literature as well as featured on television, newspaper articles and syndicated radio networks.

Read the original here:
Kinesiology professor earns distinguished lectureship award from the American Physiological Society - Manhattan Mercury (subscription)