Trump supporters know Trump lies. They just don’t care. – Vox

During the campaign and into his presidency Donald Trump repeatedly exaggerated and distorted crime statistics. Decades of progress made in bringing down crime are now being reversed, he asserted in his dark speech at the Republican National Convention in July 2016. But the data here is unambiguous: FBI statistics show crime has been going down for decades.

CNNs Jake Tapper confronted Trumps then-campaign manager, Paul Manafort, right before the speech. How can the Republicans make the argument that somehow its more dangerous today, when the facts dont back that up? Tapper asked.

People dont feel safe in their neighborhoods, Manafort responded, and then dismissed the FBI as a credible source of data.

This type of exchange where a journalist fact-checks a powerful figure is an essential task of the news media. And for a long time, political scientists and psychologists have wondered: Do these fact checks matter in the minds of viewers, particularly those whose candidate is distorting the truth? Simple question. Not-so-simple answer.

In the past, the research has found that no only do facts fail to sway minds, but they can sometimes produce whats known as a backfire effect, leaving people even more stubborn and sure of their preexisting belief.

But theres new evidence on this question thats a bit more hopeful. It finds backfiring is rarer than originally thought and that fact-checks can make an impression on even the most ardent of Trump supporters.

But theres still a big problem: Trump supporters know their candidate lies, but that doesnt change how they feel about him. Which prompts a scary thought: Is this just a Trump phenomenon? Or can any charismatic politician get away with being called out on lies?

In 2010, political scientists Brendan Nyhan and Jason Reifler published one of the most talked about (and most pessimistic) findings in all of political psychology.

The study, conducted in the fall of 2005, split 130 participants into groups who read different versions of a news article about President George W. Bush defending his rationale for engaging in the Iraq War. One version merely summarized Bushs rationale There was a risk, a real risk, that Saddam Hussein would pass weapons or materials or information to terrorist networks. Another version of the article offered a correction that, no, there was not any evidence Saddam Hussein was stockpiling weapons of mass destruction.

The results were stunning: Staunch conservatives who saw the correction became more likely to believe Hussein had weapons of mass destruction. (In another experiment, the study found a backfire on a question about tax cuts. On other questions, like on stem cell research, there was no backfire.)

Backfire is a pretty radical claim if you think about it, Ethan Porter, a political scientist at George Washington University, says. Not only do attempts to correct information not sink in, but they can actually make conflicts even more intractable. It means earnest attempts to educate the public may actually making things worse. So in 2015, Porter and a colleague, Thomas Wood at the Ohio State University, set out to try to replicate the effect for a paper (which is currently undergoing peer review for publishing in the journal Political Behavior).

And among 8,100 participants and on the sort of political questions that tend to bring out hardline opinions Porter and Wood hardly found any evidence of backfire. (The one exception, interestingly, was the question of weapons of mass destruction in Iraq. But even on that, the backfire effect went away when they tweaked the wording of the question.)

Theres no evidence that backfire describes a common reflex of Americans when it comes to facts, Porter assures me. (Nyhan, for his part, never asserted that backfire was ubiquitous, just that it was a possible and particularly consequential result of fact-checking.)

Stories of failed replications in social psychology often grow ugly, with accusations of bullying and scientific misconduct flying in both directions. But in this story, researchers decided to team up to test the idea again.

The fact that Nyhan and Reiflers breakthrough study didnt replicate isnt a shocker. This happens all the time in science. One group of researchers publishes a breakthrough finding. Another lab tries to replicate it, and fails.

But instead of feuding, Nyhan, Reifler, Porter, and Wood came together to conduct a new study.

If you believe in social science, this is an ideal way to resolve a dispute, Porter says. If we can devise an experiment together, then the results are going to have something meaningful to say about our differing understandings of the world.

So the four researchers collaborated on two experiments with a wide range of people as subjects, including Trump and Hillary Clinton supporters.

The first experiment drew on Trumps exaggerations of crime statistics.

In the experiment, participants read one of five news articles. One was a control article about bird watching. Another just contained a summary of Trumps message without a correction. The third was an article that included a correction. The fourth included a correction, but then also a line of pushback from onetime Trump campaign manager Paul Manafort, who said the FBIs statistics were not to be trusted. The fifth included a line where Manafort really laid into the FBI, saying, "The FBI is certainly suspect these days after what they just did with Hillary Clinton.

The thinking here: If anyone should be able to incite a backfire effect among Trump supporters, its Trumps campaign director. Manafort gives Trump supporters cover. They can reject the correction and cite one of the most influential figures in the campaign. And if theres a time backfire ought to occur, its during a presidential campaign, when our political identities are fully activated.

But it didnt happen. On average, all the studys participants were more likely to accept the correction when they read it. Trump supporters were more hesitant to accept it than Clinton supporters. But thats not backfire; thats reluctance. Manaforts assertion that the FBI statistics were not to be trusted didnt make much of a difference either.

Everyones beliefs about changing crime over the last 10 years became more accurate in the face of a correction, Nyhan says.

The research group then conducted a second experiment during the presidential debates. This one was conducted in near-real time: On the night of the first presidential debate, the group ran an online study with 1,500-plus participants.

The study focused on one Trump claim in particular. Trump said thousands of jobs [are] leaving Michigan, Ohio ... theyre just gone.

This, again, isnt true. The Bureau of Labor Statistics actually finds both states created 70,000 new jobs in the previous year. Half of the participants saw the correction; the other half did not.

Again, the researchers found no evidence of backfire. Its worth underscoring: This was on the night of the first presidential debate. Its the Super Bowl of presidential politics. If corrections arent going to backfire during a debate, when will they?

In both experiments, the researchers couldnt find instance of backfire. Instead, they found that corrections did what they were intended to do: nudge people toward the truth. Trump supporters were more resistant to the nudge, but they were nudged all the same.

But heres the kicker: The corrections didnt change their feelings about Trump (when participants in the corrections conditions were compared with controls).

People were willing to say Trump was wrong, but it didnt have much of an effect on what they felt about him, Nyhan says.

So facts make an impression. They just dont matter for our decision-making, which is a conclusion thats abundant in psychology science.

(And if youre thinking, How could one short experimental manipulation really change how much participants like Trump? know that other research shows its possible. Notably, studies conducted during the election found that just reminding white voters they may be a racial minority one day increased support for Trump.)

The big question is: To what extent do those results generalize beyond Trump himself? says Nyhan. Many of his supporters may have to come to terms with his records of misstatements by the time this study was conducted.

Nyhan is reluctant to place the blame on Trump supporters themselves its just human nature to stand by our political partys candidates. But he says theres something wrong with our institutions, norms, and party leaders who enable the rise of candidates who constantly lie.

At least its nice to know that facts do make an impression, right? On the other hand, we tend to avoid confronting facts that run hostile to our political allegiances. Getting partisans to confront facts might be easy in the context of an online experiment. Its much harder to do in the real world.

These results have not yet been peer-reviewed or published in an academic journal so treat them as preliminary. But I did run them by several political science and psychology researchers for a sniff test.

These two experiments are well done, and the data analysis appears to straightforward and correct: we observe clear movement on subjects beliefs as a result of factual corrections, Alex Coppock, who researches political decision-making at Yale, writes in an email. This piece is nice because it adds to the (small but growing) consensus that backfire effects, if they exist at all, are rare.

Others commended the researchers for collaborating in the face of conflicting results. I think this is exactly how the scientific process should operate as we try to explain human behavior, Asheley Landrum, who researches politically motivated reasoning at Texas Tech, writes. Social scientists, arguably, should be even more aware of motivated reasoning, recognizing that it also occurs in scientists.

Nyhans research is about seeing if attitude change is possible. And this research often comes to frustrating ends. In one study, he and Reifler tested out four different interventions to try to nudge vaccine skeptics away from their beliefs. None made a difference. Though it is illusive, at the least, he found a little attitude change within himself.

Jason [Reifler] and I have definitely updated our beliefs about the prevalence of the backfire effect, Nyhan says. He wont say its been debunked. But hes moving in that direction.

Link:
Trump supporters know Trump lies. They just don't care. - Vox

How a Syrian Writer Takes on War – New Republic

Many of the stories are about power, and the violence, both implicit and explicit, imbued in its existence. The entirety of Ants reads When I crushed a large number of ants by accident with my feet, I realized that weakness is punishment without wrongdoing. It has that special quality that give allegories their power: It seems obvious, but only after you finish it. Many of the stories use animals or household objects as a window into the human. Later, in Greatest Creatures, a mother ant and a son ant are discussing which species is better, humans or ants. The story ends when the mother points out that, though humans have many geniuses among them, theyve been unable to prevent the catastrophic from occurring, and the fact that ants have prevented it makes them better. Like Alomars best work, it makes a point that is equal parts silly and compelling: By most metrics, humans seem a great deal more important than ants, but it also seems obvious that whichever species finds a way to avoid destroying itself is the better one.

In Who Deserves a Muzzle? a dog watches his owners shout at one another and considers whether it makes sense that he be required to wear a muzzle and collar when his behavior is so much better than theirs. Later, in They Dont Know How to Bark, two dogs reflect with sympathy and pity on humans poor sense of smell and ugly language. Again, Alomar is being fundamentally ridiculous while making an odd sort of sense: Hes writing against the arrogance that can come from a limited perspective. But these are not childrens fables: Alomar often centers greed, arrogance, cruelty, and above all, folly. When inanimate objects attempt to replicate what they see from humans as a means of self-determination, it has disastrous consequences, like in the collections title story:

Some of the teeth of the comb were envious of human class differences. They strived to increase their height, and, when they succeeded, began to look with disdain on their colleagues below. After a little while, the combs owner felt a desire to comb his hair. But when he found it in this state, he threw it in the garbage.

In Alomars world, human behavior seems destructive, even to people, as long as theyre not the ones theyre observing. The change in perspective is what reveals human beings as ridiculous: If it is ridiculous for a comb to be vain, how ridiculous is it for a person?

Throughout the stories, humanity is often portrayed as the enemy of everything within its striking distance. But the harm is often inflicted in the background, like its just something that happens. When Alomar turns his attention to the elements that make that harm possible, things begin to feel much less silly. In A Taste, the devil tastes a drop of human hatred, is poisoned, and dies. Alomar hits this note again in Human Malice, where an argument between a nuclear bomb and a grenade over which is more evil is ended when human malice intervenes and points out that it created them both. Alomar posits hatred and malice as elements of human nature, not its sum total, but in emphasizing their destructive powers, he recognizes their control over the way huge swaths of the world lives. The effect is that Alomars stories give brief flashes of insight into the magnitude of human evil, like staring directly into the sun for a moment before having to look away.

Its not that Alomar is cynical; hes exhausted. Journey of Life, the first story in The Teeth of the Comb, follows a nameless, sexless character as they pour over maps and walk through crowds shouting for a beloved they never find. The true object of the search is only revealed in the last line: I stood on my shaking legs and continued my journey, searching for humanity until the last moment. The character maintains hope because they are willing to continue searching, but the reader can see the truth: theyll be looking forever. Importantly, Alomar does not denigrate his character for their wrongheadedness; instead, he casts the quest as noble, in spite of its futility.

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How a Syrian Writer Takes on War - New Republic

Dak Prescott: Great Guy Who Gets Pumped to Bad Music – D Magazine

It pains me to write this post, because Dak Prescott seems fairly unimpeachable character-wise. Especially after reading this Sports Illustrated interview, in which last years Rookie of the Year talks about his effort to raise $150,000 to bolster awareness to immunology research in the wake of his mothers death from cancer in 2013. He also dings Zeke for his ESPN the Magazine Body Issue cover, saying he should use his platform to do things like Im doing such asthis cancer campaign instead of doing his thing for the body issue and doing photo shoots.

Side-eye notwithstanding, look at that character!

I wish Id stopped reading there.SI just had to include this tidbit:

SI:Favorite song right now?

Prescott:My favorite song ever isDrops of Jupiterby Train. Its one of the songs I listen to before games. Its chill, but its also upbeat at the same time.

But, you know what, if that gets him going, Cowboys fans cant really complain too much. Maybe thats why he seems so calm in the pocket.Anyway, head here to learn more about the Ready. Raise. Rise. campaign that Prescotts aligning withtoraise money for immunology research; its a dual effort with Bristol-Myers Squibb.

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Dak Prescott: Great Guy Who Gets Pumped to Bad Music - D Magazine

Preference for order rather than uncertainty related to brain anatomy – Bel Marra Health

Home Brain Function Preference for order rather than uncertainty related to brain anatomy

There are people out there who prefer order in their lives rather than unpredictability. Feeling secure in their work and relationships is something most people take great comfort in. These concepts appear foreign to some people who reject stability in lieu of impulsiveness.

There are pros and cons to each. Certain medical conditions can even present with some of these traits, such as obsessive-compulsive disorder and autism.

A team of behavior neuroscientists believe they have identified changes in brain regions that may explain why some prefer order while others do not.

Studies in rats assessing their ability to work for a reward under both stable and variable conditions provided the researchers more insight into how the brain operates. The areas of the brain studied included the orbitofrontal cortex and the basolateral amygdala regions of the brain.

The experiment worked by using sugar pellets as a reward for choosing between two images side by side. The rats made selections by pressing their noses onto a touch sensitive screen. When a rat touched an image, a sugar pellet would be dispensed at a predictable range of timein this case, 10 seconds. Touching the other image produced a sugar pellet at a more varied amount of time. This second image would make the rat wait as little as five seconds or as long as 15 seconds.

The rat subjects performed this experiment for a month at a time for about 45 minutes a day.

After assessing all the data, the researchers discovered that the rats were able to detect fluctuations in wait times. Variations correlated with the amount of a brain protein called gephyrin in the basolateral amygdala regions, which doubled during unpredictable wait times.

To further test this correlation, they made one option better than the other, with the rats predictably choosing the faster option for the sugar pellet over a short period of time.

Interestingly, rats without a functional basolateral amygdala learned more slowly, but caught up in a day or two. However, rats without a functional orbitofrontal cortex did not learn at all. They treated each experience as brand new.

Its as if the rats had forgotten or had no record of the full range of possible outcomes. This singled out the orbitofrontal cortex as having a bigger role than previously thought.

Overall, all the rats chose the risky option more often, with the exception of the rats without a functional basolateral amygdala. These rats were risk-averse throughout the duration of the experiment.

Earlier research has shown that the orbitofrontal cortex and the basolateral amygdala share anatomical connections and are both involved in decision-making.

The researchers believe that changes in these brain regions and brain proteins may explain why a person prefers certain outcomes rather than others. The gephyrin gene has even been linked to autisma mental condition characterized by difficulty with communication but also repetitive behavior.

Related: Obsessive-compulsive disorder (OCD) questionnaire can also help determine the risk of depression and anxiety

Related Reading:

Scientists may have linked IBS gut bacteria to behavior changes

ADHD, autism similarities to be revealed by research to develop effective behavioral therapies

https://elifesciences.org/articles/27483

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Preference for order rather than uncertainty related to brain anatomy - Bel Marra Health

Even in the era of fake news, facts can shape our opinions – Grist

In a world wherepost-truth was 2016s word of the year, many people are starting to doubt the efficacy of facts. Can science make sense of anti-science and post-truthism? More generally, how can we understand what drives peoples beliefs, decisions, and behaviors?

Scientists have developed many theories to describehow people process and think about information. Unfortunately, theres an increasing tendency to see people as creatures whose reasoning mechanisms are largely dependent on a narrow set of processes. For example, one popular theory suggests that if we just communicate more accurate information to people, their behavior will change accordingly. Another suggests that people will reject evidence if it threatens their deeply held cultural worldviews and associated feelings.

Its more important than ever that our approach to communication is evidence-based and built on a strong, theoretical foundation. Many of these models contribute valuable insights and can help us design better communication, but each on its own is incomplete. And science communicators have a tendency to oversimplify, focusing on a single model and disregarding other theories.

We suggest that this is a dangerous practice and less effective thana more nuanced and holistic view. The apparent choice between fact and feeling, or between cognition and culture, is a false dilemma. In reality, both are related and address different pieces of the decision-making puzzle.

One well-known theory about how people absorb new facts is the information deficit model. The main idea here is straightforward: If you throw more facts at people, theyll eventually come around on an issue.

Most behavioral science scholars agree that this model of human thinking and behavioris clearly incomplete people rely on a range of other cues besides facts in guiding their attitudes and behavior. For example, sometimes we simply act based on how we feel about an issue. Unfortunately, the facts dont always convince.

But the term information deficit is problematic, too. People tend to have limited information in most areas of life. For example, we often dont know the thoughts and feelings of other people we trust and value. Similarly, we might have limited knowledge about appropriate cultural norms when traveling to a new country, and so on. Information deficit isnt a very meaningful term to use to theorize about human thinking.

Another theory about human thinking is called cultural cognition. In brief, it suggests that our cultural values and worldviews shapehow we think about science and society.

Its easy to be duped into thinking of the human brain as a sponge that soaks up only the information it wants to believe. For example, the theory suggests that peoples position on divisive issues such as climate change is not informed by scientific evidence, but rather by the strong commitment people have to their political groups and ideologies. The idea is that to protect our cultural worldviews, we actively reject evidence that threatens them think of someone who fears that government action on climate change undermines the free market.

In short, this narrative sounds appealing on the surface, as humans organize themselves in groups, and much psychological research has shown that we derive part of oursocial identities from the group affiliations we maintain.

Yet, its focus is overly narrow, and theres a logical fallacy in this conception of human thinking. We belong to many groups at any given time and we juggle many different public and private identities. The real question is about nuance; when and under what conditions is someone motivated to reject scientific facts in favor of their cultural worldview?

To throw all our fact-disseminating eggs into one or the other theoretical basket is oversimplistic and deprives us of important insights.

A more nuanced perspective recognizes that facts and information are embedded in social and cultural contexts. For example, peoples perception of expert consensus matters a great deal, especially on contested issues, and is often described as agateway belief that influences a range of other attitudes about an issue. The near-unanimous consensus that vaccines do not cause autism or that climate change is human-caused are all scientific facts. At the same time, consensus information is also inherently social: It describes the extent of agreement within an influential group of experts.

People often want to beaccurate in their views, and, in an uncertain world bounded by limited time and effort, we make strategic bets on what information to take into account. Consensus acts as a natural heuristic, or mental shortcut, for complicated scientific issues.Numerousstudies have found that highlighting scientific agreement on human-caused global warming can help neutralize and reduce conflicting views about climate change.

Similarly, while some studies have found a limited effect of knowledge on judgment, when you dig deeper into the data, a more nuanced and insightful picture emerges. For example, some studies claim that adeficit in scientific knowledge does not explain why people are divided on contested issues such as climate change. But whats being measured in these experiments matters. Indeed, indicators such as how well people understand numbers or their scientific literacy which is what some of these studies actually quantify are categorically different from measuring specific knowledge people have about a topic such as climate change. In fact, a survey across six countries found that when peopleunderstand the causes of climate change, their concern increases accordingly, irrespective of their values. Similarly,otherstudies show that explanations about the mechanisms of climate change can reduce biased evaluations of evidence as well as political polarization.

In short, facts do matter.

Indeed, there is no need to throw outthe baby with the bathwater. Instead, we need to dispel false dichotomies and folk psychology about human thinking that currently dominate the media. Repeating the story that people dont care about facts runs the risk of becoming a self-fulfilling prophecy. A holistic view acknowledges that people rely on cognitive shortcuts and emotions, care about social norms and group identities and are sometimes motivated in their reasoning, but it also recognizes the research showing that most people want to fundamentally hold accurate perceptions about the world.

This is particularly important as the public is currently hampered by misinformation and fake news. In two separatestudies, we each found that misinformation about climate change has a disproportionate influence on public attitudes and opinion. However, we also found that inoculating people against the false arguments neutralized misinformations influence, across the political spectrum. In essence, teaching people what false arguments might be deployed helped them overcome their cultural biases. Other work similarlyshows that the politicization of science can be counteracted with inoculation.

People are complex, social, and affected by a diverse range of influences depending on the situation. We want to hold accurate views, but emotion, group identities, and conflicting goals can get in the way. Incorporating these different insights into human thinking enriches our understanding of how people form opinions and make decisions.

Effective science communication requires an inclusive, holistic approach that integrates different social science perspectives. To simplistically focus on a single perspective paints a limited and increasingly inaccurate view of how humans form judgments about social and scientific issues.

Link:
Even in the era of fake news, facts can shape our opinions - Grist

As ye sow, so shall ye reap – The Intelligencer

Recently, much hay has been made about a Guest Opinion that claimed people who display a Hate has no home here sign are hypocrites in that such signs are code for I hate Trump.

Although it is usually impossible to judge the intentions of actions, the display of such signs logically demands that the owners claim they hate no one, that they are sending a message to some who, in their opinion, do hate others, and that they are morally superior to such haters.

The problem is that the sentiment Hate has no home here can only be justified religiously under the rubric that humans are endowed by their Creator with certain inalienable rights. Secularism has as its basis that religious beliefs are merely personal, biased world views. Even if God does exist, he, or at least his revelations to humanity, are irrelevant to the public square.

Secularism appears to be stuck in the Enlightenment, which claimed that morals could be justified by pure, detached reason, as if that overall project has not been discredited by academics for over 100 years.

So, without a religious basis, morality becomes a mere shouting match over who can scream the loudest or act the most indignant. Philosopher Friedrich Nietzsche wrote all animals ... strive instinctively for an optimum combination of favourable (sic) conditions which allow them to expend all their energy and achieve their maximum feeling of power. Thus, if person A thinks it is to his or her advantage to discriminate against person B, who are you to judge? One could even argue this is perfectly Darwinian. Ironically, the quote comes from Nietzsches book, Beyond Good and Evil.

We have here a clear example of how the pen is mightier than the sword. The ideas that permeate a culture are far more dangerous than even going to war. Barack Obamas dissemination of his functional atheism (as he was labeled by famous atheist Richard Dawkins) has had a far more pernicious effect on our culture than Donald Trumps personal puerile and bellicose behavior ever could. For example, the Family Research Council (admittedly a Christian organization) claims in its report Hostility to Religion: The Growing Threat to Religious Liberty in America, that there has been a 76 percent increase in violations (might we say hate toward?) of legitimate religious freedoms that can be tied directly to Obama administration policies.

Additionally, the hatred of the political left toward the political right is on display daily. The lack of condemnation over Kathy Griffins bloodied Trump head has been deafening. The shutdown at universities of speakers not following politically correct orthodoxy only makes our divisions worse. (So much for diversity and dialogue.)

Furthermore, what greater hate can there be toward a fellow human being than to support his or her execution before he or she is even born?

And, of course, people who have honest doubts about climate change are not met with logical counterargument but simply insulted. Take Trumps pullout from the Paris agreement. As columnist Charles Krauthammer pointed out, the agreement was completely non-binding, non-enforceable and allowed China and India to continue to put our planet in jeopardy for another 13 years. Predictably, there was a cacophony of catcalls skewering Trump for his alleged scientific naivet.

However, science does not work as straightforwardly as we are taught in school. Consider Thomas S. Kuhns 1962 book, The Structures of Scientific Revolutions. Parade magazines capsule review calls it a book of science as explained by a physicist and philosopher who suggested that understanding is not merely a matter of gathering the facts. The book demonstrates how scientific advancements actually happen and undercuts the justification for any arrogance on the part of those who respond with mere disdain to those, for example, who may have their doubts about climate change or its causes.

Recently, this paper editorialized and lamented that the courtroom appears to be the last bastion of decorum in a society where most people seem to think the rules apply to everybody but them. But given that progressives have spent the last 50 years undermining traditional sexual mores while naively thinking their rejection of some moral standards would not spread like a cancer to the remainder of human behavior, how could we not but have arrived at this point?

As ye sow, so shall ye reap.

Charles D. Dern, Ph.D., Plumstead, is an adjunct teacher of philosophy and theology.

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As ye sow, so shall ye reap - The Intelligencer

Immunotherapy drug targets tumor’s genetics instead of body part – Monroe Evening News

WASHINGTON (AP) Colon cancer. Uterine cancer. Pancreatic cancer.

Whatever the tumor, the more gene mutations lurking inside, the better chance your immune system has to fight back.

Thats the premise behind the recent approval of a landmark drug, the first cancer therapy ever cleared based on a tumors genetics instead of the body part it struck first.

Now thousands of patients with worsening cancer despite standard treatment can try this immunotherapy as long as genetic testing of the tumor shows theyre candidates.

Its like having a lottery ticket, said Johns Hopkins oncologist Dr. Dung Le, who helped prove the new use for the immunotherapy Keytruda. Weve got to figure out how to find these patients, because its such a great opportunity for them.

Today, doctors diagnose tumors by where they originate breast cancer in the breast, colon cancer in the colon and use therapies tested specifically for that organ.

In contrast, the Food and Drug Administration labeled Keytruda the first tissue-agnostic treatment, for adults and children.

Seemingly unrelated cancers occasionally carry a common genetic flaw called a mismatch repair defect. Despite small studies, the FDA found the evidence convincing that for a subset of patients, that flaw can make solid tumors susceptible to immunotherapy doctors otherwise wouldnt have tried.

We thought these would be the hardest tumors to treat, but its like an Achilles heel, said Hopkins cancer geneticist Bert Vogelstein.

Last month, FDA Commissioner Scott Gottlieb told a Senate subcommittee his agency will simplify drug development for diseases that all have a similar genetic fingerprint even if they have a slightly different clinical expression.

Its too early to know if whats being dubbed precision immunotherapy will have lasting benefits, but heres a look at the science.

WHOS A CANDIDATE?

Hopkins estimates about 4 percent of cancers are mismatch repair-deficient, potentially adding up to 60,000 patients a year.

Widely available tests that cost $300 to $600 can tell whos eligible.

The FDA said the flaw is more common in colon, endometrial and gastrointestinal cancers but occasionally occurs in a list of others.

Say, have I been tested for this? is Les advice for patients.

MUTATIONS AND MORE MUTATIONS

Most tumors bear 50 or so mutations in various genes, Vogelstein said. Melanomas and lung cancers, spurred by sunlight and tobacco smoke, may have twice as many. Tumors with a mismatch repair defect can harbor 1,500 mutations.

Why? When DNA copies itself, sometimes the strands pair up wrong to leave a typo a mismatch. Normally the body spell checks and repairs those typos.

Without that proofreading, mutations build up, not necessarily the kind that trigger cancer but bystanders in a growing tumor.

THE PLOT THICKENS

Your immune system could be a potent cancer fighter except that too often, tumors shield themselves.

Mercks Keytruda and other so-called checkpoint inhibitors can block one of those shields, allowing immune cells to recognize a tumor as a foreign invader and attack. Until now, those immunotherapies were approved only for a few select cancers Keytruda hit the market for melanoma in 2014 and they work incredibly well for some patients but fail in many others.

Learning whos a good candidate is critical for drugs that can cost $150,000 a year and sometimes cause serious side effects.

In 2012, Hopkins doctors testing various immunotherapies found the approach failed in all but one of 20 colon cancer patients. When perplexed oncologists told Vogelstein, a light bulb went off.

Sure enough, the one patient who fared well had a mismatch repair defect and a mind-boggling number of tumor mutations. The more mutations, the greater the chance that at least one produces a foreign-looking protein that is a beacon for immune cells, Vogelstein explained.

It was time to see if other kinds of cancer might respond, too.

WHATS THE DATA?

The strongest study, published in the journal Science, tested 86 such patients with 12 different cancers, including some who had entered hospice. Half had their tumors at least shrink significantly and 18 saw their cancer become undetectable.

Its not clear why the other half didnt respond. Researchers found a hint, in three patients, that new mutations might form that could resist treatment.

But after two years of Keytruda infusions, 11 of the complete responders have stopped the drug and remain cancer-free for a median of eight months and counting.

Catherine Katie Rosenbaum, 67, is one of those successes. The retired teacher had her uterus removed when endometrial cancer struck, but five years later tumors returned, scattered throughout her pelvis and colon.

She tried treatment after treatment until in 2014, her doctor urged the Hopkins study.

Rosenbaum took a train from Richmond, Virginia, to Baltimore for infusions every two weeks and then, after some fatigue and diarrhea side effects, once a month. Then the side effects eased and her tumors started disappearing.

A year into the study she was well enough to swim a mile for a Swim Across America cancer fundraiser.

Nothing else had worked, so I guess we could say it was a last hope, said Rosenbaum, who now wants other patients to know about the option.

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Immunotherapy drug targets tumor's genetics instead of body part - Monroe Evening News

A few drops of blood lead to a breakthrough in immunology – Radio Canada International

Not the sun, but a microscopic look at a specific gene in a specific cell that has led to a major advance in our understanding and treatment of auto-immune diseases. Photo Credit: Ciriaco Piccirillo, Research Institute of the McGill University Health Centre

It was one of those tragic cases in medicine.

A newly born child, just weeks old, had a severe auto-immune condition that could not be treated and which led irrevocably to his death.

With just a few drops of the childs blood, researchers led by a team in McGill University and the Research Institute-McGill University Health Centre (RI-MUHC) in Montreal, have painstakingly discovered the cause in a subset of so-called T-cells, and have created a solution that has major disease treatment implications.

Dr. Ciriaco Piccirillo led an international research team with input from the USA and Japan. He is an immunologist and senior scientist with the Infectious Diseases and Immunity in Global Health Programat the Research Institute-McGill University Health Centre (RI-MUHC), and a Professor of Immunology and Medicine at McGill University. He is also the Director of the newly created Centre of Excellence in Translational Immunology (CETI) at the RI-MUHC.

The baby boy died in 2009 of a rare and often fatal inherited genetic immune disorder called IPEX. The case involved the childs T-cells, and specifically the Treg cell, the immunosuppressive cells of the immune system.

These latter are a special kind of white blood cells or lymphocytes that regulate the bodies auto-immune response. They prevent other immune cells from attacking the bodys own tissues, as well as controlling immune responses against microbes and other non-pathogenic agents, such as pollen, dust or benign food groups. This is an important self-check built into the immune system to prevent excessive reaction.

When the immune response is not controlled it can cause damage to the body in diseases such as rheumatoid arthritis, Lupus, and Crohns disease as well as broader conditions such as asthma, allergies and cancer.

Through meticulous molecular research and availability of new highly sophisticated technology at the RI-MUHC, the team was able to determine a defect in a particular gene in the Treg cell which prevented it from properly acting in its regulatory role in dampening the immune system response.

Certain genes, but especially the FOXP3 gene are responsible for programming so-to-speak a T-cell to become a Treg cell.

What the team found from the babys blood was a rare mutation of the FOXP3 gene which negatively impacted its capacity to promote Treg cell development and function in humans.

After the intense research to detect the genetic defect in the specific FOXP3 gene, they developed a drug which appears able to correct the genetic defect resulting in an almost completely normally functioning Treg cell.

The teams research was published in the online journal Science-Immunology under the title Suppression by human FOXP3+ regulatory T cells requires FOXP3-TIP60 interactions (abstract HERE)

Further, while this should work in those rare patients with IPEX, professor Piccirillo says the team in now working on improving the drug to bolster its effects on the FOXP3 gene and developing Treg cells in other inflammatory and autoimmune diseases.

He says this likely will have far greater treatment possibilities in relation to a number of auto-immune diseases which are typically very difficult to treat.

The study was funded by the Canadian Institutes of Health Research, Canada Research Chair Program, National Institutes of Health and the Abramson Family Cancer Research Institute.

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A few drops of blood lead to a breakthrough in immunology - Radio Canada International

Jana Schwartz leads local 4-H’ers – Scottsbluff Star Herald

For Jana Schwartz, no two days are alike. Schwartz is a 4-H associate at the University of Nebraska-Lincoln Extension Center and helps coordinate 4-H projects within Scotts Bluff County.

One day, Schwartz may be helping with entries for the Scotts Bluff County Fair and spend all day in the office and another day, she may be out doing projects or at the Wildcat Hills teaching children about trees.

Schwartz said projects she coordinates vary from helping 4-H members with their own projects, helping them join clubs or entering students in the fair to the extension center taking part in teaching classrooms about agriculture and animal science, agricultural literacy and more.

One of the many projects Schwartz takes to classrooms is an embryology life cycle project where the students hatch chicken eggs within a classroom. They also teach about electricity, robotics and wearable technology.

Ive been in extension for 15 years now and I was a part of the 4-H program for about 8 years as a child. I really loved what the 4-H program did for me, Schwartz said. It gave me the opportunity to try new things and find out what I was good at.

Schwartz said she didnt go to college expecting to go into extension. Schwartz grew up in Chase County on a cattle ranch and thought shed go into something related to agriculture or veterinary medicine.

I started as a vet tech and ended up on this path, Schwartz said. I started with an internship in Dawes County and that lead to the job here in Scotts Bluff County.

Every state has an extension program that is tied to a university, here in Nebraska it is the University of Nebraska-Lincoln. The extension is an outreach program which takes any discoveries by the university that are applicable to the public.

For example, in Nebraska agriculture is the biggest portion of extension and producers are able to learn about the best practices for producing different agricultural products. However, the program also does a lot outside of agriculture such as youth development, 4-H, healthy living and nutrition.

The 4-H program started over 100 years ago in 1902 and its main purpose was to take research that scientists discovered to help producers have higher yields from corn.

They tried to teach the discoveries to the adults, but as adults, we dont maybe want to change the ways we are doing things, so people from the university started the first 4-H youth club and taught them new ways to produce crops, Schwartz said. The kids actually started to out-yield their parents.

Schwartz also said that the main purpose of 4-H is to teach kids life skills, but she said the life skills they taught 100 years ago are quite different from skills youth need to know now. Although things such as responsibility, trust, communication and leadership are still important to the organization, lessons and project categories have been tweaked to fit the times.

There are still projects that have to do with agriculture as well as cooking, sewing, robotics, photography, lots of science, technology, art and math, Schwartz said. Thats what youth are needing today.

Right now, Schwartz and members of the 4-H portion of the extension center are making sure that they are prepared for the Scotts Bluff County Fair.

Its kind of the 4-H members Super Bowl, so were making sure all of the details are taken care of so people and families have the best experience possible, Schwartz said.

Schwartz said her favorite thing about her job is the people and volunteers that she gets to work with.

The kids are amazing to work with and to see them grow and change and meet their potential is great, Schwartz said. Volunteers mean a lot to me because of how much they give to the program and what they do for the kids in their community.

Projects will be shown and judged from Saturday, July 22 through Sunday, Aug. 8 at the Scotts Bluff County Fairgrounds in Mitchell.

Call 308-632-1480 for more information on or questions about the local 4-H program.

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Jana Schwartz leads local 4-H'ers - Scottsbluff Star Herald

Tick-Tock: Men Also Have a Biological Clock – – Vital Updates – Vital Updates

The biological clock ticks not just for women, suggests new research that may overturn conventional thinking about mens virility as they age.

Whereas women undergo menopause as a clear indicator of decreased fertility, a similar biological mechanism in men was previously unknown. But new research into delivery rates among couples undergoing in vitro fertilization found that men hear the clock ticking, too.

The study, assessing nearly 19,000 cycles of in vitro fertilization, showed that, as a mans age increased, the success rate of fertilization went in the opposite direction.

Generally, we saw no significant decline in cumulative live birth when women had a male partner the same age or younger, said study author Dr. Laura Dodge, researcher with the Beth Israel Deaconess Medical Center and Harvard Medical School, who presented her findings at the 33rd annual meeting of the European Society of Human Reproduction and Embryology (ESHRE) in July.

But the success rate changed when looking at men of different ages, with younger men conferring a significant fertility benefit to their partners.

Related:Smartphone App Claims to Accurately Test Male Fertility

Women aged 35-40 did significantly benefit from having a male partner who is under age 30, in that they see a nearly 30% relative improvement in cumulative incidence of live birth when compared to women whose partner is 30-35 from 54% to 70%, said Dodge.

That trend reverses when women in that age group are paired with similar-aged men.

Where we see significant decreases in the cumulative incidence of live birth is among women with male partners in the older age bands. For women age 30-35, having a partner who is older than they are is associated with approximately 11% relative decreases in cumulative incidence of live birth from 70% to 64% when compared to having a male partner within their same age band, explained Dodge.

While the study results add some nuance to the question of mens impact on fertility, the researchers note that women still add the most to the mix.

Both the results of this study and prior work show that female age has a larger effect on fertility than male age. While the effect of female age on fertility is overwhelmingly due to increased rates of chromosomal abnormality, the proposed mechanisms in the effect of male age on pregnancy are more subtle, said Dodge.

When we looked at the effect of female age alone, we saw a 46% relative decrease from ages under 30 to 40-42, but when we looked at male age alone, we saw a 20% relative decrease over the same age span, she added.

The study raises questions about what, if anything, aging men can do to boost conception rates when pairing with younger or same-aged women.

Its hard to say without knowing the precise mechanisms involved, said Dodge. Most preconception advice for men focuses on semen quality, though studies suggest that this likely cannot fully ameliorate the effects of male reproductive ageing. So in the absence of clear evidence of the mechanisms, the best preconception advice we can offer is to maintain a healthy lifestyle.

Related:Old Wives Fertility Treatment Proves to Be Scientific Marvel

Richard Scott is a health care reporter focusing on health policy and public health. Richard keeps tabs on national health trends from his Philadelphia location and is an active member of the Association of Health Care Journalists.

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Tick-Tock: Men Also Have a Biological Clock - - Vital Updates - Vital Updates