‘Grey’s Anatomy’ Fans’ Sex Theory About the Show’s Newest Couple Will Disturb You: Read the Tweets! – Us Weekly

Step down. Greys Anatomy's Thursday, April 6, episodesuggested a potential romance between Maggie Pierce (Kelly McCreary) and Jackson Avery (Jesse Williams), which seemed cute at first until fans had the shocking realization that the two are in fact step-siblings. Also, let's not forget that plenty of fans will forever be on Team Japril, so Jackson and Maggie potentially taking things to a new level was troubling for a number of reasons.

Totally Wrong?

During Thursdays episode, Jackson helped Maggie cope with the loss of her mother by showing her photos the dying woman gave him. You and I are kind of like family, he said.

While the moment seemed touching and super flirty at first, fans were quick to point out that the two characters really are family, as Richard Webber (James Pickens Jr.)is Maggie's biological father and Jackson's stepdad.

Japril Forever

Of course, it also goes without saying that many Grey's fans are diehard Japril supporters who were feeling quite optimistic when Jackson and ex April Kepner (Sarah Drew) finally reconnected at a hotel a few episodes ago. The pair have had their relationship tested multiple times and now have a young child together, so plenty of fans want the couple to finally figure things out.

See what fans had to say on Twitter about the unconventional connection from Thursdays episode.

Tell Us: Do you think Jackson and Maggie will hook up?

Greys Anatomy airs on ABC Thursdays at 8 p.m. ET.

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'Grey's Anatomy' Fans' Sex Theory About the Show's Newest Couple Will Disturb You: Read the Tweets! - Us Weekly

Grey’s Anatomy sneak peek: Will Meredith and Riggs join the mile-high club? – EW.com

Greys Anatomy is trading on-call rooms for airplane bathrooms?

During Thursdays episode of the ABC medical drama, Meredith (Ellen Pompeo) and Riggs (Martin Henderson) are forced to confront their feelings when they are stuck sitting next to each other on a plane. But the duo may also join the mile-high club when Riggs makes his move at an, ahem,inopportune moment. How will Meredith react? Check out theexclusive sneak peek above to find out.

Greys Anatomy airs Thursdays at 8 p.m. ET on ABC.

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Grey's Anatomy sneak peek: Will Meredith and Riggs join the mile-high club? - EW.com

Complex Vascular Anatomy Problematic for Carotid Artery Stenting – MedPage Today

Action Points

Complex aortic arch configurations and internal carotid artery (ICA) tortuosity were bad news for carotid artery stenting, but not endarterectomy, according to an MRI substudy of the International Carotid Stenting Study (ICSS).

New ischemic brain lesions on diffusion-weighted MRI after treatment were found in 51% of cases after stenting and 16% of cases after surgery (OR 6.0, 95% CI 2.9-12.4), the paper in the May 2017 issue of Stroke showed.

With carotid artery stenting, Leo Bonati, MD, of University Hospital Basel in Switzerland, and colleagues found age-independent predictors for new brain lesions to be aortic arch configuration type 2 or 3 (OR 2.8, 95% CI 1.1-7.1) and an ICA angle of 60 or higher (OR 4.1, 95% CI 1.7-10.1).

Those whose largest ICA angle was at least 60 had a 12-fold higher risk of strokes during stenting over their peers with smaller ICA angles (OR 11.8, 95% CI 4.1-34.1).

Complex vascular anatomy was not a factor for strokes during surgery. However, aortic arch configuration types 2 and 3 did trend numerically to a higher risk for cerebral ischemia (OR 3.5, 95% CI 0.7-17.1).

Bonati's group suggested that these configurations are associated with increased atherosclerotic burden or represent markers of general vascular risk. Aortic arch type 2 was defined in the study as having at least 1 supra-aortic artery originating between the outer and inner curvature; aortic arch type 3 was for cases where there was at least 1 supra-aortic artery originated below the level of the inner curvature.

"Older age has consistently been shown a risk factor for procedural stroke in carotid artery stenting, but not in carotid endarterectomy," they wrote. "It has been speculated whether the association might be mediated by vascular anatomy."

"Elongation of the aortic arch and supraaortic arteries was found to be more prevalent in elderly patients, possibly leading to more difficulties during the carotid artery stenting procedure," they concluded. "Notably in our analysis, the associations between ICA angulation and aortic arch configuration with cerebral ischemia in the stenting group remained significant after correction for age. Hence, vascular anatomy should be taken into account when selecting the appropriate treatment option for an individual patient, independent of the patient's age."

The ICSS trial randomized 1,700 patients with symptomatic internal carotid artery stenosis to stenting or surgery. Top-line results put stenting recipients at a disadvantage for adverse events.

For this ICSS substudy, the authors included the 184 patients who got magnetic resonance (n=126) or CT angiography (n=58) at baseline on top of brain MRIs before and after treatment.

Bonati and colleagues posed several reasons why it would make sense that complex vascular anatomy has an association with procedural stroke.

"A complex configuration of the aortic arch and the supraaortic arteries increases the technical difficulty of the stent procedure," they wrote. "Repeated attempts to advance the catheter and guidewire may cause endothelial microtrauma or dislodge atherosclerotic plaque and ultimately cause cerebral emboli."

"The protocol of ICSS did not contain detailed precautions against these complications, such as advice on catheter and guidewire handling, limiting guidewire maneuver time between flushing, syringe aspiration and cleansing, concentration of heparin in saline flush, use of constant infusion via infusion ports to stopcocks, etc.," the authors noted.

"We are therefore unable to verify that all possible precautions against thromboembolism were taken," they wrote. "This limitation must be borne in mind when interpreting the results of our study."

Another limitation is the exclusion of patients with extremely unfavorable anatomy for stenting.

"The fact that the ICSS protocol excluded patients with a stenosis that was thought to be unsuitable for stenting because of proximal tortuous anatomy is likely to have limited the number of patients with very unfavorable anatomy," according to Bonati's group. "The full impact of vascular anatomy on carotid artery stenting risk may therefore have been underestimated in this study."

ICSS was funded by several European government and industry grants.

Bonati disclosed serving on scientific advisory boards for Bayer.

2017-04-13T16:00:00-0400

Excerpt from:
Complex Vascular Anatomy Problematic for Carotid Artery Stenting - MedPage Today

US claims of Syria nerve gas attack: The anatomy of a lie – World Socialist Web Site

By Patrick Martin 13 April 2017

The claims by the US government that the Syrian government carried out a chemical weapons attack on the town of Khan Sheikhun, in southern Idlib province on April 4, have been backed by a week of nonstop media propaganda, as well as uncritical support, across the official political spectrum, for the missile strike ordered by President Trump against a Syrian base.

The charges against the Syrian government are absurd and unbelievable. The campaign mounted by the Trump administration, the intelligence agencies, the Pentagon and the Democratic Party demonstrates complete contempt for the intelligence of the people, and a belief that they can lie with impunity, because nothing they say will be challenged by the servile American media.

No lie is too great. If the US intelligence agencies declared tomorrow that Putin was responsible for an outbreak of tornadoes or a hurricane striking the US Gulf Coast, by means of a secret Russian program to alter the weather, their claims would be presented as the gospel truth by NBC, CBS, ABC, CNN and Fox, while the New York Times would publish a four-page investigative report, complete with maps and charts provided by the CIA.

When a policeman shoots down a working-class youth, it takes months, sometimes years, to complete the investigation. In the case of the Syrian events, it required only minutes for the US government to affix blame and three days to carry out the punishment, firing 59 Tomahawk cruise missiles at a Syrian airbase.

In analyzing a crime, there are three factors to investigate: motive, means and opportunity. In relation to the nerve gas attack on Khan Sheikhoun, neither the Russians nor the Syrians had any reason to carry out the attack. The Assad regime had nothing to gain from the use of nerve gas on a town that was not a significant military target. Moreover, carrying out such an attack would inevitably provoke US military retaliation, something that Assad, on the brink of complete victory in the protracted civil war, would hardly want to risk.

The Syrian rebels and the US government, on the contrary, had motive, means and opportunity. The rebels would view any loss of life as a small price to pay to bring about US intervention in the civil war which they were losing. They have stockpiles of nerve gas and have shown before, in the staged attack on Ghouta in 2013 which killed many more people, a willingness and ability to carry out such a provocation.

Just as importantly, the rebels and their CIA sponsors had opportunity. According to a detailed analysis of the Khan Sheikhoun attack by the respected US physicist and missile expert Theodore Postol, emeritus professor at MIT, the physical evidence strongly suggests that the delivery system for the nerve gas was a mortar shell placed on the ground, not a bomb dropped from a warplane. That means the attack was almost certainly carried out by those who controlled the ground around Khan Sheikhoun, the rebel forces linked to Al Qaeda.

Postols analysis is in reply to the four-page document issued Tuesday by the National Security Council, the White House body that coordinates US foreign and military policy, purporting to prove the Syrian governments responsibility for the alleged sarin gas attack.

The American media described the NSC document as an unusually detailed and factual account, making use of US intelligence material that was declassified for that purpose. The Washington Post said the US government was unveiling intelligence discrediting Russias attempts to shield its ally, Syrian President Bashar al-Assad, from blame in last weeks deadly chemical attack.

The Post went on to characterize the declassified findings as part of a coordinated broadside against Russia that was supplemented by new detail of what U.S. officials believe they know about the chemical weapons strike on Khan Sheikhoun, offered by White House officials who briefed the press on the document.

The New York Times said the document contains declassified United States intelligence on the attack and a rebuttal of Moscows claim that insurgents unleashed the gas to frame the Syrian government. There were similar reports in the Wall Street Journal, the Los Angeles Times, and the television and cable news networks, all of them presenting the intelligence agency accounts as unchallengeable fact.

These media reports are not only demonstrably false, they are absurd. Any serious examination of the NSC document reveals it to be a series of bare assertions without any supporting evidence.

The White House document closely resembles the assessment issued by the US intelligence communitythe 17 agencies that comprise the massive apparatus of spying, political provocation and assassination for American imperialismon alleged Russian interference in the 2016 US presidential election.

It is filled with phrases like The United States is confident We have confidence in our assessment We assess Our information indicates It is clear and so on. In other words, this is the US government speaking, trust us.

There is one reference to signals intelligence, without any elaboration. This is followed by the declaration, standard in all official statements citing information allegedly supplied by the spy agencies: We cannot publicly release all available intelligence on this attack due to the need to protect sources and methods ... Once again, trust us.

The NSC report makes the first attempt by the US government to attribute a motive to the alleged Syrian gas attack, claiming, We assess that Damascus launched this chemical attack in response to an opposition offensive in northern Hamah Province that threatened key infrastructure. Senior regime military leaders were probably involved in planning the attack.

No evidence is cited to back these bare assertions, which raise obvious questions. Why should the Syrian government suddenly resort to sarin gas in a town of no obvious military significance, when it did not use nerve gasand was never accused of doing soduring the critical battles of the past year in Aleppo? Government forces reconquered the rebel-held portions of that city, the countrys largest population and business center before the civil war, in a bloody struggle conducted without the use of chemical weapons.

Even when the forces of President Bashar al-Assad were under attack in his home province of Latakia, where the local population, from the Alawite religious minority which is his main base of support, faced the threat of extermination if the Sunni Islamists were victorious, they did not resort to chemical weapons to beat back the rebel offensive.

The New York Times sought to address this problem by citing senior White House officials, speaking on the condition of anonymity to discuss the declassified intelligence report. These officials asserted that the Syrian government, under pressure from opposition forces around the country and lacking enough troops to respond, used the lethal nerve agent sarin to target rebels who were threatening government-held territory.

This account makes even less sense than the NSC report, since the alleged nerve gas attack did not target rebels who were threatening government-held territory, but civilians in a town in rebel territory, including, as media reporters and Trump administration officials have repeatedly emphasized, large numbers of women and children. In other words, the American media is simply piling lie upon lie, without even taking the time to make the new lies consistent with the old ones.

From a military standpoint, the resort to chemical weapons in Khan Sheikhoun is pointless. From a political standpoint, it is counterproductive, to say the least, for the Assad regime. For the US-backed Islamist rebels, however, such an atrocity is a political goldmine, potentially providing a pretext for US and eventually NATO intervention into a civil war that the rebels are losing badly.

The NSC document makes no attempt to address, let alone rebut, such arguments. Its four-page document includes only one page of supposedly factual findings by the U.S. intelligence agencies, consisting of vague and unsupported assertions, and then a page disputing the claims of Putin and Assad that no gas attack occurred.

In the course of this, the NSC document cites video and eyewitness testimony about the impact of a chemical agent, as well as medical reports from Turkish doctors, but none of this evidence indicates the source of the nerve gas, if it was indeed a factor in the deaths at Khan Sheikhoun.

Criticizing Russian claims of fabrication, the NSC document declares, It is clear, however, that the Syrian opposition could not manufacture this quantity and variety of video and other reporting from both the attack site and medical facilities in Syria and Turkey while deceiving both media observers and intelligence agencies.

Why should anyone believe that the media observers and intelligence agencies were among the deceived? Far more likely that the US intelligence agencies and the media observers, particularly those employed by the New York Times, Washington Post, and other conduits for the US government, were active participants in the deception.

The CIA has ample experience in the creation of provocations and fabrication of evidence, which is then supplied to its favored press outlets to create the impression of objective reporting. Absolutely nothing that is reported on such a basis deserves the slightest credibility.

It is noteworthy that the Russian government has repeatedly called for an objective, authoritative international investigation into what happened at Khan Sheikhoun. This is in sharp contrast to the conduct of the Trump administration, which has acted as judge, jury and executioner rolled into oneclaiming to determine the facts, identify the perpetrators and carry out the punishment in a three-day period. This is the method, not of justice or the enforcement of international law, but the law of the jungle, in which the most powerful imperialist military power simply does what it wants.

There is every reason to believe that the poison gas attack on Khan Sheikhoun was staged by the CIA and its rebel stooges to force a reversal of policy by the Trump administration and pave the way for US military intervention. It follows the pattern of the last previous alleged chemical weapons attack, in August 2013, when the rebels were seeking to gain direct American support, and US Secretary of State John Kerry told them that something needed to happen. Soon after, more than a thousand people were killed by nerve gas in Ghouta, a rebel-held suburb of Damascus.

The political beneficiaries of this attack were the Syrian rebels. Seymour Hersh, one of a handful of real journalists still practicing his profession and not in jail or exile, conducted a meticulous exposure of the Ghouta attack, demonstrating that it had likely been carried out by the al-Nusra Front, the Al Qaeda affiliate in Syria, with chemical weapons supplied by Turkey. The al-Nusra Front, under a new name, is the dominant force on the ground today in Khan Sheikhoun.

The Ghouta attack did not have the expected effect. After the British parliament voted against joining an attack on Syria, and in view of sharp divisions within the Pentagon over whether to intervene, President Obama pulled back, to the enormous frustration of the CIA, and of leading Democrats like his former secretary of state, Hillary Clinton.

If Clinton had won the 2016 presidential election, there is no doubt there would have been an immediate and dramatic escalation in the American involvement in the Syrian civil war. Following Trumps surprise victory, a ferocious conflict has ensued, centering on bogus allegations of Russian manipulation of the election to assist Trump, aimed at shifting the Trump administrations policy towards Russia and Syria.

This has now culminated in the apparent victory of the US intelligence agencies and the Democrats in this internecine struggle within the US ruling elite, and Trumps embarking on a course that threatens to produce full-scale US military intervention in the Syrian civil war, and poses the danger of direct confrontation with a nuclear-armed Russia.

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US claims of Syria nerve gas attack: The anatomy of a lie - World Socialist Web Site

Anatomy of a Sarin Bomb Explosion (Part I) – bellingcat

Part I: The Bomb, its contents, and their likely fate

The recent chemical attack inKhan Shaykhun in Syria is alleged by witnesses to have been delivered by an air-dropped bomb. The purpose of this article is to systematically break down a Sarin bomb into its components and analyse what happens to them. This first part addresses the contents of the bomb and how these components interact with the environment.

Whats in an air-dropped Sarin bomb? A Sarin bomb will contain more than just Sarin.

Sarin. The nerve agent Sarin will be in liquid form. However, no chemical reaction makes pure Sarin and no weapon system known to date contained just pure Sarin. Other things are likely to be present in some percentage. They are listed below.

Unreacted Components: It is highly unlikely that any Sarin binary mixing done before loading will be absolutely 100% effective. Bits of unreacted binary components that werent mixed properly, i.e. methylphosphonyl difluoride (DF) and isopropyl alcohol

Hydrogen fluoride (HF) : This results from the DF + isopropyl alcohol reaction. Also results from DF reacting with water. Byproducts: chemicals that are formed by improper DF + alcohol reactions, or are left over in the DF as impurities from earlier stages of production. Degradation products : Sarin, unless made properly, degrades quickly. And Sarin degrades in the presence of moisture. Degradation products are chemicals that result from degradation of the Sarin, such as isopropyl methylphosphonic acid, which in turn degrades to methylphosphonic acid. Additives: Anything additional added, such as acid scavengers and anti-corrosion inhibitors, e.g. hexamine, tributylamine, etc. Also, as some additives are designed to react with the residual HF, the presence of these compounds, e.g. salts, may be present.

Fuze and Bursting charge: Explosive material to make the bomb burst open and create an aerosol. This would include the whole firing chain, with fuzing and several different explosive materials, as well as wiring.

Case material: This is the body of the bomb, including coatings and linings.

Design and Intent of the weapon

US Weteye Sarin Bomb

Non-persistent nerve agents, such as Sarin are used for immediate production of casualties, as their ability to produce contamination is time-limited. As such, Sarin weapons generally function on the principle of producing as much aerosol (a finely divided mist of droplets) as possible. Persistent nerve agents, such as VX, are designed to contaminate terrain and equipment, and cause immediate casualties primarily by skin contact. Therefore, they are often designed to cause dispersal of larger droplets.

How big an explosive charge?

The necessary charge to agent ratio is needed to ensure proper dissemination of the chemical agent contents. A bursting charge that is too small means that too little aerosol is created and you end up with a large pool of liquid or large splashes of Sarin extremely deadly in the immediate vicinity, but not good for causing casualties over a wide area. If the bomb uses too much explosive, much or all of the Sarin is destroyed. Sarin decomposes at higher temperatures. At its boiling point, around 150 deg C, it decomposes rapidly. A large amount of high explosives would easily heat much of the Sarin in a bomb to 150 deg C.

The thickness and structural integrity of the case of the bomb is a key factor in the size of the burster charge, and one of the reasons why air-dropped bombs have a higher ratio of chemical agent to explosive than artillery shells, which, comparatively, have a thicker case. Data on charge to agent ratios for air-dropped bombs is rare, but some information from the old US chemical arsenal has now seeped into the public domain. These charge to agent ratios were fine tuned with extensive field testing at proving grounds and resulted in optimum formation of aerosol. For example, the MC-1 Sarin bomb contained 100kg of Sarin and had a burster charge weighing 6.8 kg, although not all of the 6.8 kg will be explosive weight, i.e. some of that weight will be wire and casing. The US Mk94 bomb held 49kg of Sarin and had a 7.3 kg burster. The Weteye bomb appears to have contained 159 kg of Sarin and had a large bursting charge, around 27 kg, leading one to deduce that it had a much thicker case. I can find no comparable statistics for USSR-produced systems.

Air-burst versus ground burst

Ever since the development of chemical bombs and artillery shells early in the 20th century, the general consensus among chemical weapons experts is that non-persistent agents are detonated at or near ground level, whereas persistent agents, whose primary purpose is contamination of terrain and equipment, are detonated as air bursts. Non-persistent agents are designed with production of casualties in mind and keeping the aerosol at or near ground level helps to maintain a higher concentration of the chemical agent than detonating in the air. The latter serves to dilute the concentration a little or a lot, depending on local conditions. With persistent agents, the idea is to have a wider radius of dispersal of droplets to cause contamination of terrain and equipment. The air-dropped bombs for delivering Sarin developed in the US in the Cold War were all impact fuzed for ground burst.

US MC-1 Sarin Bomb

What happens when the Sarin bomb is dropped

The following chain of events happens when a typical Sarin bomb is dropped in an air strike:

This chain of events causes dispersal The Sarin inside the bomb will end up dispersed in a number of ways simultaneously.

The distribution of the Sarin into these categories will vary heavily based on the design of the weapon and a little bit from local factors, such as weather conditions and the type of surface the bomb hits. For example a bomb dropped into a swamp will behave differently to one dropped onto dry land.

The eventual fate of these dispersed bits of Sarin will vary according to the categories above. Lets examine what happens to each category:

Part II Coming soon. How the Sarin bomb and its contents will interact with its victims. This will address the key issues of how Sarin enters the human body and how and why responders were seen handling victims with relatively little protective equipment.

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Anatomy of a Sarin Bomb Explosion (Part I) - bellingcat

RIP to RISP: Anatomy of an At Bat – Waiting For Next Year

The Cleveland Indians (4-4) continue to sputter when it comes to scoring runs as they lost on Tuesday to the Chicago White Sox (3-4), 2-1. Starting pitcher Danny Salazar had a rough start to the game but managed to close strong with an effort that deserved better (6.0 IP, 4 H, 2 ER, 2 BB, 11 K, 106 pitches). Boone Logan, Dan Otero, and Zach McAllister continued the early season dominance from the bullpen with three shutout innings.

The expected offensive fireworks from the Indians have thus far been muted. The Tribe is now 0-for-18 with runners in scoring position (RISP) in their home opening series. Overall, the team is hitting 8-for-61 with 11 walks and 21 strikeouts as they have split the initial two games against the White Sox (.131 batting average, .222 on base percentage). The only run on Wednesday coming on a weak grounding fielders choice to first.

One of the struggling bats has been the prize free agent signee, Edwin Encarnacion. He is a meager 5-for-29 with 12 strikeouts though he does have a double and home run among his few hits (.172/.273/.310). The cleanup hitter has also come up empty when there are runners to knock in as he is now 0-for-7 with two walks with RISP. Tuesdays game was a personal nightmare for Encarnacion as he twice grounded into inning ending double plays with bases loaded and one out. Michael Brantleys 10th inning walk-off heroics bailed him out.

Wednesday would offer a chance for redemption when Lindor stood on third base with the Indians down by a single run in the eighth inning and only one out. A deep sacrifice fly would suffice. Encarnacion struck out, and the last threat would end with a Jose Ramirez ground out.

There is no reason to panic about the slow start, but it is instructive to break down Encarnacions latest RISP opportunity. Here is that at bat in detail.

First Pitch: Foul, 0-1

The at bat was almost over on the first pitch. Reliever Nate Jones left an 89 mile per hour slider hang belt-high over the meat of the plate. Encarnacion took a strong swing and sent it for a ride, but his timing was a bit off as he sliced it foul.

Second Pitch: Ball, 1-1

Lindor was almost able to score again as Jones not only threw a slider in the dirt but well into the left-handed batters box. A fantastic effort by catcher Omar Narvaez of not only blocking it but keeping the ball in front of him was required to keep Lindor on third base.

Third Pitch: Whiff, 1-2

Jones sticks with the slider as his arsenal is almost exclusively sliders and a two-seam fastball that has much more velocity than sinking action. With Encarnacion a fastball hitter, the White Sox have elected to stay away from those similar to the Indians gameplan against him in the 2016 ALCS. The third offering from Jones had better late dropping action compared to his other pitches, which had Encarnacion swinging through air for the whiff.

Fourth Pitch: Foul, 1-2

For the third time in four pitches, Encarnacion almost finds a way to get the job done. Poor luck is encapsulating this plate appearance. Another slider, another belt-high job with no break just like the first pitch. Unlike the first foul ball, mere inches separate this batted ball from finding fair territory. First baseman Jose Abreu gave chase but was not going to catch up to it. The slice was barely enough to stop the Indians from tying the game.

Fifth Pitch: Ball, 2-2

For the only time in this at bat, Jones threw his two-seam fastball. He pitched it belly high in an attempt to entice Encarnacion to swing, but the patient hitter saw it traveling far outside the strike zone.

Sixth Pitch: Whiff, Strikeout

The previous ball might have been a mere setup for the closing pitch. Jones started the path of this pitch on a similar plane to his fifth pitch two-seamer. However, he went back to the slider and got fantastic breaking action from it. There was an initial appearance that it would come back over the plate and Encarnacion (in protection mode with two strikes) committed to his swing. Unfortunately, Jones was able to obtain vertical drop on this offering late, which ended the break towards the plate and made Encarnacion whiff at air to complete the strikeout.

Last Word The 2017 MLB season is still in its infancy. Past Terry Francona Cleveland ballclubs have struggled out of the gate as he has yet to finish an April with a winning record. He has yet to finish a season in Cleveland with a losing record. Encarnacion has also had his share of April struggles as he slashed .239/.303/.394 in April from 2014-2016. He has finished those seasons at .269/.361/.544. The weather will warm, and the bats will warm with it. Until then, the Indians will need to continue to find ways to scrape out wins so that they are in position to trampoline over division rivals who have been surprisingly competitive in the incredibly early stages of the season.

Continued here:
RIP to RISP: Anatomy of an At Bat - Waiting For Next Year

Genetics of first-cousin marriage families show how some are protected from heart disease – Medical Xpress

April 12, 2017 A depiction of the double helical structure of DNA. Its four coding units (A, T, C, G) are color-coded in pink, orange, purple and yellow. Credit: NHGRI

More than 1,800 individuals carrying loss-of-function mutations in both copies of their genes, so-called "human knockouts," are described in the first major study to be published in Nature this week by an international collaboration led by the Perelman School of Medicine at the University of Pennsylvania and colleagues. The program, which has so far sequenced the protein-coding regions of over 10,500 adults living in Pakistan, is illuminating the basic biology and possible therapeutics for several different disorders.

The team has identified more than 1,300 genes completely knocked out in at least one individual. They first turned their attention for deeper analysis to genes involved in cardiovascular and metabolic diseases. One gene in particular, APOC3, which regulates the metabolism of triglyceride-rich lipoproteins in the blood, was missing in several dozen individuals in a small fishing village on the coast of Pakistan where first-cousin marriages are culturally prevalent. These APOC3-knockout individuals had very low triglyceride levels. The researchers challenged their system with a high-fat meal. Compared with family members who were not APOC3 knockouts, the APOC3 knockout family members did not have the usual post-meal rise in plasma triglycerides.

"These are the world's first APOC3 human knockouts that have been identified," said co-first author and the principal investigator of the study, Danish Saleheen, MD, PhD, an assistant professor of Epidemiology and Biostatistics at Penn. "Their genetic makeup has provided unique insights about the biology of APOC3, which may further help in validating APOC3 inhibition as a therapeutic target for cardiometabolic diseases - the leading cause of death globally.

In addition to Penn, the team includes scientists from the Center for Non-Communicable Diseases (CNCD) in Karachi, Pakistan, the Broad Institute of MIT and Harvard, and the University of Cambridge, UK.

Saleheen has been working for over a decade in Pakistan, in collaboration with the CNCD to collect blood samples from all over his country. This Pakistan-based study already includes more than 70,000 participants and the recruitment is rapidly being expanded to include 200,000 people. "We are continuing protein-coding region sequencing studies in the Pakistani population. If we are able to sequence 200,000 participants, we will be able to identify human knockouts for more than 8,000 unique genes." Saleheen said. "These observations provide us with a roadmap, a systematic way to understand the physiological consequences of complete disruption of genes in humans," Saleheen said.

"The Human Genome Project gave us a 'parts' list of 18,000 genes. We are now trying to understand gene function by studying people who naturally lack a 'part,'" said co-senior author Sekar Kathiresan, Director of the Center for Genomic Medicine at Massachusetts General Hospital. "We think that over the next ten to twenty years, with a concerted, systematic effort, it's possible to find humans who naturally lack any one of several thousand genes in the genome and understand what the phenotypic consequences are."

"The project highlights the value of looking at diverse populations, particularly for genetic analysesyou'll find variants in one ethnicity and not another," said co-first author Pradeep Natarajan, an associate scientist at Broad Institute and a postdoctoral research fellow in Kathiresan's lab.

Co-senior author Daniel J. Rader, MD, chair of Genetics at Penn, hopes that future dives into this rich dataset will bring even more novel insights into human biology and point toward new therapeutic targets for treating and preventing disease. "Linking DNA sequencing with deep phenotyping at scale in this population will be an incredible source of new knowledge about how gene alterations influence human health and disease," Rader said. In addition to a continued focus on the biology of heart attacks, type 2 diabetes, and stroke, the team will also be looking for clues for early-onset Parkinson's disease, autism, congenital blindness, and mental retardation, among many other conditions.

Penn scientists are now collaborating with CNCD researchers to conduct deep phenotyping studies in all human knockouts the project identifies. These studies will include detailed physiological and mechanistic studies to understand the biological and pharmacological consequences of both partial and complete disruption of genes in humans.

Explore further: Study reveals the effect of genetic 'knockouts' on human health

More information: Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity, Nature (2017). nature.com/articles/doi:10.1038/nature22034

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A big data study of hepatitis C and more than 500 patients with the virus has opened the way for a better understanding of how the virus interacts with its human hosts.

Scientists at The Wistar Institute have unveiled part of the protein complex that protects telomeresthe ends of our chromosomes. The study, published online in Nature Communications, explains how a group of genetic mutations ...

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Genetics of first-cousin marriage families show how some are protected from heart disease - Medical Xpress

James Rothman appointed Sterling Professor of Cell Biology – Yale News

James E. Rothman, newly appointed as a Sterling Professor of Cell Biology, is one of the world's most distinguished biochemists and cell biologists. For his work on how molecular messages are transmitted inside and outside of human cells, he was awarded a Nobel Prize in 2013.

A Sterling Professorship is one of the universitys highest faculty honors.

Rothman helped reveal the mechanism that allows cellular compartments called vesicles to transmit information both in the interior of the cell and to the surrounding environment. The fusion of vesicles and cellular membranes, a process called exocytosis, is basic to life and occurs in organisms as diverse as yeast and humans. Exocytosis underlies physiological functions ranging from the secretion of insulin to the regulation of the brain neurotransmitters responsible for movement, perception, memory, and mood.

Rothmans current research concerns the biophysics of membrane fusion and its regulation in exocytosis; the dynamics of the Golgi apparatus at super-resolution; and the use of bio-inspired design in nanotechnology.

After graduating from Yale College with a degree in physics, Rothman earned a Ph.D. in biological chemistry from Harvard Medical School. He conducted postdoctoral research at the Massachusetts Institute of Technology before moving to the Stanford School of Medicine as an assistant professor. He continued his research at Princeton University, where he became the founding chair of the Department of Cellular Biochemistry and Biophysics at Memorial Sloan-Kettering Cancer Center and vice chair of the Sloan-Kettering Institute. Prior to coming to Yale in 2008, Rothman served on the faculty of Columbia Universitys College of Physicians and Surgeons, where he was a professor in the Department of Physiology and Biophysics, the Clyde and Helen Wu Professor of Chemical Biology, and director of the Columbia Genome Center.

Rothman serves as chair of the Yale School of Medicines Department of Cell Biology and as director of the Nanobiology Institute on Yales West Campus.

He has received numerous awards and honors in recognition of his work on vesicle trafficking and membrane fusion, including the King Faisal International Prize for Science, the Gairdner Foundation International Award, the Lounsbery Award of the National Academy of Sciences, the Heineken Foundation Prize of the Netherlands Academy of Sciences, the Louisa Gross Horwitz Prize of Columbia University, the Lasker Basic Science Award, the Kavli Prize in Neuroscience, the Massry Prize, and the E.B. Wilson Medal. He is a member of the National Academy of Sciences and its Institute of Medicine, and is a fellow of the American Academy of Arts and Sciences.

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James Rothman appointed Sterling Professor of Cell Biology - Yale News

Mayor’s attorney: Murray’s anatomy disproves sex abuse claim – seattlepi.com

'This is the heart of the allegations, and they are false'

By Daniel DeMay, SeattlePI

Seattle Mayor Ed Murray's attorney said Tuesday that a recent medical exam contradicts claims made about the mayor's anatomy by a man who says Murray sexually abused him as a boy.

Responding to a detailed description offered in the sex abuse lawsuit, Murray's personal attorney Robert Sulkin said Tuesday that a doctor examined Murray and found no evidence of the mole described as being on his scrotum in the lawsuit. Sulkin said the doctor's report also found no evidence that any mole was removed from the area.

"This is game changing," Sulkin said. "This is the heart of the allegations, and they are false. ...

"If you think about it, the accuser provided false information to his own lawyers. ... The case should be dropped."

Photo: GENNA MARTIN/SEATTLEPI.COM

Seattle Mayor Ed Murray speaks at a press conference Friday, April 7, 2017, called to address new claims that he sexually abused a teen boy in the 1980s. He denied the claims and said he would continue to serve as mayor and seek another term.

Seattle Mayor Ed Murray speaks at a press conference Friday, April 7, 2017, called to address new claims that he sexually abused a teen boy in the 1980s. He denied the claims and said he would continue to serve

Attorney Bob Sulkin presents new information on sex-abuse allegations against Seattle mayor Ed Murray following a medical exam of Murray, at McNaul Ebel Nawrot & Helgren on Tuesday, April 11, 2017.

Attorney Bob Sulkin presents new information on sex-abuse allegations against Seattle mayor Ed Murray following a medical exam of Murray, at McNaul Ebel Nawrot & Helgren on Tuesday, April 11, 2017.

Attorney Bob Sulkin presents new information on sex-abuse allegations against Seattle mayor Ed Murray following a medical exam of Murray, at McNaul Ebel Nawrot & Helgren on Tuesday, April 11, 2017.

Attorney Bob Sulkin presents new information on sex-abuse allegations against Seattle mayor Ed Murray following a medical exam of Murray, at McNaul Ebel Nawrot & Helgren on Tuesday, April 11, 2017.

Attorney Bob Sulkin presents new information on sex-abuse allegations against Seattle mayor Ed Murray following a medical exam of Murray, at McNaul Ebel Nawrot & Helgren on Tuesday, April 11, 2017.

Attorney Bob Sulkin presents new information on sex-abuse allegations against Seattle mayor Ed Murray following a medical exam of Murray, at McNaul Ebel Nawrot & Helgren on Tuesday, April 11, 2017.

Seattle Mayor Ed Murray arrives at a press conference Friday, April 7, 2017, called to address new claims that he sexually abused a teen boy in the 1980s. He denied the claims and said he would continue to serve as mayor and seek another term.

Seattle Mayor Ed Murray arrives at a press conference Friday, April 7, 2017, called to address new claims that he sexually abused a teen boy in the 1980s. He denied the claims and said he would continue to

Mayor's attorney: Murray's anatomy disproves sex abuse claim

A Seattle-area man filed the lawsuit last week claiming Murray had paid him for sex at least 50 times over the course of several years in the 1980s, starting when the man was just 15 years old.

Last Thursday, Murray's personal spokesperson and then his personal attorney both claimed the suit was politically motivated as Murray, a Democrat with a long history in public office, is seeking his second mayoral term this year.

Murray made a statement in person Friday, telling reporters he has no intention of resigning or ending his bid for reelection.

Attorneys for the man bringing the suit issued a statement following Sulkin's news conference, saying Murray's attorney had not responded to offers to depose the man, who went by D.H. in the suit, within the week.

"Instead, the Mayor's team hired their own medical witness to look at the Mayor's private parts and declared that which nobody in the public can verify until long after the election filing deadline of May 19," attorneys wrote in the statement. "We look forward to fighting the merits of this lawsuit in the appropriate venue and exploring the need for an independent medical exam as ordered by the court."

Sulkin said the mayor would submit to such an exam if ordered by a judge.

In the suit, D.H. included specific details about Murray's apartment at the time, his phone number and his genitals.

Specifically, he described a "unique mole" on Murray's scrotum in the complaint.

Sulkin said Tuesday the mole was like the fingerprint of the case.

"This is why it was put in (the suit) and it's false," he said.

In the story first reported by The Seattle Times, two other men were interviewed who had previously made similar claims to those detailed by D.H. in the suit. At the time those claims were made -- 2007 and 2008 -- one man began working on a suit, but his lawyer ultimately dropped the case. The man called various media and other lawmakers (Murray was in the state Senate at the time), but the Times and other media didn't report on the story, according to the Times report.

Sulkin called out the Times for "rushing" the story before giving Murray a chance to debunk the claims.

----------

Senior editor Levi Pulkkinen contributed to this report

Daniel DeMay covers Seattle culture, business and transportation for seattlepi.com. He can be reached at 206-448-8362 ordanieldemay@seattlepi.com.Follow him on Twitter:@Daniel_DeMay.

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Mayor's attorney: Murray's anatomy disproves sex abuse claim - seattlepi.com

Jo From ‘Grey’s Anatomy’ Gave Birth To First Child And Picked The Perfect Name – Elite Daily

Camilla Luddington has officially joined the club of Greys Anatomy stars who have children. (Its a very specific club, OK?)

The actress who has played Jo Wilson on the last five seasons of the show gave birth to her first child, a baby girl.

Luddington announced the news on Tuesday with a sweet Instagram video of herself, her new daughter and her daughters father, actor Matt Alan.

Luddington also revealed her babys name in the post which is drumroll please HAYDEN!

She wrote in the caption,

We have a new great love in our lives our sweet baby girlHayden

Isnt that just the perfect name?

Jo Wilson fans might have been hoping for a Greys Anatomy name like Josephine or Meredith, but oh well.

But I do have a fun little bit of trivia for diehardShondaland residents: There actuallyis a Hayden in Greys Anatomy. Sort of.

In Season 9, Episode 21, Sleeping Monster, Cristina Yang is reading a book called Haydens Progress.

A little bit of googlingtells me that no such book actually exists. So what is this mysterious, fake book that the set department came up with for the show?

Could it possibly have something to do withCamilla Luddington, who had just joined the show as Jo that season?

I mean, no, probably not. Its almost definitely a coincidence. But still, its fun to speculate.

Luddington and Alanannounced theirpregnancy back in October. Though they are dating, the coupleare not married.

Alan is also an actor, and recently appeared as Seth in three episodes of the Netflix original series, 13 Reasons Why.

Luddington got a little present from the Greys Anatomy team in light of her baby news, which she also posted about on Instagram, writing in the caption, When the #greysanatomy wardrobe Dept give you a baby gift.

The baby onesie reads,

I know Jos real name, but I dont know how to talk yet.

So I guess the real question is, which Shondaland resident knows how to speak baby?

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Anna Menta is a Entertainment Writer at Elite Daily. Previously she has been a BuzzFeed Editorial Fellow, and an annoying film student at Oberlin College. She apologizes if she says something weird to you. Follow her on Twitter @annalikestweets ...

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Jo From 'Grey's Anatomy' Gave Birth To First Child And Picked The Perfect Name - Elite Daily