People who think about this stuff don’t think bad online behavior will get better any time soon – Nieman Journalism Lab at Harvard

The quality of public discourse online is not going to get better and may actually get worse over the next decade, according to a survey released Wednesday by the Pew Research Center that invited 8,000 technology experts, scholars, corporate practitioners and government leaders to respond.

Forty-two percent of the 1,537 participants said they anticipate no major change in levels of online trolling and other harmful behavior that is found online. Another 39 percent said the next decade will be more shaped by these types of online behaviors.

While respondents expressed a range of opinions from deep concern to disappointment to resignation to optimism, most agreed that people at their best and their worst are empowered by networked communication technologies, the studys authors wrote. Some said the flame wars and strategic manipulation of the zeitgeist might just be getting started if technological and human solutions are not put in place to bolster diverse civil discourse.

Pew and Elon Universitys Imagining the Internet Center conducted the survey between July 1 and August 12, 2016, before the height of the divisive U.S. election.

The report categorizes responses into four primary themes that outline what the future of online discourse might hold:

Many respondents think things will just get worse as humans continue to evolve to a relatively new medium.

I would very much love to believe that discourse will improve over the next decade, but I fear the forces making it worse havent played out at all yet, technology consultant Jerry Michalski said. After all, it took us almost 70 years to mandate seatbelts. And were not uniformly wise about how to conduct dependable online conversations, never mind debates on difficult subjects. In that long arc of history that bends toward justice, particularly given our accelerated times, I do think we figure this out. But not within the decade.

We see a dark current of people who equate free speech with the right to say anything, even hate speech, even speech that does not sync with respected research findings, an anonymous MIT professor said. They find in unmediated technology a place where their opinions can have a multiplier effect, where they become the elites.

The social media ecosystem is attention-driven; the platforms themselves make money from advertising and, as a result, want to continue to drive participation. And because the platforms are so crowded, its often the loudest voices that get the most attention, which carries over into our larger political debates.

Distrust and trolling is happening at the highest levels of political debate, and the lowest, said researcher Kate Crawford. The Overton Window has been widened considerably by the 2016 U.S. presidential campaign, and not in a good way. We have heard presidential candidates speak of banning Muslims from entering the country, asking foreign powers to hack former White House officials, retweeting neo-Nazis. Trolling is a mainstream form of political discourse.

And as social medias influence has grown, traditional media outlets have seen their influence wane. Heres how Steven Waldman, the founder and CEO of LifePosts, explained it:

It certainly sounds noble to say the internet has democratized public opinion. But its now clear: It has given voice to those who had been voiceless because they were oppressed minorities and to those who were voiceless because they are crackpots. It may not necessarily be bad actors i.e., racists, misogynists, etc. who win the day, but I do fear it will be the more strident.

Some respondents were more optimistic that the levels of online discourse would improve over the next decade. Artificial intelligence and other technological improvements will help improve dialogue, some said.

I expect we will develop more social bots and algorithmic filters that would weed out the some of the trolls and hateful speech, Marina Gorbis, executive director of the Institute for the Future, said. I expect we will create bots that would promote beneficial connections and potentially insert context-specific data/facts/stories that would benefit more positive discourse. Of course, any filters and algorithms will create issues around what is being filtered out and what values are embedded in algorithms.

Additionally, as platforms become more influenced by algorithms, respondents expect to see continued fragmentation of the online ecosystem.

There will still be some places where you can find those with whom to argue, but they will be more concentrated into only a few locations than they are now, senior design researcher Lindsay Kenzig said.

Respondents also expressed concern that increased regulation of online spaces could result in surveillance and censorship. They also worried that people would begin to change their positive online behaviors as surveillance increase.

Rebecca MacKinnon, director of the Ranking Digital Rights project at the New America foundation, said shes worried about the state of free speech online:

The demands for governments and companies to censor and monitor internet users are coming from an increasingly diverse set of actors with very legitimate concerns about safety and security, as well as concerns about whether civil discourse is becoming so poisoned as to make rational governance based on actual facts impossible. Im increasingly inclined to think that the solutions, if they ever come about, will be human/social/political/cultural and not technical.

Queensland University of Technology professor Marcus Foth warned that the increased regulation of online speech could result in polarization and filter bubbles:

With less anonymity and less diversity, the two biggest problems of the Web 1.0 era have been solved from a commercial perspective: fewer trolls who can hide behind anonymity. Yet what are we losing in the process? Algorithmic culture creates filter bubbles, which risk an opinion polarization inside echo chambers.

The full report, in which you are certain to find at least one opinion you agree with, s available here.

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People who think about this stuff don't think bad online behavior will get better any time soon - Nieman Journalism Lab at Harvard

Evidence Indicates That Universal Basic Income Improves Human Health – Futurism

In BriefThe immediate need for basic income in recognition of theeffects of chronic stress and the importance of improvingenvironments. Eliminating huge stressors like worrying about beingable to afford food and shelter can do wonders for the potential ofhumanity. Biological Case for UBI

At the end of 2015, after a year-long journey, I achieved the realization of an idea with the help of about 140 people that has already forever changed the way I look at the very foundations or lack thereof upon which all of society is based. I now firmly believe we have the potential through its universal adoption to systemically transform society for the better, even more so than many of those most familiar with the idea have long postulatedbecause, for me, the idea is no longer just an idea. Its not theory. It is part of my life. Its real. And the effects are undeniable for someone actually living with it.

The idea of which I speak goes by the name of basic income but is best understood not by name, but by function, and that function is simply to provide a monthly universal starting point located above the poverty line as a new secure foundation for existence. Its an irrevocable stipend for life. In the U.S. it would be something like $1,000 for every citizen every month. All other income would then be earned as additional income on top of it so that employment would always pay more than unemployment.

This may sound overly expensive, but it would save far more than it costs. It would also really only require an additional net transfer of around $900 billion, and thats without subtracting the existing welfare programs it could replace, and also without simplifying the tax code through the replacement of all the many credits, deductions, and subsidies it could also replace. Basically, were already handing out money to everyone, rich and poor alike, but in hundreds of different ways through thousands of government middlemen who only serve to disincentivize employment by removing government supports as a reward for working.

Odds are this idea is new to you, but its not a new idea. Its been considered for hundreds of years from as long ago in the U.S. by founding father Thomas Paine in the 18th century, to Richard Nixon, Martin Luther King, Jr., and free market-loving Milton Friedman in the 20th century, to a quickly growing list of new names here in the 21st century. Its advocates know no ideological lines. Supporters include Nobel prize-winning economists, libertarians, progressives, conservatives, climate change activists, tax reformers, feminists, anarchists, doctors, human rights defenders, racial justice leaders, and the list goes on.

For such an old idea thats been endorsed by so many for so long and yet has obviously never yet come to be, you may be thinking, Why now? The answer to such a question has economic reasoning rooted in the globalization of labor and the exponential advancement of technologies capable of entirely replacing labor, but as important as this particular discussion is to have, its centered more around the idea of a future problem and less a present one.

However, our problems are very much in the present and to see why, we need to go deeper, much deeper, beyond technology and economics, and into human biology itself. To do that, well first need to look at what we as humans have learned from some animals in the lab and in the wild, because I think doing so pulls back the curtain on our entire social system.

As is true with many scientific discoveries, they tend to be accidental, and the story of Martin Seligman and some dogs back in 1965 is no different. Seligman wanted to know if dogs could be classically conditioned to react to bells in the same way as if theyd just been shocked, so he put them in a crate with a floor that could be electrified, and shocked them each time he rang a bell. The dogs soon began to react to the bell as if theyd just been shocked. Next however, he put them in a special crate where they could leap to safety to avoid the shock, and this is where the surprise happened.

The dogs wouldnt leap to safety. It turns out theyd learned from the prior part of the experiment that it didnt matter what they did. The shock would come anyway. They had learned helplessness. Seligman then tried the experiment with dogs who had not been shocked and they leaped to safety just as expected. But the dogs who had learned helplessness, they just sadly laid down and whimpered.

Fast forward to 1971 where a scientist named Jay Weiss explored this further with rats in cages. He put three rats into three different cages with electrodes attached to their tails and a wheel for each to turn. One rat was the lucky rat. No shocks were involved. Another would get shocks that could be stopped by turning its wheel. The third was the unlucky one. It would get shocked at the same time as the second rat, but it could do nothing about it. The third rat would only stop getting shocked when the second rat turned its wheel. Can you guess what happened?

Even though the two rats that were shocked got shocked at the same time and for the same duration of time, their outcomes were very different. The rat who had the power to stop the pain was just a bit worse off than the rat who experienced no pain at all. However, the rat who had no control whatsoever, stuck with a lever that did nothing, became heavily ulcerated. Like the dog, it too had learned helplessness. The cost of this lesson was its health.

Of course, humans are not dogs or rats. Theres a bit more complexity when it comes to us and our physiological responses. For us, perception is a key factor. This is where something called attribution comes into play, of which there are three important kinds that lead to humans learning helplessness: internal, stable, and global.

Think back to when you first started school and try to remember your first math test. What if after taking that first test you did poorly on it, and instead of all the other possible reasons for why that could happen, you decided it was because you sucked at math? Thats an internal attribution. Now imagine you applied that attribution to all math tests. Thats a stable attribution. Its not a one-time thing. Now imagine you applied it beyond math to all classes. Thats a global attribution. Consider the results of such perceptions.

Maybe that first math test was simply too hard for everyone in the class. Maybe it wasnt just you. Maybe your poor grade was due to not studying hard enough, or because you were too hungry or too tired. But instead, because you decided it was your fault and it meant you were stupid, your entire life went down a different path. Even though at any point along the way, you could have escaped that path, just like Seligmans dogs could have escaped the shocks, what if you had learned helplessness from that first math test?

We can learn to be helpless in an environment that actually offers us control, and the feeling itself of control can be the difference between a life full of unending stress, and a relatively stress-free life.

Its even been shown that we only need to be told theres nothing we can do in order for us to feel theres no point in trying. Its like a self-fulfilling prophecy. Tell everyone theres no point in voting, and fewer people will vote.

What all of this shows is two-fold and extremely important to remember. We can learn to be helpless in an environment that actually offers us control, and the feeling itself of control can be the difference between a life full of unending stress, and a relatively stress-free life.

Stress is more than a feeling. Stress is a physiological response, and it has important evolutionary reasons for being. Back in the day, many thousands of years ago, our ancestors who could shift into a kind of emergency gear where long-term higher-order creative thinking shut down, and the body was enabled to think faster, react quicker, be stronger, move faster, run longer, and think only about survival those were the humans who survived.

We call this now the fight-or-flight response, and where this once incredibly important response was evolutionarily adaptive, it is now maladaptive. We dont live in that same world anymore where it made so much sense. We arent being chased down by lions or being eaten by wolves while sitting in front of our computers in our air-conditioned offices, and yet our fight-or-flight responses are still being activated. In fact, for far too many, daily existence is nothing but fight-or-flight. Long-term stress is a real problem, and I would argue, its not just a health problem. Its a problem for human civilization.

One of the most knowledgeable scientists in the world in this area is Robert Sapolsky, a pioneering neuroendocrinologist and professor at Stanford University who has spent more than thirty years studying the effects of stress on health, of which there are many. Over the years, Sapolsky has found that long-term stress increases ones risk of diabetes, cardiac problems, and gastrointestinal disorders. Stress suppresses the immune system. It causes reproductive dysfunction in men and women. It suppresses growth in kids. In affects developing fetuses. Newer evidence even shows it causes faster aging of DNA. But potentially worst of all is what it does to the human mind.

Prolonging fight-or-flight into a chronic condition means that neurons in the brain related to things like learning, memory, and judgment all suffer the consequences thanks to the wide-ranging effects of our double-edged sword stress hormones called glucocorticoids. Recent research has even shown this response made chronic is a self-perpetuating cycle. A constantly stressed out brain appears to lead to a kind of hardening of neural pathways. Essentially, feeling chronic stress makes it harder to not perceive stress, creating a vicious cycle of unending stress.

On top of this, and related back to Weisss rats and human attribution theory, is the coping responses of those who are stressed out. Think of the off-lever in the second rats cage. There are many such levers around us and although they can be effective in reducing our stress levels, many of them are arguably pretty bad off-switches. These responses include acting out against others, otherwise known as displacement aggression or bullying.

Yes, bullying is an effective coping mechanism. As the saying goes, shit rolls downhill, and theres actually a scientific reason for that other than gravity. In a hierarchy, it is healthier after a loss to start another fight with someone you can beat, than to mope about the loss. The former is the abdication of control, a form of learned helplessness, and the latter is the creation of control, a kind of learned aggressiveness.

A society full of unhealthy people getting sick more than they otherwise would be, saddled with difficulties learning and remembering, suffering from weakened judgment and short-term survival thinking, and violently turning on each other as a means of coping is not a recipe for success. Its a recipe for disaster.

Life in the 21st century is full of both. On the learned helplessness side, there have been an estimated 45,000 suicides per year since 2000, with a sharp rise since 2007, that can all be attributed to the stresses surrounding the economic insecurities of unemployment and underemployment. The U.S. is even confounding the world, with a mysterious and dramatic rise in mortality rates among middle-aged white men and women, who all appear to be drinking and overdosing themselves to death.

On the displacement aggression side, we see bullying of traditionally marginalized groups and a global and marked increase of anti-immigrant sentiment which has already led directly to the election of Donald Trump and as a result, cries for border walls and travel bans. We are seeing a rise in authoritarianism, which is fundamentally a cry for more control and predictability.

A society full of unhealthy people getting sick more than they otherwise would be, saddled with difficulties learning and remembering, suffering from weakened judgment and short-term survival thinking, and violently turning on each other as a means of coping is not a recipe for success. Its a recipe for disaster, especially faced with species-endangering challenges like climate change that demand long-term thinking. But there is hope, and that hope springs from the same well as our problems.

There is an animal out there, one of our cousins actually in the primate family, who lead somewhat similar lives to us. They are high enough in the food chain to generally not be bothered and smart enough to be the primary cause of each others problems. Or as Sapolsky has described it: Theyre just like us: Theyre not getting done in by predators and famines, theyre getting done in by each other. That animal is the baboon and its the animal Sapolsky has been studying for decades. In doing so, hes found three primary factors in predicting stress levels.

The first predictor is the social hierarchy itself. Those at the top tend to live the most stress-free lives thanks to having more control, and those at the bottom tend to live the most stressful lives, thanks to having less control. There is however an important caveat to this. The stability of the social hierarchy matters. If the top baboon faces what is effectively a baboon revolution, that can be pretty stressful. In other words, more unequal societies lead to more stress, for everyone.

The second primary factor is personality. Just as primates are smart enough to be stressed where other animals wouldnt, theyre also able to not be stressed where others would. A baboon who worries for his life every time another baboon walks by is going to be far more full of stress hormones than a laid-back baboon. Personality is therefore a factor that can override ones position in the hierarchy for better or worse. It can even strongly predict ones rank.

The third primary factor actually trumps all. It turns out that stress-related diseases are powerfully grounded in social connectedness. At the bottom of the social hierarchy and prone to stressing out based on your personality? That can still be okay for your health and well-being as long as you have strong social supports friends, family, and community to override it all. Sometimes all we really need is to know we are not alone.

This social trump card even helps explain the prevalence of religion in human societies. Its the creation of a perceived control lever that reduces stress across all factors including the all important social support factor. The result is that attending religious services regularly is actually surprisingly good for human health.

All of this goes a long way toward explaining a great deal of human behavior. The construction of a social hierarchy is a naturally emergent phenomenon of our biology. Being above someone else in rank offers a level of control and predictability. Our personalities help determine our ranks and also how we cope with a lack of control and predictability. Our social relationships help put our lives and the world around us into perspective. However, this is no meritocracy and much depends on the circumstances of birth.

Because our personalities are greatly determined by our environments, especially as kids, a positive feedback loop can emerge where those born and raised in high stress environments full of impoverishment and inequality are unable to escape those environments. This can then become self-perpetuating through each successive generation that follows. We see this happening right now. For all those born into the bottom fifth of American society, about half remain there as adults. The same is true for the top fifth. Meanwhile, the middle 60% are twice as mobile as either one. If we care about the American Dream, we should consider the implications.

Whats the result of such generational stratification of little social mobility? One need look no further than our coping mechanisms the levers of control we create to understand why so many things we dont want, emerge from highly unequal societies. Remember displacement aggression? A 1990 study of 50 countries concluded economic inequality is so significantly related to rates of homicide despite an extensive list of conceptually relevant controls, that a decrease in income inequality of 0.01 Gini (a measure of inequality) leads to 12.7 fewer homicides per 100,000 individuals. Simply put, and this is a robust finding, growing inequality leads to growing violence. A meta-analysis of 34 separate studies even found 97% of the correlations reported between social inequality and violent crime to be positive, meaning as one got bigger or smaller, the other got bigger or smaller.

Addictions are another result. Drug use is a lever of control that is also an escape. We may not be able to control anything around us, but we can control an entirely personal decision that is as simple as drinking that vodka or smoking that cigarette. It can function as the middle finger to everything and everyone around us as a way of saying, I may be stuck in this cage, but you cant stop me from using this to feel like Ive escaped, if only temporarily, and if even only an illusion. This is me controlling the one thing I can control myself. Consider again the mysteriously growing mortality rates of middle-aged white people due to overdoses and liver disease.

As economic inequality increases, other scientifically correlated effects include: reduced trust and civic engagement, eroded social cohesion, higher infant mortality rates, lower overall life expectancy, more mental illness, reduced educational outcomes, higher rates of imprisonment, increased teen pregnancy rates, greater rates of obesity, and the list continues to grow as inequality-related research grows.

Additionally, if you look closely at such a list of effects, it shows the erosion of social supports. If you are less likely to trust your neighbor, if you arent as involved in your community, if you or those you interact with are more aggressive, if you are depressed and just want to be alone, that means the all important trump card for handling stress social connectedness vanishes. This too is its own feedback loop. Less social connection means more stress which means less social connection. Its an unending cycle for human misery.

Its also exactly what weve been observing in the United States for decades. Robert Putnam wrote an entire book about it back in 2000 titled Bowling Alone. The title originated from the statistic that although more people are bowling, less people are doing it in leagues. As observed by Putnam:

Community and equality are mutually reinforcing Social capital and economic inequality moved in tandem through most of the twentieth century. In terms of the distribution of wealth and income, America in the 1950s and 1960s was more egalitarian than it had been in more than a century Those same decades were also the high point of social connectedness and civic engagement. Record highs in equality and social capital coincided. Conversely, the last third of the twentieth century was a time of growing inequality and eroding social capital The timing of the two trends is striking: somewhere around 196570 America reversed course and started becoming both less just economically and less well connected socially and politically.

Viewed through Sapolskys decades of scientific investigation into the physiology of stress, and backed by everything weve observed since theGreat Decoupling in 1973 where national productivity has continued to grow but wage growth has been non-existent, it becomes disappointingly clear that all of this is actually of our own making. Through the policy decisions weve made to increase inequality in the blind pursuit of unlimited growth through the cutting of taxes and subsidizing of multi-national corporate interests, and through the pursuit of globalization without regard for its effects on the middle classes of developed nations such that 70% of households in 25 advanced economies saw their earnings drop in the past decade, weve created a societal feedback loop for chronic stress. And were paying the price.

But it doesnt have to be this way. Just as we know more about why things are the way they are because of some rats in cages and some baboons in East Africa, those same animals point the way forward.

In what was a sad day for Sapolsky but a remarkable day for science, he discovered back in the mid-1980s that the very first baboon troop hed ever studied had experienced a die-off. Half of the troops males had died of tuberculosis from eating tainted garbage. Because those at the top did not allow weaker males and any of the females to eat their prize trash, all of them died. The result was a truly transformed society of baboons.

A greater sense of egalitarianism became the new rule of the jungle, so to speak. Bullying of females and lower males became a rarity, replaced with aggression limited to those of close social rank. Aggressive behaviors like biting were reduced while affectionate behaviors like mutual grooming were increased. The baboons got closer, literally. They sat closer to each other. Stress plummeted, even among those at the very bottom of the new hierarchy. Even more amazingly, this happier more peaceful society of baboons has lasted over the decades, despite members leaving and joining.

In what appears to be a transmission of societal values, new baboons are taught that in this particular society, bullying is not tolerated and tolerance is more the general rule, not the exception. Essentially, a new feedback loop was created, where the sudden reduction in inequality led to less stress and greater community, which led to a new normal of less stress and greater community. As Dr. Frans B. M. de Waal, the director of the Living Links Center at the Yerkes National Primate Research Center of Emory University put it in a 2004 interview with the New York Times about the baboon findings, The good news for humans is that it looks like peaceful conditions, once established, can be maintained.

As much as the story of these baboons have to reveal about the importance and the hope of a less stressed-out, more peaceful society, there is another animal story that in my opinion shows the most potential for mankind of all.

In what has become a very well-known and discussed kind of study, rats were put into cages and given the opportunity to press a lever to self-administer drugs like cocaine. They medicated themselves to death and thus went down in history as the kind of experiment to point to that reveals the helplessly addictive dangers of drugs and how we must be protected from their usage for our own good. This is the ammunition for the War on Drugs in a nutshell.

Meanwhile, in what has become a far too little known variation of this study, but I consider to be one of the most important ever devised, a new kind of experiment was run in an entirely different environment called Rat Park.

Hypothesizing that perhaps having nothing to do but just exist alone in a cage may have something to do with drug usage, a psychologist namedBruce Alexander decided to create a kind of rat heaven before offering rats drugs. Instead of a cage, rats were given a huge space to roam between tree-painted walls and a forest-like floor, full of toys and other rats to play and mate with, food to eat, obstacles to climb, tunnels to traverse, etc.

Within this paradise for rats, morphine-laced water was introduced. The rats could drink as much of it as they wanted. Incredibly, the rats didnt care for it, opting for plain water instead. The morphine-water was then made sweeter and sweeter until eventually the rats finally drank it, but only because it apparently tasted so good, not for the narcotic effects. This was even confirmed by adding a drug to the water, Naltrexone, that nullified the effects of the morphine, which resulted in the rats drinking more of the water. All of this was in strong contrast to solitary rats in cages given the same choices, who took to the morphine-water immediately and strongly.

In fact, its even been found that solitary existence within a cage actively prevents neurogenesis the growth of new neurons within the brain. It turns out neuroscientists for decades thought it impossible for adults to grow new neurons because they were studying solitary animals in cages the whole time. Its therefore only recently that weve learned that impoverished environments actively limit brain development.

Building a paradise for humans is up to us, where because everyone has enough, and inequality is low enough, we wont reach for those levers of control that end up being against our better interests.

What this all reveals is more than the great lie of the Drug War. It reveals the vast importance and great differences of living alone in a cage, and living in a world of abundance and social bonds. Viewed in the context of everything else discussed, it shows the importance of constructing an environment for the purpose of bringing out the best in us, instead of the worst in us. Building a paradise for humans is up to us, where because everyone has enough, and inequality is low enough, we wont reach for those levers of control that end up being against our better interests. So how do we build Human Park?

It is only in my studies of the idea of basic income that Ive seen glimpses into this idea of a Human Park. Like a bunch of puzzle pieces that can be collected to form into a picture, the evidence behind simply giving people money without strings forms a profound image of a better world that can exist right now, if we so choose. Remember the three primary factors that determine our levels of stress?

Creating a less unequal society is step one. There exists in the world today, and has since 1982, something as close to a fully universal basic income as anything yet devised. Its the annual Alaska dividend where thanks to every resident receiving a check for on average around $1,000 per year for nothing but residing in Alaska, inequality is consistently among the lowest of all states. Not only that, but we see what wed expect to see in lower stress populations, where Alaska is also consistently among the happiest states.

In Gallups 2015 ranking of states by well-being, Alaska was second only to Hawaii. This annual ranking is a combined measure of five separate rankings: purpose (liking what you do each day and being motivated to achieve your goals), social (having supportive relationships and love in your life), financial (managing your economic life to reduce stress and increase security), community (liking where you live, feeling safe and having pride in your community), and physical (having good health and enough energy to get things done daily). Alaska scored 5th, 5th, 1st, 7th, and 6th respectively in each of these measures.

In other words, in the only state in the U.S. to provide a minimum amount of income to all residents every year, such that no one ever need worry about having nothing, they feel the greatest amount of basic economic security and the least amount of stress than any other state. As a result theyre also among the most motivated, the healthiest, and have strong family, friend, and community social supports. Alaska is essentially a glimpse at Human Park, but only a glimpse because even the $2,100 they all received in 2015 is not enough to cover a years worth of basic human needs.

Some more of the best evidence we have in the world for what happens in the long-term when people are provided something that looks even more like a basic income than is found in Alaska, can again be found in the U.S., in North Carolina.

In 1992, the Great Smoky Mountains Study of Youth began with the goal of studying the youth in North Carolina to determine the possible risk factors of developing emotional and behavioral disorders. Because Native Americans tend to be underrepresented in mental health research, researchers made the point of including 349 child members of the Eastern Band of the Cherokee Nation. About halfway into the ten-year study, something that is the dream of practically any researcher happened as a matter of pure serendipity. All tribal members began receiving a share of casino profits. By 2001 those dividends had grown to $6,000 per year. By 2006, they were $9,000 per year. The results were nothing short of incredible.

The number of Cherokee living in poverty declined by 50%. Behavioral problems declined by 40%. Crime rates decreased. High school graduation rates increased. Grades improved. Home environments were transformed. Drug and alcohol use declined. Additionally, the lower the age the children were freed of poverty, the greater the effects as they grew up, to the point the youngest ended up being a third less likely to develop substance abuse or psychiatric problems as teens.Randall Akee, an economist, later even calculated that the savings generated through all the societal improvements actually exceeded the amounts of the dividends themselves.

However, the most powerful finding of all was in personality effects. These changes were observed as a result of better home environments that involved less stress and better parental relationships. Incredibly, the children of families who began receiving what we can call something very close to a basic income, saw long-term enhancements in two key personality traits: conscientiousness and agreeableness. That is, they grew up to be more honest, more observant, more comfortable around other people, and more willing to work together with others. And because personalities tend to permanently set as adults, these are most likely lifelong changes.

If we remember how important personality is to the perception of stress and ones location within social hierarchies, these children will end up far better off, and as a result, their own children likely will as well. This is another glimpse into a basic income-enabled Human Park.

Although whats been happening for years in both Alaska and North Carolina are close to universal basic income in practice, they are not actually UBI. UBI requires regularly giving everyone in an entire community an amount of money sufficient to cover their basic needs. This has been done in three places so far: the city of Dauphin in Canada, the Otjivero-Omitara area of Namibia, and the Madhya Pradesh area of India.

Its in these areas that humanity has achieved whats closest to creating Human Parks. As a direct result of guaranteeing everyone a basic income in Dauphin, hospitalization rates decreased 8.5% and high school graduation rates surpassed 100% as dropouts actually returned to school to finish. In Namibia, overall crime rates were cut almost in half and self-employment rates tripled. In India, housing and nutrition improved, markets and businesses blossomed, and overall health and well-being reached new heights. But if its one thing I find most interesting across all experiments, its the improved social cohesion a proliferation of new and strengthened social supports.

In Namibia, a stronger community spirit developed. Apparently, the need to ask each other for money was a barrier to normal human interaction. Once basic income made it so that no one needed to beg anymore, everyone felt more able to make friendly visits to each other, and speak more freely without being seen as wanting something in return. In India, where castes can still create artificial social divisions, those in villages given basic income actually began to gather across caste lines for mutual decision-making. And in Canada, the basic income guarantee had a notable impact on caring, with parents choosing to spend more time with their kids, and kids spending more time with each other in schools instead of jobs.

Remember, social supports are the trump card of societies with less stress, and it appears that providing people with UBI strengthens existing social supports and creates new ones. Freed from a focus on mere survival, humans reach out to each other. This is also something that makes us different from every other animal on Earth our ability to reach each other in ways unimaginable even to ourselves until only recently. We as humans are entirely unique in our ability to belong to multiple hierarchies, and through the internet create connections across vast distances and even time itself through recorded knowledge.

Our place in a hierarchy matters, but we can decide which hierarchies matter more. Is it our position in the socioeconomic ladder? Is it our position in our place of employment? Or is it our position in our churches, our schools, our sports leagues, our online communities, or even our virtual communities within games like World of Warcraft and Second Life?

No other policy has the transformative potential of reducing anywhere near as much stress in society than the lifelong guaranteeing of basic economic security with a fully unconditional basicincome.

We as humans have incredible potential to create and form communities, and realize world-changing feats of imagination, and this mostly untapped potential mostly just requires less stress and more time. If all were doing is just trying to get by, and our lives are becoming increasingly stressful, it becomes increasingly difficult to think and to connect with each other. Its the taxation of the human mind and social bonds. Studies even show the burden of poverty on the mind depletes the amount of mental bandwidth available for everything else to the tune of about 14 IQ points, or the loss of an entire nights sleep. Basically, scarcity begets scarcity.

On the other hand, if we free ourselves to focus on everything else other than survival, if we remove the limitations of highly unequal and impoverished environments, then were increasingly able to connect with each other, and we minimize learned helplessness. As a result, our health improves. Crime is reduced. Self-motivation goes up. Teamwork overtakes dog-eat-dog, and long-term planning overtakes short-term thinking. Presumably, many an IQ jumps the equivalent of 14 points. A greater sense of security has even been shown to reduce bias against out groups, from immigrants to the obese. And if we take into account the importance of security in people deciding to invest their time and resources in bold new ventures, innovation also has the chance of skyrocketing in a society where everyone always has enough to feel comfortable in taking risks without fear of failure. Basically, abundance begets abundance.

If what we seek is a better environment for the thriving of humans a Human Park full of greater health and happiness then what we seek should be the implementation of basic income, in nation after nation, all over the world. There is no real feeling of control without the ability to say no. Because UBI is unconditional, it provides that lever to everyone for the first time in history. No other policy has the transformative potential of reducing anywhere near as much stress in society than the lifelong guaranteeing of basic economic security with a fully unconditional basic income. Plus, with that guarantee achieved, the fear of technological unemployment becomes the goal of technological unemployment. Why stress about automation, when we could embrace it?

No more fight-or-flight.

Its time for live long and prosper.

Read more:
Evidence Indicates That Universal Basic Income Improves Human Health - Futurism

Combining genetics, herd health and compact calving on a Co. Kerry dairy farm – Agriland

Dairy farmer John P. Galvin milks 80 cows in a compact spring-calving system overlooking the Dingle Peninsula in Lispole, Co. Kerry.

Galvins land goes right down to the Atlantic Ocean and receives 1,600-1,700mm of rainfall on an annual basis.

Last year, John sold 477kg of milk solids from each cow in his herd to the Kerry Group at 4.22% fat and 3.62% protein.

This output per cow, combined with the high percentages, resulted in a high milk price and helped John greatly in the difficult year that 2016 was.

The herd also featured in the recent top 200 EBI herds in Ireland, sitting in 149th place, with a herd EBI of 129. The herds EBI is balanced between milk (44), fertility (51) and calving (33).

John uses the Munster AI technician service and combines the fresh semen programme with the year one genomic tested sires.

The AI technician, via his handheld, ensures that no inbreeding occurs.

This service allows John to concentrate solely on heat detection during the breeding season knowing that he is receiving the very best genetics available, from a highly skilled Munster AI technician, and completely avoiding inbreeding.

The genetic progress being made is evident from the EBI graph.

The fertility performance of the herd is impressive, with over 85% of the herd calving in just six weeks.

This is achieved through a high submission rate, due to excellent heat detection and a high conception from the AI technician.

Johns heat detection is exceptional; scratch cards are used on the heifers. Cows not detected in heat three weeks into the breeding season are examined and treated.

John monitors the health status of his herd and the efficacy of his vaccination and parasite control programme annually, through the Munster Herd Health programme.

He finds the end-of-year meeting with the Munster vet invaluable, for reviewing his performance and helping him with decisions in which he plans the dry period and the year ahead.

For the past two years, he has carried out Johnes Disease screening through milk recording.

Both these programmes ensure that output is maintained each year and that high genetic breeding stock, with a high health status, can be sold off the farm.

The Kerry-based dairy farmer attributes the performance of his herd to their genetics, health and a compact spring-calving pattern.

Performance is monitored by monthly milk recording from February to November. John is now firmly of the opinion that each cow needs to be contributing to the bottom line for him to maximise his profitability.

The real profit drivers are the mature third lactation plus cows, calving in February.

In 2016, the top 10 mature cows averaged 7,300kg of milk, with 569kg of milk solids at 4.14% fat and 3.65% protein.

A feature of the herd is the consistent level of production between the cows, with no poor performers.

The first milk recording of 2017 was completed on March 7. This allows the early identification of any SCC issues andtheir immediate correction.

This, in turn, allows all cows to reach their full potential over the lactation period.

As all cows and heifers are bred to dairy sires, John has surplus heifers to sell each year as calves, maidens or in-calf heifers.

One can have confidence that these high genetic merit heifers from a high health status herd will perform and remain in the herd for a long time for their new owners.

John has bred a few bulls that have entered AI; the most popular being JKF (IG) Doonmanagh Jacko an FLT son from a great DEU cow.

He is looking forward to producing a genetic gem from his herd on the Dingle peninsula an area that has produced so many footballing legends down through the years.

To find out more about the services offered by Munster AI: Click Here

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Combining genetics, herd health and compact calving on a Co. Kerry dairy farm - Agriland

Genetics of Oil Drilling – GenomeWeb

A few US shale oil producers are using DNA sequencing to identify promising wells, Reuters reports. It adds that it's part of companies' efforts to cut costs and keep pace with global oil producers.

The companies are testing DNA extracted from microorganisms found in rock samples to compare to DNA found in oil samples. Similarities and differences in their genetic profiles are then used to find locations that are more likely to have oil.

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Genetics of Oil Drilling - GenomeWeb

Breakthrough genetics looking at cutting nitrogen leaching – Scoop.co.nz (press release)

Press Release CRV Ambreed

CRV Ambreed has made a genetic discovery that it anticipates will result in a more sustainable dairy industry and potentially reduce nitrogen leaching on New Zealand farms by 20% within 20 years.

Media release

Embargoed to 9am 29 March 2017

Breakthrough genetics looking at cutting nitrogen leaching by 20% in NZ CRV Ambreed

CRV Ambreed has made a genetic discovery that it anticipates will result in a more sustainable dairy industry and potentially reduce nitrogen leaching on New Zealand farms by 20% within 20 years.

In whats thought to be an international first, the dairy herd improvement company has announced it will market bulls that are desirable for traditional traits as well as being genetically superior for a new trait that is related to urea nitrogen in milk.

CRV Ambreed is now selling semen from bulls whose daughters will have reduced concentration of Milk Urea Nitrogen (MUN) under a LowN Sires brand. MUN is a measure of the amount of nitrogen contained as milk urea, and CRV Ambreed R&D Manager Phil Beatson says theres overwhelming international evidence of a direct connection between MUN and the amount of nitrogen excreted in urine when fed different diets.

If this connection carries over, cows bred for lower levels of MUN are expected to excrete less nitrogen in their urine which will, in turn, reduce the amount of nitrogen leached from grazed pasture, Mr Beatson says. Daughters of CRV Ambreeds 2017 LowN Sires could potentially save New Zealand 10 million kilograms in nitrogen leaching a year, based on a national herd number of 6.5 million dairy cattle. He says CRV Ambreeds projections indicate that its possible to breed cattle that will reduce nitrogen leaching by 20% within 20 years.

CRV Ambreed Managing Director Angus Haslett says the firm has been researching the connection between MUN and nitrogen in urine for five years. The link between MUN and lower nitrogen output has been acknowledged before in international research, but this is the first time in the world that genetics for low MUN is being marketed with the aim being to reduce nitrogen leaching.

Hundreds of thousands of straws of semen from a team of more than 20 existing top-performing bulls with desirable genetic makeup for low levels of MUN, known as LowN Sires, are already available for use in 2017.

Mr Haslett says this is a continuation of CRV Ambreeds ongoing work to breed for particular traits that improve New Zealands dairy herds for health and environmental reasons. The future is about using genetics for better breeding and CRV Ambreed has been operating in the future for some time. Farmers are already using genetics to breed cows that are more tolerant to Facial Eczema and for breeding polled calves that will not need costly and time-consuming de-budding.

He says while there is a vast amount of research being conducted and proposed in New Zealand to mitigate nitrogen leaching, it makes sense to look at breeding cows that produce less nitrogen from economic and environmental viewpoints. CRV Ambreed will be the first organisation in New Zealand and possibly the world to provide a long-term genetic solution to nitrogen leaching by identifying and selecting bulls for low MUN genes.

Genetics can produce great gains for farmers, he says. Farmers already choose CRV Ambreed bulls to breed certain traits in their cows, so this is another step on that journey of finding solutions in genetics.

Mr Haslett says there is still research to be done to further test and confirm the genetic development and CRV is working with DairyNZ, AgResearch and Lincoln University on this. CRV Ambreed is very positive about the potential benefits the discovery will deliver for farmers and the nation.

The genetic announcement has been welcomed by major industry players such as DairyNZ. DairyNZ Strategy and Investment Leader for Productivity, Dr Bruce Thorrold, says the potential for farmers to reduce nitrogen leaching by breeding cows with lower urinary nitrogen output is exciting.

If the planned science proves the link between breeding for MUN and urinary nitrogen output, this would give farmers in nitrogen-limited regions such as Canterbury more options to reduce nitrogen leaching without going away from a pasture-based system. Animal breeding would potentially add to gains from DairyNZ investment in research on managing nitrogen inputs, using stand-off and finding plants with lower nitrogen content.

CRV Ambreed has already briefed some of New Zealands regional councils about the discovery as many regional councils are working with farmers to minimise nitrogen leaching.

For more information, visit http://www.crv4all.co.nz/lownsires

About CRV Ambreed:

CRV Ambreed has an overarching ethos of better cows, better life and its business is built around one goal: helping its customers achieve their highest performing herd possible. The company proactively manages ongoing changing market demands by offering innovative solutions tailored to customers needs.

Content Sourced from scoop.co.nz Original url

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Breakthrough genetics looking at cutting nitrogen leaching - Scoop.co.nz (press release)

Should the 14-day limit on embryo research be extended? – Prospect (blog)

Strict regulation can helpnot hinderscientific progress by Philip Ball / December 12, 2016 / Leave a comment

Human embryonic stem cells, in cell culture

In 1984, a committee appointed by the British government to draw up guidelines for in vitro fertilisation (IVF) in the wake of the birth of Louise Brown, the first test-tube baby, recommended that scientific research on human embryos should be permitted up to a maximum of 14 days after conception.

The recommendations of this report, led by moral philosopher Mary (now Baroness) Warnock, didnt become law until the Human Fertilisation and Embryology Act was passed by parliament six years later. Among other things, the act set up the Human Fertilisation and Embryology Authority (HFEA) to license and regulate all in vitro embryo creation and manipulation, whether for IVF or for scientific research. Violations of the 14-day limit became a criminal offence.

That limit has remained in place ever since. But now some scientists believe it should be extended to 28 days. These proposals were discussed on 7th December at a meeting in London organised by charity the Progress Educational Trust. It marked the beginning of what seems likely to be a broad and extended discussion among scientists, bioethicists, fertility specialists, religious leaders and others who have a stake in the moral, legal and scientific status of the human embryo.

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Should the 14-day limit on embryo research be extended? - Prospect (blog)

B v B (Fertility Treatment – Paperwork Error) [2017] EWHC 599 (Fam) – Family Law Week

Home > Judgments

Case summary coming soon

Neutral Citation Number: [2017] EWHC 599 (Fam)Date: 23 March 2017

IN THE HIGH COURT OF JUSTICE FAMILY DIVISION

THE HONOURABLE MR JUSTICE PETER JACKSON - - - - - - - - - - - - - - - - -

BETWEEN:

B Applicant - and B and LEEDS TEACHING HOSPITALS NHS TRUSTRespondents B v B (Fertility Treatment: Paperwork Error) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Mr Karl Rowley QC (instructed by Harrison Drury & Co) appeared on behalf of the Applicant The First Respondent attended in person David Birch (Capsticks) appeared on behalf of the Second Respondent - - - - - - - - - - - - - - - - - - This judgment may be published provided the individuals concerned are not identified.

Failure to comply with this condition may be a contempt of court. J U D G M E N T Mr Justice Peter Jackson: 1.This is an application for a declaration of parentage under s.55A Family Law Act 1986. It is in effect made by a married couple, although he is formally the applicant and the other the first respondent, who seek an order regularising the legal position of the father in relation to a child born to a mother in 2012. The birth was the result of fertility treatment carried out at the Leeds Centre for Reproductive Medicine at Seacroft Hospital, part of the Leeds Teaching Hospitals NHS Trust.

2.The case is yet another where paperwork errors have had potentially serious legal consequences, another case where (to quote the President of the Family Division) medical brilliance has been allied with administrative incompetence. However, the couple has nothing but praise for the medical treatment they received, leading to the birth of a much-loved child. The Trust, for its part, has explained what went wrong, done everything it can to remedy matters for this family, taken steps to improve its procedures, offered an unreserved apology, and agreed to pay the legal costs.

3.The history, which I need only set out in outline, is set out in the applicant's statement and the statement of Karen Thompson, the lead embryologist and the Trust's 'person responsible' under the legislation.

4.In 2005, the couple (I will call him X and her Y), who were then engaged to be married, approached the Trust for fertility treatment. They underwent counselling and two unsuccessful treatment cycles in March and October 2006. Further treatment cycles (now with donor embryos) occurred in September 2009, March 2010, June 2010, November 2010 and September 2011, and the final one led to the child's birth.

5.The birth was registered, with both parents being named on the birth certificate. Thereafter, in September 2012, the parents married.

6.Following decisions of Cobb J ([2013] EWHC 1418 (Fam)) and Theis J ([2015] EWFC 13), the Human Fertilisation and Embryology Authority (HFEA) directed licensed clinics to audit their paperwork between 2009 and 2014. This clinic's audit covered 36 cases of children born to couples who were not married or in a civil partnership. In two cases, of which this is one, there were no HFEA consent forms (Forms WP and PP), and in one case one form was incomplete.

7.In May 2014, the Trust, no doubt aware of its error, asked the couple to sign forms WP and PP, which they did. Even then, the forms are now missing from the Trust's records. They could in any case have no independent effect as they date from after the treatment.

8.In February 2015, the Trust finally informed the couple of the problem, and in December 2016 these proceedings were issued.

The agreed fatherhood conditions 9.The Human Fertilisation and Embryology Act 2008 came into effect on 5 April 2009. From that date the non-birth partner in a couple who were not married or in a civil partnership will only be recognised as the legal parent of a child born of licensed fertility treatment using donor gametes in the UK if the 'agreed fatherhood conditions' are fulfilled.

10.Y is in law the child's mother: s.33 HFE Act 2008. Had the couple been married at the time of the treatment, X would automatically be the father: s.35.

11.As they were not married at the time of treatment, s.36 makes X (and no other person: s.38) the father if, but only if, the agreed fatherhood conditions in s.37 are satisfied at the time of the treatment.

12.Section 37 reads, so far as relevant:

37The agreed fatherhood conditions (1)The agreed fatherhood conditions referred to in section 36(b) are met in relation to a man ("M") in relation to treatment provided to W under a licence if, but only if,

(a)M has given the person responsible a notice stating that he consents to being treated as the father of any child resulting from treatment provided to W under the licence,

(b)W has given the person responsible a notice stating that she consents to M being so treated,

(c)neither M nor W has, since giving notice under paragraph (a) or (b), given the person responsible notice of the withdrawal of M's or W's consent to M being so treated,

(d)

(e)

(2)A notice under subsection (1)(a), (b) or (c) must be in writing and must be signed by the person giving it.

(3)

13.Thus, to satisfy the agreed fatherhood conditions, what is required is that

X must have given notice

In advance

In writing and signed

Stating that he consented to being treated as the father of any child

Resulting from the treatment undergone by Y

Under the clinic's licence

And Y must have given notice in the same manner.

The form of consent14.The HFEA is the body responsible for granting licences for treatment. Licences are subject to a range of mandatory conditions, including the obligation to keep proper records: Human Fertilisation and Embryology Act 1990 s.12(1)(d). In April 2009, the HFEA used its statutory powers to give a direction that the consents required under s.37 must be recorded in a specified form: respectively, Form WP ("Your consent to your partner being the legal parent") and Form PP ("Your consent to being the legal parent").

15.The HFEA direction to use the specific forms WP and PP is a condition of the clinic's licence. However, a failure to keep proper records does not of itself invalidate the licence conditions so that treatment ceases to be licensed treatment to which s.37(1) applies. This issue, which arose before Cobb J and Theis J, was resolved by the President in In the matter of the Human Fertilisation and Embryology Act 2008 (Cases A, B, C, D, E, F, G and H) [2015] EWHC 2602 (Fam). I respectfully agree with his conclusions, summarised at paragraph 63:

63.I conclude, therefore, that, in principle:

i) The court can act on parol evidence to establish that a Form WP or a Form PP which cannot be found was in fact properly completed and signed before the treatment began;

ii) The court can 'correct' mistakes in a Form WP or a Form PP either by rectification, where the requirements for that remedy are satisfied, or, where the mistake is obvious on the face of the document, by a process of construction without the need for rectification.

iii) A Form IC, if it is in the form of the Barts Form IC or the MFS Form IC as I have described them above, will, if properly completed and signed before the treatment began, meet the statutory requirements without the need for a Form WP or a Form PP.

iv) It follows from this that the court has the same powers to 'correct' a Form IC as it would have to 'correct' a Form WP or a Form PP.

By way of footnote, the President added:

"I express no views in relation to similar forms used by these or other clinics. I also make clear that nothing I have said should be treated as any encouragement to anyone not to use Form WP and Form PP."

16.The result was that the President found that the internal consent (IC) forms used in those cases were sufficient to satisfy s.37 in Case C (where no WP/PP forms were signed), and that they would have been sufficient in Case E and in Case F (where WP/PP forms had been lost). In addition to these three cases, the later decision of the President in Case M [2016] EWHC 1572 (Fam), in which signed IC forms were found to amount to valid consents, is also in point, as are the similar Cases P, Q, R, T, U, W and X: [2017] EWHC 49 (Fam).

17.To take an example, the father in Case M stated that:

"I am not married to [Y], but acknowledge that she and I are being treated together, and that I will become the legal father of any resulting child."

Y, however did not make a similar declaration in the same form. The IC forms in the three other cases (Cases C, E and F see paragraphs 29-31 of the judgment in Cases A etc.) were in somewhat similar terms to Case M, referring to becoming 'legally responsible', or to becoming 'the father', or 'the legal father'.

18.The question, not answered in the above cases, is whether in very similar overall circumstances, but with different IC forms, the same conclusion should be reached in the present case.

What is being consented to19.The statute requires consent to a man being treated as the father of any child resulting from the relevant licensed treatment. In the nature of things, treatment may be provided in cycles, as happened here. However, this does not mean that consent has in every case to be renewed before each individual treatment cycle, if the reality is that the couple are engaged in a continuous series of treatments to which their earlier consent is intended to apply. This point was considered and explained by the President in Case U: see paragraph 19 of the judgment. This is not to discourage renewal of consent, but what matters is that valid informed consent can be seen to apply to the treatment that is being provided. So, on the facts, a single consent may well apply to a series of treatment cycles. The existence of consent is a question of fact and it will all depend on the facts of the individual case.

What occurred in this case20.I find as facts that (as in Case M and the other similar cases):

(1)The treatment which led to the birth of the child was embarked upon and carried through jointly and with full knowledge by both X and Y.

(2)It was a single course of treatment, albeit that it took place in stages. If I am wrong about that (and it makes no difference to the outcome) the treatment that led to the child's birth was a single course of treatment beginning in 2009.

(3)From the outset and throughout, it was the couple's joint intention, and that of the clinic, that X would be a legal parent of the child. Each parent was aware that this was a matter which, legally, required the signing by each of them of consent forms. Each of them believed that they had signed the relevant forms as legally required and, more generally, had done whatever was needed to ensure that they would both be parents.

(4)From the moment when the pregnancy was confirmed, both X and Y believed that X was the other parent of the child. That remained their belief when the child was born.

(5)X and Y, believing that they were entitled to, and acting in complete good faith, registered the birth of their child, as they believed the child to be, showing both of them on the birth certificates as the child's parents, as they believed themselves to be.

(6)The first they knew that anything might be 'wrong' was when, some years later, they were contacted by the clinic.

(7)X's application to the court is wholeheartedly supported by Y.

21.I further find that as part of the paperwork surrounding their treatment, this couple participated in numerous significant steps:

(1)In December 2005, Y signed HFEA form [007], consenting to being treated together with X: that being the criterion under the 1990 legislation.

(2)In January 2006, X and Y jointly attended counselling to explore the implications of undergoing fertility for themselves and the resulting child.

(3)In December 2005 and June 2006, they jointly signed the Trust's IC form entitled 'Consents For Treatment'. This form states that it covers 'all aspects of treatment'. It ran to 26 pages and has a strong appearance of formality. In its preamble it refers to the need to 'identify individuals who will have the parental responsibility and which person/s will be responsible for the raising of the child or children that may be born as a result of treatment.' By signing the form X and Y specifically acknowledged that they would be responsible for the 'maternal nurturing' and 'paternal nurturing' of the child.

(4)On both dates, X (in Y's presence) signed the IC form consenting to the treatment and stating that:

"I am the husband/partner of [Y] and I consent to the course of treatment outlined above. I understand that I will become the legal father of any resulting child."

(5)On both dates, they jointly signed the IC form stating that they understood that the donor had consented to his not becoming the legal father of the child.

(6)On both dates, they jointly consented to embryo transfer, and to a number of other procedures regarding genetic material.

(7)In November 2006, they again signed an IC form to the same effect as that at (3-6) above.

(8)In 2007, they were seen at the clinic in relation to treatment that did not then take place as a donor pulled out.

(9)On 2 April 2009, they were seen by the embryologist who was then the Trust's responsible person to discuss further treatment with a donor embryo. It was this form of treatment that continued until the successful conception. The very imminent change in the law does not appear to have been discussed.

(10)In April 2009 and November 2009, they again jointly signed an IC form to the same broad effect as at (3-6) above.

(11)There is a note on the IC form just mentioned, written by the member of staff who witnessed the signatures in September and November 2009. It states: 'HFEA form signed'. What this means is unfortunately not known.

(12)In March, June and November 2010, the couple again jointly signed an IC form equivalent to those referred to at (3-6) above, though the form is not now to hand.

(13)In June 2011, they again jointly completed an IC form. This form, which differs from the earlier forms, includes a checklist which itself includes reference to 'The Legalities of Embryo Donation', including 'HFEA', 'Current Law' and 'Birth Certificate'. On this occasion, X and Y both signed a declaration that they understood that donors who had given effective consent would not be the legal parents of any resulting child, and acknowledged that they had been given information about the legalities of embryo donation.

22.Administratively, this is an unhappy picture. It can be seen that the couple signed a mass of consent paperwork in the reasonable belief that the Trust was ensuring that the legal position of themselves and any child born to them was being secured. However, the question is not what they were entitled to expect, but what the legal effect of their actions was.

Argument23.On behalf of the applicant, Mr Rowley QC submits that there is sufficient material for the Court to be able to conclude that the provisions of s.37 are satisfied. In 2005 and 2006 X explicitly confirmed in Y's presence, as witnessed by a member of the clinic's staff, that he would become the legal father. There is then joint confirmation on no fewer than ten occasions between 2005 and 2011 (six of which related to the treatment with donor embryos after September 2009) that

they would be the persons responsible for any child

they were to be responsible for nurturing any child

the donors would not be the legal parents of any child

What, asks Mr Rowley, would have been the purpose of their acknowledging responsibility for the child to the exclusion of the donors unless they knew and intended to convey that they would be the child's legal parents?

24.Mr Rowley fairly draws attention to the fact that the IC form in this case is not the same as that in Case M, or the IC forms in the three other cases (Cases C, E and F see paragraphs 29-31 of the judgment in Case A etc.) which referred to the partner becoming 'legally responsible', or to becoming 'the father', or 'the legal father'.

25.Finally, Mr Rowley urges that any other reading of the documents in this case would leave this family in a deeply unsatisfactory position. The only other way of X becoming the child's legal parent would be by adoption, which is seen as utterly inappropriate as a remedy in cases like this: see Case A, paragraph 71(vii) and Case I, paragraph 24 at [2016] EWHC 791 (Fam).

Conclusion26.I stand back and consider whether, as the statute requires, X gave written notice that he consented to being treated as the father of any resulting child and whether Y gave notice that she too consented to that. Having done so, my conclusion is that these conditions are satisfied in this case. Whether the treatment is considered to have begun in 2006 or 2009, the whole tone was set by the consents signed by X in the presence of Y and the clinic in 2005 and 2006 to his becoming the legal father of any resulting child. Thereafter, at each stage of the treatment, the couple gave signed, written notice to the clinic evidencing their consent to X becoming the child's father. The fact that the forms do not contain the wording that is to be found in in Forms WP and PP is no more than a reflection of administrative incompetence on the part of the Trust. What matters is the substance and total effect of the documents, which clearly express the intention of the couple to be treated as full and equal legal parents. Had they been asked at the time what they were doing in signing these documents, they would have said that they were doing what was necessary to achieve this parenthood. Had the clinic been asked what the couple was doing in signing these documents, it would have agreed. The difficulty here only arose because the clinic failed to give the couple the recommended tools for the job, but I find that the couple still managed to get the job done with the tools that they were given.

27.I recognise that this conclusion is based on somewhat different IC forms than those considered in other cases, but nevertheless find that the agreed fatherhood condition in s.37 is satisfied in this case. It is an outcome that conforms with the twin pillars of the legislation informed consent and child welfare.

28.There will accordingly be a declaration that X is as in law (as he is in life) the child's legal parent, alongside Y. I will make a separate order in relation to the costs that are to be paid by the Trust, and will direct that the file is not to be accessed by anyone without the permission of the President of the Family Division for the time being. ____________________

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B v B (Fertility Treatment - Paperwork Error) [2017] EWHC 599 (Fam) - Family Law Week

A Glimpse Into The Earliest Genetic Mutations Of Human Life – Asian Scientist Magazine

Every time a cell in the early embryo divides, three mutations creep in; a rate much higher than previously thought.

Asian Scientist Newsroom | March 29, 2017 | In the Lab

AsianScientist (Mar. 29, 2017) - From the time a zygote first divides into two cells, very early mutations determine which cell becomes more dominant and leads to a higher proportion of the adult body. These findings have been published in Nature.

The earliest stages of human development have been impossible to study directly until now. In the present study, researchers analyzed the whole genome sequences of blood samples collected from 279 individuals with breast cancer and discovered 163 mutations that occurred very early in the embryonic development of those people.

Once identified, the researchers used mutations from the first, second and third divisions of the fertilized egg to calculate which proportion of adult cells resulted from each of the first two cells in the embryo.

They found that these first two cells contribute differently to the whole body. One cell gives rise to about 70 percent of the adult body tissues, whereas the other cell has a more minor contribution, leading to about 30 percent of the tissues. This skewed contribution continues for some cells in the second and third generation too.

Originally pinpointed in normal blood cells from cancer patients, the researchers then looked for these mutations in cancer samples that had been surgically removed from the patients during treatment. Unlike normal tissues composed of multiple somatic cell clones, a cancer develops from one mutant cell. Therefore, each proposed embryonic mutation should either be present in all of the cancer cells in a tumor, or none of them. This proved to be the case, and by using these cancer samples, the researchers were able to validate that the mutations had originated during early development.

This is the first time that anyone has seen where mutations arise in the very early human development. It is like finding a needle in a haystack. There are just a handful of these mutations, compared with millions of inherited genetic variations, and finding them allowed us to track what happened during embryogenesis, said Dr. Young Seok Ju, first author from the Wellcome Trust Sanger Institute and the Korea Advanced Institute of Science and Technology (KAIST).

During this study, the researchers were also able to measure the rate of mutation in early human development for the first time, up to three generations of cell division. Previous researchers had estimated one mutation per cell division, but this study measured three mutations for each cell doubling, in every daughter cell.

Mutations during the development of the embryo occur by two processes known as mutational signatures 1 and 5. These mutations are fairly randomly distributed through the genome, and the vast majority of them will not affect the developing embryo. However, a mutation that occurs in an important gene can lead to disease such as developmental disorders.

This is a significant step forward in widening the range of biological insights that can be extracted using genome sequences and mutations, said Sir Mike Stratton, lead author on the paper and Director of the Sanger Institute.

Essentially, the mutations are archaeological traces of embryonic development left in our adult tissues, so if we can find and interpret them, we can understand human embryology better. This is just one early insight into human development, with hopefully many more to come in the future.

The article can be found at: Ju et al. (2017) Somatic Mutations Reveal Asymmetric Cellular Dynamics in the Early Human Embryo.

Source: KAIST; Photo: Shutterstock. Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff.

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A Glimpse Into The Earliest Genetic Mutations Of Human Life - Asian Scientist Magazine

How non-muscle cells find the strength to move – Phys.org – Phys.Org

March 29, 2017 Figure: Visualization of myosin II filament stacks (yellow) with cross-linking protein alpha-actinin-1 (blue) in fibroblast cells using structured illumination microscopy. Myosin II filaments alternate with apha-actinin enriched domains along actin stress fibre. Credits: Mechanobiology Institute, Singapore

Researchers from the Mechanobiology Institute, Singapore (MBI) at the National University of Singapore have described, for the first time, the ordered arrangement of myosin-II filaments in actin cables of non-muscle cells. This work was published in Nature Cell Biology in January 2017.

Ordered arrangement of myosin-II filaments defined in non-muscle cells

The twitching contractions of our muscle cells are well known. They can be detected just weeks after conception as the embryonic heart begins beating. Muscle cell contractility is produced from interactions between protein-based cables of the cytoskeleton and small molecular motor proteins known as myosins.

There are over 200 types of cells within the human body, and not all need to repeatedly contract. Despite their distinct functions, nearly all cells contain the same basic protein components found in muscle cells. Importantly, most cells also exhibit some degree of slow contractility. Fibroblasts are one such example. Found in connective tissue, these cells produce the material that surrounds all cells, and ultimately defines tissue shape. Importantly, fibroblasts are also known to remodel this material, and for this, they need strength to pull against their environment.

To investigate the organisation of the cytoskeleton and its associated motor proteins in non-muscle cells, researchers from MBI analysed fibroblasts using a form of super resolution microscopy known as Structured Illumination Microscopy (SIM).

The researchers, who were led by Professor Alexander Bershadsky and Assistant Professor Ronen Zaidel-Bar, focused their investigation on the assembly of the cytoskeleton. Along with providing structural support to the cell, the cytoskeleton can also buffer stresses from the external microenvironment and give cells the power to contract and move through a tissue. These processes are possible due to the continual assembly and disassembly of the protein cables, and due to the generation of force as motor proteins pull on these cables.

When the cytoskeleton was viewed in living fibroblasts, Dr Shiqiong Hu, a postdoctoral researcher at MBI, and colleagues, discovered unique, organised patterns of motor protein filaments within large protein cable-like structures known as stress-fibres. These cables form dynamically and often bridge sites where the cells are interacting with the microenvironment.

Like ropes, these cables are made up of many individual filaments, held together by various cross-linking proteins. By watching the cytoskeleton form over time, the researchers observed how myosin-II filaments arranged into stacks that ran perpendicular to the large parallel stress fibres. These stacks alternated with regions of the 'cross-linking' protein a-actinin, which tethers individual filaments together to produce the protein cable.

How myosin-II filaments come to be stacked together within the bundled stress fibres, remains to be fully defined, however one observation from this study that may hold the answer, is the long range movement of myosin-II filaments towards each other. As the researchers propose, this attraction may result from contractile or elastic forces generated by the myosin filament stacks, which can transmit through the surrounding cytosol to individual filaments that are otherwise isolated.

The stacking of myosin-II filaments in non-muscle cells like the fibroblast is an intriguing element in the self-organisation of the cytoskeleton, and overall architecture of the cell. Fibroblast function requires the cell to be able to stretch, generate cytoskeletal protrusions and move to other regions of the connective tissue. The assembly and organisation of myosin-II into stacks permits the fibroblast to fulfill these cellular processes.

Even in non-muscle cells, the architecture of the cytoskeleton is specialised for force generation and sensing. The organisation of the cytoskeleton in non-muscle cells is strikingly similar to that in muscle cells. In both cases contractile and elastic forces are integral in establishing a functional cytoskeleton, and once formed, a pattern of repeating protein-based contractile proteins becomes evident. However, unlike in muscle cells, these structures continuously assemble and disassemble in non-muscle cells, allowing them to adapt their function, shape, and direction of movement according to the environment they find themselves in.

As observed in this study, even non-muscle cells require the strength to pull against their surroundings, and fight their way through often sticky environments. This strength comes from a highly refined system of filaments and motor proteins. Although not as strong as those found in muscle cells, their organisation in non-muscle cells allows them to remain responsive to changes in the environment, whilst providing just the right amount of force to carry out their functions.

Explore further: Cellular podiatry understanding how cells form feet

More information: Shiqiong Hu et al. Long-range self-organization of cytoskeletal myosin II filament stacks, Nature Cell Biology (2017). DOI: 10.1038/ncb3466

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How non-muscle cells find the strength to move - Phys.org - Phys.Org

European Patent Office to grant UC a broad patent on CRISPR-Cas9 – UC Berkeley

The European Patent Office (EPO) has announced its intention to grant a broad patent for the revolutionary CRISPR-Cas9 gene-editing technology to the University of California, the University of Vienna and Emmanuelle Charpentier.

A model of the Cas9 protein cutting a double-stranded piece of DNA.

The university is thrilled with this important EPO decision, which recognizes the pioneering work of Jennifer Doudna, Emmanuelle Charpentier and their teams as the CRISPR-Cas9 inventors, and also recognizes that the original patent application covers a wide range of cell types, including human cells, said Edward Penhoet, who was recently appointed a special advisor on CRISPR to the UC president and UC Berkeley chancellor. Penhoet, the cofounder and former CEO of Chiron Corp., is the associate dean of biology at UC Berkeley and a professor emeritus of molecular and cell biology.

The EPO patent will cover the single-guide CRISPR-Cas9 technology in cells of all types. The technology was invented by Jennifer Doudna, a UC Berkeley professor of molecular and cell biology, Charpentier, now director of the Max Planck Institute for Infection Biology in Berlin, and their colleagues. Applications include treatment of various human diseases, as well as veterinary, agricultural and other biotech applications. The European patent would cover some 40 countries, including France, Germany, Italy, Spain, the Netherlands and Switzerland.

The EPO has stated its intent to grant a patent with claims that encompass all cells, despite objections from third parties, including the Broad Institute, a joint research institute of Harvard University and the Massachusetts Institute of Technology.

We are excited that this patent will issue based on the foundational research we published with Emmanuelle Charpentier and the rest of our team. We look forward to the continued applications of gene-editing technology to solve problems in human health and agriculture, said Doudna, who is a Howard Hughes Medical investigator at UC Berkeley.

The CRISPR-Cas9 tool allows the precise editing of genes, and has been used in thousands of laboratories around the world to target and cut desired sequences of DNA, analogous to cutting and pasting letters or words with a word processor. This technology has already revolutionized the study of genetic diseases, and has spawned promising new therapies for blood diseases, AIDS and cancer.

What is CRISPR-Cas9 and how does it work? How do we edit genes? Jennifer Doudna, biochemist at UC Berkeley, explains (UC Berkeley video by Roxanne Makasdjian and Stephen McNally)

The EPOs notice of intent to issue the patent, as well as the UK Intellectual Property Offices grant of two similarly broad patents, are precedents for Doudna and Charpentier to receive wide-ranging patents in many countries, since many look to EPO and UK decisions for guidance in granting patents.

The UC patent application to the EPO was substantially the same as the UC patent application filed in the United States. In the U.S., UC claims covering the use of single-guide CRISPR-Cas9 technology in any setting were found to be allowable by the U.S. Patent & Trademark Office, and were placed in an interference with patents owned by the Broad Institute that cover use of the technology in eukaryotic cells. An interference is a formal legal proceeding before the Patent Trial and Appeal Board (PTAB) to determine who was the first to invent.

In a February ruling, the PTAB terminated the interference between the UC application and Broad patents, determining that the claims of the two parties did not constitute the same invention and, accordingly, the PTAB did not determine which party first invented the use of the technology in eukaryotic cells.

We disagree with the recent PTAB decision to terminate the interference between claims of the UC and the Broad Institute, and we are keeping all of our options open, including the possibility of an appeal, Penhoet said. We remain confident that when the inventorship question is finally answered, the Doudna and Charpentier teams will prevail.

The inventors listed on the European patent are Doudna; Charpentier; Martin Jinek, now at the University of Zurich; Krzysztof Chylinski of the University of Vienna; Wendell Lim of UC San Francisco; Lei Stanley Qi, now at Stanford University; and Jamie Cate, a UC Berkeley professor of molecular and cell biology.

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European Patent Office to grant UC a broad patent on CRISPR-Cas9 - UC Berkeley