Researchers take important step forward in disabling cancer cells … – News-Medical.net

March 10, 2017 at 1:38 PM

Recent study out of the University of Ottawa opens door for new disease therapies in cancer, ALS, Fragile X Syndrome and others.

Part of what makes cancer cells so devastating is their ability to fight back against treatments -- sometimes they work, sometimes they don't. But what if we could take away cancer cells' defences altogether?

Researchers from the University of Ottawa have taken an important step forward to doing just that. Dr. Kristin Baetz says the results of a three-way research collaboration could open doors to new therapeutics to treat a variety of diseases, including cancer.

Dr. Baetz is an associate professor at uOttawa's Faculty of Medicine and Director of the Ottawa Institute of Systems Biology. Her lab studies stress granules (SGs), which are structures produced by the body's cells to protect against environmental stressors. Unfortunately, SGs also help cancer cells defend themselves against chemotherapeutic treatments, which can then lead to resistance to the common therapy.

"The first step in figuring out how to prevent this from happening is to understand how stress granules are formed and disassembled," explains Dr. Baetz, "and we now have key information."

Using yeast cells, her lab has identified a class of enzymes that play an active role in regulating SG formation. Deactivating this class of enzyme has a direct correlation to lowering SG levels.

Yeast cells are a highly relevant source of information about human cells as they mimic human cell biology.

"On the surface we may be very different, but at the cellular level humans and yeast are very much the same," says Dr. Baetz. "Given that similarity, our research is of direct relevance to human cancer biology, and metabolic and neurodegenerative diseases."

The findings come at an opportune time, when a new group of drugs are being developed against these enzymes. When administered to the yeast cells, Dr. Baetz found, the new drugs were successful in lowering SG production.

Through collaboration with labs of mammalian cell biologists and cancer specialists, the team applied their findings from yeast cells to a breast cancer cell line -- and again showed the drugs had the effect of reducing SGs.

"We've discovered one way to decrease stress granule formation, plus we have therapeutics -- so we're well positioned to explore how this strategy might work on diseases," Dr. Baetz says.

The research collaboration between the three labs has led to a paper being published in PLOS Genetics. The paper highlights the research efforts of the labs of Dr. Baetz, professor Jocelyn Ct, and assistant professor Morgan Fullerton, all of uOttawa's Faculty of Medicine.

Dr. Baetz anticipates her team's work may lead to many new avenues of research, and is optimistic with regards to the fight to disarm the warriors that are cancer cells.

Originally posted here:
Researchers take important step forward in disabling cancer cells ... - News-Medical.net

Researchers discover intestinal quiescent stem cells that are resistant to chemotherapy – News-Medical.net

March 10, 2017 at 7:49 PM

The intestine has a high rate of cellular regeneration due to the wear and tear originated by its function degrading and absorbing nutrients and eliminating waste. The entire cell wall is renewed once a week approximately. This explains why the intestine holds a large number of stem cells in constant division, thereby producing new cell populations of the various types present in this organ.

Researchers at the Institute for Research in Biomedicine (IRB Barcelona) headed by ICREA investigator Eduard Batlle, head of the Colorectal Cancer Laboratory, have discovered a new group of intestinal stem cells with very different characteristics to those of the abundant and active stem cells already known in this organ. Performed in collaboration with the Centro Nacional de Anlisis Genmico (CNAG-CRG), the study has been published in Cell Stem Cell. These new group of stem cells are quiescent, that is to say, they do not proliferate and are apparently dormant.

The researchers describe them as a reservoir of stem cells--it is estimated that there is one quiescent cell for every 10 active intestinal stem cells. In healthy conditions, these cells have no apparent relevant function. However, they are important in situations of stress, , for example, after chemotherapy, in inflammatory processes, and in tissue infections--all conditions in which the population of "normal/active" stem cells is depleted. These quiescent cells would serve to regenerate the organ by giving rise to the various types of cells present in the intestine, renewing the population of "normal/active" stem cells, and restoring balance to the tissue.

Eduard Batlle explains that the discovery of quiescent stem cells in the intestine reveals that stem cell biology is more complex that previously appreciated and that it does not follow ahierarchical model of cell organisation. "In intestinal cell hierarchy, there are no cells above others, so the two populations are in a continual balance to ensure the proper function of the organ".

Most drugs against cancer have a secondary effect on the cells that are dividing in our tissues. "Because quiescent stem cells divide infrequently, they are resistant to many types of chemotherapy and they regenerate the tissue that this treatment has damaged," explains Eduard Batlle, head of one of the labs of international prestige in research into intestinal stem cells and their involvement in colorectal cancer.

Quiescent cells are present in many kinds of tissue. However, in spite of their relevance in tissue regeneration, increasing evidence points to their involvement in tumour development. "It is difficult to study these cells, mainly because they are scarce and there are technical limitations with respect to monitoring, straining and distinguishing them from the others," explains Francisco Barriga, first author of the study and current postdoctoral fellow at the Memorial Sloan Kettering Cancer Center in New York.

Using advanced techniques, such as genetic tracing of cell lineages and transcriptomic analysis of individual cells, performed by CNAG-CRG and the Bioinformatics and Biostatistics Unit at IRB Barcelona, the group has identified the distinct genetic programme used by quiescent stem cells with respect to normal intestinal ones. This work has been done over six years.

The researchers have labelled this cell population with a specific marker, the Mex3a protein, which has allowed them to track it over time. "We intend to continue studying quiescent stem cells in health and disease and to discover the function of the genes that distinguish them in the colon and in other organs," says Batlle.

Read more from the original source:
Researchers discover intestinal quiescent stem cells that are resistant to chemotherapy - News-Medical.net

Anatomy of a North Korean Assassination – Daily Beast

Put aside for a moment the geopolitical implications. How did the assassins evidently sent by North Koreas Kim Jong Un to murder his half brother get the job done?

BANGKOKOne by one, on different flights at different times, four men from North Korea flew into Malaysia over the course of a fortnight in February, coming together finally in a condo apartment on Kuchai Lama Street in a bustling middle-class suburb on the edge of the countrys sprawling capital, Kuala Lumpur. According to multiple reports, after the murder and at the height of the scandal, they huddled frequently with Ri Jong Chol, a 47-year-old North Korean who holds a science degree and who moved to Malaysia in August 2016.

Ri worked for an outfit called Tombo Enterprises. According to its web site it makes anti-cancer supplements and emphasizes wholesome treatment built around herbal medicines. But Ri may have been more useful to the new arrivals for a particular set of skills: handling and combining the binary components of the deadly nerve agent VX, the weapon of mass destruction that would be used to kill Kim Jong Nam, estranged older half-brother of North Korean dictator Kim Jong Un.

VX, which is outlawed around the world by signatories of the Chemical Weapons Convention, is a slightly yellow liquid with no smell and no taste When its dispersed as an aerosol, victims do not know they have been affected until they begin to die, quickly and horribly, more or less like flies zapped with bug spray, choking, twisting and kicking as their nervous system shuts down. In one infamous incident at the Dugway Proving Grounds in Utah in 1968 more than 4,000 sheep were killed by accident some 30 miles from the test site.

But how do you handle such dangerous stuff, using it to kill one man instead of a whole crowd, especially if your best shot at that man is likely to be in a public place?

That would require two hands at a minimum, or better yet, two people. Then the question would be, who could approach the pudgy playboy Kim Jong Nam while raising the least suspicion?

Its not clear how the four men on Kuchai Lama street hooked up with two young women called Siti Aisyah and Doan Thi Huong, both of whom have been arrested, both of whom have said they are innocent, and both of whom face the death penalty if convicted.

Siti, an Indonesian in her twenties, had been working as a masseuse and nightclub hostess, and reportedly was out partying with friends the night before the slaying. Doan, 28, is a Vietnamese who flew into Kuala Lumpur from Hanoi on February 4. She also had been working as a hostess. On her Facebook page she posted under the name Ruby Ruby.

But the more details are revealed about their backgrounds, the murkier those become.

Citing travel documents she was carrying when arrested, Malaysian police identified the Indonesian as Siti Aisyah, of Serang, the capital of Indonesias Banten province. But Indonesian-language web sites suggest she is from the village of Angke, near Jakarta, and that there are two listings for her there: one indeed identifies her as entrepreneur Siti Aisyah, 25; the other says she is housewife Siti Aisah and that she is 27.

Indonesians do not typically have two ID documents.

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One site says Siti is divorced from an Indonesian man and has a 7-year-old son she rarely sees. She was married when she moved to Malaysia in 2013, one site said, but subsequently split from her husband.

She reportedly met the man, or men, who hired her for the Kim Jong Nam hit at a nightclub where she works in Kuala Lumpur. Local reports say she told police the men she met looked Korean or Japanese.

Broadcast reports say Doan Thi Huong is an aspiring singer who competed onVietnam Idol, her countrys version of the global Idol franchise. A video of the program shows a woman apparently auditioning who looks remarkably like Doan. She sings for just a few seconds before one of the three judges interrupts her and says, OK,a dismissal. She also says OK, and bows demurely. But the contestants name thats flashed on the screen is Dinh Thi Khuyen, not Doan Thi Huong.

A Facebook page attributed to Doan, which includes a couple of dozen Korean-sounding names among her friends, shows several photos of a woman with dyed reddish hair dressed provocatively. In one she wears a very fitted cheongsam, the classic one-piece Chinese dress, and in another shes sporting a red one-piece swimsuit. She is also pictured wearing a white, long-sleeved t-shirt emblazoned with the letters LOL.

Malaysian authorities say that prior to the incident at the airport, Siti and Doan staged a couple of practice runs, moving in on hapless victims at shopping malls with what presumably were benign chemicals or none at all.

On the morning of February 13, police say, Siti and Doan entered Kuala Lumpur International Airport Terminal 2, known as KLIA2. Its the home base of Air Asia, one of the worlds most successful low-cost carriers, and at any given time its likely to be full of holidaymakers and business people on a budget. It would have been teeming with backpackers, tour groups and adventure seekers, the departure area full of people waiting to board flights.

What grainy CCTV video shows from February 13 is a portly man subsequently identified as Kim Jong Nam wearing a light blue suit and carrying a medium-sized bag on one shoulder. Suddenly, a woman rushes up behind him and forcefully throws both arms around his neck as if to restrain him. Then a second woman comes up to him from the front and puts somethingperhaps a rag or tissue paperin his face. It all happens very quickly, and there appears to be little commotion around the heavy-set tourist and the women, who briskly walk away after attacking him.

One of the women, apparently the one who approached from behind, was wearing a white long-sleeved t-shirt. Another surveillance camera caught a clearer picture of her. The letters LOL were emblazoned across the front of the shirt.

The 45-year-old Kim Jong Nam has known for years that his 33-year-old half-brother, Kim Jong Un, the worlds most dangerous nuclear-armed dictator, wanted him dead. Jong Nam had questioned the right of his family to heredity rule, and there was a reported attempt on is life in 2011. But for years Jong Nam has lived in Macau under the protection of the Chinese, who may have deemed it wise to hold him in reserve as an alternative or at least an implied threat to their impetuous young client in Pyongyang.

Jong Nam has always been restless. He once famously got caught trying to visit Disneyland Japan using fake papers. In Kuala Lumpur, he was traveling on a passport under the name Kim Chol and posing as a businessman. He apparently believed that by traveling incognito on a low-cost carrier he could dispense with a phalanx of bodyguards.

Almost immediately after the LOL woman and her accomplice carried out their attack, police said, Jong Nam rushed toward employees at a nearby help desk, gesturing at his face, telling them he could not breathe well. First-aid workers soon placed him on a stretcher, police said, and as Jong Nam began to choke, the emergency crew left with the stricken victim, heading toward a nearby hospital. But he died in agony on the way, less than 20 minutes after he first ingested the poison.

At a news conference, Malaysian Health Minister Subramaniam Sathasivam said, VX only requires 10 milligrams to be absorbed into the system to be lethal, so I presume that the amount of dose that went in is more than that. If he inhaled the substance, or it went in through his tear ducts, a smaller quantity might have sufficed. But in any case, The doses were so high and it did it so fast and all over the body, said the minister. So it would have affected his heart, it would have affected his lungs, it would have affected everything.

Malaysia promptly launched an investigation, ordering an autopsy of Jong Namover the objections of North Korea, which demanded the bodys immediate release, and accused the police of desecrating the remains of a citizen of the so-called Democratic Peoples Republic of Korea.

Kang Chol, the countrys ambassador to Malaysia, declared that the North had nothing to do with the death of that citizento whom he doggedly referred as Kim Chol.

South Korean Acting President Hwang Kyo-Ahn decried the killing as an intolerable crime against humanity and terrorist act. In Seoul, government elements told reporters they believed the plot was hatched and carried out by North Koreas foreign and security ministries.

Malaysia accused the plotters of endangering the lives of thousands of passengers by exposing them to a weapon of mass destruction. Luckily, a hazmat sweep found no evidence of VX contamination at the airport, which quickly went back into service.

On the outskirts of Kuala Lumpur, the hit squad abandoned the safe house on February13. At least three of the men fled to neighboring Indonesia: Hong Song-Hac, Ri-Ji-Hyon and Ri Jae-Nam boarded Emirates Flight EK0359 at 10:20 p.m. local time bound for Dubai. No one knows how the fourth, O Jong-Gil, got out of Malaysia, but it appears he is gone, too. All are said to have returned to Pyongyang on February 17, presumably to the huzzahs of the increasingly paranoid, erratic, and murderous Kim Jong-Un, who recently ordered the executionby anti-aircraft gunsof five senior officials who made supposedly false reports that enraged the young tyrant.

Not all members of the black op got away in the initial police roundup. In addition to the women, police held Ri Jong-Chol, the medicine-manufacturer employee, but subsequently released him. He gave a press statement in front of the North Korean embassy in China protesting his innocence.

Malaysian authorities believe at least seven North Koreans were involved in the attack. One person they want to question is North Korean embassy Second Secretary Hyon Kwang-Song, who some believe ran the operation from his office. Because of diplomatic immunity, Hyon would have to consent to an interrogationwhich isnt going to happen.

Police also would like to interview Kim Uk-Il, an employee of the Norths flag carrier Air Koryo, who apparently was at the airport when Jong Nam was killedand also is believed to be hiding out in the embassy.

One of the women, Siti, has told authorities her recruiters told her she would be playing a practical joke on a businessman for a TV show, claiming she was paid $90 for tossing some baby oil on the mans face. But National Police Chief Khalid Abu Bakar has said the woman seen on video daubing VX on Jong Nams face clearly knew she was carrying out an attack, not some reality TV stunt. And the womens claims dont explain why they rushed to wash their hands after the incident. Nor why theyre still alive.

Siti vomited after she was nabbed by police, but both women should have been severely injuredif not killedthrough close contact with the VX. That they were not has led police to question whether their handlers gave them atropine, an antidote for the WMD.

Did the four men smuggle VX or its components into Malaysia? Did their local contact help mix it right there in Kuala Lumpur, or show the women how to combine the elements on Jong Nams face? Was it brought in through North Korean official channels, perhaps in diplomatic mail that is not subject to normal customs procedures? And was the whole affair coordinated by North Koreas shadowy spy agency the RGB (Reconnaissance General Bureau)?

It is very likely that the VX was smuggled into Malaysia either in person or as cargo, says Rohan Gunaratna, head of the International Centre for Political Violence and Terrorism Research in Singapore. There is also a possibility that the North Korean embassy smuggled it in by diplomatic pouch.

A few days after the murder, Pyongyang sent a high-level delegation to Malaysia for talks aimed at claiming the body of Kim Jong-Nam/Kim Chol, and springing Ri Jong-Chol. Group spokesman Ri Tong-Il told reporters the envoys also wanted to further develop friendly relations between the two governments. The two countries had enjoyed reciprocal visa-free travel, although mutual trade amounts to less than $10 million. Pyongyang had seen Malaysia mostly as an entry point into Southeast Asiaa region the North wants to be friends with as a means of countering Seoul.

But improved relations now seem unlikely, even impossible. Both countries have been lobbing angry accusations at each other, including a blast from Pyongyang that KLs investigation has been awash in weak points and contradictions. The Malaysians recalled their ambassador from Pyongyang, and are said to be even more suspicious since someone apparently tried to break into the morgue where Jong Nams body was eld.

Pyongyang was not getting any love from China either. China is unlikely to abandon its protg any time soon, but theres no question Beijings patience is wearing thin as his behavior gets weirder.

A video surfaced earlier this week in which a young man who says he is Kim Jong Nams son tells the camera he is with his mother and sister and concludes, We hope this gets better soon.

Siti and Doan will next appear on April 13, when prosecutors will ask that they be tried jointly in a higher court. At the request of defense lawyers, the judge slapped a gag order on the case, the better to protect the womens rights and their prospects for a fair trial. Expect frequent leakage.

Christopher Dickey also contributed reporting to this story.

See the article here:
Anatomy of a North Korean Assassination - Daily Beast

Anatomy of a masterpiece: 13 reasons why the ‘funniest video of the year’ is pure comedy gold – Telegraph.co.uk

13. The off-camera action

The stage has emptied of three of its players, but that's not to say they've left our mind. Just as you start to imagine the rollicking now being dished out, a child's wail can be heard from behind the wall (O:38in the video). Those kids are suffering for the art they've given us and still Prof Kelly goes on, professional to the end, talking aboutNorth Korea and VX gas and things that surely are not at the forefront of his mind right now.

We salute you, Mr Kelly, and offer astanding ovation to your family. And we hope you understand, as laughter ricochets around the internet, that our joy is not mean-spirited. We're laughing because we can see on screen a reflection of our own families, in all their hilariouschaoticbrilliance.

Perhaps Homer Simpson put it best."It's funny," said the father-of-three, "because it's true."

Excerpt from:
Anatomy of a masterpiece: 13 reasons why the 'funniest video of the year' is pure comedy gold - Telegraph.co.uk

Grey’s Anatomy Recap: Mommy Issues – Vulture

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,*zj"i`O ;:Jh_7u2YK&73Sgdyv C=mVbQ8'.0K^{$qdx/ Qr=Jc;n193#7c*PAq0.Riy5_!8-sc4u,{L2DYKJ$v6eSh-q?FiVaH{CKql>OYxq!Asq `X$-Ey9R^^gw)A;N[1`Pb("{|{^bz-PirzP.tGCp5QI62eQ*Nx"$7FL]R2Nf VB{7Xx*7@"<2DbY:c>~/Z#,EYTo i~nQlCdv S4<2@/3 QnzHVOL]^a>2*TSjk_("y UH zA!W [H$,4c&Kv}qL$%E3 IkKwO^9g^Sz}rx}TQ'2$DO0L='Z*EaQJVGPJ~94M=>(uUg 865[YNOT0S7}wVpXi;V1kG>rL#1'_K]*KxQ=^8W/c"'/wxef@H#$U=D -5zs&5V8_0O{qT@~9%>/^lLS]U6VM Kw5p |cs#lqa,K1m_Y7*9B?RvSbKc$S|PG`:!XQ.V'E,_xwWO%Zy~g}.%QJH<]~??)?8ylU exw&+3gHh[*ooX?8`w%YQ_w: ^

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Grey's Anatomy Recap: Mommy Issues - Vulture

‘Grey’s Anatomy’ Fans Weren’t Pleased With That McDreamy Scene in the Latest Episode: Here’s Why – Us Weekly

Breaking our hearts (again). Meredith Grey (Ellen Pompeo) looked back on the death of Derek Shepherd (Patrick Dempsey) on the most recent episode of Greys Anatomy, and not all viewers were delighted to hear his name mentioned.

Fans seem to have a love-hate relationship with the show bringing up Derek. On one hand, everybody loves remembering the good ol' days of McDreamys time at Grey Sloan. However, some devotees seem to feel that whenever they are almost over the character's death, series creator Shonda Rhimes decides to make them relive the terrible moment over and over again.

Riggs Remembers

During the Thursday, February 23, episode, a schizophrenic patient who was missing from her parents for more than a decade was reunited with them at the hospital. The parents even had a funeral for their daughter after she vanished because they assumed she was gone for good. However, rather than empathizing with the parents, Nathan Riggs (Martin Henderson) thought they lost faith in finding their child.

They gave up on her, Riggs said to Maggie Pierce (Kelly McCreary). They will never forgive themselves. The ordeal apparently reminded him of fiance Megan Hunt (Bridget Regan), who went missing in a helicopter and was never found.

Meredith Talks McDreamy

Pierces conversation with Riggs was tough for her, so she decided to talk to Meredith about the experience. The women spoke about how they cant imagine what Riggs must feel every day when he thinks about Megan's possible whereabouts. Meredith said she could relate to Riggs because she felt a similar way after McDreamys death.

When Derek died, there was one day where I didnt know where he was, Meredith said. I pretended everything was going to be OK, but inside, I was going crazy. I guess its like that for Nathan every day.

Check out what fans were saying on Twitter about the brief mention of McDreamy.

Grey's Anatomy airs on ABC Thursdays at 8 p.m. ET.

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Originally posted here:
'Grey's Anatomy' Fans Weren't Pleased With That McDreamy Scene in the Latest Episode: Here's Why - Us Weekly

Grey’s Anatomy’s Kevin McKidd Has a Grim Warning About Owen … – E! Online

Could Owen Hunt be on his way to his second divorce on Grey's Anatomy?

When season 13 began, we had such high hopes for newlyweds Owen and Amelia, but like all hope in Shondaland, it quickly dissipated to the point that they aren't even sleeping under the same roof anymore, let alone speaking. And as Kevin McKidd tells us, this very well could be the end of the road for the couple.

"It's a hard one because she's got all these demons. He does too. And now they've hit against this big issue of the baby. Owen has always imagined having a family, and now she seems to be changing her view on that. So that's going to be a big issue for them," the actor told E! News during a recent visit to the Grey's set. "I'll be interested to see what happens, but, at the moment, it's not looking good. I have to say, it's not looking good. But sometimes that's what's so interesting about the show and I think what's clever about the show is that it looks like the story's pulling you in one direction and one thing will happen and it will change everything."

ABC

But before you give up on Owen and Amelia completely, know that McKidd isn't ready to throw in the towel just yet. "I've got a feeling that Amelia's going to sort of come to Owen's rescue somehow," he admitted. "I don't know why I think that. It's just a gut feeling I have."

Whatever happens, look for some movement on that front beginning with tonight's episode, when Amelia (Caterina Scorsone) finally faces her feelings about her estranged husband.

Speaking of estrangement, when we sat down with McKidd we couldn't resist the opportunity to test him on the fan theory out there that his presumed dead sister Meganwho we met in this season's flashback-laden episode "The Room Where It Happens," where she was played by Bridget Reganisn't actually all that dead. After all, this is Grey's. You don't usually hear about a family member if they're not going to make their way to Grey Sloan Memorial in some way,shape or form.

So, could McKidd shed any light on the theory? After a long pause wherein he seemed to be very carefully crafting his response, he said,"I can't. Listen, on any ABC Shondaland show, there's always a maybe to everything. Anything can happen. I've got to say, the actress who played her in the flashback episode is brilliant and we had great chemistry and we got along really well. So, if that happened, I'd be very delighted about it."

For more from McKidd, including why he's hoping for a visit from former co-star Sandra Oh, be sure to check out the video above.

Are you still holding out hope for Owen and Amelia? And do you buy into the theory that Megan just might be alive? Share your thoughts in the comments below!

Grey's Anatomy airs Thursdays at 8 p.m. on ABC.

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Grey's Anatomy's Kevin McKidd Has a Grim Warning About Owen ... - E! Online

How an Atari Chip Set Off a War Among Neuroscientists – WIRED

Slide: 1 / of 1. Caption: Getty Images

This January, a video game chip started a scientific reckoning. It all began when some microchip archaeologists photographed the chipthe MOS 6502 microprocessor that lived inside Atariand built a digital model of its interconnections. Then some neuroscientists put it to the test. One by one, they knocked out the transistors in their map, trying to get at what the circuit was for. Its similar to what neuroscientists do when they lesion a part of the brain, or silence single neurons. Their project was simple: Could they use the arsenal of neuroscience methods to get at the function of a simple circuit?

They failed. Miserably. The scientists experiments didnt produce much information about Donkey Kong, Space Invaders, or Pitfalljust which transistors you could knock out and turn the game off. The result was damning for researchers pursuing the connectome, a bottom-up recreation of all the brains interconnections. To the neuroscience community, the message was clear: Brain scientists may have plenty of bottom-up data about the brain, but theyre far from using that data to understand how the organ works. For all of these approaches, we havent really thought through how to ultimately get at an understanding of the brain based on the data were getting, says Konrad Kording, a neuroscientist at Northwestern and one of the studys authors.

But even Kording thinks theres hope for the future of the connectome. It just isnt quite what people think.

To get a connectome, neuroscientists bounce beams of electrons off of neural tissue, creating nanoscale images of cell membranes and organellesin some cases, even little bubbles of neurotransmitters. Then they can trace the long, thin axons and dendrites, ultimately building a map of all their interconnections.

And just having the map isnt enough. For the microprocessor example, we know exactly how transistors behave, and we can simulate them, says Shawn Mikula, a neuroscientist at the Max Planck Institute for Neurobiology in Germany working toward a whole-brain connectome of the mouse. But for the cellular connectome, we dont know the individual properties of neurons very well. Neurons have complex electrical properties, and synapses that can be active or silent. They can also release different neurotransmitters onto many different types of receptors. Neurons, Mikula says, are worlds unto themselves.

But even if they could collect the data about all of that variationand both Mikula and Kording are skepticalits a big jump from a simulation to understanding the brain. Kording says that if he could give a colleague a hard disc with the whole human connectome on it right now, they wouldnt know what to do with it. The shocking thing is that even the brightest people I know in neuroscience just say, Well, someones going to figure it out. Neuroscientists want to figure out how neurons influence each other, gaining a broader understanding of how the brain computes. But his microprocessor paper suggests that, at least with the tools neuroscientists have now, that wouldnt be possible.

Mikulaalong with many in the fieldis less fatalistic. He actually uses the Atari microprocessor in his talks as an example of how bottom-up structure can be used to predict function. Because in the paper that was exactly what they did, Mikula says. They had a circuit structure and they ran simulations on it to determine the function. The paper was actually proving the point of connectomics. The functions were simpleon/off switches and clocksbut they still figured them out.

Just like Kordings experiments didnt get all the way to understanding the microprocessor, a connectome might not give you a perfect simulation of the brain. But it could simplify certain research problems in neuroscience. A neural map could constrain the problem of where a piece of information could go if, say, it came in to your brain through your eyesletting researchers trace the path through the maze of the brain. In Mikulas view, the connectome is a tool for asking questions about the brain, rather than the answer to the question of how the brain works.

The connectome could also clear up one area of neuroscience that desperately needs some structure: neuroanatomy. Classically, neuroscientists have used traces of different chemicals to parcel the brain out into little modules, like the dopamine-rich substantia nigra, which works to provide rewards. That way of thinking works pretty well for some brain areas, Mikula says, but when you get to more complex processing regions it starts to get a bit fuzzier. The connectome could fundamentally change how scientists talk about the brains structure. You can see whether it actually makes senses to talk about having discrete processing modules or discrete areas in the brain, says Mikula.

To really tap the potential of the connectome-as-tool, though, neuroscientists will need to figure out how to build them faster. Comparing multiple connectomes could help explain disease pathology or between-species differences in brainsbut right now, building just a single connectome is a huge endeavor. The most successful method involves imaging the top of a cube of brain, then slicing off a very thin layer with a diamond-tipped blade and imaging the next layer in the cube. The slices are destroyed in the process, so you only have one shot to get the images.

Mikula is one neuroscientist working to build connectomes faster. Hes developing a whole mouse brain on tape with software that can randomly access different parts of the brain and image at different resolutions. Neuroscientists could target certain parts of the brain at lower resolution and target high-priority spots for high-res imaging later. Eventually, it might be possible to label different chemicals in the cells on the tape as well to get at the functional differences between different types of cells. Mikula may never get to a whole-brain simulationbut that wont stop him from trying.

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How an Atari Chip Set Off a War Among Neuroscientists - WIRED

BPS sponsored symposium to take place at BNA 2017 Festival of Neuroscience – The British Psychological Society

A British Psychological Society (BPS) sponsored symposium on the social nature of humans will take place on Thursday 13 April at the British Neuroscience Associations (BNA) 2017 Festival of Neuroscience at the ICC in Birmingham.

As a partner society of the BNA, the BPS have sponsored an event entitled What is special about social? - a question that will be explored from four different perspectives by four guest speakers from universities across the UK.

Professor Bhismadev Chakrabarti, from the University of Reading, will chair the event and commented:

"What does it mean to be 'social'? How did 'social'-ness evolve? How do we study 'social' behaviour in a laboratory setting? These are some of the questions we hope to discuss at our symposium at the BNA Festival of Neuroscience.

Social behaviour lies at the heart of the human experience. Recent empirical efforts within psychology andneuroscience to understand processes in social behaviour have led to sub-disciplines such as social neuroscienceand social cognitive affective neuroscience. Despite the high levels of interest, the term 'social' continues to be ill-defined. Our symposium will systematically address this definitional question from evolutionary and developmental perspectives and use insights from individuals with and without psychopathological conditions marked by difficulties in social behaviour."

More information on the 2017 Festival of Neuroscience and details on how to attend can be found on the BNA website.

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BPS sponsored symposium to take place at BNA 2017 Festival of Neuroscience - The British Psychological Society

A New Era for Movement Brands: 6 Lessons from the Women’s March – Sustainable Brands

Januarys Womens March was one of the biggest global movements of recent years. An estimated 5 million people marched in 17 different countries to show their support for basic human rights - freedom, equality, justice and personal security - which are increasingly under threat across different areas of peoples lives.

It hasnt stopped there - the movement is maintaining its momentum: With 1.3 million hashtags posted to date and growing every day, the conversation is very much alive with its roadmap of 10 Actions in 100 Days, including the call for a day of action (A Day Without a Woman) to supportInternational Womens Day on 8th March. The effectiveness of such a mass follow-up will be revealed in the coming months as actions continue. Nevertheless, the impact of the movement to date provides many useful lessons for organizations or brands looking to engage people at scale.

It is incredible to think that this all started from just a single concerned person on Facebook (a retired grandmother in Hawaii). Some of the success of the movement clearly sprung from the way the 2016 U.S. presidential campaign galvanized the public and raised awareness of multiple threats to human rights issues threats that continue into the new administration. However, there are other fundamental factors that have driven the movements success. It understands that change is driven by action and that action (human behavior) is influenced by 2 questions:

1. How motivated am I to do this?

2. How easy is it for me to do this?

Both questions have an influence on our behavior at a personal, social and structural level. The Womens March movement has successfully influenced and encouraged its communitys behavior at all three levels. As brands increasingly become involved in or create campaigns focused on social issues, there is much that they can learn from the huge reach and depth of engagement generated by this particular movement.

1. Movements are the organizational expression of a shared personal belief

Brands need to be clear about the core human value used to inspire individuals to take action. Despite the complex mix of issues - including gender, race, economics, age, health and representation - what the leaders of the movement did well was to define the core issue that they were fighting at the most fundamental human level. This was about social (or human) rights - an issue that matters to many (hopefully all) people. At the heart of this is a fight against the exclusion and divisions which pose an ever-increasing threat to our world, and the livelihoods of minorities in particular. From the title of the initial action - a March for All - to the lengths that the leaders of the movement went to make it clear that this was a movement for all (black women, LGBT women, disabled women, girls as the next generation and men and boys), it was clear that this community was living up to its core beliefs and values. The movement grew its potential scale during this time by incorporating and welcoming many different groups. By taking care to clarify the specific goals and actions of the movement, they were able to structure their fight in a way that delivered scale (inclusion of many) but with chunk-sized deliverables. Rather than boiling an ocean, they were tackling lake-sized challenges.

This is an approach that others have successfully adopted, most notably Ben & Jerrys, whose broad fight for social justice addresses the different pillars of the environment, people and communities, economic and peace. Furthermore, individual campaigns have tackled specific fights such as climate change, marriage equality and political lobbying. Social justice is a very clear and strong ideal and identity for people to buy into. It allows communities to get involved in supporting a wide range of causes that are relevant to their core shared belief.

Both of these examples demonstrate that if you build your movement on large-scale, fundamental human values, many people will be personally motivated to build scale for impact.

2. Make it easy for individuals to contribute in significant ways

Low cost of entry = high level of commitment. Joining a social fight in a significant way can seem a pretty daunting task to most people. To make a real commitment (beyond small tokenism) suggests real effort both literally and emotionally. So, getting the balance right is not easy. We want to encourage actions with sufficient weight to signal a strength of feeling and support that are able to have an impact on those we want to sit up and take notice, without these actions being so onerous or tough that they are never performed. It is best to make it easy for those people whose behavior we want to influence. The actions that the Womens March required came with lots of support, advice and tools to make it easier to put them into practice. These ease-of-use elements included simple templates to create content, existing posts that could simply be reposted, instructions for how to organize transport to marches, etc.

Whilst the actions were often simple to execute, they were all significant in their impact as they were clear and public expressions of peoples support for the movement and anger at the issues. Whether participants created posts on social media or joined the physical marches, they publicly committed to the cause. These tangible and visible actions were performances that, when delivered by 5 million people, were a clear sign of strength of feeling and commitment.

The movement made it easy for people to participate on a personal level, and to realize that they could do it. The low cost of entry made it easy for as many people as possible to join the fight.

3. The most solid and authentic foundations for a movement are found at a local level

Look for opportunities to build from existing community-based groups and leverage their existing social ties. The Womens March movement was not created by a big launch and top-down approach. Instead, it was built bottom-up, around real people and their existing grassroots communities. This gave the movement a huge amount of authenticity but also provided a large amount of the social motivation and influence that drove so much of the action. As people, we place significant value on our social ties. Our desire to be part of the group - and to be seen to contribute positively to that group by supporting its values and the people within it - means that peer pressure can be even more powerful than personal motivation. We do not want to let others down; if they are showing commitment, we feel that we must do so as well. In this contentious political time, many have expressed their points of view solely via social media. As members of their social group began to step forward and make commitments to a point of action by joining the march, the rest of that group felt compelled by social pressure to do so as well. There was often a very powerful social network multiplier at work.

This is a key lesson for building movements at scale. If you want to influence individuals, the most powerful way to do so may be to influence their social networks. It creates a situation where at a social level, many people feel compelled to say I want to do this.

4. We are creatures of habit, so make it fit around peoples lives and social structure

Build your brand movement and activities around existing social infrastructure and habits. Using local groups and movements as the foundation for the organization made it easy (and natural) for the Womens March to generate actions. The movement was built around existing relationships and the associated social infrastructure, which created a friendly, open and positive vibe. Members could largely continue operating within existing local groups, now simply connected to a bigger network of activists who shared common values and concerns at the broader level. Recruiting new people to the movement was conducted through known local networks and figureheads. Strong existing social bonds and relationships were maintained, creating a real sense of warmth and familiarity to this movement that made it feel easy and comfortable for people to join and participate.

Using peoples existing social ties and habits these makes it easy for people to realize they can contribute to the cause within the bounds of their existing, natural behaviours.

5. Reward people for the right behaviors

The carrot and stick approach may seem somewhat old fashioned but it still works in todays world. Rewards plus fun can be a strong combination: Applying a layer of gamification, especially linked to social networks and apps, can be a great way to drive the desired behaviors and actions. Interestingly, to date, it hasnt been a big feature of the Womens March movement but that may simply be a reflection of the strength of feelings already at work the strength of the personal and social motivations makes incentives unnecessary. But if the momentum slows, it could be a useful additional element to add to the other strategies. There may come a time when the movement needs to give its community more reasons to want to participate in the next series of actions.

6. Facebook is for more than sharing funny animal videos

At a structural level, the movement made it easy for the community to connect, organize and take action by leveraging the scale and power of digital social networks. Facebook (including Facebook Events) and Twitter were the primary tools, supported by an app that, as well as providing a portal to each network, included all of the basic information on the movement (the goals, details on the actions, a timetable of events, partners, how to donate, etc.). In the modern world of movements, digital social technology has transformed the ability of people to organize and act at scale. As this example shows, one grandmother in Hawaii supported by a Facebook-based infrastructure can create a lot of impact!

The fundamental variables to a successful movement can be summed up in a very simple equation: More people x more actions = more impact. This seems like a logical equation, but it is in fact about applying human logic to find the optimal solution. Designing your movement in such a way that you maximize the motivation to participate and minimize the barriers to entry will increase the likelihood of success. By deploying human sense, the Womens March created a movement that people wanted to be part of and could easily support through meaningful actions.

So, to maximize engagement at scale for your social purpose initiatives, consider the following checklist to give your campaign enough human relevance to motivate and inspire action from the people at the heart of your movement:

If you, too, are inspired, as we are, by the Womens March Movement, download our latest e-book, Beyond the Powergirl. Our contribution to the cause of gender equality, it helps brands and organizations to imagine the many positive female identities, qualities and values that can be unlocked in a future where women feel free to express and share their full capacities in society. Play our Tribal Game to discover your own future female identity.

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A New Era for Movement Brands: 6 Lessons from the Women's March - Sustainable Brands