Cell Biology – thoughtco.com

What Is Cell Biology?

Cell biology is the subdiscipline of biology that studies the basic unit of life, the cell. It deals with all aspects of the cell including cell anatomy, cell division (mitosis and meiosis), and cell processes includingcell respiration, and cell death. Cell biology does not stand alone as a discipline but is closely related to other areas of biology such as genetics, molecular biology, and biochemistry.

Based on one of the basic principles of biology, the cell theory, the study of cells would not have been possible without the invention of the microscope. With the advanced microscopes of today, such as the Scanning Electron Microscope and Transmission Electron Microscope, cell biologists are able to obtain detailed images of the smallest of cell structures and organelles.

All living organisms are composed of cells. Some organisms are comprised of cells that number in the trillions. There are two primary types of cells: eukaryotic and prokaryotic cells. Eukaryotic cells have a defined nucleus, while the prokaryotic nucleus is not defined or contained within a membrane. While all organisms are composed of cells, these cells differ among organisms. Some of these differing characteristics include cell structure, size, shape, and organelle content. For example, animal cells, bacterial cells, and plant cells have similarities, but they are also noticeably different.

Cells have different methods of reproduction. Some of these methods include: binary fission, mitosis, and meiosis. Cells house an organisms genetic material (DNA), which provides instructions for all cellular activity.

Cell movement is necessary for a number of cell functions to occur.

Some of these functions include cell division, cell shape determination, fighting off infectious agents and tissue repair. Internal cell movement is needed to transport substances into and out of a cell, as well as to move organelles during cell division.

Study in the field of cell biology can lead to various career paths. Many cell biologists are research scientists who work in industrial or academic laboratories. Other opportunities include:

There have been several significant events throughout history that have led to the development of the field of cell biology as it exists today. Below are a few of these major events:

The human body has a multitude of different types of cells. These cells differ in structure and function and are suited for the roles they fulfill in the body. Examples of cells in the body include: stem cells, sex cells, blood cells, fat cells and cancer cells.

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Cut the long story short, and stitch it back together – Science Daily

A species of unicellular ciliate has found a special trick to make use of the cellular machinery in seemingly impossible ways. Researchers of the NCCR "RNA & Disease -- The Role of RNA Biology in Disease Mechanisms" of the University of Bern have for the first time described a mechanism in detail how so called "junk"-DNA is transcribed before being degraded -- and this mechanism is remarkably clever.

It sounds a bit like the winning proposal in a design contest: How can small pieces of information be read when they are too short to fit into the reading apparatus? Stitch them together into a longer string and close the string to produce a handy loop that can even be read off repeatedly. That's how a little organism called Paramecium tetraurelia, a species of unicellular ciliate, organises the transcription of small excised DNA segments into RNAs, which have a regulatory function.

But the story actually goes the other way round: When Mariusz Nowacki from the Institute of Cell Biology of the University of Bern found small RNAs with a regulatory function in the elimination of segments out of the Paramecium DNA, he and his team started to investigate the molecular mechanisms -- where do these RNAs come from, and what exactly is their role? They soon found out that there seems to be a sort of a feedback loop in the deletion of DNA segments. These, previously thought to be useless pieces of DNA (also called "junk DNA"), are cut out of the genome and then degraded by the cell machinery. However, before degradation, they serve as templates for small RNAs which in turn help with cutting out more of these DNA pieces. Once started, this pyramid system keeps reinforcing itself, via the production of RNA.

Transcribing the non-transcribable

As beautiful and intriguing as this system seemed to be, the researchers were left with a serious problem: Usually, the cellular transcription mechanism needs a much longer piece of DNA to operate. So how could these small excised DNA pieces -- of the length of not even 30 base pairs -- be used as templates? Without a good explanation for this, the whole theory looked very implausible. "It was an interesting detective work," Nowacki remembers. They had a suspect -- all they needed was to pin it down. "We were not actually looking for the unknown, because we soon had an idea, and then it was all about testing that idea." And their guess proved to be right: Paramecium has figured out a way to stitch DNA pieces together randomly into strings and, once the strings have the right length (of about 200 base pairs), to connect the ends and form circular concatemers of DNA segments.

Junk or not junk?

The finding has interesting implications: DNA thought to be non-coding "junk" -- of no use for the organism whatsoever and degraded quickly after being removed from the genome -, is actually a functional template for a biologically important class of small RNAs. It is actually one of the big emerging fields in molecular biology, whether "junk" DNA is really worthless or rather, as is increasingly becoming clear, whether it actually has regulatory functions. Nowacki believes that in this work his group was for the first time able to pin down a precise mechanism for the transcription of deleted "junk" DNA -- which would strengthen the case for an inevitable name change.

"RNA & Disease -- The Role of RNA Biology in Disease Mechanisms"

The NCCR "RNA & Disease -- The Role of RNA Biology in Disease Mechanisms" studies a class of molecules that has long been neglected: RNA (ribonucleic acid) is pivotal for many vital processes and much more complex than initially assumed. For instance, RNA defines the conditions, in a given cell, under which a given gene is or is not activated. If any part of this process of genetic regulation breaks down or does not run smoothly, this can cause heart disease, cancer, brain disease and metabolic disorders.The NCCR brings together Swiss research groups studying different aspects of RNA biology in various organisms such as yeast, plants, roundworms, mice and human cells. Home institutions are the University of Bern and the ETH Zurich.

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Cut the long story short, and stitch it back together - Science Daily

NASCAR Phoenix recap: The anatomy of Ryan Newman’s upset win – SB Nation

NASCARs version of March Madness didnt involve a buzzer-beater and a small school few recognized toppling one of college basketballs blueblood programs. Nevertheless what transpired Sunday at Phoenix International Raceway certainly qualifies as an upset, a reminder of what can transpire when circumstances converge resulting in an unforeseen outcome.

If prior to the Camping World 500 you were to draw up a list of potential winners, Ryan Newmans name certainly would not have been among the first dozen or so chosen. Thats what happens when you havent won in 127 races, while your team, Richard Childress Racing, has gone winless in the past 112 races with neither showing much indication of snapping their streaks of futility.

For much of Sunday, the fourth Monster Energy Cup Series played out as expected. Pole-sitter Joey Logano dominated early in winning the first stage, with promising second-year driver Chase Elliott asserting himself in the second stage. Then, Kyle Busch seized control in the decisive final stage.

At no point before the final two laps did it appear Newmans name would be etched on the winners trophy.

But the race that had seemingly been so clear-cut took an entirely different focus when Loganos overheated right-front tire exploded, sending him crashing into the outside Turn 1 wall with four laps remaining. This placed the crew chiefs for Busch and others running up front in a difficult position where they had to choose between pitting for fresh tires and foregoing track position, or staying out on older tires.

Newman, who was seventh, thought it best to pit and take two tires. Crew chief Luke Lambert thought otherwise. He wanted to go for the win, figuring that with so few laps left their best chance stood if they stayed out, thereby placing Newman in a position where he would need to play defense.

It was the only opportunity we had to win the race, Lambert said. I felt like doing it was going to yield a better result than the other option. Ultimately that was the decision. He said he could make the car wide. He did.

It was now Newmans race to win or lose. The key would be the restart. If he could get away cleanly and not have those behind on fresh tires get a run entering Turn 1, he stood a chance.

Newmans mind flashed back to late restart in last falls playoff race at Phoenix, when leader Matt Kenseth found himself in a similar position. On that day, Alex Bowman had been able to get to the inside of Kenseth, who came down and clipped Bowman sending him spinning. Logano would go on to win, while Kenseth not only lost the race but was also eliminated from the playoffs.

You're on old tires, it's easy to screw up, Newman said. You got to get your tires cleaned off right. You got to get a good launch. You got to run through the gearbox right. Then you got to hold everybody off.

The stakes werent as high Sunday as they were in November when a berth in the championship finale was on the line, but for a driver and team in the midst of a three-year-plus dry spell, what was before them carried considerable importance.

Kyle Larson had been second before the caution and after pitting he would be fourth, the highest-placed among drivers on fresh tires, and in the preferred outside groove. He would likely be Newmans biggest threat provided he didnt get bogged down in traffic.

That didnt occur.

When the green flag waved Newman did his part and edged ahead, but as anticipated Larson got a terrific restart and was closing. However, instead of exercising patience, Larson attempted to swing low and to the inside of Newman. Unbeknownst to Larson, Ricky Stenhouse Jr. was there and Larson cut across his nose just as Kenseth had done to Bowman last fall.

Hindsight is always 20/20, but I should have went a lane up in (Turns) 1 and 2, Larson said. I should have known to just stay close to Newman. That's what I wish I would have done.

To his credit, Larson didnt crash. The bobble, though, allowed Newman to build enough of a gap that there wasnt enough time to chase him down and make a pass.

For the first time since July 28, 2013, Newman was on his way to victory lane. And for the first time since Nov. 3, 2013, a RCR driver had picked up a Cup Series checkered flag.

Going a long time without winning, you have confidence in your mind that you can do it, Newman said. You just got to stay humble. This sport, you walk away from it, there's one guy that wins, 39 losers. You have to be humble walking into it that you're probably not going to win that day. Odds are against you.

On the surface it may appear as if Newman stole a race he had no business winning. That couldnt be farther from the truth.

It took a combination of sage strategy by Lambert and Newmans veteran savviness to make it happen. The other six teams ahead of Newman couldve employed the same strategy as Lambert and not pitted under the final caution. Yet, it was Lambert who made the correct call. And on worn tires, it wouldve really been easy for Newman to stumble on the restart.

Sunday may have been an upset, but dont think for a second that it wasnt earned.

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NASCAR Phoenix recap: The anatomy of Ryan Newman's upset win - SB Nation

PaleyFest 2017: Grey’s Anatomy Cast Talks Shonda Rhimes – Vulture – Vulture

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PaleyFest 2017: Grey's Anatomy Cast Talks Shonda Rhimes - Vulture - Vulture

McCain and Montenegro: The Anatomy of a Conspiracy Theory by … – Antiwar.com

Just in case you thought the conspiracy theory that Russia secretly controls the US government is exclusively an affliction affecting the Democratic party, Sen. John McCains recent performance on the floor of the US Senate should disabuse you of this optimistic notion. Responding to Sen. Rand Pauls blocking of a vote in favor of the accession of Montenegro to NATO, the failed former GOP presidential candidate let it all hang out:

I note the senator from Kentucky leaving the floor without justification or any rationale for the action he has just taken. That is really remarkable, that a senator blocking a treaty that is supported by the overwhelming number, perhaps 98 at least of his colleagues would come to the floor and object and walk away. The only conclusion you can draw when he walks away is he has no justification for his objection to having a small nation be part of NATO that is under assault from the Russians. So I repeat again, the senator from Kentucky is now working for Vladimir Putin.

Whats remarkable is that this kind of lunacy is tolerated in the US Senate: I recall that Sen. Elizabeth Warren was rebuked and silenced by Senate majority leader Mitch McConnell because she read a letter from Coretta Scott King that called into question the motives of Jeff Sessions, then a Senator and a candidate for the office of Attorney General. Surely McCains outburst was an even more egregious violation of the rules than Warrens, and yet McCain was allowed to proceed uninterrupted. Perhaps this is an example of warmongers privilege.

In a later interview, Sen. Paul sought to explain McCains behavior as an indication of the Senator from Arizonas advanced age: perhaps, he suggested, McCain is past his prime, and, by the way, this is a good argument for term limits. Well, yes, but in the current political atmosphere where Vladimir Putin has been elevated to the status of a virtually omnipotent force who has the power to change election results and infiltrate the highest reaches of Western governments its no crazier than anything else were hearing out of Washington these days.

Be that as it may, ordinary Americans may have a few questions about this bizarre incident, starting with: What the heck is Montenegro?

A tiny republic in the middle of the Balkans, Montenegro has a population equal to that of Albuquerque, New Mexico, and a military force of around 2,000 soldiers and sailors. Up until the break up of Yugoslavia, it was never a unified independent country (except for a few years early in the twentieth century). Today, it is even less unified, beset as it is with rival factions that routinely battle it out in the streets. Its former President (and, alternately, Prime Minister) Milo Djukanovic, is a former top Communist official who came to power in 1997 in an election marred by allegations of fraud and violent protests, and is known as Mr. Ten Percent on account of his reputation for corruption. Although retired (this is, I believe, his third retirement) he is still the real nexus of power in the country.

Formerly a bastion of Serbian nationalism, Montenegro has undergone demographic changes since the end of the Yugoslav era, with a large incursion of Albanians who have initiated a campaign to create a Greater Albania by merging the southern portion of the country with Albania proper. Aside from that, however, there is the question of whether Montenegro will join NATO and the European Union, a project dear to the heart of Djukanovic, and opposed by the former Serbian majority which still remembers how the country was bombed under NATOs rubric during the Kosovo war.

The recent elections, billed as a referendum on NATO membership, yielded ambiguous results for Djukanovics party: the hope was that Djukanovics Democratic Party of Socialists (DPS), the successor to the old Communist Party, would win an outright majority, thus enabling the pro-NATO forces to push NATO membership through parliament without having to resort to a referendum. The DPS ended up winning 41 percent of the vote, not enough to form a government, although an alliance with smaller parties not all of them pro-NATO gave Djukanovic a parliamentary majority. The opposition parties are now pushing for a popular vote on entering NATO, and recent polls indicate that voters are split almost exactly down the middle on the issue.

That doesnt deter Djukanovic, who, with the help of the Western media, has managed to replicate the anti-Russian hysteria we are seeing infect our own politics. According to Djukanovic, a Russian plot to attack the parliament, kill members of the ruling party, and take over the country was narrowly averted when a number of plotters were arrested. The New York Times describes these sinister plotters as follows:

Mr. Djukanovic and his officials initially provided no evidence to support their allegation of a foiled coup attempt on Oct. 16, the day of national elections. They said only that 20 Serbs some of whom turned out to be elderly and in ill health had been detained just hours before they were to launch the alleged putsch. Nonetheless, Mr. Djukanovic insisted it is more than obvious that unnamed Russian structures were working with pro-Moscow politicians to derail the countrys efforts to join NATO.

After months of searching, the alleged weapons cache that was to be used in the coup attempt has yet to turn up. But, hey, who needs weapons when youre part of the vast Putinite Conspiracy? Oh, those Russians stealing elections from Michigan to Montenegro! Is there anything they cant do? The alleged leader of the plot has been granted a plea deal, and is now spinning a tale of intrigue so murky that light cannot penetrate its depths. One version has it that Russian special forces disguised as a Cossack folk band arrived on the scene to recruit those plotting to off Djukanovic. Those are some very special forces indeed. Oddly, the alleged plotters have all been released, including the supposed ringleader. Meanwhile, leaders of the anti-NATO opposition are being arrested for ties to the plot.

This what Sen. McCain was talking about when he claimed that Montenegro is under assault from the Russians. Its the Montenegrin version of the same line of baloney hes been pushing here in the US: that the Russians stole the 2016 presidential election, and are subverting American democracy.

Sen. Paul was right to block approval of Montenegros accession to NATO: that country is the perfect backdrop for an international incident that would drag us into a conflict with Russia. In accusing Paul of working for Vladimir Putin, McCain is limning the tactics of Djukanovic, who is busy framing up and arresting his political opponents on similarly phony charges.

The alleged Russian agent Mike Flynn, forced to resign as National Security Advisor because of his nonexistent ties to Moscow, reportedly recommended that the Trump administration approve Montenegros bid to join NATO. I guess he didnt get his directive from Putin in a timely manner. On the other hand, the Montenegrin opposition is petitioning Trump advisor Steve Bannon to urge the President to veto it.

Montenegros accession to NATO would plant yet another tripwire that could easily lead directly to a collision with Russia. At the very least it would cause substantial internal turmoil in the country, perhaps ending in an all-out civil war such as happened in Ukraine.

President Trump was right when he said during the campaign that NATO is obsolete. It is also dangerous in that it pledges us to go to war in defense of member nations. With Turkey, a NATO member, moving rapidly into Syria, and now face-to-face with Russian and Syrian soldiers, and with British troops now entering Estonia, where a make-believe Russian threat is supposedly being thwarted, our membership in NATO could very well drag us into a conflict on two fronts.

How is this putting America first?

NOTES IN THE MARGIN

You can check out my Twitter feed by going here. But please note that my tweets are sometimes deliberately provocative, often made in jest, and largely consist of me thinking out loud.

Ive written a couple of books, which you might want to peruse. Here is the link for buying the second edition of my 1993 book, Reclaiming the American Right: The Lost Legacy of the Conservative Movement, with an Introduction by Prof. George W. Carey, a Foreword by Patrick J. Buchanan, and critical essays by Scott Richert and David Gordon (ISI Books, 2008).

You can buy An Enemy of the State: The Life of Murray N. Rothbard (Prometheus Books, 2000), my biography of the great libertarian thinker, here.

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McCain and Montenegro: The Anatomy of a Conspiracy Theory by ... - Antiwar.com

Grey’s Anatomy: Caterina Scorsone Is Just as Frustrated with Amelia as Fans Are – TV Guide (blog)

Now Playing Grey's Anatomy: Caterina Scorsone Wants Fans to Keep Rooting for Amelia and Owen

For Grey's Anatomy fans who have been frustrated by Amelia (Caterina Scorsone) essentially going into hiding after suddenly leaving her husband Owen (Kevin McKidd) with a Dear John letter earlier this season, you're not alone.

"I feel you. I feel you," Scorsone empathized, when TVGuide.com caught up with her at the PaleyFest Grey's Anatomy panel this past weekend. "There are so many layers to her, and I think Owen is maybe not the easiest person to talk to all the time."

The tension between Amelia and Owen will come to a rather unpleasant head on this week's episode, when they're forced to work together on a medical case. But the nail might not be in the coffin of their relationship just yet, and Scorsone is hoping that fans haven't given up on the relationship -- because she hasn't.

Grey's Anatomy: Justin Chambers weighs in on the Jo vs. Meredith debate

"I'm rooting for you guys to keep rooting for us," she tells us.

Check out the interview to see what else Scorsone says we can expect from Amelia and Owen this season.

Grey's Anatomy airs Thursdays at 8/7c on ABC.

(Reporting by Megan Vick)

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Grey's Anatomy: Caterina Scorsone Is Just as Frustrated with Amelia as Fans Are - TV Guide (blog)

Anatomy Of A Decision, Part 1: The C-Suite – Benzinga

Professional networking leader GLG has produced a new series of videos focused on decision making in the business world. As part of the series, GLG has interviewed a number of business leaders to ask about what considerations go into making important decisions.

In the first installment, GLG speaks with former Pfizer Inc. (NYSE: PFE) CEO Jeff Kindler.

Kindler said a key ingredient in his meteoric rise was an open mind.

I started saying I should be open to whatever comes along, Kindler said. And that led me down all kinds of different paths I never would have predicted.

Kindler joined Pfizer as the pharma giants general council, but he admits that he had always had ambitions to be CEO. Once he assumed the role, he was presented with an opportunity to work with former President Barack Obama on the Affordable Care Act (ACA).

Kindler said many of the provision being discussed at the time were politically polarizing but would have been universally bad for the pharmaceutical industry. Rather than fight the change, Kindler and a handful of other pharma CEOs decided to take a more constructive approach.

We formed a small group of five of us who were CEOs of different companies in pharmaceuticals with different interests and a different focus, and we decided that within the right boundaries, if we could achieve acceptable policy solutions, we would support the bill, Kindler recalled.

To this day, there are people who dont like what we did, even within the pharmaceutical industry. But my view is I got attacked by both the Wall Street Journal and the New York Times editorial page, and I think when that happens you know youre in the sweet spot.

Kindler sees his participation in the process as a valuable lesson in the power of compromise. While the pharmaceutical industry made a number of financial sacrifices as part of the process, he and his colleagues were also able help shape the bill to maximize potential industry benefits.

Kindler said the success of Obamacare to this day depends on perspective. In terms of increasing health insurance coverage, the program was a complete success. In terms of fixing the underlying problems of rising healthcare costs, Kindler believes Obamacare hasnt delivered.

He closed the interview by discussing one key regret he has about his time as CEO.

I think I fell prey to something thats in human nature, which is I didnt block enough time for personal development. I think a lot of [people] that are Type A personalities end up in big jobs, and theyre so focused on both the fact that they have achieved that and the things that they need to do on it that they just dont pay attention enough to the things that are of long-term importance.

Kindler said time management, prioritization and mentorship were three of the biggest challenges of such an important professional role.

Related Link:

6 Outsider CEO Hires That Flopped

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Anatomy Of A Decision, Part 1: The C-Suite - Benzinga

‘Grey’s Anatomy’ star joins rally for LGBTQ equality at Texas Capitol – KEYE TV

Former "Grey's Anatomy" star Sara Ramirez spoke out for LGBTQ equality in Texas at the Capitol on Monday. (Photo: CBS Austin)

Actress Sara Ramirez, star of ABC's "Grey's Anatomy," joined groups rallying for pro-LGBT equality at the Texas Capitol on Monday.

Ramirez was joined by members of the Texas LGBTQ and faith communities, along with representatives from the ACLU of Texas, Equality Texas, Human Rights Campaign, Texas Freedom Network, and Transgender Education Network of Texas.

In a speech, Ramirez took aim SB 6, Texas' so-called "bathroom bill," calling it "a solution in search of a problem."

Demonstrators gathered to advocate for policies that would "improve the lives of LGBTQ Texans and to speak out against legislative proposals that would amount to state-sanctioned discrimination."

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'Grey's Anatomy' star joins rally for LGBTQ equality at Texas Capitol - KEYE TV

‘Grey’s Anatomy’s Jesse Williams & Sarah Drew on That Japril … – Entertainment Tonight

There might be hope for Jackson Avery (Jesse Williams) and April Kepner (Sarah Drew) after all!

Last week's episode of Grey's Anatomy saw the divorced pair open the door for a rekindled romance with a sexy hookup while in Montana on a case -- where they also met Jackson's estranged father (Eric Roberts). While the couple's future is still uncertain, Drew assured fans at PaleyFest on Sunday that Japril will always be together -- whether romantically or otherwise.

RELATED: 'Grey's Anatomy': Jackson Meets His Father and Reunites With April -- Are They Back Together?

"I think the main takeaway from that experience in Montana is that these two people... there's so much love there, there's so much respect there. They know each other so well," Drew said during the Grey's Anatomy panel. "Whether it continues and moves towards romance or stays platonic, we know for sure that these two are going to be okay, and that they're always going to depend on one another, and they will always be one another's person."

"At the end of the day, who knows [what will happen]?" she added.

Williams also commented on the pair's connection, calling April Jackson's "best friend."

"He has a great support system and an absolute failure in the same experience," he shared of the tense scene when Jackson comes face-to-face with his father. "He's doing it with the full support of his person, his best friend, April Kepner."

EXCLUSIVE: Sarah Drew on Juggling Greys Anatomy With Motherhood, Her TV Twins & Future of 'Japril'

"I was excited [for the scene]. It's been a big cloud over the character for his entire life, and my entire career playing him," Williams confessed. "It's been like, a big gaping hole, so being able to fill that in with a human being, with a person you can make eye contact with and ask all these questions... was a very exciting process."

"I really prepared myself by making sure I went over and understood my timeline, and what this character has been through, but also I was just really laid the table to be able to listen and be honest in the moment," he added.

Williams and Drew shot the episode on location in Montana, with Kevin McKidd (Owen Hunt) directing.

"We went off with Kevin to shoot episode 16 while all the rest of these guys were shooting episode 10 or 11, so we were shooting with the Scandal crew. We were working with a completely different crew, in a completely different set, on location. We were in the mountains," Drew revealed. "It really did feel like we were shooting a movie. It was really neat to get the chance to kind of get out of the hospital and follow just one specific story all the way through to the end, because we got the opportunity to really take time to listen."

"So much happened in the silence in that episode, which we just don't have the luxury for when we're servicing so many different storylines," she said. "So it was really amazing."

Photo: Getty Images

RELATED: Jesse Williams Slams Hollywood Whitewashing: 'The More Diverse a Movie Is, the More Money It Makes'

"I was so proud of Jesse and Sarah, and everyone... the work that we did," McKidd offered. "When I read that script, I wanted it to feel like an independent movie -- a really high end, quality independent movie. That was my approach."

"I really encouraged the actors to just breathe," he added, "and I think it turned into something beautiful."

While Jackson and his father hashed it out on Thursday's episode, there's clearly much more to the pair's story -- which Williams said he "would love" to explore.

"I really hope so, not just selfishly, for being able to work with such an incredibly talented actor [in Roberts]," he said. "I would love to. I think there's a lot left to do there."

RELATED: 'Grey's Anatomy,' 'Scandal' Picked Up for New Seasons

"We've planted a lot of seeds this season -- and that's one of them -- that resonate in a lot of ways," added Debbie Allen, who executive produces the series in addition to starring as Jackson's mother, Catherine Avery. "But there's more coming."

As for Williams and Drew's relationship in real life, the 35-year-old actor said it's "much more stable" -- though Ellen Pompeo and Justin Chambers arguably had the most chemistry on stage, as Chambers sweetly gave up his coat for his shivering co-star.

"We don't fight, and it's really helpful. I think that generally, it's a really lighthearted set. We crack a lot of jokes and have a lot of fun and try to save the drama for what's on screen," Williams admitted. "We're carrying that with us for weeks at a time to deliver, to serve it up to you, so it's a lot of heavy weight, a lot of drama, and drama that we're trying to figure out how to articulate for you. So we try to keep it light."

EXCLUSIVE: 'Grey's Anatomy' Stars Jesse Williams and Sarah Drew Say Jackson and April Will Find 'Happiness'

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'Grey's Anatomy's Jesse Williams & Sarah Drew on That Japril ... - Entertainment Tonight

Where the Dead ‘Grey’s Anatomy’ Docs Would Be Now If They Were Alive – Wetpaint

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Where the Dead 'Grey's Anatomy' Docs Would Be Now If They Were Alive - Wetpaint