Cancer Genetics and Therapix Biosciences Get Financial Boost – Yahoo Finance

NEW YORK, NY / ACCESSWIRE / March 24, 2017 / The companies' saw their stocks rise on Thursday based on the recent news that both will have a relatively stable financials to operate from. News of Therapix IPO was more successful than projected, while Cancer Genetics gave investors several reasons to cheer. Investors and owners in these companies may expect a better 2017. Therapix is conducting research on the use of cannabinoids as an alternative form of treatment for specific diseases and disorders.

RDI Initiates Coverage:

Cancer Genetics Inc. https://ub.rdinvesting.com/news/?ticker=CGIX

Therapix Biosciences Ltd. https://ub.rdinvesting.com/news/?ticker=TRPX

Cancer Genetics climbed up $0.45 per share on Thursday, to close at $3.35. In a press release, the company revealed its 4th quarter earnings and full year earnings for 2016. Highlights from the report are that its 2016 revenues were up a full 50% from 2015, rising by $9 million, from $18 million to $27 million. Fourth quarter revenues were not as spectacular, but great, rising by more than 30% to $7.2 million. One of the reasons for its consistent growth is its business relationship with 9 of the top 10 pharmaceutical and biotech companies around the world. These relationships offer better opportunities for future growth. The company had $9.5 million of cash and cash equivalents available on its books as on December31st, 2016, as compared to $19.5 million of the same reported at the end of year 2015 and it has reported a loss of $15.8 million or $1.00 per share for the year 2016. Cancer Genetics has raised $12 million through debt financing and additional $1 million through non-dilutive capital in the current quarter.

Access RDI's Cancer Genetics Research Report at: https://ub.rdinvesting.com/news/?ticker=CGIX

The company announced its IPO on Thursday, with the stock closing at $10.13 a share, up $1.15. Therapix Biosciences is a company that specializes in developing clinical-stage pharmaceuticals that are cannabinoid-based. The original IPO was for 2,000,000 American Depository Shares (ADS), with each ADS consisting of 40 ordinary shares of the company. The opening price was $6.00 per share. Projections are that the gross proceeds of the initial offering will be $12 million, before deduction of underwriting discounts, commissions and general offering expenses. The money raised will be used to advance the development of its two leading drug candidates, THX-TS01 which is targeted treat Tourette Syndrome, and THX-ULD01 which is targeted address the high value and underserved market of mild cognitive impairments. Both candidates are being prepared for FDA Phase 2 testing.

Access RDI's Therapix Biosciences Research Report at: https://ub.rdinvesting.com/news/?ticker=TRPX

Our Actionable Research on Cancer Genetics Inc. (NASDAQ: CGIX) and Therapix Biosciences Ltd. (NASDAQ: TRPX) can be downloaded free of charge at Research Driven Investing.

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Cancer Genetics and Therapix Biosciences Get Financial Boost - Yahoo Finance

Scientists Think They’ve Traced the Very First Mutations in a Human Life – ScienceAlert

For the first time, scientists have caught a glimpse of the earliest genetic mutations in human development.

Using whole genome sequencing, they wound back time on cell samples from adults and revealed what took place in the genome when they were still microscopic embryos. It turns out, our first two cells contribute to our development in very different ways.

Mutations come in two forms:the hereditary ones we get from our parents, which can be found in virtually every cell of the body; and the acquired (or somatic) mutations that can occur at any stage of a person's life, including those very first days when the embryo is just starting to split into multiple cells.

Somatic mutations don't necessarily cause problems, but they can sometimeslead to cancerand other diseases. They also don't necessarily live in every cell (that's calledmosaicism).

We have a fairly murky understanding of the somatic mutations that happen during the earliest life stages, because we can't just watch that stuff happening in real time.

But now researchers have discovered a way to trace these mutations back to their first appearance.

"This is the first time that anyone has seen where mutations arise in the very early human development. It is like finding a needle in a haystack," says geneticist Young Seok Ju from the Wellcome Trust Sanger Institute in the UK and the Korea Advanced Institute of Science and Technology.

"There are just a handful of these mutations, compared with millions of inherited genetic variations, and finding them allowed us to track what happened during embryogenesis."

To find these mutations, the team analysed blood and tissue samples from 279 people with breast cancer.Using samples from cancer patients allowed them to test whether mutations were present in both normal blood and tissue, and in surgically removed tumour samples.

Since breast cancer tumours develop from a single cell, a somatic mutation would either be present in every tumour cell, or not at all, which gives a clue to its possible origins.

By tracking and comparing the spread of different mutations in these various tissue samples, the scientists verified a whopping 163 mutations that must have happened within the first few cell divisions of the persons' embryonic development.

This gave them a unique insight into how early embryonic cells interact.

And that's not all - a statistical analysis revealed that when a fertilised egg divides for the first time, those two cells actually contribute building material for the rest of the body at different proportions.

It appears that one of the first two cells that make us up gives rise to 70 percent of the body tissue, while the other one chips in for the rest.

"We determined the relative contribution of the first embryonic cells to the adult blood cell pool and found one dominant cell - that led to 70 percent of the blood cells - and one minor cell," says molecular biologist Inigo Martincorena from the Sanger Institute.

"This opens an unprecedented window into the earliest stages of human development."

That's exciting, because having that window will let us discover even more about how humans develop and acquire various mutations from the get-go.

Even though the vast majority of mutations are random and harmless, occasionally they can affect an important gene, causing a developmental disorder or a disease.

"Essentially, the mutations are archaeological traces of embryonic development left in our adult tissues, so if we can find and interpret them, we can understand human embryology better," says lead researcher Mike Stratton, director of the Wellcome Trust Sanger Institute.

The researchers hope their discovery is just the first of many steps that will help us gain a better understanding of what happens to humans in the earliest days, when we're all nothing more than just a clump of cells.

The research was published in Nature.

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Scientists Think They've Traced the Very First Mutations in a Human Life - ScienceAlert

Anatomy of a zipping up – Banners On The Parkway

Depending on who you ask, Xaviers win probability bottomed out at or slightly after the final media timeout. NumberFire puts the Musketeers down to their last 2.92% when Parker Jackson-Cartwright jarred the second of the two free throws he earned right before the break. KenPom doesnt label each play, but he had Xavier down to right around 3% when Kadeem Allen made a layup with 2:52 to play.

When Allens layup went through the strings, Xavier was down to its last breath in a shootout that had seen Arizona not be able to pull away despite averaging 1.29 points per possession in their 55 trips down the floor to that point. To get back on top before time ran out, Xavier would need to outscore Arizona by at least 8 in the remaining 2:52. With the tenor of the game to that point, scoring 8 was always going to be the easier part. Then the defense went to work.

Xavier was in a 2-3/1-1-3 here with JP and Q chasing all around the perimeter. That obviously left some gaps when the ball rotated quickly, and with 10 seconds left on the shot clock, Trier tried a long three that would have been a dagger. Instead it rimmed out, and JP dropped in from the wing to rake it out and go.

Back into the zone again. One of the few times I agreed with Chris Webbers analysis of the game was right here. Ten seconds into the possession, Trier dribbled into a 17-footer from the right elbow area for reasons best known only to himself. It was a hard brick, and a the ball caught a couple of hands before going out of bounds to Xavier.

Things really started to tighten up here for Arizona. The freedom with which they had been playing for most of the game was all but gone as it became clear momentum was on Xaviers side. After a lot of dribbling around, Trier got himself caught in a blind alley on the left side of the lane. Trier gave up the ball - which was smart - but he did so to Tre, which was of debatable strategic value to Arizona.

Maybe my favorite possession of the game. With the season in the balance, Xavier was back in a man look and Arizona tried to iso Ristic on the block against Tyrique Jones. Ristic banged hard twice against Jones to drive him under the bucket; he gained exactly no ground. Stuck ten feet out along the right baseline, he turned and tried a half hook shot from a really narrow angle. It never really had a chance. Twenty hands battled for the rebound, but a monitor review showed that the last one it touched belonged to a Wildcat.

A break here to stop talking about defense for a minute. While the refs looked at the monitor, Coach Dale scanned the Hickory High huddle and decided to run Jimmy Chitwood off of a screen as a decoy Coach Mack called Corner Rip High-Low Counter. This wasnt a one-off play that Mack drew up in the huddle. It wasnt - as Chris Webber suggested on the telecast - just a case of Sean OMara happening to seal his man after Xavier called Trevon Bluietts number. It was an action Xavier has run over and over in the Mack Era, one that any coach could find in some back issue of the newsletter that the Xavier basketball program produces. It was also the perfect call to put Xavier on top.

Back to the zipping up.

Two and a half minutes ago, Arizona had this thing done and dusted. Now they needed a clutch shot to tie the game up and give themselves a chance. They didnt get it. Allen got free in the paint for a shot that wasnt horrible, but he wasnt able to convert and Xavier continued its second half trend by not allowing the Wildcats a second look at the rim.

One possession for the whole thing. With Xavier in a 2-3, Parker Jackson-Cartwright set a screen on Quentin Goodin to try to free Trier at the top of the key. Goodin - the strongest guard on the Xavier roster - fought over the screen in time to close out hard on Trier. Arizonas leading scorer jabbed stepped, used a dribble to create space, and lifted from deep. Q challenged high and hard, but - like Remy Abell a year ago - pulled his hands back to avoid contact. This time it rimmed out, Mal grabbed the board, and Xavier celebrated.

I cant find exactly where, but earlier this year I questioned if the Zip Em Up era was over at Xavier. Myles Davis represented a strong link to that time, but hes gone. Instead of burying games in the second half, X was fading out of them. It was all going to seed there in February.

Then something flipped a switch. Im sure part of it was Malcom Bernard, part of it was Coach Mack, and part of it was just each guy deciding what he wanted to be. Whatever it was, it all came together last night. In the six biggest defensive possessions of the year, Xavier held a top 20 offense to 0-5/0-2/0-0 shooting, forced a turnover, and gave up zero offensive rebounds. It was man, it was zone, it was a total team effort. It was everything we needed it to be.

White sheets. Yellow tape. Closed case.

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Anatomy of a zipping up - Banners On The Parkway

‘Grey’s Anatomy,’ NCAA: Ratings leaders – Orlando Sentinel – Orlando Sentinel

Greys Anatomy on ABC was the most-watched series Thursday night, but the NCAA Mens Basketball Tournament put CBS on top for the night.

Greys averaged 7.8 million viewers, according to Nielsen ratings released Friday afternoon. The viewing levels fell off for the ABC dramas that followed: Scandal with 5.4 million and The Catch with 3.4 million.

CBS aired Oregons close win over Michigan (7.1 million viewers) and Kansas blowout victory over Purdue (6.6 million). Cables TBS aired the other Sweet 16 games Thursday. The games across CBS and TBS averaged 11.2 million viewers Thursday up 17 percent from last year. It was the third most-watched coverage for the day in 24 years.

NBCs standouts were Superstore (4.1 million) and Blacklist: Redemption (4 million). Foxs best was MasterChef Junior with 3.8 million.

The prime-time averages for the broadcast networks: CBS with 6.9 million, ABC with 5.6 million, NBC with 4 million, Fox with 2.9 million and The CW with 850,000 for Supernatural reruns. But CBS easily won the 18-to-49 age group with the NCAA.

In Orlando, the top telecast was Greys Anatomy with 139,489 viewers, according to Nielsen ratings supplied to the Sentinel. Other favorites were Fox News Tucker Carlson Tonight with 89,072, Scandal with 82,631, Fox News Hannity with 80,753 and Fox News The OReilly Factor with 75,486.

With the local 18-to-49 age group, Greys and Scandal were the favorites. They were followed by Bobs Burgers on Adult Swim, Telemundos El Chema and the Kansas-Purdue game.

hboedeker@orlandosentinel.com

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'Grey's Anatomy,' NCAA: Ratings leaders - Orlando Sentinel - Orlando Sentinel

The anatomy of family murder – the patterns and warning signs | The … – The Independent

Just one week ago, on the evening of Saturday 19 March, a generally quiet north London neighbourhood, Finsbury Park, was rocked by a terrible crime, when two toddlers were found with critical injuries. Aman, said to be the birth father, has been arrested and charged with murder and attempted murder. Three of the more restrained headlines in response to these attacks read, depending on which newspaper one read: Man arrested over murder of one-year-old boy as his twin sister fights for life after alleged hammer attack (Daily Mirror); Man arrested on suspicion of murder after mother heard screaming for help as one-year-old boy is killed and sister is fighting for life, (The Daily Telegraph); and Distraught mother ran into street screaming my kids, my kids after finding her son beaten to death with a hammer (MailOnline).

The case has been set for a plea hearing in June, with a provisional trial date in September. The arrested man has yet to enter a plea and we must not second-guess the facts in this tragic case. However, this was the third distressing instance of multiple family victimsnationally in just three weeks. And those only the ones known to any audience beyond the local newssheet.

Less than two weeks before the Finsbury Park incident, police in Stowmarket found 65-year old carpenter and decorator Richard Pitkin dead. Also dead in the extended family home that used to boast a tea room was Sarah Pitkin, 58. The Pitkins, by report, were well-liked and respected. Police were not looking for anyone else in connection with their inquiries.

White House Farm in Essex, scene of the Bambermurders. The court decided Jeremy had placed the gun in his dead sisters hands to make it look like murder-suicide (Rex)

Stowmarket is a fairly small Suffolk town. Wolverhampton, by contrast, is a city of 250,000 inhabitants. But, just three days after news of the Stowmarket tragedy, the people of Wolverhampton were nonetheless alarmed to read in their copies of the Birmingham Mail: Man killed sister and knifed mum before killing himself.Had citizens and neighbours in that part of the Black Country turned to The Sun, even less would have been left to their imaginations: Maniac knifeman stabbed his sister to death and injured his mum before turning blade on himself in bloodbath at flat.

***

So in cases where there is family annihilation, what is it and why and why does it happen?

One of the most infamous family annihilations evertook place in sprawling White House Farm, Essex, on 7 August 1985. Sheila Bamber, her parents Neville and June Bamber, and her sons Nicholas and Daniel, were all killed that fateful day. Worse, Sheilas brother Jeremy Bamber, then aged 24, apparently staged everyones murder as if Sheila herself were the culprit. Homicide/suicide, surely? Police who initially attended the scene ironically in response to a panicked-sounding telephone call from Jeremy seemed content to accept that interpretation.

For weeks lasting into months, that narrative amazingly stayed unchallenged; and it is fair to say the incarcerated Bamber still maintains his absolute innocence three decades after his belated conviction. Five years ago this spring, his lawyers failed in their most recent attempt to gain his acquittal, or at least his release, this time before the European Court of Human Rights.

Conventional instances of homicide/suicide where the perpetrator cannot go to jail because he it is statistically far more likely to be a he is already dead, either at the scene of horror or perhaps at some secluded beauty spot nearby tend to have 10 common features.

The historical cases show is that in murder-suicides, first, the killer is, as said, likely to be a man: where familial, a son, brother or father rather than daughter, sister or mother. Second, isolation is frequently a factor, if not the deciding factor: geographical isolation, psychological or psychiatric isolation, perceived isolation within the family bullying, deprivation, marginalisation, or isolated status, disgrace.

Newspapers offer lurid headlines on the act, but rarely shed light on motive

Third, often the perpetrator is consumed with hatred: sometimes hatred is fuelled by resentment. And, fourth, one influence persuading someone to attack his own family so viciously is frequently a grudge: expulsion from the home, threatened separation, refusal of money, not being mentioned in a will, unfair accusations, a partners alleged infidelity or even something as trivial as youre forever nagging.

Fifth, the instrument of death is more often than not extremely violent: gun, sword, knife or hammer are preferred over suffocation or gassing. However, in recent years, fire appears to have been used more, perhaps because perpetrators are more aware of the importance of destroying DNA evidence, and with the terrible bonus that it is the fire or the smoke or both doing the killing, not the instigator.

Sixth, typically escape routes are blocked, and a time chosen when the family are near-at-hand, sleeping or watching TV. Keys are hidden. Those who rush upstairs are pursued. And those who rush downstairs are trapped. Elaborate precautions are taken that a getaway car is not to hand except for the killers use. Also, that killer needs to be faster down the street were one of his intended victims to achieve temporary freedom.

Seventh, it is likely that there have been lesser preparatory and experimental attacks before the final showdown. For example, survivors of domestic violence typically endure between 20 and 200 assaults before sounding the alarm and calling on neighbours, trusted siblings, or the police. Perhaps the family car is in an inexplicable crash. Or prowlers, maybe suspected of mere rogue-trading or peeping Tom-ery, are been seen near the later site of execution.

In the 1977 Pottery Cottage murders, Billy Hughes (inset) butchered a family in Eastmoor, near Baslow in Derbyshire (Derby Telegraph)

Eighth, pleas for mercy are routinely and callously ignored. Ninth, the perpetrator usually neither expects nor tolerates retaliation. He likely relies on past romance or deep-seated trust placed in him as one of us to deter any last-minute fracas.

Womens aid, womens assertiveness, women survivors, and womens self-defence groups place emphasis on attempting realistic self-protection. Naturally it is a truism that fighting back is risky, statistically abortive, sometimes provocative prior to an even worse fate, or very occasionally peremptory: a false alarm. Nobody should expect doomed family members always to have a heavy chair or flower-pot to hand but advice is sensibly given that if you are going to die in any case, you might as well attempt some resistance. And there is rare forensic evidence that the escaping man, whether or not he later self-harms or takes his own life, bears scratches, bruises, cuts or organ-damage that must have been inflicted by one, more, or even all, his targets.

Finally and disturbingly, tenth, if the killer dies during or following his act of family annihilation, could well be set to be rather than blamed: Poor soul ; Must have borne terrible suffering in the Army, at work, as a child....; Moment of madness ; Wonderful dad ; Not round to put the record straight, whatever. And this (probably undeserved) taking into account of past misfortune has possibly been orchestrated by the killer long before the act. Maybe letters have been written, certificates displayed, thousands of pounds raised for charity, compensation successfully awarded... anything to perpetuate a story of awful injustice, noble self-abnegation, valid self-sacrifice.Because the killers unbelievable yet curiously tenable accomplishment is to write the first version of history.

History he has himself fulfilled. History he has himself shaped. Maybe history could supply us with detailed statistics for (a) homicide/suicides; and (b) whole- family killings not attributed to an integral, or past, members of those threatened families?No such fortune. Whereas homicides (murders) appear in one table of figures, Suicides (sometimes attempted suicides) appear in other lists. Even then, statistic-gathering is chaotic, partly due to coroners hesitant to issue suicide verdicts.

Do other countries perhaps keep better records? No. What we do know is that family annihilation is occasionally cultural; also imitative. South Africa is blighted with two kindred phenomena: isolated Boer and/or white men, on the margins, killing their entire families then themselves; alternatively, a son: not impossibly a black or mixed-race son, killing his parents, maybe his siblings as well, with appropriation of assets an attributed motive.

As for the US, comparisons with UK family-killings are ever more fraught with difficulty. Guns and harmful weapons far more available than in Britain, and spree-killings of all types are hard to separate out from targeted killings of a culprits relatives, say with one or two bystanders also killed or injured. Home invasions in the States are certainly frequent but as few as 100 people each year die as a direct consequence of burglary or attempted burglary within the broken-into home; compared with at least 18,000 US suicides labelled suicides each year.

The Laitner familly at Suzannes (centre) 1983 wedding in Sheffield. Basil (left) along with Richard and Avril (right) were murdered hours later

Is alcohol an important component, giving the instigator more courage? Or are perpetrators drug-dependent? The jury is still out over mitigation. Who knows whether a killer with little or no regard to his own safety, his own discovery, his own lifespan, would have been more restrained with more inhibitions. Harmful substances certainly dont seem to reduce instances of family annihilation or their intensity.

***

So where do my 10 common factors leading to family annihilation leave we who survive; we the relations and friends who are not subject to our own familys annihilation or someone elses; we who read about it from the comfort of our armchairs; we who are safe, secure, cherished and uplifted at home? A difficult quandary. Arguably, more difficult in the aftermath of family annihilation than in the wake of almost any other crime, any other catastrophe, even any other unforeseeable disaster.

Nor do the police, the courts, psychiatrists, or social workers those whose daily employment is to help those in distress, but not this degree of distress give the rest of an easy lead; give us reasons, perhaps in reply to that familiar plea: give us a clue! Society buries family annihilation (undertakers, literally) because the subject is too painful; it is seemingly too far beyond comprehension. Maybe falsely, family annihilation is considered a flash-in-a-pan; perhaps it is put down far too quickly to the mental illness of which it is so obviously a manifestation; and crucially there is rarely a survivor, less so an attendant survivor, to enlighten either the authorities or the public.

Police, press, parliament, the Church, social services, the NHS, everyone most likely to be listened to, can usefully move on to more pressing issues because there is there is nobody to prosecute, and/or nobody who can be subject of a child protection conference, and/or nobody who can be reassessed as a risk; or else the intentional killer who is an accidental or purposeful survivor makes a full confession. In which case there are only three available disposals: long-termimprisonment, enduring committalto hospital, or leeway enough, without intention, for the prisoner to finally take his own life (far more likely, statistically, if he lived through an initial attempt so to do).

Ironically, societys certainty thatits all over and done with militates against prevention, mitigation, avoidance, of family annihilation in the future. So onlookers and professionals alike are tempted to close the chapter, to let bygones be bygones. Instead, it is beholden on everyone to take account of warning signs: buildups of spite and resentment; previous domestic violence; acrimonious divorce and separation; bankruptcy; custody and access sessions denied or giving rise to concern; threats.

Because threats are not always empty. What everyone takes to be bragging, bad-mouthing, intimidation or hyperbole might actually be a signpost to future family annihilation. So statutory reviews must in future be held before the event, not after.

***

Which brings me to my own commitment to find out more concerning family annihilation. That prompt came from four instances a little too near where I lived for comfort.

2017 marks 40 years after escaped prisoner Billy Hughes, now deceased, took a family hostage at a cottage in Eastmoor, near Baslow in Derbyshire, butchering Grandma, Grandad, the couples son-in-law and their granddaughter. Only Mum survived the Pottery Cottage Murders, even she within seconds of her own shooting or knifing. And Eastmoor is just four miles up the road from where for more than three decades we made our home.

The Shropshire estate at which in 2008 a millionaire with business problems murdered his wife and daughter before shooting dead their dogs and horses, setting fire to the house, and finally killing himself (PA)

Six years later came the Dore Wedding Day Massacre. A talented pupil taught by my wife crouched in her bedroom, in an affluent suburb of Sheffield, towards the end of the family celebrations that crowned her elder sisters marriage ceremony just hours earlier, and listened, listened, as every single member of her cherished family to hand solicitor father, doctor mother, older brother faced arbitrary execution at the other side of her hasty barricade. Grim. With worse for this young woman still to come. And all at the hands of a robber not a relative.

Came the day 10 years after that: at the time a I was a local government officer charged with supervising three childrens access to their mother at a voluntary-funded contact centre. I was returning from the centre when I heard that, in a lay-by just a few miles down the same road I was driving along, a jealous father, also a centre user, had had set light to himself and his two sons by a woman he had acrimoniously split from within the exactly parked care he had used for access to the children. Three bodies discovered within. No lads able to survive their ordeal, survive their access, and see their mother again; nor chance that mother should encounter, look after, love, her boys again. Total immolation. Total elimination.

One final coincidence: from 2011 to 2014, when I needed my car in the evening, I chose to park it at the other end of the alley opposite where Id moved to. And one enchanting summer afternoon, the cul-de-sac was full of police cars, sentries, men in white suits. I had not consciously registered the house before. It was semi-detached, privately owned, on the outer edge of a large post-war municipal estate. In succeeding days, I soon learnt Stepdad had murdered the widowed shopkeeper he had recently married, then laid on the same bed and stabbed himself to death. All because she had told him she had had enough.

In the face of such terrible calumny, in the light of such unimaginable discoveries, most observers, most survivors, most people holding Twitter or Facebook accounts, most readers of newspapers, will remain baffled as to why anyone, anywhere, would want to take them (those the murderer has known or loved) all with me thus releasing them from agony. Is this really the freedom from oppression a crazed killer yearns for? Or is this too speedy an escape from lifes trials and tribulations; too convincing a hope of a Better World than that into which we were all born?

Purportedly, family annihilation, family extinction, is absolute love absolute hatred? expressed absolutely. And whatever the reasoning behind it, this is an act committed so suddenly, so ruthlessly, so wilfully, it permits no second thoughts. No opportunity for reverse. No retrieval.

1) Christopher, aged 50, shot dead his wife, 49, and daughter, 15, before gunning down their horses and dogs and then setting alight his 1.2m Shropshire home in 2008. The former mattress and pizza-box salesman had made himself into a millionaire, but his business interests collapsed, leaving him in 4m of debt. Some say he killed his family in a crazed attempt to protect them from poverty they were about to face. The killer was caught on CCTV on the night of the blaze walking his mansion's grounds carrying a bucket, a rifle and lighter fluid for setting the fire.

2) The bodies of a mother, 44, her son, 13, anddaughter, nine, were found in February 2011. The mothers husband was working abroad. Police broke into the familys detached house, in the Midlands, after they were contacted by a concerned relation. The children were found in their bedrooms with stab wounds to their neck and chest. Their mother, a devout Roman Catholic, was in the bathroom with multiple knife wounds to her arms. An inquest heard that the womans mother called police after she was unable to contact her daughter. Police investigated the tragedy as a suspected double homicide-suicide.

3) A report into the care of a North-east of England ex-soldier, who shot dead four members of his family in 2006, found failings in the mental health care he received. David, 41, killed his aunt and uncle, both 70, and their sons Davids cousins aged 41 and 44. He was sentenced to a minimum term of 15 years after admitting manslaughter. There was a lack of communication between agencies.

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The anatomy of family murder - the patterns and warning signs | The ... - The Independent

‘Grey’s Anatomy’ Season 13’s In-Flight Episode Already Looks Bad for Meredith – Moviefone

Poor Meredith Grey (Ellen Pompeo) has the worst luck with planes. You may have already heard that "Grey's Anatomy" Season 13 has an upcoming episode "set entirely on a commercial airliner as a crisis unfolds mid-flight." TVLine revealed a photo from that April 13 episode, "In the Air Tonight," directed by Chandra Wilson (Miranda Bailey).

As you can see below, Meredith and Nathan Riggs (Martin Henderson) are seated next to each other on the plane, and Mer already looks troubled:

TVLine didn't have any other details, so we don't know if the crisis is a problem with the plane -- like fans could handle another crash after the Season 8 finale took Lexie Grey -- or a crisis with one of the passengers, and Grey and Riggs have to step in to help.

For all we know, there could be other doctors on that flight with them, although it kinda looks like maybe they are getting away together. If so, their expressions don't suggest a romantic start. They both look a bit alarmed, no? Or wary, at least. Mer does not look comfortable. Are her eyes red, or are we just reading too much into it? The woman next to them doesn't seem to be bothered.

Meanwhile, Ellen Pompeo played down the idea of Mer-Riggs romance, warning Entertainment Weekly "Don't get too excited." She added, "Whether you're ready or not, you have to make the leap; I don't know if she's ready." Mer hasn't forgotten you, Derek!

"Grey's" has some intriguing episodes coming up, including Episode 18, "Be Still, My Soul," directed by Pompeo. That one is next, and it's meant to be very emotional. Then we have Episode 19, "What's Inside," which sounds troubling for Stephanie, at least professionally. This in-flight episode is Episode 20. At some point, Jo's husband is expected to show up to cause drama. The season finale will be Episode 24, and it's meant to be dark, dramatic, and intense.

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'Grey's Anatomy' Season 13's In-Flight Episode Already Looks Bad for Meredith - Moviefone

16th-century book ‘may offer clues’ to female anatomy knowledge lag – Times of Malta

A censored 16th-century anatomy book may provide evidence that taboos slowed the development of knowledge of the female genitals, researchers have said.

The 1559 edition of Thomas Geminis Compediosa Totius Anatomie Delineatio features a depiction of a semi-dissected female torso, and the books original owner has cut away a neat triangle of paper on which the vagina would have been drawn.

It will be displayed in an exhibition at St Johns College at the University of Cambridge, and curator Shelley Hughes said it may offer clues as to why knowledge of the female anatomy lagged behind that of the human body as a whole.

She said the books original owner was disturbed by its depiction of a semi-dissected female torso.

We know this because the offending part, a neat triangle of paper on which the vagina would have been drawn, has been carefully cut away.

Sin and female flesh were held in close association in 16th-century society

She continued: Sin and female flesh were held in close association in 16th-century society with naked women often portrayed as the servants of Satan.

Before the 16th century, many European academics believed that female genital organs were simply lesser versions of male organs, turned inside out.

This dated back to classical medical authorities such as Galen in the 2nd century, who had been prohibited by law in Ancient Rome from cutting up human corpses.

The 16th century was a time of medical revolution, with pioneering researchers such as Andreas Vesalius challenging accepted views on anatomy, with evidence gathered from human dissections and direct observation experiment.

But there was still a reluctance to take on some foundational beliefs in science.

The display shows how an evidence-based knowledge of the structure of the body emerged as superstitious and religious barriers weakened.

The exhibition, on display at St Johns College at the University of Cambridge, is called Under the Knife at St Johns: A Medical History of Disease and Dissection.

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16th-century book 'may offer clues' to female anatomy knowledge lag - Times of Malta

NeuroScience founder sentenced and fined for fraud | Local News … – Madison.com

The head of a western Wisconsin laboratory has been sentenced, fined and harshly admonished after being found guilty of conspiring to defraud the federal government.

Gottfried Kellermann, 76, of Osceola, was sentenced Thursday by U.S. District Judge James D. Peterson to a six-month period of home confinement, a $50,000 fine, and five years of probation for intentionally violating Clinical Laboratory Improvement Amendments regulations. Kellermans co-defendant, NeuroScience, was sentenced to a five-year probation period and a $140,000 fine for conspiring to defraud, according to the U.S. Department of Justice.

Kellermann is the founder and CEO of NeuroScience and its sister company Pharmasan Labs. In the sentencing, the court found that Kellermann was "fundamentally unrepentant" and that his allocution showed "he was a self-deluded charlatan" and that the public needed to be protected, according to a press release from the Justice Department.

According to the court, Pharmasan conducted neurotransmitter testing, and NeuroScience recommended nutritional supplements to Pharmasan patients based on the results of the testing. When Pharmasan's neurotransmitter testing did not produce consistent results for patients, Kellermann manipulated the results unbeknownst to federal regulators and patients. NeuroScience then recommended nutritional products to the patients identified as abnormal but the Justice Department said the optimal range was not valid and was "significantly narrower than the range required by federal regulators." Kellermann and his companies, who were convicted in October, hid the range and that fact it was not valid from federal regulators and from their patients.

In 2015, Pharmasan was ordered to pay the federal government $8.5 million to settle claims that it submitted false billing information to Medicare. Federal prosecutors said the settlement resolved allegations that Pharmasan and its billing company, NeuroScience, also violated Medicare rules on services referred by practitioners who weren't doctors.

Kellermann, according to the Amery Free Press, is a native of Germany who has lived in the U.S. since the 1970s. His companies have been based in Oceola, a village along the St. Croix River in Polk County, since 2002.

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NeuroScience founder sentenced and fined for fraud | Local News ... - Madison.com

How neuroscience can help global companies bridge the gap with Indian customers – Economic Times

Imagine visiting the new neighbourhood ice-cream parlour that offers a wide range of fresh flavours. To help the bewildered customer spoilt for choice, the attendant hands over a tiny bright pink spoon, an apparatus to wear and samples for tasting. Should it be the toasted coconut gelato or the carrot mango ice-cream? The tasting begins and when the lick clicks, the gadget quite literally lights up, somehow capturing the brains best response and helping the customer decide which flavour to buy.

This is an example of consumer neuroscience at work, the next level of science in action for consumers. Its an application that enables decision making by manifesting ones innermost, subconscious mind.

Where there are consumers trying to decide, there are advertisers trying to pitch in and this is a science that both sides can use.

Consumer neuroscience helps measure the impact of emotional advertising by assessing metrics like attention, emotional engagement and memory activation, global marketing research firm Nielsen said in a report.

From a product or service perspective, advertising is not the only beneficiary. The packaging of a product is a fertile area where neuroscience can help right from what deciding what fonts to use to placement of information. Even the design of stores and their aisles can be suitably configured and reconfigured using neuroscience metrics. However, not all agree that consumer neuroscience is the ultimate concept when it comes to the creative aspect of advertising.

I truly believe that nothing can replace our wisdom, our gut and our well-honed craft, said Sonal Dabral, chairman of DDB Mudra Group, known for incorporating romanticism in his ads. But neuro helps the clients and agencies land the message right by eliminating the negatives in the script.

Still, neuroscience may emerge as a promising tool to help global companies bridge the gap with their Indian customers. As global entities set foot in India in increasing numbers, shifting operations and bases to the country, a parallel shift in research structures is missing. So, while the consumer is in India, the designs come from the western world and often lack Indian perspective, creating a mismatch.

To be sure, though, machines, multi-coloured lights and graphs cannot be relied upon blindly to decide the saleability of a product.

Food and beverage giant PepsiCo that has been in talks with several marketing research agencies in the last one year for the optimum use of the technique, credits consumer neuroscience for giving taste a dimension and expression.

We were shown an ad of Kurkure that we had made, three times, and our responses were being tested using neuroscience. After the second round, we were told that the in that round, the ad had been shortened by 15 secs, and we did not even get to know! So, using neuroscience they shaved off portions of the ad that did not heighten our emotions and that is how it helped in the editing too, Gaurav Mehta, senior director for insights and marketing services at PepsiCo, India, said, adding that it removes biases from consumer responses.

Relying solely on electric signals in India, with its multi-cultural underpinnings, can be inadequate.

Consumer neuroscience can work as a tool for validation but not as a tool for creation. It has to be coupled with the cultural context, which the brand looks at associating with, said Alpana Parida, MD of DY Works, a Mumbai-based brand strategy and design firm. ITC had launched a black cigarette which had registered quite well on neuroscience but ultimately did not do well since it did not fit the cultural context of our country.

As of now, the complete neuroscience toolkit includes an electroencephalogram (EEG) to measure electrical brain activity, core biometric indicators such as heart rate and skin response, facial coding and eye tracking. While the EEG provides detailed, secondby-second diagnostics on the effectiveness of stimuli, biometrics measure the level of engagement and facial coding reveals the depth of expressed emotion, Nielsen said. This articulation, integrated with a combination of neuroscience tools, enhances predictability to almost 84%, it said.

India has a near-negligible presence of consumer neuroscience experts. Neuroscience itself has very little research expertise in the country, said Krishna Miyapuram, professor at the Centre for Cognitive Science, IIT Gandhinagar, who has done extensive research on the cognitive processes of learning and decision-making mechanisms in humans. EEG is not an expensive equipment and can be acquired by companies, but neuroscience comes with its own paraphernalia and to adopt it in its entirety, you need neuroscientists, analysts to mine data.

Though still nascent in India, consumer neuroscience is not a novel concept globally. A wave of consumer neuroscience emerged around 2011, when Nielsen acquired Neurofocus, then the global leader in neurological testing, for consumer research. Many startups came up and died down, but now globally, the situation has stabilised. In 2015, Nielsen acquired another consumer neuroscience research group, Innerscope, and went on to become worlds largest consumer neuroscience company.

This doesnt mean that marketers will shy away from making use of some elements of neuroscience. Vitasta, the Indian marketing partner of Swedish company Tobii, a provider of eye-tracking solutions and services, has a list of clients that buy these devices, which come at an entry-level price of Rs 15 lakh.

The company also sells wearable devices that integrate the EEG and eye-tracking functions and are sold to both scientific institutes and commercial entities, ranging from FMCG companies and automobile makers to sports research institutes. The price for such devices varies between Rs 15 lakh and Rs 60 lakh.

The wonders of neuroscience have yet to be judged. Consumer neuroscience lays stress on emotions and their impact on decision-making, which in turn can provide insights into aspects such as how people buy products and services, brand loyalty, market testing and advertising strategy.

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How neuroscience can help global companies bridge the gap with Indian customers - Economic Times

Architects look to neuroscience to create happier, less distracting offices – HR Dive

Dive Brief:

Geek Wire reports that office design has been based on buildings first and people second. Design that puts people first can create work environments that make employees more comfortable, creative, productive and generally happier.

It's not the first time researchers have recommended experimenting with color in the workplace. One London-based research firm studied the working habits of so-called "thinking" workers in order to determine the effects of workplace stimuli. Among their findings? Cool colors and LED lights can improve alertness, and scents like lavender and jasmine can produce a calming effect.

The trend toward open, wall-free workspaces doesnt accommodate the workstyles of all employees. Hacker Moon reported on an anonymous study of 1,000 high-performing employees, many of whom are problem-solvers. The results showed that these workers reject open workspacesand instead prefer private, calm spaces where they can concentrate.

Also, as Geek Wire reported, Edward O. Wilson, Harvard University biologist and researcher, said that people are naturally attracted to open spaces.But in nature, if a predator threatens, or if in the workplace a conference call is too loud, people will retreat to a smaller, safer or quieter space.

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Architects look to neuroscience to create happier, less distracting offices - HR Dive